## Sat Jan 4 12:50:59 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA298972/SRR2844616/SRR2844616_p_cluster_rep_seq.fasta --output PRJNA298972_SRR2844616 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_429435_1 1000565.METUNv1_01128 1.56e-88 270.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,2KU6M@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the radical SAM superfamily. PqqE family pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_14,Radical_SAM,SPASM k59_429435_2 159087.Daro_1701 3.58e-34 119.0 2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,2VVSC@28216|Betaproteobacteria,2KX6Q@206389|Rhodocyclales 206389|Rhodocyclales S Coenzyme PQQ synthesis protein D (PqqD) pqqD - - ko:K06138 - - - - ko00000 - - - PqqD k59_429435_3 1000565.METUNv1_01126 1.69e-170 476.0 COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2VI0X@28216|Betaproteobacteria,2KUDW@206389|Rhodocyclales 206389|Rhodocyclales H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_429435_4 1000565.METUNv1_01125 3.28e-204 566.0 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,2VJUF@28216|Betaproteobacteria,2KVU8@206389|Rhodocyclales 206389|Rhodocyclales S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_429435_5 1000565.METUNv1_01124 3.27e-133 384.0 COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,2WGZA@28216|Betaproteobacteria,2KWAH@206389|Rhodocyclales 206389|Rhodocyclales U Bacterial type II and III secretion system protein - - - - - - - - - - - - Secretin k59_143588_1 1000565.METUNv1_03337 2.72e-153 442.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2VII5@28216|Betaproteobacteria,2KUUT@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA,GATase_3 k59_322411_1 765912.Thimo_0485 1.33e-21 88.6 COG1846@1|root,COG1846@2|Bacteria,1N19E@1224|Proteobacteria,1S6YD@1236|Gammaproteobacteria,1WYIS@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K06075 - - - - ko00000,ko03000 - - - MarR,MarR_2 k59_214856_1 1000565.METUNv1_02816 2.39e-79 251.0 COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2VIIU@28216|Betaproteobacteria,2KUNF@206389|Rhodocyclales 206389|Rhodocyclales G beta (1-6) glucans synthase - - 3.2.1.58 ko:K01210 ko00500,map00500 - R00308,R03115 RC00467 ko00000,ko00001,ko01000 - - - - k59_214856_2 1000565.METUNv1_02815 3.67e-76 249.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VHGG@28216|Betaproteobacteria,2KUZQ@206389|Rhodocyclales 206389|Rhodocyclales M Family 2 glycosyl transferase - - - - - - - - - - - - Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2 k59_571697_1 1000565.METUNv1_02140 1.05e-46 155.0 COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,2KWXI@206389|Rhodocyclales 206389|Rhodocyclales M Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_571697_2 1123355.JHYO01000003_gene2810 4.95e-28 109.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2VEUJ@28211|Alphaproteobacteria,371GJ@31993|Methylocystaceae 28211|Alphaproteobacteria L 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_571697_3 1000565.METUNv1_02138 1.4e-70 213.0 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria,2KWJI@206389|Rhodocyclales 206389|Rhodocyclales H dihydroneopterin aldolase folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_179617_1 1000565.METUNv1_00585 1.26e-292 824.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_786247_1 305700.B447_11892 3.31e-71 240.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVC7@206389|Rhodocyclales 206389|Rhodocyclales T PAC sensor-containing diguanylate cyclase phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS,PAS_9 k59_250754_1 232721.Ajs_0064 1.93e-77 236.0 COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,2VNXE@28216|Betaproteobacteria,4ABZ9@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1072001_1 640081.Dsui_2161 4.02e-308 860.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,2KVIZ@206389|Rhodocyclales 206389|Rhodocyclales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_107807_1 640081.Dsui_1383 5.65e-110 337.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_750275_1 1120999.JONM01000016_gene228 4.71e-59 196.0 COG4254@1|root,COG4254@2|Bacteria,1MYBD@1224|Proteobacteria,2VSSC@28216|Betaproteobacteria 28216|Betaproteobacteria S Sporulation related domain - - - - - - - - - - - - FecR,SPOR k59_750275_2 1000565.METUNv1_02674 1.2e-20 87.0 2DQ3W@1|root,334M9@2|Bacteria,1NF29@1224|Proteobacteria,2VXAP@28216|Betaproteobacteria,2KZ8V@206389|Rhodocyclales 206389|Rhodocyclales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_607292_1 1112217.PPL19_17630 3.47e-26 107.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Belongs to the mannose-6-phosphate isomerase type 2 family algA - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_999_2 395965.Msil_3633 1.25e-38 134.0 COG2197@1|root,COG2197@2|Bacteria,1RCCE@1224|Proteobacteria,2U6U1@28211|Alphaproteobacteria,3NB1N@45404|Beijerinckiaceae 28211|Alphaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_999_3 1538295.JY96_18315 3.51e-25 97.1 2E0VA@1|root,32WCJ@2|Bacteria,1RI6W@1224|Proteobacteria,2VU6K@28216|Betaproteobacteria,1KMEG@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_643705_1 1000565.METUNv1_01202 2.38e-49 180.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_214863_1 1000565.METUNv1_00402 0.0 908.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KVU3@206389|Rhodocyclales 206389|Rhodocyclales C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_214863_2 1000565.METUNv1_00401 1.73e-06 48.5 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales 206389|Rhodocyclales CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_786249_1 380703.AHA_2188 2.13e-115 380.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1Y3V7@135624|Aeromonadales 135624|Aeromonadales T Hpt domain - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_678868_2 358220.C380_12820 4.15e-202 570.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,4AA9X@80864|Comamonadaceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF853) yjgR - - ko:K06915 - - - - ko00000 - - - DUF853 k59_429465_1 358220.C380_03020 5.77e-88 278.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,4AA8W@80864|Comamonadaceae 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1107297_1 1116472.MGMO_4c00120 2.71e-44 167.0 COG4625@1|root,COG4625@2|Bacteria 2|Bacteria T pathogenesis pmp12 - - - - - - - - - - - Beta_helix,Cadherin-like,ChlamPMP_M,DUF1565,He_PIG,LTD k59_928585_1 614083.AWQR01000014_gene2478 5.31e-44 159.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,4AAB4@80864|Comamonadaceae 28216|Betaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_571716_1 1000565.METUNv1_03671 1.99e-82 278.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_643733_1 76114.ebA5443 1.23e-21 93.2 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,2KUN8@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_643733_2 1502852.FG94_03791 4.89e-33 120.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,472RV@75682|Oxalobacteraceae 28216|Betaproteobacteria S haloacid dehalogenase-like hydrolase ppaX - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_36599_1 1000565.METUNv1_02467 1.52e-145 436.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,2KVPX@206389|Rhodocyclales 206389|Rhodocyclales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1000238_1 1000565.METUNv1_00834 1.11e-70 217.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,2KW8D@206389|Rhodocyclales 206389|Rhodocyclales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1000238_2 29581.BW37_04905 2.09e-17 82.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,473K8@75682|Oxalobacteraceae 28216|Betaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_964424_1 1000565.METUNv1_01635 2.24e-116 337.0 COG2755@1|root,COG2755@2|Bacteria,1RDVJ@1224|Proteobacteria,2VHK1@28216|Betaproteobacteria 28216|Betaproteobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_964424_2 1000565.METUNv1_00435 4.06e-106 311.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,2KW7N@206389|Rhodocyclales 206389|Rhodocyclales S Carboxylesterase estB - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_964424_4 1000565.METUNv1_00433 2.58e-30 112.0 COG3235@1|root,COG3235@2|Bacteria,1RDMZ@1224|Proteobacteria,2WFSM@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - - - - - - - - - - - k59_893210_1 1000565.METUNv1_02939 3.78e-43 155.0 COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,2WGGE@28216|Betaproteobacteria 28216|Betaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_536099_1 1198452.Jab_1c15300 1.18e-99 314.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,472EF@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1035995_1 6669.EFX65282 4.92e-05 50.8 COG5108@1|root,KOG1038@2759|Eukaryota,38EAY@33154|Opisthokonta,3B9IU@33208|Metazoa,3CT0T@33213|Bilateria,41W6X@6656|Arthropoda 33208|Metazoa KL DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates POLRMT GO:0000428,GO:0000959,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006351,GO:0006352,GO:0006390,GO:0006391,GO:0006725,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0032774,GO:0032991,GO:0034062,GO:0034245,GO:0034641,GO:0034645,GO:0034654,GO:0042645,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0061695,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0097747,GO:0098798,GO:0140053,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234 2.7.11.1,2.7.7.6 ko:K10908,ko:K16310 - - - - ko00000,ko01000,ko01001,ko03029 - - - RNA_pol,RPOL_N k59_357944_2 1000565.METUNv1_02405 4.33e-177 504.0 COG2114@1|root,COG2114@2|Bacteria,1QWGZ@1224|Proteobacteria,2WEJJ@28216|Betaproteobacteria,2KZV9@206389|Rhodocyclales 206389|Rhodocyclales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_500955_1 1000565.METUNv1_02204 4.36e-93 283.0 COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,2VHDP@28216|Betaproteobacteria,2KVUR@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the heat shock protein 70 family - - - ko:K04046 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_214886_1 1304883.KI912532_gene1629 2.48e-48 161.0 COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,2KW96@206389|Rhodocyclales 206389|Rhodocyclales S Phasin protein - - - - - - - - - - - - Phasin_2 k59_107842_1 1000565.METUNv1_00386 6.65e-148 421.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,2KVUM@206389|Rhodocyclales 206389|Rhodocyclales P phosphate transport system pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_107842_2 1000565.METUNv1_00387 2.42e-39 137.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,2KUH7@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_250794_1 1000565.METUNv1_00678 4.48e-99 295.0 COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,2VKZK@28216|Betaproteobacteria,2KUFY@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the glucose-6-phosphate 1-epimerase family - - 5.1.3.15 ko:K01792 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 - R02739 RC00563 ko00000,ko00001,ko01000 - - - Aldose_epim k59_250794_2 1000565.METUNv1_00679 1.75e-94 276.0 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,2VSTN@28216|Betaproteobacteria,2KWN8@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_179669_1 398578.Daci_0284 2.1e-07 51.6 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,4ABQJ@80864|Comamonadaceae 28216|Betaproteobacteria O Mg chelatase subunit ChlI comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_179669_2 987059.RBXJA2T_11196 1.37e-65 200.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1KKVB@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Belongs to the P(II) protein family glnK - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1036008_1 1036674.A28LD_1628 5.23e-104 310.0 COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,1S1E3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oxidoreductase wblB - 1.1.1.335 ko:K13020 ko00520,map00520 - R10140 RC00182 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_36617_1 1288494.EBAPG3_27780 1.63e-82 260.0 28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,2VI32@28216|Betaproteobacteria,372Y4@32003|Nitrosomonadales 28216|Betaproteobacteria S TIGRFAM TIGR03790 family protein - - - - - - - - - - - - - k59_36617_2 1444310.JANV01000194_gene2529 2.16e-17 80.5 COG0451@1|root,COG0451@2|Bacteria,1TQV2@1239|Firmicutes,4HBXU@91061|Bacilli,1ZDTQ@1386|Bacillus 91061|Bacilli GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_714889_1 395495.Lcho_4123 3.16e-199 586.0 COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_429519_1 1000565.METUNv1_01261 1.93e-80 241.0 COG1585@1|root,COG1585@2|Bacteria,1N4FG@1224|Proteobacteria,2VTGB@28216|Betaproteobacteria,2KWSR@206389|Rhodocyclales 206389|Rhodocyclales OU NfeD-like C-terminal, partner-binding - - - ko:K07340 - - - - ko00000 - - - NfeD k59_429519_2 1208583.COMX_01480 3.86e-11 63.2 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2JPF8@204441|Rhodospirillales 204441|Rhodospirillales O prohibitin homologues - - - - - - - - - - - - Band_7,Band_7_C k59_928600_1 887062.HGR_04308 4.17e-132 379.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,4AAN8@80864|Comamonadaceae 28216|Betaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_107854_1 1121033.AUCF01000007_gene5866 6.38e-104 308.0 COG0115@1|root,COG0115@2|Bacteria,1MX5D@1224|Proteobacteria,2TRVR@28211|Alphaproteobacteria,2JQHN@204441|Rhodospirillales 204441|Rhodospirillales EH Amino-transferase class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1072088_1 1000565.METUNv1_01169 9.4e-158 457.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales 206389|Rhodocyclales G BT1 family - - - - - - - - - - - - BT1 k59_250807_1 99598.Cal7507_0275 3.16e-59 195.0 COG0500@1|root,COG2226@2|Bacteria,1G1ZW@1117|Cyanobacteria,1HMF5@1161|Nostocales 1117|Cyanobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_31 k59_179694_1 748247.AZKH_3848 9.9e-79 242.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,2KU9T@206389|Rhodocyclales 206389|Rhodocyclales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_715776_1 1000565.METUNv1_02428 5.66e-104 312.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,2KURU@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_715776_2 1000565.METUNv1_02427 2.6e-136 388.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,2KUBS@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_1000942_1 365044.Pnap_3566 7.92e-25 105.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,4ABM7@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase phbC2 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_1000942_2 1179778.PMM47T1_23597 5.83e-17 80.5 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC mgtA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0099131,GO:0099132 3.6.3.2 ko:K01531,ko:K12955 - - - - ko00000,ko01000 3.A.3.24,3.A.3.4 - iSF_1195.SF4248 Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1107961_1 1000565.METUNv1_02088 1.1e-206 575.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,2KV6W@206389|Rhodocyclales 206389|Rhodocyclales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_323613_1 1120977.JHUX01000004_gene2318 2.52e-32 126.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,3NIYG@468|Moraxellaceae 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_144292_1 700598.Niako_6435 3.85e-64 220.0 COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes 976|Bacteroidetes L SNF2 family N-terminal domain - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_215579_1 717772.THIAE_07755 4.62e-06 54.7 COG0810@1|root,COG5373@1|root,COG0810@2|Bacteria,COG5373@2|Bacteria,1MZXC@1224|Proteobacteria,1S4GB@1236|Gammaproteobacteria,46166@72273|Thiotrichales 72273|Thiotrichales M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_430619_1 1000565.METUNv1_00375 1.1e-192 540.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_215582_1 1000565.METUNv1_03862 2.55e-121 353.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,2VS3H@28216|Betaproteobacteria,2KWFE@206389|Rhodocyclales 206389|Rhodocyclales S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1000948_1 1000565.METUNv1_01984 3.33e-49 168.0 COG3203@1|root,COG3203@2|Bacteria,1N1KC@1224|Proteobacteria,2VKGE@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM porin Gram-negative type - - - - - - - - - - - - Porin_4 k59_1000948_2 1000565.METUNv1_01985 1.46e-170 490.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VM62@28216|Betaproteobacteria,2KY65@206389|Rhodocyclales 206389|Rhodocyclales G PQQ-like domain - - - - - - - - - - - - PQQ k59_536779_1 1000565.METUNv1_03476 2.85e-165 471.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VHTW@28216|Betaproteobacteria,2KUCA@206389|Rhodocyclales 206389|Rhodocyclales EGP drug resistance transporter - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_667087_1 665942.HMPREF1022_00139 2.57e-58 200.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,42UU6@68525|delta/epsilon subdivisions,2X85I@28221|Deltaproteobacteria,2MCJ2@213115|Desulfovibrionales 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_976935_1 640081.Dsui_0900 7.08e-48 162.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,2KVN6@206389|Rhodocyclales 206389|Rhodocyclales EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_976935_2 1454004.AW11_01778 1.69e-09 58.2 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,1KPVQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1090814_1 118173.KB235914_gene2445 7.61e-82 253.0 COG4870@1|root,COG4870@2|Bacteria,1G85R@1117|Cyanobacteria,1H9NA@1150|Oscillatoriales 1117|Cyanobacteria O PFAM Papain family cysteine protease - - - - - - - - - - - - Peptidase_C1 k59_836441_1 1168034.FH5T_11515 2.78e-12 67.4 COG4591@1|root,COG4591@2|Bacteria,4NFWZ@976|Bacteroidetes,2FMHC@200643|Bacteroidia 976|Bacteroidetes M Efflux ABC transporter, permease protein lolE_1 - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_836441_2 714943.Mucpa_6106 1.72e-35 129.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1IPXJ@117747|Sphingobacteriia 976|Bacteroidetes S PFAM ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_523722_1 1298593.TOL_3066 4.07e-38 140.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T23Z@1236|Gammaproteobacteria,1XRJH@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF k59_976954_1 1123248.KB893315_gene3004 6.13e-35 130.0 COG1668@1|root,COG1668@2|Bacteria,4NFSZ@976|Bacteroidetes,1IR1T@117747|Sphingobacteriia 976|Bacteroidetes CP ABC-type Na efflux pump, permease component natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1051626_1 1121035.AUCH01000003_gene1301 7.16e-15 72.8 2AGQH@1|root,316Y7@2|Bacteria,1PY61@1224|Proteobacteria,2WDF3@28216|Betaproteobacteria,2KZBP@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1051626_2 1198452.Jab_2c16980 1.56e-31 125.0 COG1816@1|root,COG1816@2|Bacteria,1NHKA@1224|Proteobacteria,2VW34@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - - - - - - - - - - - - k59_801692_1 582744.Msip34_2824 7.49e-55 178.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,2KM9W@206350|Nitrosomonadales 206350|Nitrosomonadales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_801692_2 1387312.BAUS01000004_gene1495 2.14e-28 109.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,2KMP1@206350|Nitrosomonadales 206350|Nitrosomonadales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_836450_1 572477.Alvin_0458 1.18e-42 156.0 COG0715@1|root,COG2199@1|root,COG0715@2|Bacteria,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1SJP8@1236|Gammaproteobacteria,1X2T7@135613|Chromatiales 135613|Chromatiales PT NMT1/THI5 like - - - - - - - - - - - - GGDEF,NMT1 k59_523733_1 444875.E3SMD8_9CAUD 4.96e-53 171.0 4QD0J@10239|Viruses,4R0A5@35237|dsDNA viruses no RNA stage,4QSK9@28883|Caudovirales,4QNR4@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_667125_1 1000565.METUNv1_03768 1.97e-17 85.9 COG0367@1|root,COG0367@2|Bacteria,1R769@1224|Proteobacteria,2W1JM@28216|Betaproteobacteria 28216|Betaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_479616_1 999141.GME_15915 2.52e-86 283.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XHB4@135619|Oceanospirillales 135619|Oceanospirillales E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_871388_2 1215092.PA6_033_00110 3.18e-05 47.4 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,Hpt,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_1051654_2 1232410.KI421421_gene3788 1.36e-47 165.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria,43T0V@69541|Desulfuromonadales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_225662_1 1000565.METUNv1_02003 8.3e-153 441.0 COG3211@1|root,COG3211@2|Bacteria,1R690@1224|Proteobacteria,2VMQX@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,VPEP k59_121598_2 583355.Caka_2680 5.23e-20 89.7 COG1397@1|root,COG1397@2|Bacteria 2|Bacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_523766_1 1286631.X805_07650 1.08e-64 221.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,1KITV@119065|unclassified Burkholderiales 28216|Betaproteobacteria V TIGRFAM type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_801719_1 925409.KI911562_gene1678 6.83e-37 134.0 COG0489@1|root,COG0489@2|Bacteria,4NF5I@976|Bacteroidetes,1IQKF@117747|Sphingobacteriia 976|Bacteroidetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_479646_1 1000565.METUNv1_00647 1.19e-17 80.5 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,2KWHN@206389|Rhodocyclales 206389|Rhodocyclales O Tetratricopeptide repeat - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_479646_2 1000565.METUNv1_00646 1.82e-74 228.0 COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2VRAT@28216|Betaproteobacteria,2KWSB@206389|Rhodocyclales 206389|Rhodocyclales L G T U mismatch-specific DNA glycosylase mug - - - - - - - - - - - UDG k59_479647_1 517433.PanABDRAFT_4268 3.13e-18 77.0 COG1724@1|root,COG1724@2|Bacteria,1NEK5@1224|Proteobacteria,1T0QB@1236|Gammaproteobacteria 1236|Gammaproteobacteria N HicA toxin of bacterial toxin-antitoxin, - - - - - - - - - - - - HicA_toxin k59_479647_2 172667.Q7Y3V7_9CAUD 2.44e-23 93.6 4QDDU@10239|Viruses,4QTDD@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_523783_2 1123354.AUDR01000016_gene1339 3.35e-32 123.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,1KT1U@119069|Hydrogenophilales 119069|Hydrogenophilales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1051686_1 745411.B3C1_04160 2.8e-15 75.1 COG4989@1|root,COG4989@2|Bacteria,1MY3G@1224|Proteobacteria,1RRIC@1236|Gammaproteobacteria,1J5RM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Aldo/keto reductase family ydhF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Aldo_ket_red k59_762158_1 1000565.METUNv1_03642 1.2e-150 434.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KV3Q@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN1 - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_940533_1 1192124.LIG30_3384 6.14e-118 348.0 COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,1K1TU@119060|Burkholderiaceae 28216|Betaproteobacteria C electron transfer flavoprotein-ubiquinone oxidoreductase fixC - - ko:K00313 - - - - ko00000,ko01000 - - - DAO,FAD_binding_3,GIDA k59_121623_1 1000565.METUNv1_02444 3.25e-13 67.8 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,2VIX1@28216|Betaproteobacteria,2KV29@206389|Rhodocyclales 206389|Rhodocyclales S NIF3 (NGG1p interacting factor 3) - - - - - - - - - - - - NIF3 k59_907617_1 1165096.ARWF01000001_gene35 0.000267 48.9 COG1404@1|root,COG1404@2|Bacteria,1P2MM@1224|Proteobacteria,2W4F0@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - - k59_157891_1 1550091.JROE01000004_gene1466 1.54e-50 166.0 COG1136@1|root,COG1136@2|Bacteria,4NFDW@976|Bacteroidetes,1INQS@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_157891_2 1538644.KO02_16655 1.57e-22 97.8 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IQ8S@117747|Sphingobacteriia 976|Bacteroidetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_523816_1 1276756.AUEX01000011_gene1351 6.14e-98 298.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,4A9RZ@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_121632_2 388413.ALPR1_01975 1.41e-69 220.0 COG3828@1|root,COG3828@2|Bacteria,4NH8E@976|Bacteroidetes,47P81@768503|Cytophagia 976|Bacteroidetes S Trehalose utilisation - - - - - - - - - - - - ThuA k59_51173_2 1122621.ATZA01000020_gene4005 1.66e-31 118.0 2A1N9@1|root,30PWI@2|Bacteria,4NPMN@976|Bacteroidetes,1ISIP@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_977024_1 1458275.AZ34_06770 3.9e-115 349.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,4AAZS@80864|Comamonadaceae 28216|Betaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_202243_2 1201290.M902_2728 2.61e-21 91.7 COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,42TJ6@68525|delta/epsilon subdivisions,2MURK@213481|Bdellovibrionales,2WR3Z@28221|Deltaproteobacteria 213481|Bdellovibrionales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_667244_1 376686.Fjoh_0331 8.17e-86 259.0 COG1209@1|root,COG1209@2|Bacteria,4NE1U@976|Bacteroidetes,1HWWH@117743|Flavobacteriia,2NS8M@237|Flavobacterium 976|Bacteroidetes M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_667244_2 1349822.NSB1T_01245 5.12e-20 90.5 COG0475@1|root,COG0475@2|Bacteria,4NF11@976|Bacteroidetes,2FN0I@200643|Bacteroidia,22VV7@171551|Porphyromonadaceae 976|Bacteroidetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger,Usp k59_667246_1 395495.Lcho_1843 1.17e-121 362.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,1KIY7@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase alkK - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_302978_1 1538295.JY96_07970 1.41e-111 336.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VHE3@28216|Betaproteobacteria,1KNU6@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_157925_2 399795.CtesDRAFT_PD4530 1.31e-24 101.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,4AAHZ@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_762194_1 1479237.JMLY01000001_gene2275 6.74e-25 103.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,465MD@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1070 Sugar (pentulose and hexulose) kinases ygcE - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_762194_2 1120999.JONM01000004_gene3680 4.5e-26 105.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,2KPGR@206351|Neisseriales 206351|Neisseriales M Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_373950_1 640081.Dsui_0044 6.54e-106 311.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,2KUPT@206389|Rhodocyclales 206389|Rhodocyclales L exodeoxyribonuclease III - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_302990_1 1117379.BABA_05461 3.23e-36 137.0 COG0745@1|root,COG3852@1|root,COG0745@2|Bacteria,COG3852@2|Bacteria,1V2ZS@1239|Firmicutes,4HG6V@91061|Bacilli,1ZDT9@1386|Bacillus 91061|Bacilli T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_8,PAS_9,Response_reg,dCache_1 k59_302990_2 1380387.JADM01000010_gene3964 5.71e-10 59.3 COG1352@1|root,COG1352@2|Bacteria,1NQTI@1224|Proteobacteria,1RS9Z@1236|Gammaproteobacteria,1XMET@135619|Oceanospirillales 135619|Oceanospirillales NT chemotaxis - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_523898_1 1283287.KB822575_gene72 1.37e-86 271.0 COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4DNCJ@85009|Propionibacteriales 201174|Actinobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL2 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_617519_1 930169.B5T_01391 4.25e-72 239.0 COG1199@1|root,COG1199@2|Bacteria,1MVRJ@1224|Proteobacteria,1RQ7B@1236|Gammaproteobacteria,1XIJ7@135619|Oceanospirillales 135619|Oceanospirillales KL HELICc2 - - - - - - - - - - - - DEAD_2,Helicase_C_2 k59_871488_1 886293.Sinac_6931 1.69e-95 293.0 COG4102@1|root,COG4102@2|Bacteria,2IXNP@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1051803_1 443598.AUFA01000022_gene3249 5.56e-78 254.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,3JWB5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Coenzyme A transferase pct - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_157958_1 1121035.AUCH01000007_gene450 1.87e-100 314.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_728551_1 614083.AWQR01000030_gene2783 3.83e-54 189.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,4A9M7@80864|Comamonadaceae 28216|Betaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_345118_1 511062.GU3_06330 2e-05 47.4 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RQ6C@1236|Gammaproteobacteria,1Y4EJ@135624|Aeromonadales 135624|Aeromonadales P ATPases associated with a variety of cellular activities - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_407085_1 322710.Avin_44350 1.1e-91 279.0 COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,1RQ7M@1236|Gammaproteobacteria 1236|Gammaproteobacteria I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf k59_373998_1 1040989.AWZU01000073_gene3952 3.34e-63 217.0 COG0841@1|root,COG0841@2|Bacteria,1R93M@1224|Proteobacteria,2UP7I@28211|Alphaproteobacteria,3K354@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_266085_1 1223521.BBJX01000001_gene904 4.76e-50 174.0 COG1538@1|root,COG1538@2|Bacteria,1Q498@1224|Proteobacteria,2VJCB@28216|Betaproteobacteria,4ABRA@80864|Comamonadaceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - ko:K12538 - M00328 - - ko00000,ko00002,ko02000,ko02044 1.B.17.1 - - OEP k59_452946_1 399795.CtesDRAFT_PD4854 3.38e-32 120.0 COG0329@1|root,COG0329@2|Bacteria,1MUNF@1224|Proteobacteria,2VH4S@28216|Betaproteobacteria,4ABAP@80864|Comamonadaceae 28216|Betaproteobacteria EM Belongs to the DapA family - - 4.2.1.41 ko:K01707 ko00053,ko01100,map00053,map01100 - R02279 RC00678 ko00000,ko00001,ko01000 - - - DHDPS k59_452946_2 595537.Varpa_1901 5.57e-24 95.9 COG4319@1|root,COG4319@2|Bacteria,1NCJR@1224|Proteobacteria,2VURJ@28216|Betaproteobacteria,4AHU7@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 k59_1014812_1 159087.Daro_1934 7.72e-14 71.2 COG0784@1|root,COG3290@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1 k59_618657_2 1500894.JQNN01000001_gene4219 3.89e-52 172.0 2DQY9@1|root,339CR@2|Bacteria,1NR8Y@1224|Proteobacteria,2VSAP@28216|Betaproteobacteria,4738H@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_408259_1 261292.Nit79A3_0425 1.2e-28 115.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2WH7R@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC transporter transmembrane region - - - ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran k59_408259_2 1453503.AU05_06795 2.61e-08 53.5 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1YFVE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_204352_1 1123073.KB899241_gene2125 7.35e-39 138.0 COG4976@1|root,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,1S6MW@1236|Gammaproteobacteria,1X5JP@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,TPR_16,TPR_2,TPR_4,TPR_8 k59_204352_2 1197906.CAJQ02000027_gene1493 5.42e-35 129.0 COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2U07M@28211|Alphaproteobacteria,3JQSM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_729901_2 161934.XP_010676254.1 2.96e-40 152.0 COG2801@1|root,KOG0017@2759|Eukaryota,3894V@33090|Viridiplantae,3GY0Z@35493|Streptophyta 35493|Streptophyta T Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_2 k59_618664_1 338969.Rfer_2287 1.44e-106 322.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,4AAM6@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_584463_1 748247.AZKH_0348 9.36e-25 105.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2VNUX@28216|Betaproteobacteria 28216|Betaproteobacteria S NHL repeat - - - - - - - - - - - - NHL k59_226957_1 1415780.JPOG01000001_gene2385 7.56e-08 56.6 29W19@1|root,30HJP@2|Bacteria,1R60N@1224|Proteobacteria,1S21W@1236|Gammaproteobacteria,1X6BC@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_152063_2 272942.RCAP_rcc00956 1.03e-36 139.0 COG1403@1|root,COG1403@2|Bacteria,1N09C@1224|Proteobacteria,2VFAT@28211|Alphaproteobacteria 28211|Alphaproteobacteria V HNH endonuclease - - - - - - - - - - - - - k59_474078_1 1380394.JADL01000009_gene3291 2.02e-37 134.0 COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2JS96@204441|Rhodospirillales 204441|Rhodospirillales L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_260393_1 1000565.METUNv1_00292 2.5e-86 259.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2WG5G@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_116229_1 1123367.C666_08945 1.65e-63 196.0 2CEU4@1|root,31AME@2|Bacteria,1NWTY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1086805_1 614083.AWQR01000022_gene12 1.08e-11 63.5 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,4AB9M@80864|Comamonadaceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_1086805_2 1120977.JHUX01000003_gene1861 3.06e-06 54.7 2BIY0@1|root,32D69@2|Bacteria,1PKIK@1224|Proteobacteria,1SN9J@1236|Gammaproteobacteria,3NRCN@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_757720_1 1499967.BAYZ01000158_gene463 1.35e-35 134.0 COG0430@1|root,COG0430@2|Bacteria,2NP9K@2323|unclassified Bacteria 2|Bacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_686529_1 700598.Niako_0413 2.72e-10 58.9 COG1595@1|root,COG1595@2|Bacteria,4NNEM@976|Bacteroidetes,1IRWR@117747|Sphingobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_971923_1 1366050.N234_05845 2.33e-58 190.0 COG1177@1|root,COG1177@2|Bacteria,1N0SF@1224|Proteobacteria,2VP0F@28216|Betaproteobacteria,1K02K@119060|Burkholderiaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_474109_1 1000565.METUNv1_03423 1.33e-97 296.0 COG1538@1|root,COG1538@2|Bacteria,1R6S1@1224|Proteobacteria,2VMHP@28216|Betaproteobacteria,2KV9S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_1086842_1 1000565.METUNv1_03992 4.18e-237 695.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971,DUF748 k59_444344_2 382640.BT_2303 4.47e-15 75.5 28IQ7@1|root,2Z8PY@2|Bacteria,1QU3H@1224|Proteobacteria,2TVXV@28211|Alphaproteobacteria,48UQP@772|Bartonellaceae 28211|Alphaproteobacteria S Partly homologous to recombination protein bet of bacteriophage Lambda (P03698) bet - - - - - - - - - - - RecT k59_367953_1 857087.Metme_1446 5.35e-58 199.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1XESP@135618|Methylococcales 135618|Methylococcales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB k59_9588_1 1000565.METUNv1_00670 1.8e-128 369.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2VRA8@28216|Betaproteobacteria,2KW7S@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate ribA - 3.5.4.25 ko:K01497 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 k59_367962_1 296591.Bpro_2828 1.14e-125 389.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4ACP2@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtC - - ko:K03296,ko:K07788,ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_613442_1 1121035.AUCH01000002_gene1714 2.54e-114 347.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales 206389|Rhodocyclales CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_336522_1 365046.Rta_28240 5.5e-76 233.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,4A9ZT@80864|Comamonadaceae 28216|Betaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_336522_2 1198452.Jab_1c19570 8.8e-32 120.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,472KR@75682|Oxalobacteraceae 28216|Betaproteobacteria P Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_116283_1 640081.Dsui_1570 2.08e-88 273.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KUN4@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_116283_2 522306.CAP2UW1_4018 8.32e-50 159.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,1KQ4C@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes yggX - - - - - - - - - - - Iron_traffic k59_221238_2 472759.Nhal_1036 2.62e-24 107.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1WYP2@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_515298_1 338969.Rfer_0477 3.54e-94 293.0 COG0457@1|root,COG0745@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,1NNCT@1224|Proteobacteria,2VK0Z@28216|Betaproteobacteria,4ABC4@80864|Comamonadaceae 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_4,TPR_8 k59_579117_1 1235800.C819_01271 1.7e-31 117.0 COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,27NC2@186928|unclassified Lachnospiraceae 186801|Clostridia L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_196124_1 365044.Pnap_0858 1.36e-128 374.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,4AAR6@80864|Comamonadaceae 28216|Betaproteobacteria S VWA domain containing CoxE-like protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_446627_2 1121033.AUCF01000003_gene3442 1.73e-21 86.3 COG0425@1|root,COG0425@2|Bacteria 2|Bacteria O sulfur carrier activity - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_446627_3 414684.RC1_2608 3.49e-77 231.0 COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2JS61@204441|Rhodospirillales 204441|Rhodospirillales K ROS/MUCR transcriptional regulator protein - - - - - - - - - - - - ROS_MUCR k59_117603_1 1000565.METUNv1_01302 3.32e-120 367.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KV4M@206389|Rhodocyclales 206389|Rhodocyclales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_580165_3 557598.LHK_01539 2.09e-135 401.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,2VU8A@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_614410_1 85643.Tmz1t_1054 5.36e-55 181.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KW5G@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_446646_1 981336.F944_00139 3.57e-79 239.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,3NIFW@468|Moraxellaceae 1236|Gammaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_446646_2 981336.F944_00138 3.6e-07 49.3 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,3NN47@468|Moraxellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_1045818_1 1095769.CAHF01000011_gene2058 5.43e-80 255.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,473D2@75682|Oxalobacteraceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_724726_1 1144319.PMI16_04521 7.32e-27 109.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,4737T@75682|Oxalobacteraceae 28216|Betaproteobacteria E PFAM Aminotransferase class I and II aspB - - - - - - - - - - - Aminotran_1_2 k59_724726_2 1100720.ALKN01000048_gene2344 7.47e-33 118.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,4AEEQ@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM thioesterase superfamily protein ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_614417_1 380703.AHA_2902 5.68e-158 450.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria,1Y5C7@135624|Aeromonadales 135624|Aeromonadales M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_117621_1 338969.Rfer_3168 4.88e-19 85.5 COG0664@1|root,COG0664@2|Bacteria,1RATP@1224|Proteobacteria,2VQKD@28216|Betaproteobacteria,4ADQR@80864|Comamonadaceae 28216|Betaproteobacteria K regulatory protein Crp - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_517538_1 1000565.METUNv1_01238 8.1e-124 366.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,2KU7K@206389|Rhodocyclales 206389|Rhodocyclales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_11008_2 159087.Daro_0342 5.39e-67 204.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,2KWBI@206389|Rhodocyclales 206389|Rhodocyclales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_11008_4 1000565.METUNv1_02285 1.28e-147 425.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,2KVBF@206389|Rhodocyclales 206389|Rhodocyclales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_661026_1 614083.AWQR01000006_gene343 0.000265 41.6 COG1539@1|root,COG1539@2|Bacteria,1RD8Q@1224|Proteobacteria,2VR6E@28216|Betaproteobacteria,4ADXQ@80864|Comamonadaceae 28216|Betaproteobacteria H dihydroneopterin aldolase - - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_661026_2 1100721.ALKO01000020_gene882 6.61e-58 182.0 COG1539@1|root,COG1539@2|Bacteria,1MY5Q@1224|Proteobacteria,2VRBR@28216|Betaproteobacteria,4AEPZ@80864|Comamonadaceae 28216|Betaproteobacteria H Dihydroneopterin aldolase folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_661026_3 1100721.ALKO01000020_gene883 7.17e-46 154.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,4AB7N@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase SDR - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 ko:K00059,ko:K03793 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_517550_2 1000565.METUNv1_03876 1.88e-41 142.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,2KVAG@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases nnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_867333_1 1177154.Y5S_02347 1.76e-06 50.4 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1XHV3@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_867333_2 349106.PsycPRwf_0821 5.66e-40 137.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,3NK0S@468|Moraxellaceae 1236|Gammaproteobacteria J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_338767_1 1192034.CAP_3668 7.58e-34 128.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2YTZ3@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_338767_2 358220.C380_16600 1.71e-68 207.0 2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria,4AEEU@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_298557_1 1538295.JY96_02200 4.25e-100 301.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,1KJ42@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_797758_1 766499.C357_00754 1.39e-47 167.0 COG3950@1|root,COG3950@2|Bacteria,1NT0V@1224|Proteobacteria,2U4NZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S AAA ATPase domain - - - - - - - - - - - - AAA_15,AAA_21 k59_797758_2 766499.C357_00759 3.57e-24 100.0 COG0732@1|root,COG0732@2|Bacteria 2|Bacteria V type I restriction modification DNA specificity domain hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_580193_1 1005048.CFU_0796 7.71e-60 206.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,473N6@75682|Oxalobacteraceae 28216|Betaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_724766_1 1095769.CAHF01000014_gene2844 3.15e-72 232.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria,4728U@75682|Oxalobacteraceae 28216|Betaproteobacteria F Amidohydrolase family pyrX - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_47427_2 716928.AJQT01000109_gene1179 3.76e-58 190.0 COG0863@1|root,COG0863@2|Bacteria,1PCS4@1224|Proteobacteria,2VDM8@28211|Alphaproteobacteria,4BIRX@82115|Rhizobiaceae 28211|Alphaproteobacteria H DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_338802_1 757424.Hsero_3083 2.73e-108 330.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4733B@75682|Oxalobacteraceae 28216|Betaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_797772_1 522306.CAP2UW1_3298 3.4e-57 196.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KQDW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase arnT - - - - - - - - - - - PMT,PMT_2 k59_446723_2 232721.Ajs_2563 2.12e-15 74.3 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,4ABC7@80864|Comamonadaceae 28216|Betaproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_937474_1 358220.C380_23080 1.17e-91 285.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,4ABX9@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein dctS - 2.7.13.3 ko:K11711 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_196242_1 338969.Rfer_3431 2.28e-134 397.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,4AA3W@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_338821_1 614083.AWQR01000002_gene3008 1.91e-22 94.4 COG2199@1|root,COG2771@1|root,COG2771@2|Bacteria,COG3706@2|Bacteria,1QWNG@1224|Proteobacteria,2WH3C@28216|Betaproteobacteria,4AJW5@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_338821_2 595537.Varpa_4854 2.06e-29 120.0 COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria,4ACV5@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_82738_2 1000565.METUNv1_00998 2.42e-83 250.0 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2VII6@28216|Betaproteobacteria,2KWJ4@206389|Rhodocyclales 206389|Rhodocyclales I Coenzyme A transferase - - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_446782_1 391008.Smal_3814 4.06e-42 156.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,1X3WR@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the glycosyl hydrolase 31 family - - - - - - - - - - - - DUF4968,DUF5110,F5_F8_type_C,Glyco_hydro_31,NPCBM k59_614473_1 748247.AZKH_0326 3.25e-74 236.0 2CJJV@1|root,34AQW@2|Bacteria,1NZZY@1224|Proteobacteria,2W4R2@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_517663_1 614083.AWQR01000017_gene2255 6.47e-72 221.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,4ACMY@80864|Comamonadaceae 28216|Betaproteobacteria Q toluene tolerance family protein ttg2D - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_338875_1 1122951.ATUE01000010_gene297 2.37e-38 138.0 COG1024@1|root,COG1024@2|Bacteria,1RIVB@1224|Proteobacteria,1S80Y@1236|Gammaproteobacteria,3NMHS@468|Moraxellaceae 1236|Gammaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_661162_1 614083.AWQR01000018_gene1825 3.16e-84 254.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2VKZJ@28216|Betaproteobacteria,4AA0F@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM Phosphoserine phosphatase SerB serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_298631_1 397945.Aave_1006 1.35e-88 270.0 COG2518@1|root,COG2518@2|Bacteria,1NMMQ@1224|Proteobacteria,2VH3B@28216|Betaproteobacteria,4ACAP@80864|Comamonadaceae 28216|Betaproteobacteria O Methyltransferase domain - - - - - - - - - - - - Methyltransf_32 k59_446799_1 296591.Bpro_4063 3.73e-39 144.0 COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria,4AB9X@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_446799_2 391735.Veis_0857 3.51e-45 156.0 COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2VKVZ@28216|Betaproteobacteria,4AB82@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1088333_1 1000565.METUNv1_02944 4.54e-167 470.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KV20@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_724840_1 1353529.M899_2030 6.59e-155 455.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2MSS8@213481|Bdellovibrionales,2WKYU@28221|Deltaproteobacteria 213481|Bdellovibrionales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_262011_1 640081.Dsui_2215 6.61e-21 85.1 COG2938@1|root,COG2938@2|Bacteria,1PUKU@1224|Proteobacteria,2VXD6@28216|Betaproteobacteria,2KXEV@206389|Rhodocyclales 206389|Rhodocyclales S Flavinator of succinate dehydrogenase - - - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 k59_262011_2 640081.Dsui_2216 8.03e-49 166.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,2KVDB@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1045923_1 614083.AWQR01000045_gene2055 1.11e-94 281.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,4AA9U@80864|Comamonadaceae 28216|Betaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_135223_1 596154.Alide2_3766 1.03e-12 67.8 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,4A9X7@80864|Comamonadaceae 28216|Betaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_851806_1 1218084.BBJK01000019_gene2013 1.21e-10 60.8 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,1K0JX@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_741018_1 1415780.JPOG01000001_gene517 3.19e-08 60.1 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales 135614|Xanthomonadales S transporter oliA - - - - - - - - - - - OPT k59_1029275_1 1403819.BATR01000124_gene4391 2.26e-79 253.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_851820_1 1000565.METUNv1_03597 3.86e-19 85.9 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2VK5U@28216|Betaproteobacteria,2KYM2@206389|Rhodocyclales 206389|Rhodocyclales C Sarcosine oxidase, gamma subunit family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_851820_2 1000565.METUNv1_03596 1.21e-60 186.0 COG4311@1|root,COG4311@2|Bacteria,1NA4N@1224|Proteobacteria,2VX6V@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM Sarcosine oxidase, delta subunit, heterotetrameric - - 1.5.3.1 ko:K00304 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxD k59_851820_3 1000565.METUNv1_03595 1.69e-08 54.3 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2VKCE@28216|Betaproteobacteria,2KY7Z@206389|Rhodocyclales 206389|Rhodocyclales E FAD dependent oxidoreductase soxB - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_851822_1 1472716.KBK24_0101295 2.35e-58 193.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,1K367@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_171572_1 903818.KI912268_gene2416 7.72e-70 216.0 COG0081@1|root,COG0081@2|Bacteria,3Y2HX@57723|Acidobacteria 57723|Acidobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_171572_2 1121920.AUAU01000017_gene1255 2.34e-17 77.4 COG0244@1|root,COG0244@2|Bacteria,3Y4N2@57723|Acidobacteria 57723|Acidobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_951655_2 522306.CAP2UW1_0327 3.08e-44 152.0 2B4YM@1|root,31XRK@2|Bacteria,1MY6A@1224|Proteobacteria,2VUKQ@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2894) - - - - - - - - - - - - DUF2894 k59_814063_1 288000.BBta_2696 1.93e-33 126.0 COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2URTW@28211|Alphaproteobacteria,3K6NG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Sugar (and other) transporter - - - ko:K08195 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,MFS_4 k59_814063_2 652103.Rpdx1_4871 1.08e-22 95.1 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,3JWVJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S PrpF protein fldA - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_704811_1 557598.LHK_02922 2.68e-51 182.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,2KQ3G@206351|Neisseriales 206351|Neisseriales V ABC-type RTX toxin transporter, ATPase and permease components Prot1E family - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_236943_2 748280.NH8B_1055 1.35e-40 145.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2VM8T@28216|Betaproteobacteria 28216|Betaproteobacteria O ADP-ribosyl- dinitrogen reductase hydrolase draG2 - - - - - - - - - - - ADP_ribosyl_GH k59_627428_2 614083.AWQR01000003_gene2918 2.22e-48 168.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,4ABKD@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_951684_1 573061.Clocel_4008 7.81e-18 89.7 COG0270@1|root,COG0270@2|Bacteria,1TSNX@1239|Firmicutes,2490C@186801|Clostridia,36DIW@31979|Clostridiaceae 186801|Clostridia H PFAM C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_319572_1 1123504.JQKD01000024_gene347 1.1e-77 236.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VHTZ@28216|Betaproteobacteria,4AAHA@80864|Comamonadaceae 28216|Betaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_594721_1 1000565.METUNv1_03749 1.54e-232 656.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria,2KUAM@206389|Rhodocyclales 206389|Rhodocyclales M Polysaccharide chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_704840_1 1198452.Jab_1c09060 2.6e-96 302.0 COG1506@1|root,COG1506@2|Bacteria,1N75C@1224|Proteobacteria,2VPE6@28216|Betaproteobacteria,472S9@75682|Oxalobacteraceae 28216|Betaproteobacteria E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 k59_319577_1 1000565.METUNv1_02333 2.17e-90 278.0 COG4243@1|root,COG4243@2|Bacteria,1MW9C@1224|Proteobacteria,2VPG2@28216|Betaproteobacteria,2KU9P@206389|Rhodocyclales 206389|Rhodocyclales S Vitamin k epoxide reductase - - - - - - - - - - - - - k59_236975_1 59538.XP_005978202.1 2.24e-54 192.0 COG0160@1|root,KOG1404@2759|Eukaryota,3AJUX@33154|Opisthokonta,3BY4E@33208|Metazoa,3E72K@33213|Bilateria,48SPM@7711|Chordata,49P7C@7742|Vertebrata,3JQEW@40674|Mammalia,4JCC3@91561|Cetartiodactyla 2759|Eukaryota E transaminase 1, mitochondrial-like - - - - - - - - - - - - Aminotran_3 k59_319587_1 1121957.ATVL01000007_gene1656 5.83e-10 59.3 COG4805@1|root,COG4805@2|Bacteria,4NGUZ@976|Bacteroidetes,47QE8@768503|Cytophagia 976|Bacteroidetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1132400_1 243365.CV_2303 2.53e-54 192.0 COG1506@1|root,COG1506@2|Bacteria,1N75C@1224|Proteobacteria 1224|Proteobacteria E Peptidase S9, prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_419053_1 1198452.Jab_2c19510 3.66e-32 121.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,473MT@75682|Oxalobacteraceae 28216|Betaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_419053_2 999541.bgla_1g22840 3.52e-42 139.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,1K8J4@119060|Burkholderiaceae 28216|Betaproteobacteria J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_419053_3 1349767.GJA_3456 4.49e-06 47.4 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,472W7@75682|Oxalobacteraceae 28216|Betaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_495750_1 991.IW20_15050 9.28e-60 191.0 COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,4NFYC@976|Bacteroidetes,1HYNT@117743|Flavobacteriia,2NTV2@237|Flavobacterium 976|Bacteroidetes KL Methyltransferase ada - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,HTH_18,Methyltransf_1N k59_495750_2 620914.JH621298_gene3446 1.86e-13 68.9 COG0596@1|root,COG0596@2|Bacteria,4NN9S@976|Bacteroidetes,1I4NH@117743|Flavobacteriia 976|Bacteroidetes S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1099418_1 257313.BP3399 3.14e-20 82.8 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,3T4S6@506|Alcaligenaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - zf-CHCC k59_1099418_2 1454004.AW11_01202 2.21e-63 205.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1KQET@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_704888_1 700598.Niako_6234 2.58e-06 48.5 COG0534@1|root,COG0534@2|Bacteria,4NDUF@976|Bacteroidetes,1IQJT@117747|Sphingobacteriia 976|Bacteroidetes V Mate efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_392115_1 360094.PXO_04606 6.61e-14 70.1 COG2199@1|root,COG3706@2|Bacteria,1RJSG@1224|Proteobacteria,1T1N7@1236|Gammaproteobacteria,1X7JA@135614|Xanthomonadales 135614|Xanthomonadales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_814157_2 1000565.METUNv1_02754 1.75e-80 245.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2VQ64@28216|Betaproteobacteria,2KW6G@206389|Rhodocyclales 206389|Rhodocyclales N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_851973_2 1121920.AUAU01000010_gene19 3.38e-55 173.0 COG0261@1|root,COG0261@2|Bacteria,3Y5MQ@57723|Acidobacteria 57723|Acidobacteria J Ribosomal prokaryotic L21 protein - - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_887521_1 1198452.Jab_2c02840 1.72e-29 111.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,472J2@75682|Oxalobacteraceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_887521_2 1198452.Jab_2c02850 1.8e-35 130.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2VIFF@28216|Betaproteobacteria,4728T@75682|Oxalobacteraceae 28216|Betaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_741221_1 1123392.AQWL01000010_gene2291 8.36e-58 195.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria 28216|Betaproteobacteria U PFAM ABC-1 domain protein - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1132470_1 1123508.JH636442_gene4401 2.95e-102 310.0 COG3497@1|root,COG3497@2|Bacteria 2|Bacteria S Phage tail sheath protein subtilisin-like domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_565100_2 365044.Pnap_3710 1.07e-26 109.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,4A9UF@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1099448_1 438753.AZC_0194 1.31e-15 77.0 COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3EYAG@335928|Xanthobacteraceae 28211|Alphaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg k59_1099448_2 522306.CAP2UW1_3438 8.87e-69 209.0 COG0784@1|root,COG0784@2|Bacteria,1QVBY@1224|Proteobacteria,2VRK5@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_565107_1 338969.Rfer_1795 5.07e-143 415.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,4AAWB@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_137697_1 748247.AZKH_2372 3.73e-72 235.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,2W15Y@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 k59_421593_2 155515.JP36_10175 6.94e-40 139.0 2BZMR@1|root,2ZTY5@2|Bacteria,1RHEP@1224|Proteobacteria,1S6ME@1236|Gammaproteobacteria,1Y7AS@135625|Pasteurellales 135625|Pasteurellales L Protein of unknown function (DUF1804) - - - - - - - - - - - - DUF1804 k59_421593_3 269482.Bcep1808_1307 6e-59 199.0 COG5362@1|root,COG5362@2|Bacteria,1N1KT@1224|Proteobacteria,2VJWB@28216|Betaproteobacteria,1KC73@119060|Burkholderiaceae 28216|Betaproteobacteria S TIGRFAM Phage - - - - - - - - - - - - - k59_744523_1 1454004.AW11_00947 9.24e-106 316.0 COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2VIXB@28216|Betaproteobacteria 28216|Betaproteobacteria EGP major facilitator superfamily - - - - - - - - - - - - MFS_4 k59_890459_2 614083.AWQR01000020_gene191 2.01e-107 315.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VKPP@28216|Betaproteobacteria,4ABCQ@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF k59_30465_1 1004785.AMBLS11_03555 3.68e-07 52.8 28TMI@1|root,2ZFV4@2|Bacteria,1R9YK@1224|Proteobacteria,1S221@1236|Gammaproteobacteria,466IE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Spondin_N - - - - - - - - - - - - Spond_N k59_30465_2 156578.ATW7_15754 2.56e-25 104.0 28TMI@1|root,30GG2@2|Bacteria,1RE0D@1224|Proteobacteria,1S0JA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Spond_N k59_30471_1 1219031.BBJR01000069_gene1078 6.31e-50 172.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2VNMJ@28216|Betaproteobacteria,4AGMK@80864|Comamonadaceae 28216|Betaproteobacteria E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_421617_1 1198452.Jab_2c05560 2.46e-112 339.0 COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,47375@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase yjcC - - - - - - - - - - - CBS,EAL,GGDEF k59_890534_2 1123503.KB908056_gene1713 0.000299 45.8 COG2165@1|root,COG2165@2|Bacteria 2|Bacteria NU general secretion pathway protein lspI - - ko:K02246,ko:K02457,ko:K02458 ko03070,ko05111,map03070,map05111 M00331,M00429 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSI k59_239606_1 864051.BurJ1DRAFT_2090 1.87e-112 339.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1101357_1 1218352.B597_014445 7.55e-51 176.0 COG2327@1|root,COG2327@2|Bacteria,1MXWP@1224|Proteobacteria,1RRDB@1236|Gammaproteobacteria,1Z0EH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Polysaccharide pyruvyl transferase wcaK - - ko:K16710 - - - - ko00000 - - iECSF_1327.ECSF_1934,iSBO_1134.SBO_0872 PS_pyruv_trans k59_137770_1 1502852.FG94_00138 3.07e-54 185.0 COG1835@1|root,COG1835@2|Bacteria,1R4CU@1224|Proteobacteria,2VP15@28216|Betaproteobacteria,476DG@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_421669_1 1410628.JNKS01000019_gene1289 2.27e-35 129.0 COG0463@1|root,COG0463@2|Bacteria,1TRRK@1239|Firmicutes,24CHM@186801|Clostridia,27UBN@186928|unclassified Lachnospiraceae 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_137792_1 1211112.ALJC01000093_gene1367 6.75e-94 302.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_174712_1 338969.Rfer_3760 7.79e-113 355.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,4ACE6@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_103508_1 1357279.N018_08560 7.75e-16 76.3 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,1Z68X@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S N-terminal domain of oxidoreductase yfmJ - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_103508_2 1144319.PMI16_04627 1.79e-30 118.0 COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2VJH6@28216|Betaproteobacteria 28216|Betaproteobacteria K aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2,GntR k59_1101390_1 929703.KE386491_gene3892 1e-19 90.5 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes,47KA7@768503|Cytophagia 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1101390_2 929703.KE386491_gene3821 1.49e-13 71.6 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,47Y3E@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_922008_1 1100721.ALKO01000031_gene116 7.39e-198 554.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,4AAW1@80864|Comamonadaceae 28216|Betaproteobacteria E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metXS - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_174743_1 391615.ABSJ01000045_gene2070 1.23e-32 123.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_174764_1 1217713.F993_01327 3.58e-77 238.0 COG0204@1|root,COG0204@2|Bacteria,1RB47@1224|Proteobacteria,1S31I@1236|Gammaproteobacteria,3NJGJ@468|Moraxellaceae 1236|Gammaproteobacteria I Diacylglycerol acyltransferase - - - - - - - - - - - - Acyltransferase,DAGAT k59_954000_2 1173263.Syn7502_01700 0.000211 43.1 COG0528@1|root,COG0528@2|Bacteria,1G0CR@1117|Cyanobacteria,1GZ4I@1129|Synechococcus 1117|Cyanobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_471683_1 1000565.METUNv1_03714 1.56e-97 287.0 COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,2KUBI@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483,ko:K07774 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1112488_1 640081.Dsui_0028 4.3e-07 50.4 COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,2KVYR@206389|Rhodocyclales 206389|Rhodocyclales M of murein hydrolase - - - - - - - - - - - - LrgB k59_1112488_2 1430440.MGMSRv2_0168 5.21e-28 112.0 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,2TW6S@28211|Alphaproteobacteria,2JST6@204441|Rhodospirillales 204441|Rhodospirillales T diguanylate cyclase - - - - - - - - - - - - CHASE3,GGDEF k59_611640_1 666681.M301_0510 3e-14 70.5 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KN77@206350|Nitrosomonadales 206350|Nitrosomonadales T Forkhead associated domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_611640_2 583345.Mmol_0503 2.09e-63 202.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KNQP@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM Protein phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2,SpoIIE k59_755680_1 1217720.ALOX01000025_gene1111 2.96e-41 149.0 COG0477@1|root,COG2814@2|Bacteria,1MVVW@1224|Proteobacteria,2TVQU@28211|Alphaproteobacteria,2JVKQ@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_755680_2 1144672.F966_03162 3.09e-34 124.0 28TBT@1|root,2ZFK9@2|Bacteria,1QPYG@1224|Proteobacteria,1TNQV@1236|Gammaproteobacteria,3NR4B@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_721035_2 1123229.AUBC01000004_gene3020 2.32e-218 610.0 COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,2U48T@28211|Alphaproteobacteria,3JZT5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria D ATPase of the PP-loop superfamily implicated in cell cycle control - - - - - - - - - - - - His_biosynth k59_793321_1 159087.Daro_1293 5.26e-121 352.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,2KUD7@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_7139_1 1121033.AUCF01000001_gene2554 4.66e-54 184.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_755688_1 497321.C664_03170 1.5e-62 209.0 COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,2VK1M@28216|Betaproteobacteria,2KUAQ@206389|Rhodocyclales 206389|Rhodocyclales S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - VWA_CoxE k59_1082852_1 1122951.ATUE01000005_gene2244 3.33e-106 330.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,3NJFY@468|Moraxellaceae 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164 PBP1_TM,Transgly,Transpeptidase,UB2H k59_900840_1 269482.Bcep1808_6016 6.77e-118 349.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2VHMG@28216|Betaproteobacteria,1K5C0@119060|Burkholderiaceae 28216|Betaproteobacteria C protein alpha chain nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_257897_1 391735.Veis_1177 6.51e-163 485.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,4ADF5@80864|Comamonadaceae 28216|Betaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - DUF3883,Helicase_C,ResIII,SNF2_N k59_1112510_1 309801.trd_A0155 2.26e-13 73.2 COG2197@1|root,COG3170@1|root,COG2197@2|Bacteria,COG3170@2|Bacteria,2G80G@200795|Chloroflexi,27XVP@189775|Thermomicrobia 189775|Thermomicrobia T Two component transcriptional regulator, LuxR family - - - - - - - - - - - - Response_reg k59_1112510_2 1408164.MOLA814_01832 1.87e-48 169.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KQ7I@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_684366_1 365046.Rta_31580 1.2e-88 266.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,4AAKJ@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1082864_2 760117.JN27_05360 7.38e-13 67.4 COG4968@1|root,COG4968@2|Bacteria,1PSJP@1224|Proteobacteria,2WCMT@28216|Betaproteobacteria,477X9@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type IV minor pilin ComP, DNA uptake sequence receptor - - - - - - - - - - - - ComP_DUS,N_methyl k59_471713_1 221288.JH992901_gene1950 2.43e-49 162.0 COG0745@1|root,COG0745@2|Bacteria,1GQIK@1117|Cyanobacteria 1117|Cyanobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1082868_1 1120977.JHUX01000008_gene432 1.11e-48 166.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,3NJ6D@468|Moraxellaceae 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1082868_2 640132.Srot_0767 2.74e-06 45.1 COG1773@1|root,COG1773@2|Bacteria,2GQUH@201174|Actinobacteria 201174|Actinobacteria C Belongs to the rubredoxin family alkG - - - - - - - - - - - Rubredoxin k59_332691_1 95619.PM1_0214100 4.1e-16 78.2 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_332691_2 1198452.Jab_2c16960 5.37e-37 132.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2VP9R@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM peptidase M19 renal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_900852_2 1226994.AMZB01000122_gene2712 4.98e-74 223.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1YFSV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_5014 PRA-CH,PRA-PH k59_7162_1 614083.AWQR01000006_gene342 1.34e-118 345.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,4AAVN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_684375_1 1349785.BAUG01000009_gene731 7.26e-22 100.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,1HWJJ@117743|Flavobacteriia 976|Bacteroidetes P Large extracellular alpha-helical protein - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2 k59_793352_1 1453500.AT05_00660 4.6e-51 180.0 COG0488@1|root,COG0488@2|Bacteria,4NG1W@976|Bacteroidetes,1HWY2@117743|Flavobacteriia 976|Bacteroidetes S of ABC transporters with duplicated ATPase - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_900857_1 1122605.KB893631_gene3894 7.11e-13 73.6 COG4372@1|root,COG4372@2|Bacteria,4NTCH@976|Bacteroidetes,1J0SD@117747|Sphingobacteriia 976|Bacteroidetes S Transposase - - - - - - - - - - - - - k59_219371_1 1000565.METUNv1_01394 6.01e-243 685.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales 206389|Rhodocyclales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_219371_2 1000565.METUNv1_01396 4.63e-274 753.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,2KUJT@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_332701_1 765911.Thivi_4042 5.39e-48 175.0 2EY8D@1|root,33RGX@2|Bacteria,1NTUD@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_332701_2 1283300.ATXB01000001_gene1517 9.25e-112 339.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups pimB GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346,3.2.1.8 ko:K01181,ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_332701_3 765913.ThidrDRAFT_0061 3.77e-16 80.9 COG1216@1|root,COG5610@1|root,COG1216@2|Bacteria,COG5610@2|Bacteria,1Q4T5@1224|Proteobacteria,1S4BJ@1236|Gammaproteobacteria,1WYHC@135613|Chromatiales 135613|Chromatiales M Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Glycos_transf_2 k59_900862_1 1000565.METUNv1_00763 4.08e-126 365.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,2KUAU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_611674_1 1121895.Q765_14465 1.03e-31 124.0 COG0438@1|root,COG0438@2|Bacteria,4NKNB@976|Bacteroidetes,1I3JP@117743|Flavobacteriia,2NV2K@237|Flavobacterium 976|Bacteroidetes M Glycosyl transferases group 1 - - - ko:K12989 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_113910_1 395495.Lcho_0109 4.4e-21 95.1 COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,2WEZZ@28216|Betaproteobacteria,1KNBN@119065|unclassified Burkholderiales 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_863217_1 1000565.METUNv1_03677 1.38e-112 339.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,2KVV7@206389|Rhodocyclales 206389|Rhodocyclales J glutaminyl-tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_113915_1 160492.XF_1574 2.65e-30 119.0 COG2369@1|root,COG2369@2|Bacteria,1RFUM@1224|Proteobacteria,1SYUW@1236|Gammaproteobacteria,1X8FC@135614|Xanthomonadales 135614|Xanthomonadales S to GI 1075358 (percent identity 34 query alignment coverage 98.2 subject alignment coverage 61.7 ) - - - - - - - - - - - - Phage_Mu_F k59_1082907_1 880071.Fleli_1960 3.82e-38 142.0 COG1232@1|root,COG3349@1|root,COG1232@2|Bacteria,COG3349@2|Bacteria,4NJWX@976|Bacteroidetes,47KZG@768503|Cytophagia 976|Bacteroidetes H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_1082907_2 880071.Fleli_1959 3.38e-25 111.0 COG2208@1|root,COG2208@2|Bacteria,4P3GK@976|Bacteroidetes 976|Bacteroidetes KT Serine phosphatase RsbU regulator of sigma subunit - - - - - - - - - - - - SpoIIE k59_721087_1 1000565.METUNv1_03448 2.08e-109 320.0 COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,2VKMF@28216|Betaproteobacteria,2KX8T@206389|Rhodocyclales 206389|Rhodocyclales P Formate/nitrite transporter - - - ko:K06212 - - - - ko00000,ko02000 1.A.16.1.1,1.A.16.1.3 - - Form_Nir_trans k59_113924_1 159087.Daro_1662 7.11e-112 346.0 COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WGYZ@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,SBP_bac_3 k59_1042953_1 1454004.AW11_00914 3.91e-14 66.2 COG3093@1|root,COG3093@2|Bacteria,1N2BD@1224|Proteobacteria,2VVV1@28216|Betaproteobacteria 28216|Betaproteobacteria K Helix-turn-helix - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_1042953_2 1100720.ALKN01000045_gene317 1.26e-45 148.0 COG3549@1|root,COG3549@2|Bacteria,1MZ4I@1224|Proteobacteria,2VW45@28216|Betaproteobacteria,4AJK2@80864|Comamonadaceae 28216|Betaproteobacteria S RelE-like toxin of type II toxin-antitoxin system HigB - - - - - - - - - - - - HigB-like_toxin k59_1042953_3 748247.AZKH_1695 4.6e-39 141.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VICV@28216|Betaproteobacteria,2KUY2@206389|Rhodocyclales 206389|Rhodocyclales L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_863237_1 483219.LILAB_17770 1.64e-33 130.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria,2YWA0@29|Myxococcales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_863237_2 273068.TTE1475 1.72e-31 120.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_934183_1 640081.Dsui_3462 1.05e-95 287.0 COG0715@1|root,COG0715@2|Bacteria,1PDWW@1224|Proteobacteria,2VIDB@28216|Betaproteobacteria,2KZRX@206389|Rhodocyclales 206389|Rhodocyclales P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_190076_2 1307761.L21SP2_0038 2.8e-23 98.6 COG5497@1|root,COG5497@2|Bacteria,2J7E8@203691|Spirochaetes 203691|Spirochaetes S Predicted secreted protein (DUF2259) - - - - - - - - - - - - DUF2259 k59_471760_1 1121015.N789_12945 4.7e-23 98.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X5K1@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_471760_2 1198452.Jab_1c20610 2.05e-55 184.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_219390_1 76114.ebA6102 3.35e-144 422.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,2KU7H@206389|Rhodocyclales 206389|Rhodocyclales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_442699_1 316067.Geob_0980 2.07e-35 141.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria 1224|Proteobacteria E Transglutaminase-like - - - - - - - - - - - - Transglut_core k59_80489_1 1089547.KB913013_gene3944 6.59e-25 108.0 COG1874@1|root,COG2911@1|root,COG3209@1|root,COG3656@1|root,COG1874@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3656@2|Bacteria,4PKBQ@976|Bacteroidetes,47XXU@768503|Cytophagia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,SdrD_B,SprB k59_335008_1 1122951.ATUE01000005_gene2206 2.93e-94 302.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,3NIFC@468|Moraxellaceae 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_366847_1 640081.Dsui_3038 7.39e-51 174.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KVU3@206389|Rhodocyclales 206389|Rhodocyclales C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_366847_2 159087.Daro_0962 6.14e-30 119.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,2KUBM@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_473245_1 1121033.AUCF01000038_gene609 1.89e-29 118.0 COG0457@1|root,COG0457@2|Bacteria,1R6E5@1224|Proteobacteria,2TTK5@28211|Alphaproteobacteria,2JSU2@204441|Rhodospirillales 204441|Rhodospirillales S Tetratricopeptide repeat - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - - k59_45125_1 331869.BAL199_25429 4.76e-43 157.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,4BPQC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C TIGRFAM NADH-quinone oxidoreductase, chain G nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C k59_45125_2 570952.ATVH01000015_gene1557 1.44e-19 87.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,2JPWU@204441|Rhodospirillales 204441|Rhodospirillales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_366850_1 187272.Mlg_2185 1.25e-53 189.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_578385_1 1000565.METUNv1_00456 3.36e-93 280.0 COG1891@1|root,COG1891@2|Bacteria,1RGX0@1224|Proteobacteria,2VRHF@28216|Betaproteobacteria,2KXEN@206389|Rhodocyclales 206389|Rhodocyclales S 4-HFC-P synthase - - - - - - - - - - - - 4HFCP_synth k59_794976_2 1095769.CAHF01000011_gene2104 6.39e-14 70.1 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,472N4@75682|Oxalobacteraceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1085403_1 1000565.METUNv1_03671 1.99e-108 351.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_1009181_1 62928.azo0115 2.8e-62 193.0 COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,2KW8E@206389|Rhodocyclales 206389|Rhodocyclales I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_115403_2 522306.CAP2UW1_3906 2.22e-93 295.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KR9G@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain napA - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_151124_1 3218.PP1S43_18V6.1 1.42e-49 179.0 COG0642@1|root,KOG0519@2759|Eukaryota,37ZNG@33090|Viridiplantae,3GPF0@35493|Streptophyta 35493|Streptophyta G Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_402085_1 365044.Pnap_1291 1.27e-152 436.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VJFX@28216|Betaproteobacteria,4AAX2@80864|Comamonadaceae 28216|Betaproteobacteria C Alcohol dehydrogenase GroES domain protein - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_657092_1 1095769.CAHF01000013_gene3344 4.93e-38 134.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,4731T@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_335102_1 272134.KB731324_gene890 1.99e-08 62.8 COG2931@1|root,COG3210@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales 1117|Cyanobacteria QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Cadherin_3,Calx-beta,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS k59_1009190_1 614083.AWQR01000031_gene2609 7.21e-56 185.0 COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,2VHIB@28216|Betaproteobacteria,4AA1D@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2331) - - - - - - - - - - - - DUF2331 k59_1009190_2 1121116.KB894765_gene608 2.72e-07 50.1 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VH4A@28216|Betaproteobacteria,4AAGC@80864|Comamonadaceae 28216|Betaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_45167_1 399795.CtesDRAFT_PD5385 7.27e-12 65.9 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,4AAWG@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family urtC - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_742238_3 795666.MW7_0990 1.94e-37 126.0 2D3KU@1|root,32R6F@2|Bacteria,1MZ1Z@1224|Proteobacteria,2VTVC@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_952408_1 1122951.ATUE01000008_gene56 4.96e-127 370.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,3NJV1@468|Moraxellaceae 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_952408_2 1122951.ATUE01000008_gene57 4.67e-43 152.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,3NKJJ@468|Moraxellaceae 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_705660_1 1458275.AZ34_12450 2.79e-106 322.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,4AAW3@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_65052_1 1000565.METUNv1_01009 4.53e-165 486.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KUV9@206389|Rhodocyclales 206389|Rhodocyclales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_888419_1 1123248.KB893324_gene1688 2.9e-39 145.0 28JFD@1|root,2Z99B@2|Bacteria,4NFQJ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - OprD k59_237844_1 243365.CV_2953 2.67e-55 195.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KSHZ@206351|Neisseriales 206351|Neisseriales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_65060_1 1000565.METUNv1_00702 3.5e-157 455.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_705683_1 1122951.ATUE01000007_gene602 1.55e-22 97.1 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,1RP5M@1236|Gammaproteobacteria,3NK44@468|Moraxellaceae 1236|Gammaproteobacteria V MatE norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_705683_2 1177154.Y5S_03497 7.41e-31 118.0 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,1S133@1236|Gammaproteobacteria,1XJZN@135619|Oceanospirillales 135619|Oceanospirillales M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_N k59_320463_1 946483.Cenrod_0440 1.09e-73 246.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,4ABX9@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K11711 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9 k59_419949_1 743720.Psefu_4198 4.02e-10 62.0 COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,1RZIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_419949_2 204773.HEAR1445 3.22e-19 84.7 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VJCQ@28216|Betaproteobacteria,473MK@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_774384_1 1120999.JONM01000002_gene617 8.34e-23 95.5 COG0834@1|root,COG0834@2|Bacteria,1N2CF@1224|Proteobacteria,2W0ES@28216|Betaproteobacteria 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_814891_2 1000565.METUNv1_03765 1.47e-31 120.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VJVY@28216|Betaproteobacteria,2KY04@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_419951_1 614083.AWQR01000029_gene2162 2.44e-113 340.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,4AC6F@80864|Comamonadaceae 28216|Betaproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_628072_1 614083.AWQR01000014_gene2448 7.44e-58 187.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,4ABMC@80864|Comamonadaceae 28216|Betaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_419961_2 298386.PBPRB1111 7.2e-75 239.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1XTUN@135623|Vibrionales 135623|Vibrionales C COG1012 NAD-dependent aldehyde dehydrogenases mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_814901_1 575540.Isop_0311 3.67e-94 289.0 COG4102@1|root,COG4102@2|Bacteria,2IX5T@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_101505_1 383407.XOC_3262 3.46e-82 266.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1X4BR@135614|Xanthomonadales 135614|Xanthomonadales V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain raxB2 - - ko:K13409 ko02010,ko04626,map02010,map04626 M00339 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_705716_1 1458427.BAWN01000013_gene769 2.27e-69 220.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2VNAZ@28216|Betaproteobacteria,4AAES@80864|Comamonadaceae 28216|Betaproteobacteria M Nucleotidyl transferase - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_28850_1 1000565.METUNv1_00276 2.08e-61 191.0 COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,2KX1I@206389|Rhodocyclales 206389|Rhodocyclales S cobalamin (vitamin B12) biosynthesis CbiX protein - - 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiX k59_28850_2 1000565.METUNv1_00274 1.78e-14 70.5 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales 28216|Betaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain epsR - - - - - - - - - - - GerE,Response_reg k59_1133366_1 697282.Mettu_2592 2.17e-22 94.7 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1XETG@135618|Methylococcales 1236|Gammaproteobacteria S PFAM Transposase, IS801 IS1294 - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1133366_2 1229205.BUPH_08508 4.08e-84 255.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_237926_1 1123247.AUIJ01000019_gene11 1.04e-24 108.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - CHASE,GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,PHY,Response_reg,dCache_1 k59_496994_1 1134474.O59_003367 7.74e-49 170.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1FFRU@10|Cellvibrio 1236|Gammaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1133381_1 1297863.APJF01000009_gene239 7.82e-14 72.4 COG0582@1|root,COG0582@2|Bacteria,1R3TM@1224|Proteobacteria,2TS94@28211|Alphaproteobacteria,3JUDH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_1133381_2 1005048.CFU_1704 3.15e-12 67.0 COG1802@1|root,COG1802@2|Bacteria,1R90Y@1224|Proteobacteria,2VKEN@28216|Betaproteobacteria,472FA@75682|Oxalobacteraceae 28216|Betaproteobacteria K PFAM Bacterial regulatory proteins, gntR family, FCD domain gntR3 - - - - - - - - - - - FCD,GntR k59_28882_1 929556.Solca_2233 2.12e-79 246.0 COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes 976|Bacteroidetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11 k59_172742_1 1239962.C943_04482 8.51e-96 295.0 COG0318@1|root,COG0318@2|Bacteria,4PKQG@976|Bacteroidetes,47K42@768503|Cytophagia 976|Bacteroidetes IQ GH3 auxin-responsive promoter - - - - - - - - - - - - GH3 k59_920389_1 795666.MW7_1522 4.21e-52 184.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,1K2CU@119060|Burkholderiaceae 28216|Betaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_420034_1 765913.ThidrDRAFT_1008 2.21e-41 145.0 COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,1S2ZY@1236|Gammaproteobacteria,1WY2I@135613|Chromatiales 135613|Chromatiales C PFAM HupH hydrogenase expression protein, C-terminal conserved region - - - ko:K03618 - - - - ko00000 - - - HupH_C k59_420034_2 1054217.TALC_01081 8.76e-11 60.1 COG1773@1|root,arCOG04391@2157|Archaea,2Y1AB@28890|Euryarchaeota 28890|Euryarchaeota C Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - - - - - - - - - - Rubredoxin k59_420034_3 1121127.JAFA01000094_gene2973 3.74e-24 98.2 COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2VUNU@28216|Betaproteobacteria,1K8UM@119060|Burkholderiaceae 28216|Betaproteobacteria C [NiFe]-hydrogenase assembly, chaperone, HybE hoxT - - - - - - - - - - - NiFe-hyd_HybE,Rubredoxin k59_991156_1 278957.ABEA03000137_gene2635 6.1e-117 354.0 COG1164@1|root,COG1164@2|Bacteria,46UYD@74201|Verrucomicrobia,3K7VF@414999|Opitutae 414999|Opitutae E Oligopeptidase F - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_420036_1 358220.C380_14805 1.29e-31 118.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VIZP@28216|Betaproteobacteria,4A9RC@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_420036_2 358220.C380_14800 1.26e-30 116.0 COG0491@1|root,COG0491@2|Bacteria,1NGQE@1224|Proteobacteria,2VH3G@28216|Betaproteobacteria,4AAP0@80864|Comamonadaceae 28216|Betaproteobacteria S beta-lactamase - - - - - - - - - - - - Lactamase_B k59_281089_1 1000565.METUNv1_02733 8.93e-152 432.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,2KV89@206389|Rhodocyclales 206389|Rhodocyclales M pfkB family carbohydrate kinase - - 2.7.1.167 ko:K21344 ko00540,map00540 M00064 R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_1030540_2 1444770.AF72_00925 5.59e-36 134.0 COG1835@1|root,COG1835@2|Bacteria,1RKTJ@1224|Proteobacteria,1S96U@1236|Gammaproteobacteria,1X8EK@135614|Xanthomonadales 135614|Xanthomonadales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_136250_1 857087.Metme_1140 2.86e-33 132.0 COG2199@1|root,COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales 135618|Methylococcales T Diguanylate cyclase phosphodiesterase with PAS PAC - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE1,PAS,PAS_3,PAS_9 k59_237985_1 614083.AWQR01000003_gene2938 6.02e-83 263.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,4AA59@80864|Comamonadaceae 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_566032_2 1232683.ADIMK_2648 8.02e-13 66.6 28N2X@1|root,2ZB8P@2|Bacteria,1R4KJ@1224|Proteobacteria 1224|Proteobacteria S sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7 - - - - - - - - - - - - - k59_497096_1 1157708.KB907450_gene6173 2.68e-90 286.0 COG1511@1|root,COG1511@2|Bacteria,1R6MB@1224|Proteobacteria,2VKRK@28216|Betaproteobacteria,4AGFT@80864|Comamonadaceae 28216|Betaproteobacteria S domain protein - - - ko:K01421 - - - - ko00000 - - - ABC2_membrane_3 k59_65234_1 864073.HFRIS_014634 9.43e-44 149.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,47247@75682|Oxalobacteraceae 28216|Betaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_65234_2 375286.mma_2512 3.11e-38 134.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,473K0@75682|Oxalobacteraceae 28216|Betaproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_853169_1 258052.JNYV01000008_gene3700 8.27e-64 210.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_991209_2 1268622.AVS7_02029 4.69e-66 209.0 COG0583@1|root,COG0583@2|Bacteria,1R5ZT@1224|Proteobacteria,2VNWF@28216|Betaproteobacteria,4ACNK@80864|Comamonadaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_281140_2 1050202.KB913024_gene2349 5.66e-24 101.0 COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,407ZJ@622450|Actinopolysporales 201174|Actinobacteria J RNA methyltransferase rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_853180_1 640081.Dsui_1342 1.37e-32 115.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,2KWM2@206389|Rhodocyclales 206389|Rhodocyclales O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_420111_1 28229.ND2E_3291 9.11e-45 156.0 COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,1RRIB@1236|Gammaproteobacteria,2Q6EX@267889|Colwelliaceae 1236|Gammaproteobacteria E Proline racemase - - 5.1.1.4 ko:K01777 ko00330,ko01100,map00330,map01100 - R01255 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase k59_320639_1 1095769.CAHF01000003_gene1041 7.63e-70 231.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,472H8@75682|Oxalobacteraceae 28216|Betaproteobacteria U Secretin and TonB N terminus short domain pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_705854_1 404589.Anae109_0236 1.13e-19 88.6 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2Z2NY@29|Myxococcales 28221|Deltaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin poR - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1133513_1 1000565.METUNv1_00477 1.35e-120 370.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KY21@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Response_reg k59_855960_1 56107.Cylst_3538 1.18e-91 293.0 COG0826@1|root,COG0826@2|Bacteria,1G3NG@1117|Cyanobacteria,1HM59@1161|Nostocales 1117|Cyanobacteria O Peptidase family U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32,Peptidase_U32_C k59_855968_1 1000565.METUNv1_01215 2.35e-41 142.0 28JV9@1|root,2Z9K8@2|Bacteria,1MVTX@1224|Proteobacteria,2VP25@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_776960_1 189426.PODO_07185 4.52e-14 78.2 COG1653@1|root,COG1653@2|Bacteria,1U0QV@1239|Firmicutes,4HTIR@91061|Bacilli,26V7V@186822|Paenibacillaceae 91061|Bacilli G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 k59_993284_1 1123504.JQKD01000006_gene1443 4.54e-05 43.5 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,4ADN8@80864|Comamonadaceae 28216|Betaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_993290_1 925409.KI911562_gene899 1.77e-44 155.0 COG3637@1|root,COG3637@2|Bacteria,4NNPF@976|Bacteroidetes,1ISTC@117747|Sphingobacteriia 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_240347_1 999550.KI421507_gene2912 3.27e-36 132.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TTFG@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_283038_2 1223521.BBJX01000007_gene1454 3.67e-57 191.0 COG0515@1|root,COG0589@1|root,COG0515@2|Bacteria,COG0589@2|Bacteria,1MV1P@1224|Proteobacteria,2VM52@28216|Betaproteobacteria,4ACA6@80864|Comamonadaceae 28216|Betaproteobacteria KLT Serine threonine protein kinase - - - - - - - - - - - - Pkinase,Usp k59_629756_2 688245.CtCNB1_1532 5.67e-191 540.0 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,2VN1J@28216|Betaproteobacteria,4AFGT@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - ko:K14059 - - - - ko00000 - - - Arm-DNA-bind_2,Phage_int_SAM_3,Phage_integrase k59_629756_4 1129794.C427_2411 3.61e-09 60.5 2DNGS@1|root,32XES@2|Bacteria,1NCMU@1224|Proteobacteria,1SBMP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_629756_5 5341.XP_007333314.1 6.74e-07 50.8 COG3772@1|root,2S6UW@2759|Eukaryota,3A2UF@33154|Opisthokonta,3P2E0@4751|Fungi,3V5T8@5204|Basidiomycota,22D0G@155619|Agaricomycetes,3W8N6@5338|Agaricales 4751|Fungi O lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_104324_1 1276756.AUEX01000001_gene1102 1.05e-105 313.0 COG3181@1|root,COG3181@2|Bacteria,1R4JE@1224|Proteobacteria,2VJTF@28216|Betaproteobacteria,4ABBU@80864|Comamonadaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_104325_1 398527.Bphyt_6893 1.62e-63 216.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1K311@119060|Burkholderiaceae 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_776984_1 316067.Geob_2130 8.36e-53 181.0 COG0463@1|root,COG0463@2|Bacteria,1RF0J@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase family 2 - - 2.4.1.60 ko:K13005 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_2 k59_856024_1 1000565.METUNv1_02146 7.49e-54 175.0 COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,2KWYS@206389|Rhodocyclales 206389|Rhodocyclales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_954607_1 1121904.ARBP01000002_gene6678 1.4e-36 142.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity srrB - - - - - - - - - - - CBS,HAMP,SpoIIE,dCache_1 k59_1033341_1 596154.Alide2_0044 2.66e-94 301.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,4A9VI@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1033341_2 1100720.ALKN01000028_gene2511 4.5e-14 73.6 COG0845@1|root,COG0845@2|Bacteria,1R4E4@1224|Proteobacteria,2VN9E@28216|Betaproteobacteria,4AH0T@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_653592_1 870187.Thini_3663 9.8e-45 160.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RP7V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF1501,TAT_signal k59_439270_1 1000565.METUNv1_02943 3.4e-125 359.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria,2KV4A@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_653610_1 1118054.CAGW01000009_gene3934 2.12e-139 413.0 COG1231@1|root,COG1231@2|Bacteria,1VM1Q@1239|Firmicutes,4HS2U@91061|Bacilli,26WD3@186822|Paenibacillaceae 91061|Bacilli E Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_755294_1 1323663.AROI01000035_gene1323 4.64e-51 184.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_6648_2 1122951.ATUE01000006_gene1170 6.15e-103 306.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,3NIXX@468|Moraxellaceae 1236|Gammaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system yadG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_6653_1 29581.BW37_00837 7.93e-86 265.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,472XX@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family rsmB_2 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_331857_1 614083.AWQR01000046_gene3318 4.13e-56 185.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2VJAZ@28216|Betaproteobacteria,4AAPV@80864|Comamonadaceae 28216|Betaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_331857_2 614083.AWQR01000046_gene3317 1.85e-19 86.3 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,2VH35@28216|Betaproteobacteria,4AA5N@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar rod assembly protein muramidase FlgJ flgJ - - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_720643_1 1279009.ADICEAN_02139 4.26e-23 103.0 COG1520@1|root,COG1520@2|Bacteria,4PKMD@976|Bacteroidetes,47QM2@768503|Cytophagia 976|Bacteroidetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_6668_1 1000565.METUNv1_02763 7.54e-53 175.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,2KUAX@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase like family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_6668_2 1000565.METUNv1_03093 1.54e-30 121.0 COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,2VPUX@28216|Betaproteobacteria,2KZIN@206389|Rhodocyclales 206389|Rhodocyclales S Lysylphosphatidylglycerol synthase TM region - - - - - - - - - - - - LPG_synthase_TM k59_828808_1 1000565.METUNv1_00191 8.82e-74 235.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,2KV46@206389|Rhodocyclales 206389|Rhodocyclales H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_113397_1 240292.Ava_1029 3.96e-31 126.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3452@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3452@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1HRJ1@1161|Nostocales 1117|Cyanobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - CHASE,GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_331877_1 1000565.METUNv1_01084 7.46e-116 344.0 COG0715@1|root,COG0715@2|Bacteria,1QTVG@1224|Proteobacteria,2VJVD@28216|Betaproteobacteria 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_933723_1 1367847.JCM7686_pAMI4p199 7.07e-59 200.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,2PV07@265|Paracoccus 28211|Alphaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_78899_1 1348583.ATLH01000023_gene642 3.04e-22 100.0 COG5373@1|root,COG5373@2|Bacteria,4NGKV@976|Bacteroidetes,1HZB4@117743|Flavobacteriia,1F7U6@104264|Cellulophaga 976|Bacteroidetes S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_78901_1 1000565.METUNv1_01548 5.61e-97 292.0 COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,2VJ71@28216|Betaproteobacteria,2KVEG@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily rlmM - 2.1.1.186 ko:K06968 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_510565_1 1276756.AUEX01000016_gene1907 3.25e-94 291.0 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria,4AAYD@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM FAD dependent oxidoreductase - - - ko:K07137 - - - - ko00000 - - - Amino_oxidase,Pyr_redox_2 k59_400430_1 1502852.FG94_01296 7.95e-96 293.0 COG2072@1|root,COG2072@2|Bacteria,1QW8X@1224|Proteobacteria 1224|Proteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 k59_510571_1 1249627.D779_3736 1.15e-26 116.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria,1WXP6@135613|Chromatiales 135613|Chromatiales O O-linked N-acetylglucosamine transferase, SPINDLY family - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_364680_1 338969.Rfer_0216 8.36e-106 320.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,4AC26@80864|Comamonadaceae 28216|Betaproteobacteria I Benzoate-CoA ligase family - - 6.2.1.25 ko:K04110 ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120 - R01422 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_400434_1 1323663.AROI01000026_gene1830 7.54e-11 65.1 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_400434_2 1265490.JHVY01000027_gene402 1.55e-21 88.2 COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S YcgL domain-containing protein ycgL - - ko:K09902 - - - - ko00000 - - - YcgL k59_400434_3 65393.PCC7424_4436 8.13e-15 72.0 COG3453@1|root,COG3453@2|Bacteria,1G6UU@1117|Cyanobacteria,3KK19@43988|Cyanothece 1117|Cyanobacteria S Putative phosphatase (DUF442) - - - - - - - - - - - - DUF442 k59_755341_1 338969.Rfer_2796 1.01e-84 258.0 COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2VQZD@28216|Betaproteobacteria,4AAKD@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase k59_900345_1 1000565.METUNv1_02702 1.35e-148 448.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVA4@206389|Rhodocyclales 206389|Rhodocyclales U efflux pump - - - ko:K18138,ko:K18146 ko01501,ko01503,map01501,map01503 M00647,M00649,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.40 - - ACR_tran k59_439383_1 243231.GSU0503 4.34e-09 55.1 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,43V8X@69541|Desulfuromonadales 28221|Deltaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_439383_2 981336.F944_01867 7.22e-130 382.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,3NJIM@468|Moraxellaceae 1236|Gammaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2368 Seryl_tRNA_N,tRNA-synt_2b k59_969590_1 1198452.Jab_2c05820 1.53e-16 79.7 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,473VJ@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_969590_2 1005048.CFU_2446 6.04e-40 140.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,473HF@75682|Oxalobacteraceae 28216|Betaproteobacteria I Squalene/phytoene synthase hpnC - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_1082095_1 1502770.JQMG01000001_gene1493 1.22e-53 176.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,2KKZJ@206350|Nitrosomonadales 206350|Nitrosomonadales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_576787_1 1000565.METUNv1_02539 3.61e-38 130.0 2EFX9@1|root,32YGP@2|Bacteria,1N7MN@1224|Proteobacteria,2VW9F@28216|Betaproteobacteria,2KXDY@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_257460_1 614083.AWQR01000006_gene286 6.57e-114 340.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,4AA4K@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM carboxyl transferase accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_6705_2 1217715.F994_02650 1.91e-12 76.6 COG2831@1|root,COG2831@2|Bacteria,1MXF6@1224|Proteobacteria,1RQJB@1236|Gammaproteobacteria,3NMBZ@468|Moraxellaceae 1236|Gammaproteobacteria U POTRA domain - - - ko:K07326 ko05133,map05133 - - - ko00000,ko00001 - - - POTRA_2,POTRA_3,ShlB k59_576788_1 296591.Bpro_2349 7e-102 303.0 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,2VJFQ@28216|Betaproteobacteria,4AE0P@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_683959_1 379731.PST_2520 2.05e-63 206.0 COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,1RY89@1236|Gammaproteobacteria,1YZTD@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_720689_1 1005048.CFU_4171 4.76e-43 150.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,472SF@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_720689_2 883126.HMPREF9710_01135 1.96e-12 65.9 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,472KX@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_471311_1 1225785.CM001983_gene859 3.71e-22 95.9 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,2JC5T@204037|Dickeya 1236|Gammaproteobacteria M Outer membrane efflux protein oprN2 - - - - - - - - - - - OEP k59_611350_1 1144319.PMI16_01413 9.22e-74 229.0 COG0625@1|root,COG0625@2|Bacteria,1NX28@1224|Proteobacteria,2VQ5Y@28216|Betaproteobacteria 28216|Betaproteobacteria O Glutathione S-transferase yfcF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_4,GST_N,GST_N_3 k59_611350_2 622637.KE124774_gene585 2.28e-49 163.0 2AH4X@1|root,317EK@2|Bacteria,1RHUE@1224|Proteobacteria,2UADH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_148977_1 395494.Galf_0744 2.35e-94 284.0 COG0551@1|root,COG0551@2|Bacteria,1R81P@1224|Proteobacteria,2VV8R@28216|Betaproteobacteria 28216|Betaproteobacteria L Nuclease-related domain - - - - - - - - - - - - NERD k59_683973_1 632245.CLP_1714 1.59e-58 196.0 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,36FPY@31979|Clostridiaceae 186801|Clostridia G Belongs to the mannitol dehydrogenase family. UxaB subfamily uxaB - 1.1.1.58 ko:K00041 ko00040,ko01100,map00040,map01100 M00631 R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_331970_1 1000565.METUNv1_02930 1.53e-136 397.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KUHV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1042604_1 1122951.ATUE01000005_gene2222 1.49e-60 190.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,3NIWU@468|Moraxellaceae 1236|Gammaproteobacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_862735_1 1415780.JPOG01000001_gene2578 2.34e-08 61.6 COG2199@1|root,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,1S0XV@1236|Gammaproteobacteria,1X7WG@135614|Xanthomonadales 135614|Xanthomonadales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_149000_2 1000565.METUNv1_03057 4.88e-41 144.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,2VIZ8@28216|Betaproteobacteria,2KVMB@206389|Rhodocyclales 206389|Rhodocyclales S Beta-lactamase - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_439479_1 1122951.ATUE01000011_gene479 3.65e-66 205.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,3NJSD@468|Moraxellaceae 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_332005_1 381666.H16_B2222 3.36e-123 362.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VI1T@28216|Betaproteobacteria,1K0YT@119060|Burkholderiaceae 28216|Betaproteobacteria S Mo-co oxidoreductase dimerisation domain - - - ko:K17225 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Mo-co_dimer,Oxidored_molyb k59_576820_1 864051.BurJ1DRAFT_0939 5.1e-37 134.0 COG4625@1|root,COG4625@2|Bacteria,1RFJG@1224|Proteobacteria,2WI60@28216|Betaproteobacteria 28216|Betaproteobacteria S pathogenesis - - - - - - - - - - - - - k59_219127_1 1000565.METUNv1_03211 7.94e-163 462.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,2KVMG@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_219127_2 1000565.METUNv1_03212 1.76e-35 122.0 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,2KX70@206389|Rhodocyclales 206389|Rhodocyclales O Hydrogenase assembly chaperone hypC hupF hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_219127_3 1000565.METUNv1_03213 3.17e-07 51.2 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,2KUF2@206389|Rhodocyclales 206389|Rhodocyclales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_332008_1 365044.Pnap_1835 8.2e-33 117.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,4AE0C@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Methionine sulfoxide reductase B msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_332008_2 232721.Ajs_1677 9.27e-38 139.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2VH7S@28216|Betaproteobacteria,4AB0E@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_829893_1 925409.KI911562_gene2394 8.03e-26 109.0 2DSUR@1|root,33HH4@2|Bacteria,4P5D2@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_79783_1 497321.C664_18297 2.44e-39 135.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,2KWBJ@206389|Rhodocyclales 206389|Rhodocyclales I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_863796_1 159087.Daro_0813 6.48e-22 88.6 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,2KX0Y@206389|Rhodocyclales 206389|Rhodocyclales S stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_863796_2 640081.Dsui_1815 5.71e-129 367.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,2KUQK@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the GST superfamily sspA - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N k59_150077_1 1000565.METUNv1_02647 3.77e-35 127.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2VRIC@28216|Betaproteobacteria,2KWEC@206389|Rhodocyclales 206389|Rhodocyclales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_150077_2 1000565.METUNv1_02646 5.42e-163 458.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2VH7A@28216|Betaproteobacteria,2KVFS@206389|Rhodocyclales 206389|Rhodocyclales N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_756165_1 1000565.METUNv1_02966 3.61e-33 123.0 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,2KX4B@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_756165_2 1000565.METUNv1_02966 5.53e-21 89.0 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,2KX4B@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_219682_1 1000565.METUNv1_02486 1.96e-139 413.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,2VSM7@28216|Betaproteobacteria,2KWS4@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_401244_1 83406.HDN1F_07040 3.89e-94 277.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1JANE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family UPF0016 HA62_23750 - - - - - - - - - - - UPF0016 k59_258537_1 365046.Rta_35700 2.02e-48 157.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2VSG7@28216|Betaproteobacteria,4AE42@80864|Comamonadaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_441151_1 85643.Tmz1t_3466 3.44e-86 278.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VIQ6@28216|Betaproteobacteria,2KUJM@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory protein, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_1112961_1 1000565.METUNv1_03664 1.94e-307 853.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,2KU8J@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_934667_2 391008.Smal_2511 2.5e-34 123.0 COG4678@1|root,COG4678@2|Bacteria,1R92U@1224|Proteobacteria,1S23X@1236|Gammaproteobacteria,1X979@135614|Xanthomonadales 135614|Xanthomonadales G Phage lysozyme - - - - - - - - - - - - Phage_lysozyme k59_612115_1 204773.HEAR2425 9.73e-97 299.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2VI47@28216|Betaproteobacteria,475BN@75682|Oxalobacteraceae 28216|Betaproteobacteria U MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_190919_1 159087.Daro_3872 6.29e-33 137.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_1008258_1 522306.CAP2UW1_0729 4.2e-36 135.0 COG0374@1|root,COG0374@2|Bacteria,1R6ND@1224|Proteobacteria,2VQXM@28216|Betaproteobacteria 28216|Betaproteobacteria C Ni,Fe-hydrogenase I large subunit hoxV - - - - - - - - - - - NiFeSe_Hases k59_190935_1 1198452.Jab_1c19180 4.28e-19 91.7 28ITP@1|root,2Z8SK@2|Bacteria,1R6RR@1224|Proteobacteria,2W24F@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_333616_1 1122951.ATUE01000005_gene2084 9.47e-26 100.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,3NKFP@468|Moraxellaceae 1236|Gammaproteobacteria KT Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_472311_1 1286631.X805_20060 1.9e-25 106.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KISZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T chemotaxis sensory transducer - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9 k59_829928_1 640081.Dsui_1701 4.91e-14 69.7 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,2KW5S@206389|Rhodocyclales 206389|Rhodocyclales L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_829928_2 1000565.METUNv1_02593 1.39e-90 288.0 COG1639@1|root,COG3852@1|root,COG1639@2|Bacteria,COG3852@2|Bacteria,1R444@1224|Proteobacteria,2VJPB@28216|Betaproteobacteria,2KZQ9@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HATPase_c,HDOD k59_1043371_1 700598.Niako_6301 3.05e-30 112.0 2DEYG@1|root,2ZPSM@2|Bacteria,4NNJW@976|Bacteroidetes,1ISSQ@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_258562_1 1000565.METUNv1_01292 4.74e-104 322.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_441196_1 1131553.JIBI01000020_gene219 2.63e-18 76.3 2DDM5@1|root,2ZII8@2|Bacteria,1P40F@1224|Proteobacteria,2W552@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_219697_2 1000565.METUNv1_00789 1.34e-75 232.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VWXW@28216|Betaproteobacteria,2KYXT@206389|Rhodocyclales 206389|Rhodocyclales K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_219697_4 1000565.METUNv1_00791 4.27e-14 68.6 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,2VJPQ@28216|Betaproteobacteria,2KWQ5@206389|Rhodocyclales 206389|Rhodocyclales Q Isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase k59_213323_6 29581.BW37_00159 1.93e-112 337.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,2VIGD@28216|Betaproteobacteria,4756E@75682|Oxalobacteraceae 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_213323_7 1070319.CAGGBEG34_610002 2.24e-06 48.1 2EK4U@1|root,33DV9@2|Bacteria,1NGNX@1224|Proteobacteria,2VYPZ@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4224) - - - - - - - - - - - - DUF4224 k59_699282_1 204773.HEAR0556 1.42e-111 327.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,472T9@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_22583_2 398767.Glov_3059 1.91e-46 163.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2WKQV@28221|Deltaproteobacteria,43V5R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_699285_1 76114.p2A75 5.95e-112 333.0 COG3177@1|root,COG3177@2|Bacteria,1MXWY@1224|Proteobacteria,2VMBH@28216|Betaproteobacteria 28216|Betaproteobacteria K filamentation induced by cAMP protein Fic - - - - - - - - - - - - Fic k59_213342_1 1000565.METUNv1_03467 8e-123 362.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,2KUK1@206389|Rhodocyclales 206389|Rhodocyclales MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1095829_1 556269.ACDQ01000017_gene853 6.01e-34 120.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,4741P@75682|Oxalobacteraceae 28216|Betaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1095829_2 1198452.Jab_1c01030 2.59e-79 241.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,472H1@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Permease MlaE ttg2B - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_558822_1 909943.HIMB100_00020610 5.06e-29 115.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,4BPJS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_558822_2 1121033.AUCF01000011_gene1812 1.48e-41 147.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,2JP8E@204441|Rhodospirillales 204441|Rhodospirillales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_21,AAA_23,SMC_N k59_213384_1 1000565.METUNv1_02158 1.22e-119 345.0 COG4221@1|root,COG4221@2|Bacteria,1NTNU@1224|Proteobacteria,2WI8R@28216|Betaproteobacteria 28216|Betaproteobacteria S short chain dehydrogenase - - - - - - - - - - - - adh_short k59_213384_2 1000565.METUNv1_02159 2.48e-82 248.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,2KVZM@206389|Rhodocyclales 206389|Rhodocyclales D ATPase MipZ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - CbiA k59_312784_1 925409.KI911562_gene1796 1.42e-29 121.0 COG4775@1|root,COG4775@2|Bacteria,4NE80@976|Bacteroidetes,1IPP9@117747|Sphingobacteriia 976|Bacteroidetes M Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,POTRA k59_383694_1 397945.Aave_0421 1.25e-17 82.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJE4@28216|Betaproteobacteria,4ACMJ@80864|Comamonadaceae 28216|Betaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_383694_2 397945.Aave_4019 6.68e-05 44.3 COG0778@1|root,COG0778@2|Bacteria,1N95W@1224|Proteobacteria,2VQKR@28216|Betaproteobacteria,4AD68@80864|Comamonadaceae 28216|Betaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_947071_1 296591.Bpro_0491 1.97e-27 102.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,4AE21@80864|Comamonadaceae 28216|Betaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_947071_2 1458275.AZ34_17305 1.07e-67 208.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,4AB1M@80864|Comamonadaceae 28216|Betaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_623350_1 543728.Vapar_4282 8.14e-104 316.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,4A9JW@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_312813_1 1144342.PMI40_01678 5.23e-38 139.0 COG3500@1|root,COG3500@2|Bacteria,1R6WJ@1224|Proteobacteria,2VNXA@28216|Betaproteobacteria 28216|Betaproteobacteria S Late control gene D protein - - - - - - - - - - - - - k59_312813_2 1123508.JH636442_gene4394 2.22e-10 62.8 COG1652@1|root,COG1652@2|Bacteria 2|Bacteria S positive regulation of growth rate ygaU GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896 - ko:K21687,ko:K21688,ko:K21691 - - - - ko00000 - GH23 - BON,LysM k59_947073_1 1151122.AQYD01000005_gene3274 3.05e-103 320.0 2EYX9@1|root,33S42@2|Bacteria,2IABS@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - Phage_capsid k59_213477_1 865938.Weevi_0850 2.04e-08 57.0 COG0204@1|root,COG0204@2|Bacteria,4NG5R@976|Bacteroidetes,1HXST@117743|Flavobacteriia 976|Bacteroidetes I acyltransferase plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_213480_1 1276756.AUEX01000003_gene853 2.72e-140 419.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,4AA13@80864|Comamonadaceae 28216|Betaproteobacteria K RNA binding S1 domain protein tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_488905_1 72019.SARC_06569T0 2.03e-11 70.5 COG0218@1|root,KOG2486@2759|Eukaryota 2759|Eukaryota V GTP binding - - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_383754_1 398767.Glov_1575 8.26e-37 145.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_699386_1 794903.OPIT5_26740 2.3e-26 112.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 k59_414058_2 395495.Lcho_1709 1.08e-27 114.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KJUI@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_165722_1 981223.AIED01000019_gene608 2.31e-19 88.2 COG2988@1|root,COG2988@2|Bacteria,1MW1T@1224|Proteobacteria,1RQPG@1236|Gammaproteobacteria,3NK6H@468|Moraxellaceae 1236|Gammaproteobacteria E Belongs to the AspA AstE family. Succinylglutamate desuccinylase subfamily astE GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009017,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.96 ko:K05526 ko00330,ko01100,map00330,map01100 - R00411 RC00064,RC00090 ko00000,ko00001,ko01000 - - - AstE_AspA k59_1064006_1 296591.Bpro_3565 5.09e-101 305.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,4AA1V@80864|Comamonadaceae 28216|Betaproteobacteria S AI-2E family transporter perM - - - - - - - - - - - AI-2E_transport k59_947126_1 640081.Dsui_0626 4.91e-93 278.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,2KU8C@206389|Rhodocyclales 206389|Rhodocyclales E ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_845435_1 987059.RBXJA2T_18839 3.27e-06 49.3 COG1024@1|root,COG1024@2|Bacteria,1NYF6@1224|Proteobacteria,2VPXB@28216|Betaproteobacteria,1KMW1@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - - k59_623390_2 614083.AWQR01000009_gene621 5.37e-88 260.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,4ADFG@80864|Comamonadaceae 28216|Betaproteobacteria G PTS IIA-like nitrogen-regulatory protein PtsN ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_623390_3 1276756.AUEX01000005_gene2677 1.12e-201 561.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,4ABFX@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_623390_4 614083.AWQR01000009_gene619 1.63e-83 248.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,4ADIN@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_623390_5 397945.Aave_4554 1.48e-11 63.2 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,4ADZZ@80864|Comamonadaceae 28216|Betaproteobacteria J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_914607_1 1121373.KB903631_gene658 6.85e-77 240.0 COG0057@1|root,COG0057@2|Bacteria,4NEMF@976|Bacteroidetes,47KPU@768503|Cytophagia 976|Bacteroidetes G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_845440_1 395495.Lcho_3593 4.72e-204 572.0 COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,1KJ8V@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1126825_1 644801.Psest_4048 5.34e-128 379.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,1Z2PY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_414105_1 866536.Belba_2913 9.04e-89 285.0 COG1643@1|root,COG1643@2|Bacteria,4NFJ7@976|Bacteroidetes,47KRZ@768503|Cytophagia 976|Bacteroidetes L DEAD DEAH box helicase - - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_59049_1 870967.VIS19158_00355 1.62e-40 143.0 COG2834@1|root,COG2834@2|Bacteria,1RE9C@1224|Proteobacteria,1S9F3@1236|Gammaproteobacteria,1XSID@135623|Vibrionales 135623|Vibrionales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_59049_2 672.VV93_v1c30260 5.95e-13 68.9 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RZZ8@1236|Gammaproteobacteria,1XSWH@135623|Vibrionales 135623|Vibrionales M ABC-type transport system involved in lipoprotein release permease component VPA0017 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1064056_1 1343740.M271_41455 1.41e-20 89.7 COG1647@1|root,COG1647@2|Bacteria,2I54Y@201174|Actinobacteria 201174|Actinobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_914637_1 1005048.CFU_0973 9.14e-07 51.6 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,473TY@75682|Oxalobacteraceae 28216|Betaproteobacteria K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding - - - - - - - - - - - - GerE,Response_reg k59_1066712_1 83406.HDN1F_29560 1.52e-78 260.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_1128838_1 1144319.PMI16_03230 3.74e-47 152.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,477HU@75682|Oxalobacteraceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_386545_2 614083.AWQR01000022_gene86 2.64e-24 103.0 COG1070@1|root,COG1070@2|Bacteria,1MUHF@1224|Proteobacteria,2VNPB@28216|Betaproteobacteria,4AGJK@80864|Comamonadaceae 28216|Betaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain fucK - - - - - - - - - - - FGGY_N k59_624933_1 365046.Rta_29030 9.55e-19 79.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2VSCX@28216|Betaproteobacteria,4AEI1@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_624933_2 887062.HGR_00981 8.58e-47 159.0 COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2VJKY@28216|Betaproteobacteria,4AB5F@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM AAA ATPase central domain protein - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA k59_24559_1 1198452.Jab_2c17850 1.6e-107 323.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,4738Q@75682|Oxalobacteraceae 28216|Betaproteobacteria C Proton-conducting membrane transporter nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_881955_1 1120977.JHUX01000003_gene1125 3.24e-21 99.4 COG3756@1|root,COG3756@2|Bacteria,1N7P7@1224|Proteobacteria,1SDRK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_881955_2 1266925.JHVX01000002_gene824 4.87e-43 151.0 28NX5@1|root,2ZBUW@2|Bacteria,1R8Z1@1224|Proteobacteria,2VQ96@28216|Betaproteobacteria,373XM@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_881955_3 411901.BACCAC_01208 8.28e-21 86.3 29NSD@1|root,309QE@2|Bacteria,4PQ1Z@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_701516_1 159087.Daro_1307 6.4e-55 182.0 COG0732@1|root,COG0732@2|Bacteria,1PE04@1224|Proteobacteria,2WA1Q@28216|Betaproteobacteria,2KXIH@206389|Rhodocyclales 206389|Rhodocyclales L Type I restriction modification DNA specificity domain hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_96649_1 376686.Fjoh_3950 3.77e-20 97.4 COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia,2NSMW@237|Flavobacterium 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - CarboxypepD_reg,OmpA,PD40 k59_1097193_1 1198452.Jab_2c10430 1.79e-75 234.0 COG0834@1|root,COG0834@2|Bacteria,1RD01@1224|Proteobacteria,2VMAG@28216|Betaproteobacteria,478VK@75682|Oxalobacteraceae 28216|Betaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - - - - - - - - - - - k59_1128934_2 929703.KE386491_gene786 3.55e-36 127.0 COG4502@1|root,COG4502@2|Bacteria,4NQDT@976|Bacteroidetes,47QKD@768503|Cytophagia 976|Bacteroidetes S PFAM 5 nucleotidase deoxy - - - - - - - - - - - - NT5C k59_234104_1 1504672.669783041 2.05e-79 256.0 COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,4AAMN@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Orn Lys Arg decarboxylase major region adi - 4.1.1.19 ko:K01584 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N k59_234104_2 580332.Slit_2509 8.47e-22 93.6 28HIY@1|root,2Z7U8@2|Bacteria,1MY3K@1224|Proteobacteria,2VKE4@28216|Betaproteobacteria,44V51@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_167834_1 365046.Rta_17600 1.14e-120 373.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,4ABM3@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_625002_2 383407.XOC_2297 3.78e-31 125.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X982@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis protein - - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_1097216_1 1504672.669786636 2.45e-40 140.0 COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2VNEC@28216|Betaproteobacteria,4AAPB@80864|Comamonadaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component tupB - 3.6.3.55 ko:K05773,ko:K06857 ko02010,map02010 M00186 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_1097216_2 596154.Alide2_3596 3.95e-31 118.0 COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,4A9MK@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM regulatory protein, LysR - - - ko:K07219 - - - - ko00000 - - - HTH_1,PBP_like k59_561531_1 296591.Bpro_3165 4.93e-154 450.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,4A9JS@80864|Comamonadaceae 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_315497_1 1123248.KB893328_gene907 1.2e-44 164.0 COG3292@1|root,COG3292@2|Bacteria,4NE4U@976|Bacteroidetes,1IR5K@117747|Sphingobacteriia 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - - k59_701564_1 1454004.AW11_00525 3.49e-26 103.0 COG0596@1|root,COG0596@2|Bacteria,1QXP7@1224|Proteobacteria,2VPPV@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_701564_2 1121035.AUCH01000015_gene2547 7.53e-66 204.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,2KVUE@206389|Rhodocyclales 206389|Rhodocyclales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_737556_2 365044.Pnap_2731 3.37e-22 95.5 COG1802@1|root,COG1802@2|Bacteria,1NWSI@1224|Proteobacteria,2VJQW@28216|Betaproteobacteria,4A9JY@80864|Comamonadaceae 28216|Betaproteobacteria K Regulatory protein GntR HTH - - - ko:K11475 - - - - ko00000,ko03000 - - - FCD,GntR k59_789090_1 1276756.AUEX01000002_gene523 4.04e-26 107.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHEI@28216|Betaproteobacteria,4AC9Q@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_789090_2 159087.Daro_2057 4.57e-49 160.0 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2VRAN@28216|Betaproteobacteria,2KXE9@206389|Rhodocyclales 206389|Rhodocyclales S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_360744_1 358220.C380_11505 2.38e-57 186.0 COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,2WGBZ@28216|Betaproteobacteria,4ACMM@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the methyltransferase superfamily - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_504521_1 1000565.METUNv1_01947 5.22e-99 320.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales 206389|Rhodocyclales E glutamate synthase gls1 - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_3273_1 1000565.METUNv1_00623 1.3e-137 402.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,2KUYZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_289452_1 525256.HMPREF0091_10715 2.21e-65 212.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4CUYM@84998|Coriobacteriia 84998|Coriobacteriia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_39532_1 1000565.METUNv1_03713 1.96e-155 450.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,2KUH8@206389|Rhodocyclales 206389|Rhodocyclales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groEL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_145784_1 1000565.METUNv1_02950 6.78e-108 323.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KUV1@206389|Rhodocyclales 206389|Rhodocyclales S modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_360756_2 159087.Daro_1631 1.18e-51 181.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,2KUB6@206389|Rhodocyclales 206389|Rhodocyclales ET His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_3278_1 1000565.METUNv1_02106 5.66e-09 56.2 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KV4Z@206389|Rhodocyclales 206389|Rhodocyclales P Mg2 and Co2 transporter CorC - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_216895_1 365044.Pnap_0574 6.8e-113 336.0 COG4102@1|root,COG4102@2|Bacteria,1QVET@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_573857_7 401526.TcarDRAFT_1282 3.75e-57 183.0 COG2963@1|root,COG2963@2|Bacteria,1V6XW@1239|Firmicutes,4H8AS@909932|Negativicutes 909932|Negativicutes L transposase activity - - - - - - - - - - - - HTH_23 k59_573857_8 1283284.AZUK01000001_gene2659 7.66e-195 560.0 COG1783@1|root,COG4373@1|root,COG1783@2|Bacteria,COG4373@2|Bacteria,1R6J1@1224|Proteobacteria,1RS5V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phage Terminase large subunit - - - ko:K06909 - - - - ko00000 - - - - k59_647411_1 395495.Lcho_1250 3.72e-139 407.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,1KJNW@119065|unclassified Burkholderiales 28216|Betaproteobacteria S deoxyribodipyrimidine photolyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_433040_1 1000565.METUNv1_00354 9e-119 351.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,2KUCB@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_1002529_2 1000565.METUNv1_01388 2.81e-162 468.0 COG0827@1|root,COG0827@2|Bacteria,1QP3Z@1224|Proteobacteria,2VI9V@28216|Betaproteobacteria,2KVWP@206389|Rhodocyclales 206389|Rhodocyclales L Eco57I restriction-modification methylase - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I k59_1002529_3 1000565.METUNv1_01388 9.46e-05 44.7 COG0827@1|root,COG0827@2|Bacteria,1QP3Z@1224|Proteobacteria,2VI9V@28216|Betaproteobacteria,2KVWP@206389|Rhodocyclales 206389|Rhodocyclales L Eco57I restriction-modification methylase - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I k59_1109412_1 232346.JHQL01000002_gene794 2.2e-97 291.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1XI2H@135619|Oceanospirillales 135619|Oceanospirillales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_1075776_1 266264.Rmet_5206 4.52e-104 314.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1JZMS@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family amnC - 1.2.1.32,1.2.1.85 ko:K10217 ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220 M00038,M00569 R02762,R03889,R05353 RC00218,RC00254 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_824187_1 757424.Hsero_3057 3.16e-77 245.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,473J2@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome bd-type quinol oxidase, subunit 1 cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_1038913_1 1000565.METUNv1_03751 9.55e-70 227.0 2DBM3@1|root,2Z9WX@2|Bacteria,1R676@1224|Proteobacteria,2VPUB@28216|Betaproteobacteria,2KWS6@206389|Rhodocyclales 206389|Rhodocyclales S TIGRFAM PEP-CTERM system associated protein - - - - - - - - - - - - - k59_110207_1 1000565.METUNv1_02144 4.71e-169 480.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,2KUNP@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_647437_1 202952.BBLI01000054_gene3105 1.15e-16 82.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,3NIPH@468|Moraxellaceae 1236|Gammaproteobacteria S UPF0761 membrane protein rbn GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_647437_2 33898.JRHJ01000016_gene4113 5.13e-10 60.5 COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria 201174|Actinobacteria M Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_433069_1 1532557.JL37_10025 2.09e-39 140.0 COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,3T6I6@506|Alcaligenaceae 28216|Betaproteobacteria EM Belongs to the DapA family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_433069_2 266265.Bxe_B2770 1.49e-09 58.9 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,1K1HS@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein - - - ko:K06911 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_789136_1 1000565.METUNv1_01008 9.43e-20 88.2 COG4447@1|root,COG4447@2|Bacteria,1RCCJ@1224|Proteobacteria,2VJGM@28216|Betaproteobacteria,2KVJ7@206389|Rhodocyclales 206389|Rhodocyclales S Photosynthesis system II assembly factor YCF48 - - - - - - - - - - - - PSII_BNR k59_789136_2 1236959.BAMT01000014_gene2887 1.09e-05 47.8 COG2010@1|root,COG2010@2|Bacteria,1RHET@1224|Proteobacteria,2W3EV@28216|Betaproteobacteria,2KP1A@206350|Nitrosomonadales 206350|Nitrosomonadales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_930669_1 266265.Bxe_A3430 2.8e-34 123.0 COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria,2VUCP@28216|Betaproteobacteria,1K94M@119060|Burkholderiaceae 28216|Betaproteobacteria H Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_326054_1 1198452.Jab_2c28420 1.64e-112 330.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VPK7@28216|Betaproteobacteria,4726H@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaC - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_896175_1 1000565.METUNv1_01879 3.33e-60 197.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KURK@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_896175_2 159087.Daro_3140 7.77e-44 145.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,2KWAF@206389|Rhodocyclales 206389|Rhodocyclales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_289505_1 1000565.METUNv1_00896 5.16e-12 62.8 COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KWDI@206389|Rhodocyclales 206389|Rhodocyclales S ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_289505_2 1000565.METUNv1_00894 4.63e-99 288.0 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria,2KW90@206389|Rhodocyclales 206389|Rhodocyclales FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_289505_3 1000565.METUNv1_00893 9.29e-106 311.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria 28216|Betaproteobacteria C eight transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_681050_2 1000565.METUNv1_02828 6.28e-65 204.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KWGP@206389|Rhodocyclales 206389|Rhodocyclales S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_717668_1 1000565.METUNv1_01951 1.73e-52 180.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KVCK@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_789161_1 714943.Mucpa_1600 8.92e-30 111.0 COG4232@1|root,COG4232@2|Bacteria,4NT86@976|Bacteroidetes,1ITHG@117747|Sphingobacteriia 976|Bacteroidetes CO PFAM thioredoxin domain - - - - - - - - - - - - Thioredoxin k59_789161_2 762903.Pedsa_2689 8.57e-15 72.0 COG0526@1|root,COG0526@2|Bacteria,4NM4Y@976|Bacteroidetes,1ITRD@117747|Sphingobacteriia 976|Bacteroidetes CO Thioredoxin - - - - - - - - - - - - Thioredoxin_9 k59_216918_1 1000565.METUNv1_02626 1.54e-81 253.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2VIH0@28216|Betaproteobacteria,2KVJ0@206389|Rhodocyclales 206389|Rhodocyclales N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_216918_2 1500890.JQNL01000001_gene2305 3.98e-68 243.0 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,1T1MJ@1236|Gammaproteobacteria,1X4X8@135614|Xanthomonadales 135614|Xanthomonadales U Autotransporter beta-domain yapH - - - - - - - - - - - ESPR,PATR k59_433120_2 1341679.P253_00258 6.44e-17 80.5 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - GerE k59_504634_1 929703.KE386491_gene3368 2.61e-94 290.0 COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,47J9Q@768503|Cytophagia 976|Bacteroidetes EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_896204_1 1000565.METUNv1_03253 5.04e-75 239.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KUSQ@206389|Rhodocyclales 206389|Rhodocyclales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_74248_1 543728.Vapar_1802 5.59e-100 295.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,4AA9M@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the BI1 family yccA - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_896205_1 1000565.METUNv1_00632 1.71e-61 191.0 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,2VWEY@28216|Betaproteobacteria,2KXCZ@206389|Rhodocyclales 206389|Rhodocyclales NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 k59_896205_2 1000565.METUNv1_00631 3.33e-60 191.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,2KUHJ@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_253726_1 925409.KI911562_gene2849 2.94e-43 145.0 COG1959@1|root,COG1959@2|Bacteria,4NY03@976|Bacteroidetes,1IXYJ@117747|Sphingobacteriia 976|Bacteroidetes K transcriptional regulator - - - - - - - - - - - - Rrf2 k59_647519_1 760192.Halhy_6518 6.25e-114 347.0 COG1506@1|root,COG1506@2|Bacteria,4NE2Q@976|Bacteroidetes,1IR4V@117747|Sphingobacteriia 976|Bacteroidetes E peptidase S9B dipeptidylpeptidase IV domain protein - - - - - - - - - - - - DPPIV_N,Peptidase_S9 k59_1075866_1 365044.Pnap_0605 1.3e-102 302.0 COG1024@1|root,COG1024@2|Bacteria,1MWYZ@1224|Proteobacteria,2VJYU@28216|Betaproteobacteria,4AB6X@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.155 ko:K20036 ko00920,map00920 - R10936 RC00004,RC03306,RC03307 ko00000,ko00001,ko01000 - - - ECH_1 k59_609167_1 1000565.METUNv1_00648 1.28e-89 292.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,2KVJB@206389|Rhodocyclales 206389|Rhodocyclales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_504657_1 748247.AZKH_3168 7.72e-143 421.0 COG0145@1|root,COG0145@2|Bacteria,1R3RA@1224|Proteobacteria,2VZPU@28216|Betaproteobacteria,2KYJI@206389|Rhodocyclales 206389|Rhodocyclales J Hydantoinase/oxoprolinase N-terminal region - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_326122_1 614083.AWQR01000014_gene2435 1.56e-18 84.7 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,4A9Z5@80864|Comamonadaceae 28216|Betaproteobacteria H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_326122_2 614083.AWQR01000014_gene2434 1.56e-68 214.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,4AAAK@80864|Comamonadaceae 28216|Betaproteobacteria E HAD-superfamily hydrolase, subfamily IB, PSPase-like - - - - - - - - - - - - HAD k59_1038986_1 45157.CMH103CT 3.25e-17 81.3 COG1028@1|root,KOG0725@2759|Eukaryota 2759|Eukaryota IQ oxidation-reduction process - - - - - - - - - - - - adh_short k59_647533_1 483219.LILAB_30100 6.37e-54 191.0 COG0001@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,43E1T@68525|delta/epsilon subdivisions,2X7HJ@28221|Deltaproteobacteria,2YWQV@29|Myxococcales 28221|Deltaproteobacteria HQ Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt k59_434958_2 358220.C380_01785 2.27e-24 99.8 COG3618@1|root,COG3618@2|Bacteria,1QWWJ@1224|Proteobacteria,2VMAE@28216|Betaproteobacteria,4AAG5@80864|Comamonadaceae 28216|Betaproteobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_825447_1 1000565.METUNv1_01666 7.37e-95 296.0 COG2982@1|root,COG2982@2|Bacteria,1RD61@1224|Proteobacteria,2VS09@28216|Betaproteobacteria,2KWG8@206389|Rhodocyclales 206389|Rhodocyclales M AsmA-like C-terminal region - - - - - - - - - - - - AsmA_2 k59_718507_1 1000565.METUNv1_03461 4.85e-110 327.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KVWV@206389|Rhodocyclales 206389|Rhodocyclales S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_649293_1 236097.ADG881_1670 6.59e-99 303.0 28JZ4@1|root,2Z9P9@2|Bacteria,1R5SB@1224|Proteobacteria,1S09G@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_217515_1 1000565.METUNv1_01321 0.0 987.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,2WHG0@28216|Betaproteobacteria 28216|Betaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3 k59_111156_1 1000565.METUNv1_02329 1.32e-148 430.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KU72@206389|Rhodocyclales 206389|Rhodocyclales P protein involved in response to NO - - - ko:K07234 - - - - ko00000 - - - NnrS k59_397972_1 323259.Mhun_0174 3.69e-54 185.0 COG1892@1|root,arCOG04435@2157|Archaea,2XUGP@28890|Euryarchaeota,2NAY9@224756|Methanomicrobia 224756|Methanomicrobia G Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle ppcA - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase_2 k59_931562_1 1189612.A33Q_4151 6.35e-32 125.0 COG5002@1|root,COG5002@2|Bacteria,4PKBV@976|Bacteroidetes,47MII@768503|Cytophagia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_931562_2 869213.JCM21142_41379 7.87e-12 64.3 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,47KCE@768503|Cytophagia 976|Bacteroidetes T PFAM response regulator receiver rprY - - - - - - - - - - - Response_reg,Trans_reg_C k59_753354_1 1538295.JY96_01935 1.92e-41 147.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,1KKE8@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Major Facilitator Superfamily narK - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_649342_1 1177181.T9A_02504 1.48e-10 67.4 COG3203@1|root,COG3203@2|Bacteria,1Q1XX@1224|Proteobacteria,1RPIH@1236|Gammaproteobacteria,1XJZA@135619|Oceanospirillales 135619|Oceanospirillales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_506410_1 1000565.METUNv1_00993 5.73e-23 104.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_649345_1 1163409.UUA_04528 1.34e-32 124.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales 135614|Xanthomonadales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_649345_2 1283300.ATXB01000001_gene2456 1.57e-21 85.5 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,1SCFF@1236|Gammaproteobacteria,1XFSG@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_649345_3 519989.ECTPHS_10721 6.52e-23 94.4 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1WWTZ@135613|Chromatiales 135613|Chromatiales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_574753_1 1163409.UUA_05877 1.03e-15 77.4 COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1X773@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0149 family - - - ko:K09895 - - - - ko00000 - - - UPF0149 k59_374434_1 614083.AWQR01000014_gene2490 6.48e-91 293.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_345788_1 1000565.METUNv1_02466 4.16e-120 348.0 COG0625@1|root,COG0625@2|Bacteria,1MX33@1224|Proteobacteria,2VMW8@28216|Betaproteobacteria 28216|Betaproteobacteria O Outer mitochondrial membrane transport complex protein - - - - - - - - - - - - GST_C_6,GST_N_4 k59_345788_2 1000565.METUNv1_02465 1.38e-39 132.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,2KWXB@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_1052517_2 1117958.PE143B_0129740 5.67e-30 110.0 2CT6R@1|root,32SSQ@2|Bacteria,1N4HA@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_617868_1 1095769.CAHF01000006_gene1758 8.32e-18 83.6 COG5380@1|root,COG5380@2|Bacteria,1MZT4@1224|Proteobacteria,2VVEZ@28216|Betaproteobacteria,4744C@75682|Oxalobacteraceae 28216|Betaproteobacteria O Proteobacterial lipase chaperone protein lifO - - - - - - - - - - - Lipase_chap k59_617868_2 338969.Rfer_0375 1.93e-49 159.0 29G0K@1|root,302YD@2|Bacteria,1RG5E@1224|Proteobacteria,2VRBH@28216|Betaproteobacteria,4AE9C@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1015193_1 196367.JNFG01000033_gene7429 3.63e-38 134.0 COG1395@1|root,COG1395@2|Bacteria,1RFQP@1224|Proteobacteria,2WGHD@28216|Betaproteobacteria,1K9TR@119060|Burkholderiaceae 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_1015193_2 381666.PHG182 1.08e-69 219.0 2BNRQ@1|root,32HF7@2|Bacteria,1PA1V@1224|Proteobacteria,2VQ4V@28216|Betaproteobacteria,1K7Y2@119060|Burkholderiaceae 28216|Betaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_1052525_1 1122951.ATUE01000006_gene1305 5.74e-158 465.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,3NJC4@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_453588_1 265072.Mfla_2424 1e-71 219.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KMPH@206350|Nitrosomonadales 206350|Nitrosomonadales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_550220_1 1000565.METUNv1_01307 6.44e-105 321.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KV7D@206389|Rhodocyclales 206389|Rhodocyclales NT Cache_2 - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 k59_692142_1 946483.Cenrod_0845 2.44e-19 87.8 COG0834@1|root,COG0834@2|Bacteria,1N0VS@1224|Proteobacteria,2VXE3@28216|Betaproteobacteria 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_692142_2 948106.AWZT01000039_gene1168 6.74e-24 97.4 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VIBS@28216|Betaproteobacteria,1K3GU@119060|Burkholderiaceae 28216|Betaproteobacteria P Reversible hydration of carbon dioxide can - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Pro_CA k59_524647_1 335283.Neut_2415 2.91e-28 110.0 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,2VH5G@28216|Betaproteobacteria,372IE@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM filamentation induced by cAMP protein Fic - - - - - - - - - - - - Fic k59_524647_2 1000565.METUNv1_00222 1.05e-50 161.0 COG3668@1|root,COG3668@2|Bacteria,1N9C2@1224|Proteobacteria,2VWK0@28216|Betaproteobacteria,2KXN9@206389|Rhodocyclales 206389|Rhodocyclales S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_977521_1 1121035.AUCH01000006_gene763 3.26e-88 278.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,2KVMW@206389|Rhodocyclales 206389|Rhodocyclales K RNB - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_762613_1 1198452.Jab_1c00790 9.66e-82 261.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,2WBUF@28216|Betaproteobacteria,476GX@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_86605_1 1000565.METUNv1_03388 4.9e-58 191.0 COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,2VHD9@28216|Betaproteobacteria,2KUNH@206389|Rhodocyclales 206389|Rhodocyclales U glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_86605_2 1000565.METUNv1_03389 9.6e-60 193.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,2KUJJ@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_374474_1 1175306.GWL_00030 3.92e-16 80.1 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,472ID@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1052564_1 1157708.KB907450_gene5386 1.56e-124 364.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,4AABM@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_550250_1 883.DvMF_0793 1.33e-13 77.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42NNT@68525|delta/epsilon subdivisions,2WJDP@28221|Deltaproteobacteria,2M8A1@213115|Desulfovibrionales 28221|Deltaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,MCPsignal k59_480294_1 614083.AWQR01000031_gene2570 1.28e-111 331.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2VHR0@28216|Betaproteobacteria,4AAU7@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_668076_1 1000565.METUNv1_03740 4.21e-60 200.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,2VKXR@28216|Betaproteobacteria,2KVG6@206389|Rhodocyclales 206389|Rhodocyclales T Sh3 type 3 domain protein - - - - - - - - - - - - - k59_158473_2 1384054.N790_01105 4.15e-65 216.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1X8HM@135614|Xanthomonadales 135614|Xanthomonadales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - CHASE2,Guanylate_cyc k59_1052600_1 1454004.AW11_00539 9.66e-94 287.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria 28216|Betaproteobacteria S Amidohydrolase uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_762638_1 614083.AWQR01000022_gene96 3.05e-11 62.8 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VNEZ@28216|Betaproteobacteria,4AJ3N@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase yeiT - 1.3.1.1 ko:K17722 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Pyr_redox_2 k59_762638_2 614083.AWQR01000022_gene97 2.65e-102 306.0 COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,1MXER@1224|Proteobacteria,2VK6N@28216|Betaproteobacteria,4AD1V@80864|Comamonadaceae 28216|Betaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein yeiA - 1.3.1.1,1.3.1.14 ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,Fer4_21,Fer4_6 k59_617915_1 1123248.KB893359_gene2097 3.86e-94 298.0 COG1452@1|root,COG1452@2|Bacteria,4PNMH@976|Bacteroidetes,1J0ZH@117747|Sphingobacteriia 976|Bacteroidetes M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_453666_1 595537.Varpa_4842 9.76e-153 434.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,4A9NG@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_374514_1 640081.Dsui_2828 3.98e-137 396.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2VTE7@28216|Betaproteobacteria,2KZT0@206389|Rhodocyclales 28216|Betaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_617944_1 1008459.TASI_0431 4.65e-116 348.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VQF3@28216|Betaproteobacteria,3T4Y5@506|Alcaligenaceae 28216|Betaproteobacteria KL helicase superfamily c-terminal domain - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_940993_1 228410.NE1531 1.29e-137 418.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VMX1@28216|Betaproteobacteria,374MI@32003|Nitrosomonadales 28216|Betaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_583766_1 1121396.KB893079_gene857 9.87e-08 60.8 COG4191@1|root,COG4564@1|root,COG4191@2|Bacteria,COG4564@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MPJ3@213118|Desulfobacterales 28221|Deltaproteobacteria T PAS fold - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_837103_1 1198452.Jab_2c30820 3.48e-95 307.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,47913@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_941006_1 1443665.JACA01000013_gene4145 5.26e-14 77.4 COG4585@1|root,COG4585@2|Bacteria,4NI8Z@976|Bacteroidetes,1HZHS@117743|Flavobacteriia,2YJ6J@290174|Aquimarina 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,TPR_12,TPR_8 k59_480389_1 1419583.V466_28995 5.43e-07 56.6 COG5185@1|root,COG5281@1|root,COG5185@2|Bacteria,COG5281@2|Bacteria,1QUCD@1224|Proteobacteria,1T1T2@1236|Gammaproteobacteria,1YRAU@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria D Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Phage_HK97_TLTM,TMP_2,Tape_meas_lam_C k59_977632_1 1000565.METUNv1_02953 3.45e-60 190.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,2KUYM@206389|Rhodocyclales 206389|Rhodocyclales M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_977632_2 1000565.METUNv1_02952 1.11e-85 256.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2VH28@28216|Betaproteobacteria,2KUQ0@206389|Rhodocyclales 206389|Rhodocyclales H Molybdenum cofactor biosynthesis protein mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_226222_1 582744.Msip34_2706 4.29e-45 166.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KKQK@206350|Nitrosomonadales 206350|Nitrosomonadales NT PFAM chemotaxis sensory transducer - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_407556_1 1238190.AMQY01000021_gene1545 8.56e-14 72.4 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,1RY6S@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_908159_1 929713.NIASO_19830 3.2e-65 218.0 COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1IQ72@117747|Sphingobacteriia 976|Bacteroidetes O COG1331 Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_872116_1 1499686.BN1079_02586 1.08e-47 167.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_51803_1 338969.Rfer_1890 1.23e-106 313.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2WEJG@28216|Betaproteobacteria,4AJ3P@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_762723_1 365044.Pnap_3153 6.17e-104 321.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4ACRA@80864|Comamonadaceae 28216|Betaproteobacteria NU General secretory system II, protein E domain protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_266692_1 1236508.BAKF01000009_gene973 1.22e-27 112.0 COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,2FNFK@200643|Bacteroidia 976|Bacteroidetes L Belongs to the 'phage' integrase family xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_837155_1 62928.azo1419 1.74e-30 117.0 COG3568@1|root,COG3568@2|Bacteria,1R8DZ@1224|Proteobacteria,2WGET@28216|Betaproteobacteria,2M04Q@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_837155_2 1121035.AUCH01000005_gene138 8.18e-41 142.0 COG1024@1|root,COG1024@2|Bacteria,1R3SQ@1224|Proteobacteria,2VJRJ@28216|Betaproteobacteria,2KWFF@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl-CoA hydratase/isomerase - - 4.1.1.41 ko:K11264 ko00640,map00640 - R00923 RC00097 ko00000,ko00001,ko01000 - - - ECH_1 k59_583809_1 390235.PputW619_3139 1.38e-91 281.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1YY64@136845|Pseudomonas putida group 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - 3.5.4.28,3.5.4.3,3.5.4.31 ko:K01487,ko:K12960 ko00230,ko00270,ko01100,map00230,map00270,map01100 - R01676,R09660 RC00204,RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_158598_1 1232410.KI421413_gene589 7.69e-39 147.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43S8H@69541|Desulfuromonadales 28221|Deltaproteobacteria T sensor diguanylate cyclase phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,dCache_1 k59_837165_1 207954.MED92_00475 7e-72 234.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_762732_1 375286.mma_2982 4.25e-33 130.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,2VICU@28216|Betaproteobacteria,473E9@75682|Oxalobacteraceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain pilS - 2.7.13.3 ko:K02668,ko:K10125 ko02020,map02020 M00501,M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_266710_1 640081.Dsui_0236 9.33e-90 276.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,2KVFZ@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_51836_1 1452718.JBOY01000040_gene1935 1.23e-101 311.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1120223_1 1163617.SCD_n02891 2.02e-80 253.0 COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_226268_1 1198452.Jab_1c11780 1.69e-87 286.0 COG0308@1|root,COG0308@2|Bacteria,1PTWJ@1224|Proteobacteria,2WAGH@28216|Betaproteobacteria,475KW@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase family M1 domain - - - - - - - - - - - - ABC2_membrane_4,Peptidase_M1 k59_837186_1 1278073.MYSTI_02092 9.46e-42 156.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_407595_1 1000565.METUNv1_02574 2.93e-83 261.0 arCOG04928@1|root,2Z880@2|Bacteria,1NBNZ@1224|Proteobacteria,2VNGI@28216|Betaproteobacteria 28216|Betaproteobacteria S CRISPR-associated protein Cse1 (CRISPR_cse1) - - - ko:K19123 - - - - ko00000,ko02048 - - - CRISPR_Cse1 k59_407595_2 1000565.METUNv1_02573 3.06e-109 315.0 2EMUR@1|root,33FH1@2|Bacteria,1NGE1@1224|Proteobacteria,2VY86@28216|Betaproteobacteria 28216|Betaproteobacteria S CRISPR-associated protein Cse2 (CRISPR_cse2) - - - ko:K19046 - - - - ko00000,ko02048 - - - CRISPR_Cse2 k59_407595_3 1000565.METUNv1_02572 1.1e-20 89.0 COG1857@1|root,COG1857@2|Bacteria,1MVNH@1224|Proteobacteria,2VP5P@28216|Betaproteobacteria,2KYSV@206389|Rhodocyclales 206389|Rhodocyclales L CT1975-like protein - - - ko:K19124 - - - - ko00000,ko02048 - - - Cas_CT1975 k59_346122_1 1268237.G114_16415 4.13e-33 122.0 COG0529@1|root,COG0529@2|Bacteria,1N2Z8@1224|Proteobacteria,1SR4U@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Adenylylsulphate kinase - - - - - - - - - - - - APS_kinase k59_374652_1 522306.CAP2UW1_0283 9.81e-78 251.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1KPQI@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K Protein involved in ribonuclease activity and hydrolase activity rnb - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_86786_1 296591.Bpro_1671 5.97e-225 624.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2VHDV@28216|Betaproteobacteria,4AA6Z@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_203252_1 640081.Dsui_0846 2.55e-97 300.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,2KUAA@206389|Rhodocyclales 206389|Rhodocyclales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_524961_1 1000565.METUNv1_03283 9.71e-45 158.0 COG0664@1|root,COG2172@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,2KX5A@206389|Rhodocyclales 206389|Rhodocyclales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_524961_2 1000565.METUNv1_03284 7.03e-64 196.0 COG1366@1|root,COG1366@2|Bacteria,1NECY@1224|Proteobacteria 1224|Proteobacteria T STAS domain - - - - - - - - - - - - STAS,STAS_2 k59_524961_3 1000565.METUNv1_03285 4.45e-61 192.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,2KVP4@206389|Rhodocyclales 206389|Rhodocyclales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_1054926_1 1392540.P256_01765 3.41e-15 68.9 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,3NPA8@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1054926_2 1122951.ATUE01000011_gene498 3.49e-41 137.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,3NNW9@468|Moraxellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1054926_3 1122244.AUGF01000010_gene370 4.4e-07 48.5 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,3NN4P@468|Moraxellaceae 1236|Gammaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1016696_1 1000565.METUNv1_00665 8.26e-172 493.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,2KVAB@206389|Rhodocyclales 206389|Rhodocyclales H squalene-associated FAD-dependent desaturase - - - - - - - - - - - - Amino_oxidase k59_1054933_1 358220.C380_14805 1.5e-24 99.4 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VIZP@28216|Betaproteobacteria,4A9RC@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1054933_2 243231.GSU2401 2.95e-21 96.7 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WJ5T@28221|Deltaproteobacteria,43SYP@69541|Desulfuromonadales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1 k59_53256_1 1122951.ATUE01000007_gene738 2.75e-86 271.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,1RQD3@1236|Gammaproteobacteria,3NKGQ@468|Moraxellaceae 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182,ko:K13776 ko00281,map00281 - R08088 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_268268_2 640081.Dsui_0805 1.51e-96 301.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,2KVAV@206389|Rhodocyclales 206389|Rhodocyclales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_693784_1 1000565.METUNv1_02232 3.97e-35 130.0 COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,2VQR3@28216|Betaproteobacteria,2KWDC@206389|Rhodocyclales 206389|Rhodocyclales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_693784_2 1000565.METUNv1_02231 1.44e-32 125.0 COG1538@1|root,COG1538@2|Bacteria,1PKUI@1224|Proteobacteria,2VMC6@28216|Betaproteobacteria,2KX9S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_16878_1 1000565.METUNv1_02532 1.22e-42 142.0 COG2916@1|root,COG2916@2|Bacteria,1N7YA@1224|Proteobacteria,2VW5J@28216|Betaproteobacteria,2KZ74@206389|Rhodocyclales 206389|Rhodocyclales K H-NS histone family - - - ko:K03746 - - - - ko00000,ko03036,ko03400 - - - Histone_HNS k59_16878_2 477184.KYC_27157 3.45e-114 345.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,3T23H@506|Alcaligenaceae 28216|Betaproteobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_838598_1 666681.M301_1418 1.25e-40 145.0 COG0404@1|root,COG0404@2|Bacteria,1N2I3@1224|Proteobacteria,2VVMU@28216|Betaproteobacteria,2KMXD@206350|Nitrosomonadales 206350|Nitrosomonadales E Sarcosine oxidase, gamma subunit family - - 1.5.3.1 ko:K00305 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxG k59_160084_1 1122951.ATUE01000008_gene106 8.69e-11 62.8 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,3NIWR@468|Moraxellaceae 1236|Gammaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037 GcpE k59_160084_2 694569.D7S_01887 7.29e-47 162.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1Y7S7@135625|Pasteurellales 135625|Pasteurellales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_670533_1 640081.Dsui_1069 1.69e-63 203.0 COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,2VQSF@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_670533_2 1304883.KI912532_gene2344 5.61e-16 75.1 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,2KYKN@206389|Rhodocyclales 206389|Rhodocyclales T Transcriptional regulatory protein, C terminal - - - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_31036_1 1122951.ATUE01000005_gene1873 3.58e-151 428.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,3NIUS@468|Moraxellaceae 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iYL1228.KPN_02481 His_biosynth k59_597549_1 1000565.METUNv1_01021 1.91e-95 291.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW0@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DEAD box helicase family rhlE1 - - - - - - - - - - - DEAD,Helicase_C k59_776807_1 887062.HGR_04903 1.84e-85 258.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,4AC8J@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the pirin family yhhW_2 - - ko:K06911 - - - - ko00000 - - - Pirin k59_138290_1 1173025.GEI7407_2986 3.1e-49 178.0 COG2114@1|root,COG2202@1|root,COG3605@1|root,COG3850@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG3605@2|Bacteria,COG3850@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,PAS_9,Response_reg k59_1101787_1 1299327.I546_3078 5.77e-60 201.0 COG1816@1|root,COG1816@2|Bacteria,2I8DI@201174|Actinobacteria 201174|Actinobacteria F Adenosine/AMP deaminase - - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_138301_1 1415779.JOMH01000001_gene2517 1.31e-58 200.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,1RNBP@1236|Gammaproteobacteria,1X8PU@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_597567_1 118797.XP_007468251.1 1.56e-103 335.0 COG0085@1|root,KOG0214@2759|Eukaryota 2759|Eukaryota K DNA-directed 5'-3' RNA polymerase activity rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_31060_1 411684.HPDFL43_01515 3.12e-106 311.0 COG1028@1|root,COG1028@2|Bacteria,1Q3GM@1224|Proteobacteria,2UCIW@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_31060_2 240016.ABIZ01000001_gene246 2.24e-14 72.8 COG0673@1|root,COG0673@2|Bacteria,46U48@74201|Verrucomicrobia 74201|Verrucomicrobia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_993182_1 1223521.BBJX01000009_gene1081 2.36e-07 53.9 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,4AJXC@80864|Comamonadaceae 28216|Betaproteobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1033142_1 1397528.Q671_14065 8.14e-90 271.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XIDG@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_597589_1 614083.AWQR01000058_gene1507 9.32e-106 337.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,4A9NT@80864|Comamonadaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_104166_1 1502770.JQMG01000001_gene2375 3.5e-40 140.0 2DKYH@1|root,30WKQ@2|Bacteria,1RCXC@1224|Proteobacteria,2VR6P@28216|Betaproteobacteria,2KN4S@206350|Nitrosomonadales 206350|Nitrosomonadales S TIGRFAM EpsI family protein - - - - - - - - - - - - DUF3485 k59_31079_1 62928.azo2330 4.62e-27 107.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,2KXU0@206389|Rhodocyclales 206389|Rhodocyclales U . ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane. PFam MotA TolQ ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_31079_2 62928.azo2329 1.77e-32 119.0 COG0810@1|root,COG0810@2|Bacteria,1RJRA@1224|Proteobacteria,2VTFA@28216|Betaproteobacteria,2KYPW@206389|Rhodocyclales 206389|Rhodocyclales U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1135970_2 748247.AZKH_1376 3.45e-37 132.0 COG2135@1|root,COG2135@2|Bacteria,1RJ1S@1224|Proteobacteria,2WFH7@28216|Betaproteobacteria,2KXD8@206389|Rhodocyclales 206389|Rhodocyclales E SOS response associated peptidase (SRAP) - - - - - - - - - - - - SRAP k59_175378_1 640081.Dsui_2221 3.51e-26 105.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,2KUMJ@206389|Rhodocyclales 206389|Rhodocyclales S AFG1-like ATPase afg - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_993217_1 1509405.GV67_19500 3.42e-51 171.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2UBBW@28211|Alphaproteobacteria,4BDYT@82115|Rhizobiaceae 28211|Alphaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH2 - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_67450_1 640081.Dsui_0393 1.19e-68 223.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,2KURY@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_954520_1 557598.LHK_01554 9.25e-21 96.3 COG0503@1|root,COG0503@2|Bacteria 2|Bacteria F purine ribonucleoside salvage apt - 2.4.2.22,2.4.2.7 ko:K00759,ko:K03816 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R00190,R01229,R02142,R04378 RC00063,RC00122 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_104228_1 1123504.JQKD01000064_gene2455 9.36e-91 279.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,4ABC3@80864|Comamonadaceae 28216|Betaproteobacteria S peptidase U62, modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_597649_1 393595.ABO_1388 7.51e-46 158.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1XJRF@135619|Oceanospirillales 135619|Oceanospirillales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_597649_2 466088.CL42_13155 1.76e-47 162.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,3NIUW@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_422315_1 4565.EPlTAEP00000010100 3.48e-31 123.0 COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,3KM7Q@4447|Liliopsida,3IE0D@38820|Poales 35493|Streptophyta C Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone - - 1.6.5.3 ko:K03883 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - NADH5_C,Proton_antipo_M,Proton_antipo_N k59_422315_2 1528098.NOVO_08120 9.4e-31 112.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,47FFJ@766|Rickettsiales 766|Rickettsiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_70029_1 1000565.METUNv1_03542 8.5e-10 58.2 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,2KUBD@206389|Rhodocyclales 206389|Rhodocyclales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_70029_2 1000565.METUNv1_03541 1.1e-49 158.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,2KWVF@206389|Rhodocyclales 206389|Rhodocyclales G Phosphotransferase System ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_70029_3 1000565.METUNv1_03540 1.91e-47 154.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KWTC@206389|Rhodocyclales 206389|Rhodocyclales G Phosphotransferase system, mannose fructose-specific component IIA ptsL - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_106828_1 1005048.CFU_0249 3.87e-82 264.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VMUG@28216|Betaproteobacteria,472D6@75682|Oxalobacteraceae 28216|Betaproteobacteria M C-terminal domain of tail specific protease (DUF3340) prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_710552_1 987059.RBXJA2T_07913 8.44e-30 117.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,1KJ7X@119065|unclassified Burkholderiales 28216|Betaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_710552_2 1000565.METUNv1_01431 1.52e-19 81.6 COG1918@1|root,COG1918@2|Bacteria 2|Bacteria P iron ion homeostasis feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_243007_2 870187.Thini_3264 6.14e-15 77.4 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,45ZYR@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_779664_1 946077.W5A_05958 4.57e-115 343.0 COG3844@1|root,COG3844@2|Bacteria,4NECS@976|Bacteroidetes,1HWY8@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_33677_1 1304883.KI912532_gene1629 8.26e-52 171.0 COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,2KW96@206389|Rhodocyclales 206389|Rhodocyclales S Phasin protein - - - - - - - - - - - - Phasin_2 k59_106842_1 1123248.KB893319_gene3958 3.34e-83 251.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1IQHJ@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_178398_2 1122951.ATUE01000006_gene1231 1.36e-58 199.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,3NJXI@468|Moraxellaceae 1236|Gammaproteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009436,GO:0009987,GO:0015980,GO:0016054,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iJN746.PP_0356,iWFL_1372.ECW_m3242 Malate_synthase k59_106847_1 987059.RBXJA2T_00809 2.4e-47 160.0 COG0346@1|root,COG0454@1|root,COG0346@2|Bacteria,COG0456@2|Bacteria,1RI45@1224|Proteobacteria,2WE8E@28216|Betaproteobacteria 28216|Betaproteobacteria EK Glyoxalase-like domain - - - - - - - - - - - - Acetyltransf_1,Glyoxalase k59_106858_1 743299.Acife_0838 1.03e-60 208.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,2NCCX@225057|Acidithiobacillales 225057|Acidithiobacillales L EcoEI R protein C-terminal - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,Helicase_C,ResIII k59_106858_2 1454004.AW11_02218 1.37e-10 60.5 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,1KQJS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Urease alpha-subunit, N-terminal domain ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_1138841_1 688245.CtCNB1_3063 4.65e-38 131.0 COG5528@1|root,COG5528@2|Bacteria,1RDUE@1224|Proteobacteria,2VRK8@28216|Betaproteobacteria,4AE7C@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted integral membrane protein (DUF2269) - - - - - - - - - - - - DUF2269 k59_1138841_2 1385515.N791_00210 6.25e-14 72.8 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RSKV@1236|Gammaproteobacteria,1X40S@135614|Xanthomonadales 135614|Xanthomonadales GM NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_600189_1 1396141.BATP01000001_gene5347 6.26e-07 50.8 COG2211@1|root,COG2211@2|Bacteria,46U6G@74201|Verrucomicrobia,2IV97@203494|Verrucomicrobiae 203494|Verrucomicrobiae G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_600189_2 471870.BACINT_04211 1.55e-50 179.0 COG1554@1|root,COG2382@1|root,COG1554@2|Bacteria,COG2382@2|Bacteria,4NEWW@976|Bacteroidetes,2FMF9@200643|Bacteroidia,4AMRU@815|Bacteroidaceae 976|Bacteroidetes G COG NOG04001 non supervised orthologous group - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2,SASA k59_141158_1 1089547.KB913013_gene1164 5.86e-88 285.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,47M7B@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_710608_2 614083.AWQR01000002_gene2983 6.97e-112 331.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VK9D@28216|Betaproteobacteria,4A9VN@80864|Comamonadaceae 28216|Betaproteobacteria E peptidase dimerisation domain protein - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1104167_1 1221522.B723_11040 3.81e-102 326.0 COG1196@1|root,COG1196@2|Bacteria,1R0Q9@1224|Proteobacteria,1T4NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_710611_1 479433.Caci_2842 4.75e-06 52.0 2F1HE@1|root,33UHX@2|Bacteria,2IH41@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_141169_1 1353529.M899_2497 1.46e-87 282.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2MSV5@213481|Bdellovibrionales,2WIZ2@28221|Deltaproteobacteria 213481|Bdellovibrionales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_996005_1 159087.Daro_1702 9.3e-105 312.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,2KU6M@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the radical SAM superfamily. PqqE family pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_14,Radical_SAM,SPASM k59_570896_1 998088.B565_0651 1.71e-42 155.0 COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,1NC9X@1224|Proteobacteria,1T1YW@1236|Gammaproteobacteria,1Y6MT@135624|Aeromonadales 135624|Aeromonadales T Domain of unknown function (DUF3369) - - - - - - - - - - - - DUF3369,HD,Response_reg k59_141185_1 1229205.BUPH_05999 6.75e-41 145.0 COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,2VQ7Q@28216|Betaproteobacteria,1KGNS@119060|Burkholderiaceae 28216|Betaproteobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_600212_1 1266925.JHVX01000002_gene767 3.47e-19 88.6 COG1073@1|root,COG1073@2|Bacteria,1RCY0@1224|Proteobacteria,2VR4Z@28216|Betaproteobacteria,372N7@32003|Nitrosomonadales 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4,Peptidase_S9 k59_600212_2 983917.RGE_21380 2.66e-39 134.0 COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VT4U@28216|Betaproteobacteria 28216|Betaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_106897_1 1000565.METUNv1_00868 6.88e-51 174.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,2VH5K@28216|Betaproteobacteria,2KV8U@206389|Rhodocyclales 206389|Rhodocyclales KLT Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090 - - - - ko00000,ko01000 - - - PP2C_2,Pkinase k59_106897_2 1000565.METUNv1_00869 1.29e-50 171.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,2KUW4@206389|Rhodocyclales 206389|Rhodocyclales P MFS/sugar transport protein narK - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_106898_1 1121904.ARBP01000021_gene3581 0.000136 50.8 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47Y22@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_1138886_1 485917.Phep_0633 6.31e-94 292.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,1IPCI@117747|Sphingobacteriia 976|Bacteroidetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_924927_1 925409.KI911562_gene928 1.58e-97 306.0 COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,1IRB5@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_996057_1 497964.CfE428DRAFT_1067 8.08e-51 177.0 COG2319@1|root,COG2319@2|Bacteria 2|Bacteria S anaphase-promoting complex binding - - - - - - - - - - - - PD40,Peptidase_C14,WD40 k59_924950_1 1121033.AUCF01000004_gene5012 5.57e-94 303.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2JPMN@204441|Rhodospirillales 204441|Rhodospirillales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_710695_1 455436.DS989810_gene57 3.89e-06 45.8 COG4736@1|root,COG4736@2|Bacteria 2|Bacteria O Cbb3-type cytochrome oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_710695_2 987059.RBXJA2T_10374 2.48e-53 173.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,1KJRV@119065|unclassified Burkholderiales 28216|Betaproteobacteria C cytochrome C oxidase ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_996094_1 987059.RBXJA2T_00300 1.19e-50 171.0 COG3181@1|root,COG3181@2|Bacteria,1R8KV@1224|Proteobacteria,2VI8E@28216|Betaproteobacteria 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_748583_1 640081.Dsui_1463 4.39e-40 152.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KV0U@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional activator of acetoin glycerol metabolism - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_106948_1 338969.Rfer_0228 8.86e-52 176.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,4ACAF@80864|Comamonadaceae 28216|Betaproteobacteria S benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_748602_1 640081.Dsui_1425 5.45e-58 188.0 COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,2VJP1@28216|Betaproteobacteria,2KVVH@206389|Rhodocyclales 206389|Rhodocyclales S glutamine amidotransferase - - - - - - - - - - - - GATase_4 k59_243164_1 1000565.METUNv1_01496 3.34e-75 239.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,2KW1P@206389|Rhodocyclales 206389|Rhodocyclales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_631770_1 1122211.JMLW01000001_gene2132 3.41e-81 266.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1XHCH@135619|Oceanospirillales 135619|Oceanospirillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_571011_1 497964.CfE428DRAFT_0572 2e-65 213.0 COG3488@1|root,COG3488@2|Bacteria,46T3U@74201|Verrucomicrobia 74201|Verrucomicrobia C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR k59_748648_1 525373.HMPREF0766_10458 2.63e-20 87.4 COG0090@1|root,COG0090@2|Bacteria,4NE8G@976|Bacteroidetes,1INT6@117747|Sphingobacteriia 976|Bacteroidetes J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_748648_2 313603.FB2170_02510 2.89e-30 110.0 COG0089@1|root,COG0089@2|Bacteria,4NS7H@976|Bacteroidetes,1I45R@117743|Flavobacteriia,2PHII@252356|Maribacter 976|Bacteroidetes J Ribosomal protein L23 rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_748648_3 929703.KE386491_gene2511 2.14e-05 46.2 COG0088@1|root,COG0088@2|Bacteria,4NEWZ@976|Bacteroidetes,47J8V@768503|Cytophagia 976|Bacteroidetes J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_243205_1 1000565.METUNv1_00058 3.17e-184 534.0 COG3614@1|root,COG5001@1|root,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2WI5T@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_107021_1 1000565.METUNv1_02790 6.67e-89 281.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,2KU6I@206389|Rhodocyclales 206389|Rhodocyclales E extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_996229_1 85643.Tmz1t_3598 6.3e-87 273.0 COG3950@1|root,COG3950@2|Bacteria,1NT0V@1224|Proteobacteria,2VXZT@28216|Betaproteobacteria 28216|Betaproteobacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 k59_107037_1 76114.ebA4702 3.58e-89 263.0 COG4647@1|root,COG4647@2|Bacteria,1N485@1224|Proteobacteria,2VK8X@28216|Betaproteobacteria,2KUTV@206389|Rhodocyclales 206389|Rhodocyclales Q Acetone carboxylase gamma subunit acxC - 6.4.1.6 ko:K10856 - - - - ko00000,ko01000 - - - Acetone_carb_G k59_1104402_1 1000565.METUNv1_03481 6.26e-152 434.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,2KV0I@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_600384_1 1000565.METUNv1_00329 1.97e-125 369.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,2KURS@206389|Rhodocyclales 206389|Rhodocyclales J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_600384_2 1144342.PMI40_01495 2.2e-20 85.9 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,474U2@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome c nirM - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_940749_1 196162.Noca_1293 1.45e-20 95.9 COG0840@1|root,COG0840@2|Bacteria,2HVFN@201174|Actinobacteria,4DT2P@85009|Propionibacteriales 201174|Actinobacteria NT Methyl-accepting chemotaxis protein (MCP) signalling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_524263_1 640081.Dsui_3004 1.81e-61 211.0 COG0517@1|root,COG2199@1|root,COG2203@1|root,COG2905@1|root,COG0517@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMG7@28216|Betaproteobacteria,2KWIH@206389|Rhodocyclales 206389|Rhodocyclales T PAS domain - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_4 k59_345446_2 1444310.JANV01000162_gene1192 1.03e-13 69.7 COG1694@1|root,COG1694@2|Bacteria,1VIQA@1239|Firmicutes,4HSHR@91061|Bacilli,1ZNVF@1386|Bacillus 91061|Bacilli S MazG nucleotide pyrophosphohydrolase domain - - - - - - - - - - - - MazG k59_51439_1 358220.C380_01805 1.32e-96 293.0 COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,4ABFG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM VanZ family protein - - - - - - - - - - - - VanZ k59_479996_1 1000565.METUNv1_00056 5.73e-124 374.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VQDF@28216|Betaproteobacteria,2KY4C@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_266306_2 666685.R2APBS1_0772 1.12e-22 94.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1X3CN@135614|Xanthomonadales 135614|Xanthomonadales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_345475_1 642492.Clole_2126 2.82e-13 74.3 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia 186801|Clostridia H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_1052197_1 1000565.METUNv1_02117 2.85e-97 296.0 COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,2KVEI@206389|Rhodocyclales 206389|Rhodocyclales S NMT1-like family - - - - - - - - - - - - NMT1_3 k59_86393_1 1121870.AUAA01000001_gene2759 2.16e-11 71.6 COG1345@1|root,COG3420@1|root,COG4733@1|root,COG1345@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,4NGSK@976|Bacteroidetes,1HXWK@117743|Flavobacteriia 976|Bacteroidetes N Zinc metalloprotease (Elastase) - - - - - - - - - - - - ASH,TIG k59_728764_1 95619.PM1_0214655 9.55e-46 167.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase bifA - 3.1.4.52 ko:K21024 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,PAS_3 k59_691939_1 1000565.METUNv1_00280 2.68e-49 168.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,2KUJ5@206389|Rhodocyclales 206389|Rhodocyclales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nasF - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2,TAT_signal k59_407269_1 1000565.METUNv1_00150 1.21e-116 362.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VPUH@28216|Betaproteobacteria,2KW4J@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_977303_1 29581.BW37_05475 4.38e-33 118.0 COG0810@1|root,COG0810@2|Bacteria,1PWYU@1224|Proteobacteria,2WCGS@28216|Betaproteobacteria,477K8@75682|Oxalobacteraceae 28216|Betaproteobacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_940793_1 85643.Tmz1t_1958 3.12e-24 102.0 COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2VM8I@28216|Betaproteobacteria,2KV4E@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_940793_2 1454004.AW11_02163 7.8e-33 118.0 COG2703@1|root,COG2703@2|Bacteria,1MY70@1224|Proteobacteria 1224|Proteobacteria P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_480048_1 414684.RC1_4110 8.13e-58 186.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2JPSB@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein, beta subunit etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_1119924_1 204669.Acid345_2739 4.24e-12 71.6 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_266359_1 929713.NIASO_09245 6.17e-28 111.0 COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1IQ1B@117747|Sphingobacteriia 976|Bacteroidetes C PFAM Cytochrome C oxidase subunit II, periplasmic domain nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_266359_2 1121896.JMLU01000024_gene2527 6.71e-36 130.0 COG2335@1|root,COG2335@2|Bacteria,4NMPI@976|Bacteroidetes,1I1DK@117743|Flavobacteriia,2NV62@237|Flavobacterium 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_202727_1 1122951.ATUE01000005_gene1531 1.35e-114 342.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,3NIMZ@468|Moraxellaceae 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_524396_1 573591.B7SYF8_9CAUD 2.51e-20 95.5 4QAQE@10239|Viruses,4QUYF@35237|dsDNA viruses no RNA stage,4QU2B@28883|Caudovirales,4QKXA@10699|Siphoviridae 10699|Siphoviridae S Pfam:Arm-DNA-bind_3 - - - - - - - - - - - - - k59_762461_1 543728.Vapar_0403 1.24e-62 192.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,4AEF4@80864|Comamonadaceae 28216|Betaproteobacteria J sigma 54 modulation protein ribosomal protein S30EA raiA - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_550059_1 395493.BegalDRAFT_1919 1.45e-11 68.9 COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,1RZ9J@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Esterase PHB depolymerase - - - - - - - - - - - - Esterase,Esterase_phd k59_691996_1 1000565.METUNv1_01312 1.23e-140 408.0 COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,2KW2J@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - - - - - - - - - - ZipA_C k59_691996_2 1000565.METUNv1_01311 6.81e-49 172.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,2KUWJ@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_667781_1 640081.Dsui_2219 5.68e-142 413.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUQ1@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_303382_1 1000565.METUNv1_02830 8.92e-110 322.0 COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria,2KUFS@206389|Rhodocyclales 206389|Rhodocyclales H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group - - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_940826_1 358220.C380_10720 1.82e-44 152.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,4ADHE@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1091078_1 1500894.JQNN01000001_gene3921 6.4e-22 100.0 COG2194@1|root,COG2194@2|Bacteria,1R7XW@1224|Proteobacteria,2WEF2@28216|Betaproteobacteria,4726B@75682|Oxalobacteraceae 28216|Betaproteobacteria S Sulfatase - - - - - - - - - - - - DUF1705,Sulfatase k59_524424_1 614083.AWQR01000035_gene3636 4.63e-122 361.0 COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2VIP8@28216|Betaproteobacteria,4A9MW@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM PHB de-polymerase domain protein phaZ - 3.1.1.75 ko:K05973 ko00650,map00650 - R05118 - ko00000,ko00001,ko01000 - - - PHB_depo_C k59_15158_1 1236541.BALL01000024_gene2929 2.9e-12 71.2 COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,1RMF5@1236|Gammaproteobacteria,2QAY5@267890|Shewanellaceae 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_940828_1 1276756.AUEX01000025_gene2038 5.13e-46 156.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,4ABG6@80864|Comamonadaceae 28216|Betaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1119972_1 83406.HDN1F_04960 1.72e-88 262.0 COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,1S6KW@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodC GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - iEcolC_1368.EcolC_1983 Sod_Cu k59_1119972_2 257313.BP2134 7.63e-17 73.9 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2VSQ1@28216|Betaproteobacteria,3T4VH@506|Alcaligenaceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_871854_1 1121035.AUCH01000001_gene2105 2.67e-34 128.0 COG0330@1|root,COG0330@2|Bacteria,1RDFI@1224|Proteobacteria,2VTRM@28216|Betaproteobacteria 28216|Betaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_871854_2 1121035.AUCH01000001_gene2106 7.41e-33 125.0 COG4615@1|root,COG4615@2|Bacteria,1MVIC@1224|Proteobacteria,2VJPD@28216|Betaproteobacteria 28216|Betaproteobacteria PQ Cyclic peptide transporter - - - ko:K06160 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.113.2 - - ABC_tran k59_51562_1 1283284.AZUK01000001_gene164 5.53e-69 233.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Y5HR@135624|Aeromonadales 135624|Aeromonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_3,PAS_4 k59_51565_1 159087.Daro_2977 1.93e-116 340.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,2KUAU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_202824_1 1380387.JADM01000004_gene2941 4.02e-15 69.7 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S4NE@1236|Gammaproteobacteria,1XK3S@135619|Oceanospirillales 135619|Oceanospirillales T COG0784 FOG CheY-like receiver - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_202824_2 1215092.PA6_003_00290 2.29e-73 221.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1YFTK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KT Response regulator receiver domain pilG - - ko:K02657,ko:K03413 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_583620_1 1000565.METUNv1_04058 1.25e-171 505.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,2KU82@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_692057_1 614083.AWQR01000029_gene2157 1.94e-140 406.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,4AAY9@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_550139_1 1123487.KB892834_gene2973 1.67e-97 301.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria,2KWC0@206389|Rhodocyclales 206389|Rhodocyclales MU RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_667900_1 511062.GU3_09875 6.93e-37 135.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1Y3G6@135624|Aeromonadales 135624|Aeromonadales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_667900_2 34506.g5525 4.01e-11 62.8 COG0236@1|root,COG0304@1|root,KOG1394@2759|Eukaryota,KOG1748@2759|Eukaryota,38H9Y@33154|Opisthokonta,3BF6J@33208|Metazoa,3CYM9@33213|Bilateria,40CW1@6231|Nematoda,1KW4F@119089|Chromadorea,40RR3@6236|Rhabditida 33208|Metazoa IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_524509_3 1122201.AUAZ01000021_gene3152 1.56e-119 356.0 28W6R@1|root,2ZI7D@2|Bacteria,1N49N@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1015134_1 595537.Varpa_6016 3.3e-41 151.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,4AABC@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1015134_2 338969.Rfer_4239 3.94e-87 259.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2VI7G@28216|Betaproteobacteria,4ACVK@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003999,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0012505,GO:0016192,GO:0016208,GO:0016740,GO:0016757,GO:0016763,GO:0017076,GO:0018130,GO:0019438,GO:0030141,GO:0030554,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_15203_1 270374.MELB17_24012 6.41e-12 61.2 2C5K0@1|root,32ZXC@2|Bacteria,1N9KG@1224|Proteobacteria,1SIRZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_15203_7 1121351.AUAP01000001_gene582 3.05e-15 71.6 2E3UI@1|root,32YRW@2|Bacteria,1N9KV@1224|Proteobacteria,2VX82@28216|Betaproteobacteria,2KS41@206351|Neisseriales 206351|Neisseriales S Pyocin activator protein PrtN - - - - - - - - - - - - PyocinActivator k59_15203_8 76114.ebA7273 2.56e-120 348.0 28J67@1|root,2Z91Y@2|Bacteria,1R7RG@1224|Proteobacteria,2VRTM@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_907982_2 1000565.METUNv1_01009 2.12e-20 90.1 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KUV9@206389|Rhodocyclales 206389|Rhodocyclales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1052443_1 338969.Rfer_0565 4.54e-62 194.0 2CBCJ@1|root,2ZYBR@2|Bacteria,1REF3@1224|Proteobacteria,2VS3N@28216|Betaproteobacteria,4AE3Z@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_51597_1 666681.M301_1693 5.28e-51 163.0 2AX91@1|root,31P80@2|Bacteria,1N25K@1224|Proteobacteria,2VSYQ@28216|Betaproteobacteria,2KMYF@206350|Nitrosomonadales 206350|Nitrosomonadales N Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways flhD - - ko:K02403 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlhD k59_51597_2 1502770.JQMG01000001_gene1862 5.78e-06 47.0 2DBG4@1|root,2Z927@2|Bacteria,1N7I6@1224|Proteobacteria,2VQ2P@28216|Betaproteobacteria,2KKT9@206350|Nitrosomonadales 206350|Nitrosomonadales N Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways flhC - - ko:K02402 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlhC k59_907985_1 1095769.CAHF01000018_gene785 2.1e-41 138.0 COG0599@1|root,COG0599@2|Bacteria,1NN7W@1224|Proteobacteria,2VWHN@28216|Betaproteobacteria 28216|Betaproteobacteria S decarboxylase - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_907985_2 990285.RGCCGE502_26038 9.05e-16 75.5 COG0583@1|root,COG0583@2|Bacteria,1R49T@1224|Proteobacteria,2U6BN@28211|Alphaproteobacteria,4B9MZ@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator pecT - - - - - - - - - - - HTH_1,LysR_substrate k59_836939_1 265072.Mfla_0159 2.19e-26 109.0 COG2197@1|root,COG2197@2|Bacteria,1R6Y9@1224|Proteobacteria,2VV7Q@28216|Betaproteobacteria,2KNTR@206350|Nitrosomonadales 206350|Nitrosomonadales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_836941_1 1458275.AZ34_13310 5.16e-125 372.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,4AACA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_51608_1 1223521.BBJX01000009_gene1158 3.3e-107 326.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,4AAMH@80864|Comamonadaceae 28216|Betaproteobacteria J TIGRFAM glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_374410_1 269796.Rru_A0092 6.54e-135 395.0 COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2TUCZ@28211|Alphaproteobacteria,2JRMC@204441|Rhodospirillales 204441|Rhodospirillales G COG1653 ABC-type sugar transport system, periplasmic component - - - ko:K17315 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - SBP_bac_1 k59_802255_1 1000565.METUNv1_02964 2.52e-125 368.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,2KVMP@206389|Rhodocyclales 206389|Rhodocyclales S sulfide dehydrogenase soxF - 1.8.2.1 ko:K05301 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00528 RC00168 ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_1055470_2 509635.N824_02290 0.00067 43.1 COG0457@1|root,COG0457@2|Bacteria,4PNC5@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1055477_1 497321.C664_02885 1.23e-97 291.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,2KUD7@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_764253_1 365046.Rta_37300 4.33e-20 94.4 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,4AAZX@80864|Comamonadaceae 28216|Betaproteobacteria S peptidase M48, Ste24p yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_124240_1 118173.KB235914_gene884 2.18e-50 170.0 COG0005@1|root,COG0005@2|Bacteria,1G1F3@1117|Cyanobacteria,1H85M@1150|Oscillatoriales 1117|Cyanobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_764254_1 1100721.ALKO01000003_gene2084 2.02e-100 303.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,4ABGI@80864|Comamonadaceae 28216|Betaproteobacteria EGP Nucleoside H+ symporter hcaT - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_1138582_1 926559.JoomaDRAFT_2881 2.84e-35 134.0 COG0726@1|root,COG0726@2|Bacteria,4NF79@976|Bacteroidetes,1HWXT@117743|Flavobacteriia 976|Bacteroidetes G polysaccharide deacetylase - - - - - - - - - - - - - k59_779432_1 1123008.KB905694_gene1651 6.69e-33 125.0 COG1073@1|root,COG1073@2|Bacteria,4NG6A@976|Bacteroidetes,2FPAE@200643|Bacteroidia,22YCE@171551|Porphyromonadaceae 976|Bacteroidetes S alpha beta - - - - - - - - - - - - - k59_819376_1 614083.AWQR01000025_gene3740 1.08e-104 324.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,4AAXI@80864|Comamonadaceae 28216|Betaproteobacteria C Phosphate acetyl butaryl transferase maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_178145_2 291112.PAU_03136 8.88e-56 186.0 COG0417@1|root,COG0417@2|Bacteria,1QVMG@1224|Proteobacteria,1T2EP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Predicted 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_178145_3 1268622.AVS7_00674 1.72e-87 264.0 2AITR@1|root,319AT@2|Bacteria,1RHGX@1224|Proteobacteria,2VSCG@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_69846_2 159087.Daro_1865 7.3e-25 96.3 2EC8Y@1|root,3367B@2|Bacteria,1NFHG@1224|Proteobacteria,2VWKX@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_69846_3 1157708.KB907455_gene3242 7.16e-37 135.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,4A9QN@80864|Comamonadaceae 28216|Betaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_819398_1 1218075.BAYA01000004_gene1556 6.14e-08 59.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K2XE@119060|Burkholderiaceae 28216|Betaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH,sCache_2 k59_1103914_1 485918.Cpin_1040 1.11e-44 158.0 COG1215@1|root,COG1215@2|Bacteria,4NG9C@976|Bacteroidetes,1IPRP@117747|Sphingobacteriia 976|Bacteroidetes M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_69887_1 1100721.ALKO01000017_gene1585 1.58e-121 364.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4AC0U@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_178199_1 886293.Sinac_2778 2.54e-53 190.0 COG3119@1|root,COG3119@2|Bacteria,2IX0Y@203682|Planctomycetes 203682|Planctomycetes P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_779490_1 381666.H16_B0091 2.72e-109 327.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,1K15N@119060|Burkholderiaceae 28216|Betaproteobacteria C TIGRFAM iron-sulfur cluster binding protein lutB - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_140946_1 1485544.JQKP01000002_gene1529 7.85e-64 212.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,44VAU@713636|Nitrosomonadales 28216|Betaproteobacteria M PFAM membrane bound O-acyl transferase MBOAT family protein pacA - - - - - - - - - - - MBOAT k59_710407_1 365046.Rta_25380 1.68e-141 431.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,4ACU7@80864|Comamonadaceae 28216|Betaproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_748295_1 614083.AWQR01000009_gene687 7.69e-12 64.7 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,4ACWB@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase pleD - - - - - - - - - - - GGDEF,Response_reg,SBP_bac_3 k59_748295_2 614083.AWQR01000009_gene685 1.65e-41 148.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,4AAKC@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_956910_1 864051.BurJ1DRAFT_4175 3.6e-37 144.0 COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_570727_1 748247.AZKH_0851 1.25e-168 486.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJ2@28216|Betaproteobacteria,2KUZM@206389|Rhodocyclales 206389|Rhodocyclales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_242892_1 640081.Dsui_1393 2.23e-120 361.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUQA@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_600049_1 312153.Pnuc_1599 2.56e-140 402.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,1JZYI@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_600049_2 1458427.BAWN01000020_gene1250 2.27e-24 99.4 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,4ABH1@80864|Comamonadaceae 28216|Betaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1103991_1 1122951.ATUE01000007_gene546 5e-106 320.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,3NJ7Y@468|Moraxellaceae 1236|Gammaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0022411,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032984,GO:0034641,GO:0034645,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_995832_1 529818.AMSG_03185T0 5.49e-75 229.0 COG1100@1|root,KOG0395@2759|Eukaryota 2759|Eukaryota G GTPase activity KRAS GO:0000003,GO:0000075,GO:0000082,GO:0000139,GO:0000165,GO:0000166,GO:0000278,GO:0000578,GO:0000902,GO:0000904,GO:0001558,GO:0001562,GO:0001654,GO:0001655,GO:0001667,GO:0001700,GO:0001708,GO:0001709,GO:0001745,GO:0001751,GO:0001752,GO:0001754,GO:0001763,GO:0001775,GO:0001817,GO:0001819,GO:0001882,GO:0001883,GO:0001889,GO:0001894,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002119,GO:0002164,GO:0002165,GO:0002168,GO:0002218,GO:0002220,GO:0002223,GO:0002250,GO:0002252,GO:0002253,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002429,GO:0002443,GO:0002444,GO:0002446,GO:0002460,GO:0002520,GO:0002682,GO:0002684,GO:0002757,GO:0002758,GO:0002764,GO:0002768,GO:0003002,GO:0003006,GO:0003008,GO:0003674,GO:0003824,GO:0003924,GO:0005085,GO:0005088,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005886,GO:0005938,GO:0006275,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006606,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006886,GO:0006887,GO:0006897,GO:0006913,GO:0006915,GO:0006928,GO:0006935,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007010,GO:0007049,GO:0007050,GO:0007093,GO:0007154,GO:0007163,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007173,GO:0007264,GO:0007265,GO:0007267,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007298,GO:0007304,GO:0007308,GO:0007309,GO:0007346,GO:0007350,GO:0007351,GO:0007369,GO:0007389,GO:0007391,GO:0007395,GO:0007399,GO:0007417,GO:0007420,GO:0007422,GO:0007423,GO:0007424,GO:0007426,GO:0007428,GO:0007444,GO:0007455,GO:0007465,GO:0007472,GO:0007476,GO:0007507,GO:0007517,GO:0007552,GO:0007560,GO:0007565,GO:0007568,GO:0007569,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007614,GO:0007632,GO:0008022,GO:0008104,GO:0008150,GO:0008152,GO:0008219,GO:0008283,GO:0008284,GO:0008285,GO:0008293,GO:0008306,GO:0008340,GO:0008361,GO:0008542,GO:0008586,GO:0008594,GO:0008595,GO:0009267,GO:0009314,GO:0009416,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009791,GO:0009792,GO:0009798,GO:0009880,GO:0009886,GO:0009887,GO:0009888,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009898,GO:0009948,GO:0009952,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0009994,GO:0010001,GO:0010033,GO:0010212,GO:0010259,GO:0010332,GO:0010453,GO:0010468,GO:0010506,GO:0010507,GO:0010517,GO:0010518,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010631,GO:0010638,GO:0010646,GO:0010647,GO:0010648,GO:0010720,GO:0010721,GO:0010863,GO:0010941,GO:0012501,GO:0012505,GO:0012506,GO:0014002,GO:0014070,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016202,GO:0016241,GO:0016242,GO:0016310,GO:0016331,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017016,GO:0017034,GO:0017038,GO:0017076,GO:0017111,GO:0019001,GO:0019002,GO:0019003,GO:0019219,GO:0019220,GO:0019221,GO:0019222,GO:0019538,GO:0019897,GO:0019898,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019953,GO:0021700,GO:0021782,GO:0021896,GO:0021897,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022603,GO:0022607,GO:0023014,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030097,GO:0030141,GO:0030154,GO:0030182,GO:0030275,GO:0030307,GO:0030323,GO:0030324,GO:0030334,GO:0030335,GO:0030381,GO:0030659,GO:0030667,GO:0030703,GO:0030707,GO:0030855,GO:0030900,GO:0031090,GO:0031234,GO:0031267,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031344,GO:0031346,GO:0031347,GO:0031349,GO:0031399,GO:0031401,GO:0031410,GO:0031647,GO:0031667,GO:0031668,GO:0031669,GO:0031929,GO:0031960,GO:0031982,GO:0031984,GO:0032228,GO:0032268,GO:0032270,GO:0032386,GO:0032388,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032649,GO:0032729,GO:0032768,GO:0032770,GO:0032872,GO:0032874,GO:0032879,GO:0032880,GO:0032940,GO:0032956,GO:0032970,GO:0032989,GO:0033036,GO:0033043,GO:0033157,GO:0033365,GO:0033554,GO:0033674,GO:0033993,GO:0034097,GO:0034260,GO:0034504,GO:0034613,GO:0035020,GO:0035022,GO:0035088,GO:0035099,GO:0035107,GO:0035114,GO:0035120,GO:0035162,GO:0035206,GO:0035208,GO:0035214,GO:0035220,GO:0035239,GO:0035282,GO:0035295,GO:0035556,GO:0035639,GO:0035900,GO:0036094,GO:0036211,GO:0036230,GO:0036335,GO:0038002,GO:0038127,GO:0038202,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040017,GO:0040025,GO:0040026,GO:0040028,GO:0042063,GO:0042088,GO:0042119,GO:0042127,GO:0042221,GO:0042325,GO:0042327,GO:0042330,GO:0042461,GO:0042592,GO:0042594,GO:0042659,GO:0042692,GO:0042706,GO:0042802,GO:0042832,GO:0042886,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043086,GO:0043087,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043274,GO:0043299,GO:0043312,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043523,GO:0043524,GO:0043547,GO:0043549,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0044706,GO:0044770,GO:0044772,GO:0044843,GO:0044877,GO:0045055,GO:0045088,GO:0045089,GO:0045121,GO:0045165,GO:0045184,GO:0045321,GO:0045466,GO:0045500,GO:0045595,GO:0045596,GO:0045597,GO:0045610,GO:0045664,GO:0045666,GO:0045740,GO:0045765,GO:0045766,GO:0045786,GO:0045793,GO:0045843,GO:0045859,GO:0045860,GO:0045893,GO:0045927,GO:0045930,GO:0045935,GO:0045937,GO:0045944,GO:0046328,GO:0046330,GO:0046530,GO:0046532,GO:0046534,GO:0046552,GO:0046578,GO:0046579,GO:0046668,GO:0046669,GO:0046671,GO:0046673,GO:0046903,GO:0046907,GO:0048013,GO:0048145,GO:0048146,GO:0048167,GO:0048168,GO:0048169,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048545,GO:0048563,GO:0048568,GO:0048569,GO:0048580,GO:0048582,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048598,GO:0048599,GO:0048609,GO:0048634,GO:0048635,GO:0048638,GO:0048641,GO:0048642,GO:0048646,GO:0048663,GO:0048666,GO:0048667,GO:0048699,GO:0048707,GO:0048708,GO:0048729,GO:0048731,GO:0048732,GO:0048736,GO:0048737,GO:0048749,GO:0048754,GO:0048856,GO:0048863,GO:0048865,GO:0048869,GO:0048870,GO:0048871,GO:0048872,GO:0048873,GO:0050678,GO:0050679,GO:0050767,GO:0050769,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050804,GO:0050851,GO:0050852,GO:0050877,GO:0050886,GO:0050890,GO:0050896,GO:0050999,GO:0051000,GO:0051020,GO:0051049,GO:0051050,GO:0051052,GO:0051054,GO:0051056,GO:0051057,GO:0051090,GO:0051091,GO:0051092,GO:0051093,GO:0051094,GO:0051128,GO:0051130,GO:0051146,GO:0051169,GO:0051170,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051259,GO:0051270,GO:0051272,GO:0051291,GO:0051336,GO:0051338,GO:0051341,GO:0051345,GO:0051346,GO:0051347,GO:0051353,GO:0051384,GO:0051385,GO:0051493,GO:0051495,GO:0051607,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0051960,GO:0051962,GO:0060191,GO:0060193,GO:0060249,GO:0060255,GO:0060284,GO:0060322,GO:0060341,GO:0060425,GO:0060429,GO:0060438,GO:0060441,GO:0060446,GO:0060491,GO:0060541,GO:0060548,GO:0060562,GO:0061008,GO:0061041,GO:0061061,GO:0061062,GO:0061063,GO:0061138,GO:0061245,GO:0061326,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070302,GO:0070304,GO:0070372,GO:0070374,GO:0070727,GO:0070820,GO:0070821,GO:0070887,GO:0071214,GO:0071310,GO:0071345,GO:0071478,GO:0071479,GO:0071480,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071900,GO:0071902,GO:0071944,GO:0072001,GO:0072002,GO:0072089,GO:0072325,GO:0072327,GO:0072359,GO:0072594,GO:0080090,GO:0080134,GO:0080135,GO:0090066,GO:0090087,GO:0090130,GO:0090132,GO:0090303,GO:0090313,GO:0090314,GO:0090316,GO:0090342,GO:0090343,GO:0090398,GO:0090596,GO:0097159,GO:0097190,GO:0097193,GO:0097367,GO:0097708,GO:0098542,GO:0098552,GO:0098562,GO:0098588,GO:0098589,GO:0098657,GO:0098772,GO:0098791,GO:0098805,GO:0098857,GO:0099177,GO:0099503,GO:0099568,GO:0104004,GO:0120032,GO:0120034,GO:0120035,GO:1900027,GO:1900029,GO:1900274,GO:1901214,GO:1901215,GO:1901265,GO:1901342,GO:1901363,GO:1901564,GO:1901861,GO:1901862,GO:1902531,GO:1902533,GO:1902680,GO:1902683,GO:1902685,GO:1903034,GO:1903036,GO:1903047,GO:1903506,GO:1903508,GO:1903533,GO:1903827,GO:1903829,GO:1904018,GO:1904951,GO:1905475,GO:1905477,GO:2000026,GO:2000027,GO:2000112,GO:2000145,GO:2000147,GO:2000249,GO:2000251,GO:2000628,GO:2000630,GO:2000772,GO:2000774,GO:2001141,GO:2001233,GO:2001234 - ko:K02833,ko:K07208,ko:K07827,ko:K07828 ko01521,ko01522,ko04010,ko04012,ko04013,ko04014,ko04015,ko04062,ko04068,ko04071,ko04072,ko04137,ko04138,ko04140,ko04144,ko04150,ko04151,ko04152,ko04210,ko04211,ko04213,ko04214,ko04218,ko04320,ko04360,ko04370,ko04371,ko04510,ko04540,ko04550,ko04630,ko04650,ko04660,ko04662,ko04664,ko04714,ko04720,ko04722,ko04725,ko04726,ko04730,ko04810,ko04910,ko04912,ko04914,ko04915,ko04916,ko04917,ko04919,ko04921,ko04926,ko04933,ko04960,ko05034,ko05160,ko05161,ko05165,ko05166,ko05167,ko05200,ko05203,ko05205,ko05206,ko05210,ko05211,ko05212,ko05213,ko05214,ko05215,ko05216,ko05218,ko05219,ko05220,ko05221,ko05223,ko05224,ko05225,ko05226,ko05230,ko05231,map01521,map01522,map04010,map04012,map04013,map04014,map04015,map04062,map04068,map04071,map04072,map04137,map04138,map04140,map04144,map04150,map04151,map04152,map04210,map04211,map04213,map04214,map04218,map04320,map04360,map04370,map04371,map04510,map04540,map04550,map04630,map04650,map04660,map04662,map04664,map04714,map04720,map04722,map04725,map04726,map04730,map04810,map04910,map04912,map04914,map04915,map04916,map04917,map04919,map04921,map04926,map04933,map04960,map05034,map05160,map05161,map05165,map05166,map05167,map05200,map05203,map05205,map05206,map05210,map05211,map05212,map05213,map05214,map05215,map05216,map05218,map05219,map05220,map05221,map05223,map05224,map05225,map05226,map05230,map05231 - - - ko00000,ko00001,ko04031,ko04131,ko04147 - - - Ras k59_600103_1 287.DR97_2953 1.03e-119 365.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1YEV8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_33661_1 981384.AEYW01000014_gene75 1.43e-06 49.3 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,2U7G8@28211|Alphaproteobacteria,4NCB9@97050|Ruegeria 28211|Alphaproteobacteria G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_33661_2 1216976.AX27061_0244 2.62e-46 162.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,3T369@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_637981_1 1185876.BN8_00781 6.29e-58 194.0 COG5267@1|root,COG5267@2|Bacteria,4NHSB@976|Bacteroidetes,47MD4@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_638086_1 1000565.METUNv1_02581 4.06e-47 171.0 28IWG@1|root,2Z8US@2|Bacteria,1NHDW@1224|Proteobacteria,2VPYM@28216|Betaproteobacteria,2KY8N@206389|Rhodocyclales 206389|Rhodocyclales S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_638269_2 981327.F925_00664 1.61e-09 59.7 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,3NIEF@468|Moraxellaceae 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_638281_1 1123255.JHYS01000006_gene373 4.8e-46 156.0 2E3S7@1|root,32YPT@2|Bacteria,1N7D4@1224|Proteobacteria,2VUS8@28216|Betaproteobacteria,4AGCI@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_638281_2 264730.PSPPH_1762 2.02e-14 69.3 COG1522@1|root,COG1522@2|Bacteria,1RB37@1224|Proteobacteria,1S08R@1236|Gammaproteobacteria,1Z6DD@136849|Pseudomonas syringae group 1236|Gammaproteobacteria K helix_turn_helix ASNC type acdR - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_638421_1 466088.CL42_05435 2.19e-106 317.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,3NKPI@468|Moraxellaceae 1236|Gammaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_638573_1 1217656.F964_01314 1.49e-109 329.0 COG3239@1|root,COG3239@2|Bacteria,1MXTQ@1224|Proteobacteria,1RRM8@1236|Gammaproteobacteria,3NM49@468|Moraxellaceae 1236|Gammaproteobacteria I fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_639026_1 1340493.JNIF01000003_gene1952 5.48e-54 192.0 COG0841@1|root,COG0841@2|Bacteria,3Y6DS@57723|Acidobacteria 57723|Acidobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP k59_639155_1 1095769.CAHF01000011_gene2658 1.77e-129 371.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2VIR0@28216|Betaproteobacteria,4733M@75682|Oxalobacteraceae 28216|Betaproteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_639623_1 640081.Dsui_1210 3.33e-10 59.3 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KUN3@206389|Rhodocyclales 206389|Rhodocyclales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_639623_2 159087.Daro_0528 3.64e-57 182.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,2KWI1@206389|Rhodocyclales 206389|Rhodocyclales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_639670_1 1005048.CFU_3919 0.000199 42.7 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,472U8@75682|Oxalobacteraceae 28216|Betaproteobacteria K Likely ribonuclease with RNase H fold. tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_639786_1 1353529.M899_2158 1.56e-46 164.0 COG0513@1|root,COG0513@2|Bacteria,1NUZU@1224|Proteobacteria,42ZQT@68525|delta/epsilon subdivisions,2MTUN@213481|Bdellovibrionales,2WUYJ@28221|Deltaproteobacteria 213481|Bdellovibrionales JKL helicase superfamily c-terminal domain - - - - - - - - - - - - DEAD,Helicase_C k59_639824_1 1107311.Q767_09885 8.01e-100 311.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes,1HWXD@117743|Flavobacteriia,2NSKT@237|Flavobacterium 976|Bacteroidetes E aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_640015_2 1000565.METUNv1_00103 6.49e-125 373.0 COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria,2KUK9@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase-like ATPases - - - - - - - - - - - - - k59_640040_1 338969.Rfer_2548 1.5e-07 52.0 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VRGJ@28216|Betaproteobacteria,4AJFV@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_640040_2 1198452.Jab_1c08850 2.24e-13 72.4 COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria 28216|Betaproteobacteria K transmembrane transcriptional regulator (Anti-sigma factor) prtR - - - - - - - - - - - zf-HC2 k59_640276_2 420662.Mpe_B0099 1.42e-20 97.1 COG5377@1|root,COG5377@2|Bacteria,1PU6P@1224|Proteobacteria,2VWXY@28216|Betaproteobacteria 28216|Betaproteobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_640319_1 497321.C664_17060 5.94e-76 249.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_640319_2 640081.Dsui_0228 1.71e-55 182.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,2KW63@206389|Rhodocyclales 206389|Rhodocyclales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_640603_1 1100720.ALKN01000048_gene2372 1.49e-86 258.0 COG2197@1|root,COG2197@2|Bacteria,1RAAY@1224|Proteobacteria,2VQ17@28216|Betaproteobacteria,4AAHC@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein LuxR - - - - - - - - - - - - GerE,PAS_9 k59_640686_1 1121935.AQXX01000097_gene1698 1.05e-17 80.5 COG1309@1|root,COG1309@2|Bacteria,1QIJW@1224|Proteobacteria,1SDIA@1236|Gammaproteobacteria,1XRQS@135619|Oceanospirillales 135619|Oceanospirillales K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_N k59_640686_2 1411685.U062_00071 1.99e-25 106.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,1SJUT@1236|Gammaproteobacteria,1J957@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_640727_1 1122989.KB898591_gene738 1.28e-08 55.8 COG0151@1|root,COG0151@2|Bacteria,4NEUN@976|Bacteroidetes,2FN59@200643|Bacteroidia 976|Bacteroidetes F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_640727_2 1235803.C825_03639 3.43e-13 76.3 COG0457@1|root,COG0457@2|Bacteria,4NRRJ@976|Bacteroidetes,2FNWU@200643|Bacteroidia,231DJ@171551|Porphyromonadaceae 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_12,TPR_8 k59_640879_1 614083.AWQR01000041_gene829 1.39e-156 448.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,4AB5P@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_641175_2 1114970.PSF113_2334 5.72e-30 118.0 COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,1RZKS@1236|Gammaproteobacteria,1YQE2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation k59_641487_1 420662.Mpe_A1745 1.1e-79 250.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VJXD@28216|Betaproteobacteria,1KKYW@119065|unclassified Burkholderiales 28216|Betaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_641639_1 1100720.ALKN01000030_gene1050 3.02e-81 253.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,4AC5P@80864|Comamonadaceae 28216|Betaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_641762_1 365046.Rta_09150 1.37e-98 296.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,4AAAT@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_642222_1 929713.NIASO_12805 3.07e-05 47.4 2A7CX@1|root,334RT@2|Bacteria,4NVQR@976|Bacteroidetes 976|Bacteroidetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl_2 k59_642292_1 748247.AZKH_3439 1.39e-247 691.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KVHE@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_642292_2 748247.AZKH_3438 2.75e-219 617.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,2KW6A@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_428985_2 1000565.METUNv1_02386 2.39e-107 325.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUBK@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_179162_1 215803.DB30_3128 5.29e-42 152.0 COG2273@1|root,COG3291@1|root,COG2273@2|Bacteria,COG3291@2|Bacteria,1QX66@1224|Proteobacteria,437XJ@68525|delta/epsilon subdivisions,2X37H@28221|Deltaproteobacteria,2YUQ0@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolase catalytic core - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_cc k59_535793_2 640081.Dsui_1200 5.58e-37 141.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KUWE@206389|Rhodocyclales 206389|Rhodocyclales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_892815_1 331869.BAL199_12136 5.82e-10 65.5 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2TRZB@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 k59_821411_1 1000565.METUNv1_00780 2.79e-126 369.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,2KV70@206389|Rhodocyclales 206389|Rhodocyclales E Aminotransferase - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_821411_2 1000565.METUNv1_00781 3.93e-70 215.0 COG0454@1|root,COG0456@2|Bacteria,1N506@1224|Proteobacteria,2VUBB@28216|Betaproteobacteria,2KZC5@206389|Rhodocyclales 206389|Rhodocyclales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_821411_3 1000565.METUNv1_00782 3.8e-166 473.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,2KV2B@206389|Rhodocyclales 206389|Rhodocyclales E homoserine dehydrogenase thrA - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_643203_1 1000565.METUNv1_02445 1.56e-70 240.0 COG3170@1|root,COG3170@2|Bacteria,1RE27@1224|Proteobacteria,2VRNH@28216|Betaproteobacteria,2KW0V@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_357560_1 1000565.METUNv1_03515 3.62e-07 50.8 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,2KUZK@206389|Rhodocyclales 206389|Rhodocyclales S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_357560_2 1000565.METUNv1_03514 2.45e-128 393.0 COG0642@1|root,COG3614@1|root,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,2WHGB@28216|Betaproteobacteria,2KY19@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_612_2 748280.NH8B_2399 9.48e-47 161.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VM8V@28216|Betaproteobacteria,2KTST@206351|Neisseriales 206351|Neisseriales G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_464564_1 1000565.METUNv1_01597 4.14e-65 216.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,2KUNW@206389|Rhodocyclales 206389|Rhodocyclales O Cytochrome c ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_464564_2 522306.CAP2UW1_0722 4.26e-78 238.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,1KQKF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria CO Redoxin dsbE - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_464564_3 1000565.METUNv1_01595 1.2e-63 199.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,2KX2W@206389|Rhodocyclales 206389|Rhodocyclales P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH k59_429003_1 1265502.KB905929_gene2154 2.5e-05 45.4 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2VHMJ@28216|Betaproteobacteria,4AAE3@80864|Comamonadaceae 28216|Betaproteobacteria N PFAM OmpA MotB domain protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_429003_2 420662.Mpe_A2872 1.82e-128 374.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VHPX@28216|Betaproteobacteria,1KJE3@119065|unclassified Burkholderiales 28216|Betaproteobacteria N MotA/TolQ/ExbB proton channel family motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_321962_1 1000565.METUNv1_03645 1.05e-161 458.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,2KUUY@206389|Rhodocyclales 206389|Rhodocyclales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_821424_1 1000565.METUNv1_03849 1.34e-91 272.0 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2VS6T@28216|Betaproteobacteria,2M01P@206389|Rhodocyclales 206389|Rhodocyclales M OmpW family - - - - - - - - - - - - OmpW k59_471054_1 85643.Tmz1t_3024 2.78e-86 258.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,2KVGW@206389|Rhodocyclales 206389|Rhodocyclales J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_611187_1 1000565.METUNv1_03365 2.2e-51 164.0 COG0640@1|root,COG0640@2|Bacteria,1MZPS@1224|Proteobacteria,2VUHJ@28216|Betaproteobacteria,2KX18@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 k59_611187_2 335283.Neut_1418 6.81e-29 116.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VK3J@28216|Betaproteobacteria,3725A@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Orn DAP Arg decarboxylase 2 - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_828628_1 1000565.METUNv1_03502 3.15e-75 232.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,2KUMP@206389|Rhodocyclales 206389|Rhodocyclales S COG0714 MoxR-like ATPases - - - - - - - - - - - - AAA_5,CbbQ_C k59_828628_2 1000565.METUNv1_03501 1.23e-99 308.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,2KUMB@206389|Rhodocyclales 206389|Rhodocyclales P Von Willebrand factor type A - - - - - - - - - - - - VWA k59_257256_1 1000565.METUNv1_02701 1.07e-82 256.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KVSS@206389|Rhodocyclales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23,OmpA k59_439052_2 1000565.METUNv1_00905 6.61e-70 212.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,2VT2B@28216|Betaproteobacteria,2KWKJ@206389|Rhodocyclales 206389|Rhodocyclales NU pilus assembly protein PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_792631_1 1000565.METUNv1_02692 0.0 1217.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2VJMQ@28216|Betaproteobacteria,2KVQN@206389|Rhodocyclales 206389|Rhodocyclales HJ ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_653381_1 530564.Psta_3072 2.88e-82 262.0 COG0840@1|root,COG0840@2|Bacteria,2IXQA@203682|Planctomycetes 203682|Planctomycetes NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K02660,ko:K03406 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035,ko02044 - - - Globin,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9 k59_1111995_1 748247.AZKH_3168 1.31e-41 151.0 COG0145@1|root,COG0145@2|Bacteria,1R3RA@1224|Proteobacteria,2VZPU@28216|Betaproteobacteria,2KYJI@206389|Rhodocyclales 206389|Rhodocyclales J Hydantoinase/oxoprolinase N-terminal region - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1111995_2 748247.AZKH_3167 1.26e-82 245.0 COG4647@1|root,COG4647@2|Bacteria,1RD95@1224|Proteobacteria,2WBCP@28216|Betaproteobacteria,2KZ8X@206389|Rhodocyclales 206389|Rhodocyclales J Acetone carboxylase gamma subunit - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Acetone_carb_G k59_471093_1 579405.Dd703_3692 4.44e-107 321.0 COG4637@1|root,COG4938@1|root,COG4637@2|Bacteria,COG4938@2|Bacteria,1NEEG@1224|Proteobacteria,1RZMD@1236|Gammaproteobacteria 1236|Gammaproteobacteria D AAA ATPase domain - - - - - - - - - - - - AAA_15,DUF3696 k59_510299_1 485918.Cpin_2188 2.86e-28 115.0 COG0747@1|root,COG3291@1|root,COG0747@2|Bacteria,COG3291@2|Bacteria,4NJQI@976|Bacteroidetes 976|Bacteroidetes O amine dehydrogenase activity - - - - - - - - - - - - CBM_6,Crystall,PKD,PPC,Reprolysin_3,RicinB_lectin_2 k59_1081753_1 1000565.METUNv1_02583 8.05e-77 234.0 COG1278@1|root,COG3326@1|root,COG1278@2|Bacteria,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,2VQXP@28216|Betaproteobacteria,2KX2F@206389|Rhodocyclales 206389|Rhodocyclales K Protein of unknown function (DUF1294) - - - - - - - - - - - - CSD,DUF1294 k59_43039_1 1038862.KB893884_gene766 8.62e-81 248.0 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT49@28211|Alphaproteobacteria,3K65I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_188929_1 488538.SAR116_0382 1.57e-63 214.0 28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria,2U6Z0@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_510303_2 670307.HYPDE_25948 1.96e-48 159.0 COG2905@1|root,COG2905@2|Bacteria,1N1TU@1224|Proteobacteria,2VFMU@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_510303_4 1144275.COCOR_01453 4.46e-05 44.7 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,42ND0@68525|delta/epsilon subdivisions,2WNKU@28221|Deltaproteobacteria,2YTTK@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF808) - - - ko:K09781 - - - - ko00000 - - - DUF808 k59_653419_2 535289.Dtpsy_1467 2.24e-77 235.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,4AAXT@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM SNARE associated Golgi protein dedA - - ko:K03975 - - - - ko00000 - - - SNARE_assoc k59_257287_1 1198452.Jab_1c23550 1.27e-107 325.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJ7P@28216|Betaproteobacteria,4760X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_471112_1 1000565.METUNv1_03877 3.37e-56 181.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,2KUPT@206389|Rhodocyclales 206389|Rhodocyclales L exodeoxyribonuclease III - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_471112_2 864051.BurJ1DRAFT_0995 2.12e-06 48.5 COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,2WGBZ@28216|Betaproteobacteria,1KK0Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_683795_1 1000565.METUNv1_01432 4.96e-67 224.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,2KVX3@206389|Rhodocyclales 206389|Rhodocyclales P receptor - - - ko:K16090 - - - - ko00000,ko02000 1.B.14.1.11 - - Plug,TonB_dep_Rec k59_257289_2 1000565.METUNv1_02599 6.59e-63 209.0 COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VHDQ@28216|Betaproteobacteria,2KW16@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - - - - - - - - - - GGDEF,HDOD,Response_reg k59_364496_1 614083.AWQR01000017_gene2260 2.92e-139 404.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,4ABI9@80864|Comamonadaceae 28216|Betaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_364496_2 1123255.JHYS01000001_gene1894 1.75e-69 215.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,4AAKT@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_828672_1 1000565.METUNv1_02366 2.13e-123 364.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,2KV4V@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_218999_1 1353529.M899_2097 7.41e-05 44.3 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,42MUR@68525|delta/epsilon subdivisions,2MT66@213481|Bdellovibrionales,2WJC8@28221|Deltaproteobacteria 213481|Bdellovibrionales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_218999_2 1353529.M899_2097 1.92e-92 280.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,42MUR@68525|delta/epsilon subdivisions,2MT66@213481|Bdellovibrionales,2WJC8@28221|Deltaproteobacteria 213481|Bdellovibrionales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_792678_1 1000565.METUNv1_03360 1.75e-98 313.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria,2KVH0@206389|Rhodocyclales 206389|Rhodocyclales C Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_188968_1 375286.mma_2198 1.55e-74 240.0 28QU5@1|root,2ZD9H@2|Bacteria,1RAU8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_257304_1 398527.Bphyt_0330 1.66e-10 63.2 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VJ7N@28216|Betaproteobacteria,1K34X@119060|Burkholderiaceae 28216|Betaproteobacteria S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_439151_1 686578.AFFX01000005_gene4270 6.74e-109 325.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1007047_1 1000565.METUNv1_00047 4.67e-198 556.0 COG3409@1|root,COG3409@2|Bacteria,1R7JY@1224|Proteobacteria,2VY5B@28216|Betaproteobacteria 28216|Betaproteobacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - - k59_188983_1 497964.CfE428DRAFT_6644 4.65e-56 192.0 COG1657@1|root,COG1657@2|Bacteria,46TK5@74201|Verrucomicrobia 74201|Verrucomicrobia I Squalene-hopene cyclase N-terminal domain sqhC - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_6566_1 1123487.KB892865_gene1522 1.19e-28 105.0 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,2VU9E@28216|Betaproteobacteria,2KX1W@206389|Rhodocyclales 206389|Rhodocyclales S RnfH family Ubiquitin rnfH - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_6566_2 76114.ebA2585 4.42e-32 119.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,2VJ7M@28216|Betaproteobacteria,2KVHC@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_653480_1 338969.Rfer_2195 9.68e-45 145.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,4AI2T@80864|Comamonadaceae 28216|Betaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_653480_2 614083.AWQR01000031_gene2662 4.83e-84 250.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,4ADGP@80864|Comamonadaceae 28216|Betaproteobacteria J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_653480_3 614083.AWQR01000031_gene2663 1.14e-38 140.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,4A9KD@80864|Comamonadaceae 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_439162_1 1122951.ATUE01000009_gene383 3.02e-95 286.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,1RNDQ@1236|Gammaproteobacteria,3NJGZ@468|Moraxellaceae 1236|Gammaproteobacteria P CorA-like Mg2+ transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_257315_1 1502852.FG94_02961 1.34e-125 367.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,4723K@75682|Oxalobacteraceae 28216|Betaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_148793_1 365046.Rta_24710 9.64e-103 319.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,4AAGE@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_400344_1 338969.Rfer_3868 1.02e-122 384.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,4AC8V@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM pyruvate ferredoxin flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_653497_1 1000565.METUNv1_03757 5.99e-89 276.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VMAH@28216|Betaproteobacteria,2KUGS@206389|Rhodocyclales 206389|Rhodocyclales C Protein of unknown function (DUF3485) - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_720570_1 1000565.METUNv1_00416 1.11e-69 222.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2VI7R@28216|Betaproteobacteria,2KWH4@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_828720_1 1123256.KB907940_gene213 2.12e-88 274.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1X39P@135614|Xanthomonadales 135614|Xanthomonadales P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_439202_1 1000565.METUNv1_00483 2.22e-126 373.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,2KVI3@206389|Rhodocyclales 206389|Rhodocyclales S SpoVR family - - - - - - - - - - - - SpoVR k59_219027_1 765913.ThidrDRAFT_4271 1.33e-56 194.0 COG2909@1|root,COG2909@2|Bacteria,1R4DB@1224|Proteobacteria,1THR3@1236|Gammaproteobacteria,1X0D9@135613|Chromatiales 135613|Chromatiales K trisaccharide binding - - - - - - - - - - - - - k59_969487_1 1000565.METUNv1_02542 5.56e-165 471.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,2KU8B@206389|Rhodocyclales 206389|Rhodocyclales M mechanosensitive - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_828728_1 981336.F944_00128 1.61e-18 77.8 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,3NNXA@468|Moraxellaceae 1236|Gammaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_828728_2 1120977.JHUX01000005_gene2854 8.03e-79 241.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,3NK9Q@468|Moraxellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1112070_1 1198452.Jab_2c05730 8.91e-26 102.0 COG4709@1|root,COG4709@2|Bacteria,1PXNB@1224|Proteobacteria,2WD1B@28216|Betaproteobacteria,476K5@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1700) - - - - - - - - - - - - DUF1700 k59_1112070_2 1198452.Jab_2c05720 5.37e-34 125.0 COG3595@1|root,COG3595@2|Bacteria,1N8NB@1224|Proteobacteria,2VS2U@28216|Betaproteobacteria,475UR@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_293672_1 929556.Solca_2599 5.47e-38 137.0 COG0077@1|root,COG0077@2|Bacteria,4NEEK@976|Bacteroidetes,1IQJU@117747|Sphingobacteriia 976|Bacteroidetes E Prephenate dehydratase pheA - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - PDT k59_510427_1 1000565.METUNv1_02256 4.02e-49 173.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_510427_2 1123487.KB892855_gene2563 2.16e-12 62.8 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2VSG7@28216|Betaproteobacteria,2KWTF@206389|Rhodocyclales 206389|Rhodocyclales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_721307_1 640081.Dsui_0127 2.78e-36 131.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,2KUMZ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_365512_2 1000565.METUNv1_01199 4.63e-67 207.0 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,2VX03@28216|Betaproteobacteria,2KX5V@206389|Rhodocyclales 206389|Rhodocyclales NU Prokaryotic N-terminal methylation motif - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_793664_1 392499.Swit_4443 6.66e-73 246.0 COG3170@1|root,COG3170@2|Bacteria,1QVEE@1224|Proteobacteria,2TWDG@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_1043140_1 1000565.METUNv1_01657 2.01e-192 545.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VHFE@28216|Betaproteobacteria,2KVID@206389|Rhodocyclales 206389|Rhodocyclales P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC k59_1112760_1 1000565.METUNv1_01859 2.22e-304 849.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_149787_1 1000565.METUNv1_03837 1.24e-137 401.0 COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_149787_2 1000565.METUNv1_03836 1.62e-141 407.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,2VN04@28216|Betaproteobacteria,2KVG5@206389|Rhodocyclales 206389|Rhodocyclales G Fructosamine kinase - - - - - - - - - - - - Fructosamin_kin k59_149787_3 1000565.METUNv1_03835 2.58e-44 148.0 COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,2KW96@206389|Rhodocyclales 206389|Rhodocyclales S Phasin protein - - - - - - - - - - - - Phasin_2 k59_901187_1 358220.C380_06700 3.76e-131 384.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,4A9RX@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM AAA ATPase central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_611894_1 1000565.METUNv1_00349 1.31e-71 222.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,2VQRP@28216|Betaproteobacteria,2KW80@206389|Rhodocyclales 206389|Rhodocyclales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos k59_611894_3 1000565.METUNv1_00345 3.73e-15 74.3 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,2KVH6@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_258239_1 296591.Bpro_4192 1.24e-18 80.5 COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2VSPA@28216|Betaproteobacteria,4ADZT@80864|Comamonadaceae 28216|Betaproteobacteria K Transcription regulator MerR DNA binding zntR - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_258239_2 614083.AWQR01000006_gene273 4.61e-30 110.0 COG2050@1|root,COG2050@2|Bacteria,1MYE0@1224|Proteobacteria,2WFMX@28216|Betaproteobacteria,4AEDY@80864|Comamonadaceae 28216|Betaproteobacteria Q Domain of unknown function (DUF4442) - - - - - - - - - - - - 4HBT k59_440718_1 517418.Ctha_2612 1.98e-74 250.0 28JCN@1|root,2Z978@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_472037_1 29581.BW37_01849 8.31e-62 194.0 COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,2VT3J@28216|Betaproteobacteria,474JG@75682|Oxalobacteraceae 28216|Betaproteobacteria S PRC-barrel domain - - - - - - - - - - - - PRC k59_472037_2 1276756.AUEX01000001_gene881 1.47e-15 75.5 COG1055@1|root,COG1055@2|Bacteria,1N68M@1224|Proteobacteria,2VH3A@28216|Betaproteobacteria,4AC51@80864|Comamonadaceae 28216|Betaproteobacteria P Putative Na+/H+ antiporter - - - - - - - - - - - - Na_H_antiport_3 k59_43990_1 925409.KI911562_gene2773 6.42e-47 159.0 COG0697@1|root,COG0697@2|Bacteria,4NH9M@976|Bacteroidetes,1ISD3@117747|Sphingobacteriia 976|Bacteroidetes EG PFAM EamA-like transporter family - - - - - - - - - - - - EamA k59_43990_2 1450525.JATV01000018_gene2433 1.31e-38 139.0 COG1820@1|root,COG1820@2|Bacteria,4NJ35@976|Bacteroidetes,1I1UK@117743|Flavobacteriia,2NSFZ@237|Flavobacterium 976|Bacteroidetes G Belongs to the metallo-dependent hydrolases superfamily. NagA family - - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_219539_1 1458275.AZ34_15300 1.04e-42 150.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4AAFI@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_219539_2 1504672.669784136 1.25e-47 163.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,4AB16@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_970126_1 1276756.AUEX01000001_gene990 3.97e-110 329.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,4AAVV@80864|Comamonadaceae 28216|Betaproteobacteria S CBS domain containing protein - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_401039_1 795666.MW7_1817 2.55e-08 55.8 2CDW1@1|root,330WG@2|Bacteria,1NBGA@1224|Proteobacteria,2VWA8@28216|Betaproteobacteria,1K9W4@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1043162_1 614083.AWQR01000039_gene1491 5.88e-106 326.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,4AD1X@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - DUF3365,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg,dCache_1 k59_942785_2 388413.ALPR1_19903 1.32e-41 148.0 COG0624@1|root,COG0624@2|Bacteria,4NI66@976|Bacteroidetes,47NB9@768503|Cytophagia 976|Bacteroidetes E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1056098_1 535289.Dtpsy_3238 8.72e-22 92.0 28K7Y@1|root,2Z9VX@2|Bacteria,1QFIB@1224|Proteobacteria,2VJ3E@28216|Betaproteobacteria,4ABYE@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1056098_2 596153.Alide_0470 2.22e-71 225.0 2DB8P@1|root,2Z7SB@2|Bacteria,1R765@1224|Proteobacteria,2VN78@28216|Betaproteobacteria,4AD0F@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_482934_2 1124991.MU9_702 0.00054 43.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1224|Proteobacteria NT chemotaxis, protein - - - ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,MCPsignal k59_376831_2 29581.BW37_05310 2.66e-32 120.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,4747S@75682|Oxalobacteraceae 28216|Betaproteobacteria K Cyclic nucleotide-monophosphate binding domain dnrD - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_979924_1 1000565.METUNv1_03790 3.69e-163 466.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,2KV1D@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_160782_1 1000565.METUNv1_01310 0.000487 42.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,2KUS0@206389|Rhodocyclales 206389|Rhodocyclales M UTP-glucose-1-phosphate uridylyltransferase epsT - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_160782_2 1000565.METUNv1_01309 5.99e-109 315.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,2KVMU@206389|Rhodocyclales 206389|Rhodocyclales F phosphoribosyltransferase - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_160782_3 1000565.METUNv1_01308 1.74e-91 270.0 COG0847@1|root,COG0847@2|Bacteria,1RHD8@1224|Proteobacteria,2VSET@28216|Betaproteobacteria,2KZ2K@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - - - - - - - - - - - - k59_1056117_1 397945.Aave_2355 3.02e-75 249.0 COG3170@1|root,COG3170@2|Bacteria,1N4R0@1224|Proteobacteria,2VPR6@28216|Betaproteobacteria,4AIY2@80864|Comamonadaceae 28216|Betaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - P22_portal k59_942807_1 1144342.PMI40_02897 2.69e-94 281.0 COG4790@1|root,COG4790@2|Bacteria,1R34E@1224|Proteobacteria,2VQWC@28216|Betaproteobacteria,474HC@75682|Oxalobacteraceae 28216|Betaproteobacteria U TIGRFAM type III secretion apparatus protein, YscR HrcR family bscR - - ko:K03226 ko03070,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko02044 3.A.6.1,3.A.6.3 - - FliP k59_671791_1 159087.Daro_1073 6.57e-10 58.9 COG2267@1|root,COG2267@2|Bacteria,1QVBZ@1224|Proteobacteria,2VNI1@28216|Betaproteobacteria 28216|Betaproteobacteria I Alpha beta hydrolase - - 1.11.1.10 ko:K00433 - - - - ko00000,ko01000 - - - Abhydrolase_6 k59_671791_2 1000565.METUNv1_00101 2.17e-20 92.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_910092_1 522306.CAP2UW1_4465 2.25e-72 224.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2W8Y3@28216|Betaproteobacteria,1KQ24@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_671802_1 795666.MW7_1013 2.2e-160 461.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VHAI@28216|Betaproteobacteria,1KFM6@119060|Burkholderiaceae 28216|Betaproteobacteria L helicase superfamily c-terminal domain - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_764626_3 1042209.HK44_023830 1.42e-09 58.2 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1YSS1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family intA - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_1056164_1 688245.CtCNB1_1596 2.25e-90 287.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4ACW2@80864|Comamonadaceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase hcrA - 1.3.7.9 ko:K04108 ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220 - R05316 RC00490 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_585640_1 391624.OIHEL45_17056 6.73e-11 69.3 COG0500@1|root,COG0726@1|root,COG1215@1|root,COG0500@2|Bacteria,COG0726@2|Bacteria,COG1215@2|Bacteria,1R7PS@1224|Proteobacteria,2TU1B@28211|Alphaproteobacteria 28211|Alphaproteobacteria GMQ Polysaccharide deacetylase - - - - - - - - - - - - Glycos_transf_2,NodS,Polysacc_deac_1 k59_804672_1 1123487.KB892834_gene2739 2.19e-70 228.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,2KZQ0@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_88932_1 1114972.AUAW01000004_gene336 6.49e-13 72.8 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H9Y8@91061|Bacilli,3F4MW@33958|Lactobacillaceae 91061|Bacilli L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_306542_1 648757.Rvan_1474 1.59e-81 259.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2V8QM@28211|Alphaproteobacteria,3N8M3@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L helicase superfamily c-terminal domain - - - - - - - - - - - - Helicase_C,ResIII k59_306542_2 1572715.A0A0A7TWE4_9CAUD 3.59e-07 53.9 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_306542_5 1121271.AUCM01000021_gene2787 5.33e-05 47.0 29NSD@1|root,309QE@2|Bacteria,1RF5V@1224|Proteobacteria,2U81M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM VRR-NUC domain protein - - - - - - - - - - - - - k59_979970_1 1121033.AUCF01000013_gene1573 5.02e-69 216.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2TTHN@28211|Alphaproteobacteria,2JS6Y@204441|Rhodospirillales 204441|Rhodospirillales N Flagellar biosynthetic protein FliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_457278_1 1267211.KI669560_gene1030 1.86e-90 274.0 COG0524@1|root,COG0524@2|Bacteria,4NH9X@976|Bacteroidetes,1IUE3@117747|Sphingobacteriia 976|Bacteroidetes G pfkB family carbohydrate kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_585663_1 543728.Vapar_1839 1.77e-132 400.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,4AAPA@80864|Comamonadaceae 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_979994_1 375286.mma_2775 5.39e-108 315.0 2DBUA@1|root,2ZB4Z@2|Bacteria,1PB9S@1224|Proteobacteria,2VM25@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_54116_1 118166.JH976537_gene4474 3.97e-09 57.8 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1G5IK@1117|Cyanobacteria,1HEEQ@1150|Oscillatoriales 1117|Cyanobacteria C Dehydrogenase E1 component - - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_54116_2 330214.NIDE2328 9.54e-38 135.0 COG2605@1|root,COG2605@2|Bacteria 2|Bacteria G GHMP kinase lmbP - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_528665_1 398578.Daci_1959 3.25e-70 233.0 COG4678@1|root,COG4678@2|Bacteria 2|Bacteria - - traG - - ko:K12056 - - - - ko00000,ko02044 3.A.7.11.1 - - TraG_N k59_585672_1 509635.N824_28135 7.78e-10 58.9 COG3832@1|root,COG3832@2|Bacteria,4NRGI@976|Bacteroidetes,1ITIV@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_585672_2 342113.DM82_6093 3.58e-19 82.4 COG3832@1|root,COG3832@2|Bacteria,1RF9V@1224|Proteobacteria,2VZDA@28216|Betaproteobacteria,1K7R5@119060|Burkholderiaceae 28216|Betaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_694629_1 311402.Avi_0792 4.63e-08 55.8 COG3493@1|root,COG3493@2|Bacteria,1NKCA@1224|Proteobacteria,2TUQ0@28211|Alphaproteobacteria,4BJ4G@82115|Rhizobiaceae 28211|Alphaproteobacteria C 2-hydroxycarboxylate transporter family - - - - - - - - - - - - 2HCT k59_694629_2 1538295.JY96_02565 1.21e-13 69.3 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1KJJG@119065|unclassified Burkholderiales 28216|Betaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_553045_1 1072685.IX83_07100 2.38e-16 80.9 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,2VU8A@28216|Betaproteobacteria,3T6RG@506|Alcaligenaceae 28216|Betaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_376926_1 159087.Daro_0683 7.59e-94 286.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria,2KXRJ@206389|Rhodocyclales 206389|Rhodocyclales P Citrate transporter - - - - - - - - - - - - CitMHS k59_1122177_1 1157708.KB907462_gene966 8.94e-79 235.0 COG0346@1|root,COG0346@2|Bacteria,1RD12@1224|Proteobacteria,2VRQ0@28216|Betaproteobacteria,4AHZN@80864|Comamonadaceae 28216|Betaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase,Glyoxalase_4 k59_1122177_2 1286631.X805_33340 1.31e-14 69.7 COG2030@1|root,COG2030@2|Bacteria,1RC6U@1224|Proteobacteria,2VQU2@28216|Betaproteobacteria 28216|Betaproteobacteria I PFAM MaoC domain protein dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_671920_1 1121870.AUAA01000048_gene2093 1.35e-27 105.0 COG3832@1|root,COG3832@2|Bacteria,4NQ4A@976|Bacteroidetes,1I391@117743|Flavobacteriia,3HI6W@358033|Chryseobacterium 976|Bacteroidetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_671920_2 983544.Lacal_2695 6.21e-22 94.4 COG1418@1|root,COG1418@2|Bacteria,4NE3V@976|Bacteroidetes,1HYHI@117743|Flavobacteriia 976|Bacteroidetes J Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_483073_1 595537.Varpa_4759 8.52e-110 330.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,4AA3F@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_553080_1 1227276.HMPREF9148_01728 4.13e-16 83.6 COG0675@1|root,COG0675@2|Bacteria,4PJXW@976|Bacteroidetes,2FTB4@200643|Bacteroidia 976|Bacteroidetes L Putative transposase DNA-binding domain - - - - - - - - - - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_671961_1 640081.Dsui_0348 4.99e-50 160.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KWPF@206389|Rhodocyclales 206389|Rhodocyclales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_483092_1 1121015.N789_06760 1.54e-35 129.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1XAYP@135614|Xanthomonadales 135614|Xanthomonadales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_483092_2 1267005.KB911256_gene1869 2.67e-11 63.2 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3N65M@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component dctM GO:0005575,GO:0016020,GO:0016021,GO:0031224,GO:0044425 - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM,DctQ k59_1122213_1 1034101.G1D1G4_9CAUD 3.45e-62 205.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_228292_1 1000565.METUNv1_03869 1.65e-139 406.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KU74@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_376981_1 1198452.Jab_2c29500 1.02e-61 204.0 COG4242@1|root,COG4242@2|Bacteria,1R6CH@1224|Proteobacteria,2W0XB@28216|Betaproteobacteria,475SV@75682|Oxalobacteraceae 28216|Betaproteobacteria M Peptidase family S51 cphE4 - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_228298_1 948106.AWZT01000063_gene4075 1.38e-54 183.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VVNG@28216|Betaproteobacteria,1K21M@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_694695_1 1000565.METUNv1_02736 9.34e-70 230.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria,2KV82@206389|Rhodocyclales 206389|Rhodocyclales S Protein conserved in bacteria - - - - - - - - - - - - - k59_54202_2 76114.ebA5763 1.29e-37 141.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KVRF@206389|Rhodocyclales 206389|Rhodocyclales S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_89049_1 76114.ebA6478 4.34e-34 132.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria,2KXZ8@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_409677_1 614083.AWQR01000019_gene3797 4.08e-80 266.0 2DBMY@1|root,2ZA0V@2|Bacteria,1QXJ4@1224|Proteobacteria,2VN17@28216|Betaproteobacteria,4AAH7@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of Unknown Function (DUF349) - - - - - - - - - - - - DUF349 k59_731293_1 32057.KB217478_gene1794 0.00025 44.7 COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1HIN7@1161|Nostocales 1117|Cyanobacteria T response regulator, receiver - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_731293_2 1120999.JONM01000007_gene1743 5.93e-09 57.4 COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,2KSJN@206351|Neisseriales 206351|Neisseriales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,TPR_12 k59_228323_1 1458275.AZ34_11730 7.61e-112 347.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,4AAP4@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_17877_1 580332.Slit_1655 2.12e-21 99.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,44W4C@713636|Nitrosomonadales 28216|Betaproteobacteria S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_17877_2 1000565.METUNv1_00921 6.66e-94 286.0 COG2200@1|root,COG2200@2|Bacteria,1PDZY@1224|Proteobacteria,2VM72@28216|Betaproteobacteria,2KURH@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL k59_674116_1 1163617.SCD_n00051 3.71e-53 186.0 COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,2VIF1@28216|Betaproteobacteria 28216|Betaproteobacteria C acetyl-CoA hydrolase - - - ko:K18288 ko00660,map00660 - R02407,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_90460_1 365044.Pnap_0802 3.21e-18 84.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,4A9RF@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_90460_2 365044.Pnap_0801 2.7e-73 229.0 COG0559@1|root,COG0559@2|Bacteria,1MXMC@1224|Proteobacteria,2VJ1Y@28216|Betaproteobacteria,4AASW@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_90463_1 29581.BW37_02074 6.37e-49 164.0 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VNHF@28216|Betaproteobacteria,472K0@75682|Oxalobacteraceae 28216|Betaproteobacteria H Tetrapyrrole (Corrin/Porphyrin) Methylases cysG - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase k59_1019093_1 1396141.BATP01000003_gene5276 1.16e-57 192.0 COG0477@1|root,COG2814@2|Bacteria,46U6X@74201|Verrucomicrobia,2IV79@203494|Verrucomicrobiae 203494|Verrucomicrobiae EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_410822_1 1445613.JALM01000162_gene2557 1.09e-48 172.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,4E02B@85010|Pseudonocardiales 201174|Actinobacteria P Flavin-binding monooxygenase-like ptlE GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0044237,GO:0044249,GO:0046483,GO:0055114,GO:0071704,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901576 1.14.13.170,1.14.13.171,1.14.13.22 ko:K03379,ko:K18091 ko00930,ko01120,ko01130,ko01220,map00930,map01120,map01130,map01220 M00819 R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko00002,ko01000 - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_554661_1 1000565.METUNv1_01434 2.51e-35 133.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,2KUWB@206389|Rhodocyclales 206389|Rhodocyclales C FAD linked oxidase - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_554661_2 1286631.X805_09570 1.67e-63 201.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2VJHT@28216|Betaproteobacteria,1KKG8@119065|unclassified Burkholderiales 28216|Betaproteobacteria C oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ybiX - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_695917_1 1000565.METUNv1_02766 2.38e-143 417.0 2BGDI@1|root,32ABA@2|Bacteria,1RKWG@1224|Proteobacteria,2VYJE@28216|Betaproteobacteria,2KZ24@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_282141_1 1000565.METUNv1_02667 2.77e-148 427.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,2KV9G@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_706854_1 696747.NIES39_J01250 4.12e-26 110.0 COG0517@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG0517@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria,1H9RR@1150|Oscillatoriales 1117|Cyanobacteria T diguanylate cyclase - - - - - - - - - - - - CBS,GAF,GAF_2,GAF_3,GGDEF,PAS_3,PAS_9 k59_992219_1 903818.KI912269_gene485 9.51e-48 154.0 COG1534@1|root,COG1534@2|Bacteria 2|Bacteria J preribosome binding yhbY GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_992219_2 56110.Oscil6304_2576 2.22e-07 53.9 COG0515@1|root,COG2203@1|root,COG2208@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain pkn5 - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg,SpoIIE k59_174161_1 543913.D521_1541 2.67e-50 166.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,1KQ7H@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_174161_2 543913.D521_1540 3.72e-18 77.0 COG3114@1|root,COG3114@2|Bacteria 2|Bacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmD GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735 CcmD k59_174161_3 312153.Pnuc_1514 2.03e-33 119.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1K8MK@119060|Burkholderiaceae 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_596659_1 1123367.C666_08960 1.07e-257 718.0 COG1061@1|root,COG1061@2|Bacteria,1PPY3@1224|Proteobacteria 1224|Proteobacteria L type III restriction enzyme, res subunit - - - - - - - - - - - - ERCC3_RAD25_C,Helicase_C,PLDc_2,ResIII k59_921567_1 1223521.BBJX01000011_gene8 5.19e-119 345.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,4AAY0@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM Serine O-acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_567278_1 596154.Alide2_4457 6.91e-76 240.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,4ABFQ@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_628980_1 1121127.JAFA01000033_gene4547 4.81e-80 250.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,1K5JW@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM NnrS family protein - - - ko:K07234 - - - - ko00000 - - - NnrS k59_137377_1 1454007.JAUG01000040_gene111 4.99e-33 122.0 2DBEP@1|root,2Z8SY@2|Bacteria,4NKR9@976|Bacteroidetes,1IUCX@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_921578_2 1288494.EBAPG3_16100 2.46e-74 224.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2VQ31@28216|Betaproteobacteria,37304@32003|Nitrosomonadales 28216|Betaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_282182_1 365046.Rta_06640 1.18e-57 185.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,2VRVF@28216|Betaproteobacteria,4AE77@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_282182_2 1223521.BBJX01000006_gene1605 7.95e-25 102.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,4ABER@80864|Comamonadaceae 28216|Betaproteobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding accA1 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_103013_1 596154.Alide2_0761 2.25e-93 273.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,4ADIX@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM OsmC family protein yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_241098_2 1250005.PHEL85_1279 1.09e-14 72.0 COG3797@1|root,COG3797@2|Bacteria,4NSKS@976|Bacteroidetes,1I28Y@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - DUF1697 k59_746364_1 56780.SYN_02283 7.27e-20 93.2 COG4675@1|root,COG4675@2|Bacteria,1N2XN@1224|Proteobacteria 1224|Proteobacteria S tail collar domain protein - - - - - - - - - - - - - k59_105146_1 1209072.ALBT01000058_gene830 1.1e-25 110.0 COG3300@1|root,COG5002@1|root,COG3300@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_923351_1 204773.HEAR3147 1.17e-83 248.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2VRAK@28216|Betaproteobacteria,474BD@75682|Oxalobacteraceae 28216|Betaproteobacteria J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_31920_1 765911.Thivi_1720 3.39e-39 149.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3279@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3279@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2TI@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_139216_1 946483.Cenrod_0803 3.98e-93 304.0 COG1353@1|root,COG1353@2|Bacteria,1NB2Y@1224|Proteobacteria,2VZCE@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM CRISPR-associated protein Csm1 - - - ko:K07016 - - - - ko00000,ko02048 - - - - k59_31923_1 1538295.JY96_10375 1.21e-120 358.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1KJBV@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Aldehyde dehydrogenase family puuC - 1.2.1.54,1.2.1.8,1.2.1.99 ko:K00130,ko:K09472,ko:K12254 ko00260,ko00330,ko01100,map00260,map00330,map01100 M00136,M00555 R02549,R02565,R02566,R03177,R07417,R07418 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1102508_1 1000565.METUNv1_01364 4.72e-116 361.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KURD@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07239 - - - - ko00000 2.A.6.1 - - ACR_tran k59_423074_1 1070319.CAGGBEG34_160003 2.04e-62 211.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1K30A@119060|Burkholderiaceae 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_283762_1 1121035.AUCH01000009_gene849 1.86e-48 164.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,2KVQ9@206389|Rhodocyclales 206389|Rhodocyclales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_283762_2 522306.CAP2UW1_0792 6.75e-20 87.8 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria 28216|Betaproteobacteria H synthase hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_176408_1 925409.KI911562_gene2120 1.25e-90 280.0 COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,1INMG@117747|Sphingobacteriia 976|Bacteroidetes E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_777807_1 365046.Rta_27870 1.63e-26 99.8 COG0454@1|root,COG0456@2|Bacteria,1N7JM@1224|Proteobacteria,2VU1F@28216|Betaproteobacteria,4AEBG@80864|Comamonadaceae 28216|Betaproteobacteria K Protein of unknown function (DUF3579) - - - - - - - - - - - - DUF3579 k59_777807_2 296591.Bpro_3572 2.86e-40 143.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,4A9QQ@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM acetylornithine and succinylornithine argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1034202_1 316274.Haur_2724 3.19e-16 77.8 COG0526@1|root,COG0526@2|Bacteria,2G737@200795|Chloroflexi,375V3@32061|Chloroflexia 32061|Chloroflexia CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,DnaJ k59_746474_1 938709.AUSH02000051_gene205 4.08e-112 342.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_598520_1 614083.AWQR01000005_gene1010 6.46e-77 238.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,4A9KE@80864|Comamonadaceae 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_708784_1 1008459.TASI_0412 8.32e-47 164.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,3T3XF@506|Alcaligenaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_994078_1 267608.RSp1594 2.35e-71 229.0 COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,2VKYN@28216|Betaproteobacteria,1K0W7@119060|Burkholderiaceae 28216|Betaproteobacteria M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Porin_4 k59_423113_1 83406.HDN1F_29280 1.35e-39 144.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1J54S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_105252_1 1237149.C900_00706 8.72e-43 159.0 COG0323@1|root,COG0323@2|Bacteria,4NDWJ@976|Bacteroidetes,47KZU@768503|Cytophagia 976|Bacteroidetes L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_176487_2 1000565.METUNv1_00570 4.63e-153 433.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,2KUVF@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1137083_1 5786.XP_003283797.1 0.000337 47.8 299UC@1|root,2RGWP@2759|Eukaryota,3XGGD@554915|Amoebozoa 554915|Amoebozoa U Pleckstrin homology domain. - - - - - - - - - - - - PH k59_746550_1 1005048.CFU_0147 2.03e-64 204.0 COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,2VQER@28216|Betaproteobacteria,474MD@75682|Oxalobacteraceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain gst3 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_746550_2 1149133.ppKF707_2348 1.68e-06 50.1 COG1018@1|root,COG3576@1|root,COG1018@2|Bacteria,COG3576@2|Bacteria,1MV41@1224|Proteobacteria,1RMPJ@1236|Gammaproteobacteria,1YCRF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - FAD_binding_6,Fer2,NAD_binding_1,Putative_PNPOx k59_105306_1 1121035.AUCH01000005_gene214 8.76e-111 331.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,2KUVT@206389|Rhodocyclales 206389|Rhodocyclales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_923484_1 887062.HGR_06926 1.53e-105 331.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2VHPF@28216|Betaproteobacteria,4AB26@80864|Comamonadaceae 28216|Betaproteobacteria M Bacterial cellulose synthase subunit - - - ko:K20541 - - - - ko00000,ko02000 4.D.3.1.6 - - BcsB k59_68442_1 1294143.H681_01775 3.97e-76 251.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E GTPases (dynamin-related) - - - - - - - - - - - - Dynamin_N k59_283921_2 375286.mma_2193 4.01e-15 77.4 COG4678@1|root,COG4678@2|Bacteria 2|Bacteria - - - - - ko:K12056 - - - - ko00000,ko02044 3.A.7.11.1 - - - k59_139385_1 666684.AfiDRAFT_3222 6.82e-32 125.0 COG3300@1|root,COG5001@1|root,COG3300@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JT1X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Bacterial signalling protein N terminal repeat - - - - - - - - - - - - EAL,GGDEF,MHYT,PAS_7,PAS_8 k59_994215_1 1349767.GJA_2681 1.16e-126 389.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,476TQ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_746650_1 1117958.PE143B_0129720 2.07e-88 275.0 2DUCN@1|root,33PZW@2|Bacteria,1NTHY@1224|Proteobacteria 1224|Proteobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_32150_1 1149133.ppKF707_0729 1.28e-85 264.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1YD9R@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Transcriptional regulator finR - - - - - - - - - - - HTH_1,LysR_substrate k59_630459_1 658187.LDG_6735 6.89e-48 164.0 COG0463@1|root,COG0463@2|Bacteria,1R6J7@1224|Proteobacteria,1SKX5@1236|Gammaproteobacteria,1JGMN@118969|Legionellales 118969|Legionellales M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_955576_2 1196322.A370_05687 5.41e-12 68.6 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,36DUG@31979|Clostridiaceae 186801|Clostridia E Belongs to the DegT DnrJ EryC1 family degT2 - - - - - - - - - - - DegT_DnrJ_EryC1 k59_778033_1 1276756.AUEX01000014_gene2881 6.89e-53 172.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,4AA53@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_778033_2 572477.Alvin_1725 9.83e-05 44.7 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria,1WYNC@135613|Chromatiales 135613|Chromatiales T PFAM Anti sigma-E protein RseA - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_1102684_1 1439940.BAY1663_04697 3.98e-62 201.0 COG4564@1|root,COG4564@2|Bacteria,1N7NM@1224|Proteobacteria,1S4HZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T PFAM Cache - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - sCache_2 k59_569527_1 1121033.AUCF01000001_gene1916 1.26e-30 112.0 2DNH0@1|root,32XFP@2|Bacteria,1N4P7@1224|Proteobacteria,2UE5N@28211|Alphaproteobacteria,2JTGU@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_569527_2 1207063.P24_13890 1.68e-15 77.8 COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,2TQKW@28211|Alphaproteobacteria,2JPHG@204441|Rhodospirillales 204441|Rhodospirillales EGP the major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1034437_1 1276756.AUEX01000001_gene991 6.81e-71 223.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,4AB5I@80864|Comamonadaceae 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_1137221_1 272621.LBA0986 7.62e-20 87.4 COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,4HA4J@91061|Bacilli,3F3KT@33958|Lactobacillaceae 91061|Bacilli G Aldose 1-epimerase lacX - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_1137221_2 927658.AJUM01000047_gene2906 3.91e-50 175.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia,3XKNN@558415|Marinilabiliaceae 976|Bacteroidetes E Formiminotransferase domain, N-terminal subdomain ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N k59_746710_1 497321.C664_18312 1.62e-121 358.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,2KUZ4@206389|Rhodocyclales 206389|Rhodocyclales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_105465_1 595537.Varpa_4959 8.79e-31 116.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,4A9K1@80864|Comamonadaceae 28216|Betaproteobacteria KLT Serine threonine protein kinase spkD - - - - - - - - - - - Pkinase k59_105465_2 1157708.KB907458_gene1709 1.51e-32 122.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,4AAC5@80864|Comamonadaceae 28216|Betaproteobacteria S domain protein yicC - - - - - - - - - - - DUF1732,YicC_N k59_709005_1 748247.AZKH_3429 4.41e-08 52.8 COG3437@1|root,COG3437@2|Bacteria,1RDJ3@1224|Proteobacteria,2VR5G@28216|Betaproteobacteria,2KWE0@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_709005_2 1454004.AW11_00360 4.18e-80 261.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,1KPSW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_709014_1 1123393.KB891316_gene1605 4.27e-24 95.5 COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,1KT32@119069|Hydrogenophilales 119069|Hydrogenophilales O Hsp20/alpha crystallin family - - - - - - - - - - - - HSP20 k59_139510_1 1000565.METUNv1_03165 7.93e-25 107.0 COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria,2VIMA@28216|Betaproteobacteria,2KWM3@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_32237_1 558884.JRGM01000035_gene3648 1.75e-11 63.9 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1Y5JV@135624|Aeromonadales 135624|Aeromonadales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_32237_2 1122951.ATUE01000008_gene283 1.94e-18 77.8 COG3197@1|root,COG3197@2|Bacteria,1QSIR@1224|Proteobacteria,1RW09@1236|Gammaproteobacteria,3NQBI@468|Moraxellaceae 1236|Gammaproteobacteria P Cytochrome oxidase maturation protein cbb3-type - - - - - - - - - - - - FixS k59_32237_3 420662.Mpe_A2479 6.64e-16 77.8 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,1KJDU@119065|unclassified Burkholderiales 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_955662_1 1313421.JHBV01000016_gene5714 1.13e-18 85.5 COG0608@1|root,COG0608@2|Bacteria,4NDW1@976|Bacteroidetes,1IQ3R@117747|Sphingobacteriia 976|Bacteroidetes L TIGRFAM single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_955662_2 1123248.KB893348_gene244 2.66e-57 187.0 COG0142@1|root,COG0142@2|Bacteria,4NET2@976|Bacteroidetes,1INM5@117747|Sphingobacteriia 976|Bacteroidetes H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_598782_2 481448.Minf_0359 5.71e-44 149.0 COG0417@1|root,COG0417@2|Bacteria,46SS2@74201|Verrucomicrobia,37GNT@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia L RNase_H superfamily - - - ko:K06877 - - - - ko00000 - - - RNase_H_2 k59_105536_1 107636.JQNK01000008_gene3840 1.03e-59 197.0 COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,2TU81@28211|Alphaproteobacteria,36Z62@31993|Methylocystaceae 28211|Alphaproteobacteria M Polysaccharide biosynthesis protein rfbG - 4.2.1.45 ko:K01709 ko00520,map00520 - R02426 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_778154_1 1095769.CAHF01000014_gene2886 1.23e-35 126.0 2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,2VUU0@28216|Betaproteobacteria,478TP@75682|Oxalobacteraceae 28216|Betaproteobacteria S CNP1-like family - - - - - - - - - - - - CNP1 k59_778154_2 1502852.FG94_02501 8.99e-46 158.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,473JX@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_217832_1 1000565.METUNv1_01062 3.83e-35 128.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,2KVVE@206389|Rhodocyclales 206389|Rhodocyclales S Cobalamin synthesis protein cobW C-terminal domain - - - - - - - - - - - - CobW_C,cobW k59_217832_2 1000565.METUNv1_01061 3.64e-22 86.3 COG2879@1|root,COG2879@2|Bacteria,1N6TY@1224|Proteobacteria,2VW22@28216|Betaproteobacteria,2KXG8@206389|Rhodocyclales 206389|Rhodocyclales S Selenoprotein, putative - - - - - - - - - - - - Sel_put k59_575149_1 172045.KS04_12230 2.86e-28 110.0 COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes,1HZ20@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_575149_2 485918.Cpin_1919 7.47e-43 148.0 COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes,1IPAA@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_932026_1 397945.Aave_1238 2e-79 249.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,4A9SN@80864|Comamonadaceae 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_932026_2 296591.Bpro_2190 3.49e-07 50.4 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,4A9SN@80864|Comamonadaceae 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_291483_1 929556.Solca_0687 1.24e-113 340.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,1J0YT@117747|Sphingobacteriia 976|Bacteroidetes I Biotin carboxylase C-terminal domain accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_650291_2 342113.DM82_2646 8.16e-56 177.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,1K5S0@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_718961_1 504472.Slin_2647 3.93e-66 212.0 COG4975@1|root,COG4975@2|Bacteria,4NF22@976|Bacteroidetes,47JEJ@768503|Cytophagia 976|Bacteroidetes G Sugar transport protein glcU - - ko:K05340 - - - - ko00000,ko02000 2.A.7.5 - - Ureide_permease k59_507345_2 358220.C380_09000 2.52e-60 186.0 COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,2VTYA@28216|Betaproteobacteria,4AEEH@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF962) - - - - - - - - - - - - DUF962 k59_932037_1 322710.Avin_42100 2.43e-33 126.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases - - 1.17.1.1 ko:K00523,ko:K05784 ko00362,ko00364,ko00520,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00520,map00622,map01100,map01120,map01220 M00551 R03391,R03392,R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110 RC00230,RC00270,RC01378,RC01450,RC01910 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_932037_2 533247.CRD_02110 4.25e-37 130.0 COG1208@1|root,COG1208@2|Bacteria,1G00Y@1117|Cyanobacteria,1HIZY@1161|Nostocales 1117|Cyanobacteria JM TIGRFAM Glucose-1-phosphate cytidylyltransferase rfbF - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_575156_1 1417296.U879_11600 3.83e-25 117.0 COG0642@1|root,COG2202@1|root,COG4251@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - 2.7.13.3 ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg k59_4820_1 1000565.METUNv1_00392 1.2e-93 276.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,2KUVB@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1078657_1 1123248.KB893381_gene1099 7.25e-48 167.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,1IPIQ@117747|Sphingobacteriia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_398649_1 1387312.BAUS01000002_gene352 1.2e-56 198.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VMX1@28216|Betaproteobacteria,2KNNS@206350|Nitrosomonadales 206350|Nitrosomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_398649_2 1437448.AZRT01000037_gene3063 9.99e-16 78.2 COG2847@1|root,COG4549@1|root,COG2847@2|Bacteria,COG4549@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,1J29R@118882|Brucellaceae 28211|Alphaproteobacteria S Domain of unkown function (DUF1775) - - - ko:K09796 - - - - ko00000,ko03110 - - - DUF1775,PCuAC k59_1004491_1 1217710.F969_02865 3.22e-36 137.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,3NJS6@468|Moraxellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_185965_1 580332.Slit_2013 1.07e-46 172.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44W6A@713636|Nitrosomonadales 28216|Betaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9,Phosphonate-bd,dCache_1 k59_436007_1 864051.BurJ1DRAFT_4652 3.44e-132 400.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1KK29@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_362556_1 1000565.METUNv1_02791 3.21e-98 293.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,2KUKA@206389|Rhodocyclales 206389|Rhodocyclales P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_436018_1 1175306.GWL_18940 2.61e-126 377.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,473W9@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family cyoB - 1.10.3.10 ko:K02298 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX1 k59_718988_1 1000565.METUNv1_02089 4.56e-182 517.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,2KUWI@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_147093_2 700598.Niako_4483 0.000108 44.3 COG2207@1|root,COG2207@2|Bacteria,4NPJ8@976|Bacteroidetes,1IXYU@117747|Sphingobacteriia 976|Bacteroidetes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_508103_1 1095769.CAHF01000011_gene2174 8.11e-58 199.0 COG2199@1|root,COG3614@1|root,COG2199@2|Bacteria,COG3614@2|Bacteria,1RGCV@1224|Proteobacteria,2WGZP@28216|Betaproteobacteria,47960@75682|Oxalobacteraceae 28216|Betaproteobacteria T CHASE - - - - - - - - - - - - CHASE,GGDEF,PAS_3 k59_255960_1 1366050.N234_29760 2.4e-108 323.0 COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2VMF2@28216|Betaproteobacteria,1K4DE@119060|Burkholderiaceae 28216|Betaproteobacteria F cytosine deaminase codA - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - Amidohydro_3 k59_292092_2 351746.Pput_2703 9.37e-42 144.0 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,1RS01@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_5313_1 1000565.METUNv1_00650 2.84e-18 82.4 COG1397@1|root,COG1397@2|Bacteria,1MXJP@1224|Proteobacteria,2VNAC@28216|Betaproteobacteria,2KZI2@206389|Rhodocyclales 206389|Rhodocyclales O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_5313_2 1101190.ARWB01000001_gene2388 2.56e-88 273.0 COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria,36XYW@31993|Methylocystaceae 28211|Alphaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_5313_3 1000565.METUNv1_00655 4.73e-17 79.7 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,2KVGD@206389|Rhodocyclales 206389|Rhodocyclales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_861212_1 1219031.BBJR01000034_gene2346 5.93e-71 238.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,4AC3Z@80864|Comamonadaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_651175_1 640081.Dsui_0026 2.53e-20 89.4 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,2KVJ2@206389|Rhodocyclales 206389|Rhodocyclales S Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CorC_HlyC,DUF21 k59_1041313_1 1449065.JMLL01000015_gene4206 2.9e-14 77.8 COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,2TRBR@28211|Alphaproteobacteria,43HRD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S ATP-grasp domain - - - ko:K06913 - - - - ko00000 - - - ATP-grasp_3 k59_1005200_1 1353529.M899_3361 4.65e-35 128.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2MSPW@213481|Bdellovibrionales,2WJ5K@28221|Deltaproteobacteria 213481|Bdellovibrionales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1005200_2 862908.BMS_3275 3.61e-44 145.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2MSZK@213481|Bdellovibrionales,2WPH1@28221|Deltaproteobacteria 213481|Bdellovibrionales J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_329520_1 1158610.UC3_00712 1.03e-13 69.7 28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,4HCYQ@91061|Bacilli 91061|Bacilli S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_329520_2 459495.SPLC1_S030420 1.04e-20 93.2 COG0243@1|root,COG0243@2|Bacteria,1G0DW@1117|Cyanobacteria,1H882@1150|Oscillatoriales 1117|Cyanobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narB GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.7.7.2 ko:K00367 ko00910,ko01120,map00910,map01120 M00531 R00791 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_77155_1 1000565.METUNv1_01113 1.44e-121 350.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,2KUI0@206389|Rhodocyclales 206389|Rhodocyclales K transcriptional - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_540233_2 1217713.F993_01341 1.4e-07 52.4 COG3832@1|root,COG3832@2|Bacteria,1NBZN@1224|Proteobacteria,1SCCE@1236|Gammaproteobacteria,3NK21@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF2505) - - - - - - - - - - - - DUF2505 k59_255981_1 1000565.METUNv1_00822 1.85e-57 191.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,2KUQ9@206389|Rhodocyclales 206389|Rhodocyclales FP Exopolyphosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_682738_1 1000565.METUNv1_01196 2.8e-42 144.0 COG4968@1|root,COG4968@2|Bacteria,1MZZW@1224|Proteobacteria,2VU8H@28216|Betaproteobacteria,2KX3T@206389|Rhodocyclales 206389|Rhodocyclales NU Type IV minor pilin ComP, DNA uptake sequence receptor pilE - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_682738_2 1123354.AUDR01000015_gene311 3.82e-11 62.4 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,2VVPQ@28216|Betaproteobacteria,1KRW3@119069|Hydrogenophilales 119069|Hydrogenophilales NU Type II transport protein GspH - - - - - - - - - - - - GspH,N_methyl k59_1079502_1 1000565.METUNv1_02468 8.47e-22 95.1 2DEAJ@1|root,2ZM67@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_754166_1 1121035.AUCH01000006_gene611 2.8e-41 147.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KUMQ@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_754166_2 614083.AWQR01000039_gene1452 1.42e-32 124.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,4AAGS@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1005209_1 1349767.GJA_3863 8.2e-96 306.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,475Z8@75682|Oxalobacteraceae 28216|Betaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1041322_2 1000565.METUNv1_03436 7.87e-32 116.0 2BZ72@1|root,33BFF@2|Bacteria,1NJJK@1224|Proteobacteria,2WAWV@28216|Betaproteobacteria,2KXNF@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_77165_1 1202962.KB907153_gene511 2.17e-29 114.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_399241_1 338969.Rfer_3367 2.52e-126 368.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,4ABHM@80864|Comamonadaceae 28216|Betaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_363061_1 1514988.A0A089FKN8_9CAUD 6e-23 95.1 4QAQV@10239|Viruses,4QPCB@28883|Caudovirales,4QIFH@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding - - - - - - - - - - - - - k59_41831_1 1003200.AXXA_28140 2.88e-90 279.0 COG0553@1|root,COG0553@2|Bacteria,1PN7I@1224|Proteobacteria,2VP2N@28216|Betaproteobacteria 28216|Betaproteobacteria L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair - - - - - - - - - - - - SNF2_N k59_898727_2 1000565.METUNv1_00795 6.24e-21 82.8 2CI9F@1|root,33H5J@2|Bacteria,1NH1E@1224|Proteobacteria,2VXVR@28216|Betaproteobacteria,2KXJZ@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_898727_3 1000565.METUNv1_01631 2.46e-47 159.0 COG2010@1|root,COG2010@2|Bacteria,1RG8M@1224|Proteobacteria,2VS50@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_898727_4 1232683.ADIMK_3628 2.63e-56 181.0 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,1S7F3@1236|Gammaproteobacteria,468P2@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_77181_1 1003200.AXXA_01425 2.79e-13 68.2 2EJJ9@1|root,33DA7@2|Bacteria,1NJCG@1224|Proteobacteria,2VXZJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_41836_1 1000565.METUNv1_02023 1.19e-173 499.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,2KURC@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_399254_1 1198452.Jab_1c02810 1.42e-90 277.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VKK5@28216|Betaproteobacteria,478II@75682|Oxalobacteraceae 28216|Betaproteobacteria C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_436877_1 1198452.Jab_2c24840 2.89e-142 404.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,473EN@75682|Oxalobacteraceae 28216|Betaproteobacteria E branched-chain amino acid livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_651220_1 1177928.TH2_15157 1.32e-17 85.9 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,2JQEW@204441|Rhodospirillales 204441|Rhodospirillales M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_218169_1 301.JNHE01000012_gene1410 3.7e-47 172.0 COG3300@1|root,COG5002@1|root,COG3300@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1YEHU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Bacterial signalling protein N terminal repeat - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_5361_1 1538295.JY96_07790 2.3e-37 143.0 COG2831@1|root,COG2831@2|Bacteria,1PRBP@1224|Proteobacteria,2VHDS@28216|Betaproteobacteria,1KNA4@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Haemolysin secretion/activation protein ShlB/FhaC/HecB fhaC5 - - - - - - - - - - - POTRA_2,ShlB k59_292159_1 688245.CtCNB1_2622 3.94e-98 297.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,2VP76@28216|Betaproteobacteria,4ACAK@80864|Comamonadaceae 28216|Betaproteobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_436909_1 84751.XP_007876027.1 4.89e-22 100.0 COG0675@1|root,2S61S@2759|Eukaryota,3A84T@33154|Opisthokonta,3P6H3@4751|Fungi 4751|Fungi L Probable transposase - - - - - - - - - - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_1041358_1 580332.Slit_1129 8.47e-43 155.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome d1, heme nirS - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_1041358_2 397945.Aave_0875 1.22e-36 134.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,4ABG0@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1005272_1 1000565.METUNv1_02644 2.39e-46 159.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,2KVFK@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar hook protein FlgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_1005272_2 1000565.METUNv1_02645 1.52e-128 369.0 COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,2VISC@28216|Betaproteobacteria,2KUHU@206389|Rhodocyclales 206389|Rhodocyclales N basal body rod protein flgF - - ko:K02391 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_540274_1 870187.Thini_2516 3.55e-29 114.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,45ZQR@72273|Thiotrichales 72273|Thiotrichales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_540274_2 568706.BN118_3514 8.92e-68 210.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,3T3JW@506|Alcaligenaceae 28216|Betaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_508249_1 358220.C380_11515 2.21e-87 286.0 COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG3706@2|Bacteria,1RE33@1224|Proteobacteria,2VRWV@28216|Betaproteobacteria,4AE1D@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,dCache_1 k59_469889_1 640510.BC1001_4454 1.51e-37 129.0 COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,2VQAI@28216|Betaproteobacteria,1K5SW@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1348) - - - ko:K09958 - - - - ko00000 - - - DUF1348 k59_469889_2 232721.Ajs_4098 0.000235 45.4 COG1379@1|root,COG1379@2|Bacteria,1MVED@1224|Proteobacteria,2VJM0@28216|Betaproteobacteria,4AAC2@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4178) - - - - - - - - - - - - DUF4178 k59_399299_1 338969.Rfer_1094 1.71e-74 232.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4ABW2@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_399299_2 644107.SL1157_1269 1.38e-18 83.2 COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,2TRQ0@28211|Alphaproteobacteria,4NB3G@97050|Ruegeria 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K17317 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 k59_399303_1 159087.Daro_1402 2.35e-67 216.0 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,2VM47@28216|Betaproteobacteria,2KUB7@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c554 and c-prime - - - - - - - - - - - - Paired_CXXCH_1 k59_540285_1 1121920.AUAU01000009_gene1844 4.64e-46 155.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1120522_1 1236959.BAMT01000004_gene947 7.28e-10 61.6 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria,2KNPX@206350|Nitrosomonadales 206350|Nitrosomonadales M Sulfatase - - - - - - - - - - - - Sulfatase k59_1120522_2 1000565.METUNv1_02233 0.0 1191.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY2@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_525465_1 864073.HFRIS_023716 1.24e-101 302.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,47384@75682|Oxalobacteraceae 28216|Betaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin - - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_525465_2 1042209.HK44_012335 9.53e-45 155.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1YN80@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1015697_1 1000565.METUNv1_00906 7.19e-108 316.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KVC2@206389|Rhodocyclales 206389|Rhodocyclales L Hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_908470_2 1000565.METUNv1_02649 1.74e-20 88.6 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,2VH35@28216|Betaproteobacteria,2KW3R@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar rod assembly protein muramidase FlgJ flgJ - - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_941332_1 1121033.AUCF01000032_gene2612 1.1e-58 195.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1091505_1 358220.C380_11420 6.46e-17 79.7 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4AAQ4@80864|Comamonadaceae 28216|Betaproteobacteria C pyridine nucleotide-disulphide oxidoreductase dimerisation region lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1091505_2 296591.Bpro_2670 5.68e-70 215.0 COG5405@1|root,COG5405@2|Bacteria,1RAFD@1224|Proteobacteria,2VMEF@28216|Betaproteobacteria,4ACYI@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM 20S proteasome, A and B subunits - - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_480857_1 1000565.METUNv1_01488 2.07e-99 322.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,2KVQ5@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl k59_158990_1 595537.Varpa_1793 9.02e-69 216.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2VJE7@28216|Betaproteobacteria,4ABUU@80864|Comamonadaceae 28216|Betaproteobacteria I Fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_15812_2 232721.Ajs_0397 3.75e-23 90.9 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,4AE21@80864|Comamonadaceae 28216|Betaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_550829_1 398527.Bphyt_3894 1.58e-48 167.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1K2Y1@119060|Burkholderiaceae 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_454411_1 640081.Dsui_2313 4.56e-142 415.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,2KVHT@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_375018_1 1000565.METUNv1_02772 2.56e-96 298.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales 206389|Rhodocyclales V COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_122744_1 365044.Pnap_2935 7.99e-103 308.0 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_203763_1 268407.PWYN_11485 3.35e-32 120.0 COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,4HJ3T@91061|Bacilli,26QU6@186822|Paenibacillaceae 91061|Bacilli L Belongs to the DNA glycosylase MPG family - - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco k59_908498_1 296591.Bpro_2397 1.97e-90 278.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,4AACM@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_908498_2 614083.AWQR01000029_gene2090 5.54e-10 59.3 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,4A9UV@80864|Comamonadaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_454423_1 1031711.RSPO_c01638 3.8e-61 207.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,1K1BW@119060|Burkholderiaceae 28216|Betaproteobacteria I Glycerol acyltransferase aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase,MFS_1 k59_480889_1 1335760.ASTG01000024_gene2302 8e-07 56.2 COG2931@1|root,COG4932@1|root,COG5295@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,COG5295@2|Bacteria,1N9AC@1224|Proteobacteria 1224|Proteobacteria UW domain protein - - - - - - - - - - - - - k59_304246_1 1166018.FAES_3160 5.35e-76 246.0 COG3975@1|root,COG3975@2|Bacteria,4NGTY@976|Bacteroidetes,47KE2@768503|Cytophagia 976|Bacteroidetes S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_407914_1 420662.Mpe_A3467 4.53e-44 162.0 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria,1KMJ9@119065|unclassified Burkholderiales 28216|Betaproteobacteria M repeat protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_525559_1 543728.Vapar_4585 9.12e-107 340.0 COG0553@1|root,COG1787@1|root,COG0553@2|Bacteria,COG1787@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,4ABAD@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM SNF2-related protein - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - DUF3670,Helicase_C,Mrr_cat,SNF2_N k59_1053376_1 614083.AWQR01000019_gene3802 2.4e-78 245.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,4A9Z4@80864|Comamonadaceae 28216|Betaproteobacteria S ErfK YbiS YcfS YnhG - - - - - - - - - - - - YkuD k59_1053379_1 522306.CAP2UW1_1834 3.86e-46 157.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria 28216|Betaproteobacteria ET PFAM Extracellular solute-binding protein, family 3 gltI - - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_1053379_2 312153.Pnuc_1547 0.000201 43.9 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,1K3YE@119060|Burkholderiaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_16599_1 1000565.METUNv1_02904 7.47e-63 194.0 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,2KWKI@206389|Rhodocyclales 206389|Rhodocyclales L NUDIX domain - - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_16599_2 1000565.METUNv1_02905 1.59e-43 144.0 COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,2KWPP@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_408610_1 292415.Tbd_2823 2.99e-153 441.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2VIPG@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_408610_3 1219031.BBJR01000045_gene1776 5.1e-31 110.0 COG3311@1|root,COG3311@2|Bacteria,1NGB9@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - ko:K07733 - - - - ko00000,ko03000 - - - Phage_AlpA k59_408610_4 1177181.T9A_00138 9.18e-29 106.0 COG0358@1|root,COG0358@2|Bacteria,1N364@1224|Proteobacteria,1SDEX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - zf-CHC2 k59_305245_1 1000565.METUNv1_01076 2.05e-127 389.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_348036_1 29581.BW37_05230 2.22e-131 405.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,475Z8@75682|Oxalobacteraceae 28216|Betaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_838369_1 925409.KI911562_gene2508 8e-41 143.0 2CAZH@1|root,2Z7RU@2|Bacteria,4NGM5@976|Bacteroidetes,1ISIA@117747|Sphingobacteriia 976|Bacteroidetes S succinate dehydrogenase sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - - k59_838369_2 471854.Dfer_3970 2.08e-10 60.5 COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia 976|Bacteroidetes C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_375888_1 236097.ADG881_554 2.67e-18 91.7 COG2304@1|root,COG2373@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,1RFDH@1224|Proteobacteria,1S0SI@1236|Gammaproteobacteria 1236|Gammaproteobacteria H PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - CarboxypepD_reg,DUF1194,Prenyltrans k59_978964_1 864051.BurJ1DRAFT_1555 1.51e-60 203.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,1KMR3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1121333_1 395019.Bmul_5743 7.87e-103 306.0 COG3039@1|root,COG3039@2|Bacteria,1N0RN@1224|Proteobacteria,2WG86@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_5 k59_551797_1 640081.Dsui_1595 3.74e-101 308.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,2KUUV@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_803727_1 55529.EKX53833 3.89e-10 60.8 COG1282@1|root,2QQ0A@2759|Eukaryota 2759|Eukaryota C Transhydrogenase - - 1.6.1.2 ko:K00323 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB,PNTB_4TM k59_803727_2 929703.KE386492_gene4310 1.71e-06 50.8 COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,47JQA@768503|Cytophagia 976|Bacteroidetes S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_763790_1 744980.TRICHSKD4_3309 6.47e-103 322.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family - - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_693591_1 614083.AWQR01000028_gene3173 2.54e-76 238.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria 1224|Proteobacteria G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.15,2.7.1.20,2.7.1.4 ko:K00847,ko:K00852,ko:K00856 ko00030,ko00051,ko00230,ko00500,ko00520,ko01100,map00030,map00051,map00230,map00500,map00520,map01100 - R00185,R00760,R00867,R01051,R02750,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_693591_2 614083.AWQR01000028_gene3175 7.63e-26 106.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,4AB1Y@80864|Comamonadaceae 28216|Betaproteobacteria KL SMART helicase c2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_730272_1 1000565.METUNv1_01987 2.56e-206 589.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KXW1@206389|Rhodocyclales 206389|Rhodocyclales K GAF domain - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_348077_1 83406.HDN1F_18970 1.78e-69 229.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1121345_1 1283300.ATXB01000001_gene1668 2.91e-10 58.2 COG4226@1|root,COG4226@2|Bacteria,1MZE7@1224|Proteobacteria,1S99M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein encoded in hypervariable junctions of pilus gene clusters - - - - - - - - - - - - HicB k59_1121345_2 1336208.JADY01000007_gene1660 2.51e-09 60.1 COG0697@1|root,COG0697@2|Bacteria,1R6CU@1224|Proteobacteria,2UCTR@28211|Alphaproteobacteria,2JTT2@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_526907_1 1223521.BBJX01000003_gene2614 1.69e-54 184.0 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria,4ABPR@80864|Comamonadaceae 28216|Betaproteobacteria P Parallel beta-helix repeat nosD - - ko:K07218 - - - - ko00000 - - - NosD k59_348087_1 398578.Daci_1933 1.14e-116 342.0 COG0305@1|root,COG0305@2|Bacteria,1PP51@1224|Proteobacteria,2VQ9Z@28216|Betaproteobacteria 28216|Betaproteobacteria L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C k59_978999_1 1000565.METUNv1_03715 2.61e-128 379.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,2KV8V@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K07649 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_551837_1 614083.AWQR01000005_gene1168 1.06e-27 116.0 COG1231@1|root,COG1231@2|Bacteria,1NVGR@1224|Proteobacteria,2VJU0@28216|Betaproteobacteria,4AB24@80864|Comamonadaceae 28216|Betaproteobacteria E Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_526964_1 640081.Dsui_1223 2.51e-24 97.1 COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,2KWYS@206389|Rhodocyclales 206389|Rhodocyclales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_526964_2 640081.Dsui_1224 1.83e-37 140.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,2KV8K@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_873560_1 1005048.CFU_1468 6.02e-35 127.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,472KP@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_53119_1 765913.ThidrDRAFT_2555 7.64e-25 97.8 COG1846@1|root,COG1846@2|Bacteria,1N19E@1224|Proteobacteria,1S6YD@1236|Gammaproteobacteria,1WYIS@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K06075 - - - - ko00000,ko03000 - - - MarR,MarR_2 k59_53119_2 765913.ThidrDRAFT_2554 7.88e-69 228.0 COG1289@1|root,COG1289@2|Bacteria,1MX9H@1224|Proteobacteria,1RSD7@1236|Gammaproteobacteria,1WXR6@135613|Chromatiales 135613|Chromatiales S Fusaric acid resistance protein - - - - - - - - - - - - FUSC k59_979051_1 266264.Rmet_3681 3.27e-34 125.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,2VR41@28216|Betaproteobacteria,1K21C@119060|Burkholderiaceae 28216|Betaproteobacteria NT chemotaxis protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_730334_1 1000565.METUNv1_03867 4.92e-132 381.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KUFJ@206389|Rhodocyclales 206389|Rhodocyclales S phosphotransferase related to Ser Thr protein kinases - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_123742_1 306281.AJLK01000151_gene2054 1.58e-28 105.0 2EHP8@1|root,33BF1@2|Bacteria 2|Bacteria S Multiubiquitin - - - - - - - - - - - - Multi_ubiq k59_1121418_1 1157708.KB907455_gene3365 0.000293 49.3 COG0189@1|root,COG0189@2|Bacteria,1QVU3@1224|Proteobacteria,2WH5E@28216|Betaproteobacteria,4AAK1@80864|Comamonadaceae 28216|Betaproteobacteria HJ glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_763869_2 1144319.PMI16_02810 5.28e-42 148.0 COG3832@1|root,COG3832@2|Bacteria,1N3W1@1224|Proteobacteria,2VVEF@28216|Betaproteobacteria 28216|Betaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_88016_1 614083.AWQR01000031_gene2613 8.99e-32 125.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,4AAY1@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_873597_1 1396418.BATQ01000175_gene2785 2.23e-32 130.0 COG1413@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - Copper-bind,Cytochrom_C,DUF1080,HEAT_2,Laminin_G_3,Lipase_GDSL_2,ThuA k59_693688_1 1387312.BAUS01000012_gene2081 4.22e-16 82.0 COG4625@1|root,COG4625@2|Bacteria,1R9VZ@1224|Proteobacteria,2WEH9@28216|Betaproteobacteria 28216|Betaproteobacteria U Autotransporter beta-domain - - - - - - - - - - - - Autotransporter,ESPR k59_348238_1 614083.AWQR01000009_gene699 5.46e-16 71.6 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,4AEH1@80864|Comamonadaceae 28216|Betaproteobacteria U TIGRFAM preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_348238_2 614083.AWQR01000009_gene698 2.2e-57 194.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,4A9UJ@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_481955_1 1552758.NC00_15365 5.46e-74 232.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X3A0@135614|Xanthomonadales 135614|Xanthomonadales S dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_268182_2 1336235.JAEG01000002_gene122 9.36e-23 95.1 COG3739@1|root,COG3739@2|Bacteria,1PMEC@1224|Proteobacteria,2TRGD@28211|Alphaproteobacteria,4BBTW@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF817) - - - - - - - - - - - - DUF817 k59_778534_1 323098.Nwi_2073 2.35e-35 132.0 COG0614@1|root,COG0614@2|Bacteria,1PGUA@1224|Proteobacteria,2VG1P@28211|Alphaproteobacteria,3JXY4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1103048_1 614083.AWQR01000005_gene1283 4.75e-69 211.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,4ADFY@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0234 family yajQ - - ko:K09767 - - - - ko00000 - - - DUF520 k59_1103048_2 614083.AWQR01000005_gene1282 3.2e-33 124.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,4AA6J@80864|Comamonadaceae 28216|Betaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_709432_1 338969.Rfer_2422 4.72e-96 303.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,4AA9J@80864|Comamonadaceae 28216|Betaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_177181_1 1000565.METUNv1_01138 8.11e-129 382.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,2KUU5@206389|Rhodocyclales 206389|Rhodocyclales T EAL domain - - - - - - - - - - - - EAL,GGDEF k59_105924_1 1504672.669786516 1.05e-23 99.4 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,4AA8E@80864|Comamonadaceae 28216|Betaproteobacteria C nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein nirB - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_105924_2 358220.C380_17495 3.41e-70 213.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2VSP4@28216|Betaproteobacteria,4AEC0@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM nitrite reductase NAD(P)H , small subunit nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_105924_3 543728.Vapar_3530 9.02e-63 213.0 COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,4AB7E@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_139934_1 883126.HMPREF9710_00528 9.96e-26 105.0 COG1639@1|root,COG2203@1|root,COG1639@2|Bacteria,COG2203@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,475W8@75682|Oxalobacteraceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - GAF,GAF_2,HDOD,Pkinase k59_139934_2 1095769.CAHF01000006_gene1844 4.18e-21 88.2 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2VN4R@28216|Betaproteobacteria,473RK@75682|Oxalobacteraceae 28216|Betaproteobacteria E efflux protein - - - ko:K05834 - - - - ko00000,ko02000 2.A.76.1.1 - - LysE k59_956030_1 1122605.KB893635_gene3498 5.8e-105 325.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,1IQ8E@117747|Sphingobacteriia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_284530_1 123899.JPQP01000021_gene3584 4.15e-50 166.0 COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,2VRMP@28216|Betaproteobacteria 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_69006_1 926551.KB900739_gene96 9.14e-65 212.0 COG0348@1|root,COG0348@2|Bacteria,4NFDN@976|Bacteroidetes,1HXAK@117743|Flavobacteriia,1EQRS@1016|Capnocytophaga 976|Bacteroidetes C Cytochrome c oxidase accessory protein CcoG ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_778564_1 1122176.KB903541_gene173 5.77e-38 137.0 COG1028@1|root,COG1028@2|Bacteria,4NEK1@976|Bacteroidetes,1IQGZ@117747|Sphingobacteriia 976|Bacteroidetes IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_32672_1 614083.AWQR01000020_gene174 3.78e-103 304.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,4AB2X@80864|Comamonadaceae 28216|Betaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_241948_2 29581.BW37_03792 2.31e-35 129.0 COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2VIA3@28216|Betaproteobacteria,478GW@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_778582_1 876269.ARWA01000001_gene1200 4.14e-36 138.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,3NCTG@45404|Beijerinckiaceae 28211|Alphaproteobacteria M HlyD membrane-fusion protein of T1SS - - - - - - - - - - - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_177245_1 366602.Caul_4809 2.55e-29 116.0 2EYUR@1|root,33S1X@2|Bacteria,1NSGH@1224|Proteobacteria,2UPVW@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_956072_1 269796.Rru_A3137 2.62e-35 137.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQE1@204441|Rhodospirillales 204441|Rhodospirillales T COG2202 FOG PAS PAC domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9,Response_reg k59_599184_1 1193729.A1OE_596 3.78e-98 295.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,2JPWU@204441|Rhodospirillales 204441|Rhodospirillales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_599184_2 72558.CBQ72567 1.01e-06 55.8 COG0839@1|root,2S14H@2759|Eukaryota,3A3YI@33154|Opisthokonta,3P44Q@4751|Fungi,3V22X@5204|Basidiomycota 4751|Fungi Q NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nad6 - 1.6.5.3 ko:K03884 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - Oxidored_q3 k59_778603_1 929562.Emtol_1415 6.39e-17 85.1 COG1807@1|root,COG1807@2|Bacteria,4NE7V@976|Bacteroidetes,47MVT@768503|Cytophagia 976|Bacteroidetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_818710_1 640512.BC1003_4857 5.94e-48 169.0 COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,2VKBF@28216|Betaproteobacteria,1K1HM@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM extracellular solute-binding protein family 1 - - - ko:K17321 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - SBP_bac_1,SBP_bac_8 k59_709519_1 296591.Bpro_0076 4.86e-95 282.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,4AAI0@80864|Comamonadaceae 28216|Betaproteobacteria D Cobyrinic acid ac-diamide synthase parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_747336_2 596154.Alide2_4435 2.3e-70 218.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,4ABQP@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ABC transporter related lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_242020_1 391008.Smal_1187 5.66e-36 126.0 2DA9N@1|root,32TUZ@2|Bacteria,1QVBT@1224|Proteobacteria,1S8UR@1236|Gammaproteobacteria,1XD95@135614|Xanthomonadales 135614|Xanthomonadales S EamA-like transporter family - - - - - - - - - - - - EamA k59_1137844_1 1000565.METUNv1_00382 2e-180 512.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,2KUMC@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_818768_1 1198452.Jab_1c05880 1.89e-41 154.0 COG1874@1|root,COG4409@1|root,COG1874@2|Bacteria,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - 3.2.1.18,3.2.1.4,3.2.1.52,3.2.1.97 ko:K01179,ko:K01186,ko:K12373,ko:K17624 ko00500,ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko04142,map00500,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map04142 M00079 R00022,R04018,R06004,R06200,R11307,R11308,R11316 RC00028,RC00049,RC00077 ko00000,ko00001,ko00002,ko01000,ko02042,ko03110 - GH101,GH20,GH33,GH5,GH9 - ASH,BNR_2,CelD_N,Glyco_hydro_9,NPCBM,NPCBM_assoc k59_709572_1 748247.AZKH_2589 1.64e-39 138.0 COG3440@1|root,COG3440@2|Bacteria,1N4JP@1224|Proteobacteria,2VVU0@28216|Betaproteobacteria 28216|Betaproteobacteria V HNH endonuclease - - - ko:K07454 - - - - ko00000 - - - HNH_2 k59_570050_2 1000565.METUNv1_01836 1.2e-69 215.0 2DKJT@1|root,309RD@2|Bacteria,1R36E@1224|Proteobacteria 1224|Proteobacteria S Chlorite dismutase - - - - - - - - - - - - Chlor_dismutase k59_423836_1 1095769.CAHF01000022_gene99 1.87e-54 178.0 COG1309@1|root,COG1309@2|Bacteria,1RE7F@1224|Proteobacteria,2VSAW@28216|Betaproteobacteria 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_423836_2 358220.C380_09505 6.34e-59 189.0 COG3687@1|root,COG3687@2|Bacteria,1R6G1@1224|Proteobacteria,2WFRN@28216|Betaproteobacteria,4ACGX@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_284695_1 9478.XP_008049381.1 2.18e-12 73.2 COG2124@1|root,KOG0157@2759|Eukaryota,38BG9@33154|Opisthokonta,3B9AK@33208|Metazoa,3CZX1@33213|Bilateria,485IE@7711|Chordata,4937D@7742|Vertebrata,3JD15@40674|Mammalia,35JX2@314146|Euarchontoglires,4MI8H@9443|Primates 33208|Metazoa Q Cytochrome P450, family 46, subfamily A, polypeptide 1 CYP46A1 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006066,GO:0006082,GO:0006629,GO:0006694,GO:0006699,GO:0006706,GO:0006707,GO:0006805,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008206,GO:0008395,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009987,GO:0012505,GO:0016020,GO:0016042,GO:0016053,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0019752,GO:0020037,GO:0031090,GO:0031984,GO:0032501,GO:0032502,GO:0032787,GO:0033781,GO:0042175,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046164,GO:0046394,GO:0046906,GO:0048037,GO:0048731,GO:0048856,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071466,GO:0071704,GO:0072330,GO:0097159,GO:0098827,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1902652 1.14.14.25 ko:K07440 ko00120,map00120 - R07207 RC00773 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_1137880_1 748247.AZKH_3170 6.95e-157 449.0 2C4IG@1|root,2Z8A1@2|Bacteria,1QTHZ@1224|Proteobacteria,2VJBR@28216|Betaproteobacteria,2KV8B@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_32813_1 522306.CAP2UW1_1552 1.04e-83 252.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,1KQ2H@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_32813_2 640081.Dsui_2461 2.26e-19 84.7 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2VHYP@28216|Betaproteobacteria,2KVT3@206389|Rhodocyclales 206389|Rhodocyclales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_69169_1 243090.RB7907 7.39e-39 137.0 COG0657@1|root,COG0657@2|Bacteria,2IXWJ@203682|Planctomycetes 203682|Planctomycetes I COG0657 Esterase lipase - - - - - - - - - - - - Abhydrolase_3 k59_632940_2 1116472.MGMO_85c00330 7.73e-29 111.0 2E884@1|root,332M7@2|Bacteria,1NG21@1224|Proteobacteria,1SFK5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (Hypoth_ymh) - - - - - - - - - - - - Hypoth_Ymh k59_1106091_1 640081.Dsui_1691 6.68e-123 377.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,2KVTG@206389|Rhodocyclales 206389|Rhodocyclales D DNA segregation ATPase FtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_601758_1 278957.ABEA03000202_gene4306 3.48e-56 186.0 COG1291@1|root,COG1291@2|Bacteria,46UCQ@74201|Verrucomicrobia,3K773@414999|Opitutae 414999|Opitutae N MotA/TolQ/ExbB proton channel family - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_632997_1 112098.XP_008610777.1 4.52e-37 134.0 COG0378@1|root,2QR6E@2759|Eukaryota 2759|Eukaryota KO nickel cation binding UREG GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019627,GO:0034641,GO:0043085,GO:0043603,GO:0044093,GO:0044237,GO:0044281,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0071941,GO:1901564 - ko:K03189 - - - - ko00000 - - - cobW k59_632998_1 391735.Veis_2049 4.37e-62 197.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,4ABUX@80864|Comamonadaceae 28216|Betaproteobacteria F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation ydiA - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_632998_2 882378.RBRH_00043 6.16e-05 44.7 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,1K0K1@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_820880_1 204773.HEAR2721 1.37e-42 151.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,473E1@75682|Oxalobacteraceae 28216|Betaproteobacteria G PFAM Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II, Phosphoglucomutase phosphomannomutase, alpha beta alpha domain III, Phosphoglucomutase phosphomannomutase, C-terminal domain, Phosphoglucomutase phosphomannomutase, alpha beta alpha domain I algC GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_820880_2 626418.bglu_1g07490 6.04e-25 101.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VPK7@28216|Betaproteobacteria,1K3C2@119060|Burkholderiaceae 28216|Betaproteobacteria M lipopolysaccharide heptosyltransferase I rfaC - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_601806_1 305700.B447_00785 3.3e-87 269.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2VJE2@28216|Betaproteobacteria,2KV9U@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_244883_1 614083.AWQR01000043_gene3527 7.7e-55 178.0 COG1116@1|root,COG1116@2|Bacteria,1MXMA@1224|Proteobacteria,2VKJY@28216|Betaproteobacteria,4AB60@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM ABC transporter related - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_244883_2 614083.AWQR01000005_gene1165 1.24e-57 182.0 COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,4ADNK@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM flavin reductase domain protein, FMN-binding - - - - - - - - - - - - Flavin_Reduct k59_997809_1 1173022.Cri9333_3618 4.16e-29 120.0 COG0515@1|root,COG0642@1|root,COG0745@1|root,COG2198@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_712446_1 1348657.M622_19050 1.27e-32 121.0 COG3645@1|root,COG3645@2|Bacteria,1MVMT@1224|Proteobacteria,2WBCB@28216|Betaproteobacteria,2KZ2E@206389|Rhodocyclales 206389|Rhodocyclales S DNA-damage-inducible protein d - - - - - - - - - - - - - k59_926453_1 1198452.Jab_2c29580 1.37e-93 296.0 COG3227@1|root,COG3227@2|Bacteria,1R61F@1224|Proteobacteria,2VUWX@28216|Betaproteobacteria,474TB@75682|Oxalobacteraceae 28216|Betaproteobacteria E Thermolysin metallopeptidase, alpha-helical domain - - - ko:K20273 ko02024,map02024 - - - ko00000,ko00001,ko01002 - - - FTP,Peptidase_M4,Peptidase_M4_C k59_633098_1 452863.Achl_3692 1.08e-111 327.0 COG1028@1|root,COG1028@2|Bacteria,2INQX@201174|Actinobacteria 201174|Actinobacteria IQ short-chain dehydrogenase - - 1.1.1.47 ko:K00034 ko00030,ko01120,ko01200,map00030,map01120,map01200 - R01520,R01521 RC00066 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_601927_2 1288494.EBAPG3_28100 4.42e-67 214.0 2EMF3@1|root,2ZKNW@2|Bacteria,1RAZA@1224|Proteobacteria,2VQE2@28216|Betaproteobacteria,37464@32003|Nitrosomonadales 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_997920_1 614083.AWQR01000035_gene3631 1.88e-43 156.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,4AACI@80864|Comamonadaceae 28216|Betaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_997920_2 614083.AWQR01000035_gene3630 3.3e-17 76.6 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,4AAJV@80864|Comamonadaceae 28216|Betaproteobacteria K transcriptional regulator, Rrf2 family iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_781719_1 1283335.Q6QIC1_BPBMU 5.34e-65 214.0 4QD6B@10239|Viruses,4QYNM@35237|dsDNA viruses no RNA stage,4QU4T@28883|Caudovirales,4QJH1@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_601929_1 929703.KE386491_gene1191 2.14e-94 300.0 COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,47JFD@768503|Cytophagia 976|Bacteroidetes G PFAM Glycoside hydrolase, family 20, catalytic core - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX,CHB_HEX_C,Glyco_hydro_20,Glyco_hydro_20b k59_245014_2 768671.ThimaDRAFT_0810 7.51e-05 45.8 COG1845@1|root,COG1845@2|Bacteria,1RG3S@1224|Proteobacteria,1S75W@1236|Gammaproteobacteria,1X13A@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase subunit III - - - - - - - - - - - - COX3 k59_426193_1 365044.Pnap_3902 2.1e-70 237.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_426209_1 358220.C380_01315 5.21e-144 433.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,4ABCX@80864|Comamonadaceae 28216|Betaproteobacteria V TIGRFAM type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1106322_1 1198452.Jab_2c33200 2.42e-26 106.0 COG2199@1|root,COG3706@2|Bacteria,1R9NB@1224|Proteobacteria,2VSWC@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,HAMP k59_712586_1 1265502.KB905946_gene1115 4.8e-83 254.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,4AAWA@80864|Comamonadaceae 28216|Betaproteobacteria O Peptidase U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_926630_2 1129374.AJE_10458 6.42e-45 163.0 COG4637@1|root,COG4938@1|root,COG4637@2|Bacteria,COG4938@2|Bacteria,1NEEG@1224|Proteobacteria,1RZMD@1236|Gammaproteobacteria,468W7@72275|Alteromonadaceae 1236|Gammaproteobacteria S AAA ATPase domain - - - - - - - - - - - - AAA_15,DUF3696 k59_712614_1 472759.Nhal_3250 1.72e-09 59.7 COG0110@1|root,COG0110@2|Bacteria,1N0CM@1224|Proteobacteria 1224|Proteobacteria S maltose O-acetyltransferase activity - - - - - - - - - - - - Hexapep k59_1140586_2 1249627.D779_2726 3.61e-66 222.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,1WX1F@135613|Chromatiales 135613|Chromatiales L Type III restriction - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII k59_633249_1 1198452.Jab_1c10350 1.07e-46 164.0 COG0330@1|root,COG0330@2|Bacteria,1MXFX@1224|Proteobacteria,2VP3U@28216|Betaproteobacteria,476VC@75682|Oxalobacteraceae 28216|Betaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1140621_1 1232683.ADIMK_0604 3.17e-68 215.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,464SP@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_426276_1 1149133.ppKF707_1589 2.95e-56 186.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1YEFY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Belongs to the citrate synthase family gltA GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_00727 Citrate_synt k59_602091_1 768671.ThimaDRAFT_1481 2.66e-64 206.0 COG1089@1|root,COG1089@2|Bacteria,1R9QJ@1224|Proteobacteria,1S1QW@1236|Gammaproteobacteria,1WVZK@135613|Chromatiales 135613|Chromatiales M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose - - - - - - - - - - - - GDP_Man_Dehyd k59_602091_2 1128427.KB904821_gene4468 6.12e-21 92.4 COG1089@1|root,COG1089@2|Bacteria,1G0M4@1117|Cyanobacteria,1H6XT@1150|Oscillatoriales 1117|Cyanobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_781889_1 10042.XP_006973917.1 4.73e-62 210.0 COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3BCEE@33208|Metazoa,3CU79@33213|Bilateria,489CP@7711|Chordata,497ZQ@7742|Vertebrata,3J34Z@40674|Mammalia,35DYV@314146|Euarchontoglires,4Q0CE@9989|Rodentia 33208|Metazoa C Produces ATP from ADP in the presence of a proton gradient across the membrane ATP5A1 GO:0000166,GO:0000275,GO:0001936,GO:0001937,GO:0003674,GO:0003824,GO:0005102,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008285,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010594,GO:0010595,GO:0010632,GO:0010634,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030334,GO:0030335,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040012,GO:0040017,GO:0042127,GO:0042287,GO:0042288,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043168,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0043531,GO:0043532,GO:0043535,GO:0043536,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045121,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050678,GO:0050680,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051270,GO:0051272,GO:0055085,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0097159,GO:0097367,GO:0098589,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098805,GO:0098857,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:2000145,GO:2000147 - ko:K02132 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_245213_2 575564.HMPREF0014_00738 3.48e-10 58.5 28HXV@1|root,2Z83C@2|Bacteria,1PJBP@1224|Proteobacteria,1RYDU@1236|Gammaproteobacteria,3NM0Y@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_712771_1 1123367.C666_08920 1.33e-77 239.0 arCOG09463@1|root,2Z8U6@2|Bacteria,1NHE7@1224|Proteobacteria,2VZUV@28216|Betaproteobacteria 28216|Betaproteobacteria S DNA-sulfur modification-associated - - - ko:K19169 - - - - ko00000,ko02048 - - - DndB k59_712771_2 768671.ThimaDRAFT_0308 1.28e-34 132.0 COG0175@1|root,COG0175@2|Bacteria,1MXNT@1224|Proteobacteria,1RYKC@1236|Gammaproteobacteria,1WXDX@135613|Chromatiales 135613|Chromatiales EH PFAM Phosphoadenosine phosphosulfate reductase - - - ko:K19170 - - - - ko00000,ko02048 - - - PAPS_reduct k59_926847_1 743719.PaelaDRAFT_2227 1.65e-17 84.7 COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,4HAA1@91061|Bacilli,26S9E@186822|Paenibacillaceae 91061|Bacilli J SAM-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Cons_hypoth95,Met_10,Methyltrans_SAM,Methyltransf_31 k59_965112_1 1000565.METUNv1_01317 1.2e-114 333.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2VHUX@28216|Betaproteobacteria,2KUZC@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_965112_2 1000565.METUNv1_01316 1.4e-75 236.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,2KVDP@206389|Rhodocyclales 206389|Rhodocyclales E PFAM Aminotransferase class I and II dapC - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_394500_1 1000565.METUNv1_03295 9.77e-147 421.0 COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,2KV95@206389|Rhodocyclales 206389|Rhodocyclales S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_394500_2 1000565.METUNv1_03296 1.92e-308 849.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales 206389|Rhodocyclales I poly(R)-hydroxyalkanoic acid synthase - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_323636_2 1000565.METUNv1_00994 2.2e-19 87.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria,2KX5Q@206389|Rhodocyclales 206389|Rhodocyclales U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_965116_1 1031711.RSPO_c02593 4.75e-14 71.6 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,2VJPP@28216|Betaproteobacteria,1K3J7@119060|Burkholderiaceae 28216|Betaproteobacteria H PFAM UBA THIF-type NAD FAD binding protein moeB - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_894113_2 1005048.CFU_3609 5.61e-99 298.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2VH9V@28216|Betaproteobacteria,4737E@75682|Oxalobacteraceae 28216|Betaproteobacteria T Phosphate starvation-inducible protein ybeZ - - ko:K06217 - - - - ko00000 - - - PhoH k59_502166_1 457570.Nther_2110 1.93e-10 67.0 COG2199@1|root,COG3437@1|root,COG4936@1|root,COG5002@1|root,COG2199@2|Bacteria,COG3437@2|Bacteria,COG4936@2|Bacteria,COG5002@2|Bacteria,1TQ0S@1239|Firmicutes 1239|Firmicutes T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HD,HD_5,HisKA_7TM,PAS,PAS_3,PAS_4,PAS_9,PocR k59_180775_1 1000565.METUNv1_00300 5.46e-100 305.0 COG3182@1|root,COG3182@2|Bacteria,1MUX8@1224|Proteobacteria,2VP77@28216|Betaproteobacteria,2KWD6@206389|Rhodocyclales 206389|Rhodocyclales S PFAM PepSY-associated TM helix domain protein - - - - - - - - - - - - PepSY_TM k59_180775_2 1000565.METUNv1_00301 5.97e-68 213.0 2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,2W4MN@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_72747_1 228410.NE2119 2.77e-253 697.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2VIY1@28216|Betaproteobacteria,3737Y@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Filamentation induced by cAMP death on - - - - - - - - - - - - Fic,Fic_N,HTH_13,HTH_24 k59_72747_2 420662.Mpe_A0406 4.58e-48 157.0 COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2VU9A@28216|Betaproteobacteria,1KMB9@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_323645_2 293613.A1E_00100 3.02e-29 114.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,47EYQ@766|Rickettsiales 766|Rickettsiales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1712_1 1000565.METUNv1_00821 1.33e-110 337.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_215601_1 614083.AWQR01000046_gene3332 1.31e-102 317.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,4A9KV@80864|Comamonadaceae 28216|Betaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_715807_1 1000565.METUNv1_01924 9.44e-118 343.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,2KUSK@206389|Rhodocyclales 206389|Rhodocyclales S Stress-induced protein - - - - - - - - - - - - DUF1732,YicC_N k59_715807_2 748247.AZKH_1688 5.72e-149 426.0 COG2837@1|root,COG2837@2|Bacteria,1MWDD@1224|Proteobacteria,2VKMS@28216|Betaproteobacteria 28216|Betaproteobacteria C Dyp-type peroxidase family dyp - - ko:K07223 - - - - ko00000 - - - Dyp_perox k59_37523_1 1276756.AUEX01000001_gene974 4.17e-52 165.0 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,4AEC2@80864|Comamonadaceae 28216|Betaproteobacteria J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_37523_2 1268622.AVS7_00629 7.11e-18 77.0 COG0454@1|root,COG0456@2|Bacteria,1N7JM@1224|Proteobacteria,2VU1F@28216|Betaproteobacteria,4AEBG@80864|Comamonadaceae 28216|Betaproteobacteria K Protein of unknown function (DUF3579) - - - - - - - - - - - - DUF3579 k59_465704_1 1000565.METUNv1_02043 1.46e-149 426.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,2KUI2@206389|Rhodocyclales 206389|Rhodocyclales S membrane transporter protein - - - - - - - - - - - - TauE k59_894125_1 266264.Rmet_2247 1.49e-13 76.3 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein - - 3.1.4.52 ko:K13243 - - R08991 RC00296 ko00000,ko01000 - - - CHASE4,EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_679582_2 1000565.METUNv1_00089 3.49e-147 417.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,2KUR3@206389|Rhodocyclales 206389|Rhodocyclales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_822560_1 1000565.METUNv1_00337 5.54e-10 56.2 COG1334@1|root,COG1334@2|Bacteria,1NH9T@1224|Proteobacteria,2VXXM@28216|Betaproteobacteria,2KXC0@206389|Rhodocyclales 206389|Rhodocyclales N FlaG protein - - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG k59_822560_2 261292.Nit79A3_0914 4.79e-65 223.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,371U5@32003|Nitrosomonadales 28216|Betaproteobacteria N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_894134_1 938709.AUSH02000053_gene143 8.42e-86 265.0 COG0520@1|root,COG0520@2|Bacteria,4NF4G@976|Bacteroidetes 976|Bacteroidetes E PFAM aminotransferase class V - - 5.1.1.17 ko:K04127 ko00311,ko01100,ko01130,map00311,map01100,map01130 M00673 R04147 RC00302 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_37537_1 1000565.METUNv1_00367 3.81e-106 314.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,2KUP3@206389|Rhodocyclales 206389|Rhodocyclales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_72761_1 640081.Dsui_1943 9.81e-167 481.0 COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,2KUBW@206389|Rhodocyclales 206389|Rhodocyclales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_965134_1 1163398.AJJP01000167_gene1740 1.01e-68 233.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1107989_2 1000565.METUNv1_02480 2.31e-167 469.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,2KUY1@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1107989_3 1000565.METUNv1_02482 3.78e-221 619.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,2KU8G@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1073289_1 1123487.KB892846_gene529 9.76e-96 291.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,2KURP@206389|Rhodocyclales 206389|Rhodocyclales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_215612_2 1000565.METUNv1_03330 5.45e-161 457.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,2KUYP@206389|Rhodocyclales 206389|Rhodocyclales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_215612_3 626418.bglu_2g02020 1.24e-76 242.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K43J@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family dbpA GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_251731_1 1123367.C666_15715 1.13e-104 312.0 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,2KUJA@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the precorrin methyltransferase family - - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase k59_251731_2 1123367.C666_03765 1.67e-80 240.0 COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VQ50@28216|Betaproteobacteria,2KW5Y@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c norC - - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_251731_3 1123354.AUDR01000013_gene524 5.44e-288 791.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,1KRSZ@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome C and Quinol oxidase polypeptide I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_1108001_1 91464.S7335_2682 2.16e-15 76.6 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated MA20_19850 - - ko:K10917 ko02024,ko05111,map02024,map05111 - - - ko00000,ko00001,ko03000 - - - PadR,Vir_act_alpha_C k59_1108001_2 1458427.BAWN01000018_gene1142 8.15e-24 93.2 COG3744@1|root,COG3744@2|Bacteria,1N2T0@1224|Proteobacteria,2VTSR@28216|Betaproteobacteria,4AINI@80864|Comamonadaceae 28216|Betaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_215619_1 1223521.BBJX01000013_gene429 0.00021 48.9 COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,2VN8D@28216|Betaproteobacteria,4AJ3S@80864|Comamonadaceae 28216|Betaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_751073_1 153948.NAL212_2705 1.07e-18 84.7 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,371ZY@32003|Nitrosomonadales 28216|Betaproteobacteria HL Belongs to the Nudix hydrolase family mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,TMP-TENI k59_751073_2 1454004.AW11_03377 2.1e-111 328.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,1KPP1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S General function prediction only - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_787260_1 522306.CAP2UW1_2671 6.28e-93 281.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KQ81@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Sodium Bile acid symporter family - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_715837_1 1538295.JY96_05455 4.96e-31 121.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,1KKDF@119065|unclassified Burkholderiales 28216|Betaproteobacteria H acetolactate synthase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_715837_2 1506583.JQJY01000003_gene3599 6.02e-63 204.0 COG1028@1|root,COG1028@2|Bacteria,4NF7M@976|Bacteroidetes,1HYQX@117743|Flavobacteriia,2NV9T@237|Flavobacterium 976|Bacteroidetes IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_180827_1 1504672.669783218 1.13e-11 63.5 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria,4ACXC@80864|Comamonadaceae 28216|Betaproteobacteria S NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_180827_2 102232.GLO73106DRAFT_00015790 1.04e-16 85.5 COG1520@1|root,COG3210@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125,ko:K19231 ko05133,map05133 - - - ko00000,ko00001,ko00536,ko02000 1.B.12 - - DUF637,ESPR,Fil_haemagg_2,Haemagg_act,PT-VENN k59_1036967_1 1000565.METUNv1_02660 1.72e-26 107.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,2KUPN@206389|Rhodocyclales 206389|Rhodocyclales NU COG3170 Tfp pilus assembly protein FimV - - - ko:K08086 - - - - ko00000 - - - LysM k59_1036967_3 1000565.METUNv1_02662 1.72e-138 397.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,2KU8S@206389|Rhodocyclales 206389|Rhodocyclales J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_1036967_4 1000565.METUNv1_02663 4.94e-59 187.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,2KU7Q@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_929165_1 1000565.METUNv1_04040 3.81e-168 484.0 COG3746@1|root,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,2VNJT@28216|Betaproteobacteria 28216|Betaproteobacteria P Putative porin - - - - - - - - - - - - Porin_5 k59_536826_1 1000565.METUNv1_02559 2.14e-118 350.0 COG4222@1|root,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,2VM0N@28216|Betaproteobacteria,2KWFH@206389|Rhodocyclales 206389|Rhodocyclales S Esterase-like activity of phytase - - - - - - - - - - - - Phytase-like k59_536826_2 1000565.METUNv1_02560 2.09e-18 83.2 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,2KUJ7@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_72773_1 1000565.METUNv1_00617 5.06e-56 183.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KUA0@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_72773_2 1000565.METUNv1_00618 3.35e-209 581.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,2KUAG@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_72773_3 1000565.METUNv1_00619 3.75e-56 183.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,2KV8M@206389|Rhodocyclales 206389|Rhodocyclales I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_37569_1 1000565.METUNv1_02202 1.82e-106 338.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE1,PAS,PAS_3,PAS_4,PAS_9 k59_1073314_1 1000565.METUNv1_00038 0.0 1020.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KUM5@206389|Rhodocyclales 206389|Rhodocyclales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_394566_2 543728.Vapar_4875 1.41e-51 163.0 COG0636@1|root,COG0636@2|Bacteria,1R359@1224|Proteobacteria,2WIFK@28216|Betaproteobacteria 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1001014_1 1532558.JL39_23650 8.18e-216 613.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4BIIW@82115|Rhizobiaceae 28211|Alphaproteobacteria EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1001803_1 384676.PSEEN1901 7.65e-47 159.0 COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,1RYXQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional prpR - - - - - - - - - - - FCD,GntR k59_38677_1 1223521.BBJX01000013_gene389 4.84e-101 309.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,4AA35@80864|Comamonadaceae 28216|Betaproteobacteria C FAD dependent oxidoreductase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_716889_1 452637.Oter_0409 1.66e-54 182.0 COG1338@1|root,COG1338@2|Bacteria,46USW@74201|Verrucomicrobia,3K7PQ@414999|Opitutae 414999|Opitutae N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_288564_1 1000565.METUNv1_01987 7.29e-73 237.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KXW1@206389|Rhodocyclales 206389|Rhodocyclales K GAF domain - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_359988_1 1000565.METUNv1_02467 0.0 946.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,2KVPX@206389|Rhodocyclales 206389|Rhodocyclales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_109550_1 1000565.METUNv1_02818 3.23e-170 488.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,2KVHB@206389|Rhodocyclales 206389|Rhodocyclales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_182147_1 1123504.JQKD01000022_gene120 5.69e-68 214.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,4ADGM@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM peptidase S16 lon domain protein - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_432052_1 1049564.TevJSym_ad00030 2.97e-69 219.0 COG1216@1|root,COG1216@2|Bacteria,1R6SJ@1224|Proteobacteria,1RQQW@1236|Gammaproteobacteria,1J82R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyl transferase family group 2 - - - - - - - - - - - - Glycos_transf_2 k59_1001820_1 1000565.METUNv1_02362 9.06e-84 266.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales 206389|Rhodocyclales T Type IV pili methyl-accepting chemotaxis transducer N-term - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3,PilJ k59_646353_1 1000565.METUNv1_01855 3.18e-65 212.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUPC@206389|Rhodocyclales 206389|Rhodocyclales T COG2202 FOG PAS PAC domain - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_646353_2 1000565.METUNv1_01854 5.13e-302 841.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,2KUU4@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_573288_1 1000565.METUNv1_01629 3.21e-144 426.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VQDF@28216|Betaproteobacteria,2KW3G@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_573288_2 395495.Lcho_1091 3.71e-38 135.0 2DWJM@1|root,340P1@2|Bacteria,1NZ41@1224|Proteobacteria,2W3SP@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_252884_1 1538295.JY96_18775 1.44e-73 240.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VKXT@28216|Betaproteobacteria,1KJ5Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria KT Domain present in phytochromes and cGMP-specific phosphodiesterases. nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_325054_1 1000565.METUNv1_02080 2.22e-116 340.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,2KUJE@206389|Rhodocyclales 206389|Rhodocyclales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_325054_2 1000565.METUNv1_02081 1.23e-19 87.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,2KVNS@206389|Rhodocyclales 206389|Rhodocyclales I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_109578_1 903818.KI912268_gene1435 7.17e-75 235.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,3Y4JU@57723|Acidobacteria 57723|Acidobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR,SelR k59_1038081_1 1000565.METUNv1_00990 3.86e-99 294.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2VH12@28216|Betaproteobacteria,2KW6D@206389|Rhodocyclales 206389|Rhodocyclales P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - - - - - - - - - - BPD_transp_1 k59_252902_2 1538295.JY96_16625 6.08e-33 122.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,1KKEX@119065|unclassified Burkholderiales 28216|Betaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_858893_1 371731.Rsw2DRAFT_2843 1.37e-53 176.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,1FB87@1060|Rhodobacter 28211|Alphaproteobacteria E PFAM Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03013,R03243,R03457 RC00006,RC00017,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 - - - IGPD k59_1054009_1 666681.M301_1986 6.88e-85 261.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_669564_1 1168065.DOK_01179 9.46e-79 248.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1J5AP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0417 Anth_synt_I_N,Chorismate_bind k59_669564_2 216142.LT40_18475 2.44e-45 150.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH anthranilate synthase pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_693181_1 338969.Rfer_2447 5.71e-100 300.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,4AB8Z@80864|Comamonadaceae 28216|Betaproteobacteria P Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_304761_1 1198452.Jab_1c25730 3.35e-100 301.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,472MG@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_584474_1 338969.Rfer_3430 8.37e-81 257.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,4AA27@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_226974_1 1458275.AZ34_06180 6.36e-102 318.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_526280_1 1502770.JQMG01000001_gene2394 1.6e-23 103.0 2BHT9@1|root,32BWX@2|Bacteria,1P5DH@1224|Proteobacteria,2W560@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_204419_1 1122951.ATUE01000012_gene514 5.1e-26 101.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,3NIPW@468|Moraxellaceae 1236|Gammaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_204419_2 1177154.Y5S_03752 1.36e-38 133.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1XJFF@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_375524_1 700598.Niako_3759 1.33e-74 237.0 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,1IQJ7@117747|Sphingobacteriia 976|Bacteroidetes P PFAM sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_375524_2 1122605.KB893644_gene1444 7.65e-22 94.0 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,1IQJ7@117747|Sphingobacteriia 976|Bacteroidetes P PFAM sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_803359_1 1131553.JIBI01000070_gene1900 2.22e-56 197.0 COG1816@1|root,COG1816@2|Bacteria,1R6Q8@1224|Proteobacteria,2VNY0@28216|Betaproteobacteria 28216|Betaproteobacteria F Adenosine/AMP deaminase - - 3.5.4.4 ko:K19572 ko00230,ko01100,map00230,map01100 - R01560 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_267637_1 596154.Alide2_3903 1.56e-48 180.0 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_267637_2 748247.AZKH_0338 3.7e-40 140.0 COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,2VI4N@28216|Betaproteobacteria,2KZCZ@206389|Rhodocyclales 206389|Rhodocyclales O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_941743_1 296591.Bpro_3276 2.59e-94 297.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,4AA8E@80864|Comamonadaceae 28216|Betaproteobacteria C nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein nirB - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_908923_1 296591.Bpro_3650 1.67e-100 299.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,4AAUT@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_123313_1 1120968.AUBX01000014_gene2635 4.91e-27 107.0 COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,47KYF@768503|Cytophagia 976|Bacteroidetes S PFAM ABC transporter natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_123313_2 1046627.BZARG_1443 4.69e-05 51.2 COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,4NJ39@976|Bacteroidetes,1HZRK@117743|Flavobacteriia 976|Bacteroidetes L endonuclease I - - - - - - - - - - - - BNR_assoc_N,Beta_helix,DUF4465 k59_52738_1 29581.BW37_02756 3.56e-54 177.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2VIR5@28216|Betaproteobacteria,4724N@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1016232_2 1000565.METUNv1_00987 2.28e-56 186.0 COG1960@1|root,COG1960@2|Bacteria,1NDQ8@1224|Proteobacteria,2WGB5@28216|Betaproteobacteria,2KX0F@206389|Rhodocyclales 206389|Rhodocyclales I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_N k59_481497_1 232721.Ajs_3012 6.98e-61 210.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2VGZW@28216|Betaproteobacteria,4ACYR@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM exopolysaccharide transport protein family - - - ko:K16554,ko:K16692 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,Wzz k59_1121092_1 640081.Dsui_1257 1.98e-36 137.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,2KUJ2@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1121092_2 1121035.AUCH01000005_gene117 9.08e-34 123.0 COG0784@1|root,COG0784@2|Bacteria,1QWFW@1224|Proteobacteria,2VPCN@28216|Betaproteobacteria,2KVZ3@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_551480_1 1283300.ATXB01000001_gene2267 4.15e-09 56.6 COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,1RPWA@1236|Gammaproteobacteria,1XDKA@135618|Methylococcales 135618|Methylococcales D 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_551480_2 653733.Selin_2501 1.61e-51 176.0 COG0415@1|root,COG0415@2|Bacteria 2|Bacteria L Belongs to the DNA photolyase family phrB GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_16360_1 1348657.M622_12865 1.28e-88 278.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VHAI@28216|Betaproteobacteria,2KV9D@206389|Rhodocyclales 28216|Betaproteobacteria L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_730012_1 1177179.A11A3_15197 7.47e-29 110.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1T042@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_52761_1 903818.KI912268_gene893 1.8e-84 278.0 COG1038@1|root,COG1038@2|Bacteria,3Y6UX@57723|Acidobacteria 57723|Acidobacteria C Conserved carboxylase domain - - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_908981_2 1286631.X805_15030 1.48e-34 123.0 2EGU1@1|root,33AK7@2|Bacteria,1NJ8J@1224|Proteobacteria,2W5BQ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_730026_1 316055.RPE_3198 1.44e-84 261.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria,3JYK9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S SBF-like CPA transporter family (DUF4137) - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1091903_1 1000565.METUNv1_00550 4.07e-120 370.0 COG4733@1|root,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,2VQCZ@28216|Betaproteobacteria 28216|Betaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_693323_1 83406.HDN1F_01720 6.52e-62 196.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1J5SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212 Ham1p_like k59_618804_1 1000565.METUNv1_01868 4.28e-159 461.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,2KUNY@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_227081_1 398579.Spea_3006 6.61e-56 196.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8P9@267890|Shewanellaceae 1236|Gammaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,PAS,PAS_3,PAS_9,dCache_1 k59_159614_1 929712.KI912613_gene1050 8.11e-06 47.8 COG0054@1|root,COG0054@2|Bacteria,2IJU6@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH2 - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_908996_1 640081.Dsui_1276 4.15e-43 145.0 COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,2KWXG@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial SH3 domain - - - - - - - - - - - - SH3_4 k59_908996_2 1005048.CFU_4059 2.14e-11 63.9 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,472MZ@75682|Oxalobacteraceae 28216|Betaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_669801_1 398578.Daci_4763 7.49e-91 293.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_978726_1 1000565.METUNv1_02513 2.87e-116 343.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,2KU8K@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_408415_1 688245.CtCNB1_0139 6.84e-49 167.0 COG0577@1|root,COG0577@2|Bacteria,1PKX0@1224|Proteobacteria,2VIW0@28216|Betaproteobacteria,4A9V7@80864|Comamonadaceae 28216|Betaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - - k59_123407_1 1000565.METUNv1_01943 6.88e-126 379.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales 206389|Rhodocyclales U Type 4 fimbrial biogenesis protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_267763_2 1353529.M899_2839 6.13e-24 96.7 COG4123@1|root,COG4123@2|Bacteria,1RKDM@1224|Proteobacteria,437GT@68525|delta/epsilon subdivisions,2MT0I@213481|Bdellovibrionales,2XA42@28221|Deltaproteobacteria 213481|Bdellovibrionales S Conserved hypothetical protein 95 - - - - - - - - - - - - - k59_16410_1 497964.CfE428DRAFT_1789 3.26e-80 252.0 COG0195@1|root,COG0195@2|Bacteria,46TRP@74201|Verrucomicrobia 74201|Verrucomicrobia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_941844_2 398578.Daci_1953 9.38e-61 202.0 28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_873228_1 1198452.Jab_1c23660 4.83e-29 113.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,47399@75682|Oxalobacteraceae 28216|Betaproteobacteria S DinB superfamily egtB - - - - - - - - - - - DinB_2,FGE-sulfatase k59_873228_2 29581.BW37_04691 1.41e-56 186.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,473AH@75682|Oxalobacteraceae 28216|Betaproteobacteria S Histidine-specific methyltransferase, SAM-dependent egtD - - - - - - - - - - - Methyltransf_33 k59_408439_1 404589.Anae109_1930 7.46e-11 62.8 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,42SRC@68525|delta/epsilon subdivisions,2WQQ4@28221|Deltaproteobacteria,2YVK2@29|Myxococcales 28221|Deltaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_408439_2 1480694.DC28_14260 1.49e-53 181.0 COG0201@1|root,COG0201@2|Bacteria,2J5BH@203691|Spirochaetes 203691|Spirochaetes U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_304988_1 85643.Tmz1t_1820 1.28e-40 141.0 2C80Q@1|root,30ICB@2|Bacteria,1N35V@1224|Proteobacteria,2VVGE@28216|Betaproteobacteria,2KWJ6@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_304988_2 640081.Dsui_3128 4.95e-16 77.8 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_123441_1 375286.mma_2206 5.94e-41 148.0 COG5323@1|root,COG5323@2|Bacteria 2|Bacteria M Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_483164_1 925409.KI911562_gene244 2.41e-26 107.0 COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,1IR7T@117747|Sphingobacteriia 976|Bacteroidetes S coagulation factor 5 8 type - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 k59_483164_2 525257.HMPREF0204_13287 1.01e-26 107.0 COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,1HZCR@117743|Flavobacteriia,3ZPXT@59732|Chryseobacterium 976|Bacteroidetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_672084_1 1336208.JADY01000002_gene424 1.72e-16 84.7 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2JQVC@204441|Rhodospirillales 204441|Rhodospirillales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_585771_1 1121033.AUCF01000011_gene1752 1.72e-15 78.6 COG2230@1|root,COG2230@2|Bacteria,1RJ4C@1224|Proteobacteria,2UA2C@28211|Alphaproteobacteria,2JSVC@204441|Rhodospirillales 204441|Rhodospirillales M cyclopropane-fatty-acyl-phospholipid synthase - - - - - - - - - - - - Methyltransf_23 k59_528871_1 159087.Daro_0486 2.55e-56 178.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,2KW34@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_528871_2 159087.Daro_0485 7.95e-61 204.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KUQJ@206389|Rhodocyclales 206389|Rhodocyclales P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_528875_1 1120977.JHUX01000008_gene498 2.85e-73 228.0 COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,1RQZZ@1236|Gammaproteobacteria,3NIJK@468|Moraxellaceae 1236|Gammaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain rstA - - ko:K07661 ko02020,map02020 M00446 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1122276_1 663610.JQKO01000010_gene2216 5.69e-60 195.0 COG0730@1|root,COG0730@2|Bacteria,1RCVI@1224|Proteobacteria,2U5XM@28211|Alphaproteobacteria,3NC09@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE MA20_18170 - - ko:K07090 - - - - ko00000 - - - TauE k59_457526_1 1223521.BBJX01000001_gene1024 1.35e-84 275.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,4AAE2@80864|Comamonadaceae 28216|Betaproteobacteria L DNA topoisomerase, type IA, central domain protein topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_409714_1 1307437.J139_13445 1.03e-47 175.0 COG0584@1|root,COG0737@1|root,COG0584@2|Bacteria,COG0737@2|Bacteria,1NTU5@1224|Proteobacteria,1RR0F@1236|Gammaproteobacteria,2Q04P@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria CF Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_694769_1 159087.Daro_1934 1.94e-68 233.0 COG0784@1|root,COG3290@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1 k59_89115_1 1122951.ATUE01000007_gene819 1.01e-62 215.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,3NIHA@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECs_1301.ECs5024,iG2583_1286.G2583_4866 Acyltransferase k59_980143_1 1121022.ABENE_04845 1e-65 216.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_5 k59_980143_2 395961.Cyan7425_2181 7.78e-83 262.0 28M8R@1|root,2ZAMU@2|Bacteria,1G3XB@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_980143_3 1266925.JHVX01000012_gene1753 1.83e-67 213.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,373RD@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Transposase, IS4-like - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_350073_1 1000565.METUNv1_03060 8.47e-94 285.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KUP7@206389|Rhodocyclales 206389|Rhodocyclales LU Rossmann fold nucleotide-binding protein involved in DNA uptake - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_839671_1 614083.AWQR01000011_gene2353 5.63e-91 271.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,4AAT4@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM ABC transporter related lolD - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_839671_2 887898.HMPREF0551_0707 6.26e-26 102.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2VRIQ@28216|Betaproteobacteria,1K41R@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM lipolytic protein G-D-S-L family tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_528921_1 760117.JN27_17985 2.81e-44 147.0 COG0662@1|root,COG0662@2|Bacteria,1NB9H@1224|Proteobacteria,2VWHR@28216|Betaproteobacteria,47872@75682|Oxalobacteraceae 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_306769_1 266265.Bxe_A0921 1.72e-10 60.8 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2VUG3@28216|Betaproteobacteria,1K72W@119060|Burkholderiaceae 28216|Betaproteobacteria K Addiction module antidote protein, HigA - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_1130873_1 1198452.Jab_1c20820 6.83e-77 250.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria,478GF@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_417661_1 640081.Dsui_2409 2.03e-121 357.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,2KU64@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_1070208_1 983917.RGE_33480 8.98e-105 335.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2VI5I@28216|Betaproteobacteria 28216|Betaproteobacteria H cobalamin biosynthesis protein CobN bchH - 6.6.1.1 ko:K03403 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - CobN-Mg_chel,DUF3479 k59_389805_1 614083.AWQR01000018_gene1761 1.52e-98 306.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,4AAN3@80864|Comamonadaceae 28216|Betaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_26536_1 338969.Rfer_0920 1.25e-86 268.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AHD6@80864|Comamonadaceae 28216|Betaproteobacteria M Penicillin-binding protein 5, C-terminal domain dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_235745_1 1157708.KB907459_gene2077 2.09e-80 247.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,4AAVN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_235745_2 232721.Ajs_0495 1.7e-24 94.4 COG1539@1|root,COG1539@2|Bacteria,1RD8Q@1224|Proteobacteria,2VR6E@28216|Betaproteobacteria,4ADXQ@80864|Comamonadaceae 28216|Betaproteobacteria H dihydroneopterin aldolase - - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_772250_1 498211.CJA_2438 1.72e-55 187.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1FH36@10|Cellvibrio 1236|Gammaproteobacteria J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_950583_1 159087.Daro_2105 8.52e-31 124.0 COG0642@1|root,COG0784@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527,ko:K20973 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_317982_1 452863.Achl_3622 5.81e-38 140.0 COG2066@1|root,COG2066@2|Bacteria,2GKAV@201174|Actinobacteria,1W7RU@1268|Micrococcaceae 201174|Actinobacteria E Belongs to the glutaminase family glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - AHSA1,Glutaminase,STAS k59_563572_1 376686.Fjoh_0346 1.97e-24 102.0 2CYX9@1|root,32T52@2|Bacteria,4P2NU@976|Bacteroidetes,1I8YF@117743|Flavobacteriia 976|Bacteroidetes S WavE lipopolysaccharide synthesis - - - - - - - - - - - - WavE k59_417709_1 1177179.A11A3_03319 1.44e-83 267.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XHJZ@135619|Oceanospirillales 135619|Oceanospirillales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_850166_1 1198452.Jab_1c17190 3.88e-109 323.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2VP73@28216|Betaproteobacteria,477P7@75682|Oxalobacteraceae 28216|Betaproteobacteria U ABC-type sugar ugpA_1 - - ko:K02025,ko:K05814,ko:K10118,ko:K17242,ko:K17245 ko02010,map02010 M00196,M00198,M00207,M00600,M00601 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28,3.A.1.1.3,3.A.1.1.39,3.A.1.1.40 - - BPD_transp_1 k59_1130923_1 1000565.METUNv1_02812 7.1e-54 183.0 COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria,2KYFR@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c k59_1130923_2 1000565.METUNv1_02813 9.93e-34 122.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,2KVPH@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_739412_1 1268622.AVS7_00965 1.93e-25 99.0 COG0664@1|root,COG0664@2|Bacteria,1RFGF@1224|Proteobacteria,2VR2U@28216|Betaproteobacteria,4AE8C@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_739412_2 1123255.JHYS01000002_gene2377 2.92e-14 73.9 2CGAU@1|root,30291@2|Bacteria,1RE86@1224|Proteobacteria,2VRJV@28216|Betaproteobacteria,4AE95@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_493846_1 266265.Bxe_A0998 2.08e-113 331.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,1K18X@119060|Burkholderiaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_493846_2 1304883.KI912532_gene510 9.96e-42 147.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2VIF1@28216|Betaproteobacteria,2KUN6@206389|Rhodocyclales 206389|Rhodocyclales C acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_389863_1 1500894.JQNN01000001_gene347 3.63e-06 47.8 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_389863_2 760117.JN27_21155 4.22e-20 92.8 COG2244@1|root,COG2244@2|Bacteria,1R6ME@1224|Proteobacteria,2VNGZ@28216|Betaproteobacteria,4753X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Polysaccharide biosynthesis protein rfbE - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_417729_2 1300345.LF41_2378 6.86e-30 108.0 2ADF5@1|root,31358@2|Bacteria,1QCUI@1224|Proteobacteria,1T8MP@1236|Gammaproteobacteria,1XAY4@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_417729_3 670292.JH26_14425 1.68e-77 238.0 2DIG9@1|root,3036R@2|Bacteria,1RBPA@1224|Proteobacteria,2U6EP@28211|Alphaproteobacteria,1JV25@119045|Methylobacteriaceae 28211|Alphaproteobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_1027736_1 338969.Rfer_0245 1.47e-24 99.8 COG2010@1|root,COG2010@2|Bacteria,1QYUH@1224|Proteobacteria 1224|Proteobacteria C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_1027736_2 983917.RGE_22140 6.2e-72 238.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_885135_1 1120968.AUBX01000003_gene3388 1.41e-15 77.8 COG2515@1|root,COG2515@2|Bacteria,4NEP9@976|Bacteroidetes,47JNZ@768503|Cytophagia 976|Bacteroidetes E 1-aminocyclopropane-1-carboxylate deaminase acdS - 3.5.99.7 ko:K01505 ko00270,map00270 - R00997 RC00419 ko00000,ko00001,ko01000 - - - PALP k59_626484_1 765914.ThisiDRAFT_2674 3.01e-29 122.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WWX0@135613|Chromatiales 135613|Chromatiales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_739440_1 1122621.ATZA01000012_gene3076 2.23e-62 216.0 COG0793@1|root,COG3391@1|root,COG4946@1|root,COG0793@2|Bacteria,COG3391@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IRKC@117747|Sphingobacteriia 976|Bacteroidetes M Tricorn protease homolog - - - - - - - - - - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_812905_2 1038869.AXAN01000027_gene2400 1.01e-123 362.0 COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2VP1G@28216|Betaproteobacteria,1K3C0@119060|Burkholderiaceae 28216|Betaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_772296_1 338969.Rfer_2577 7.59e-22 88.6 COG3609@1|root,COG3609@2|Bacteria,1RHNZ@1224|Proteobacteria,2VSYD@28216|Betaproteobacteria,4AEMF@80864|Comamonadaceae 28216|Betaproteobacteria K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - - - - - - - - - - - k59_134011_1 1266908.AQPB01000053_gene554 3.35e-53 187.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1WWFC@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_134011_2 1038858.AXBA01000027_gene1379 0.000143 43.5 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,3EXUS@335928|Xanthobacteraceae 28211|Alphaproteobacteria C BFD domain protein 2Fe-2S -binding domain protein nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_417746_1 1122194.AUHU01000021_gene3476 1.92e-122 385.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,46403@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_563613_1 93220.LV28_24815 5.84e-06 47.8 COG3299@1|root,COG3299@2|Bacteria,1MXKB@1224|Proteobacteria,2VNZ9@28216|Betaproteobacteria,1K39C@119060|Burkholderiaceae 28216|Betaproteobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_563613_2 1144342.PMI40_00846 3.49e-88 266.0 28XAN@1|root,2ZJ8N@2|Bacteria,1RAE9@1224|Proteobacteria,2VSKB@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_991238_2 106648.BBLJ01000007_gene397 3.47e-14 72.8 2A78P@1|root,30W55@2|Bacteria,1RGCT@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_101708_1 640081.Dsui_1564 7.16e-60 209.0 COG4191@1|root,COG5000@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV2U@206389|Rhodocyclales 206389|Rhodocyclales T PAS fold - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_7,PAS_8,PAS_9 k59_628203_1 202956.BBNL01000031_gene180 1.35e-14 69.7 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,3NIEQ@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0380 DMRL_synthase k59_628203_2 1122951.ATUE01000005_gene2160 1.53e-53 172.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,3NIY0@468|Moraxellaceae 1236|Gammaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_628203_3 1221522.B723_28505 1.29e-20 90.1 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1YPHU@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C k59_888671_1 1454004.AW11_00493 1.1e-71 224.0 COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VJA3@28216|Betaproteobacteria,1KQ4A@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_888671_2 1121033.AUCF01000032_gene2633 0.000393 42.7 COG0589@1|root,COG0589@2|Bacteria,1RG30@1224|Proteobacteria,2U7DC@28211|Alphaproteobacteria,2JRXD@204441|Rhodospirillales 204441|Rhodospirillales T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_628211_1 29581.BW37_05507 6.16e-111 347.0 COG1629@1|root,COG4771@2|Bacteria,1MW4X@1224|Proteobacteria,2WBPM@28216|Betaproteobacteria,47684@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarboxypepD_reg,Plug k59_281199_2 883126.HMPREF9710_03978 8.01e-43 153.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,4734Y@75682|Oxalobacteraceae 28216|Betaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1100217_1 688245.CtCNB1_1313 1.62e-89 270.0 COG0491@1|root,COG0491@2|Bacteria,1NGQE@1224|Proteobacteria,2VH3G@28216|Betaproteobacteria,4AAP0@80864|Comamonadaceae 28216|Betaproteobacteria S beta-lactamase - - - - - - - - - - - - Lactamase_B k59_1100217_2 399795.CtesDRAFT_PD3687 6.91e-15 72.0 COG3531@1|root,COG3531@2|Bacteria,1RA76@1224|Proteobacteria,2VQ3R@28216|Betaproteobacteria,4ADR6@80864|Comamonadaceae 28216|Betaproteobacteria O Protein-disulfide isomerase - - - ko:K07396 - - - - ko00000 - - - DSBA k59_774637_1 1122197.ATWI01000008_gene3353 2.86e-11 65.9 COG2199@1|root,COG3706@2|Bacteria,1R76U@1224|Proteobacteria,1S15R@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg k59_497238_1 411471.SUBVAR_05673 1.19e-06 52.4 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,3WGMQ@541000|Ruminococcaceae 186801|Clostridia C hydrogenase large subunit hydC - 1.12.1.3,1.6.5.3 ko:K00336,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_497238_2 1396141.BATP01000061_gene4518 1.74e-16 80.1 COG1894@1|root,COG1894@2|Bacteria,46S8J@74201|Verrucomicrobia,2ITYB@203494|Verrucomicrobiae 203494|Verrucomicrobiae C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_853286_1 1000565.METUNv1_01920 4.23e-19 82.4 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2VQ1Z@28216|Betaproteobacteria,2KVRN@206389|Rhodocyclales 206389|Rhodocyclales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_853286_2 1000565.METUNv1_01919 2.51e-131 383.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,2KUR1@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_320719_1 402881.Plav_2107 3.19e-41 145.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,1JN30@119043|Rhodobiaceae 28211|Alphaproteobacteria G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_320719_2 1121033.AUCF01000041_gene475 3.87e-22 94.7 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2JPG1@204441|Rhodospirillales 204441|Rhodospirillales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_888729_2 1000565.METUNv1_02461 3.92e-108 329.0 COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,2KUDR@206389|Rhodocyclales 206389|Rhodocyclales S CHAD domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHAD,CYTH k59_991307_1 1267211.KI669560_gene702 8.87e-36 135.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1INNS@117747|Sphingobacteriia 976|Bacteroidetes M mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_991308_1 983917.RGE_39640 4.08e-48 174.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KJEE@119065|unclassified Burkholderiales 28216|Betaproteobacteria T GGDEF domain - - - - - - - - - - - - CHASE,EAL,GAF_2,GGDEF,PAS_4,PAS_9 k59_774679_1 748247.AZKH_0340 1.47e-14 75.9 COG3391@1|root,COG3391@2|Bacteria,1MYI5@1224|Proteobacteria,2VNCM@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM NHL repeat containing protein - - - - - - - - - - - - - k59_815133_2 883126.HMPREF9710_01934 3.07e-19 89.7 COG0727@1|root,COG0727@2|Bacteria,1N9E6@1224|Proteobacteria,2W3TG@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Uncharacterised protein family (UPF0153) - - - - - - - - - - - - - k59_920596_1 324925.Ppha_0350 1.33e-108 327.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_173019_1 640081.Dsui_1234 1.03e-96 298.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KUV1@206389|Rhodocyclales 206389|Rhodocyclales S modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_65408_1 873513.HMPREF6485_2797 1.38e-36 139.0 COG4591@1|root,COG4591@2|Bacteria,4NFWZ@976|Bacteroidetes,2FMHC@200643|Bacteroidia 976|Bacteroidetes M Efflux ABC transporter, permease protein lolE_1 - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_281276_1 224911.27354704 1.84e-19 86.7 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,3JUPZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CH FAD binding domain nah - 1.14.13.1 ko:K00480 ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220 - R00818,R05632,R06915,R06936,R06939 RC00389 ko00000,ko00001,ko01000 - - - FAD_binding_3,NAD_binding_8 k59_281276_2 658612.MD26_21220 1.09e-26 103.0 COG2146@1|root,COG2146@2|Bacteria 2|Bacteria P nitrite reductase [NAD(P)H] activity - - 2.7.1.3 ko:K00846,ko:K05710 ko00051,ko00360,ko01100,ko01120,ko01220,map00051,map00360,map01100,map01120,map01220 M00545 R00866,R03819,R06782,R06783 RC00002,RC00017,RC00098,RC00608 br01602,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Rieske k59_65413_1 1198452.Jab_1c15110 3.71e-101 320.0 COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,4768K@75682|Oxalobacteraceae 28216|Betaproteobacteria M Transglycosylase - - - - - - - - - - - - Transgly,Transpeptidase k59_173032_1 1123401.JHYQ01000022_gene1110 5.84e-16 78.2 COG1309@1|root,COG1309@2|Bacteria,1NBKX@1224|Proteobacteria,1S7KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_320775_1 570967.JMLV01000004_gene509 2.9e-06 48.1 COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,2U5PV@28211|Alphaproteobacteria,2JU2N@204441|Rhodospirillales 204441|Rhodospirillales M Cytidylyltransferase - - 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 - R01117,R04215 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3 k59_238228_1 85643.Tmz1t_3762 6.86e-17 87.8 COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1P8N9@1224|Proteobacteria,2VMKU@28216|Betaproteobacteria 28216|Betaproteobacteria U Protein conserved in bacteria - - - - - - - - - - - - - k59_595824_1 640081.Dsui_3034 1.3e-37 140.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_595824_2 887062.HGR_09324 7.21e-70 219.0 COG3221@1|root,COG3221@2|Bacteria,1PUJG@1224|Proteobacteria,2VKHU@28216|Betaproteobacteria,4AJM3@80864|Comamonadaceae 28216|Betaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_815195_1 1266925.JHVX01000005_gene1993 3.65e-51 184.0 COG3934@1|root,COG3934@2|Bacteria,1R8MX@1224|Proteobacteria,2VZJ5@28216|Betaproteobacteria 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - Cellulase k59_742800_1 755732.Fluta_3104 7.6e-48 174.0 COG3291@1|root,COG3291@2|Bacteria,4PI0I@976|Bacteroidetes,1I5WG@117743|Flavobacteriia,2PBH4@246874|Cryomorphaceae 2|Bacteria S C-terminal domain of CHU protein family - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - CHU_C,PKD,Peptidase_M43,SprB k59_566262_1 1000565.METUNv1_02360 8.79e-59 196.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VJYJ@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator norR - - ko:K02584,ko:K12266 ko02020,ko05132,map02020,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_566262_2 1114970.PSF113_3765 2.75e-16 77.4 COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,1RPY6@1236|Gammaproteobacteria,1YSMZ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria D Di-iron-containing protein involved in the repair of iron-sulfur clusters ytfE GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564 - ko:K07322 - - - - ko00000 - - iECED1_1282.ECED1_5068,iECH74115_1262.ECH74115_5726,iECSP_1301.ECSP_5311,iECs_1301.ECs5187,iG2583_1286.G2583_5039,iZ_1308.Z5820 Hemerythrin,ScdA_N k59_991388_1 391735.Veis_4871 3.92e-14 72.4 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,4ACIR@80864|Comamonadaceae 28216|Betaproteobacteria NU pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM k59_991388_2 391735.Veis_4870 1.45e-65 207.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,4AA8B@80864|Comamonadaceae 28216|Betaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_815201_1 1122951.ATUE01000013_gene1517 7.65e-127 374.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,3NIRD@468|Moraxellaceae 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_29197_1 640081.Dsui_2841 8.78e-166 475.0 COG0641@1|root,COG0641@2|Bacteria,1NG2E@1224|Proteobacteria,2VMIE@28216|Betaproteobacteria,2KZTI@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_920664_1 1229205.BUPH_05280 1.06e-33 130.0 2ES2P@1|root,33JMP@2|Bacteria,1NGYH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_420303_2 1122599.AUGR01000019_gene3101 0.000115 47.0 COG5566@1|root,COG5566@2|Bacteria,1N84Q@1224|Proteobacteria,1SE3S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mor transcription activator family - - - - - - - - - - - - Mor k59_420303_3 1027273.GZ77_21175 9.85e-12 66.6 2CESS@1|root,33C6B@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_23 k59_420303_4 686340.Metal_2706 7.1e-27 102.0 2EQ8V@1|root,33HV2@2|Bacteria,1NK9Y@1224|Proteobacteria,1SH3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_420303_5 666685.R2APBS1_2161 7.84e-20 82.8 COG1724@1|root,COG1724@2|Bacteria 2|Bacteria N mRNA binding - - - - - - - - - - - - HicA_toxin k59_238253_1 94624.Bpet2884 8.02e-121 365.0 COG4983@1|root,COG4983@2|Bacteria 2|Bacteria L Phage plasmid primase, P4 family domain protein - - - - - - - - - - - - AAA_25,DUF3987,Prim-Pol k59_817938_1 83406.HDN1F_29300 2.49e-91 279.0 2C777@1|root,33R3E@2|Bacteria,1NT4D@1224|Proteobacteria,1SM29@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF900 k59_422935_1 1121887.AUDK01000002_gene2159 8.63e-72 240.0 COG3250@1|root,COG3250@2|Bacteria,4NF4T@976|Bacteroidetes,1HZ5Y@117743|Flavobacteriia,2NV6D@237|Flavobacterium 976|Bacteroidetes G Glycosyl hydrolases family 2 - - - - - - - - - - - - Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_746246_1 1235457.C404_23070 3.19e-49 172.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_241009_2 700598.Niako_2543 6.47e-53 179.0 COG0044@1|root,COG0044@2|Bacteria,4NDUZ@976|Bacteroidetes,1IRB4@117747|Sphingobacteriia 976|Bacteroidetes F Dihydroorotase, multifunctional complex type pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_241014_1 1198452.Jab_2c30240 2.08e-10 60.5 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2VK3E@28216|Betaproteobacteria,473BZ@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_993910_1 338969.Rfer_1989 2.09e-85 256.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,4AATW@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1034046_1 1122605.KB893626_gene2424 2.31e-22 97.1 COG0671@1|root,COG0671@2|Bacteria,4NUPJ@976|Bacteroidetes,1IUI6@117747|Sphingobacteriia 976|Bacteroidetes I phosphoesterase, PA-phosphatase related - - - - - - - - - - - - - k59_1136849_1 1123487.KB892835_gene3464 4.48e-39 145.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,2KYBZ@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_241038_1 504472.Slin_5536 1.61e-53 172.0 COG0454@1|root,COG0456@2|Bacteria,4NQDY@976|Bacteroidetes,47QNQ@768503|Cytophagia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_892251_1 202952.BBLI01000039_gene2581 2.26e-64 206.0 COG3271@1|root,COG3271@2|Bacteria,1R9HR@1224|Proteobacteria,1RYUR@1236|Gammaproteobacteria,3NJZ5@468|Moraxellaceae 1236|Gammaproteobacteria S Peptidase C39 family - - - ko:K06992 - - - - ko00000 - - - Peptidase_C39 k59_955252_1 1165096.ARWF01000001_gene3 1.88e-31 127.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KNG7@206350|Nitrosomonadales 206350|Nitrosomonadales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_598374_1 640081.Dsui_1971 5.1e-47 162.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,2VIUT@28216|Betaproteobacteria,2KUKV@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_598374_2 1304883.KI912532_gene2195 2.56e-27 109.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2VJGZ@28216|Betaproteobacteria,2KVBT@206389|Rhodocyclales 206389|Rhodocyclales M lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_176280_1 497321.C664_14044 3.19e-65 211.0 COG1879@1|root,COG1879@2|Bacteria,1R8HF@1224|Proteobacteria,2VM7A@28216|Betaproteobacteria,2KXJ7@206389|Rhodocyclales 206389|Rhodocyclales G Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 k59_31869_1 1120977.JHUX01000003_gene684 7.3e-70 221.0 COG1073@1|root,COG1073@2|Bacteria,1MUIK@1224|Proteobacteria,1S0U4@1236|Gammaproteobacteria,3NIJF@468|Moraxellaceae 1236|Gammaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_923315_1 402777.KB235903_gene417 1.56e-17 87.8 COG4191@1|root,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H7H2@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA k59_241092_1 614083.AWQR01000009_gene539 2e-26 105.0 COG0583@1|root,COG0583@2|Bacteria,1Q6E2@1224|Proteobacteria,2VMC3@28216|Betaproteobacteria,4AA0Y@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator gbpR - - - - - - - - - - - HTH_1,LysR_substrate k59_241092_2 614083.AWQR01000009_gene540 1.66e-54 176.0 COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2VJQ7@28216|Betaproteobacteria,4AA03@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.175 ko:K22185 ko00040,map00040 - R01429 RC00066 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_634678_1 287.DR97_3132 1.06e-33 134.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1YFMH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). aer2 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,HAMP,MCPsignal,NIT,PAS_3,PAS_4,PAS_8,PAS_9 k59_927940_1 583355.Caka_2479 1.45e-27 111.0 COG0451@1|root,COG0451@2|Bacteria,46UBJ@74201|Verrucomicrobia,3K7JK@414999|Opitutae 414999|Opitutae M 3-beta hydroxysteroid dehydrogenase - - 1.1.1.412 ko:K22320 - - - - ko00000,ko01000 - - - 3Beta_HSD k59_999300_1 296591.Bpro_2928 4.07e-69 214.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VKFG@28216|Betaproteobacteria,4ACG4@80864|Comamonadaceae 28216|Betaproteobacteria K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_783048_1 358220.C380_21605 9.63e-21 87.4 COG4314@1|root,COG4314@2|Bacteria,1N3VH@1224|Proteobacteria,2VVED@28216|Betaproteobacteria,4AEZ6@80864|Comamonadaceae 28216|Betaproteobacteria C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - k59_927954_1 614083.AWQR01000003_gene2928 3.26e-51 162.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,4AEXW@80864|Comamonadaceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_927954_2 614083.AWQR01000003_gene2927 4.55e-33 115.0 2E860@1|root,33BGB@2|Bacteria,1NGBB@1224|Proteobacteria,2VXKZ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_603373_1 614083.AWQR01000030_gene2823 9.16e-122 363.0 COG0415@1|root,COG0415@2|Bacteria,1MX6J@1224|Proteobacteria,2VK7R@28216|Betaproteobacteria,4AAD6@80864|Comamonadaceae 28216|Betaproteobacteria L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_603412_1 1301098.PKB_0586 3.69e-09 63.9 29YI9@1|root,30KDD@2|Bacteria,1QPPT@1224|Proteobacteria,1SNZT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_427336_1 1265313.HRUBRA_02087 8.21e-126 372.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_427364_1 1198452.Jab_1c04220 3.33e-71 232.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VIMC@28216|Betaproteobacteria,475NY@75682|Oxalobacteraceae 28216|Betaproteobacteria T Signal transduction histidine kinase regulating C4-dicarboxylate transport system dctB - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_783221_1 1278073.MYSTI_01781 9.89e-43 159.0 COG2312@1|root,COG2312@2|Bacteria,1NEZB@1224|Proteobacteria,433VP@68525|delta/epsilon subdivisions,2X3PC@28221|Deltaproteobacteria,2YWR8@29|Myxococcales 28221|Deltaproteobacteria S Erythromycin esterase - - - ko:K06880 - - - - ko00000,ko01000,ko01504 - - - CarboxypepD_reg,Erythro_esteras k59_634887_1 883126.HMPREF9710_00404 3.75e-64 196.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,4748W@75682|Oxalobacteraceae 28216|Betaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_634887_2 883126.HMPREF9710_00406 3.04e-45 146.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU9X@28216|Betaproteobacteria,474RH@75682|Oxalobacteraceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_783246_1 521011.Mpal_1371 8.99e-49 169.0 COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,2N92C@224756|Methanomicrobia 224756|Methanomicrobia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_783253_1 555778.Hneap_1492 2.92e-48 172.0 COG1216@1|root,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1WX7R@135613|Chromatiales 135613|Chromatiales J PFAM Glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_246544_1 714943.Mucpa_4353 2.31e-104 335.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,1IP5J@117747|Sphingobacteriia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_603669_1 1121920.AUAU01000009_gene1859 8.82e-65 207.0 COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - - k59_960589_1 977880.RALTA_A0539 1.25e-76 254.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K044@119060|Burkholderiaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296,ko:K07788,ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_246605_1 748247.AZKH_3807 3.48e-138 407.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,2KV81@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_427530_1 1240350.AMZE01000100_gene1784 1.56e-24 107.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1YV63@136845|Pseudomonas putida group 1236|Gammaproteobacteria L impB/mucB/samB family imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_783369_1 500640.CIT292_06291 3.21e-86 284.0 COG0846@1|root,COG0846@2|Bacteria,1R92Q@1224|Proteobacteria,1S1CG@1236|Gammaproteobacteria 1236|Gammaproteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_427549_2 264462.Bd2226 5.48e-07 51.2 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2MTHN@213481|Bdellovibrionales,2WIQY@28221|Deltaproteobacteria 213481|Bdellovibrionales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_603801_1 1458275.AZ34_17350 3.27e-109 329.0 COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,2VKBF@28216|Betaproteobacteria,4ABIE@80864|Comamonadaceae 28216|Betaproteobacteria G Extracellular solute-binding protein - - - ko:K17321 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - SBP_bac_1,SBP_bac_8 k59_635068_1 521719.ATXQ01000005_gene1432 6.36e-57 194.0 COG1352@1|root,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,1S1XK@1236|Gammaproteobacteria,1YD6W@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NT Methyltransferase, chemotaxis proteins wspC - 2.1.1.80 ko:K00575,ko:K13486 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N,TPR_8 k59_783443_2 382464.ABSI01000020_gene121 3.26e-42 153.0 COG0500@1|root,COG0500@2|Bacteria,46YTR@74201|Verrucomicrobia,2IU3A@203494|Verrucomicrobiae 203494|Verrucomicrobiae Q methyltransferase - - - - - - - - - - - - Methyltransf_23,Response_reg k59_960823_1 522306.CAP2UW1_0985 8.82e-73 229.0 COG3287@1|root,COG3287@2|Bacteria,1QUQH@1224|Proteobacteria,2VMN2@28216|Betaproteobacteria 28216|Betaproteobacteria S FIST C domain - - - - - - - - - - - - FIST,FIST_C k59_246758_1 1235457.C404_15855 9.79e-10 58.2 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,1K0D6@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_246758_2 395495.Lcho_3589 2.65e-06 50.8 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1KKZ8@119065|unclassified Burkholderiales 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_7,Response_reg k59_246766_1 880071.Fleli_0021 7.15e-16 76.6 COG2870@1|root,COG2870@2|Bacteria,4NHUV@976|Bacteroidetes,47K45@768503|Cytophagia 976|Bacteroidetes M pfkB family carbohydrate kinase rfaE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_246766_2 1121904.ARBP01000004_gene848 1.87e-37 137.0 COG0436@1|root,COG0436@2|Bacteria,4NENS@976|Bacteroidetes,47JJH@768503|Cytophagia 976|Bacteroidetes E PFAM Aminotransferase class I and II aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_603929_1 543728.Vapar_1777 1.28e-32 122.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,4A9W2@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_603929_2 1538295.JY96_00955 4.46e-63 202.0 COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2VJI6@28216|Betaproteobacteria,1KJNV@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Belongs to the ribose-phosphate pyrophosphokinase family - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_427722_1 257313.BP2918 1.47e-09 56.2 COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2VSCM@28216|Betaproteobacteria,3T4M8@506|Alcaligenaceae 28216|Betaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_427722_2 1535422.ND16A_3294 1.28e-15 71.6 2CB3Y@1|root,32WGM@2|Bacteria,1NDA0@1224|Proteobacteria,1SE7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_246818_1 243365.CV_3438 8.53e-32 129.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KQ5R@206351|Neisseriales 206351|Neisseriales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_783592_2 795666.MW7_2319 8.67e-51 168.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2VH6D@28216|Betaproteobacteria,1K4P9@119060|Burkholderiaceae 28216|Betaproteobacteria U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_635211_1 1122951.ATUE01000005_gene1535 4.06e-101 305.0 COG0661@1|root,COG0661@2|Bacteria,1N1UJ@1224|Proteobacteria,1RP1G@1236|Gammaproteobacteria,3NJ0D@468|Moraxellaceae 1236|Gammaproteobacteria S ABC1 family aarF - - - - - - - - - - - ABC1,APH k59_427773_1 535289.Dtpsy_3012 1.55e-95 284.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,4ABCD@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_961028_1 326297.Sama_1362 3.11e-104 311.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,2Q8US@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_246942_1 204773.HEAR2915 0.000407 41.6 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,4735S@75682|Oxalobacteraceae 28216|Betaproteobacteria C Heme copper-type cytochrome quinol oxidase, subunit 3 coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_246942_2 477184.KYC_21961 1.54e-19 81.3 2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2VXNC@28216|Betaproteobacteria,3T4S2@506|Alcaligenaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2970) - - - - - - - - - - - - DUF2970 k59_246942_3 1095769.CAHF01000014_gene2983 1.36e-87 261.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,4728X@75682|Oxalobacteraceae 28216|Betaproteobacteria O cytochrome C oxidase ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_246979_1 1223521.BBJX01000007_gene1516 1.83e-60 195.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2VHH3@28216|Betaproteobacteria,4AAVW@80864|Comamonadaceae 28216|Betaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_604148_1 614083.AWQR01000037_gene3475 6.25e-20 86.7 COG1879@1|root,COG1879@2|Bacteria,1MU95@1224|Proteobacteria,2VP5W@28216|Betaproteobacteria,4ADE6@80864|Comamonadaceae 28216|Betaproteobacteria G PFAM periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_604148_2 614083.AWQR01000037_gene3476 7.78e-72 224.0 COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2VMT3@28216|Betaproteobacteria,4ACR3@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_427939_1 688245.CtCNB1_4600 1.01e-84 262.0 COG3203@1|root,COG3203@2|Bacteria,1R5T2@1224|Proteobacteria,2VMH6@28216|Betaproteobacteria,4ACZH@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM porin Gram-negative type - - - - - - - - - - - - Porin_4 k59_427953_1 349741.Amuc_0315 7.49e-39 147.0 COG1154@1|root,COG1154@2|Bacteria,46SAU@74201|Verrucomicrobia,2ITIS@203494|Verrucomicrobiae 203494|Verrucomicrobiae HI Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_783864_1 1538295.JY96_14055 1.33e-94 289.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VNAS@28216|Betaproteobacteria 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_247116_1 990073.ATHU01000001_gene697 2.11e-30 115.0 COG0675@1|root,COG1943@1|root,COG0675@2|Bacteria,COG1943@2|Bacteria,1MUU0@1224|Proteobacteria,42QJG@68525|delta/epsilon subdivisions,2YN5Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Putative transposase DNA-binding domain - - - ko:K07496 - - - - ko00000 - - - OrfB_IS605,OrfB_Zn_ribbon k59_783883_1 1005048.CFU_0746 2.21e-26 106.0 COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,2VIQ3@28216|Betaproteobacteria,4737U@75682|Oxalobacteraceae 28216|Betaproteobacteria M Mandelate racemase muconate lactonizing enzyme gudD - 4.2.1.40 ko:K01706 ko00053,ko01100,map00053,map01100 - R02752,R08056 RC00543 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_783883_2 1206777.B195_15817 1.05e-47 165.0 COG2223@1|root,COG2223@2|Bacteria,1NS91@1224|Proteobacteria,1T33J@1236|Gammaproteobacteria,1Z67J@136849|Pseudomonas syringae group 1236|Gammaproteobacteria P Major facilitator - - - - - - - - - - - - MFS_1 k59_84105_1 748280.NH8B_2524 9.82e-62 197.0 COG1309@1|root,COG1309@2|Bacteria,1MZEP@1224|Proteobacteria,2VRMH@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N k59_1047750_1 700598.Niako_6083 4.58e-104 306.0 COG1137@1|root,COG1137@2|Bacteria,4NDUG@976|Bacteroidetes,1IQQ1@117747|Sphingobacteriia 976|Bacteroidetes S ABC transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_84114_1 1005395.CSV86_11980 5.13e-28 107.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,1YVZG@136845|Pseudomonas putida group 1236|Gammaproteobacteria O Glutathione S-transferase yghU - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N k59_84114_2 614083.AWQR01000030_gene2839 3.1e-41 137.0 28YU9@1|root,2ZKMG@2|Bacteria,1P59G@1224|Proteobacteria,2W5KQ@28216|Betaproteobacteria,4AIWG@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_198723_1 1049564.TevJSym_al00690 4.53e-11 68.2 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1J7D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_156952_1 375286.mma_2490 4.62e-23 95.5 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2VHCA@28216|Betaproteobacteria,472PZ@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_156952_2 1005048.CFU_0035 1.16e-14 73.2 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,472KU@75682|Oxalobacteraceae 28216|Betaproteobacteria M Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_13940_1 1410666.JHXG01000007_gene2258 9.74e-13 71.6 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,2FMX2@200643|Bacteroidia 976|Bacteroidetes D CobQ CobB MinD ParA nucleotide binding domain soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_406276_1 614083.AWQR01000031_gene2659 2.33e-40 134.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,4AE2M@80864|Comamonadaceae 28216|Betaproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_406276_2 338969.Rfer_2194 1.11e-34 120.0 COG2965@1|root,COG2965@2|Bacteria,1N98W@1224|Proteobacteria,2VVZ4@28216|Betaproteobacteria,4AEVS@80864|Comamonadaceae 28216|Betaproteobacteria L Binds single-stranded DNA at the primosome assembly site (PAS) priB - - ko:K02686 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SSB k59_761428_3 869213.JCM21142_114591 1.6e-26 103.0 2DT8X@1|root,32UUQ@2|Bacteria,4NSYW@976|Bacteroidetes,47SF7@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_13943_1 1198452.Jab_2c23110 2.53e-82 247.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,47237@75682|Oxalobacteraceae 28216|Betaproteobacteria K PFAM Response regulator receiver domain, Transcriptional regulatory protein, C terminal qseB - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_13943_2 1198452.Jab_2c23100 6.4e-14 70.9 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,4730K@75682|Oxalobacteraceae 28216|Betaproteobacteria T Two-component sensor kinase N-terminal qseC - 2.7.13.3 ko:K02484,ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_906836_2 1048983.EL17_15300 1.08e-17 81.6 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,4NE2Y@976|Bacteroidetes,47KD4@768503|Cytophagia 976|Bacteroidetes P COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - - - - - - - - - - Lactamase_B,Rhodanese k59_343587_1 1000565.METUNv1_02834 1.49e-98 292.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VQ7D@28216|Betaproteobacteria 28216|Betaproteobacteria E transglutaminase domain protein - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_522389_1 1114970.PSF113_4712 1.37e-97 316.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1YMC9@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_120693_1 1120977.JHUX01000003_gene1830 2.84e-38 133.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,3NJ47@468|Moraxellaceae 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2288,iAF1260.b2288,iAPECO1_1312.APECO1_4277,iB21_1397.B21_02173,iBWG_1329.BWG_2062,iE2348C_1286.E2348C_2428,iEC042_1314.EC042_2529,iEC55989_1330.EC55989_2532,iECABU_c1320.ECABU_c26200,iECBD_1354.ECBD_1373,iECB_1328.ECB_02213,iECDH10B_1368.ECDH10B_2450,iECDH1ME8569_1439.ECDH1ME8569_2225,iECD_1391.ECD_02213,iECED1_1282.ECED1_2752,iECH74115_1262.ECH74115_3427,iECIAI1_1343.ECIAI1_2362,iECIAI39_1322.ECIAI39_2435,iECO103_1326.ECO103_2752,iECO26_1355.ECO26_3276,iECOK1_1307.ECOK1_2521,iECP_1309.ECP_2327,iECS88_1305.ECS88_2435,iECSE_1348.ECSE_2545,iECSP_1301.ECSP_3162,iECUMN_1333.ECUMN_2627,iECW_1372.ECW_m2476,iECs_1301.ECs3172,iEKO11_1354.EKO11_1479,iETEC_1333.ETEC_2423,iEcDH1_1363.EcDH1_1369,iEcE24377_1341.EcE24377A_2581,iEcHS_1320.EcHS_A2437,iEcSMS35_1347.EcSMS35_2442,iEcolC_1368.EcolC_1364,iG2583_1286.G2583_2825,iJN746.PP_4119,iJO1366.b2288,iJR904.b2288,iLF82_1304.LF82_1539,iNRG857_1313.NRG857_11585,iSBO_1134.SBO_2321,iSDY_1059.SDY_2484,iSFV_1184.SFV_2355,iSF_1195.SF2364,iSFxv_1172.SFxv_2608,iSSON_1240.SSON_2345,iS_1188.S2499,iSbBS512_1146.SbBS512_E2664,iUMN146_1321.UM146_05375,iUTI89_1310.UTI89_C2568,iWFL_1372.ECW_m2476,iY75_1357.Y75_RS11995,ic_1306.c2829 Oxidored_q4 k59_870535_1 1000565.METUNv1_00762 9.92e-101 303.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_372955_1 258052.JNYV01000005_gene2402 1.44e-12 66.2 COG1024@1|root,COG1024@2|Bacteria,2GJ63@201174|Actinobacteria 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_372955_2 179408.Osc7112_4373 2.5e-58 209.0 COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales 1117|Cyanobacteria M Tetratricopeptide repeat - - - - - - - - - - - - DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_522410_1 614083.AWQR01000032_gene2910 6.08e-67 205.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,4AEBS@80864|Comamonadaceae 28216|Betaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_522410_2 535289.Dtpsy_3251 0.000916 41.2 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,4AB50@80864|Comamonadaceae 28216|Betaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_85344_1 1000565.METUNv1_03886 1.11e-106 314.0 COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2VNAR@28216|Betaproteobacteria,2KWAT@206389|Rhodocyclales 206389|Rhodocyclales ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - - - - - - - - - - SBP_bac_3 k59_85344_2 1000565.METUNv1_03885 3.64e-15 75.1 COG0265@1|root,COG0265@2|Bacteria,1RG0B@1224|Proteobacteria,2WFG8@28216|Betaproteobacteria 28216|Betaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_800856_1 296591.Bpro_0600 8.9e-127 372.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,4A9NB@80864|Comamonadaceae 28216|Betaproteobacteria E Amino acid amide ABC transporter substrate-binding protein, HAAT family - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_120727_1 714943.Mucpa_0679 2.31e-49 168.0 COG4585@1|root,COG4585@2|Bacteria,4NN4R@976|Bacteroidetes,1IY0X@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_225000_1 194699.Q775C6_BPBPP 9.59e-45 154.0 4QCAF@10239|Viruses,4QXVN@35237|dsDNA viruses no RNA stage,4QTUF@28883|Caudovirales,4QNGW@10744|Podoviridae 10744|Podoviridae S peptidase activity - - - - - - - - - - - - - k59_690767_2 1005048.CFU_3330 1.31e-47 162.0 COG0681@1|root,COG0681@2|Bacteria,1R7Z4@1224|Proteobacteria,2VPZJ@28216|Betaproteobacteria,474PT@75682|Oxalobacteraceae 28216|Betaproteobacteria U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1118826_1 1458275.AZ34_12605 2.82e-75 232.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,4AAB7@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, GntR family frlR - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_301919_1 1286631.X805_11100 4.07e-46 154.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,1KJ4A@119065|unclassified Burkholderiales 28216|Betaproteobacteria E urea ABC transporter, ATP-binding protein urtE - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_301919_2 535289.Dtpsy_1029 5.52e-117 339.0 COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria,4ABG2@80864|Comamonadaceae 28216|Betaproteobacteria S HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_939865_1 864702.OsccyDRAFT_3099 7.69e-185 526.0 COG0114@1|root,COG0114@2|Bacteria,1G0AD@1117|Cyanobacteria,1HI05@1150|Oscillatoriales 1117|Cyanobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_50370_1 1000565.METUNv1_02537 3.5e-235 655.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,2KUC2@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_835765_1 1005048.CFU_3530 1.51e-63 214.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,475CY@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acetyl-coenzyme A synthetase N-terminus prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_406346_1 1158762.KB898049_gene748 2.68e-13 70.1 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - 7TM_transglut,NTP_transf_5,Transglut_core,Transglut_core3 k59_406346_2 596153.Alide_0772 1.81e-13 71.2 COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,2VQ55@28216|Betaproteobacteria,4AD26@80864|Comamonadaceae 28216|Betaproteobacteria O Trypsin - - - - - - - - - - - - Trypsin_2 k59_690794_2 573370.DMR_13460 9.36e-34 134.0 COG0438@1|root,COG0438@2|Bacteria,1NJ19@1224|Proteobacteria,42NG7@68525|delta/epsilon subdivisions,2WJJ7@28221|Deltaproteobacteria,2M8VC@213115|Desulfovibrionales 28221|Deltaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_3,Glycos_transf_1 k59_1013999_1 1000565.METUNv1_00154 6.3e-147 421.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,2KVXV@206389|Rhodocyclales 206389|Rhodocyclales S Short C-terminal domain - - - - - - - - - - - - Band_7_1,SHOCT k59_406358_1 882378.RBRH_00199 1.03e-50 171.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2VIEK@28216|Betaproteobacteria,1KGGD@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K21757 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_201058_1 398578.Daci_3457 5.32e-55 181.0 COG0175@1|root,COG0175@2|Bacteria,1NRYU@1224|Proteobacteria,2W1SH@28216|Betaproteobacteria,4AGQ2@80864|Comamonadaceae 28216|Betaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_835787_1 1000565.METUNv1_03671 1.34e-94 318.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_120788_1 640081.Dsui_2769 8.01e-83 275.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VMEI@28216|Betaproteobacteria,2KX67@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,Thiol-ester_cl k59_451579_1 614083.AWQR01000046_gene3345 5.64e-88 278.0 COG3914@1|root,COG4976@1|root,COG3914@2|Bacteria,COG4976@2|Bacteria,1QU3U@1224|Proteobacteria,2WH8E@28216|Betaproteobacteria,4AK47@80864|Comamonadaceae 28216|Betaproteobacteria O Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_16,TPR_8 k59_665954_1 640081.Dsui_1713 1.6e-35 131.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,2KUJP@206389|Rhodocyclales 206389|Rhodocyclales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_665954_2 640081.Dsui_1711 1.27e-47 161.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,2KVRQ@206389|Rhodocyclales 206389|Rhodocyclales H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_343753_1 1177179.A11A3_00710 1.59e-68 220.0 COG2357@1|root,COG2357@2|Bacteria,1RBSQ@1224|Proteobacteria,1RR52@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Region found in RelA / SpoT proteins - - - - - - - - - - - - RelA_SpoT k59_522558_2 1336208.JADY01000001_gene850 6.41e-07 53.5 COG0500@1|root,COG2226@2|Bacteria,1RFBE@1224|Proteobacteria,2TX7N@28211|Alphaproteobacteria,2JWCC@204441|Rhodospirillales 204441|Rhodospirillales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_201091_1 1504672.669786651 3.07e-74 225.0 COG5631@1|root,COG5631@2|Bacteria,1RDM3@1224|Proteobacteria,2VM9E@28216|Betaproteobacteria,4AANQ@80864|Comamonadaceae 28216|Betaproteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_27 k59_201091_2 598467.BrE312_0038 5.66e-10 61.2 COG1794@1|root,COG1794@2|Bacteria,1MW3C@1224|Proteobacteria,1RZBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M racemase activity, acting on amino acids and derivatives - - - - - - - - - - - - - k59_14063_1 862908.BMS_1937 7.77e-22 94.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2MT45@213481|Bdellovibrionales,2WJQR@28221|Deltaproteobacteria 213481|Bdellovibrionales F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_800950_1 795666.MW7_1078 5.45e-99 292.0 28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,2VNFP@28216|Betaproteobacteria,1KBGS@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_302001_1 1236976.JCM16418_3735 5.67e-07 56.2 COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,26RUX@186822|Paenibacillaceae 91061|Bacilli P Arsenical pump membrane protein - - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - CitMHS k59_976213_1 1121035.AUCH01000002_gene1553 1.23e-44 156.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VN6W@28216|Betaproteobacteria,2KVGJ@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_transf_4,Glycos_transf_1 k59_976213_2 640081.Dsui_1838 6.53e-33 121.0 COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VK7S@28216|Betaproteobacteria,2KUTS@206389|Rhodocyclales 206389|Rhodocyclales H Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_265217_1 1215114.BBIU01000041_gene3997 2.69e-24 98.6 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 moeB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - iECIAI1_1343.ECIAI1_0865,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884 ThiF k59_265217_2 1120977.JHUX01000003_gene1456 9.56e-34 129.0 COG0661@1|root,COG0661@2|Bacteria,1N1UJ@1224|Proteobacteria,1RP1G@1236|Gammaproteobacteria,3NJ0D@468|Moraxellaceae 1236|Gammaproteobacteria S ABC1 family aarF - - - - - - - - - - - ABC1,APH k59_1014044_2 1129146.H2BDG1_9CAUD 5.85e-34 131.0 4QBF0@10239|Viruses,4QVD8@35237|dsDNA viruses no RNA stage,4QRRZ@28883|Caudovirales,4QMKU@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_157143_1 1122604.JONR01000009_gene2336 3.6e-46 164.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,1X3RJ@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_616851_1 1500894.JQNN01000001_gene3195 7.55e-106 325.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,473J9@75682|Oxalobacteraceae 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_835829_1 760192.Halhy_5656 3.02e-21 98.6 COG2373@1|root,COG3291@1|root,COG4386@1|root,COG4409@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,COG4386@2|Bacteria,COG4409@2|Bacteria,4NDZC@976|Bacteroidetes,1IR0W@117747|Sphingobacteriia 976|Bacteroidetes G Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - CHU_C,PKD,SASA,SprB k59_582657_1 207954.MED92_03423 2.01e-30 110.0 2DZDS@1|root,32V82@2|Bacteria,1N6EX@1224|Proteobacteria,1S9VE@1236|Gammaproteobacteria,1XKPN@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_548803_1 292.DM42_1782 7.49e-05 44.7 COG0515@1|root,COG0515@2|Bacteria,1QTW9@1224|Proteobacteria,2VMFA@28216|Betaproteobacteria 28216|Betaproteobacteria KLT serine threonine protein kinase - - - - - - - - - - - - - k59_157152_1 85643.Tmz1t_2831 9.8e-50 187.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,2KZWQ@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - CBS,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_14096_1 1137799.GZ78_01240 3.35e-143 427.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1XIDU@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA fadH - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_666037_1 257310.BB3533 2.31e-92 276.0 2CAZB@1|root,2Z9VC@2|Bacteria,1R89D@1224|Proteobacteria,2VQZ3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - AAA_24 k59_225105_1 1123487.KB892837_gene3977 3.34e-87 287.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,MASE3,PAS,PAS_4,PAS_9,Phosphonate-bd k59_201182_1 925409.KI911562_gene2313 4.86e-35 134.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,1IP7W@117747|Sphingobacteriia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_120871_1 1218084.BBJK01000075_gene5218 4.68e-15 74.7 COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,1K855@119060|Burkholderiaceae 28216|Betaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_848796_1 426114.THI_2031 8.32e-10 59.3 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,1KKEE@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_848796_2 365046.Rta_30270 5.57e-64 207.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,4AAXF@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_61710_1 1000565.METUNv1_00227 1.13e-45 151.0 2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,2VYVD@28216|Betaproteobacteria 28216|Betaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_61710_2 1000565.METUNv1_00228 5.46e-25 101.0 28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2VMSI@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_883155_1 700598.Niako_6960 2.17e-48 166.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,4NEJ3@976|Bacteroidetes,1IQB1@117747|Sphingobacteriia 976|Bacteroidetes IM Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ - 3.5.1.108,4.2.1.59 ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC k59_132785_1 1198452.Jab_2c32260 1.63e-49 172.0 COG0644@1|root,COG0644@2|Bacteria,1R41S@1224|Proteobacteria 1224|Proteobacteria C Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_562476_1 1122951.ATUE01000005_gene1612 1.55e-87 281.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,3NJYW@468|Moraxellaceae 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_702409_2 748280.NH8B_0016 9.39e-98 292.0 COG1073@1|root,COG1073@2|Bacteria,1N03B@1224|Proteobacteria,2VV1P@28216|Betaproteobacteria 28216|Betaproteobacteria S alpha beta - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_388150_1 279714.FuraDRAFT_3828 3.32e-19 84.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,2KQ1P@206351|Neisseriales 206351|Neisseriales L Psort location Cytoplasmic, score 9.97 exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_388150_2 1122951.ATUE01000005_gene1984 8.36e-50 164.0 COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,3NJ33@468|Moraxellaceae 1236|Gammaproteobacteria J 16S RNA G1207 methylase RsmC - - - - - - - - - - - - MTS k59_771348_1 633149.Bresu_2878 5.97e-30 124.0 COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2KFX0@204458|Caulobacterales 204458|Caulobacterales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_1129825_1 1000565.METUNv1_01557 2.03e-95 306.0 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2VNYP@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 k59_234863_1 1276756.AUEX01000015_gene1997 4.91e-157 458.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,4AA5M@80864|Comamonadaceae 28216|Betaproteobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_949648_1 929556.Solca_3148 1.32e-80 250.0 COG2070@1|root,COG2070@2|Bacteria,4NFIW@976|Bacteroidetes,1J0C0@117747|Sphingobacteriia 976|Bacteroidetes S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_277533_1 1408428.JNJP01000064_gene613 8.8e-78 246.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2M7SQ@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family capL - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_949666_1 414684.RC1_0879 6.35e-129 374.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria,2JQ0S@204441|Rhodospirillales 204441|Rhodospirillales N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_61798_1 290398.Csal_1340 1.73e-92 303.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1XI6H@135619|Oceanospirillales 135619|Oceanospirillales E Dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_25539_1 448385.sce5068 6.41e-33 130.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MX4K@1224|Proteobacteria,42WVW@68525|delta/epsilon subdivisions,2X77J@28221|Deltaproteobacteria,2YUN6@29|Myxococcales 28221|Deltaproteobacteria P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_625693_1 1156919.QWC_18827 1.45e-26 112.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,3T1KE@506|Alcaligenaceae 28216|Betaproteobacteria C cytochrome c oxidase ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_562557_1 257310.BB3160 2.52e-49 158.0 COG4680@1|root,COG4680@2|Bacteria,1N036@1224|Proteobacteria,2VSXP@28216|Betaproteobacteria 28216|Betaproteobacteria S HigB_toxin, RelE-like toxic component of a toxin-antitoxin system - - - ko:K19166 - - - - ko00000,ko01000,ko02048 - - - HigB_toxin k59_388271_1 1348114.OM33_17400 6.48e-12 67.0 COG4805@1|root,COG4805@2|Bacteria,1MZDR@1224|Proteobacteria,1RZK8@1236|Gammaproteobacteria,2Q0SD@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_1026552_1 1123257.AUFV01000009_gene2161 2.65e-178 512.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria,1X515@135614|Xanthomonadales 135614|Xanthomonadales V Type I restriction-modification system methyltransferase subunit - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_1129887_1 1122135.KB893146_gene1736 5.25e-12 71.6 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria 28211|Alphaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_987909_1 1000565.METUNv1_00941 2.54e-91 276.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VHZF@28216|Betaproteobacteria,2KVV1@206389|Rhodocyclales 206389|Rhodocyclales E Bacterial transferase hexapeptide (six repeats) - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_234923_1 1429916.X566_13795 2.23e-12 67.4 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,3JU1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Alanine dehydrogenase/PNT, C-terminal domain pntAA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1097811_1 398578.Daci_1939 0.000489 43.9 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - HNH,HNH_5,NinG k59_848969_1 1123367.C666_11875 4.59e-24 107.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KXVB@206389|Rhodocyclales 206389|Rhodocyclales T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,dCache_1 k59_987930_1 449447.MAE_57400 6.94e-58 193.0 COG0090@1|root,COG0090@2|Bacteria,1G1P7@1117|Cyanobacteria 1117|Cyanobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rpl2 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_848992_1 159087.Daro_1002 6.79e-69 217.0 COG0834@1|root,COG0834@2|Bacteria,1RIGN@1224|Proteobacteria,2VMMR@28216|Betaproteobacteria,2KWHJ@206389|Rhodocyclales 206389|Rhodocyclales ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_625744_1 614083.AWQR01000018_gene1742 7.29e-09 55.5 COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,4AAZP@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_625744_2 614083.AWQR01000018_gene1741 1.48e-80 248.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJAM@28216|Betaproteobacteria,4AANH@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_61864_1 29581.BW37_01538 0.000252 43.1 COG5006@1|root,COG5006@2|Bacteria,1MXR7@1224|Proteobacteria,2VM1R@28216|Betaproteobacteria,476T8@75682|Oxalobacteraceae 28216|Betaproteobacteria S EamA-like transporter family rhtA - - ko:K11939 - - - - ko00000,ko02000 2.A.7.3.6 - - EamA k59_61864_2 1007105.PT7_2038 1.35e-95 296.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,3T2R1@506|Alcaligenaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family ilvG5 - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_492560_1 1000565.METUNv1_00361 8.66e-126 366.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 206389|Rhodocyclales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_416797_1 335659.S23_20880 6.11e-77 247.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3JRZ3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G PQQ-like domain exaA - 1.1.2.8,1.1.5.11 ko:K00114,ko:K20937 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_702560_1 202952.BBLI01000036_gene2450 1.56e-30 124.0 2EXMM@1|root,33QXG@2|Bacteria,1NRHQ@1224|Proteobacteria,1SM8D@1236|Gammaproteobacteria,3NIQE@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_562629_1 760117.JN27_16120 1.82e-117 347.0 COG0683@1|root,COG0683@2|Bacteria,1N1MX@1224|Proteobacteria,2VJMT@28216|Betaproteobacteria 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_562633_1 1219031.BBJR01000064_gene1261 1.99e-97 294.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,4AAYK@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_883458_1 700598.Niako_5644 2.24e-84 277.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1IPC5@117747|Sphingobacteriia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_771499_1 1121373.KB903621_gene1818 1.35e-20 91.3 COG3386@1|root,COG3386@2|Bacteria,4NJKD@976|Bacteroidetes,47PXA@768503|Cytophagia 976|Bacteroidetes G amine dehydrogenase activity - - - - - - - - - - - - SGL k59_849034_3 398578.Daci_5366 7.33e-29 103.0 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,4AFGJ@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_492606_1 395494.Galf_2006 1.85e-36 140.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria 28216|Betaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - - k59_592767_1 159087.Daro_3377 2.23e-69 209.0 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,2KWKQ@206389|Rhodocyclales 206389|Rhodocyclales F phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_592767_2 159087.Daro_3376 1.25e-72 218.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales 206389|Rhodocyclales FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_492613_1 1268622.AVS7_03975 5.64e-78 234.0 COG2236@1|root,COG2236@2|Bacteria,1R675@1224|Proteobacteria,2VPZG@28216|Betaproteobacteria,4AA1G@80864|Comamonadaceae 28216|Betaproteobacteria F PFAM Phosphoribosyltransferase gpt - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_492613_2 887062.HGR_09610 6.25e-13 67.4 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,4AAS1@80864|Comamonadaceae 28216|Betaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_771510_1 1000565.METUNv1_00734 4.06e-85 256.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,2KWVX@206389|Rhodocyclales 206389|Rhodocyclales M Transglycosylase SLT domain slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - DUF4124,SLT k59_883527_1 402626.Rpic_0622 4.54e-97 291.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1JZN1@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_564794_1 4792.ETI37477 4.84e-39 153.0 29FCZ@1|root,2RNII@2759|Eukaryota,3QI7X@4776|Peronosporales 4776|Peronosporales - - - - - - - - - - - - - - - k59_391755_1 1235457.C404_21870 2.31e-116 349.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VHP4@28216|Betaproteobacteria,1K1E8@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1132208_1 1000565.METUNv1_00774 1.48e-58 193.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,2KU6Y@206389|Rhodocyclales 206389|Rhodocyclales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_564846_1 296591.Bpro_0966 7.47e-72 229.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2VJD3@28216|Betaproteobacteria,4AC9E@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_171458_1 398578.Daci_1943 2.72e-49 176.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria 1224|Proteobacteria M Membrane - - - - - - - - - - - - - k59_27774_1 445961.IW15_10445 1.63e-57 189.0 COG0500@1|root,COG0500@2|Bacteria,4NFKM@976|Bacteroidetes,1IJCK@117743|Flavobacteriia,3ZUN4@59732|Chryseobacterium 976|Bacteroidetes Q Methyltransferase - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,Methyltransf_31,TehB k59_773350_1 1000565.METUNv1_00212 1.04e-122 362.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUM4@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_418931_2 326424.FRAAL1745 2.01e-05 49.3 COG1403@1|root,COG2310@1|root,COG1403@2|Bacteria,COG2310@2|Bacteria,2GK6H@201174|Actinobacteria,4EW0X@85013|Frankiales 201174|Actinobacteria TV Stress protein - - - ko:K05792 - - - - ko00000 - - - DUF2510,HNH,TerD k59_887271_1 1538644.KO02_05670 1.89e-20 89.7 COG0248@1|root,COG0248@2|Bacteria,4NEI0@976|Bacteroidetes,1IQKP@117747|Sphingobacteriia 976|Bacteroidetes FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_236880_1 614083.AWQR01000015_gene2517 2.71e-33 117.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,4AJGZ@80864|Comamonadaceae 28216|Betaproteobacteria L bacterial (prokaryotic) histone like domain - - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1132276_2 497964.CfE428DRAFT_0815 6.68e-53 177.0 COG1482@1|root,COG1482@2|Bacteria,46VQS@74201|Verrucomicrobia 74201|Verrucomicrobia G cell wall glycoprotein biosynthetic process - - - - - - - - - - - - - k59_171527_1 946483.Cenrod_0403 4.64e-06 47.8 COG1192@1|root,COG1192@2|Bacteria,1REZB@1224|Proteobacteria,2VR89@28216|Betaproteobacteria,4AE9I@80864|Comamonadaceae 28216|Betaproteobacteria D Involved in chromosome partitioning - - - - - - - - - - - - - k59_171527_2 614083.AWQR01000048_gene3216 7.57e-69 219.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,4A9YH@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_990154_1 1234364.AMSF01000018_gene1411 2.24e-41 147.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1099332_1 344747.PM8797T_17222 1.92e-54 192.0 COG2010@1|root,COG2010@2|Bacteria,2IY86@203682|Planctomycetes 203682|Planctomycetes C Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3,PSCyt1,PSCyt2,PSD1 k59_851804_1 926562.Oweho_1333 4.44e-48 157.0 COG1803@1|root,COG1803@2|Bacteria,4NQJ9@976|Bacteroidetes,1I3E4@117743|Flavobacteriia,2PBUK@246874|Cryomorphaceae 976|Bacteroidetes G MGS-like domain mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS k59_754694_1 1000565.METUNv1_02720 2.13e-115 336.0 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,2KW20@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_1111490_4 375286.mma_2198 1.3e-72 239.0 28QU5@1|root,2ZD9H@2|Bacteria,1RAU8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_899462_1 1177154.Y5S_00002 1.52e-74 238.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1XR5H@135619|Oceanospirillales 135619|Oceanospirillales KLT COG0515 Serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_683261_1 365044.Pnap_1957 1.98e-12 67.4 COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,4AGRG@80864|Comamonadaceae 28216|Betaproteobacteria IJ Formyl transferase hoxX - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N k59_683261_2 1000565.METUNv1_03210 1.57e-224 622.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,2KVH9@206389|Rhodocyclales 206389|Rhodocyclales O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_112676_1 870187.Thini_3860 3.37e-25 104.0 COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,1S0WH@1236|Gammaproteobacteria,46244@72273|Thiotrichales 72273|Thiotrichales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_112676_2 1439940.BAY1663_02802 9.29e-78 236.0 COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,1RMNT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Low-potential electron donor to a number of redox enzymes nifF - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_438050_2 1198452.Jab_1c10960 8.32e-51 168.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VNMX@28216|Betaproteobacteria,4753K@75682|Oxalobacteraceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 pldB - 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_652364_1 365046.Rta_30920 4.49e-79 258.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria,4AD9X@80864|Comamonadaceae 28216|Betaproteobacteria L DEAD H associated domain protein lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_187927_1 1000565.METUNv1_02551 2.54e-164 465.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,2KUD4@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_861857_1 240016.ABIZ01000001_gene4654 7.05e-93 283.0 COG0162@1|root,COG0162@2|Bacteria,46UVG@74201|Verrucomicrobia,2ITSI@203494|Verrucomicrobiae 203494|Verrucomicrobiae J tRNA synthetases class I (W and Y) - - - - - - - - - - - - S4,tRNA-synt_1b k59_292899_2 392499.Swit_4798 1.13e-48 161.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2K1RM@204457|Sphingomonadales 204457|Sphingomonadales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_187933_1 1000565.METUNv1_02923 8.69e-91 275.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,2KUAI@206389|Rhodocyclales 206389|Rhodocyclales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_187933_2 1415778.JQMM01000001_gene2146 3.51e-36 127.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1J5X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_933092_1 748247.AZKH_3654 3.12e-165 473.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,2KV7A@206389|Rhodocyclales 206389|Rhodocyclales P Chromate Ion Transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_933092_2 1217714.F975_02784 1.69e-06 48.5 COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,1SDG5@1236|Gammaproteobacteria,3NQ1R@468|Moraxellaceae 1236|Gammaproteobacteria S Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 k59_1080743_1 1000565.METUNv1_02921 2.45e-60 195.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,2KWAY@206389|Rhodocyclales 206389|Rhodocyclales S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_330684_1 323261.Noc_A0020 1.14e-29 116.0 2BSN5@1|root,32MQR@2|Bacteria,1MYG6@1224|Proteobacteria,1SQZ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Plasmid replication region DNA-binding N-term - - - - - - - - - - - - KfrA_N k59_330684_2 399795.CtesDRAFT_PD2413 5.57e-15 73.9 COG3091@1|root,COG3091@2|Bacteria,1RBMK@1224|Proteobacteria,2VH6Q@28216|Betaproteobacteria,4AA71@80864|Comamonadaceae 28216|Betaproteobacteria S SprT-like family - - - - - - - - - - - - SprT-like k59_968917_1 1408164.MOLA814_00997 8.89e-85 257.0 COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2VPPT@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the iron ascorbate-dependent oxidoreductase family - - - - - - - - - - - - 2OG-FeII_Oxy,DIOX_N k59_968920_1 614083.AWQR01000005_gene998 4.37e-73 248.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,4ACFQ@80864|Comamonadaceae 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_187962_1 267608.RSc0098 2.94e-106 321.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2VKXB@28216|Betaproteobacteria,1K54B@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the alkaline phosphatase family phoA2 - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_399867_1 383372.Rcas_3391 3.56e-69 223.0 COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi,374WU@32061|Chloroflexia 32061|Chloroflexia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_112704_1 135651.CBN04599 4.43e-08 54.7 COG0823@1|root,2RZSE@2759|Eukaryota,3A21S@33154|Opisthokonta,3BR9D@33208|Metazoa,3D80R@33213|Bilateria,40DCD@6231|Nematoda,1KY75@119089|Chromadorea,40Y0Z@6236|Rhabditida 33208|Metazoa U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_292939_2 1000565.METUNv1_01200 1.37e-71 224.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,2VQY3@28216|Betaproteobacteria,2KXFS@206389|Rhodocyclales 206389|Rhodocyclales NU Prokaryotic N-terminal methylation motif - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_719987_1 582744.Msip34_0635 1.9e-43 165.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KMAI@206350|Nitrosomonadales 206350|Nitrosomonadales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_399870_1 614083.AWQR01000020_gene204 9.82e-127 375.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,4A9ZQ@80864|Comamonadaceae 28216|Betaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_933115_2 795666.MW7_1049 3.2e-21 91.3 COG5449@1|root,COG5449@2|Bacteria,1MXK2@1224|Proteobacteria,2VSPS@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_540768_1 477184.KYC_17507 9.97e-18 79.0 2FBPB@1|root,343UB@2|Bacteria,1P394@1224|Proteobacteria,2W41R@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_540768_2 1150398.JIBJ01000004_gene2648 5.2e-44 170.0 COG4225@1|root,COG4225@2|Bacteria 2|Bacteria S unsaturated chondroitin disaccharide hydrolase activity - - - - - - - - - - - - BNR_4 k59_576169_2 195250.CM001776_gene2577 1.65e-93 296.0 COG0318@1|root,COG0318@2|Bacteria,1GQE8@1117|Cyanobacteria,1H02N@1129|Synechococcus 1117|Cyanobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897,ko:K18660 ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280,R03383 RC00004,RC00014,RC00137 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_933123_1 1121441.AUCX01000009_gene2546 2.79e-33 133.0 COG3899@1|root,COG5002@1|root,COG3899@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - AAA_16,GAF,HAMP,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg,dCache_1 k59_1006301_1 1000565.METUNv1_04018 1.2e-90 279.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,2KZZK@206389|Rhodocyclales 206389|Rhodocyclales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_652474_1 1000565.METUNv1_03446 2.28e-57 197.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KWW5@206389|Rhodocyclales 206389|Rhodocyclales M AsmA family - - - - - - - - - - - - AsmA k59_652474_2 1000565.METUNv1_03447 1.54e-74 225.0 COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2VRBU@28216|Betaproteobacteria,2KWTY@206389|Rhodocyclales 206389|Rhodocyclales S protein, possibly involved in utilization of glycolate and propanediol - - - - - - - - - - - - Haem_degrading k59_399890_1 596154.Alide2_0107 1.41e-72 240.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC mgtA - 3.6.3.2 ko:K01531 - - - - ko00000,ko01000 3.A.3.4 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1111572_1 1101190.ARWB01000001_gene3611 9.32e-05 44.3 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,370EF@31993|Methylocystaceae 28211|Alphaproteobacteria G PQQ-like domain - - - - - - - - - - - - PQQ,PQQ_2,PQQ_3 k59_1111572_2 1219031.BBJR01000044_gene1395 7.33e-14 67.0 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,2VW0H@28216|Betaproteobacteria,4AFDE@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM SlyX family protein slyX - - ko:K03745 - - - - ko00000 - - - SlyX k59_1111572_3 1122201.AUAZ01000008_gene360 4.68e-12 65.1 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,46406@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_754774_1 1121035.AUCH01000004_gene400 8.07e-08 58.2 COG2208@1|root,COG4252@1|root,COG2208@2|Bacteria,COG4252@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,2KX5A@206389|Rhodocyclales 206389|Rhodocyclales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_78183_1 1121004.ATVC01000012_gene2135 2.86e-91 273.0 COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,2VRS9@28216|Betaproteobacteria 28216|Betaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_78183_2 1538295.JY96_20225 1.77e-46 159.0 COG4951@1|root,COG4951@2|Bacteria,1RE15@1224|Proteobacteria,2VSA8@28216|Betaproteobacteria,1KKWJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DNA primase small subunit - - - - - - - - - - - - - k59_827998_2 1120977.JHUX01000010_gene117 9.87e-26 102.0 COG1802@1|root,COG1802@2|Bacteria,1RIE7@1224|Proteobacteria,1S6K0@1236|Gammaproteobacteria,3NJQF@468|Moraxellaceae 1236|Gammaproteobacteria K FCD domain - - - - - - - - - - - - FCD,GntR k59_363878_1 1123248.KB893321_gene505 3.08e-40 150.0 COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,4NENE@976|Bacteroidetes,1IQIP@117747|Sphingobacteriia 976|Bacteroidetes P H( )-stimulated, divalent metal cation uptake system mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp,Usp k59_899564_1 1117108.PAALTS15_06754 9.2e-24 104.0 COG0155@1|root,COG0155@2|Bacteria,1TS58@1239|Firmicutes,4HBEX@91061|Bacilli,26R8S@186822|Paenibacillaceae 91061|Bacilli P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate nirA - 1.7.7.1 ko:K00366 ko00910,ko01120,map00910,map01120 M00531 R00790 RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_42538_1 468059.AUHA01000008_gene2734 4.75e-112 349.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,1IPYI@117747|Sphingobacteriia 976|Bacteroidetes O with chaperone activity ATP-binding subunit clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_1111581_1 1122951.ATUE01000005_gene1550 1.52e-58 189.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,3NIVB@468|Moraxellaceae 1236|Gammaproteobacteria P Transporter associated domain corC GO:0001897,GO:0001906,GO:0001907,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0009987,GO:0016020,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071944 - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1111581_2 95619.PM1_0205015 2.12e-28 106.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_330804_1 1000565.METUNv1_02260 0.0 1080.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KUP0@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1006346_1 1123508.JH636445_gene6824 6.65e-78 249.0 COG4805@1|root,COG4805@2|Bacteria,2IXQZ@203682|Planctomycetes 203682|Planctomycetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_968987_1 595536.ADVE02000003_gene4003 5.74e-43 159.0 COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_148170_1 929556.Solca_3635 5.65e-15 70.9 COG1247@1|root,COG1247@2|Bacteria,4NNGH@976|Bacteroidetes,1ISBX@117747|Sphingobacteriia 976|Bacteroidetes M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Acetyltransf_4 k59_148172_1 1000565.METUNv1_00132 1.48e-137 394.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,2KU6A@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_438223_1 886293.Sinac_7112 6.03e-105 317.0 COG4102@1|root,COG4102@2|Bacteria,2J4YY@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_540824_1 342113.DM82_3209 7.09e-52 179.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1JZMS@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.39 ko:K00146 ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 - R02536 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_330829_1 1000565.METUNv1_04026 8.47e-103 308.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KVIV@206389|Rhodocyclales 206389|Rhodocyclales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_968995_1 479433.Caci_2137 0.000104 44.7 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1042882_1 266264.Rmet_0262 6.32e-65 213.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,1K4BC@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1042882_2 883126.HMPREF9710_03238 4.19e-17 79.7 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4728E@75682|Oxalobacteraceae 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_654410_1 911045.PSE_3726 0.000192 43.5 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_654410_2 402881.Plav_2935 1.57e-24 100.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,1JNRB@119043|Rhodobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase Echdc - - - - - - - - - - - ECH_1 k59_1082777_1 1000565.METUNv1_00716 1.12e-54 176.0 COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,2VSG8@28216|Betaproteobacteria 28216|Betaproteobacteria S Psort location CytoplasmicMembrane, score - - - ko:K09793 - - - - ko00000 - - - DUF456 k59_1082777_2 1000565.METUNv1_00717 1.12e-203 570.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,2KVTN@206389|Rhodocyclales 206389|Rhodocyclales H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_79262_1 1453498.LG45_00380 6.41e-60 192.0 COG1376@1|root,COG1376@2|Bacteria,4NNX7@976|Bacteroidetes,1I2D3@117743|Flavobacteriia,2P0HM@237|Flavobacterium 976|Bacteroidetes S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD_2 k59_934097_1 1458275.AZ34_09205 4.76e-77 237.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,4ABE8@80864|Comamonadaceae 28216|Betaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_400741_1 1000565.METUNv1_01995 2.23e-92 276.0 COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,2VKMX@28216|Betaproteobacteria,2KX4M@206389|Rhodocyclales 206389|Rhodocyclales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_577112_1 1122951.ATUE01000006_gene1414 1.44e-88 270.0 COG0715@1|root,COG0715@2|Bacteria,1QVPH@1224|Proteobacteria,1T2FY@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - - - - - - - - - - - k59_863139_1 1000565.METUNv1_00842 4.36e-101 313.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,2KUVE@206389|Rhodocyclales 206389|Rhodocyclales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_755672_1 1000565.METUNv1_02924 0.000329 42.4 COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,2KWXG@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial SH3 domain - - - - - - - - - - - - SH3_4 k59_755672_2 1000565.METUNv1_02925 1.86e-92 272.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,2KW5X@206389|Rhodocyclales 206389|Rhodocyclales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_755672_3 1000565.METUNv1_02926 9.31e-47 150.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2VU2J@28216|Betaproteobacteria,2KWWG@206389|Rhodocyclales 206389|Rhodocyclales O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_755672_4 1000565.METUNv1_02927 3.35e-71 216.0 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,2KWVI@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_755672_5 1000565.METUNv1_02928 1.67e-183 511.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,2KVSQ@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_7118_1 700598.Niako_0476 2.31e-54 192.0 COG5412@1|root,COG5412@2|Bacteria,4NJXH@976|Bacteroidetes,1IX5R@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157,Endonuclea_NS_2 k59_934109_1 1122919.KB905589_gene4112 1.59e-10 63.9 COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,4HBME@91061|Bacilli,26SSJ@186822|Paenibacillaceae 91061|Bacilli G Quinoprotein glucose dehydrogenase gdhB - - - - - - - - - - - GSDH k59_128241_2 1144342.PMI40_04992 2.84e-15 75.9 COG3418@1|root,COG3418@2|Bacteria,1NGUP@1224|Proteobacteria,2VXS1@28216|Betaproteobacteria,474RS@75682|Oxalobacteraceae 28216|Betaproteobacteria N Flagellar biosynthesis type III secretory pathway chaperone flgN - - ko:K02399 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgN k59_93003_1 614083.AWQR01000007_gene386 1.26e-108 321.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,4AAXW@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_913413_1 381666.H16_A0687 5.53e-63 196.0 COG1522@1|root,COG1522@2|Bacteria,1MZ9D@1224|Proteobacteria,2VR5I@28216|Betaproteobacteria,1KH89@119060|Burkholderiaceae 28216|Betaproteobacteria K AsnC-type helix-turn-helix domain - - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_557360_1 1005048.CFU_3479 7.57e-73 237.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4733B@75682|Oxalobacteraceae 28216|Betaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_356067_1 452637.Oter_3039 2.72e-38 140.0 COG1696@1|root,COG1696@2|Bacteria,46TUI@74201|Verrucomicrobia 74201|Verrucomicrobia M PFAM membrane bound O-acyl transferase MBOAT family protein - - - - - - - - - - - - MBOAT k59_356067_2 290317.Cpha266_2598 2.77e-31 110.0 2E3AG@1|root,32Y9Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_463064_1 1198452.Jab_1c10620 3.15e-53 174.0 COG0406@1|root,COG0406@2|Bacteria,1N14H@1224|Proteobacteria,2VU12@28216|Betaproteobacteria,474KZ@75682|Oxalobacteraceae 28216|Betaproteobacteria G phosphoglycerate mutase cobC - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_622342_1 351348.Maqu_2491 8.68e-15 78.6 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,4646K@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_557372_1 421052.F945_02835 1.02e-133 384.0 COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,1RQQX@1236|Gammaproteobacteria,3NKIM@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family hcaA - 4.1.2.41,4.2.1.101 ko:K18383 ko00360,ko01100,ko01110,map00360,map01100,map01110 - R05772,R05773 RC00307,RC01468,RC01828 ko00000,ko00001,ko01000 - - iJN746.PP_3358 ECH_1 k59_311238_1 1504672.669786861 5.11e-72 238.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,4AAN3@80864|Comamonadaceae 28216|Betaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1125499_1 290397.Adeh_0976 1.25e-17 83.6 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,42KZ4@68525|delta/epsilon subdivisions,2WKT2@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP drug resistance transporter, Bcr CflA - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_983416_1 314285.KT71_14804 1.07e-20 91.3 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1J7P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Colicin V production protein cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_21539_1 204773.HEAR1159 1.44e-193 543.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria,47573@75682|Oxalobacteraceae 28216|Betaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_21539_2 742159.HMPREF0004_2170 6.08e-09 55.8 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,3T1W4@506|Alcaligenaceae 28216|Betaproteobacteria BQ Deacetylases including yeast histone deacetylase and acetoin utilization protein hdaH - - - - - - - - - - - Hist_deacetyl k59_211508_1 1100720.ALKN01000018_gene1731 5.42e-90 281.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2VKJR@28216|Betaproteobacteria,4ACE4@80864|Comamonadaceae 28216|Betaproteobacteria L DNA methylase yhdJ - - - - - - - - - - - N6_N4_Mtase,ParBc k59_57850_1 1123255.JHYS01000012_gene1318 1.09e-121 362.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,4AACX@80864|Comamonadaceae 28216|Betaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1061982_1 1198452.Jab_1c08170 3.73e-82 257.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria,475FB@75682|Oxalobacteraceae 28216|Betaproteobacteria S NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_356148_1 1137799.GZ78_13055 1.78e-05 52.4 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1XISG@135619|Oceanospirillales 135619|Oceanospirillales I Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.5 ko:K13777 ko00281,map00281 - R03494 RC00367,RC00942 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_698093_1 543728.Vapar_1724 2.54e-34 125.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKC6@28216|Betaproteobacteria,4AC8C@80864|Comamonadaceae 28216|Betaproteobacteria G TRAP dicarboxylate transporter - - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP k59_698093_2 595537.Varpa_1895 1.82e-48 163.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKC6@28216|Betaproteobacteria,4AC8C@80864|Comamonadaceae 28216|Betaproteobacteria G TRAP dicarboxylate transporter - - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP k59_983433_1 1137799.GZ78_28585 7.86e-21 95.1 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1XHB1@135619|Oceanospirillales 135619|Oceanospirillales T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9 k59_878609_1 305900.GV64_02445 7.94e-38 147.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XH82@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - ko:K20972 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE8,HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_1095110_1 1242864.D187_010399 3.95e-133 405.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,42S4X@68525|delta/epsilon subdivisions,2WNPW@28221|Deltaproteobacteria,2YU9Y@29|Myxococcales 28221|Deltaproteobacteria O Peptidase family M13 - - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k59_946061_1 1198452.Jab_2c30260 4.67e-108 328.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2W0UE@28216|Betaproteobacteria,474PS@75682|Oxalobacteraceae 28216|Betaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1125542_1 1349767.GJA_2575 2.28e-88 286.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,476GP@75682|Oxalobacteraceae 28216|Betaproteobacteria P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_946062_1 744872.Spica_0379 6.44e-75 249.0 COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes 203691|Spirochaetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_946062_2 545694.TREPR_0931 5.39e-07 50.1 COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes 203691|Spirochaetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_57870_1 1121285.AUFK01000011_gene416 6.53e-11 63.9 COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia,3ZNSA@59732|Chryseobacterium 976|Bacteroidetes CO Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Thioredoxin,Thioredoxin_9 k59_57870_2 929713.NIASO_14785 6.49e-08 51.6 COG0789@1|root,COG0789@2|Bacteria,4NSBD@976|Bacteroidetes,1IY5A@117747|Sphingobacteriia 976|Bacteroidetes K helix_turn_helix, mercury resistance ycgE - - - - - - - - - - - MerR_1 k59_381816_1 1112274.KI911560_gene373 4.31e-47 171.0 COG1511@1|root,COG1511@2|Bacteria,1R1ET@1224|Proteobacteria,2WI1W@28216|Betaproteobacteria,2KM58@206350|Nitrosomonadales 206350|Nitrosomonadales S haemagglutination activity domain - - - - - - - - - - - - DUF3739,ESPR,Haemagg_act k59_311302_1 1123257.AUFV01000009_gene2158 1.61e-168 473.0 COG1403@1|root,COG1403@2|Bacteria,1N09C@1224|Proteobacteria,1S9NB@1236|Gammaproteobacteria,1XBFZ@135614|Xanthomonadales 135614|Xanthomonadales V HNH endonuclease - - - - - - - - - - - - - k59_311302_2 1123257.AUFV01000009_gene2159 0.000597 41.6 COG3950@1|root,COG3950@2|Bacteria,1NT0V@1224|Proteobacteria,1RXY6@1236|Gammaproteobacteria,1X94Z@135614|Xanthomonadales 135614|Xanthomonadales S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 k59_412969_1 29581.BW37_00916 4.55e-55 191.0 COG3369@1|root,COG3369@2|Bacteria,1RE35@1224|Proteobacteria,2VYSW@28216|Betaproteobacteria 28216|Betaproteobacteria S Ferritin-like - - - - - - - - - - - - Ferritin-like k59_463181_2 1159870.KB907784_gene537 8.38e-25 105.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1R5F7@1224|Proteobacteria,2W90Q@28216|Betaproteobacteria,3T7R1@506|Alcaligenaceae 1224|Proteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - EAL,GAF_2,GGDEF,Protoglobin k59_588924_1 1454004.AW11_02657 3.42e-42 152.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria 28216|Betaproteobacteria P PFAM NnrS family protein - - - ko:K07234 - - - - ko00000 - - - NnrS k59_1062034_1 243233.MCA0588 6.47e-09 57.4 COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,1XFA2@135618|Methylococcales 135618|Methylococcales K response regulator - - - ko:K07183 - - - - ko00000,ko02022 - - - ANTAR,Response_reg k59_164542_1 614083.AWQR01000038_gene1421 4.79e-128 391.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,4ABMR@80864|Comamonadaceae 28216|Betaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_381851_1 640081.Dsui_2821 1.89e-29 115.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2WEJI@28216|Betaproteobacteria,2KUP5@206389|Rhodocyclales 206389|Rhodocyclales P Ion channel - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_381851_2 338969.Rfer_3964 6.51e-33 117.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,2VTZE@28216|Betaproteobacteria,4AEE4@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0225 family ychJ - - ko:K09858 - - - - ko00000 - - - SEC-C k59_678115_1 1000565.METUNv1_01320 7.82e-141 404.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,2KV36@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_678115_2 1000565.METUNv1_01319 4.67e-222 618.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,2KUDN@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_678115_3 1000565.METUNv1_01318 5.36e-65 209.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,2KVCM@206389|Rhodocyclales 206389|Rhodocyclales NU twitching motility protein - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_487498_1 43989.cce_4650 1.47e-31 127.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3KFYI@43988|Cyanothece 1117|Cyanobacteria T GGDEF domain - - - - - - - - - - - - EAL,FHA,GGDEF,Response_reg k59_534941_1 640081.Dsui_2443 6.54e-34 122.0 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,2VUIG@28216|Betaproteobacteria,2KX2U@206389|Rhodocyclales 206389|Rhodocyclales S metal-binding, possibly nucleic acid-binding protein - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_734594_1 595537.Varpa_1014 8.87e-102 299.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,4ADJC@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM N-acetylmuramoyl-L-alanine amidase family 2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_1125603_1 1000565.METUNv1_02157 2.3e-18 79.0 2ETMM@1|root,33M5D@2|Bacteria,1NJIU@1224|Proteobacteria,2VYX1@28216|Betaproteobacteria,2KXH1@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1125603_2 1000565.METUNv1_02156 3.44e-113 332.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,2KVPQ@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_463263_1 616991.JPOO01000003_gene2346 4.4e-08 60.5 COG1524@1|root,COG1524@2|Bacteria,4NIUS@976|Bacteroidetes,1HZKJ@117743|Flavobacteriia,23HQN@178469|Arenibacter 976|Bacteroidetes S Metalloenzyme superfamily - - - - - - - - - - - - CHB_HEX_C_1,PA14,Phosphodiest k59_311369_1 1100721.ALKO01000017_gene1560 2.15e-184 532.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,4AAKB@80864|Comamonadaceae 28216|Betaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_128398_1 29581.BW37_04048 1.14e-140 421.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2VM87@28216|Betaproteobacteria,47405@75682|Oxalobacteraceae 28216|Betaproteobacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_1021908_2 864051.BurJ1DRAFT_4640 1.82e-74 231.0 COG0745@1|root,COG0745@2|Bacteria,1QWG0@1224|Proteobacteria,2WGYI@28216|Betaproteobacteria,1KPDN@119065|unclassified Burkholderiales 28216|Betaproteobacteria KT Helix-turn-helix domain - - - - - - - - - - - - HTH_17,Response_reg k59_413020_1 1120977.JHUX01000005_gene2696 1.58e-57 201.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,3NJ42@468|Moraxellaceae 1236|Gammaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_4025 PEPcase k59_767879_2 1122201.AUAZ01000021_gene3149 2.49e-67 238.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_844012_2 287.DR97_830 3.6e-06 50.8 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T1IV@1236|Gammaproteobacteria,1YKP2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K21022 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_844020_1 595537.Varpa_2089 6.75e-39 147.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,4AB5U@80864|Comamonadaceae 28216|Betaproteobacteria T SMART Nucleotide binding protein, PINc phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_1021935_1 326427.Cagg_3114 5.52e-08 58.5 COG0500@1|root,COG2226@2|Bacteria,2GA7Z@200795|Chloroflexi,375F2@32061|Chloroflexia 32061|Chloroflexia Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_23 k59_1095164_1 1123487.KB892835_gene3413 1.14e-10 66.6 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KU84@206389|Rhodocyclales 206389|Rhodocyclales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,MCPsignal k59_534997_1 984262.SGRA_2047 1.15e-05 47.0 COG0327@1|root,COG0327@2|Bacteria,4NF51@976|Bacteroidetes,1IP4G@117747|Sphingobacteriia 976|Bacteroidetes S Belongs to the GTP cyclohydrolase I type 2 NIF3 family yqfO - - - - - - - - - - - NIF3 k59_534997_2 661478.OP10G_4123 1.62e-08 60.1 COG2317@1|root,COG2317@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity ypwA - 3.4.17.19 ko:K01299,ko:K03281 - - - - ko00000,ko01000,ko01002 2.A.49 - - Peptidase_M32 k59_1125636_1 1366050.N234_08680 1.52e-27 111.0 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2VT0Q@28216|Betaproteobacteria,1KHIB@119060|Burkholderiaceae 28216|Betaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_21641_1 160492.XF_0705 4.67e-30 124.0 COG3378@1|root,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,1RRN5@1236|Gammaproteobacteria,1X4S3@135614|Xanthomonadales 135614|Xanthomonadales S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_1125639_2 614083.AWQR01000005_gene1223 5.28e-72 228.0 COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,2VJWZ@28216|Betaproteobacteria,4AD20@80864|Comamonadaceae 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_463324_1 365046.Rta_04260 2.15e-67 215.0 COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2VJES@28216|Betaproteobacteria,4ACZN@80864|Comamonadaceae 28216|Betaproteobacteria E L-asparaginase II - - - - - - - - - - - - Asparaginase_II k59_311415_1 1120977.JHUX01000004_gene2367 9.82e-111 334.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,3NIQS@468|Moraxellaceae 1236|Gammaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_381969_2 1397527.Q670_05275 2.81e-116 337.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1XHCC@135619|Oceanospirillales 135619|Oceanospirillales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_624030_1 543728.Vapar_5097 1.63e-48 164.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,4AC31@80864|Comamonadaceae 28216|Betaproteobacteria G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_624030_2 338969.Rfer_0203 5.9e-46 155.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,4AB7S@80864|Comamonadaceae 28216|Betaproteobacteria F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_736473_1 1353529.M899_0461 1.2e-67 214.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2MTQF@213481|Bdellovibrionales,2WJDT@28221|Deltaproteobacteria 213481|Bdellovibrionales M PFAM NAD-dependent epimerase dehydratase - - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_313983_1 471874.PROSTU_03118 1.92e-101 318.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,3Z8FA@586|Providencia 1236|Gammaproteobacteria C NADH dehydrogenase I chain G (NADH-ubiquinone oxidoreductase chain G) (NUO7) K00336 nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iECs_1301.ECs3167,iG2583_1286.G2583_2820,iZ_1308.Z3542 Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_624047_1 614083.AWQR01000029_gene2155 4.84e-31 111.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,4ADYR@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver pilG - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_59785_1 358220.C380_12645 1.95e-07 52.4 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,4AA4B@80864|Comamonadaceae 28216|Betaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_59785_2 365046.Rta_21910 2.8e-46 153.0 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,4ADYK@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR exbD2 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_846434_1 1321775.HMPREF1980_01451 2.01e-26 113.0 COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4D3DP@85005|Actinomycetales 201174|Actinobacteria GM ABC transporter, ATP-binding protein rfbB2 - 3.6.3.40 ko:K01990,ko:K09691,ko:K09693 ko02010,map02010 M00250,M00251,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.103,3.A.1.104 - - ABC_tran,Wzt_C k59_609989_2 522306.CAP2UW1_4457 1.12e-70 216.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,2VI7T@28216|Betaproteobacteria,1KQ43@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Redoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_328201_1 1000565.METUNv1_02417 2.22e-88 265.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,2KUXY@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_328201_2 1000565.METUNv1_02418 9.59e-35 125.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,2KUIX@206389|Rhodocyclales 206389|Rhodocyclales Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_362165_1 1097668.BYI23_E002200 4.23e-86 261.0 COG2801@1|root,COG2801@2|Bacteria,1PUMN@1224|Proteobacteria,2VKGM@28216|Betaproteobacteria,1K4P1@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - rve k59_217665_2 1120999.JONM01000034_gene3998 6.44e-32 119.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,2VNPZ@28216|Betaproteobacteria,2KSH7@206351|Neisseriales 206351|Neisseriales K Bacterial transcription activator, effector binding domain - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 k59_291116_1 1218075.BAYA01000010_gene3273 6.66e-71 219.0 COG1028@1|root,COG1028@2|Bacteria,1R756@1224|Proteobacteria,2VPN8@28216|Betaproteobacteria,1K12A@119060|Burkholderiaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_291116_2 196367.JNFG01000215_gene765 9.72e-18 82.0 COG0531@1|root,COG0531@2|Bacteria,1MX13@1224|Proteobacteria,2VM9H@28216|Betaproteobacteria,1K3CY@119060|Burkholderiaceae 28216|Betaproteobacteria E Amino acid permease-associated region - - - - - - - - - - - - AA_permease_2 k59_506813_1 864051.BurJ1DRAFT_3978 4.87e-29 117.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KK5X@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_506813_2 1120999.JONM01000010_gene4112 1.4e-13 74.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria 1224|Proteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406,ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PAS_3 k59_255105_1 1198452.Jab_1c04480 1.86e-20 90.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,475P3@75682|Oxalobacteraceae 28216|Betaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_111382_2 204773.HEAR1127 8.73e-110 328.0 COG0500@1|root,COG2226@2|Bacteria,1RERY@1224|Proteobacteria 1224|Proteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_41026_1 1000565.METUNv1_02529 6.81e-216 629.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,2KUW5@206389|Rhodocyclales 206389|Rhodocyclales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_398290_1 296591.Bpro_2317 3.1e-45 160.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,4AAYC@80864|Comamonadaceae 28216|Betaproteobacteria H TIGRFAM acetolactate synthase, large subunit, biosynthetic type ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_291133_1 1000565.METUNv1_00697 1.12e-209 596.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,2KVUA@206389|Rhodocyclales 206389|Rhodocyclales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_506840_1 1000565.METUNv1_00649 3.01e-45 155.0 COG2199@1|root,COG3706@2|Bacteria,1MVWM@1224|Proteobacteria,2VNDI@28216|Betaproteobacteria,2KYJZ@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_111390_1 522306.CAP2UW1_4188 6.98e-58 185.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria 28216|Betaproteobacteria NU PFAM Fimbrial assembly family protein pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_111390_2 1000565.METUNv1_01938 2.06e-118 345.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,2KV8N@206389|Rhodocyclales 206389|Rhodocyclales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_931800_1 700598.Niako_6901 2.93e-108 332.0 COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,1IQFU@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1004095_1 1000565.METUNv1_00273 2.23e-94 296.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - DUF2222,HATPase_c,HisKA,Response_reg,dCache_1 k59_1040449_1 202952.BBLI01000001_gene97 9.04e-91 274.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,3NJZS@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718 LIAS_N,Radical_SAM k59_753557_1 323848.Nmul_A1399 8.6e-59 199.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria 28216|Betaproteobacteria S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_111392_1 1000565.METUNv1_02581 3.19e-137 407.0 28IWG@1|root,2Z8US@2|Bacteria,1NHDW@1224|Proteobacteria,2VPYM@28216|Betaproteobacteria,2KY8N@206389|Rhodocyclales 206389|Rhodocyclales S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_398307_1 614083.AWQR01000029_gene2136 2.58e-13 69.3 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,4AABC@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefC - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_506860_1 521674.Plim_3506 8.05e-30 120.0 COG1520@1|root,COG1520@2|Bacteria,2IY7A@203682|Planctomycetes 203682|Planctomycetes S COG1520 FOG WD40-like repeat - - - - - - - - - - - - PQQ_2,PQQ_3 k59_328272_1 1198452.Jab_1c03100 3.86e-162 465.0 COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,475J2@75682|Oxalobacteraceae 28216|Betaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_469014_1 765911.Thivi_0695 1.95e-85 281.0 COG2202@1|root,COG3614@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXCR@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CHASE,CZB,EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_362208_1 1000565.METUNv1_00399 2.39e-118 341.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,2KW5Z@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_931804_1 159087.Daro_0675 2.41e-190 559.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_76003_2 290317.Cpha266_1749 2.89e-81 263.0 COG4618@1|root,COG4618@2|Bacteria,1FD9W@1090|Chlorobi 1090|Chlorobi V TIGRFAM type I secretion system ATPase - - - ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran k59_682122_2 338969.Rfer_2461 3.69e-73 219.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,4AEDX@80864|Comamonadaceae 28216|Betaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_10,Fer4_4 k59_682122_3 338969.Rfer_2460 5.61e-12 65.1 COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,4A9K7@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.7.4 ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - GTP_EFTU,GTP_EFTU_D2 k59_255148_1 1120977.JHUX01000003_gene647 1.56e-76 254.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,3NJS6@468|Moraxellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_790507_1 497321.C664_06758 2.78e-117 346.0 COG0348@1|root,COG0348@2|Bacteria,1MUWD@1224|Proteobacteria,2VMUP@28216|Betaproteobacteria,2KUX9@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 k59_1040471_1 697282.Mettu_0664 1.11e-92 307.0 COG0642@1|root,COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_506894_1 1000565.METUNv1_01537 2.09e-111 345.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,2KVJ1@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_506901_1 1123487.KB892863_gene1953 5.26e-29 119.0 COG0642@1|root,COG0784@1|root,COG2197@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2197@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,2KZWN@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_255164_1 1124982.MSI_21250 3.87e-19 87.0 COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes 203691|Spirochaetes V Methicillin resistance protein femA - - - - - - - - - - - FemAB k59_255164_2 1380390.JIAT01000010_gene4767 3.55e-30 109.0 COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4CT9K@84995|Rubrobacteria 84995|Rubrobacteria S Uncharacterized conserved protein (DUF2277) - - - - - - - - - - - - DUF2277 k59_398341_1 1000565.METUNv1_02119 3.22e-48 171.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KUKW@206389|Rhodocyclales 206389|Rhodocyclales V AcrB/AcrD/AcrF family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_398341_2 1000565.METUNv1_02118 2.07e-85 263.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KVSS@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_931822_1 1177181.T9A_02006 1.43e-12 63.5 2EHCH@1|root,33B4C@2|Bacteria,1NQ35@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_931822_2 95619.PM1_0209610 1.54e-40 145.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_469031_1 1000565.METUNv1_00331 1.02e-33 123.0 COG5581@1|root,COG5581@2|Bacteria,1RFI4@1224|Proteobacteria,2VS7C@28216|Betaproteobacteria,2KWST@206389|Rhodocyclales 206389|Rhodocyclales M Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility ycgR - - - - - - - - - - - PilZ,YcgR k59_469031_2 1000565.METUNv1_00332 5.67e-52 165.0 COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,2VTYF@28216|Betaproteobacteria,2KX19@206389|Rhodocyclales 206389|Rhodocyclales N cytoplasmic domain of flagellar protein FhlB - - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 k59_469031_3 1000565.METUNv1_00333 3.01e-132 392.0 COG3144@1|root,COG3144@2|Bacteria,1N0CE@1224|Proteobacteria,2VQG2@28216|Betaproteobacteria,2KW7V@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar hook-length control protein FliK - - - - - - - - - - - - Flg_hook k59_469031_4 1000565.METUNv1_00334 3.43e-44 145.0 2DK6J@1|root,308QQ@2|Bacteria,1NPSX@1224|Proteobacteria,2VZ2E@28216|Betaproteobacteria,2KXHC@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar protein FliT - - - ko:K02423 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliT k59_217697_1 1000565.METUNv1_00660 0.0 946.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - 4HB_MCP_1,CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_7,PAS_8,PAS_9,Response_reg k59_574963_1 1000565.METUNv1_02591 6.9e-11 61.2 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,2KU9A@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_506912_1 166318.Syn8016DRAFT_1993 3.85e-24 104.0 COG2201@1|root,COG2201@2|Bacteria,1GJ7G@1117|Cyanobacteria,1H1FB@1129|Synechococcus 1117|Cyanobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_506912_2 595460.RRSWK_06762 2.76e-26 100.0 COG2199@1|root,COG3706@2|Bacteria,2J0C7@203682|Planctomycetes 203682|Planctomycetes T response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_4574_2 1005048.CFU_4301 1.11e-55 180.0 COG2128@1|root,COG2128@2|Bacteria,1MWWX@1224|Proteobacteria,2VV44@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_539566_1 545276.KB898730_gene1444 4.88e-07 55.8 COG3091@1|root,COG3091@2|Bacteria,1RBMK@1224|Proteobacteria,1S3MT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SprT-like family - - - - - - - - - - - - SprT-like k59_1040491_1 1000565.METUNv1_04045 5.62e-207 645.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_76051_2 1000565.METUNv1_00180 1.52e-104 309.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,2KU8H@206389|Rhodocyclales 206389|Rhodocyclales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_753593_1 1366050.N234_15595 2.46e-06 49.3 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VKWQ@28216|Betaproteobacteria,1JZNW@119060|Burkholderiaceae 28216|Betaproteobacteria G Class II aldolase adducin family protein - - - - - - - - - - - - Aldolase_II k59_753593_2 598467.BrE312_0321 1.27e-59 199.0 COG0765@1|root,COG1126@1|root,COG0765@2|Bacteria,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria E (ABC) transporter - - 3.6.3.21 ko:K02028,ko:K02029 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran,BPD_transp_1 k59_539571_1 29581.BW37_04923 3.93e-69 222.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2VIP0@28216|Betaproteobacteria,472AE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_790533_1 1000565.METUNv1_00092 2.23e-53 181.0 COG0666@1|root,COG0666@2|Bacteria,1R76J@1224|Proteobacteria,2VP42@28216|Betaproteobacteria,2KV0E@206389|Rhodocyclales 206389|Rhodocyclales S Ankyrin repeat - - - - - - - - - - - - Ank_4 k59_790533_2 1000565.METUNv1_00091 6.25e-52 170.0 COG0810@1|root,COG0810@2|Bacteria,1NANH@1224|Proteobacteria,2VWBS@28216|Betaproteobacteria,2KXDG@206389|Rhodocyclales 206389|Rhodocyclales M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_790533_3 1000565.METUNv1_00089 1.66e-20 87.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,2KUR3@206389|Rhodocyclales 206389|Rhodocyclales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_328353_1 1223521.BBJX01000009_gene1101 4.99e-91 273.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,4ACSW@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Enoyl-CoA hydratase isomerase fadB3 - - - - - - - - - - - ECH_1 k59_718776_2 1000565.METUNv1_02982 1.36e-85 274.0 COG0515@1|root,COG2114@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,2KWHB@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein kinase domain - - - - - - - - - - - - DUF4384,Pkinase k59_111450_1 1211115.ALIQ01000043_gene2974 1.52e-07 58.5 COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,2U0RV@28211|Alphaproteobacteria,3NCPK@45404|Beijerinckiaceae 28211|Alphaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_328377_2 999550.KI421507_gene2094 8.48e-11 63.5 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria 28211|Alphaproteobacteria V N-acetylmuramoyl-L-alanine amidase ampD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 2.5.1.3,3.5.1.28 ko:K00788,ko:K01447,ko:K03806,ko:K11066 ko00730,ko01100,map00730,map01100 M00127 R03223,R04112,R10712 RC00064,RC00141,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Amidase_2,PG_binding_1 k59_399327_1 1000565.METUNv1_01247 6.3e-79 241.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,2KUJ3@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_399327_2 1550073.JROH01000091_gene1948 4.3e-25 97.1 2C39R@1|root,32UYY@2|Bacteria,1N8ND@1224|Proteobacteria,2UFIK@28211|Alphaproteobacteria,2K6XH@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_399327_3 1000565.METUNv1_01245 7.98e-160 456.0 COG4974@1|root,COG4974@2|Bacteria,1PZTE@1224|Proteobacteria,2VMKS@28216|Betaproteobacteria,2KW77@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_147538_1 522306.CAP2UW1_0279 3.1e-43 149.0 COG1414@1|root,COG1414@2|Bacteria,1Q7BI@1224|Proteobacteria,2VK7Y@28216|Betaproteobacteria,1KQPT@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR,IclR k59_147538_2 159087.Daro_0805 6.79e-106 309.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VPQ9@28216|Betaproteobacteria,2M01K@206389|Rhodocyclales 206389|Rhodocyclales D ATPase MipZ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - CbiA k59_218216_1 1000565.METUNv1_02153 2.92e-76 257.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KYID@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_1111109_1 1121271.AUCM01000027_gene99 3.12e-42 152.0 COG0494@1|root,COG0494@2|Bacteria,1N9YQ@1224|Proteobacteria,2UKM6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L nUDIX hydrolase - - - - - - - - - - - - NUDIX k59_112190_1 545695.TREAZ_1221 6.07e-40 140.0 COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes 203691|Spirochaetes IQ PFAM Short-chain dehydrogenase reductase SDR fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_112190_2 665571.STHERM_c21540 1.14e-13 69.3 COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes 203691|Spirochaetes IQ PFAM Short-chain dehydrogenase reductase SDR fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_875744_1 1121022.ABENE_22440 1.26e-14 68.2 COG3668@1|root,COG3668@2|Bacteria,1PZJP@1224|Proteobacteria,2V56Q@28211|Alphaproteobacteria,2KJFD@204458|Caulobacterales 204458|Caulobacterales S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_875744_2 1449065.JMLL01000011_gene2120 3.74e-05 51.2 COG3904@1|root,COG3904@2|Bacteria,1R4PW@1224|Proteobacteria,2U3UG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S periplasmic protein - - - - - - - - - - - - - k59_377887_1 159087.Daro_2224 1.79e-18 82.8 COG2135@1|root,COG2135@2|Bacteria,1RJ1S@1224|Proteobacteria,2WFH7@28216|Betaproteobacteria,2KXD8@206389|Rhodocyclales 206389|Rhodocyclales E SOS response associated peptidase (SRAP) - - - - - - - - - - - - SRAP k59_90091_1 795666.MW7_2947 4.65e-293 835.0 COG1200@1|root,COG1200@2|Bacteria,1QWSU@1224|Proteobacteria,2VPIB@28216|Betaproteobacteria 28216|Betaproteobacteria KL Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C k59_554222_1 1000565.METUNv1_03387 6.99e-119 353.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUDD@206389|Rhodocyclales 206389|Rhodocyclales S of ABC transporters with duplicated ATPase ybiT - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_1018734_1 582744.Msip34_1055 6.4e-47 172.0 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2VJ6I@28216|Betaproteobacteria,2KMFZ@206350|Nitrosomonadales 206350|Nitrosomonadales M AsmA-like C-terminal region - - - ko:K07289,ko:K07290 - - - - ko00000 9.B.121 - - AsmA k59_458900_1 42256.RradSPS_2663 1.5e-36 140.0 COG2202@1|root,COG2204@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4CT8E@84995|Rubrobacteria 84995|Rubrobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9,Response_reg k59_458900_2 1123368.AUIS01000004_gene121 2.89e-11 60.8 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,1T3Z8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator receiver - - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg k59_410500_1 640081.Dsui_2937 4.99e-73 233.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,2KURP@206389|Rhodocyclales 206389|Rhodocyclales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_530348_1 1332071.L581_1104 3.74e-51 166.0 COG0824@1|root,COG0824@2|Bacteria,1MZBM@1224|Proteobacteria,1SD0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_554238_1 1237149.C900_00705 5.7e-05 46.6 COG0705@1|root,COG0705@2|Bacteria,4NIYR@976|Bacteroidetes,47PBZ@768503|Cytophagia 976|Bacteroidetes S PFAM Rhomboid family - - 3.4.21.105 ko:K09650 - - - - ko00000,ko01000,ko01002,ko03029 - - - Rhomboid k59_554238_2 485918.Cpin_0862 4.12e-49 169.0 COG2265@1|root,COG2265@2|Bacteria,4NFP1@976|Bacteroidetes,1IQPD@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_911042_1 1458275.AZ34_03585 4.62e-111 334.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,4AC6F@80864|Comamonadaceae 28216|Betaproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_840741_2 987059.RBXJA2T_15588 1.14e-28 118.0 COG0642@1|root,COG0834@1|root,COG2461@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJCZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_55193_1 1000565.METUNv1_01138 5.06e-42 154.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,2KUU5@206389|Rhodocyclales 206389|Rhodocyclales T EAL domain - - - - - - - - - - - - EAL,GGDEF k59_55193_2 305700.B447_03163 7.29e-20 89.7 COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,2KV8I@206389|Rhodocyclales 206389|Rhodocyclales CI Bifunctional enoyl-CoA hydratase phosphate acetyltransferase pta - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas,PTA_PTB k59_805716_1 1100720.ALKN01000044_gene2090 6.48e-95 287.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,4AC1Q@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family bktB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_484266_1 1502852.FG94_04681 6.69e-37 128.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2VU9V@28216|Betaproteobacteria,474V8@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor bigR - - - - - - - - - - - HTH_5 k59_484266_2 358220.C380_12015 6.73e-27 101.0 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,4AEJS@80864|Comamonadaceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_270371_1 365046.Rta_08560 5.9e-113 333.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VIJP@28216|Betaproteobacteria,4AADC@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_484269_1 1110502.TMO_2048 7.79e-06 50.8 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPM5@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2,DUF3382 k59_484269_2 1123355.JHYO01000007_gene485 1.43e-28 110.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,36X2R@31993|Methylocystaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component livH GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1057830_2 1000565.METUNv1_00887 2.38e-55 174.0 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,2VW2I@28216|Betaproteobacteria,2KX73@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_911065_1 640081.Dsui_1209 2.98e-82 262.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,2KVA2@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_943778_1 296591.Bpro_1111 2.99e-46 166.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,2WHEY@28216|Betaproteobacteria,4AJW2@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_554293_1 93220.LV28_02220 2.67e-83 255.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VHZ4@28216|Betaproteobacteria,1K1RM@119060|Burkholderiaceae 28216|Betaproteobacteria S alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N k59_1057860_1 948565.AFFP02000008_gene1774 9.08e-36 129.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1Y703@135625|Pasteurellales 135625|Pasteurellales O C-terminal region of band_7 qmcA - - - - - - - - - - - Band_7,Band_7_C k59_1057860_2 1112217.PPL19_14569 1.86e-09 57.8 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_90168_1 83406.HDN1F_04230 5.01e-136 399.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_1123038_1 1000565.METUNv1_01488 6.51e-90 295.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,2KVQ5@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl k59_1093426_1 1000565.METUNv1_02936 1.27e-109 317.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2VIFV@28216|Betaproteobacteria,2KUW6@206389|Rhodocyclales 206389|Rhodocyclales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_732182_2 946483.Cenrod_1359 6.52e-41 147.0 COG3664@1|root,COG3664@2|Bacteria,1MX9Q@1224|Proteobacteria,2W20Q@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM glycoside hydrolase family 39 - - - - - - - - - - - - - k59_911090_1 1218075.BAYA01000004_gene1269 7.46e-47 166.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_484310_1 391615.ABSJ01000016_gene1726 3.95e-107 315.0 COG3687@1|root,COG3687@2|Bacteria,1RBP4@1224|Proteobacteria,1RZJF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_351711_1 925409.KI911562_gene2027 1.32e-107 333.0 COG3391@1|root,COG3391@2|Bacteria,4NER2@976|Bacteroidetes,1IQ4S@117747|Sphingobacteriia 976|Bacteroidetes M 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase,Phosphoesterase k59_229179_1 596154.Alide2_3760 1.88e-31 116.0 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,2VSGZ@28216|Betaproteobacteria,4ADKX@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0307 family yjgA - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_229179_2 1268622.AVS7_01298 8.5e-66 204.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2VH28@28216|Betaproteobacteria,4AAVY@80864|Comamonadaceae 28216|Betaproteobacteria H Molybdenum cofactor synthesis domain mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_90185_1 1144275.COCOR_02595 5.5e-49 177.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - ko:K16416 ko01052,map01052 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_530477_1 925409.KI911562_gene1561 1.93e-59 192.0 COG0142@1|root,COG0142@2|Bacteria,4NET2@976|Bacteroidetes,1INM5@117747|Sphingobacteriia 976|Bacteroidetes H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_765585_1 674977.VMC_08760 7.79e-28 112.0 COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,1RNEY@1236|Gammaproteobacteria,1XUE2@135623|Vibrionales 135623|Vibrionales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_351733_1 1000565.METUNv1_03425 1.05e-97 311.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY9@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_351733_2 1000565.METUNv1_03426 4.15e-14 67.0 COG0347@1|root,COG0347@2|Bacteria,1N32M@1224|Proteobacteria,2VUEY@28216|Betaproteobacteria,2KWXV@206389|Rhodocyclales 206389|Rhodocyclales K Nitrogen regulatory protein P-II - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_90200_1 1408473.JHXO01000011_gene3152 9.12e-32 130.0 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,2FM3C@200643|Bacteroidia 976|Bacteroidetes G Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_16,TPR_2,TPR_21,TPR_6,TPR_8 k59_351751_1 1267535.KB906767_gene5033 3.68e-32 116.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZR@57723|Acidobacteria,2JK6A@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_351762_1 232721.Ajs_2362 3.21e-35 132.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria,4AC10@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM ABC-2 type transporter yhhJ - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_307999_1 1000565.METUNv1_00061 9.31e-76 243.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VHHU@28216|Betaproteobacteria,2KVK7@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_620604_2 697282.Mettu_1714 1.6e-60 192.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1S4DQ@1236|Gammaproteobacteria,1XGEI@135618|Methylococcales 135618|Methylococcales NT SMART CheW-like protein - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_620604_3 454957.IA64_06165 1.13e-09 62.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_4,sCache_2 k59_943856_1 748247.AZKH_0339 6.3e-72 229.0 COG1333@1|root,COG1333@2|Bacteria,1RKRF@1224|Proteobacteria,2VTE4@28216|Betaproteobacteria 28216|Betaproteobacteria O cytochrome c biogenesis protein - - - ko:K07399 - - - - ko00000 - - - ResB k59_840886_1 614083.AWQR01000003_gene2918 1.75e-36 137.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,4ABKD@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_1018897_1 1157708.KB907450_gene5441 0.000205 52.0 COG5434@1|root,COG5434@2|Bacteria,1RCW1@1224|Proteobacteria,2W4G2@28216|Betaproteobacteria 28216|Betaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_1018897_3 247490.KSU1_C0123 8.58e-51 184.0 COG0151@1|root,COG0151@2|Bacteria 2|Bacteria F phosphoribosylamine-glycine ligase activity purD - 6.3.4.13,6.3.5.5 ko:K01945,ko:K01955 ko00230,ko00240,ko00250,ko01100,ko01110,ko01130,map00230,map00240,map00250,map01100,map01110,map01130 M00048,M00051 R00256,R00575,R01395,R04144,R10948,R10949 RC00002,RC00010,RC00043,RC00090,RC00166,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3,GARS_A,GARS_C,GARS_N k59_695744_1 365046.Rta_09860 2.47e-20 87.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,4AA9U@80864|Comamonadaceae 28216|Betaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_695744_2 1217718.ALOU01000069_gene4837 6.95e-25 101.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2VKA8@28216|Betaproteobacteria 28216|Betaproteobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD2 - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_911179_1 700598.Niako_0736 6.38e-28 114.0 COG2335@1|root,COG2335@2|Bacteria,4NI6Z@976|Bacteroidetes,1IQ5T@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function - - - - - - - - - - - - DUF4993,Fasciclin k59_55341_1 289376.THEYE_A1265 4.32e-64 205.0 COG0152@1|root,COG0152@2|Bacteria,3J0U6@40117|Nitrospirae 40117|Nitrospirae F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_805849_1 925409.KI911562_gene2992 6.91e-47 163.0 COG0519@1|root,COG0519@2|Bacteria,4NESX@976|Bacteroidetes,1INX4@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_805849_2 925409.KI911562_gene2991 2.25e-10 61.6 COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,1ITBV@117747|Sphingobacteriia 976|Bacteroidetes S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_484427_1 1121035.AUCH01000019_gene2866 1.05e-114 340.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,2KV2N@206389|Rhodocyclales 206389|Rhodocyclales G Tripartite ATP-independent periplasmic transporter, DctM component - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_676499_1 1000565.METUNv1_00768 1.24e-111 347.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_486377_1 768671.ThimaDRAFT_3742 8.37e-15 79.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1WZ5E@135613|Chromatiales 135613|Chromatiales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_588132_1 1100720.ALKN01000044_gene1997 3.24e-86 268.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2WH5F@28216|Betaproteobacteria,4ABYG@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_310158_1 1144319.PMI16_03728 3.69e-103 303.0 COG3295@1|root,COG3295@2|Bacteria,1R9YV@1224|Proteobacteria,2VKI1@28216|Betaproteobacteria,473TJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative PepSY_TM-like - - - ko:K09939 - - - - ko00000 - - - PepSY_TM_like_2 k59_310158_2 29581.BW37_02740 9.99e-17 79.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,472BG@75682|Oxalobacteraceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_676502_1 466038.KI421440_gene1270 9.83e-07 56.6 COG4122@1|root,COG4122@2|Bacteria,1RHWY@1224|Proteobacteria,2UN19@28211|Alphaproteobacteria,4BT1A@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_945285_1 1120999.JONM01000005_gene3961 1.24e-07 53.5 COG0642@1|root,COG0840@1|root,COG0840@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VPUH@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_945285_2 595494.Tola_1053 1.81e-53 174.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1Y4P1@135624|Aeromonadales 135624|Aeromonadales H riboflavin synthase, alpha - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_1094529_1 759914.BP951000_1252 3.73e-33 130.0 COG0210@1|root,COG0210@2|Bacteria,2J5T4@203691|Spirochaetes 203691|Spirochaetes L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_767055_1 614083.AWQR01000029_gene2123 2.75e-07 48.1 2E53D@1|root,32ZWH@2|Bacteria,1N979@1224|Proteobacteria,2VVRY@28216|Betaproteobacteria,4AFBB@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_767055_2 887062.HGR_08684 1.07e-81 249.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,4AA6B@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_807431_1 66429.JOFL01000004_gene3521 2.02e-14 73.6 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria 201174|Actinobacteria P Flavoprotein involved in K transport - GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0055114 - - - - - - - - - - FMO-like,Pyr_redox_3 k59_127468_1 365046.Rta_37170 8.28e-71 228.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae 28216|Betaproteobacteria S FAD dependent oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_210404_1 595537.Varpa_0213 2.18e-92 276.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VI2N@28216|Betaproteobacteria,4ABV4@80864|Comamonadaceae 28216|Betaproteobacteria E ABC transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_714381_1 1000565.METUNv1_01999 3.25e-90 279.0 COG0840@1|root,COG0840@2|Bacteria,1R5W9@1224|Proteobacteria,2VKQP@28216|Betaproteobacteria,2KVCX@206389|Rhodocyclales 206389|Rhodocyclales NT Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB,MCPsignal k59_714381_2 640081.Dsui_0314 1.73e-05 52.4 COG3087@1|root,COG3087@2|Bacteria,1NED8@1224|Proteobacteria,2VWRX@28216|Betaproteobacteria,2KX45@206389|Rhodocyclales 206389|Rhodocyclales D Sporulation related domain - - - - - - - - - - - - SPOR k59_1035577_1 1000565.METUNv1_02552 5.33e-159 447.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,2KUDT@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases fnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1035577_2 1000565.METUNv1_02553 0.0 865.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,2KVK4@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_643161_1 1000565.METUNv1_02464 6.19e-257 715.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,2KUIC@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M48 - - - - - - - - - - - - Peptidase_M48,TPR_16,TPR_19 k59_250355_1 1000565.METUNv1_02932 3.19e-146 415.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,2KUF5@206389|Rhodocyclales 206389|Rhodocyclales H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_321897_1 1184609.KILIM_034_00340 5.52e-82 271.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F67N@85018|Dermatophilaceae 201174|Actinobacteria L DNA polymerase alpha chain like domain dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1071473_1 1122605.KB893626_gene2352 4.35e-60 189.0 2DRKN@1|root,33C6H@2|Bacteria,4NZAT@976|Bacteroidetes,1ITIX@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_107493_2 1000565.METUNv1_02902 3.85e-69 210.0 COG4290@1|root,COG4290@2|Bacteria,1MZEZ@1224|Proteobacteria,2VTZ7@28216|Betaproteobacteria,2KWVU@206389|Rhodocyclales 206389|Rhodocyclales F Guanyl-specific ribonuclease Sa - - - - - - - - - - - - Ribonuclease k59_107493_3 580332.Slit_0975 4.58e-12 66.6 COG2732@1|root,COG2732@2|Bacteria,1PCTM@1224|Proteobacteria,2WA4A@28216|Betaproteobacteria,44WMH@713636|Nitrosomonadales 28216|Betaproteobacteria K Barstar (barnase inhibitor) - - - - - - - - - - - - Barstar k59_107493_4 1000565.METUNv1_02904 0.000136 42.4 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,2KWKI@206389|Rhodocyclales 206389|Rhodocyclales L NUDIX domain - - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_571433_1 987059.RBXJA2T_14721 2.8e-25 103.0 COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2VHNW@28216|Betaproteobacteria,1KJ3A@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Cys/Met metabolism PLP-dependent enzyme metC - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_571433_2 614083.AWQR01000005_gene1062 1.08e-33 122.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VHU8@28216|Betaproteobacteria,4ABDR@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family fabG3 - - - - - - - - - - - adh_short,adh_short_C2 k59_214550_1 1000565.METUNv1_02694 0.0 1215.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KVNE@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_214550_2 1366050.N234_03960 2.23e-20 85.9 COG1132@1|root,COG1132@2|Bacteria,1RDIA@1224|Proteobacteria,2VR6J@28216|Betaproteobacteria,1K8XS@119060|Burkholderiaceae 28216|Betaproteobacteria V Domain of unknown function (DUF1854) - - - - - - - - - - - - DUF1854 k59_107495_1 1000565.METUNv1_02610 1.14e-42 156.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KU84@206389|Rhodocyclales 206389|Rhodocyclales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS,PAS_9,TarH k59_107495_2 1000565.METUNv1_02609 3.07e-58 184.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,2VR41@28216|Betaproteobacteria,2KW81@206389|Rhodocyclales 206389|Rhodocyclales NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_428985_1 1000565.METUNv1_02385 1.23e-14 72.4 2AMN7@1|root,31CIB@2|Bacteria,1P1XC@1224|Proteobacteria,2W4KR@28216|Betaproteobacteria,2KZ5F@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_429811_1 358220.C380_03430 3.94e-62 208.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,4AAVU@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_786541_2 661478.OP10G_1229 5.59e-48 160.0 COG0708@1|root,COG0708@2|Bacteria 2|Bacteria L double-stranded DNA 3'-5' exodeoxyribonuclease activity xth GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_893465_1 977880.RALTA_A1036 3.5e-42 145.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1K15D@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_893465_2 1123296.JQKE01000014_gene1901 8.94e-87 256.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,2KQGT@206351|Neisseriales 206351|Neisseriales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_501286_1 472759.Nhal_0398 1.11e-57 195.0 COG1670@1|root,COG3980@1|root,COG1670@2|Bacteria,COG3980@2|Bacteria,1Q330@1224|Proteobacteria,1RYTC@1236|Gammaproteobacteria,1WYUY@135613|Chromatiales 135613|Chromatiales M Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_501286_2 243231.GSU1972 1.33e-43 152.0 COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,42QBP@68525|delta/epsilon subdivisions,2WRDP@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Cytidylyltransferase - - 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 - R01117,R04215 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3 k59_644059_1 1000565.METUNv1_03305 2.22e-38 138.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,2KUUJ@206389|Rhodocyclales 206389|Rhodocyclales H Aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_644059_2 1000565.METUNv1_03304 2.31e-104 306.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2VSR5@28216|Betaproteobacteria,2KW2I@206389|Rhodocyclales 206389|Rhodocyclales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_644059_3 1000565.METUNv1_03303 2.81e-38 135.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,2KVE8@206389|Rhodocyclales 206389|Rhodocyclales H Phosphomethylpyrimidine kinase - - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_286772_2 1000565.METUNv1_00867 2.97e-38 142.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUQZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_857454_1 1000565.METUNv1_00403 1.44e-209 589.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,2KUBM@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_715165_1 748247.AZKH_0332 3.38e-48 165.0 2CJJV@1|root,30VBX@2|Bacteria,1RGSF@1224|Proteobacteria,2VS5D@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_179971_1 557598.LHK_00760 1.42e-60 191.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VK49@28216|Betaproteobacteria,2KRPJ@206351|Neisseriales 206351|Neisseriales S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_179971_2 1000565.METUNv1_00856 2.43e-62 193.0 2C19B@1|root,3392G@2|Bacteria,1N9ET@1224|Proteobacteria,2VWXP@28216|Betaproteobacteria,2KXCJ@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_644072_1 614083.AWQR01000029_gene2171 1.26e-89 275.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,4AAIA@80864|Comamonadaceae 28216|Betaproteobacteria CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 ubiF - - - - - - - - - - - FAD_binding_3,SE k59_286776_2 929556.Solca_4297 1.55e-30 113.0 28NIX@1|root,2ZBK6@2|Bacteria,4NMEI@976|Bacteroidetes,1IS0K@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2480) - - - - - - - - - - - - DUF2480 k59_679071_1 358220.C380_13780 1.89e-52 177.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,4AAHX@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_679071_2 1276756.AUEX01000037_gene272 1.74e-39 134.0 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2VUB7@28216|Betaproteobacteria,4AF35@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ArsC family yffB - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1072418_1 1000565.METUNv1_03414 2.64e-94 283.0 COG4221@1|root,COG4221@2|Bacteria,1QVTE@1224|Proteobacteria,2WGU3@28216|Betaproteobacteria,2KWAD@206389|Rhodocyclales 206389|Rhodocyclales S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_251026_2 1122951.ATUE01000008_gene102 6.37e-36 122.0 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,3NPEH@468|Moraxellaceae 1236|Gammaproteobacteria S Fe-S assembly protein IscX iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_251026_3 1279017.AQYJ01000023_gene3133 1.19e-22 89.4 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,4674E@72275|Alteromonadaceae 1236|Gammaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_36869_1 296591.Bpro_3536 1.07e-60 194.0 COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2VM30@28216|Betaproteobacteria,4AA37@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_821998_1 1000565.METUNv1_04001 5.46e-70 214.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,2KW5B@206389|Rhodocyclales 206389|Rhodocyclales S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1107509_1 1000565.METUNv1_01607 2.85e-139 398.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,2VKI3@28216|Betaproteobacteria,2KW0E@206389|Rhodocyclales 206389|Rhodocyclales G Haloacid dehalogenase-like hydrolase - - - ko:K02566 - - - - ko00000 - - - Hydrolase_6,Hydrolase_like k59_1107509_2 1000565.METUNv1_01606 6.16e-128 366.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,2KW43@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_465198_1 511.JT27_05725 1.54e-42 154.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,3T1ZH@506|Alcaligenaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_786565_1 1000565.METUNv1_02968 4.82e-74 240.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,2KUGX@206389|Rhodocyclales 206389|Rhodocyclales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1239_1 1198452.Jab_2c17460 2.87e-53 173.0 COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria 28216|Betaproteobacteria K Pfam Response regulator receiver ompR2 - - - - - - - - - - - Response_reg,Trans_reg_C k59_1239_2 1198452.Jab_2c17470 2.68e-33 126.0 COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,2VI30@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1072432_1 640081.Dsui_2420 1.12e-98 308.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,2KV3Z@206389|Rhodocyclales 206389|Rhodocyclales C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_571928_1 1000565.METUNv1_00480 1.47e-246 709.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_1036261_1 1112217.PPL19_03070 3.48e-83 262.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_36880_1 614083.AWQR01000009_gene707 1.21e-93 305.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,4ABZ1@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_715191_1 1122931.AUAE01000005_gene3275 1.08e-08 58.5 COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,2FPNU@200643|Bacteroidia 976|Bacteroidetes L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_715191_2 1217705.F900_00002 3.33e-21 85.9 2BTV0@1|root,32P2Q@2|Bacteria,1Q8QF@1224|Proteobacteria,1RTBA@1236|Gammaproteobacteria,3NSHE@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_429850_1 748247.AZKH_4419 3.09e-141 415.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,2KUAB@206389|Rhodocyclales 206389|Rhodocyclales O Mg chelatase subunit ChlI - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_679092_1 1211817.CCAT010000062_gene4062 1.6e-15 82.8 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,sCache_2 k59_1072447_1 1000565.METUNv1_01518 7.8e-158 451.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VN1Z@28216|Betaproteobacteria,2KXKA@206389|Rhodocyclales 206389|Rhodocyclales S COG0491 Zn-dependent hydrolases, including glyoxylases - - - ko:K01138 - - - - ko00000,ko01000 - - - Lactamase_B k59_1072447_2 1000565.METUNv1_01519 9.54e-89 266.0 COG5501@1|root,COG5501@2|Bacteria,1RBHP@1224|Proteobacteria,2VR7Y@28216|Betaproteobacteria,2KXWK@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ - - - - - - - - - - - - SoxY,SoxZ k59_322861_1 987059.RBXJA2T_16297 2.98e-30 124.0 COG4585@1|root,COG4585@2|Bacteria,1R1TC@1224|Proteobacteria,2VHUA@28216|Betaproteobacteria,1KIW1@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - 7TMR-DISM_7TM,HATPase_c,HisKA_3 k59_180011_1 1000565.METUNv1_04045 1.77e-83 281.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_715203_2 83219.PM02_07215 5.29e-24 93.2 2BW28@1|root,33184@2|Bacteria,1N7HM@1224|Proteobacteria,2UFE9@28211|Alphaproteobacteria,3ZY07@60136|Sulfitobacter 28211|Alphaproteobacteria S Protein of unknown function (DUF2798) - - - - - - - - - - - - DUF2798 k59_715203_3 264198.Reut_A2904 3e-103 301.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VK49@28216|Betaproteobacteria,1K090@119060|Burkholderiaceae 28216|Betaproteobacteria S flavodoxin nitric oxide synthase wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_215125_1 883126.HMPREF9710_04852 4.08e-105 332.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,473NR@75682|Oxalobacteraceae 28216|Betaproteobacteria P AcrB/AcrD/AcrF family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_893519_1 1000565.METUNv1_02453 1.36e-49 165.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_893519_2 395493.BegalDRAFT_2158 1.78e-09 60.5 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,4625A@72273|Thiotrichales 72273|Thiotrichales T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - CHASE2,Guanylate_cyc k59_1000503_1 1000565.METUNv1_00067 1.11e-127 372.0 COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VPAG@28216|Betaproteobacteria,2KW5W@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1000503_2 1000565.METUNv1_00068 1.75e-102 299.0 2BVVW@1|root,32175@2|Bacteria,1QZ0X@1224|Proteobacteria,2VSMJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Cytochrome P460 - - - - - - - - - - - - Cytochrome_P460 k59_501376_1 543728.Vapar_5170 4.11e-84 251.0 COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,4ABM5@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM YaeQ family protein yaeQ - - - - - - - - - - - YaeQ k59_429885_1 1005048.CFU_1946 7.99e-69 221.0 COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2VP98@28216|Betaproteobacteria,473TB@75682|Oxalobacteraceae 28216|Betaproteobacteria S Winged helix DNA-binding domain ycaQ - - ko:K09927 - - - - ko00000 - - - HTH_42 k59_465238_1 159087.Daro_3954 4.74e-51 182.0 COG2199@1|root,COG2703@1|root,COG5000@1|root,COG2199@2|Bacteria,COG2703@2|Bacteria,COG5000@2|Bacteria,1RGCV@1224|Proteobacteria,2VQEF@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_4,dCache_1 k59_1263_1 1000565.METUNv1_00122 3.4e-125 363.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,2KVEN@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1263_2 1000565.METUNv1_00123 7.35e-70 220.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KVK1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_501381_1 1346791.M529_09255 1.05e-06 51.6 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2TSS0@28211|Alphaproteobacteria,2K2QQ@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k59_501381_2 397945.Aave_2219 3.12e-36 133.0 COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2VQAZ@28216|Betaproteobacteria,4ADJV@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Surfeit locus 1 family protein - - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_251091_1 1121920.AUAU01000010_gene126 6.99e-18 81.6 28PU4@1|root,2ZCF6@2|Bacteria 2|Bacteria - - nrfJ - - - - - - - - - - - - k59_251091_2 443144.GM21_1075 3.11e-09 60.5 COG2204@1|root,COG3452@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3452@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_822050_1 1349767.GJA_4546 1.94e-79 238.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2VR4K@28216|Betaproteobacteria,4742H@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the glutathione peroxidase family bsaA - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_536361_1 1000565.METUNv1_02759 8.33e-143 422.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_465251_2 1000565.METUNv1_00422 1.17e-95 285.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,2VS39@28216|Betaproteobacteria,2KVKH@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_251107_1 1121035.AUCH01000008_gene1103 8.57e-101 306.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_964704_1 314231.FP2506_17299 1.24e-19 86.3 COG0388@1|root,COG0388@2|Bacteria,1MY3W@1224|Proteobacteria,2TTKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide amiE - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_964704_2 1096546.WYO_0903 1.14e-82 256.0 COG2207@1|root,COG2207@2|Bacteria,1P1FH@1224|Proteobacteria,2TRGB@28211|Alphaproteobacteria,1JQVW@119045|Methylobacteriaceae 28211|Alphaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type MA20_01125 - - - - - - - - - - - AraC_binding,HTH_18 k59_964704_3 1510531.JQJJ01000016_gene3210 5.9e-11 62.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,3JU19@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_01130 - - - - - - - - - - - MFS_1 k59_607533_2 1000565.METUNv1_02335 5.3e-166 478.0 COG0714@1|root,COG0714@2|Bacteria,1PM35@1224|Proteobacteria,2VM64@28216|Betaproteobacteria,2KW19@206389|Rhodocyclales 206389|Rhodocyclales O AAA domain (dynein-related subfamily) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5 k59_36942_1 663610.JQKO01000002_gene1194 3.27e-28 112.0 COG1251@1|root,COG2710@1|root,COG1251@2|Bacteria,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,2TQUV@28211|Alphaproteobacteria,3NAEU@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifE - - ko:K02587 - - - - ko00000 - - - Fer2_BFD,Oxidored_nitro k59_36942_2 269482.Bcep1808_6021 5.02e-56 187.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,1K457@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the NifD NifK NifE NifN family nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_108134_1 1000565.METUNv1_00786 1.95e-129 396.0 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,2KWN3@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_972069_2 1000565.METUNv1_00677 2.02e-110 335.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales 206389|Rhodocyclales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_613534_1 1000565.METUNv1_00769 1.64e-150 427.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,2KV2Q@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_368146_1 393480.FNP_1117 8.4e-09 55.8 COG1898@1|root,COG1898@2|Bacteria,379FK@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_368146_2 1260356.D920_01321 9.03e-59 191.0 COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli,4B0GS@81852|Enterococcaceae 91061|Bacilli H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_444630_1 314278.NB231_08788 1.25e-59 187.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,1X0VQ@135613|Chromatiales 135613|Chromatiales S PFAM conserved - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_444630_2 1112209.AHVZ01000004_gene1681 5.36e-11 61.6 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,3NJ39@468|Moraxellaceae 1236|Gammaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_46212_1 159087.Daro_0045 3.29e-85 270.0 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,2KVDI@206389|Rhodocyclales 206389|Rhodocyclales S transport system, permease and ATPase - - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2,ABC_tran k59_444645_1 1123033.ARNF01000071_gene175 1.57e-33 129.0 COG1517@1|root,COG1517@2|Bacteria,1R886@1224|Proteobacteria,1SMC7@1236|Gammaproteobacteria,3NQTG@468|Moraxellaceae 1236|Gammaproteobacteria L CRISPR-associated (Cas) DxTHG family - - - - - - - - - - - - Cas_DxTHG k59_116435_1 1000565.METUNv1_02003 0.000194 46.2 COG3211@1|root,COG3211@2|Bacteria,1R690@1224|Proteobacteria,2VMQX@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,VPEP k59_116435_2 1000565.METUNv1_03197 1.56e-40 137.0 2E7B6@1|root,331UK@2|Bacteria,1N80C@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_81528_1 1267211.KI669560_gene1066 2.94e-104 316.0 COG1395@1|root,COG1395@2|Bacteria,4P0EC@976|Bacteroidetes,1IVGE@117747|Sphingobacteriia 976|Bacteroidetes K SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_194267_1 1000565.METUNv1_03763 2.99e-22 95.5 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,2KVNW@206389|Rhodocyclales 206389|Rhodocyclales H Capsular polysaccharide biosynthesis protein CapK - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_194267_2 1000565.METUNv1_03764 1.59e-36 135.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,2KVCF@206389|Rhodocyclales 206389|Rhodocyclales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_903402_1 614083.AWQR01000018_gene1756 1.4e-111 325.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,4AA2U@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM methionine aminopeptidase, type I map GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_723423_1 452637.Oter_0423 5.01e-32 124.0 COG1536@1|root,COG1536@2|Bacteria,46US0@74201|Verrucomicrobia,3K7R6@414999|Opitutae 414999|Opitutae N FliG middle domain - - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_153569_2 760192.Halhy_4832 1.15e-19 85.5 COG0084@1|root,COG0084@2|Bacteria,4NEVW@976|Bacteroidetes,1INMV@117747|Sphingobacteriia 976|Bacteroidetes L TIGRFAM hydrolase, TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_475373_1 1198452.Jab_1c05580 6.56e-49 177.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,472D2@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Bacterial type II/III secretion system short domain gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_545273_1 187303.BN69_0171 6.72e-39 133.0 COG1670@1|root,COG1670@2|Bacteria,1RB2Q@1224|Proteobacteria,2U68H@28211|Alphaproteobacteria,36Z9Z@31993|Methylocystaceae 28211|Alphaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_153579_1 395495.Lcho_3314 3.32e-114 347.0 COG0524@1|root,COG3892@1|root,COG0524@2|Bacteria,COG3892@2|Bacteria,1MV6I@1224|Proteobacteria,2VMV5@28216|Betaproteobacteria,1KMP6@119065|unclassified Burkholderiales 28216|Betaproteobacteria G pfkB family carbohydrate kinase iolC - 2.7.1.92 ko:K03338 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DUF2090,PfkB k59_153579_2 543728.Vapar_6259 8.55e-42 144.0 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1045667_2 1120944.JONS01000056_gene53 0.000102 47.8 COG2856@1|root,COG2856@2|Bacteria,2IR22@201174|Actinobacteria 201174|Actinobacteria E Zn peptidase - - - - - - - - - - - - Peptidase_M78 k59_369411_1 543728.Vapar_3443 5.44e-100 306.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,4AAW3@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_195848_1 640081.Dsui_1902 1.31e-81 257.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,2KUP1@206389|Rhodocyclales 206389|Rhodocyclales O Alkyl hydroperoxide reductase - - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_298315_1 1304883.KI912532_gene3065 6.05e-73 229.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,2KUAN@206389|Rhodocyclales 206389|Rhodocyclales P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit alcE - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_298315_2 62928.azo2752 2e-06 49.7 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,2KW2D@206389|Rhodocyclales 206389|Rhodocyclales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_10805_1 1201290.M902_1057 4.01e-59 199.0 COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_660697_1 1166018.FAES_3942 1.02e-07 58.2 2EV6Y@1|root,33NMQ@2|Bacteria,4NYUA@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_724511_1 1000565.METUNv1_03627 5.07e-163 460.0 COG2267@1|root,COG2267@2|Bacteria,1QVBZ@1224|Proteobacteria,2VNI1@28216|Betaproteobacteria,2KUFT@206389|Rhodocyclales 206389|Rhodocyclales I Alpha beta hydrolase - - 1.11.1.10 ko:K00433 - - - - ko00000,ko01000 - - - Abhydrolase_6 k59_724511_3 1000565.METUNv1_03630 6.36e-282 789.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K11912,ko:K12132 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - HAMP,Pkinase k59_724511_4 1000565.METUNv1_03632 9.93e-164 468.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KUAS@206389|Rhodocyclales 206389|Rhodocyclales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_614278_1 365046.Rta_21000 8.12e-27 107.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,4AAT0@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Type II secretion system protein E pilT2 - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_614278_2 204773.HEAR1324 4.43e-49 163.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2VHUX@28216|Betaproteobacteria,472DP@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_937297_1 1000565.METUNv1_00877 1.21e-102 309.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,2KVKS@206389|Rhodocyclales 206389|Rhodocyclales C D-amino acid dehydrogenase dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_660722_2 1111732.AZOD01000021_gene619 1.8e-36 133.0 COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,1RZ9Q@1236|Gammaproteobacteria,1X3I0@135614|Xanthomonadales 135614|Xanthomonadales S Peptidogalycan biosysnthesis/recognition - - - - - - - - - - - - Acetyltransf_6,FemAB_like k59_797525_1 1000565.METUNv1_00134 1.1e-124 364.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,2KVWG@206389|Rhodocyclales 206389|Rhodocyclales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_973007_1 34506.g2403 1.07e-52 187.0 COG1004@1|root,COG1088@1|root,KOG0747@2759|Eukaryota,KOG2666@2759|Eukaryota,39ADA@33154|Opisthokonta,3BF2W@33208|Metazoa,3CWS2@33213|Bilateria,40FTF@6231|Nematoda,1KYEF@119089|Chromadorea,40UIK@6236|Rhabditida 33208|Metazoa G Male sterility protein - - - - - - - - - - - - Epimerase_2,GDP_Man_Dehyd,UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_338472_1 296591.Bpro_4583 1.07e-131 384.0 COG0189@1|root,COG0189@2|Bacteria,1QVU3@1224|Proteobacteria,2WH5E@28216|Betaproteobacteria,4AAK1@80864|Comamonadaceae 28216|Betaproteobacteria HJ glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_660745_1 1005048.CFU_1204 2.07e-86 262.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2VH0I@28216|Betaproteobacteria,476X1@75682|Oxalobacteraceae 28216|Betaproteobacteria G Permease component of ABC-type sugar transporter ugpA - - ko:K05814 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_338483_1 1038859.AXAU01000036_gene4913 8.21e-39 148.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,3JRFR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V ABC transporter - - - ko:K06147,ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.109.1,3.A.1.109.2,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_580078_1 1550073.JROH01000044_gene3144 4.32e-08 52.8 2A1RN@1|root,30Q08@2|Bacteria,1Q4TQ@1224|Proteobacteria,2UXZ7@28211|Alphaproteobacteria,2KBQ3@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1902) - - - - - - - - - - - - DUF1902 k59_153658_1 522306.CAP2UW1_2376 3.05e-61 199.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,1KQX2@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_724577_1 1121033.AUCF01000032_gene2626 1.4e-73 226.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2JRXM@204441|Rhodospirillales 204441|Rhodospirillales T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_724577_2 1121033.AUCF01000032_gene2625 1.08e-14 69.7 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,2JYX7@204441|Rhodospirillales 204441|Rhodospirillales T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_195965_2 1000565.METUNv1_02460 2.19e-84 251.0 COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,2KWCC@206389|Rhodocyclales 206389|Rhodocyclales T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_545369_1 365046.Rta_15460 1.47e-129 378.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VHD6@28216|Betaproteobacteria,4ACWE@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_867181_1 765911.Thivi_1206 5.42e-75 261.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2T5@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_724584_1 305700.B447_12187 2.9e-78 249.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VICV@28216|Betaproteobacteria,2KUY2@206389|Rhodocyclales 206389|Rhodocyclales L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_797572_1 1000565.METUNv1_01494 9.63e-79 238.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2VR6A@28216|Betaproteobacteria,2KWI6@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_797572_2 1000565.METUNv1_01493 2.81e-310 860.0 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,2WGPI@28216|Betaproteobacteria,2KX4H@206389|Rhodocyclales 206389|Rhodocyclales T LapD/MoxY periplasmic domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_758812_1 946483.Cenrod_0807 3.57e-52 172.0 COG1337@1|root,COG1337@2|Bacteria,1RBCM@1224|Proteobacteria,2VRVV@28216|Betaproteobacteria 28216|Betaproteobacteria L RAMP superfamily - - - ko:K09002 - - - - ko00000,ko02048 - - - RAMPs k59_222283_1 614083.AWQR01000058_gene1507 5.05e-90 293.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,4A9NT@80864|Comamonadaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_475477_1 614083.AWQR01000016_gene3591 1.51e-26 105.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,4AB76@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_475477_2 614083.AWQR01000016_gene3592 2.04e-31 112.0 COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,4AFD9@80864|Comamonadaceae 28216|Betaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_47283_1 1384054.N790_11960 6.42e-176 516.0 COG0657@1|root,COG2072@1|root,COG0657@2|Bacteria,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria,1X6KD@135614|Xanthomonadales 135614|Xanthomonadales IP Flavin-binding monooxygenase-like - - - - - - - - - - - - Abhydrolase_3,FMO-like,Pyr_redox_3 k59_403833_1 1000565.METUNv1_03298 4.09e-51 180.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_298411_1 1000565.METUNv1_02746 5.42e-120 366.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KUJG@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_195996_1 393595.ABO_0335 2.15e-53 169.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1XJX4@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_195996_2 1215092.PA6_010_01300 1.83e-32 121.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1YDF1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144 Pantoate_ligase k59_298418_1 1122951.ATUE01000005_gene1907 3.84e-102 318.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,3NJZQ@468|Moraxellaceae 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_758827_1 543728.Vapar_0047 5.33e-22 90.5 COG1280@1|root,COG1280@2|Bacteria,1RA1G@1224|Proteobacteria,2VKHI@28216|Betaproteobacteria,4AAFJ@80864|Comamonadaceae 28216|Betaproteobacteria E Lysine exporter protein (Lyse ygga) - - - - - - - - - - - - LysE k59_580128_1 420662.Mpe_A2518 2.91e-48 163.0 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2VMVW@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_338593_1 13616.ENSMODP00000005255 1.93e-17 87.0 KOG0937@1|root,KOG0937@2759|Eukaryota,39056@33154|Opisthokonta,3BC04@33208|Metazoa,3CWDS@33213|Bilateria,485NG@7711|Chordata,4947R@7742|Vertebrata,3JE0D@40674|Mammalia,4K3Q4@9263|Metatheria 33208|Metazoa U Adaptor-related protein complex 4, mu 1 subunit AP4M1 GO:0000139,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005794,GO:0005802,GO:0006605,GO:0006622,GO:0006623,GO:0006810,GO:0006886,GO:0006892,GO:0006895,GO:0006896,GO:0007034,GO:0007041,GO:0008104,GO:0008150,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016192,GO:0016482,GO:0019904,GO:0030117,GO:0030119,GO:0030124,GO:0031090,GO:0031410,GO:0031904,GO:0031974,GO:0031982,GO:0031984,GO:0032588,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0048193,GO:0048475,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0061462,GO:0070013,GO:0070727,GO:0071702,GO:0071705,GO:0072594,GO:0072657,GO:0072665,GO:0072666,GO:0090160,GO:0097708,GO:0098588,GO:0098791,GO:0098796,GO:1903361,GO:1990778 - ko:K12402 ko04142,map04142 - - - ko00000,ko00001,ko04131 - - - Adap_comp_sub,Clat_adaptor_s k59_614352_1 338969.Rfer_3431 1.13e-92 288.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,4AA3W@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_937369_1 1123255.JHYS01000005_gene615 1.21e-10 58.9 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,2VSTN@28216|Betaproteobacteria,4ADZM@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_937369_2 535289.Dtpsy_2875 1.25e-23 91.7 2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria,2VVXF@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_937369_3 1276756.AUEX01000001_gene1150 3.17e-05 44.7 COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2VMQN@28216|Betaproteobacteria,4ADD5@80864|Comamonadaceae 28216|Betaproteobacteria S UPF0126 domain - - - - - - - - - - - - UPF0126 k59_196037_1 631362.Thi970DRAFT_03068 3.42e-120 360.0 COG0846@1|root,COG0846@2|Bacteria,1R5V1@1224|Proteobacteria,1RSJX@1236|Gammaproteobacteria 1236|Gammaproteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_298447_1 1201288.M900_2762 1.48e-95 305.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2MSP3@213481|Bdellovibrionales,2WKEN@28221|Deltaproteobacteria 213481|Bdellovibrionales EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_47328_1 1000565.METUNv1_03450 5.69e-79 249.0 COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,2KV8I@206389|Rhodocyclales 206389|Rhodocyclales CI Bifunctional enoyl-CoA hydratase phosphate acetyltransferase pta - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas,PTA_PTB k59_196056_1 1000565.METUNv1_00287 3.82e-89 267.0 COG2863@1|root,COG2863@2|Bacteria,1RGTS@1224|Proteobacteria,2VSFZ@28216|Betaproteobacteria,2KWUX@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_261831_1 1000565.METUNv1_02236 1.87e-34 127.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,2KVAT@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_261831_2 1000565.METUNv1_02234 1.48e-128 384.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria,2KW15@206389|Rhodocyclales 206389|Rhodocyclales M Sulfatase - - - - - - - - - - - - Sulfatase k59_660906_1 1000565.METUNv1_02210 3.87e-05 44.7 COG3145@1|root,COG3145@2|Bacteria,1N5HB@1224|Proteobacteria,2VHNU@28216|Betaproteobacteria,2KWBE@206389|Rhodocyclales 206389|Rhodocyclales L 2OG-Fe(II) oxygenase superfamily alkB - 1.14.11.33 ko:K03919 - - - - ko00000,ko01000,ko03400 - - - 2OG-FeII_Oxy_2 k59_724654_1 1283284.AZUK01000001_gene164 3.55e-108 340.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Y5HR@135624|Aeromonadales 135624|Aeromonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_3,PAS_4 k59_10957_1 1173022.Cri9333_3711 3.79e-51 177.0 COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M6@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_4 k59_47342_1 1122951.ATUE01000006_gene869 1.87e-151 435.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,3NJCE@468|Moraxellaceae 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_278297_1 261292.Nit79A3_2572 2.62e-17 82.8 COG2067@1|root,COG4313@1|root,COG2067@2|Bacteria,COG4313@2|Bacteria,1MXNW@1224|Proteobacteria,2WGBD@28216|Betaproteobacteria,373UE@32003|Nitrosomonadales 28216|Betaproteobacteria C Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_417366_2 1538295.JY96_15135 7.7e-31 119.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VIY2@28216|Betaproteobacteria,1KPIM@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Glycosyltransferase like family 2 gtrB - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_917813_1 929562.Emtol_3709 6.43e-108 320.0 COG1284@1|root,COG1284@2|Bacteria,4NG9F@976|Bacteroidetes,47JNV@768503|Cytophagia 976|Bacteroidetes S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - DUF2179,YitT_membrane k59_739051_1 1276756.AUEX01000014_gene2879 1.18e-33 116.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,4AF2T@80864|Comamonadaceae 28216|Betaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_563215_1 1123354.AUDR01000018_gene1202 8.21e-05 43.9 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,1KRQF@119069|Hydrogenophilales 119069|Hydrogenophilales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_1027307_1 1144342.PMI40_02096 4.42e-39 147.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHPI@28216|Betaproteobacteria,475S0@75682|Oxalobacteraceae 28216|Betaproteobacteria T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - EAL,GGDEF,HAMP,dCache_3 k59_317555_1 29581.BW37_02166 2.01e-92 273.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,472VC@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_884510_1 342113.DM82_2068 1.46e-12 67.4 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,1K0M3@119060|Burkholderiaceae 28216|Betaproteobacteria OU peptidase, S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_771999_1 1137799.GZ78_22715 7.8e-36 130.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1XHPH@135619|Oceanospirillales 135619|Oceanospirillales P Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system znuC - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_771999_2 1122951.ATUE01000005_gene1882 6.61e-59 186.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,3NJTB@468|Moraxellaceae 1236|Gammaproteobacteria P Belongs to the Fur family zur - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_812616_1 1123508.JH636452_gene7001 8.51e-64 219.0 COG2010@1|root,COG2010@2|Bacteria,2IXJ6@203682|Planctomycetes 203682|Planctomycetes C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_917848_1 1396141.BATP01000027_gene1087 5.99e-14 79.3 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - - - - - - - - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_26272_1 1336245.JAGO01000010_gene606 5.01e-96 282.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1XI80@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_26272_2 425104.Ssed_2652 1.56e-15 76.3 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,2Q9GA@267890|Shewanellaceae 1236|Gammaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_703222_1 614083.AWQR01000010_gene1575 1.06e-129 372.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,4A9ZT@80864|Comamonadaceae 28216|Betaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_317597_1 1267211.KI669560_gene1024 1.18e-108 343.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1IWKA@117747|Sphingobacteriia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - FG-GAP,UnbV_ASPIC,VCBS k59_1027367_1 1123504.JQKD01000013_gene1021 8.92e-80 241.0 COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,2VQI0@28216|Betaproteobacteria,4AE5G@80864|Comamonadaceae 28216|Betaproteobacteria L TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit paaD - - ko:K02612 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001 - - - FeS_assembly_P k59_169664_1 272557.APE_0427.1 2.8e-10 68.9 COG1573@1|root,arCOG00905@2157|Archaea,2XQ7T@28889|Crenarchaeota 28889|Crenarchaeota L TIGRFAM phage SPO1 DNA polymerase-related protein - GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_169664_2 1117958.PE143B_0130750 1.24e-52 176.0 COG0847@1|root,COG0847@2|Bacteria,1RBBK@1224|Proteobacteria,1S6T7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - - ko:K10857 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - DNA_pol_A_exo1,QSregVF_b,RNase_T k59_169664_3 479434.Sthe_2371 3.93e-10 68.9 COG2189@1|root,COG2189@2|Bacteria,2G5WR@200795|Chloroflexi 200795|Chloroflexi H PFAM DNA methylase N-4 N-6 domain protein - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1027368_1 443144.GM21_1010 4.94e-76 254.0 COG0553@1|root,COG1787@1|root,COG0553@2|Bacteria,COG1787@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions 1224|Proteobacteria KL helicase domain protein - - - - - - - - - - - - Helicase_C,Mrr_cat,SNF2_N k59_235509_1 1276756.AUEX01000015_gene1994 2.55e-100 311.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,4AA6N@80864|Comamonadaceae 28216|Betaproteobacteria I Methylmalonyl-CoA mutase large subunit icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_278371_1 1000565.METUNv1_01202 4.45e-77 256.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_26300_2 1288494.EBAPG3_15130 5.56e-41 151.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,2VJIH@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_317650_2 1121033.AUCF01000018_gene5815 1.18e-28 112.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2JQGM@204441|Rhodospirillales 204441|Rhodospirillales S Zn-dependent proteases and their inactivated homologs pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_493486_1 1122951.ATUE01000006_gene1367 2.32e-18 83.2 COG3147@1|root,COG3147@2|Bacteria 2|Bacteria S peptidoglycan binding dedD GO:0000910,GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0030428,GO:0032153,GO:0032506,GO:0042834,GO:0044464,GO:0051301,GO:0097367 - ko:K02453,ko:K03749 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - SPOR k59_493486_2 1380387.JADM01000021_gene1664 4.88e-18 79.7 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XKNI@135619|Oceanospirillales 135619|Oceanospirillales S colicin V production cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_1130658_1 309801.trd_A0155 7.04e-07 52.4 COG2197@1|root,COG3170@1|root,COG2197@2|Bacteria,COG3170@2|Bacteria,2G80G@200795|Chloroflexi,27XVP@189775|Thermomicrobia 189775|Thermomicrobia T Two component transcriptional regulator, LuxR family - - - - - - - - - - - - Response_reg k59_1130658_2 640081.Dsui_0383 9.91e-38 132.0 2EDY7@1|root,337T3@2|Bacteria,1RKSZ@1224|Proteobacteria,2VTSJ@28216|Betaproteobacteria,2KWV4@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_389441_1 1122185.N792_02510 1.66e-06 55.8 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1X53G@135614|Xanthomonadales 135614|Xanthomonadales L Nucleotidyltransferase DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_703280_1 768671.ThimaDRAFT_1003 1.42e-28 115.0 COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,1S7SZ@1236|Gammaproteobacteria,1WY3Q@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_98563_1 1157708.KB907450_gene6173 1.31e-81 262.0 COG1511@1|root,COG1511@2|Bacteria,1R6MB@1224|Proteobacteria,2VKRK@28216|Betaproteobacteria,4AGFT@80864|Comamonadaceae 28216|Betaproteobacteria S domain protein - - - ko:K01421 - - - - ko00000 - - - ABC2_membrane_3 k59_1027429_1 1211115.ALIQ01000009_gene4289 3.59e-89 280.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2TR0H@28211|Alphaproteobacteria,3N9QT@45404|Beijerinckiaceae 28211|Alphaproteobacteria K GAF modulated sigma54 specific transcriptional regulator, Fis family acoR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activ_2,Sigma54_activat k59_849861_1 1000565.METUNv1_02628 2.14e-41 153.0 COG0835@1|root,COG0835@2|Bacteria,1RBIB@1224|Proteobacteria,2VR05@28216|Betaproteobacteria 28216|Betaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_278414_2 633131.TR2A62_3600 6.45e-15 70.1 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2UC5K@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_917918_1 887062.HGR_08964 6.99e-64 213.0 COG2199@1|root,COG3706@2|Bacteria,1QUY1@1224|Proteobacteria,2VM8G@28216|Betaproteobacteria,4ADSZ@80864|Comamonadaceae 28216|Betaproteobacteria T GGDEF domain - - - - - - - - - - - - GGDEF k59_133737_2 944435.AXAJ01000012_gene2873 7.77e-52 164.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,1K7QK@119060|Burkholderiaceae 28216|Betaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_772070_1 1123257.AUFV01000026_gene2 1.57e-74 238.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria,1X4PP@135614|Xanthomonadales 135614|Xanthomonadales P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like k59_133748_1 1227739.Hsw_3392 1.33e-26 113.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,47MEM@768503|Cytophagia 976|Bacteroidetes S Alpha-2-macroglobulin family - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2,Plug k59_849903_1 1538295.JY96_16010 2.49e-72 240.0 COG1593@1|root,COG1593@2|Bacteria 2|Bacteria G mannitol 2-dehydrogenase activity - - - - - - - - - - - - DctM k59_1098298_1 1000565.METUNv1_04044 4.69e-55 186.0 COG2831@1|root,COG2831@2|Bacteria,1PRBP@1224|Proteobacteria,2VHDS@28216|Betaproteobacteria 28216|Betaproteobacteria U hemolysin activation secretion protein fhaC5 - - - - - - - - - - - POTRA_2,ShlB k59_392160_1 614083.AWQR01000001_gene3049 1.02e-21 93.6 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4AC0U@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_392160_2 296591.Bpro_0603 6.78e-98 290.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJ0Q@28216|Betaproteobacteria,4A9RD@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_919563_1 903818.KI912268_gene2269 2.86e-116 335.0 COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria 57723|Acidobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_171749_1 399739.Pmen_4309 6.03e-12 72.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YEAZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_495852_1 614083.AWQR01000027_gene3780 7.48e-31 110.0 2E6W9@1|root,32SGN@2|Bacteria,1MZMD@1224|Proteobacteria,2VU0A@28216|Betaproteobacteria,4AEVU@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3567) - - - - - - - - - - - - DUF3567 k59_495852_2 358220.C380_21800 1.45e-49 160.0 COG1734@1|root,COG1734@2|Bacteria,1NA1P@1224|Proteobacteria,2VX46@28216|Betaproteobacteria,4AFF7@80864|Comamonadaceae 28216|Betaproteobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_704950_1 936053.I1BYH8 5.94e-34 134.0 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi,1GXN4@112252|Fungi incertae sedis 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_495860_1 76114.ebA4100 1.91e-104 318.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,2KV14@206389|Rhodocyclales 206389|Rhodocyclales M Membrane-bound lytic murein transglycosylase mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_1099467_1 614083.AWQR01000038_gene1361 9.54e-54 181.0 COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,2VISN@28216|Betaproteobacteria,4ADJS@80864|Comamonadaceae 28216|Betaproteobacteria L DNA alkylation repair - - - - - - - - - - - - DNA_alkylation,HEAT k59_1029501_1 1276756.AUEX01000011_gene1275 4.51e-111 345.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,4AA22@80864|Comamonadaceae 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_887580_1 755732.Fluta_0010 1.17e-22 102.0 COG0296@1|root,COG2957@1|root,COG0296@2|Bacteria,COG2957@2|Bacteria,4NJ5R@976|Bacteroidetes,1I7K9@117743|Flavobacteriia 976|Bacteroidetes E Peptidase family C25, C terminal ig-like domain - GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.22.37 ko:K08589 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_C25,Peptidase_C25_C,Propeptide_C25 k59_1029506_1 1348657.M622_01290 1.81e-45 149.0 COG2944@1|root,COG2944@2|Bacteria,1N05Y@1224|Proteobacteria,2VSDE@28216|Betaproteobacteria,2KXG3@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3 k59_1029506_2 1117958.PE143B_0101455 3.47e-06 49.7 COG1360@1|root,COG1360@2|Bacteria,1R3Q0@1224|Proteobacteria,1S1J2@1236|Gammaproteobacteria 1236|Gammaproteobacteria N Membrane MotB of proton-channel complex MotA/MotB - - - - - - - - - - - - MotB_plug,OmpA k59_887621_1 1173025.GEI7407_0339 1.6e-34 133.0 COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales 1117|Cyanobacteria M Tetratricopeptide repeat - - - - - - - - - - - - DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_887621_2 1207063.P24_17897 6.54e-10 60.1 COG0438@1|root,COG0438@2|Bacteria,1NJ19@1224|Proteobacteria,2TRT4@28211|Alphaproteobacteria,2JPS9@204441|Rhodospirillales 204441|Rhodospirillales M Gkycosyl transferase family 4 group expC - - - - - - - - - - - Glyco_trans_4_3,Glycos_transf_1 k59_419190_1 614083.AWQR01000005_gene1073 3.49e-243 673.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,4ABB3@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM glycine cleavage system T protein gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_919627_1 1168034.FH5T_06120 1.2e-23 106.0 COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,2FN8C@200643|Bacteroidia 976|Bacteroidetes O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_2 k59_1029562_1 877424.ATWC01000005_gene33 0.000116 49.7 COG0438@1|root,COG0438@2|Bacteria,1UBCE@1239|Firmicutes,24DYC@186801|Clostridia,27TCF@186928|unclassified Lachnospiraceae 186801|Clostridia M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_100669_2 247639.MGP2080_07579 7.76e-24 102.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J4N1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_1029584_1 85643.Tmz1t_1965 5.45e-43 157.0 COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,2VPEK@28216|Betaproteobacteria,2KVU4@206389|Rhodocyclales 206389|Rhodocyclales C e3 binding domain - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1132601_1 338969.Rfer_1680 1.48e-104 312.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4ABGS@80864|Comamonadaceae 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_887681_1 640081.Dsui_2411 4.6e-13 69.3 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,2KV0K@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids dadX - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_887681_2 1163617.SCD_n01590 6.15e-62 201.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria 28216|Betaproteobacteria EGP major facilitator superfamily lplT - - - - - - - - - - - MFS_1 k59_237167_1 1304883.KI912532_gene2807 7.31e-35 131.0 COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,2VJFD@28216|Betaproteobacteria,2KUYC@206389|Rhodocyclales 206389|Rhodocyclales P ferric reductase - - - - - - - - - - - - FAD_binding_8,Ferric_reduct,NAD_binding_1 k59_392295_1 1223521.BBJX01000008_gene1280 1.01e-136 406.0 COG0457@1|root,COG0745@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,1NNCT@1224|Proteobacteria,2VK0Z@28216|Betaproteobacteria,4ABC4@80864|Comamonadaceae 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_4,TPR_8 k59_237168_1 1095769.CAHF01000018_gene812 7.85e-106 315.0 COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,4764U@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC-type Fe3 transport system, periplasmic afuA - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_705057_1 981223.AIED01000087_gene2210 1.68e-31 117.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,3NJ8I@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 CDP-OH_P_transf k59_705057_2 1182590.BN5_01645 2.46e-35 134.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1YFMF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_100729_1 357804.Ping_0779 4.91e-11 68.2 COG0463@1|root,COG0463@2|Bacteria,1PFEW@1224|Proteobacteria,1RXGY@1236|Gammaproteobacteria,2QJ76@267894|Psychromonadaceae 1236|Gammaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_135512_1 1121035.AUCH01000016_gene2233 2.04e-39 148.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KVAE@206389|Rhodocyclales 206389|Rhodocyclales NT Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_990449_1 1185876.BN8_06684 1.17e-43 159.0 COG5297@1|root,COG5297@2|Bacteria,4NG19@976|Bacteroidetes,47KXX@768503|Cytophagia 976|Bacteroidetes G Protein of unknown function (DUF1593) - - - - - - - - - - - - DUF1593 k59_100745_1 1430440.MGMSRv2_0226 3.42e-31 125.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF k59_255767_1 398578.Daci_6011 1.16e-15 83.6 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2VJUS@28216|Betaproteobacteria,4ACPY@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1004936_1 62928.azo1428 2.28e-96 286.0 COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,2VH72@28216|Betaproteobacteria,2KVXH@206389|Rhodocyclales 206389|Rhodocyclales C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_507857_1 903818.KI912268_gene1101 1.75e-34 137.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_469625_1 748247.AZKH_1660 7.05e-99 306.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KUQJ@206389|Rhodocyclales 206389|Rhodocyclales P Transport of potassium into the cell - - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_469627_1 987059.RBXJA2T_14501 1.98e-37 131.0 COG3094@1|root,COG3094@2|Bacteria,1NPTP@1224|Proteobacteria,2VWBN@28216|Betaproteobacteria,1KMPT@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Invasion gene expression up-regulator, SirB - - - - - - - - - - - - SirB k59_650875_1 580332.Slit_1636 1.79e-11 62.0 COG5615@1|root,COG5615@2|Bacteria,1N3BK@1224|Proteobacteria,2VQHM@28216|Betaproteobacteria,44WI1@713636|Nitrosomonadales 28216|Betaproteobacteria S Copper resistance protein D - - - - - - - - - - - - CopD k59_650875_2 1288826.MSNKSG1_09783 2.88e-68 221.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPN9@1236|Gammaproteobacteria,464QS@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains ybiT GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0050896 - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_826625_1 1000565.METUNv1_01504 2.52e-57 182.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2VJVJ@28216|Betaproteobacteria,2KV35@206389|Rhodocyclales 206389|Rhodocyclales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_826625_2 62928.azo0958 8.31e-58 180.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2VSJ2@28216|Betaproteobacteria,2KWKM@206389|Rhodocyclales 206389|Rhodocyclales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_329230_1 296591.Bpro_2164 1.58e-129 380.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,4AAS7@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM carboxyl transferase pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1079207_1 194699.Q775D1_BPBPP 3.97e-124 373.0 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_255783_1 330214.NIDE0585 1.89e-24 107.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,3J0ZF@40117|Nitrospirae 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_1004962_1 1296415.JACC01000010_gene2147 3.8e-17 75.5 COG0236@1|root,COG0236@2|Bacteria,4P8UA@976|Bacteroidetes 976|Bacteroidetes IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_1110933_1 522306.CAP2UW1_4025 1.51e-119 350.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,1KPSS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_507887_1 1005048.CFU_3763 1.23e-56 185.0 COG0745@1|root,COG0745@2|Bacteria,1QUN8@1224|Proteobacteria,2VMWS@28216|Betaproteobacteria,4762H@75682|Oxalobacteraceae 28216|Betaproteobacteria K Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_791119_1 1163617.SCD_n02294 2.78e-74 237.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2VIT3@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - - - - - - - - - - HD,HD_5,Response_reg k59_76920_1 477228.YO5_09215 6.08e-58 186.0 COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,1S5AB@1236|Gammaproteobacteria,1Z05G@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_11 k59_76920_2 1000565.METUNv1_02779 1.85e-10 59.7 COG1846@1|root,COG1846@2|Bacteria,1N0TW@1224|Proteobacteria,2W2KE@28216|Betaproteobacteria 28216|Betaproteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - - k59_1110935_1 886293.Sinac_7123 1.32e-69 220.0 COG0412@1|root,COG0412@2|Bacteria,2IYMM@203682|Planctomycetes 203682|Planctomycetes Q COG0412 Dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_5158_1 159087.Daro_0244 3.27e-93 301.0 COG0642@1|root,COG0784@1|root,COG3829@1|root,COG4564@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4564@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - CHASE,DUF4118,GAF,GAF_2,HATPase_c,HisKA,Hpt,NMT1,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_1041135_1 925409.KI911562_gene2950 7.46e-44 149.0 COG0289@1|root,COG0289@2|Bacteria,4NDX2@976|Bacteroidetes,1IP8Q@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_1079243_1 1000565.METUNv1_03500 1.05e-138 400.0 COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2VQ2H@28216|Betaproteobacteria,2KWEQ@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1004984_1 614083.AWQR01000005_gene1118 5.13e-59 191.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,4AA8Q@80864|Comamonadaceae 28216|Betaproteobacteria T Signal transduction histidine kinase, nitrogen specific ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_861094_1 1000565.METUNv1_01627 4.43e-118 357.0 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,2KVDI@206389|Rhodocyclales 206389|Rhodocyclales S transport system, permease and ATPase - - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2,ABC_tran k59_861094_3 118173.KB235914_gene3700 3.71e-44 173.0 COG2199@1|root,COG3850@1|root,COG5002@1|root,COG3706@2|Bacteria,COG3850@2|Bacteria,COG5002@2|Bacteria,1GHEK@1117|Cyanobacteria,1HI37@1150|Oscillatoriales 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,Response_reg,dCache_1 k59_575465_1 296591.Bpro_2517 1.26e-38 131.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,2VT2B@28216|Betaproteobacteria,4AEEB@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Type IV pilus assembly PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_575465_2 535289.Dtpsy_1984 2.69e-51 169.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,4AAED@80864|Comamonadaceae 28216|Betaproteobacteria L TIGRFAM hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_898531_2 1046714.AMRX01000001_gene1805 1.16e-17 75.5 2DSH8@1|root,33G48@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_650943_1 1198452.Jab_2c12150 3.8e-87 266.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,47608@75682|Oxalobacteraceae 28216|Betaproteobacteria V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_1041154_1 929556.Solca_1812 1.32e-80 248.0 COG1052@1|root,COG1052@2|Bacteria,4PKE3@976|Bacteroidetes,1INZ9@117747|Sphingobacteriia 976|Bacteroidetes CH D-isomer specific 2-hydroxyacid dehydrogenase hprA - 1.1.1.29,1.1.1.399,1.1.1.95 ko:K00018,ko:K00058 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020,M00346 R00717,R01388,R01513 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_111964_1 700598.Niako_5299 3.91e-18 84.0 COG5434@1|root,COG5434@2|Bacteria,4NG4T@976|Bacteroidetes,1IPJZ@117747|Sphingobacteriia 976|Bacteroidetes G PFAM glycoside hydrolase family 28 - - - - - - - - - - - - Glyco_hydro_28,Lipase_GDSL_2,Pectate_lyase_3 k59_111964_2 1408813.AYMG01000001_gene3335 3.36e-50 177.0 COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,1IP2G@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_255823_1 265072.Mfla_2107 2.36e-71 224.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KKFY@206350|Nitrosomonadales 206350|Nitrosomonadales NU PFAM type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1041156_1 1122603.ATVI01000007_gene1487 1.34e-114 358.0 COG1002@1|root,COG1002@2|Bacteria,1MWRH@1224|Proteobacteria,1RRRA@1236|Gammaproteobacteria,1X5JC@135614|Xanthomonadales 135614|Xanthomonadales V Type II restriction enzyme, methylase - - - - - - - - - - - - - k59_76953_1 1000565.METUNv1_00136 1.87e-127 368.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,2KU92@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_791146_2 391036.EHF_0548 1.3e-47 164.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,47EYG@766|Rickettsiales 766|Rickettsiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_255832_2 1000565.METUNv1_03173 4.5e-155 441.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,2KUC9@206389|Rhodocyclales 206389|Rhodocyclales M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_932376_1 714943.Mucpa_7071 5.45e-76 252.0 COG0013@1|root,COG0013@2|Bacteria,4NFHW@976|Bacteroidetes,1INPU@117747|Sphingobacteriia 976|Bacteroidetes J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_41685_1 76114.ebA883 1.2e-86 267.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,2KVXA@206389|Rhodocyclales 206389|Rhodocyclales S cytochrome d1 heme nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_41685_2 748247.AZKH_3546 2.24e-34 121.0 COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2VTXS@28216|Betaproteobacteria,2KX2E@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K19344 - - - - ko00000 - - - Cytochrome_CBB3 k59_41685_3 983917.RGE_06590 3.94e-09 53.9 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1KNZU@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_507944_2 1000565.METUNv1_03768 1.57e-36 139.0 COG0367@1|root,COG0367@2|Bacteria,1R769@1224|Proteobacteria,2W1JM@28216|Betaproteobacteria 28216|Betaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_218072_1 1000565.METUNv1_00197 1.85e-122 370.0 COG4206@1|root,COG4206@2|Bacteria,1QUPS@1224|Proteobacteria,2WH5H@28216|Betaproteobacteria 28216|Betaproteobacteria P TIGRFAM TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_218072_2 1000565.METUNv1_00198 1.19e-64 199.0 COG0784@1|root,COG0784@2|Bacteria,1QVYQ@1224|Proteobacteria,2WGV7@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_76970_1 1000565.METUNv1_02736 8.32e-12 64.3 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria,2KV82@206389|Rhodocyclales 206389|Rhodocyclales S Protein conserved in bacteria - - - - - - - - - - - - - k59_76970_2 1123256.KB907925_gene1511 1.77e-11 63.5 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1X61X@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1318) - - - - - - - - - - - - DUF1318 k59_76970_3 1000565.METUNv1_02738 9.52e-51 163.0 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,2VSM9@28216|Betaproteobacteria,2KWKK@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09978 - - - - ko00000 - - - DUF1318 k59_255835_1 59538.XP_005980843.1 1.91e-05 45.8 2EBQT@1|root,2SHRX@2759|Eukaryota,3AFSN@33154|Opisthokonta,3BX7A@33208|Metazoa,3DDGA@33213|Bilateria 33208|Metazoa S Type III flagellar switch regulator (C-ring) FliN C-term - - - - - - - - - - - - FliMN_C k59_255835_2 1121127.JAFA01000003_gene1978 2.44e-28 102.0 COG0401@1|root,COG0401@2|Bacteria,1N9JZ@1224|Proteobacteria,2VVTC@28216|Betaproteobacteria,1KA44@119060|Burkholderiaceae 28216|Betaproteobacteria S Proteolipid membrane potential modulator pilT - - - - - - - - - - - Pmp3 k59_1041169_1 1000565.METUNv1_03558 6.16e-236 683.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,2KUFA@206389|Rhodocyclales 206389|Rhodocyclales H methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1110961_1 243233.MCA0236 2.37e-73 223.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,1S5CH@1236|Gammaproteobacteria,1XFMS@135618|Methylococcales 135618|Methylococcales S Protein of unknown function, DUF269 - - - - - - - - - - - - DUF269 k59_1110961_2 987059.RBXJA2T_04373 5.66e-28 102.0 COG5420@1|root,COG5420@2|Bacteria,1N74Y@1224|Proteobacteria,2VVVF@28216|Betaproteobacteria,1KMK9@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Rop-like - - - - - - - - - - - - Rop-like k59_1110961_3 243233.MCA0238 2.12e-18 78.6 COG3383@1|root,COG3383@2|Bacteria,1QU53@1224|Proteobacteria 1224|Proteobacteria C Ferredoxin fdxB - - - - - - - - - - - Fer4,Fer4_10,Fer4_4,Fer4_7 k59_576334_2 323261.Noc_1989 1.55e-60 196.0 COG0110@1|root,COG0110@2|Bacteria,1RBYA@1224|Proteobacteria 1224|Proteobacteria S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep,Hexapep_2 k59_576334_3 29581.BW37_01449 9.29e-66 213.0 COG0778@1|root,COG0778@2|Bacteria,1PDX3@1224|Proteobacteria,2VNSD@28216|Betaproteobacteria,476Y6@75682|Oxalobacteraceae 28216|Betaproteobacteria C Nitroreductase family moeY - - - - - - - - - - - Nitroreductase k59_6197_1 1000565.METUNv1_00724 0.0 1100.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,2KUJR@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_969123_1 1000565.METUNv1_02045 3.71e-91 280.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales 206389|Rhodocyclales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_969123_2 1000565.METUNv1_02046 1.8e-27 110.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,2KVMW@206389|Rhodocyclales 206389|Rhodocyclales K RNB - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_293198_1 358220.C380_11390 1.24e-173 502.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,4AAI1@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM peptidase M3A and M3B, thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_652820_1 381666.H16_A3359 2.99e-109 328.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2VH7E@28216|Betaproteobacteria,1JZT9@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_509762_1 1304883.KI912532_gene2098 4.73e-13 70.1 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria,2KUTQ@206389|Rhodocyclales 206389|Rhodocyclales P Periplasmic copper-binding protein (NosD) - - - ko:K07218 - - - - ko00000 - - - NosD k59_509762_2 1304883.KI912532_gene2099 1.04e-62 201.0 2DBUZ@1|root,2ZB8W@2|Bacteria,1QWGF@1224|Proteobacteria,2VM8U@28216|Betaproteobacteria,2KVDM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_256957_2 1123290.AUDQ01000004_gene329 6.88e-22 92.8 COG2197@1|root,COG2197@2|Bacteria,1TVTF@1239|Firmicutes,4HAJW@91061|Bacilli,26E2J@186818|Planococcaceae 91061|Bacilli T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain desR - - ko:K07693 ko02020,map02020 M00479 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_862154_1 290400.Jann_1938 4.52e-34 127.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria 28211|Alphaproteobacteria M membrane - - - - - - - - - - - - VIT1 k59_256958_2 1458427.BAWN01000009_gene629 8.92e-24 101.0 COG2207@1|root,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2VKP6@28216|Betaproteobacteria,4AE1J@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, arabinose operon control protein - - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_112947_1 1123487.KB892865_gene1523 5.62e-44 149.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,2VJ7M@28216|Betaproteobacteria,2KVHC@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_112947_2 243233.MCA2820 1.16e-52 176.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1XF7N@135618|Methylococcales 135618|Methylococcales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_112947_3 1123487.KB892865_gene1525 7.46e-44 154.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2VKUY@28216|Betaproteobacteria,2KVVJ@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_438550_1 1276756.AUEX01000010_gene1663 9.19e-103 321.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2VHT2@28216|Betaproteobacteria,4A9NW@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_792308_1 402626.Rpic_2329 1.79e-27 105.0 2C5GJ@1|root,2ZEJ3@2|Bacteria,1P90B@1224|Proteobacteria,2W5VA@28216|Betaproteobacteria,1KES7@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_792308_2 321846.PS417_24850 6.14e-16 81.6 COG2932@1|root,COG2932@2|Bacteria,1PIRG@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator prtR_2 - - - - - - - - - - - HTH_3,Peptidase_S24 k59_438556_1 1000565.METUNv1_01315 2.41e-136 392.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,2KYRE@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_293235_1 1121920.AUAU01000019_gene2573 4.64e-67 213.0 2DBM2@1|root,2Z9WS@2|Bacteria 2|Bacteria S Domain of unknown function (DUF1839) - - - - - - - - - - - - DUF1839 k59_933326_1 153721.MYP_4507 1.66e-59 208.0 COG2373@1|root,COG2373@2|Bacteria,4NG2S@976|Bacteroidetes,47K94@768503|Cytophagia 976|Bacteroidetes P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - A2M,A2M_N,A2M_comp,A2M_recep,CarbopepD_reg_2,Plug,Thiol-ester_cl k59_256971_1 365044.Pnap_1627 1.31e-132 395.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,4ABCV@80864|Comamonadaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_42741_1 279714.FuraDRAFT_1306 1.16e-61 200.0 COG0583@1|root,COG0583@2|Bacteria,1NQGZ@1224|Proteobacteria,2VZWX@28216|Betaproteobacteria,2KSKU@206351|Neisseriales 206351|Neisseriales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_792318_2 614083.AWQR01000019_gene3796 1.63e-145 415.0 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,4ABW3@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_57238_1 1406840.Q763_05985 3.36e-09 60.1 COG4886@1|root,COG4935@1|root,COG4886@2|Bacteria,COG4935@2|Bacteria,4NFXV@976|Bacteroidetes,1I00F@117743|Flavobacteriia,2NUTP@237|Flavobacterium 976|Bacteroidetes O Pkd domain containing protein - - - - - - - - - - - - VCBS k59_462154_1 1100720.ALKN01000045_gene261 3.25e-62 214.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,4AC02@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - - - - - - - - - - ACR_tran k59_462164_1 1206101.AZXC01000012_gene1243 8.45e-13 70.1 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_310516_1 1198452.Jab_2c14430 4.46e-33 123.0 COG0457@1|root,COG0457@2|Bacteria,1REPB@1224|Proteobacteria,2VSE1@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_127710_1 1118058.CAGY01000005_gene1144 1.13e-18 85.9 COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4D3GB@85005|Actinomycetales 201174|Actinobacteria P ABC transporter permease - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_127710_2 1236973.JCM9157_2475 2.82e-18 85.5 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,4HA5R@91061|Bacilli,1ZBRR@1386|Bacillus 91061|Bacilli G Alpha-galactosidase galA - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase k59_355056_1 1198452.Jab_1c20910 1.86e-74 229.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,4730Z@75682|Oxalobacteraceae 28216|Betaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri,YfiO k59_843207_1 1000565.METUNv1_02670 7.72e-126 371.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KUPY@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_20956_1 1121035.AUCH01000008_gene1083 9.48e-108 320.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,2KUN7@206389|Rhodocyclales 206389|Rhodocyclales S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_533830_1 983917.RGE_16920 7.32e-28 108.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,1KKEX@119065|unclassified Burkholderiales 28216|Betaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_676998_1 296591.Bpro_0160 2.3e-116 349.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,4AB7Z@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1061035_2 452662.SJA_C1-09960 1.19e-37 142.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT50@1224|Proteobacteria,2TTND@28211|Alphaproteobacteria 28211|Alphaproteobacteria L AAA domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2,Toprim_4 k59_677007_1 864051.BurJ1DRAFT_0288 1.06e-92 285.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1KJ18@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_230891_1 614083.AWQR01000044_gene2032 5.13e-86 265.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AAD0@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_621944_1 343509.SG1194 1.51e-19 98.2 2CAR4@1|root,331W1@2|Bacteria,1ND9P@1224|Proteobacteria,1SETE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_272579_1 1000565.METUNv1_00538 1.66e-67 226.0 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,2VN8K@28216|Betaproteobacteria,2KXMM@206389|Rhodocyclales 206389|Rhodocyclales S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_533884_1 1000565.METUNv1_02795 4.7e-114 349.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,2KVAJ@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_355123_1 365044.Pnap_1570 9.6e-34 131.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2WHK4@28216|Betaproteobacteria 28216|Betaproteobacteria KT Nif-specific regulatory protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_355123_2 546264.NEIFLAOT_01548 1.12e-06 50.1 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,2KPHF@206351|Neisseriales 206351|Neisseriales H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_677068_1 1349822.NSB1T_00340 1.42e-07 52.4 COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,2FRDY@200643|Bacteroidia,22WAU@171551|Porphyromonadaceae 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family rfbH - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_533914_1 1000565.METUNv1_03053 5.09e-198 559.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,2KUA4@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DNA photolyase family phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_621965_1 1250006.JHZZ01000001_gene153 5.27e-82 255.0 COG0327@1|root,COG0327@2|Bacteria,4NF51@976|Bacteroidetes,1HXRQ@117743|Flavobacteriia,3VW91@52959|Polaribacter 976|Bacteroidetes S Belongs to the GTP cyclohydrolase I type 2 NIF3 family yqfO - - - - - - - - - - - NIF3 k59_57316_1 709986.Deima_2953 2.88e-14 79.7 COG1361@1|root,COG2373@1|root,COG3386@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF11,SdrD_B k59_57317_1 1095769.CAHF01000013_gene3353 3.45e-25 100.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,472PK@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_57317_2 864073.HFRIS_003238 2.64e-67 220.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,47321@75682|Oxalobacteraceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_1094760_1 1249627.D779_1983 9.9e-62 210.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,1T1NS@1236|Gammaproteobacteria,1WZRX@135613|Chromatiales 135613|Chromatiales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_310622_1 546268.NEISUBOT_05178 6.02e-12 71.6 COG0741@1|root,COG1511@1|root,COG0741@2|Bacteria,COG1511@2|Bacteria,1R43Q@1224|Proteobacteria,2W06V@28216|Betaproteobacteria 28216|Betaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_380937_1 1095769.CAHF01000011_gene2427 1.55e-101 299.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,473MV@75682|Oxalobacteraceae 28216|Betaproteobacteria K UTRA frlR - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_1021239_1 1000565.METUNv1_02882 6.35e-48 155.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria,2KWFU@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_355213_1 1121035.AUCH01000013_gene3093 6.99e-132 377.0 COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,2WGYK@28216|Betaproteobacteria,2KZWV@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S single cluster domain - - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_533992_1 1120983.KB894571_gene2324 2.06e-22 97.8 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,1JNTV@119043|Rhodobiaceae 28211|Alphaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_533992_2 1538295.JY96_14295 1.72e-26 101.0 COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,2VX1P@28216|Betaproteobacteria,1KP1I@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Acyl-ACP thioesterase - - - - - - - - - - - - 4HBT_2,Acyl-ACP_TE k59_57350_1 1068980.ARVW01000001_gene3368 6.55e-53 186.0 COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4DY3H@85010|Pseudonocardiales 201174|Actinobacteria O Heat shock 70 kDa protein dnaK GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1124974_1 1223521.BBJX01000004_gene2334 1.11e-116 342.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,4AA48@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1021264_1 296591.Bpro_3337 9.73e-98 308.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,4A9P0@80864|Comamonadaceae 28216|Betaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_380978_1 1268622.AVS7_00660 1.39e-12 68.9 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,2VIGD@28216|Betaproteobacteria,4AGBD@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase k59_913037_1 700598.Niako_5719 3.9e-58 192.0 COG0373@1|root,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,1IQ3B@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_380982_1 1121035.AUCH01000012_gene2962 4.45e-129 375.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KV7G@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_767385_1 1120977.JHUX01000006_gene311 1.09e-117 345.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,3NK2W@468|Moraxellaceae 1236|Gammaproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_272660_1 760192.Halhy_1044 7.13e-86 277.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,1IPTQ@117747|Sphingobacteriia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_127817_1 468059.AUHA01000002_gene1108 1.97e-107 327.0 COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,1IQXV@117747|Sphingobacteriia 976|Bacteroidetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_92540_1 395493.BegalDRAFT_0703 2.76e-39 149.0 COG1216@1|root,COG3551@1|root,COG4627@1|root,COG1216@2|Bacteria,COG3551@2|Bacteria,COG4627@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,46246@72273|Thiotrichales 72273|Thiotrichales M glycosyl transferase, family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_843340_1 1123278.KB893603_gene1814 1.81e-42 152.0 COG2603@1|root,COG2603@2|Bacteria,4NH7W@976|Bacteroidetes,47KFW@768503|Cytophagia 976|Bacteroidetes S Rhodanese Homology Domain - - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_412518_1 199310.c5424 7.75e-64 210.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_412518_2 1124991.MU9_444 5.63e-80 256.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1RPS2@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_945620_1 1123367.C666_08895 1.19e-143 429.0 2DBCS@1|root,2Z8FF@2|Bacteria,1QVT2@1224|Proteobacteria,2WGTR@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_381013_1 1268068.PG5_64470 1.73e-12 66.2 COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,1S3HP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_734098_1 497964.CfE428DRAFT_0238 2.03e-87 290.0 COG2010@1|root,COG2010@2|Bacteria,46TSG@74201|Verrucomicrobia 74201|Verrucomicrobia C Protein of unknown function (DUF1549) - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_210793_1 614083.AWQR01000044_gene2010 6.6e-113 344.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,4AAEW@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_230995_1 887898.HMPREF0551_1772 3.99e-17 79.0 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,2VI5R@28216|Betaproteobacteria,1K1K2@119060|Burkholderiaceae 28216|Betaproteobacteria E abc transporter related modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_230995_2 264198.Reut_A0634 5.84e-39 138.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,1K2MC@119060|Burkholderiaceae 28216|Betaproteobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_588505_1 62928.azo1551 2.6e-101 311.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,2KV73@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_697641_1 1163398.AJJP01000177_gene1057 6.02e-15 69.3 COG2308@1|root,COG2308@2|Bacteria 2|Bacteria S glutamate-cysteine ligase activity gcs2 - - - - - - - - - - - CP_ATPgrasp_1,CP_ATPgrasp_2 k59_697641_2 1235457.C404_09155 6.82e-40 139.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2WGQC@28216|Betaproteobacteria,1KIFI@119060|Burkholderiaceae 28216|Betaproteobacteria C ferredoxin--nadp reductase fpr - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_21102_1 1298593.TOL_2127 1.67e-140 400.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XI7Z@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_165808_1 614083.AWQR01000041_gene790 5.61e-126 380.0 COG4389@1|root,COG4389@2|Bacteria,1MWEH@1224|Proteobacteria,2VIZV@28216|Betaproteobacteria,4AC23@80864|Comamonadaceae 28216|Betaproteobacteria L site-specific recombinase - - - - - - - - - - - - SpecificRecomb k59_213650_1 1000565.METUNv1_01712 1.65e-35 132.0 2AIFB@1|root,318WV@2|Bacteria,1Q13N@1224|Proteobacteria,2W62D@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_735745_2 1454004.AW11_02211 1.66e-18 84.3 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VJEB@28216|Betaproteobacteria 28216|Betaproteobacteria D AAA domain yveL - 2.7.10.1 ko:K08252,ko:K16692 - - - - ko00000,ko01000,ko01001 - - - AAA_31,GNVR,Wzz k59_489041_1 596154.Alide2_1206 4.23e-94 279.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2VIRB@28216|Betaproteobacteria,4AA3R@80864|Comamonadaceae 28216|Betaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_735754_1 1458427.BAWN01000009_gene625 3.48e-54 192.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,4AE2U@80864|Comamonadaceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,PAS_9,dCache_1 k59_984870_1 1223521.BBJX01000008_gene1324 4.02e-98 291.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,4AA6R@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Squalene phytoene synthase hpnD - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_590128_1 1349767.GJA_1124 1.48e-33 128.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2VMWN@28216|Betaproteobacteria,472D7@75682|Oxalobacteraceae 28216|Betaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_22798_1 1198452.Jab_2c33670 2.67e-87 276.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,473CU@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC transporter transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1023368_2 1120977.JHUX01000003_gene2058 9e-25 104.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,3NIH3@468|Moraxellaceae 1236|Gammaproteobacteria I acyl-CoA dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1095983_1 640081.Dsui_0050 5.9e-86 262.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,2KVGR@206389|Rhodocyclales 206389|Rhodocyclales G Aldolase fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_414189_1 381666.H16_B2398 1.38e-113 345.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2VJ6Z@28216|Betaproteobacteria,1K59Z@119060|Burkholderiaceae 28216|Betaproteobacteria S alkaline phosphatase phoX - - ko:K07093 - - - - ko00000 - - - DUF839 k59_735797_1 1177181.T9A_00178 1.24e-24 106.0 2CEM3@1|root,2ZGCF@2|Bacteria,1PBH6@1224|Proteobacteria,1SW4E@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_735797_2 62977.ACIAD0780 1.06e-16 81.6 2EXMM@1|root,33QXG@2|Bacteria,1NRHQ@1224|Proteobacteria,1SM8D@1236|Gammaproteobacteria,3NIQE@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_947233_1 640081.Dsui_0421 1.85e-43 157.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2VI5K@28216|Betaproteobacteria,2KUD9@206389|Rhodocyclales 206389|Rhodocyclales P carbonic anhydrase ecaA - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase k59_1126936_1 1121940.AUDZ01000011_gene1305 3.86e-50 179.0 COG0463@1|root,COG1216@1|root,COG0463@2|Bacteria,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1XP1Z@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_36993_1 640081.Dsui_1982 9.73e-149 428.0 COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,2KUYT@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.7.4 ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - GTP_EFTU k59_644263_1 1000565.METUNv1_00282 6.29e-09 55.5 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VJXH@28216|Betaproteobacteria,2KU9N@206389|Rhodocyclales 206389|Rhodocyclales P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component nasD - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_644263_2 1000565.METUNv1_02803 3.09e-62 193.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KWDE@206389|Rhodocyclales 206389|Rhodocyclales H molybdopterin-guanine dinucleotide biosynthesis protein - - - ko:K03753 - - - - ko00000 - - - MobB k59_1072595_1 1000565.METUNv1_02765 7.91e-80 256.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,2KUGP@206389|Rhodocyclales 206389|Rhodocyclales S ABC transporter abcZ - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_430006_1 987059.RBXJA2T_03267 2.24e-91 297.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,1KJ6A@119065|unclassified Burkholderiales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_286927_2 1000565.METUNv1_02098 1.16e-62 196.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,2KWGG@206389|Rhodocyclales 206389|Rhodocyclales S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_72400_1 530564.Psta_2354 3.74e-44 164.0 COG5492@1|root,COG5492@2|Bacteria,2IY8J@203682|Planctomycetes 203682|Planctomycetes N Protein of unknown function (DUF1549) - - - - - - - - - - - - PSCyt2,PSD1 k59_501511_1 1123367.C666_07930 1.47e-32 125.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales 206389|Rhodocyclales M (Lipo)protein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_501511_2 1000565.METUNv1_02687 1.21e-24 99.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,2KUG2@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_786703_1 1000565.METUNv1_03381 1.62e-68 223.0 2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria,2KVGT@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_786703_2 1000565.METUNv1_03380 1.16e-270 746.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,2KVEJ@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS_8 k59_786703_3 1000565.METUNv1_03379 1.05e-153 432.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KUNU@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_715319_1 1000565.METUNv1_00608 6.1e-153 472.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales 206389|Rhodocyclales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1326_2 1000565.METUNv1_01906 3.84e-145 411.0 COG1192@1|root,COG1192@2|Bacteria,1Q9Z3@1224|Proteobacteria,2VKUV@28216|Betaproteobacteria,2KVXM@206389|Rhodocyclales 206389|Rhodocyclales D ATPases involved in chromosome partitioning - - - - - - - - - - - - - k59_1326_3 1000565.METUNv1_01907 7.78e-160 452.0 COG0500@1|root,COG0500@2|Bacteria,1QVCU@1224|Proteobacteria,2WGQP@28216|Betaproteobacteria,2KZWC@206389|Rhodocyclales 206389|Rhodocyclales Q methyltransferase - - - - - - - - - - - - Methyltransf_25 k59_536428_1 397945.Aave_3548 1.79e-94 287.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,4AA11@80864|Comamonadaceae 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB2 - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_536428_2 640081.Dsui_1433 9.34e-16 74.7 COG1871@1|root,COG1871@2|Bacteria,1RI55@1224|Proteobacteria,2VUAC@28216|Betaproteobacteria,2KWWX@206389|Rhodocyclales 206389|Rhodocyclales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_679196_2 1000565.METUNv1_00569 1.7e-178 510.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,2KVHT@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_180173_2 614083.AWQR01000051_gene3433 3.03e-27 109.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,4A9Z0@80864|Comamonadaceae 28216|Betaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K02346,ko:K03502 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_786709_1 29581.BW37_04343 5.41e-66 224.0 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2WBW0@28216|Betaproteobacteria,476JM@75682|Oxalobacteraceae 28216|Betaproteobacteria H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_822126_1 1000565.METUNv1_02446 2.73e-115 337.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,2KVQA@206389|Rhodocyclales 206389|Rhodocyclales Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - 3.7.1.20 ko:K16165 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R01085 RC00326,RC00446 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_323032_1 1000565.METUNv1_03890 3.71e-165 470.0 COG2304@1|root,COG2304@2|Bacteria,1MX8R@1224|Proteobacteria,2VT5A@28216|Betaproteobacteria 28216|Betaproteobacteria S von Willebrand factor (vWF) type A domain - - - ko:K16259 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - VWA_2 k59_323032_2 1000565.METUNv1_03891 1.49e-85 256.0 2A8K8@1|root,30XNK@2|Bacteria,1PJHT@1224|Proteobacteria,2VXGV@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_323032_3 1000565.METUNv1_03892 1.42e-26 105.0 COG2304@1|root,COG2304@2|Bacteria,1QRQ4@1224|Proteobacteria,2W9WT@28216|Betaproteobacteria,2KZGA@206389|Rhodocyclales 2|Bacteria S von Willebrand factor type A domain - - - ko:K07114,ko:K16257 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_607591_1 1123024.AUII01000020_gene3199 0.000475 47.0 COG1670@1|root,COG1670@2|Bacteria,2HAFI@201174|Actinobacteria,4DY57@85010|Pseudonocardiales 201174|Actinobacteria J PFAM Acetyltransferase (GNAT) family rimJ - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_143991_1 1000565.METUNv1_00890 1.76e-20 87.8 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VIY9@28216|Betaproteobacteria,2KYDR@206389|Rhodocyclales 206389|Rhodocyclales M Polysaccharide biosynthesis/export protein gumB - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_143991_2 1000565.METUNv1_00889 4.39e-127 370.0 COG0760@1|root,COG0760@2|Bacteria,1R4EF@1224|Proteobacteria,2VK6Z@28216|Betaproteobacteria,2KYWC@206389|Rhodocyclales 206389|Rhodocyclales O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_715329_1 1000565.METUNv1_02336 1.02e-142 417.0 COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,2VK1M@28216|Betaproteobacteria,2KUAQ@206389|Rhodocyclales 206389|Rhodocyclales S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - VWA_CoxE k59_180183_1 640081.Dsui_3460 3.45e-31 111.0 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,2VTX1@28216|Betaproteobacteria,2KX3N@206389|Rhodocyclales 206389|Rhodocyclales D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k59_180183_2 1121035.AUCH01000013_gene3168 1.02e-72 224.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,2VJFP@28216|Betaproteobacteria,2KV0W@206389|Rhodocyclales 206389|Rhodocyclales D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_358404_1 365044.Pnap_1766 7.51e-103 319.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,4AC0C@80864|Comamonadaceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_108219_1 1297863.APJF01000021_gene164 1.43e-45 154.0 COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - - - - - - - - - - Glyco_tranf_2_3 k59_108219_2 1121374.KB891585_gene2013 3.32e-11 63.2 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_215236_1 397945.Aave_2355 3.29e-80 261.0 COG3170@1|root,COG3170@2|Bacteria,1N4R0@1224|Proteobacteria,2VPR6@28216|Betaproteobacteria,4AIY2@80864|Comamonadaceae 28216|Betaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - P22_portal k59_1072654_1 640081.Dsui_0089 1.47e-09 64.7 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUJI@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,sCache_2 k59_286950_1 1000565.METUNv1_03462 0.000129 50.8 COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,2KXG7@206389|Rhodocyclales 206389|Rhodocyclales S Alkaline phosphatase - - - - - - - - - - - - - k59_430057_1 1000565.METUNv1_02383 3.25e-111 327.0 COG1493@1|root,COG1493@2|Bacteria,1QWDD@1224|Proteobacteria,2WH4H@28216|Betaproteobacteria 28216|Betaproteobacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - - - - - - - - - - - k59_1036441_1 338969.Rfer_0403 4.65e-107 323.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2VIT5@28216|Betaproteobacteria,4A9TV@80864|Comamonadaceae 28216|Betaproteobacteria E Peptidase M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1036441_2 614083.AWQR01000025_gene3753 3.32e-67 211.0 COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,4ABCT@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the hyi family hyi - 5.3.1.22,5.3.1.35 ko:K01816,ko:K22131 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_644332_1 1000565.METUNv1_03044 1.1e-105 313.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,2KVRW@206389|Rhodocyclales 206389|Rhodocyclales F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_144011_1 1120977.JHUX01000003_gene807 1.76e-104 313.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,3NJHP@468|Moraxellaceae 1236|Gammaproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_430068_1 243365.CV_3438 5.42e-62 217.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KQ5R@206351|Neisseriales 206351|Neisseriales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_964802_1 1000565.METUNv1_03425 7.97e-90 290.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY9@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_286972_1 1121033.AUCF01000003_gene3213 7.1e-39 143.0 COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,2TRKE@28211|Alphaproteobacteria,2JQ59@204441|Rhodospirillales 204441|Rhodospirillales K IrrE N-terminal-like domain - - - ko:K07110 - - - - ko00000,ko03000 - - - DUF2083,Peptidase_M78 k59_323087_1 248742.XP_005651898.1 5.96e-29 118.0 COG0515@1|root,KOG0192@2759|Eukaryota,37PGG@33090|Viridiplantae,34KHE@3041|Chlorophyta 3041|Chlorophyta T Belongs to the protein kinase superfamily - - - - - - - - - - - - Pkinase_Tyr k59_430464_1 1198452.Jab_1c19320 3.36e-30 117.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2VNAZ@28216|Betaproteobacteria,473PB@75682|Oxalobacteraceae 28216|Betaproteobacteria JM Nucleotidyl transferase - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_430464_2 1198452.Jab_1c19330 3.15e-38 139.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,473TM@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the mannose-6-phosphate isomerase type 2 family xanB - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_1000863_1 335283.Neut_1469 2.08e-64 212.0 COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2VP0D@28216|Betaproteobacteria,374H7@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM phage major capsid protein, HK97 - - - - - - - - - - - - Phage_capsid k59_251553_1 1000565.METUNv1_00477 3.84e-102 320.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KY21@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Response_reg k59_1073064_1 768671.ThimaDRAFT_3920 1.79e-43 160.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_572299_1 991.IW20_08330 2.86e-16 84.3 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,4NGRJ@976|Bacteroidetes,1HZ7Y@117743|Flavobacteriia,2P050@237|Flavobacterium 976|Bacteroidetes O Pregnancy-associated plasma protein-A - - - - - - - - - - - - PKD,Peptidase_M43,fn3 k59_251555_1 153721.MYP_1519 3.03e-111 328.0 COG0845@1|root,COG0845@2|Bacteria,4NEXN@976|Bacteroidetes,47J8Y@768503|Cytophagia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_572305_2 887062.HGR_15309 6.69e-49 167.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,4A9RX@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM AAA ATPase central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_787079_1 1000565.METUNv1_00184 1.23e-127 387.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,2KUAW@206389|Rhodocyclales 206389|Rhodocyclales E aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_644753_1 1408164.MOLA814_00885 3.97e-99 311.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2VHT2@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_358759_3 1273125.Rrhod_0724 0.000243 43.1 2AR8S@1|root,31GIM@2|Bacteria,2HCA2@201174|Actinobacteria,4G80B@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_965033_1 1000565.METUNv1_01139 1.82e-47 168.0 COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,2VI7P@28216|Betaproteobacteria,2KUFI@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_857888_1 1122603.ATVI01000005_gene3435 1.66e-17 83.2 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,1X5MP@135614|Xanthomonadales 135614|Xanthomonadales S Mo-co oxidoreductase dimerisation domain - - - - - - - - - - - - Mo-co_dimer,Oxidored_molyb k59_857888_2 1000565.METUNv1_01901 4.03e-81 250.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2VIY7@28216|Betaproteobacteria,2KW97@206389|Rhodocyclales 206389|Rhodocyclales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_607859_1 1000565.METUNv1_02149 1.21e-224 638.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,2KV7T@206389|Rhodocyclales 206389|Rhodocyclales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_822454_1 1266925.JHVX01000004_gene1150 1.15e-39 138.0 COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,2VU8X@28216|Betaproteobacteria,373CU@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF423) ygdD - - - - - - - - - - - DUF423 k59_502033_1 1000565.METUNv1_00465 1.27e-167 469.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,2KVKX@206389|Rhodocyclales 206389|Rhodocyclales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_1000883_1 1538295.JY96_07105 9.58e-64 196.0 COG2824@1|root,COG2824@2|Bacteria,1RGUU@1224|Proteobacteria,2VSKS@28216|Betaproteobacteria,1KMCC@119065|unclassified Burkholderiales 28216|Betaproteobacteria P PhnA Zinc-Ribbon phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_1000883_2 1000565.METUNv1_03251 5.18e-88 281.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,2KUE2@206389|Rhodocyclales 206389|Rhodocyclales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_644769_1 1000565.METUNv1_00417 3.06e-237 687.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,2WGSC@28216|Betaproteobacteria,2KVJK@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4 k59_750955_1 314271.RB2654_21438 3.48e-13 71.2 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_750955_2 1000565.METUNv1_03375 4.31e-70 218.0 COG3165@1|root,COG3165@2|Bacteria,1N314@1224|Proteobacteria,2VU2B@28216|Betaproteobacteria,2KWVA@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_929045_1 1122604.JONR01000057_gene3537 6.09e-78 259.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_502038_1 768671.ThimaDRAFT_1698 1.01e-114 374.0 COG0642@1|root,COG2202@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WY5G@135613|Chromatiales 135613|Chromatiales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - CBS,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_679492_1 640081.Dsui_3446 4.16e-85 259.0 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,2KX0U@206389|Rhodocyclales 206389|Rhodocyclales H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_215535_1 1000565.METUNv1_00366 2.7e-201 563.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,2KUQE@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_215535_2 1000565.METUNv1_00365 2.74e-119 342.0 2DPY2@1|root,333WA@2|Bacteria,1NDT4@1224|Proteobacteria,2WC4I@28216|Betaproteobacteria,2KXQT@206389|Rhodocyclales 206389|Rhodocyclales S AP2 domain - - - - - - - - - - - - AP2 k59_894031_1 1000565.METUNv1_03426 1.79e-56 176.0 COG0347@1|root,COG0347@2|Bacteria,1N32M@1224|Proteobacteria,2VUEY@28216|Betaproteobacteria,2KWXV@206389|Rhodocyclales 206389|Rhodocyclales K Nitrogen regulatory protein P-II - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_894031_2 62928.azo2926 3.47e-36 134.0 COG3103@1|root,COG3103@2|Bacteria,1QVCP@1224|Proteobacteria 1224|Proteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - - k59_894031_3 748280.NH8B_3097 2.79e-18 85.9 2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria 28216|Betaproteobacteria S YMGG-like Gly-zipper - - - - - - - - - - - - Gly-zipper_OmpA,Gly-zipper_YMGG k59_894031_4 1000565.METUNv1_03169 2.25e-111 330.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KUPW@206389|Rhodocyclales 206389|Rhodocyclales DM Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_108553_1 76869.PputGB1_2571 9.46e-70 233.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1YXFB@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_685516_1 204773.HEAR2770 1.54e-114 354.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,472GD@75682|Oxalobacteraceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_191984_1 640081.Dsui_0941 3.95e-27 103.0 COG1393@1|root,COG1393@2|Bacteria,1MZ7Z@1224|Proteobacteria,2VT4B@28216|Betaproteobacteria,2KX0K@206389|Rhodocyclales 206389|Rhodocyclales P ArsC family - - - - - - - - - - - - ArsC k59_191984_2 640081.Dsui_0940 8.08e-24 101.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VKXT@28216|Betaproteobacteria,2KU7Y@206389|Rhodocyclales 206389|Rhodocyclales KT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_44883_1 1122951.ATUE01000006_gene1264 3.76e-43 152.0 COG3115@1|root,COG3115@2|Bacteria,1PBVP@1224|Proteobacteria,1SWKN@1236|Gammaproteobacteria,3NM5I@468|Moraxellaceae 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA - - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_612587_1 1157708.KB907457_gene2808 4.49e-155 482.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,4AAZM@80864|Comamonadaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_191987_2 375286.mma_0167 3.03e-36 124.0 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,2VVR4@28216|Betaproteobacteria,474YC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Membrane fusogenic activity yqiC - - ko:K09806 - - - - ko00000 - - - BMFP k59_191987_3 1144319.PMI16_04860 1.1e-30 118.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,472HN@75682|Oxalobacteraceae 28216|Betaproteobacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_401838_1 1000565.METUNv1_03830 2.72e-85 255.0 2C80Q@1|root,30ICB@2|Bacteria,1N35V@1224|Proteobacteria,2VVGE@28216|Betaproteobacteria,2KWJ6@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1113511_1 395495.Lcho_4135 1.01e-27 111.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2VNUX@28216|Betaproteobacteria,1KNES@119065|unclassified Burkholderiales 28216|Betaproteobacteria S NHL repeat - - - - - - - - - - - - NHL k59_1113511_2 1158318.ATXC01000002_gene1526 1.13e-05 52.4 COG3005@1|root,COG3005@2|Bacteria,2G4KY@200783|Aquificae 200783|Aquificae C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_80322_1 1122951.ATUE01000007_gene813 8.25e-82 263.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL helicase yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_220231_1 595537.Varpa_4044 1.22e-69 212.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2VSP4@28216|Betaproteobacteria,4AEC0@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM nitrite reductase NAD(P)H , small subunit nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_220231_2 338969.Rfer_2559 1.95e-40 148.0 COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,4AB7E@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_970945_1 334545.CCMG01000015_gene1285 6.33e-86 276.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,47EXV@766|Rickettsiales 766|Rickettsiales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_970945_2 3885.XP_007138957.1 1.01e-67 223.0 COG1622@1|root,KOG4767@2759|Eukaryota,37T4F@33090|Viridiplantae,3GGAX@35493|Streptophyta,4JT1W@91835|fabids 35493|Streptophyta C Cytochrome C oxidase, subunit cox2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0042773,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564 - ko:K02261 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX2,COX2_TM k59_970945_3 10042.XP_006973917.1 1.12e-205 593.0 COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3BCEE@33208|Metazoa,3CU79@33213|Bilateria,489CP@7711|Chordata,497ZQ@7742|Vertebrata,3J34Z@40674|Mammalia,35DYV@314146|Euarchontoglires,4Q0CE@9989|Rodentia 33208|Metazoa C Produces ATP from ADP in the presence of a proton gradient across the membrane ATP5A1 GO:0000166,GO:0000275,GO:0001936,GO:0001937,GO:0003674,GO:0003824,GO:0005102,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008285,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010594,GO:0010595,GO:0010632,GO:0010634,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030334,GO:0030335,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040012,GO:0040017,GO:0042127,GO:0042287,GO:0042288,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043168,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0043531,GO:0043532,GO:0043535,GO:0043536,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045121,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050678,GO:0050680,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051270,GO:0051272,GO:0055085,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0097159,GO:0097367,GO:0098589,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098805,GO:0098857,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:2000145,GO:2000147 - ko:K02132 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1008959_1 402626.Rpic_1385 0.000129 45.1 2DQ6K@1|root,334ZA@2|Bacteria,1NE2B@1224|Proteobacteria,2VWAU@28216|Betaproteobacteria,1KAQB@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_473026_1 596153.Alide_2056 8.42e-60 203.0 COG2801@1|root,COG2801@2|Bacteria,1QWUR@1224|Proteobacteria,2VNEY@28216|Betaproteobacteria,4AD01@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_334674_1 1000565.METUNv1_02684 1.45e-55 183.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KW8Q@206389|Rhodocyclales 206389|Rhodocyclales S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_334674_2 1000565.METUNv1_02685 5.02e-160 454.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KVFI@206389|Rhodocyclales 206389|Rhodocyclales S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_3 k59_366620_1 1198452.Jab_1c13740 7.48e-168 477.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,473CV@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1043862_1 1367847.JCM7686_1007 4.65e-42 151.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria,2PWSM@265|Paracoccus 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_1008964_1 1000565.METUNv1_03058 3.29e-312 869.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales 206389|Rhodocyclales L DNA topoisomerase III - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k59_513413_1 1121456.ATVA01000014_gene598 9.44e-48 173.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_4,PAS_9 k59_722158_1 358220.C380_22695 8.15e-96 286.0 COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2VIRJ@28216|Betaproteobacteria,4AAC0@80864|Comamonadaceae 28216|Betaproteobacteria S Oxidoreductase ligC - 1.1.1.312 ko:K10219 ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220 M00533 R04278,R04279,R04418,R04419 RC00251,RC00254 ko00000,ko00001,ko00002,ko01000 - - - ADH_zinc_N,GFO_IDH_MocA k59_864558_1 1122605.KB893626_gene2355 1.96e-36 135.0 COG0056@1|root,COG0056@2|Bacteria,4NFZW@976|Bacteroidetes,1IP4E@117747|Sphingobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_864558_2 1267211.KI669560_gene1033 1.27e-19 83.2 COG0454@1|root,COG0456@2|Bacteria,4NWTW@976|Bacteroidetes,1IZJT@117747|Sphingobacteriia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_756781_1 748247.AZKH_0340 3.9e-75 241.0 COG3391@1|root,COG3391@2|Bacteria,1MYI5@1224|Proteobacteria,2VNCM@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM NHL repeat containing protein - - - - - - - - - - - - - k59_756781_2 864051.BurJ1DRAFT_4175 8.55e-26 109.0 COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_578229_1 1000565.METUNv1_03067 1.31e-25 99.8 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_578229_2 1000565.METUNv1_03068 1.97e-194 560.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KV2P@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_830625_1 631362.Thi970DRAFT_03885 1.29e-65 208.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1WXHM@135613|Chromatiales 135613|Chromatiales IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_830625_2 1353529.M899_1545 7.9e-17 75.5 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2MT19@213481|Bdellovibrionales,2WKIR@28221|Deltaproteobacteria 213481|Bdellovibrionales J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Methyltrn_RNA_4,tRNA_m1G_MT k59_150878_1 1385515.N791_09945 3.23e-79 261.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1X3ZB@135614|Xanthomonadales 135614|Xanthomonadales L Type I site-specific restriction-modification system R (restriction) subunit and related helicases - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_259298_1 395494.Galf_2031 7.05e-76 244.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,44VPB@713636|Nitrosomonadales 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_578241_1 338969.Rfer_0571 2.82e-75 234.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,4AB81@80864|Comamonadaceae 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_656715_1 395494.Galf_0680 2.35e-85 271.0 28JTB@1|root,2Z9IM@2|Bacteria,1NP81@1224|Proteobacteria,2WHPG@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1043891_1 1000565.METUNv1_00693 1.29e-42 153.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VMT8@28216|Betaproteobacteria,2KV87@206389|Rhodocyclales 206389|Rhodocyclales M Phospholipase A1 - - - - - - - - - - - - PLA1 k59_442431_1 266264.Rmet_4085 8.95e-91 281.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2VKXB@28216|Betaproteobacteria,1K54B@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the alkaline phosphatase family phoA2 - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_970987_1 1000565.METUNv1_01535 2.14e-92 278.0 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,2VMUW@28216|Betaproteobacteria,2KZT6@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_970987_2 1000565.METUNv1_01534 5.91e-19 85.9 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,2KVWT@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,HDOD k59_401909_1 765913.ThidrDRAFT_1067 7.91e-35 138.0 COG0642@1|root,COG0784@1|root,COG3614@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg k59_473078_1 1000565.METUNv1_01985 1e-161 466.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VM62@28216|Betaproteobacteria,2KY65@206389|Rhodocyclales 206389|Rhodocyclales G PQQ-like domain - - - - - - - - - - - - PQQ k59_295860_2 633149.Bresu_0594 2.22e-52 174.0 COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,2TVY6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_442443_1 522306.CAP2UW1_4155 1.08e-60 200.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1KQCB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_401916_1 1247963.JPHU01000010_gene2258 2.49e-06 47.0 COG1426@1|root,COG1426@2|Bacteria,1NBD0@1224|Proteobacteria,2UGGH@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Helix-turn-helix - - - - - - - - - - - - HTH_3,HTH_31 k59_115956_1 1122951.ATUE01000008_gene35 6.39e-71 234.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,3NM2Z@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_220944_1 1000565.METUNv1_03150 5.92e-66 213.0 COG3240@1|root,COG3240@2|Bacteria,1MWDI@1224|Proteobacteria,2VTBY@28216|Betaproteobacteria,2KXBE@206389|Rhodocyclales 206389|Rhodocyclales I GDSL-like Lipase/Acylhydrolase - - - ko:K12686 - - - - ko00000,ko02000,ko02044 1.B.12.8 - - Lipase_GDSL,VPEP k59_296720_1 700598.Niako_5644 2.99e-100 319.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1IPC5@117747|Sphingobacteriia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_193425_1 232721.Ajs_0664 6.56e-34 126.0 COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VHXM@28216|Betaproteobacteria,4ABP9@80864|Comamonadaceae 28216|Betaproteobacteria C Luciferase family limB - - - - - - - - - - - Bac_luciferase k59_193425_2 338969.Rfer_3168 3.29e-31 116.0 COG0664@1|root,COG0664@2|Bacteria,1RATP@1224|Proteobacteria,2VQKD@28216|Betaproteobacteria,4ADQR@80864|Comamonadaceae 28216|Betaproteobacteria K regulatory protein Crp - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_971661_1 398527.Bphyt_1443 1.27e-11 63.9 COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2VT16@28216|Betaproteobacteria,1K73G@119060|Burkholderiaceae 28216|Betaproteobacteria U Biopolymer transport protein ExbD/TolR exbD2 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_971661_2 1005048.CFU_3173 1.42e-56 180.0 COG0848@1|root,COG0848@2|Bacteria,1RH4U@1224|Proteobacteria,2VSF4@28216|Betaproteobacteria,474QD@75682|Oxalobacteraceae 28216|Betaproteobacteria U Biopolymer transport protein ExbD/TolR exbD1 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_971661_3 1005048.CFU_2988 2.5e-25 102.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,472IN@75682|Oxalobacteraceae 28216|Betaproteobacteria U MotA/TolQ/ExbB proton channel family exbB1 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_543705_1 946483.Cenrod_1856 1.39e-73 230.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria,4A9SV@80864|Comamonadaceae 28216|Betaproteobacteria T Two component signalling adaptor domain cheV1-2 - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_1086359_1 1000565.METUNv1_02784 9.15e-72 226.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,2KU7F@206389|Rhodocyclales 206389|Rhodocyclales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1086359_2 1000565.METUNv1_02785 3.64e-19 86.7 COG0705@1|root,COG0705@2|Bacteria,1PRTS@1224|Proteobacteria,2VM82@28216|Betaproteobacteria,2KXF8@206389|Rhodocyclales 206389|Rhodocyclales S Rhomboid family - - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Rhomboid k59_971667_1 279714.FuraDRAFT_0891 9.69e-90 276.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,2KQE6@206351|Neisseriales 206351|Neisseriales F Deoxyguanosinetriphosphate triphosphohydrolase dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD k59_81041_1 1000565.METUNv1_02908 5.66e-178 500.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,2KVZB@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_260133_2 1163617.SCD_n00147 6.51e-102 310.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria 28216|Betaproteobacteria E COG0626 Cystathionine beta-lyases cystathionine gamma-synthases metC - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K01761 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_367589_2 1265502.KB905951_gene865 9.44e-12 59.7 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,4AFBH@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_260134_1 1276756.AUEX01000002_gene418 1.28e-44 151.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,2VJFP@28216|Betaproteobacteria,4A9V6@80864|Comamonadaceae 28216|Betaproteobacteria D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_260134_2 296591.Bpro_0020 2.6e-53 174.0 COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,2VNVN@28216|Betaproteobacteria,4ADMC@80864|Comamonadaceae 28216|Betaproteobacteria D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C,MinC_N k59_1086385_1 765911.Thivi_4094 2.2e-46 160.0 COG0834@1|root,COG0834@2|Bacteria,1QQXM@1224|Proteobacteria,1S7SU@1236|Gammaproteobacteria,1WYPP@135613|Chromatiales 135613|Chromatiales ET Bacterial periplasmic substrate-binding proteins - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_1086385_2 1207063.P24_03490 5.42e-14 73.2 COG0500@1|root,COG0500@2|Bacteria,1N1Q5@1224|Proteobacteria,2UE51@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_722916_1 522306.CAP2UW1_3451 1.88e-79 244.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,2VH2Y@28216|Betaproteobacteria 28216|Betaproteobacteria T 'signal transduction protein - - - - - - - - - - - - HDOD k59_514780_1 926549.KI421517_gene2293 6.6e-55 191.0 COG0457@1|root,COG0457@2|Bacteria,4NH2F@976|Bacteroidetes,47N0J@768503|Cytophagia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_514790_2 365044.Pnap_1400 3.07e-20 88.6 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria,4AAGJ@80864|Comamonadaceae 28216|Betaproteobacteria S fumarate reductase succinate dehydrogenase flavoprotein domain protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_193484_2 1000565.METUNv1_00718 6.31e-21 90.9 COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,2KWJB@206389|Rhodocyclales 206389|Rhodocyclales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_971690_1 365044.Pnap_1570 2.26e-115 347.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2WHK4@28216|Betaproteobacteria 28216|Betaproteobacteria KT Nif-specific regulatory protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_336063_1 614083.AWQR01000021_gene236 1.91e-82 252.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,4A9QE@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_296770_1 1121451.DESAM_21420 2.17e-36 141.0 COG3852@1|root,COG5000@1|root,COG3852@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42Y7R@68525|delta/epsilon subdivisions,2WUCW@28221|Deltaproteobacteria,2MHJA@213115|Desulfovibrionales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS k59_841134_1 614083.AWQR01000046_gene3330 1e-39 143.0 2E8RT@1|root,3332S@2|Bacteria,1NCEC@1224|Proteobacteria,2VXCV@28216|Betaproteobacteria,4AFE3@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_841134_2 614083.AWQR01000046_gene3329 4.63e-58 185.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,4AAKG@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1093622_1 887062.HGR_05206 1.43e-28 112.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,4AD3F@80864|Comamonadaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_308311_1 43354.JOIJ01000011_gene2664 3.45e-42 156.0 COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4DYJ7@85010|Pseudonocardiales 201174|Actinobacteria I PFAM Acyltransferase - - - - - - - - - - - - Acyl_transf_3,Glyco_hydro_16 k59_410834_1 204773.HEAR0515 1e-121 355.0 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,2VISI@28216|Betaproteobacteria,473AC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - DUF932 k59_1058333_1 614083.AWQR01000022_gene71 8.73e-91 270.0 COG1309@1|root,COG1309@2|Bacteria,1P4J2@1224|Proteobacteria,2VHWF@28216|Betaproteobacteria,4ABFR@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N k59_459465_1 1121920.AUAU01000008_gene1683 1.23e-114 335.0 COG0190@1|root,COG0190@2|Bacteria 2|Bacteria F methenyltetrahydrofolate cyclohydrolase activity folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_90498_1 375286.mma_1125 6.68e-93 281.0 COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,2VHIB@28216|Betaproteobacteria,472GK@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2331) - - - - - - - - - - - - DUF2331 k59_911372_1 338969.Rfer_0172 1.72e-41 143.0 COG2010@1|root,COG2010@2|Bacteria,1PZ21@1224|Proteobacteria,2W347@28216|Betaproteobacteria,4AI4W@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_944069_1 1198452.Jab_2c19650 3.33e-72 244.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,4730W@75682|Oxalobacteraceae 28216|Betaproteobacteria S extracellular alpha-helical protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_981327_1 1198452.Jab_2c24190 1.22e-22 95.1 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,472VK@75682|Oxalobacteraceae 28216|Betaproteobacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1123294_1 1000565.METUNv1_00483 1.41e-84 264.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,2KVI3@206389|Rhodocyclales 206389|Rhodocyclales S SpoVR family - - - - - - - - - - - - SpoVR k59_1123294_2 1000565.METUNv1_00482 1.88e-141 409.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2VJE2@28216|Betaproteobacteria,2KV9U@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_586926_1 1121035.AUCH01000007_gene443 1.73e-46 163.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KVSS@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_674229_2 1502770.JQMG01000001_gene237 2.31e-32 121.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,2KMHV@206350|Nitrosomonadales 206350|Nitrosomonadales S cAMP phosphodiesterases class-II - - - - - - - - - - - - Lactamase_B_2 k59_352254_1 396588.Tgr7_2436 5.44e-53 169.0 COG1487@1|root,COG1487@2|Bacteria,1QU3C@1224|Proteobacteria 1224|Proteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase vapC - - - - - - - - - - - PIN k59_352254_2 1485545.JQLW01000011_gene1354 2.27e-13 65.5 COG2002@1|root,COG2002@2|Bacteria,1N296@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator, AbrB family - - - - - - - - - - - - MazE_antitoxin k59_352254_3 216595.PFLU_2137 2.02e-75 249.0 COG0210@1|root,COG0210@2|Bacteria,1PEJT@1224|Proteobacteria,1TCJ7@1236|Gammaproteobacteria,1YR2A@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L DNA helicase - - - - - - - - - - - - ResIII k59_981348_1 1235803.C825_00646 3.79e-37 140.0 COG0249@1|root,COG0249@2|Bacteria,4NE6X@976|Bacteroidetes,2FM62@200643|Bacteroidia,22W8S@171551|Porphyromonadaceae 976|Bacteroidetes L ATPase domain of DNA mismatch repair MUTS family mutS_2 - - - - - - - - - - - MutS_III,MutS_V k59_981348_2 1408433.JHXV01000002_gene463 4.57e-14 71.6 COG0750@1|root,COG0750@2|Bacteria,4NEAR@976|Bacteroidetes,1HXEV@117743|Flavobacteriia,2PAA1@246874|Cryomorphaceae 976|Bacteroidetes M Peptidase family M50 rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_352263_1 1408433.JHXV01000011_gene2009 4.71e-96 284.0 COG0463@1|root,COG0463@2|Bacteria,4PM68@976|Bacteroidetes,1IJKP@117743|Flavobacteriia,2PANZ@246874|Cryomorphaceae 976|Bacteroidetes M Glycosyl transferase family 2 dpm1 - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_352270_1 381666.H16_A0008 7.95e-132 399.0 COG1401@1|root,COG1401@2|Bacteria,1MYQM@1224|Proteobacteria,2VHB8@28216|Betaproteobacteria 28216|Betaproteobacteria V AAA domain (dynein-related subfamily) - - - ko:K07452 - - - - ko00000,ko01000,ko02048 - - - AAA_5 k59_1058419_1 640081.Dsui_1867 1.01e-70 235.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KZR6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_126131_1 983917.RGE_05630 2.17e-68 212.0 28HPC@1|root,2Z7XD@2|Bacteria,1REIX@1224|Proteobacteria,2VS60@28216|Betaproteobacteria,1KMBS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Domain of unknown function (DUF4337) - - - - - - - - - - - - DUF4337 k59_620798_1 338969.Rfer_1329 1.01e-52 172.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2VKZJ@28216|Betaproteobacteria,4AA0F@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM Phosphoserine phosphatase SerB serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_586950_1 709032.Sulku_2385 6.44e-13 71.2 COG0110@1|root,COG0110@2|Bacteria,1NWE6@1224|Proteobacteria,42T28@68525|delta/epsilon subdivisions,2YT0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - - k59_19248_1 614083.AWQR01000017_gene2287 2.13e-62 195.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,4AE0F@80864|Comamonadaceae 28216|Betaproteobacteria S Stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_841224_1 1123279.ATUS01000002_gene34 4.25e-116 342.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_208702_1 1000565.METUNv1_03883 2.1e-109 335.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KY8Z@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_90576_1 1122951.ATUE01000005_gene1954 1.41e-57 184.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,3NIRG@468|Moraxellaceae 1236|Gammaproteobacteria K phosphate regulon transcriptional regulatory protein PhoB phoB GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_352312_1 1000565.METUNv1_03909 2.83e-46 155.0 COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,2VK5Z@28216|Betaproteobacteria,2KV3T@206389|Rhodocyclales 206389|Rhodocyclales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_586958_1 243365.CV_1178 4.03e-76 251.0 COG4533@1|root,COG4533@2|Bacteria,1P7TJ@1224|Proteobacteria,2W57F@28216|Betaproteobacteria 2|Bacteria S ORF located using Glimmer GeneMark Blastx COG0747 sgrR GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K11925 - - - - ko00000,ko03000 - - - SBP_bac_5,SgrR_N k59_162247_1 1158292.JPOE01000002_gene2330 4.43e-98 300.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria,1KIT1@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_806120_1 987059.RBXJA2T_14546 5.65e-45 160.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2VIH0@28216|Betaproteobacteria,1KIWM@119065|unclassified Burkholderiales 28216|Betaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_270837_1 1502851.FG93_03272 8.05e-09 53.9 COG4691@1|root,COG4691@2|Bacteria,1NP6E@1224|Proteobacteria,2UKV5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Plasmid stability protein - - - ko:K21495 - - - - ko00000,ko02048 - - - - k59_270837_2 661087.HMPREF1008_00968 2.47e-12 67.4 COG4113@1|root,COG4113@2|Bacteria,2HV9I@201174|Actinobacteria,4CWII@84998|Coriobacteriia 84998|Coriobacteriia S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_270837_3 290317.Cpha266_1433 4.48e-29 114.0 COG3649@1|root,COG3649@2|Bacteria 2|Bacteria L CRISPR-associated protein Cas7 cas7c - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_806124_1 697282.Mettu_1883 8.82e-64 202.0 2DEM1@1|root,2ZNEB@2|Bacteria,1P8KJ@1224|Proteobacteria,1SVJ0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1019232_1 640081.Dsui_1197 1.73e-88 267.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KV4Z@206389|Rhodocyclales 206389|Rhodocyclales P Mg2 and Co2 transporter CorC - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_765919_1 338969.Rfer_2011 3.8e-114 345.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,4AAU8@80864|Comamonadaceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_586973_2 1244869.H261_12754 9.95e-14 71.2 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,2JRBA@204441|Rhodospirillales 204441|Rhodospirillales V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - ko:K13409 ko02010,ko04626,map02010,map04626 M00339 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_484785_1 381666.H16_A1007 2.95e-87 271.0 COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,2VGZR@28216|Betaproteobacteria,1K3UM@119060|Burkholderiaceae 28216|Betaproteobacteria F permease - - - ko:K03458 - - - - ko00000 2.A.40 - - Xan_ur_permease k59_55635_1 1321814.HMPREF9089_00886 4.19e-32 119.0 COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,25VAT@186806|Eubacteriaceae 186801|Clostridia C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_765942_1 1223521.BBJX01000008_gene1300 3.76e-108 331.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4A9M6@80864|Comamonadaceae 28216|Betaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_841303_1 234267.Acid_0759 3.74e-66 225.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - - - - - - - - - - DUF2920,Peptidase_S9 k59_352396_1 1000565.METUNv1_03768 7.33e-30 120.0 COG0367@1|root,COG0367@2|Bacteria,1R769@1224|Proteobacteria,2W1JM@28216|Betaproteobacteria 28216|Betaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_674395_1 1000565.METUNv1_03640 7.48e-95 278.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,2KW4R@206389|Rhodocyclales 206389|Rhodocyclales G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_944174_1 614083.AWQR01000005_gene907 2.36e-21 86.3 COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,2VSIB@28216|Betaproteobacteria,4AECV@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 k59_531210_1 864051.BurJ1DRAFT_1273 5.51e-85 266.0 COG0438@1|root,COG0438@2|Bacteria,1NT76@1224|Proteobacteria,2VZ5B@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 k59_1060233_1 596154.Alide2_3708 4.6e-05 45.4 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,4AFUD@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM UbiA prenyltransferase menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_733568_1 1396141.BATP01000060_gene4628 4.86e-24 98.2 COG1595@1|root,COG1595@2|Bacteria,46VJP@74201|Verrucomicrobia,2IU42@203494|Verrucomicrobiae 203494|Verrucomicrobiae K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2 k59_272053_1 296591.Bpro_3791 1.94e-110 325.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,4AB3Z@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_877465_1 1000565.METUNv1_02822 2.18e-185 521.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,2KUN2@206389|Rhodocyclales 206389|Rhodocyclales E acetylornithine aminotransferase argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_877468_1 296591.Bpro_3091 1.76e-80 247.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,4A9PX@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1060258_1 1122951.ATUE01000005_gene1573 1.24e-109 340.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,3NK8P@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_56773_1 1341155.FSS13T_08510 1.77e-49 179.0 COG3920@1|root,COG3920@2|Bacteria,4NINT@976|Bacteroidetes,1HWYS@117743|Flavobacteriia,2NVMV@237|Flavobacterium 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HATPase_c_2,HisKA_2,TPR_12,TPR_8 k59_354205_1 1121939.L861_20395 1.13e-21 95.9 COG0834@1|root,COG0834@2|Bacteria,1RDZV@1224|Proteobacteria,1S4VJ@1236|Gammaproteobacteria,1XKQX@135619|Oceanospirillales 135619|Oceanospirillales ET ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - - - - - - - - - - SBP_bac_3 k59_354205_2 1000565.METUNv1_03636 4.58e-34 124.0 28P5Y@1|root,2ZC0T@2|Bacteria,1RBDV@1224|Proteobacteria,2VZTY@28216|Betaproteobacteria,2KYJ2@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1020614_1 1144319.PMI16_04267 9.04e-67 206.0 COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2VTB1@28216|Betaproteobacteria,474EH@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_1124394_1 1276756.AUEX01000006_gene3095 1.25e-105 311.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,4ABIN@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_807238_1 1461579.CCNK01000036_gene1536 8.73e-89 284.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1Y6WZ@135625|Pasteurellales 135625|Pasteurellales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_56794_1 1000565.METUNv1_04046 1.11e-97 297.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria,2KVB8@206389|Rhodocyclales 206389|Rhodocyclales S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_427201_1 1123393.KB891330_gene807 1.1e-52 177.0 2D326@1|root,32TE3@2|Bacteria,1N94A@1224|Proteobacteria,2W8IE@28216|Betaproteobacteria,1KS7U@119069|Hydrogenophilales 119069|Hydrogenophilales S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_999217_1 426114.THI_1389 3.24e-122 369.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,1KJ09@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48,Glyco_hydro_77 k59_603289_1 1121035.AUCH01000015_gene2518 8.35e-80 249.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2VQ3C@28216|Betaproteobacteria,2KWSC@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_783013_1 640081.Dsui_1041 1.7e-82 256.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KUFP@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_783014_1 1408433.JHXV01000010_gene534 2.25e-05 45.4 COG0727@1|root,COG0727@2|Bacteria,4NJH9@976|Bacteroidetes,1HZQ3@117743|Flavobacteriia,2PAWU@246874|Cryomorphaceae 976|Bacteroidetes S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_783014_2 700598.Niako_5057 7.73e-23 99.8 COG3735@1|root,COG3735@2|Bacteria,4NGNW@976|Bacteroidetes,1IS2W@117747|Sphingobacteriia 976|Bacteroidetes S PFAM GumN - - - - - - - - - - - - TraB k59_1071656_1 190650.CC_1785 4.32e-18 85.5 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2KF2T@204458|Caulobacterales 204458|Caulobacterales M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - - - - - - - - - - OEP k59_1071656_2 1120919.AUBI01000009_gene228 1.31e-14 71.2 COG1309@1|root,COG1309@2|Bacteria,1PZUN@1224|Proteobacteria,2TQY3@28211|Alphaproteobacteria,2JZDD@204441|Rhodospirillales 204441|Rhodospirillales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_286192_1 1095769.CAHF01000006_gene1857 1.48e-14 71.6 COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,2VT33@28216|Betaproteobacteria,478TE@75682|Oxalobacteraceae 28216|Betaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_286192_2 1120985.AUMI01000021_gene2833 6.78e-07 51.6 COG2199@1|root,COG3706@2|Bacteria,1UYCS@1239|Firmicutes,4H3J7@909932|Negativicutes 909932|Negativicutes T Diguanylate cyclase (GGDEF) domain protein - - 2.7.7.65 ko:K18967 - - - - ko00000,ko01000,ko02000 9.B.34.1.1 - - FIST,FIST_C,GGDEF k59_322095_1 614083.AWQR01000029_gene2181 3.33e-142 412.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,4ABMX@80864|Comamonadaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1071661_1 365044.Pnap_0457 2.86e-155 452.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,4ABTR@80864|Comamonadaceae 28216|Betaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_500558_1 85643.Tmz1t_1230 3.71e-85 257.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,2VQRE@28216|Betaproteobacteria,2KUDE@206389|Rhodocyclales 206389|Rhodocyclales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_286193_1 1000565.METUNv1_00761 8.99e-84 258.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,2KV0C@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_286193_2 1000565.METUNv1_00760 1.02e-22 88.2 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,2KWYA@206389|Rhodocyclales 206389|Rhodocyclales J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_643364_1 1000565.METUNv1_02692 8.99e-83 268.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2VJMQ@28216|Betaproteobacteria,2KVQN@206389|Rhodocyclales 206389|Rhodocyclales HJ ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_723_1 1121035.AUCH01000005_gene37 8.03e-58 204.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_1071669_1 1000565.METUNv1_00718 4.12e-210 589.0 COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,2KWJB@206389|Rhodocyclales 206389|Rhodocyclales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_464677_1 640081.Dsui_3245 5.23e-29 107.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,2KWAM@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_464677_2 1101195.Meth11DRAFT_0668 6.75e-76 235.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,2KKPM@206350|Nitrosomonadales 206350|Nitrosomonadales F PFAM Glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_678666_2 1000565.METUNv1_02437 4.14e-84 248.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,2KWD3@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_71919_1 1100720.ALKN01000045_gene488 4.58e-44 150.0 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,2VSGZ@28216|Betaproteobacteria,4ADKX@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0307 family yjgA - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_71919_2 614083.AWQR01000055_gene1994 8.01e-35 130.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,4ABC3@80864|Comamonadaceae 28216|Betaproteobacteria S peptidase U62, modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1071685_1 1395516.PMO01_06295 0.000659 47.4 28MQX@1|root,2ZAZM@2|Bacteria,1RKF3@1224|Proteobacteria,1SAIZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_678672_1 398527.Bphyt_2984 1.78e-14 73.2 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,1K1EZ@119060|Burkholderiaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_678672_2 497321.C664_00790 1.26e-92 277.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,2KUTX@206389|Rhodocyclales 206389|Rhodocyclales C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_464691_1 1458275.AZ34_15380 8.84e-122 352.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2VIKF@28216|Betaproteobacteria,4AAS4@80864|Comamonadaceae 28216|Betaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_714589_1 1000565.METUNv1_00483 2.8e-68 221.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,2KVI3@206389|Rhodocyclales 206389|Rhodocyclales S SpoVR family - - - - - - - - - - - - SpoVR k59_322142_1 1000565.METUNv1_00842 2.94e-63 211.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,2KUVE@206389|Rhodocyclales 206389|Rhodocyclales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_322142_2 1000565.METUNv1_00841 9.77e-53 166.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,2KX1E@206389|Rhodocyclales 206389|Rhodocyclales J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_821546_3 1416759.AYMR01000009_gene2996 2.48e-08 55.5 2CK50@1|root,2ZDP0@2|Bacteria,2H0PJ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_429179_1 867902.Ornrh_0947 2.4e-43 145.0 COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,1I24B@117743|Flavobacteriia 976|Bacteroidetes G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_71925_2 1000565.METUNv1_03172 6.28e-103 300.0 COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,2KW9X@206389|Rhodocyclales 206389|Rhodocyclales M shape-determining protein mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_357721_1 1000565.METUNv1_00459 5.76e-88 265.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,2KUN1@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_393374_1 614083.AWQR01000010_gene1598 8.36e-96 293.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,4AA8S@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_36391_1 1122605.KB893645_gene1136 2.69e-129 392.0 COG3525@1|root,COG3525@2|Bacteria,4NH5U@976|Bacteroidetes,1IQ89@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase, family 20, catalytic domain - - - - - - - - - - - - Glyco_hydro_20b k59_786025_1 883126.HMPREF9710_01718 3.65e-47 170.0 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,2VWI6@28216|Betaproteobacteria,475GP@75682|Oxalobacteraceae 28216|Betaproteobacteria G Cyclomaltodextrinase, N-terminal - - - - - - - - - - - - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_464710_1 925409.KI911562_gene376 4.5e-29 113.0 COG0526@1|root,COG0526@2|Bacteria,4NQ06@976|Bacteroidetes,1ISI1@117747|Sphingobacteriia 976|Bacteroidetes O Domain of unknown function (DUF4369) - - - - - - - - - - - - AhpC-TSA,DUF4369 k59_464710_2 1123277.KB893185_gene3065 4.18e-29 115.0 COG3193@1|root,COG3193@2|Bacteria,4NHFF@976|Bacteroidetes,47YE1@768503|Cytophagia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_357731_1 631362.Thi970DRAFT_04896 1.83e-16 84.0 COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2SI@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_1071728_1 1000565.METUNv1_02881 1.35e-220 611.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,2KVIA@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1071728_2 1000565.METUNv1_02880 5.51e-94 283.0 28IJP@1|root,2Z8KI@2|Bacteria,1R9DP@1224|Proteobacteria,2VVJ7@28216|Betaproteobacteria,2KX2H@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1071728_3 1000565.METUNv1_02879 6.48e-41 137.0 COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,2KWWR@206389|Rhodocyclales 206389|Rhodocyclales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_607156_1 159087.Daro_1827 2.04e-18 84.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KU97@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_607156_2 349521.HCH_00195 6.55e-06 48.5 2DN81@1|root,32W0Z@2|Bacteria,1MZF2@1224|Proteobacteria,1S9F7@1236|Gammaproteobacteria,1XKU8@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_785_1 1000565.METUNv1_01007 9.92e-21 85.9 COG4647@1|root,COG4647@2|Bacteria,1N485@1224|Proteobacteria,2VK8X@28216|Betaproteobacteria,2KUTV@206389|Rhodocyclales 206389|Rhodocyclales Q Acetone carboxylase gamma subunit acxC - 6.4.1.6 ko:K10856 - - - - ko00000,ko01000 - - - Acetone_carb_G k59_785_2 159087.Daro_1019 2.02e-59 202.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VI9T@28216|Betaproteobacteria,2KVW2@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase B/oxoprolinase acxB - 6.4.1.6 ko:K10854 - - - - ko00000,ko01000 - - - Hydantoinase_B k59_464724_1 522306.CAP2UW1_2603 3.27e-33 132.0 COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg k59_892992_1 83406.HDN1F_07460 3.22e-103 327.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1J9GS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_107658_1 278957.ABEA03000104_gene277 1.41e-96 299.0 COG0568@1|root,COG0568@2|Bacteria,46S6M@74201|Verrucomicrobia,3K740@414999|Opitutae 414999|Opitutae K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1000054_1 1000565.METUNv1_00302 6.47e-132 383.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,2KUQ4@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_429219_2 1450694.BTS2_3900 4.62e-20 90.5 COG2327@1|root,COG2327@2|Bacteria,1UZDY@1239|Firmicutes,4HQ1I@91061|Bacilli,1ZDY6@1386|Bacillus 91061|Bacilli S Polysaccharide pyruvyl transferase - - - - - - - - - - - - PS_pyruv_trans k59_678705_1 1000565.METUNv1_02237 3.26e-137 390.0 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,2VKP5@28216|Betaproteobacteria 28216|Betaproteobacteria O Glutaredoxin-family domain protein prx5 - - - - - - - - - - - Glutaredoxin,Redoxin k59_500656_1 485918.Cpin_1637 1.89e-42 140.0 COG0361@1|root,COG0361@2|Bacteria,4NS6S@976|Bacteroidetes,1IT95@117747|Sphingobacteriia 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_807_2 1000565.METUNv1_02168 1.65e-49 162.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,2KWHE@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the phosphoglycerate mutase family gpmB - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_179404_1 1000565.METUNv1_01343 5.86e-222 622.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,2KVMP@206389|Rhodocyclales 28216|Betaproteobacteria S sulfide dehydrogenase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - DUF442,FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_714640_1 1163407.UU7_07516 2.04e-90 291.0 COG3587@1|root,COG3587@2|Bacteria,1QUSI@1224|Proteobacteria,1T4KI@1236|Gammaproteobacteria 1236|Gammaproteobacteria V type III restriction enzyme, res subunit - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - ResIII k59_535951_1 1000565.METUNv1_01922 9.57e-74 229.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales 206389|Rhodocyclales T COG0631 Serine threonine protein phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_535951_2 1122919.KB905549_gene1978 3.17e-06 48.5 COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,4HBH3@91061|Bacilli,26RZT@186822|Paenibacillaceae 91061|Bacilli J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C k59_36419_1 748247.AZKH_3162 2.1e-123 367.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria 28216|Betaproteobacteria S cobalamin synthesis protein yjiA_2 - - - - - - - - - - - CobW_C,cobW k59_71961_1 375286.mma_2552 1.42e-36 126.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,474U7@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_429242_1 1000565.METUNv1_00758 7.63e-111 329.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,2KVKZ@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_143456_1 365046.Rta_28890 2.69e-74 249.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,4ABRB@80864|Comamonadaceae 28216|Betaproteobacteria P heavy metal translocating P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_393420_1 1000565.METUNv1_02574 1.58e-199 563.0 arCOG04928@1|root,2Z880@2|Bacteria,1NBNZ@1224|Proteobacteria,2VNGI@28216|Betaproteobacteria 28216|Betaproteobacteria S CRISPR-associated protein Cse1 (CRISPR_cse1) - - - ko:K19123 - - - - ko00000,ko02048 - - - CRISPR_Cse1 k59_393420_2 1000565.METUNv1_02575 4.25e-151 451.0 COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,2VN60@28216|Betaproteobacteria,2KYVB@206389|Rhodocyclales 206389|Rhodocyclales L DEAD-like helicases superfamily - - - - - - - - - - - - - k59_1071782_1 1268622.AVS7_04038 7.32e-69 229.0 COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,2VK2M@28216|Betaproteobacteria,4AAN6@80864|Comamonadaceae 28216|Betaproteobacteria O AAA ATPase, central domain protein - - - - - - - - - - - - AAA k59_1071782_2 243233.MCA1608 3.75e-75 243.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_857140_1 1000565.METUNv1_02370 5.56e-137 392.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2VHZD@28216|Betaproteobacteria,2KV0P@206389|Rhodocyclales 206389|Rhodocyclales C Phosphoribulokinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_179421_1 1000565.METUNv1_00892 3.86e-182 509.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VN0C@28216|Betaproteobacteria,2KXWB@206389|Rhodocyclales 206389|Rhodocyclales D AAA domain - - - - - - - - - - - - - k59_179421_2 1000565.METUNv1_00893 3.96e-60 192.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria 28216|Betaproteobacteria C eight transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_286293_1 1000565.METUNv1_03416 2.11e-93 307.0 COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_322216_1 1000565.METUNv1_00419 0.0 1051.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVEE@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg k59_429257_2 1000565.METUNv1_00675 6e-78 235.0 COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,2KWNA@206389|Rhodocyclales 206389|Rhodocyclales M NLP P60 protein - - - - - - - - - - - - NLPC_P60 k59_214744_1 640081.Dsui_2244 2.12e-16 79.7 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales 206389|Rhodocyclales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_643511_1 351160.RCIX1929 6.94e-18 84.3 COG1817@1|root,arCOG01395@2157|Archaea,2XT3W@28890|Euryarchaeota,2NAFU@224756|Methanomicrobia 224756|Methanomicrobia S Protein of unknown function (DUF354) - - - ko:K09726 - - - - ko00000 - - - DUF354 k59_107697_1 1219031.BBJR01000001_gene616 3.15e-34 131.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,4ABG9@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM NUDIX hydrolase - - - ko:K07455 - - - - ko00000,ko03400 - - - Lactamase_B,NUDIX k59_357798_1 1000565.METUNv1_00115 3.65e-89 291.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales 206389|Rhodocyclales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_357798_2 1163617.SCD_n01459 2.74e-20 85.5 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2VUBZ@28216|Betaproteobacteria 28216|Betaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_36445_1 468059.AUHA01000004_gene2288 2.62e-59 193.0 COG0079@1|root,COG0079@2|Bacteria,4NEDI@976|Bacteroidetes,1IQ0J@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_36445_2 925409.KI911562_gene2911 2.25e-83 259.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,1IQWR@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_750169_1 1000565.METUNv1_00759 1.69e-159 456.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,2KVNI@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_322241_1 1000565.METUNv1_02095 2.85e-34 122.0 COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,2KWU1@206389|Rhodocyclales 206389|Rhodocyclales S signal sequence binding - - - - - - - - - - - - - k59_1036594_2 1121116.KB894766_gene526 4e-18 79.7 COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2VQ1M@28216|Betaproteobacteria,4ADM5@80864|Comamonadaceae 28216|Betaproteobacteria S esterase of the alpha beta - - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase k59_578710_2 1112217.PPL19_04880 1.44e-26 110.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CHASE3,Cache_3-Cache_2,HAMP,MCPsignal k59_657777_1 1265503.KB905176_gene4094 5.46e-19 94.4 COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SKVN@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PilJ k59_443507_1 991905.SL003B_0116 1.45e-81 248.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,4BPHS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Electron transfer flavoprotein etfB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF k59_259944_1 575588.ACPN01000124_gene1917 1.79e-42 157.0 COG1593@1|root,COG1593@2|Bacteria,1PJM6@1224|Proteobacteria,1RPHT@1236|Gammaproteobacteria,3NKX6@468|Moraxellaceae 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1009611_1 640081.Dsui_2434 3.55e-145 428.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,2KVUA@206389|Rhodocyclales 206389|Rhodocyclales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_578718_1 1000565.METUNv1_02231 7.52e-88 271.0 COG1538@1|root,COG1538@2|Bacteria,1PKUI@1224|Proteobacteria,2VMC6@28216|Betaproteobacteria,2KX9S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_220822_1 1157708.KB907459_gene2040 3.66e-88 278.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,4A9KA@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM Ribonuclease II rnb - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_657808_1 700598.Niako_7070 1.85e-64 201.0 COG1143@1|root,COG1143@2|Bacteria,4NI9I@976|Bacteroidetes,1IS7C@117747|Sphingobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_220825_1 1502770.JQMG01000001_gene2373 1.28e-19 92.0 COG2244@1|root,COG2244@2|Bacteria,1RJUT@1224|Proteobacteria,2VWQE@28216|Betaproteobacteria 28216|Betaproteobacteria S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt k59_151606_1 1353529.M899_3449 7.09e-24 99.8 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2MSP3@213481|Bdellovibrionales,2WKEN@28221|Deltaproteobacteria 213481|Bdellovibrionales EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_151606_2 862908.BMS_3380 3.5e-34 120.0 COG1143@1|root,COG1143@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - - - - - - - - - - Fer4,Fer4_7 k59_193198_1 1485544.JQKP01000004_gene502 4.65e-60 195.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,44VHI@713636|Nitrosomonadales 28216|Betaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_115837_1 626887.J057_09836 2.07e-108 331.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,4665Q@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases aidB GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_1009624_1 1000565.METUNv1_00038 1e-99 311.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KUM5@206389|Rhodocyclales 206389|Rhodocyclales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_657823_2 1000565.METUNv1_00389 1.78e-47 155.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2VU0P@28216|Betaproteobacteria,2KWZZ@206389|Rhodocyclales 206389|Rhodocyclales U preprotein translocase secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_193207_1 365046.Rta_10265 4.66e-32 116.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VQTM@28216|Betaproteobacteria,4ADJU@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1044394_1 243233.MCA0585 2.3e-80 254.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,1XE5J@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_865281_1 1000565.METUNv1_00694 8.69e-139 401.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,2KU6U@206389|Rhodocyclales 206389|Rhodocyclales P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_259974_1 1123487.KB892846_gene631 2.79e-64 223.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KV6Z@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_115845_2 1000565.METUNv1_00759 6.45e-102 306.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,2KVNI@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1044405_1 595537.Varpa_4649 3.54e-68 218.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,4AAWG@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family urtC - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_543594_1 1000565.METUNv1_03861 1.43e-117 340.0 COG0819@1|root,COG0819@2|Bacteria,1MVA0@1224|Proteobacteria,2WGSW@28216|Betaproteobacteria,2KVR3@206389|Rhodocyclales 206389|Rhodocyclales K Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_657871_1 159087.Daro_3395 3.06e-61 196.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,2KUGF@206389|Rhodocyclales 206389|Rhodocyclales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1009663_1 1504672.669783820 4.43e-103 313.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,4ABQ5@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1114166_1 211165.AJLN01000100_gene4336 4.67e-10 59.7 COG3250@1|root,COG3250@2|Bacteria,1G27N@1117|Cyanobacteria,1JKTI@1189|Stigonemataceae 1117|Cyanobacteria G Glycosyl hydrolases family 2, sugar binding domain - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1114166_2 1123499.KB908020_gene816 2.73e-27 110.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2VHT2@28216|Betaproteobacteria,2KPDQ@206351|Neisseriales 206351|Neisseriales C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_1044413_1 257313.BP2973 1.02e-105 320.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,3T1WZ@506|Alcaligenaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family dbpA GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_473752_1 1121033.AUCF01000004_gene4645 4.59e-46 153.0 COG1596@1|root,COG1596@2|Bacteria,1MXYS@1224|Proteobacteria,2U93S@28211|Alphaproteobacteria,2JSGB@204441|Rhodospirillales 204441|Rhodospirillales M COG1596 Periplasmic protein involved in polysaccharide export - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_115879_1 29581.BW37_03956 8.78e-70 225.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,476AR@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_795551_1 643867.Ftrac_0935 1.55e-58 204.0 COG1181@1|root,COG1181@2|Bacteria,4NE9P@976|Bacteroidetes,47M8U@768503|Cytophagia 976|Bacteroidetes F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_657903_1 1437824.BN940_03931 7.59e-51 175.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,3T2BB@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_260018_1 748247.AZKH_3592 2.73e-16 78.2 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2VN03@28216|Betaproteobacteria,2KV9N@206389|Rhodocyclales 206389|Rhodocyclales S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3,Polysacc_synt_C k59_865334_1 316067.Geob_0648 8.83e-31 124.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,42PJA@68525|delta/epsilon subdivisions,2WMG0@28221|Deltaproteobacteria,43TUT@69541|Desulfuromonadales 28221|Deltaproteobacteria O repeat-containing protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8 k59_971602_1 643562.Daes_0344 9.66e-15 80.1 COG2199@1|root,COG5001@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21084 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3,dCache_1 k59_1009684_1 1156919.QWC_18067 2.36e-155 446.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,3T30A@506|Alcaligenaceae 28216|Betaproteobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_443662_1 1349767.GJA_517 4.24e-15 72.8 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,2WI1V@28216|Betaproteobacteria,478SY@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Pilin (bacterial filament) - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_1086251_1 1304877.KI519399_gene4136 2.77e-135 396.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria 1224|Proteobacteria S permease yraQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_296655_1 1121087.AUCK01000020_gene2111 2.02e-30 122.0 COG0001@1|root,COG0001@2|Bacteria,1TRD7@1239|Firmicutes,4HA12@91061|Bacilli,1ZCDI@1386|Bacillus 91061|Bacilli H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_473781_1 765912.Thimo_3413 1.95e-84 282.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,1RNHM@1236|Gammaproteobacteria,1WW54@135613|Chromatiales 135613|Chromatiales L PFAM DNA methylase - - 2.1.1.72 ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_151704_1 640081.Dsui_1554 1.28e-106 338.0 COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_935924_1 622637.KE124774_gene3788 5.11e-30 120.0 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2TSZA@28211|Alphaproteobacteria,36ZE5@31993|Methylocystaceae 28211|Alphaproteobacteria M HlyD family secretion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_578811_1 1000565.METUNv1_03671 1.08e-85 288.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_115933_2 1198452.Jab_2c17720 4.48e-07 57.0 2DNTV@1|root,32Z41@2|Bacteria,1QUYK@1224|Proteobacteria,2W3H7@28216|Betaproteobacteria,4791F@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF642) - - - - - - - - - - - - DUF642,VPEP k59_81001_2 985255.APHJ01000016_gene2943 3.53e-54 174.0 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k59_367539_1 1304883.KI912532_gene482 1.06e-96 314.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KUZA@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_443733_1 397945.Aave_1860 4.45e-108 323.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,4AAHX@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_193388_1 1132836.RCCGE510_11749 0.000833 43.5 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2TVNU@28211|Alphaproteobacteria,4B7T5@82115|Rhizobiaceae 28211|Alphaproteobacteria M Male sterility protein - - 5.1.3.2,5.1.3.26 ko:K01784,ko:K19997 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_193388_2 589865.DaAHT2_1766 0.000336 46.6 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,42TSF@68525|delta/epsilon subdivisions,2X5F6@28221|Deltaproteobacteria,2MM40@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_473808_1 1538295.JY96_17215 1.15e-10 61.6 COG0784@1|root,COG4585@1|root,COG0784@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,1KJJ7@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Response regulator receiver - - - - - - - - - - - - HATPase_c,HisKA_3,PAS_3,PAS_9,Response_reg k59_473808_2 1265502.KB905929_gene2137 1.45e-109 319.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,4AAF7@80864|Comamonadaceae 28216|Betaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg k59_1009730_1 365044.Pnap_3015 5.19e-58 189.0 28HGQ@1|root,2Z7SH@2|Bacteria,1R6PH@1224|Proteobacteria,2VK2P@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1009730_2 365044.Pnap_3014 1.63e-07 52.4 2C958@1|root,304UC@2|Bacteria,1REZP@1224|Proteobacteria,2VRJQ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_543691_1 1000565.METUNv1_02820 2.84e-65 201.0 COG0454@1|root,COG0456@2|Bacteria,1N7JM@1224|Proteobacteria,2VU1F@28216|Betaproteobacteria,2KX24@206389|Rhodocyclales 206389|Rhodocyclales K Protein of unknown function (DUF3579) - - - - - - - - - - - - DUF3579 k59_658030_1 1123393.KB891330_gene788 5.79e-101 302.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VQAV@28216|Betaproteobacteria,1KSQ0@119069|Hydrogenophilales 119069|Hydrogenophilales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_543692_1 1000565.METUNv1_00442 1.32e-135 395.0 2CG46@1|root,2Z7W3@2|Bacteria,1NFW3@1224|Proteobacteria,2VN3X@28216|Betaproteobacteria,2KVGK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1086341_1 640081.Dsui_0183 7.89e-51 167.0 COG1974@1|root,COG1974@2|Bacteria,1PE1D@1224|Proteobacteria,2WAQI@28216|Betaproteobacteria,2KZGS@206389|Rhodocyclales 206389|Rhodocyclales K Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_722891_2 614083.AWQR01000009_gene687 1.54e-58 189.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,4ACWB@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase pleD - - - - - - - - - - - GGDEF,Response_reg,SBP_bac_3 k59_516718_2 1415779.JOMH01000001_gene2622 7.56e-42 147.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1X8WG@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Radical_SAM k59_1010847_1 84531.JMTZ01000030_gene197 1.05e-91 280.0 COG4447@1|root,COG4447@2|Bacteria,1R9D5@1224|Proteobacteria 1224|Proteobacteria S cellulose binding - - - - - - - - - - - - - k59_797098_1 614083.AWQR01000038_gene1417 0.000364 43.9 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,4ABX3@80864|Comamonadaceae 28216|Betaproteobacteria OU peptidase S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_797098_2 614083.AWQR01000038_gene1418 5.13e-71 215.0 COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,4AER9@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Rieske 2Fe-2S domain protein - - - - - - - - - - - - Rieske k59_46899_1 1000565.METUNv1_00077 8.66e-109 323.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KUFP@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_10477_1 1000565.METUNv1_03764 1.38e-140 409.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,2KVCF@206389|Rhodocyclales 206389|Rhodocyclales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_221962_1 1000565.METUNv1_01855 1.02e-118 357.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUPC@206389|Rhodocyclales 206389|Rhodocyclales T COG2202 FOG PAS PAC domain - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_82225_2 1000565.METUNv1_02754 2.9e-84 254.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2VQ64@28216|Betaproteobacteria,2KW6G@206389|Rhodocyclales 206389|Rhodocyclales N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_117119_1 614083.AWQR01000035_gene3619 1.6e-45 157.0 COG3616@1|root,COG3616@2|Bacteria,1MXV3@1224|Proteobacteria,2VIPE@28216|Betaproteobacteria,4AGQM@80864|Comamonadaceae 28216|Betaproteobacteria E Alanine racemase, N-terminal domain - - - - - - - - - - - - Ala_racemase_N k59_117119_2 614083.AWQR01000051_gene3445 1.49e-42 154.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,4A9KW@80864|Comamonadaceae 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_516750_1 1000565.METUNv1_00579 1.2e-122 355.0 COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,2VK09@28216|Betaproteobacteria,2KZYB@206389|Rhodocyclales 28216|Betaproteobacteria H Methylene-tetrahydromethanopterin dehydrogenase, N-terminal - - - - - - - - - - - - Mpt_N k59_46923_1 375286.mma_0651 6.73e-60 194.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2VM8Y@28216|Betaproteobacteria,4727P@75682|Oxalobacteraceae 28216|Betaproteobacteria K Transcriptional regulator ilvR - - - - - - - - - - - HTH_1,LysR_substrate k59_261398_1 365044.Pnap_0997 9.06e-109 323.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_1126334_1 748247.AZKH_0193 6e-82 272.0 COG0784@1|root,COG2197@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2197@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,2KZWN@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_558435_2 395495.Lcho_1158 1.63e-117 342.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,2VK51@28216|Betaproteobacteria,1KN6J@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Pfam:DUF694 - - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_589631_1 1101195.Meth11DRAFT_0818 6.72e-36 131.0 COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,2W84F@28216|Betaproteobacteria,2KNX5@206350|Nitrosomonadales 206350|Nitrosomonadales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_312342_1 382464.ABSI01000010_gene3445 7.36e-25 107.0 COG1185@1|root,COG1185@2|Bacteria,46SBP@74201|Verrucomicrobia,2ITWE@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_984315_1 1115632.JAFW01000001_gene4421 1.13e-22 102.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,1WCH3@1268|Micrococcaceae 201174|Actinobacteria Q Peptide synthetase - - 6.3.2.14 ko:K02364 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_914254_1 748247.AZKH_3577 1.4e-127 379.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,2KV0F@206389|Rhodocyclales 206389|Rhodocyclales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_212899_1 1121033.AUCF01000003_gene3378 4.7e-94 284.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TSKV@28211|Alphaproteobacteria,2JQZM@204441|Rhodospirillales 204441|Rhodospirillales C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_558469_1 614083.AWQR01000030_gene2724 5.73e-158 461.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,4AA4F@80864|Comamonadaceae 28216|Betaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_488479_1 365044.Pnap_2715 7.59e-98 289.0 COG0411@1|root,COG0411@2|Bacteria,1R6NR@1224|Proteobacteria,2VKT2@28216|Betaproteobacteria,4A9ZC@80864|Comamonadaceae 28216|Betaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_809051_1 1122243.KB903771_gene1539 2.23e-40 142.0 COG0863@1|root,COG0863@2|Bacteria,1NXST@1224|Proteobacteria,1T4SE@1236|Gammaproteobacteria,3NTST@468|Moraxellaceae 1236|Gammaproteobacteria L DNA methylase - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_165347_1 1198452.Jab_2c24790 2.39e-59 194.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,47397@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family pbpG - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_165347_2 1198452.Jab_2c24800 1.41e-16 76.6 COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2VKIZ@28216|Betaproteobacteria,4749Q@75682|Oxalobacteraceae 28216|Betaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_94002_1 1408813.AYMG01000031_gene1489 4.28e-107 322.0 COG4299@1|root,COG4299@2|Bacteria,4NGKU@976|Bacteroidetes,1IQII@117747|Sphingobacteriia 976|Bacteroidetes S COGs COG4299 conserved - - - - - - - - - - - - DUF5009 k59_129275_1 1166948.JPZL01000002_gene1258 1.92e-52 187.0 COG4643@1|root,COG5545@1|root,COG4643@2|Bacteria,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,1S6W2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Virulence-associated protein - - - ko:K06919 - - - - ko00000 - - - Prim-Pol,Toprim_3,Toprim_4,VirE k59_212945_2 1000565.METUNv1_02485 8.16e-62 197.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,2KVY8@206389|Rhodocyclales 206389|Rhodocyclales S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Rrf2,Virul_fac_BrkB k59_914277_2 640081.Dsui_0476 1.58e-55 179.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,2KUF1@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1063434_1 1000565.METUNv1_03031 6.18e-31 119.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2VKTE@28216|Betaproteobacteria,2KXVP@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GGDEF k59_312408_1 983544.Lacal_2376 1.07e-24 96.7 COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,1I16V@117743|Flavobacteriia 976|Bacteroidetes O Thiol peroxidase bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_312408_2 240016.ABIZ01000001_gene2722 1.13e-46 153.0 COG0450@1|root,COG0450@2|Bacteria,46STI@74201|Verrucomicrobia,2IUMB@203494|Verrucomicrobiae 203494|Verrucomicrobiae O Redoxin - - - - - - - - - - - - AhpC-TSA k59_699029_1 765698.Mesci_3835 6.06e-38 142.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria 1224|Proteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_735355_1 1267534.KB906754_gene3883 1.12e-16 84.7 COG4409@1|root,COG4409@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia 204432|Acidobacteriia G Belongs to the peptidase S8 family - - - - - - - - - - - - ASH,DUF1573 k59_212984_1 1000565.METUNv1_02486 1.16e-64 213.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,2VSM7@28216|Betaproteobacteria,2KWS4@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_699043_1 596154.Alide2_4136 1.75e-42 145.0 COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,2VKZD@28216|Betaproteobacteria,4A9QV@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Exonuclease, RNase T and DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_699043_2 1121116.KB894768_gene2012 8.58e-28 113.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,4AC6C@80864|Comamonadaceae 28216|Betaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_413778_1 1000565.METUNv1_03639 6.48e-119 346.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,2KVU0@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_488554_1 948106.AWZT01000009_gene2741 1.36e-55 186.0 COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,2VN1F@28216|Betaproteobacteria,1K0E3@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM major facilitator superfamily MFS_1 fsr - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1 k59_213008_1 572480.Arnit_2891 2.57e-10 66.6 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2YMEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7 k59_213008_2 1124983.PFLCHA0_c06830 2.98e-13 67.4 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1YPGV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0560 DHquinase_II k59_1022855_1 1523503.JPMY01000016_gene709 1.54e-18 89.7 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria 1236|Gammaproteobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_232164_1 1198452.Jab_2c04450 1.51e-19 82.4 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,4749V@75682|Oxalobacteraceae 28216|Betaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_735383_1 1278073.MYSTI_03593 4.85e-23 103.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions 1224|Proteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_232173_1 1000565.METUNv1_02564 2.4e-220 611.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VK20@28216|Betaproteobacteria,2KZT3@206389|Rhodocyclales 206389|Rhodocyclales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_946847_1 887062.HGR_13994 7.1e-09 56.2 COG3181@1|root,COG3181@2|Bacteria,1N00G@1224|Proteobacteria,2VN46@28216|Betaproteobacteria,4ABNY@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_946847_2 946483.Cenrod_1780 2.58e-44 148.0 COG0745@1|root,COG0745@2|Bacteria,1NKXE@1224|Proteobacteria,2WI6Z@28216|Betaproteobacteria 28216|Betaproteobacteria KT cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_165436_1 1123269.NX02_14425 1.84e-84 267.0 COG1235@1|root,COG2203@1|root,COG1235@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2TVMC@28211|Alphaproteobacteria,2K2VD@204457|Sphingomonadales 204457|Sphingomonadales T HWE histidine kinase - - - - - - - - - - - - GAF,HWE_HK,PAS_3 k59_165436_2 269799.Gmet_3527 2.48e-16 78.2 COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria,43W1E@69541|Desulfuromonadales 28221|Deltaproteobacteria L zinc-finger of transposase IS204/IS1001/IS1096/IS1165 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_129378_1 1144342.PMI40_00078 2.68e-20 94.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria,475VB@75682|Oxalobacteraceae 28216|Betaproteobacteria NT methyl-accepting chemotaxis - - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,NIT k59_129378_2 1349767.GJA_3554 3.51e-09 55.8 COG0745@1|root,COG0745@2|Bacteria,1RB68@1224|Proteobacteria,2VQS9@28216|Betaproteobacteria,473IC@75682|Oxalobacteraceae 28216|Betaproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K07774 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_558603_1 1046714.AMRX01000008_gene1055 2.53e-23 99.8 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RMZB@1236|Gammaproteobacteria,465YB@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_845052_1 614083.AWQR01000022_gene77 5.73e-112 327.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VIYH@28216|Betaproteobacteria,4AAXH@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_845052_2 543728.Vapar_0073 1.4e-25 103.0 COG3181@1|root,COG3181@2|Bacteria,1Q5FF@1224|Proteobacteria,2VIJ9@28216|Betaproteobacteria,4AAY7@80864|Comamonadaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_558616_1 1000565.METUNv1_00867 1.23e-101 318.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUQZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_383388_3 1000565.METUNv1_00574 2.24e-05 46.6 COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,2KWKU@206389|Rhodocyclales 206389|Rhodocyclales S secreted protein - - - - - - - - - - - - SIMPL k59_1126527_1 596154.Alide2_0044 3.09e-97 310.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,4A9VI@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_165483_2 1000565.METUNv1_00812 1.29e-74 231.0 COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VK7S@28216|Betaproteobacteria,2KUTS@206389|Rhodocyclales 206389|Rhodocyclales H Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_213160_1 929556.Solca_0236 3.96e-29 107.0 COG0526@1|root,COG0526@2|Bacteria,4NQ6I@976|Bacteroidetes,1IT9N@117747|Sphingobacteriia 976|Bacteroidetes CO Thioredoxin trxA_1 - - - - - - - - - - - Thioredoxin k59_165498_1 1120792.JAFV01000001_gene3026 7.49e-24 105.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,36XII@31993|Methylocystaceae 28211|Alphaproteobacteria E Bacterial NAD-glutamate dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_984519_2 864051.BurJ1DRAFT_4193 3.46e-13 72.0 COG3292@1|root,COG3292@2|Bacteria,1QU1S@1224|Proteobacteria,2VPDV@28216|Betaproteobacteria,1KMX9@119065|unclassified Burkholderiales 28216|Betaproteobacteria T PFAM Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_58791_1 1230338.MOMA_04445 1.22e-40 155.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,3NKMC@468|Moraxellaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_1022989_1 1122951.ATUE01000005_gene2247 2.38e-30 113.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,3NIUK@468|Moraxellaceae 1236|Gammaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_1022989_2 1122951.ATUE01000005_gene2248 1.09e-40 144.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,3NJ39@468|Moraxellaceae 1236|Gammaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_22494_1 477184.KYC_22446 7.86e-75 236.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,2VI6Y@28216|Betaproteobacteria,3T62G@506|Alcaligenaceae 28216|Betaproteobacteria I Phosphate acyltransferases yihG - - - - - - - - - - - Acyltransferase k59_879641_1 1276756.AUEX01000044_gene2625 1.03e-88 287.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_984544_1 339670.Bamb_4066 3.26e-44 153.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJHD@28216|Betaproteobacteria,1K4QY@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_984544_2 935567.JAES01000012_gene929 5.93e-05 44.7 COG0583@1|root,COG0583@2|Bacteria,1R7X2@1224|Proteobacteria,1RZVD@1236|Gammaproteobacteria,1XCR9@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_232263_1 1207076.ALAT01000187_gene2854 3.2e-63 202.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1Z01N@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_768718_1 1198452.Jab_1c06310 4.22e-63 198.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,472WA@75682|Oxalobacteraceae 28216|Betaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_768718_2 1005048.CFU_0387 3.78e-44 147.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,474JH@75682|Oxalobacteraceae 28216|Betaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_623239_1 248742.XP_005645178.1 4.22e-38 146.0 COG0013@1|root,COG0625@1|root,KOG0188@2759|Eukaryota,KOG0867@2759|Eukaryota,37Q0V@33090|Viridiplantae,34H1W@3041|Chlorophyta 3041|Chlorophyta J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain - - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,GST_C,GST_N,tRNA-synt_2c,tRNA_SAD k59_986482_1 195253.Syn6312_2622 9.21e-58 195.0 COG4941@1|root,COG4941@2|Bacteria,1G1YQ@1117|Cyanobacteria 1117|Cyanobacteria K RNA polymerase sigma factor containing a TPR repeat domain - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2 k59_701143_1 1068980.ARVW01000001_gene6764 4.66e-39 143.0 COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria,4E0ZZ@85010|Pseudonocardiales 201174|Actinobacteria I PFAM Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1025034_2 883126.HMPREF9710_01749 2.48e-18 80.9 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,474U2@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome c nirM - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_1096953_1 1268622.AVS7_02015 8.45e-71 227.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,4AB30@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1096953_2 338969.Rfer_1933 2.31e-27 107.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4A9QA@80864|Comamonadaceae 28216|Betaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_60544_1 614083.AWQR01000009_gene512 1.32e-205 571.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,4AA16@80864|Comamonadaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_737186_1 1031711.RSPO_c02946 3.17e-32 123.0 COG0395@1|root,COG0395@2|Bacteria,1REG1@1224|Proteobacteria,2VNIN@28216|Betaproteobacteria,1K32H@119060|Burkholderiaceae 28216|Betaproteobacteria G K channel, inward rectifier, conserved region 2 domain protein - - - ko:K08715 - - - - ko00000,ko02000 1.A.2.2 - - IRK k59_60557_1 1122951.ATUE01000007_gene690 2.03e-190 540.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria,3NN1R@468|Moraxellaceae 1236|Gammaproteobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - Abhydrolase_3,FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_3 k59_701177_1 1121033.AUCF01000015_gene1503 4.52e-84 268.0 COG5434@1|root,COG5434@2|Bacteria,1R7M4@1224|Proteobacteria,2U4CX@28211|Alphaproteobacteria,2JZM9@204441|Rhodospirillales 204441|Rhodospirillales M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_167480_1 399795.CtesDRAFT_PD4963 1.75e-66 211.0 COG0745@1|root,COG0745@2|Bacteria,1MVQT@1224|Proteobacteria,2VKJH@28216|Betaproteobacteria,4ACSG@80864|Comamonadaceae 28216|Betaproteobacteria K Two component transcriptional regulator, winged - - - - - - - - - - - - Response_reg,Trans_reg_C k59_701183_1 1122963.AUHB01000017_gene1965 2.26e-108 321.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria,371AT@31993|Methylocystaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP k59_386141_1 1166018.FAES_1278 3.7e-91 295.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,47JHW@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1025086_1 365046.Rta_20950 2.21e-103 330.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,4A9TX@80864|Comamonadaceae 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_897617_1 296591.Bpro_4166 5.3e-88 269.0 COG0226@1|root,COG0226@2|Bacteria,1QX6C@1224|Proteobacteria,2VN6X@28216|Betaproteobacteria,4AGFF@80864|Comamonadaceae 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_506661_1 159087.Daro_3390 8.03e-39 134.0 COG3090@1|root,COG3090@2|Bacteria,1RDY3@1224|Proteobacteria,2VRWQ@28216|Betaproteobacteria,2KX32@206389|Rhodocyclales 206389|Rhodocyclales G TRAP-type C4-dicarboxylate transport system, small permease component - - - - - - - - - - - - DctQ k59_506661_2 159087.Daro_3391 1.85e-24 100.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VIJ6@28216|Betaproteobacteria,2KUIW@206389|Rhodocyclales 206389|Rhodocyclales G transporter - - - - - - - - - - - - DctP k59_1003983_1 1000565.METUNv1_00842 4.29e-166 483.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,2KUVE@206389|Rhodocyclales 206389|Rhodocyclales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_790382_1 1000565.METUNv1_03512 5.9e-138 409.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,2KVJZ@206389|Rhodocyclales 206389|Rhodocyclales I carboxylase pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_574872_1 375286.mma_2759 1.24e-34 120.0 29U1D@1|root,30FAK@2|Bacteria,1RCY2@1224|Proteobacteria,2VSA6@28216|Betaproteobacteria 28216|Betaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_574872_2 795666.MW7_1004 2.55e-40 134.0 2E1U6@1|root,30XF4@2|Bacteria,1P32B@1224|Proteobacteria,2W4V6@28216|Betaproteobacteria,1KF5I@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_574872_3 375286.mma_2757 1.23e-59 194.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2VKJR@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM DNA methylase N-4 N-6 - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_40954_1 1000565.METUNv1_01293 2.46e-197 558.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,2KV3Y@206389|Rhodocyclales 206389|Rhodocyclales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_753478_1 1122951.ATUE01000005_gene2231 2.17e-26 108.0 COG1593@1|root,COG1593@2|Bacteria,1PJM6@1224|Proteobacteria,1RPHT@1236|Gammaproteobacteria,3NKX6@468|Moraxellaceae 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_649602_1 614083.AWQR01000014_gene2424 1.64e-112 332.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,4A9QQ@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM acetylornithine and succinylornithine argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_255034_1 1000565.METUNv1_01302 0.0 884.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KV4M@206389|Rhodocyclales 206389|Rhodocyclales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1040349_1 1198452.Jab_1c03560 7.33e-92 273.0 COG3145@1|root,COG3145@2|Bacteria,1RGXU@1224|Proteobacteria,2VRN1@28216|Betaproteobacteria,47768@75682|Oxalobacteraceae 28216|Betaproteobacteria L 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_2 k59_897640_1 365046.Rta_23360 2.74e-27 115.0 COG0784@1|root,COG3614@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3614@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,4AJX3@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg k59_185297_1 395495.Lcho_1248 1.24e-140 409.0 COG0415@1|root,COG0415@2|Bacteria,1MX6J@1224|Proteobacteria,2VK7R@28216|Betaproteobacteria,1KNC4@119065|unclassified Burkholderiales 28216|Betaproteobacteria H DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_435308_1 398578.Daci_3362 2.68e-48 163.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VIE7@28216|Betaproteobacteria,4AAQT@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Alcohol dehydrogenase zinc-binding domain protein - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_435308_2 614083.AWQR01000018_gene1728 2.67e-31 113.0 COG2050@1|root,COG2050@2|Bacteria,1MYG1@1224|Proteobacteria,2VTQD@28216|Betaproteobacteria,4ADXA@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM thioesterase superfamily protein - - - - - - - - - - - - 4HBT k59_1040355_1 1458275.AZ34_05965 1.2e-84 275.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,4A9NS@80864|Comamonadaceae 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_468916_1 7091.BGIBMGA005089-TA 0.000233 42.7 COG0740@1|root,KOG0840@2759|Eukaryota,38PE0@33154|Opisthokonta,3BEPT@33208|Metazoa,3CVZ0@33213|Bilateria,41UZT@6656|Arthropoda,3SFTD@50557|Insecta,449MH@7088|Lepidoptera 33208|Metazoa O Clp protease CLPP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009368,GO:0009987,GO:0010033,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022607,GO:0030163,GO:0031974,GO:0032991,GO:0033554,GO:0034514,GO:0034620,GO:0035966,GO:0035967,GO:0042221,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051259,GO:0051260,GO:0051603,GO:0051716,GO:0065003,GO:0070011,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_468916_2 1000565.METUNv1_00035 8.44e-235 654.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KU9B@206389|Rhodocyclales 206389|Rhodocyclales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1004005_1 716928.AJQT01000005_gene3725 1.3e-96 287.0 COG0625@1|root,COG0625@2|Bacteria,1PENB@1224|Proteobacteria,2TRVC@28211|Alphaproteobacteria,4B9TK@82115|Rhizobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_649627_1 240015.ACP_1689 2.92e-17 90.1 COG1835@1|root,COG1835@2|Bacteria,3Y3FZ@57723|Acidobacteria,2JIU7@204432|Acidobacteriia 204432|Acidobacteriia I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_1004009_1 382245.ASA_4302 4.69e-93 281.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1Y464@135624|Aeromonadales 135624|Aeromonadales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1040363_1 697282.Mettu_3981 1.28e-62 202.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RPR0@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_4 k59_539460_1 1123037.AUDE01000011_gene917 3.9e-09 60.1 29E11@1|root,32C2C@2|Bacteria,4P5ZC@976|Bacteroidetes,1IA6H@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_398219_1 1198452.Jab_1c05150 3.95e-98 295.0 COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2VNYQ@28216|Betaproteobacteria,475JC@75682|Oxalobacteraceae 28216|Betaproteobacteria D Cellulose biosynthesis protein BcsQ cpaE1 - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,Response_reg k59_398219_2 1198452.Jab_1c05160 1.73e-28 112.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,475QS@75682|Oxalobacteraceae 28216|Betaproteobacteria U Type II/IV secretion system protein cpaF1 - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_897661_1 557598.LHK_01703 1.2e-11 64.7 COG3187@1|root,COG3187@2|Bacteria,1NGG1@1224|Proteobacteria,2VXHK@28216|Betaproteobacteria,2KS8H@206351|Neisseriales 206351|Neisseriales O META domain - - - - - - - - - - - - META k59_897661_2 279714.FuraDRAFT_3774 6.77e-05 43.9 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,2KQFK@206351|Neisseriales 206351|Neisseriales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_146781_1 1000565.METUNv1_02278 8.69e-29 104.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,2KWAI@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_897672_1 1408418.JNJH01000002_gene2752 4.16e-14 77.8 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0457 FOG TPR repeat - - - - - - - - - - - - Glyco_transf_9,TPR_11,TPR_16,TPR_2,TPR_8 k59_1110396_1 543728.Vapar_5090 9.15e-42 153.0 COG1506@1|root,COG1506@2|Bacteria,1R06E@1224|Proteobacteria,2WHTF@28216|Betaproteobacteria,4AK3A@80864|Comamonadaceae 28216|Betaproteobacteria E Secretory lipase - - - - - - - - - - - - LIP,Peptidase_S9 k59_897673_1 395494.Galf_0744 6.3e-37 135.0 COG0551@1|root,COG0551@2|Bacteria,1R81P@1224|Proteobacteria,2VV8R@28216|Betaproteobacteria 28216|Betaproteobacteria L Nuclease-related domain - - - - - - - - - - - - NERD k59_398232_1 1000565.METUNv1_02790 2.69e-184 530.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,2KU6I@206389|Rhodocyclales 206389|Rhodocyclales E extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_40998_1 420662.Mpe_A2809 8.85e-62 207.0 COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,1KMWB@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Formyl transferase hoxX - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N k59_1078055_1 1408164.MOLA814_00545 2.28e-64 198.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2VSD7@28216|Betaproteobacteria,1KQZX@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_398246_1 580332.Slit_0611 2.65e-81 248.0 COG1216@1|root,COG1216@2|Bacteria,1RG89@1224|Proteobacteria,2VS9G@28216|Betaproteobacteria 28216|Betaproteobacteria S Glycosyltransferase like family - - - - - - - - - - - - Glyco_tranf_2_5 k59_398246_2 1198452.Jab_2c09530 1.06e-13 70.5 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria,478GF@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1110398_1 1000565.METUNv1_01638 3.02e-128 369.0 29TFP@1|root,30ENV@2|Bacteria,1RG86@1224|Proteobacteria,2VS6R@28216|Betaproteobacteria,2KWFR@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1110398_2 864051.BurJ1DRAFT_1174 1.11e-91 278.0 2EMF3@1|root,2ZKNW@2|Bacteria,1RAZA@1224|Proteobacteria,2VQE2@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_362156_1 420662.Mpe_A3394 8.05e-37 130.0 COG2010@1|root,COG2010@2|Bacteria,1RG8M@1224|Proteobacteria,2VS50@28216|Betaproteobacteria,1KKX0@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_185373_1 1177928.TH2_17116 1.52e-61 207.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2U0PD@28211|Alphaproteobacteria,2JPZE@204441|Rhodospirillales 204441|Rhodospirillales T HD domain - - - - - - - - - - - - GAF,GAF_2,HD_5 k59_291094_1 296591.Bpro_3665 1.34e-104 328.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,4A9YM@80864|Comamonadaceae 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_41010_1 1500897.JQNA01000002_gene1507 2.84e-05 51.6 COG0642@1|root,COG1352@1|root,COG4566@1|root,COG1352@2|Bacteria,COG2205@2|Bacteria,COG4566@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae 28216|Betaproteobacteria T catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - - - - - - - - - - CheR,CheR_N,DUF4118,GerE,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_399512_1 1121447.JONL01000004_gene2887 2.11e-11 64.3 COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2M80U@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9 k59_399512_2 748247.AZKH_2215 1.12e-30 121.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VPRI@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_540387_10 323848.Nmul_A1364 1.88e-34 126.0 COG0741@1|root,COG0741@2|Bacteria,1Q0FH@1224|Proteobacteria,2W58U@28216|Betaproteobacteria 28216|Betaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_540387_17 1000565.METUNv1_01215 6.07e-131 378.0 28JV9@1|root,2Z9K8@2|Bacteria,1MVTX@1224|Proteobacteria,2VP25@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_540387_19 1000565.METUNv1_01213 2.29e-45 157.0 COG0433@1|root,COG0433@2|Bacteria,1N2WU@1224|Proteobacteria,2VUFK@28216|Betaproteobacteria 28216|Betaproteobacteria S COG0433 Predicted ATPase - - - - - - - - - - - - - k59_540387_21 1218075.BAYA01000017_gene4692 8.88e-160 479.0 28HIF@1|root,2Z7TX@2|Bacteria,1MY24@1224|Proteobacteria,2VM3H@28216|Betaproteobacteria,1K5U9@119060|Burkholderiaceae 28216|Betaproteobacteria S Bacteriophage replication gene A protein (GPA) - - - - - - - - - - - - Phage_GPA k59_470103_1 614083.AWQR01000046_gene3315 1.67e-11 64.7 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,2VM4I@28216|Betaproteobacteria,4AAE6@80864|Comamonadaceae 28216|Betaproteobacteria N TIGRFAM Flagellar hook-associated protein 3 flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_218312_2 1000565.METUNv1_02414 2.38e-141 419.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria,2KUZ5@206389|Rhodocyclales 206389|Rhodocyclales NU Type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N_2 k59_827279_1 1000565.METUNv1_00582 1.5e-139 404.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,2KUDA@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - - - - - - - - - - - SHMT k59_827279_2 1000565.METUNv1_00581 1.57e-22 94.7 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria 28216|Betaproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_791565_1 398527.Bphyt_0269 6.97e-64 210.0 COG4974@1|root,COG4974@2|Bacteria,1RBMG@1224|Proteobacteria,2VM96@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_932736_1 10116.ENSRNOP00000049769 9.17e-142 402.0 COG0356@1|root,KOG4665@2759|Eukaryota,38D9B@33154|Opisthokonta,3BS30@33208|Metazoa,3E4C3@33213|Bilateria,48R1H@7711|Chordata,49MMI@7742|Vertebrata,3JNI3@40674|Mammalia,35UCR@314146|Euarchontoglires,4Q8HA@9989|Rodentia 33208|Metazoa C Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel ATP6 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0006950,GO:0007568,GO:0008150,GO:0009628,GO:0016020,GO:0016469,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032502,GO:0032991,GO:0036296,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045259,GO:0050896,GO:0055093,GO:0070482,GO:0098796,GO:0098798,GO:0098800 - ko:K02126 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002,ko03029 3.A.2.1 - - ATP-synt_A k59_540409_1 1000565.METUNv1_02847 3.87e-100 305.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,2KVHU@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1005653_1 1565314.OA34_03015 1.41e-43 159.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_575816_2 1000565.METUNv1_00104 1.28e-74 228.0 COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2VQ0B@28216|Betaproteobacteria,2KYS1@206389|Rhodocyclales 206389|Rhodocyclales O Redoxin - - - - - - - - - - - - Redoxin k59_1041637_1 1458275.AZ34_06385 2.46e-108 338.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,4A9KW@80864|Comamonadaceae 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_77585_1 1123487.KB892865_gene1550 5.82e-93 273.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,2KW9N@206389|Rhodocyclales 206389|Rhodocyclales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_470142_2 1168289.AJKI01000004_gene2954 1.37e-25 102.0 2DRX2@1|root,33DGD@2|Bacteria,4NY6I@976|Bacteroidetes,2FVFY@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_5622_1 91604.ID47_03280 8.25e-37 134.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,47EYG@766|Rickettsiales 766|Rickettsiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_5622_3 337075.U4LL10 1.67e-38 149.0 COG1034@1|root,KOG2282@2759|Eukaryota,38DHR@33154|Opisthokonta,3NW5Z@4751|Fungi,3QJRY@4890|Ascomycota 4751|Fungi C Belongs to the complex I 75 kDa subunit family NdufS1 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0048037,GO:0050136,GO:0051536,GO:0051540,GO:0055114,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K03934 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1.6 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C k59_187300_1 546267.NEIPOLOT_01958 3.02e-41 148.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,2KQFJ@206351|Neisseriales 206351|Neisseriales M 3-deoxy-D-manno-octulosonic-acid transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_966169_1 755178.Cyan10605_1006 5.4e-52 168.0 COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_966169_2 316275.VSAL_I2547 2.66e-08 54.3 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,1RMTD@1236|Gammaproteobacteria,1XUFU@135623|Vibrionales 135623|Vibrionales S Belongs to the UPF0246 family yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_432321_2 1240349.ANGC01000066_gene90 3.64e-70 222.0 COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4FUP9@85025|Nocardiaceae 201174|Actinobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_717129_2 76114.ebA977 3.3e-53 188.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_2788_1 614083.AWQR01000038_gene1400 3.07e-105 311.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,4AADT@80864|Comamonadaceae 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_466952_1 640081.Dsui_1871 1.03e-72 243.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KUKW@206389|Rhodocyclales 206389|Rhodocyclales V AcrB/AcrD/AcrF family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_895475_1 1408433.JHXV01000032_gene1103 2.64e-16 82.0 COG1131@1|root,COG1131@2|Bacteria,4NFJD@976|Bacteroidetes,1HXIN@117743|Flavobacteriia,2PBR4@246874|Cryomorphaceae 976|Bacteroidetes V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_288819_1 1000565.METUNv1_03463 1.13e-92 296.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,2KUZT@206389|Rhodocyclales 206389|Rhodocyclales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor - - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_823620_1 1000565.METUNv1_00325 1.42e-40 147.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2VI9M@28216|Betaproteobacteria,2KVMR@206389|Rhodocyclales 206389|Rhodocyclales N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_823620_2 1000565.METUNv1_00326 1.1e-194 550.0 COG5002@1|root,COG5002@2|Bacteria,1QVCN@1224|Proteobacteria,2WGQD@28216|Betaproteobacteria,2KZW6@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain fleS - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_8 k59_1074997_1 1000565.METUNv1_02723 1.28e-170 483.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,2KUSN@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1074997_2 748247.AZKH_3558 1.54e-14 73.2 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,2KUSW@206389|Rhodocyclales 206389|Rhodocyclales E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_966179_2 1100721.ALKO01000003_gene2251 5.52e-67 207.0 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,4A9XY@80864|Comamonadaceae 28216|Betaproteobacteria S UPF0114 protein - - - - - - - - - - - - UPF0114 k59_466962_1 305700.B447_04903 6.45e-14 75.9 COG0454@1|root,COG0503@1|root,COG0456@2|Bacteria,COG0503@2|Bacteria,1PF0X@1224|Proteobacteria,2WB5A@28216|Betaproteobacteria,2KZ8Q@206389|Rhodocyclales 206389|Rhodocyclales F acetyltransferase - - - - - - - - - - - - - k59_432338_1 323098.Nwi_1251 4.06e-79 243.0 28IPJ@1|root,2Z8PI@2|Bacteria,1N3K3@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_503856_1 1000565.METUNv1_01360 7.67e-157 448.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VM8B@28216|Betaproteobacteria,2KW9Z@206389|Rhodocyclales 206389|Rhodocyclales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_503856_2 1000565.METUNv1_01358 4.74e-152 432.0 COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,2VNJJ@28216|Betaproteobacteria,2KW2T@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,SoxZ k59_288836_1 1000565.METUNv1_00164 2.51e-91 268.0 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,2KWI7@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ - - - - - - - - - - - NUDIX k59_288836_2 76114.ebA988 5.17e-25 101.0 2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,2VSMP@28216|Betaproteobacteria,2KWQ8@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_395940_1 365046.Rta_08550 9.71e-61 197.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,4AADV@80864|Comamonadaceae 28216|Betaproteobacteria S peptidase dimerisation domain protein - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_395940_2 1276756.AUEX01000012_gene3582 1.29e-33 125.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VIJP@28216|Betaproteobacteria,4AADC@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_360246_2 1562701.BBOF01000044_gene1258 1.45e-84 262.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2VNV4@28216|Betaproteobacteria,1K7AD@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM RecT protein recT - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_788606_2 1121921.KB898708_gene1524 5.69e-102 298.0 28NG2@1|root,2ZBI9@2|Bacteria,1R98N@1224|Proteobacteria,1RYRF@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_216621_1 1000565.METUNv1_00187 4.42e-145 413.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,2KV4C@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_503857_1 1000565.METUNv1_02674 1.55e-46 155.0 2DQ3W@1|root,334M9@2|Bacteria,1NF29@1224|Proteobacteria,2VXAP@28216|Betaproteobacteria,2KZ8V@206389|Rhodocyclales 206389|Rhodocyclales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_503857_2 1000565.METUNv1_01064 1.31e-37 129.0 COG1917@1|root,COG1917@2|Bacteria,1NJEK@1224|Proteobacteria,2VXYU@28216|Betaproteobacteria 28216|Betaproteobacteria S ChrR Cupin-like domain - - - - - - - - - - - - Cupin_7 k59_503857_3 1000565.METUNv1_01054 5.36e-118 364.0 COG1289@1|root,COG1289@2|Bacteria,1MWR1@1224|Proteobacteria,2VJEF@28216|Betaproteobacteria,2KZHZ@206389|Rhodocyclales 206389|Rhodocyclales S FUSC-like inner membrane protein yccS - - - - - - - - - - - - FUSC-like,FUSC_2 k59_1109029_1 1000565.METUNv1_01445 3.69e-223 627.0 COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,2VK99@28216|Betaproteobacteria,2KVH8@206389|Rhodocyclales 206389|Rhodocyclales C Amidohydrolase family - - 1.2.7.12 ko:K00200 ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 k59_895508_1 1000565.METUNv1_04003 6.2e-127 374.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales 206389|Rhodocyclales C Glycolate oxidase subunit GlcD glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_823643_1 1502852.FG94_03626 1.95e-34 136.0 COG2199@1|root,COG2199@2|Bacteria,1RKMU@1224|Proteobacteria,2WBGU@28216|Betaproteobacteria,475SJ@75682|Oxalobacteraceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_823643_2 1198452.Jab_2c26070 3.38e-10 59.7 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,476JN@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC transporter transmembrane region mdlB - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1038343_1 930169.B5T_01454 1.32e-92 281.0 COG3239@1|root,COG3239@2|Bacteria,1QKDT@1224|Proteobacteria,1RQCX@1236|Gammaproteobacteria,1XNQW@135619|Oceanospirillales 135619|Oceanospirillales I fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_859081_1 1173264.KI913949_gene3377 2.36e-35 132.0 COG0676@1|root,COG0676@2|Bacteria,1G41U@1117|Cyanobacteria,1HA9U@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Aldose 1-epimerase - - 5.1.3.15 ko:K01792 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 - R02739 RC00563 ko00000,ko00001,ko01000 - - - Aldose_epim k59_680629_1 926549.KI421517_gene180 4.33e-114 335.0 COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,47JAQ@768503|Cytophagia 976|Bacteroidetes C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1002013_1 1005048.CFU_2125 1.76e-36 128.0 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2VT72@28216|Betaproteobacteria,474IJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_1002013_2 420662.Mpe_A2718 2.67e-69 212.0 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,1KMI5@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_1002013_3 420662.Mpe_A2719 5.35e-51 164.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2VU9V@28216|Betaproteobacteria,1KMGS@119065|unclassified Burkholderiales 28216|Betaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor bigR - - - - - - - - - - - HTH_5 k59_1002013_4 1157708.KB907462_gene907 1.47e-124 360.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,4ABHP@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein baeB - - - - - - - - - - - Lactamase_B k59_288864_1 59689.scaffold_501829.1 1.4e-20 90.9 COG4992@1|root,KOG1401@2759|Eukaryota,37NS6@33090|Viridiplantae,3G7N0@35493|Streptophyta,3HWTZ@3699|Brassicales 35493|Streptophyta E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family GSA2 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048046 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_288864_2 1187851.A33M_4287 7.92e-32 122.0 COG0204@1|root,COG0204@2|Bacteria,1MYXG@1224|Proteobacteria 1224|Proteobacteria I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_788623_1 395493.BegalDRAFT_3147 8.21e-30 122.0 COG2199@1|root,COG2199@2|Bacteria 2|Bacteria T diguanylate cyclase activity ytrP - 2.7.7.65 ko:K13069 - - R08057 - ko00000,ko01000 - - - GAF_2,GAF_3,GGDEF,HAMP k59_788623_2 1000565.METUNv1_04029 8.58e-53 170.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,2KW1R@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_1075046_1 1000565.METUNv1_02667 2.49e-144 417.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,2KV9G@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_467002_1 1100721.ALKO01000017_gene1710 1.75e-166 475.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,4AAVH@80864|Comamonadaceae 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_646703_1 1100720.ALKN01000024_gene1450 2.03e-09 57.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,4AA6B@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_646703_2 1123255.JHYS01000005_gene602 4.65e-19 80.1 2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2VXNC@28216|Betaproteobacteria,4AFVQ@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2970) - - - - - - - - - - - - DUF2970 k59_646703_3 232721.Ajs_3534 1.42e-43 147.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,4AADH@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM Cytochrome c oxidase assembly protein CtaG Cox11 ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_537884_1 700598.Niako_6041 3.26e-82 271.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1IWKA@117747|Sphingobacteriia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - FG-GAP,UnbV_ASPIC,VCBS k59_573509_1 1000565.METUNv1_00115 2.31e-129 403.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales 206389|Rhodocyclales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_966217_1 1000565.METUNv1_02523 5.13e-108 319.0 COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,2KW5M@206389|Rhodocyclales 206389|Rhodocyclales P Transcriptional regulator of molybdate metabolism, LysR family protein - - - - - - - - - - - - HTH_1,PBP_like k59_325387_1 1217703.F904_01650 1.4e-14 72.0 COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,1RQQ9@1236|Gammaproteobacteria,3NJSI@468|Moraxellaceae 1236|Gammaproteobacteria IQ KR domain hsdl2 - - ko:K13775 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short,adh_short_C2 k59_325387_2 1122951.ATUE01000007_gene738 6.33e-16 77.8 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,1RQD3@1236|Gammaproteobacteria,3NKGQ@468|Moraxellaceae 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182,ko:K13776 ko00281,map00281 - R08088 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1038379_1 700598.Niako_2524 4.61e-32 114.0 COG0346@1|root,COG0346@2|Bacteria,4NQCJ@976|Bacteroidetes,1IXZD@117747|Sphingobacteriia 976|Bacteroidetes E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1038379_2 1121957.ATVL01000012_gene841 9.12e-37 133.0 COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes,47NJ6@768503|Cytophagia 976|Bacteroidetes G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_182515_1 614083.AWQR01000009_gene519 9.02e-27 101.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,4AB1M@80864|Comamonadaceae 28216|Betaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_182515_2 535289.Dtpsy_0391 2.44e-31 110.0 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,2VVPT@28216|Betaproteobacteria,4AFGA@80864|Comamonadaceae 28216|Betaproteobacteria J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_288906_2 1123261.AXDW01000001_gene1488 1.08e-10 62.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1X30F@135614|Xanthomonadales 135614|Xanthomonadales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_1075090_1 1265502.KB905946_gene1114 3.37e-158 451.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,2VISF@28216|Betaproteobacteria,4ACI9@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM peptidase U32 - - - - - - - - - - - - Peptidase_U32 k59_1075090_2 987059.RBXJA2T_10571 4.71e-35 125.0 COG3154@1|root,COG3154@2|Bacteria,1RB7T@1224|Proteobacteria,2VTWW@28216|Betaproteobacteria,1KMC2@119065|unclassified Burkholderiales 28216|Betaproteobacteria I SCP-2 sterol transfer family - - - - - - - - - - - - SCP2 k59_1002047_2 1307437.J139_19106 4.04e-36 142.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T2C2@1236|Gammaproteobacteria,2Q03Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_253170_2 1000565.METUNv1_02544 4.93e-76 239.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,2KUND@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_646740_1 999547.KI421500_gene3555 2.62e-40 140.0 COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,2829H@191028|Leisingera 28211|Alphaproteobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_646740_2 172088.AUGA01000002_gene6174 1.76e-21 97.1 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Pkinase k59_752171_1 1000565.METUNv1_03637 1.43e-28 110.0 2DZ3T@1|root,32V6K@2|Bacteria,1N1CD@1224|Proteobacteria,2W3TW@28216|Betaproteobacteria,2KZ3D@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_752171_2 1000565.METUNv1_03638 1.31e-11 63.5 2E4IS@1|root,32ZDU@2|Bacteria,1N7N3@1224|Proteobacteria,2VVSI@28216|Betaproteobacteria,2KXJY@206389|Rhodocyclales 206389|Rhodocyclales S psiF repeat - - - - - - - - - - - - PsiF_repeat k59_752171_3 1000565.METUNv1_03639 2.13e-07 51.2 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,2KVU0@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_573536_2 102125.Xen7305DRAFT_00007190 1.67e-24 102.0 COG0022@1|root,COG0332@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG1071@2|Bacteria,1G246@1117|Cyanobacteria,3VI48@52604|Pleurocapsales 2|Bacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase fabH - 1.2.4.4,2.3.1.180,2.3.1.230 ko:K00648,ko:K11381,ko:K18002 ko00061,ko00280,ko00405,ko00640,ko01100,ko01110,ko01130,ko01212,ko02024,ko02025,map00061,map00280,map00405,map00640,map01100,map01110,map01130,map01212,map02024,map02025 M00036,M00082,M00083 R07599,R07600,R07601,R07602,R07603,R07604,R10589,R10590,R10707,R10996,R10997,R11589,R11590 RC00004,RC00027,RC00627,RC02729,RC02743,RC02883,RC02888,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000,ko01004 - - iIT341.HP0202 ACP_syn_III,ACP_syn_III_C,Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C k59_717214_1 1121374.KB891576_gene447 6.45e-32 115.0 2C9B9@1|root,32RP0@2|Bacteria,1MZKM@1224|Proteobacteria,1S8UZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S type III effector hopJ - - - - - - - - - - - HopJ k59_183454_1 335543.Sfum_1862 4.47e-34 136.0 COG4191@1|root,COG4251@1|root,COG5002@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions 1224|Proteobacteria T histidine kinase A domain protein - - - - - - - - - - - - DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_216999_1 1000565.METUNv1_00815 6.01e-77 239.0 COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,2VNVN@28216|Betaproteobacteria,2KWD0@206389|Rhodocyclales 206389|Rhodocyclales D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C,MinC_N k59_183467_1 1000565.METUNv1_02399 3.78e-114 334.0 COG5581@1|root,COG5581@2|Bacteria,1RJ1B@1224|Proteobacteria,2VTGM@28216|Betaproteobacteria,2KWP1@206389|Rhodocyclales 206389|Rhodocyclales M Flagellar protein YcgR - - - - - - - - - - - - PilZ,YcgR_2 k59_573993_1 1000565.METUNv1_01014 0.0 1106.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VIQ6@28216|Betaproteobacteria,2KUJM@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory protein, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_289696_1 1121101.HMPREF1532_02627 1.8e-25 100.0 COG0588@1|root,COG0588@2|Bacteria,4NFP5@976|Bacteroidetes,2FP93@200643|Bacteroidia,4AMX8@815|Bacteroidaceae 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_289696_2 640081.Dsui_1272 1.95e-27 102.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2VU9V@28216|Betaproteobacteria,2KWQT@206389|Rhodocyclales 206389|Rhodocyclales K transcriptional - - - - - - - - - - - - HTH_5 k59_1076108_1 1000565.METUNv1_02649 1.63e-91 277.0 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,2VH35@28216|Betaproteobacteria,2KW3R@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar rod assembly protein muramidase FlgJ flgJ - - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_896376_1 865937.Gilli_2940 8.62e-37 132.0 COG0604@1|root,COG0604@2|Bacteria,4NHHT@976|Bacteroidetes,1HYRT@117743|Flavobacteriia 976|Bacteroidetes C COG0604 NADPH quinone reductase and related Zn-dependent - - - - - - - - - - - - ADH_N,ADH_N_2,ADH_zinc_N_2 k59_896376_2 867902.Ornrh_1338 3.44e-30 112.0 COG1437@1|root,COG1437@2|Bacteria,4NQQK@976|Bacteroidetes,1I59E@117743|Flavobacteriia 976|Bacteroidetes F CYTH - - - - - - - - - - - - CYTH k59_467752_1 1000565.METUNv1_03485 3.66e-05 44.7 COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,2KV9Q@206389|Rhodocyclales 206389|Rhodocyclales O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - ko:K03188 - - - - ko00000 - - - UreF k59_467752_2 1000565.METUNv1_03486 3.82e-82 246.0 COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2VMRF@28216|Betaproteobacteria,2KWN7@206389|Rhodocyclales 206389|Rhodocyclales O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly ureE - - ko:K03187 - - - - ko00000 - - - UreE_C,UreE_N k59_574001_1 1000565.METUNv1_03580 4.03e-172 488.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2W9R7@28216|Betaproteobacteria,2KZDB@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_446822_1 640511.BC1002_4176 1.45e-120 369.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,1K1UZ@119060|Burkholderiaceae 28216|Betaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_338920_1 1122236.KB905141_gene1808 2.7e-39 143.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,2VMH5@28216|Betaproteobacteria,2KMBF@206350|Nitrosomonadales 206350|Nitrosomonadales E Aminopeptidase I zinc metalloprotease (M18) - - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_338920_2 1120936.KB907224_gene2525 4.25e-05 46.2 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4EH3M@85012|Streptosporangiales 201174|Actinobacteria T Transcriptional regulatory protein, C terminal mprA - - ko:K07669,ko:K07672 ko02020,map02020 M00460,M00463 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_724870_1 1000565.METUNv1_00821 1.8e-73 240.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_517718_1 1278073.MYSTI_08081 4.65e-15 75.9 COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,43BX8@68525|delta/epsilon subdivisions,2X781@28221|Deltaproteobacteria,2YZK7@29|Myxococcales 28221|Deltaproteobacteria T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,Response_reg k59_1011403_1 697282.Mettu_0660 3.74e-147 460.0 COG0784@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XH1G@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_262043_1 1250232.JQNJ01000001_gene3912 5.24e-09 60.1 COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,1HXTC@117743|Flavobacteriia 976|Bacteroidetes E gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_82818_1 614083.AWQR01000001_gene3099 2.05e-121 362.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,4AB4R@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_47531_1 1209072.ALBT01000052_gene569 1.03e-49 179.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NADH-quinone oxidoreductase nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iECs_1301.ECs3167,iG2583_1286.G2583_2820,iZ_1308.Z3542 Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_545657_1 1000565.METUNv1_02688 1.86e-161 460.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales 206389|Rhodocyclales M (Lipo)protein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_904537_1 1177179.A11A3_12620 2.15e-180 521.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria 1236|Gammaproteobacteria V type I restriction-modification system - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_517764_1 243159.AFE_0687 5.67e-81 255.0 COG0846@1|root,COG0846@2|Bacteria,1MW6J@1224|Proteobacteria,1SC02@1236|Gammaproteobacteria 1236|Gammaproteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_580288_1 748247.AZKH_2100 1.26e-43 154.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,2KUJP@206389|Rhodocyclales 206389|Rhodocyclales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_223594_1 760117.JN27_04285 2.05e-58 191.0 COG2267@1|root,COG2267@2|Bacteria,1QVFU@1224|Proteobacteria 1224|Proteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1012480_1 1000565.METUNv1_00625 9.49e-10 57.0 COG3073@1|root,COG3073@2|Bacteria,1QANZ@1224|Proteobacteria,2VVPR@28216|Betaproteobacteria,2KXA7@206389|Rhodocyclales 206389|Rhodocyclales T Anti sigma-E protein RseA rseA - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_1012480_2 1000565.METUNv1_00624 3.56e-119 342.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,2KUG9@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_663212_1 887062.HGR_05551 9.15e-71 226.0 COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,2VHDP@28216|Betaproteobacteria,4A9ST@80864|Comamonadaceae 28216|Betaproteobacteria O MreB/Mbl protein yegD - - ko:K04046 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_938531_1 1000565.METUNv1_00301 1.77e-53 175.0 2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,2W4MN@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_519727_1 1122951.ATUE01000006_gene1310 5.77e-106 327.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,3NK7W@468|Moraxellaceae 1236|Gammaproteobacteria O ATP-dependent Clp protease ATP-binding subunit clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_477010_1 1000565.METUNv1_01944 2.81e-31 113.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,2KWHZ@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_477010_2 1000565.METUNv1_01945 8.68e-210 584.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KURZ@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_726164_1 1000565.METUNv1_02706 6.38e-133 408.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVC1@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_581246_1 338969.Rfer_2686 3.87e-99 300.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,4AAHX@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_119069_1 232721.Ajs_4005 2.15e-86 273.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,4A9UJ@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_223615_1 795666.MW7_1014 1.56e-95 281.0 28HUJ@1|root,2Z819@2|Bacteria,1MW8B@1224|Proteobacteria,2VM17@28216|Betaproteobacteria,1KDC1@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_223615_2 795666.MW7_1013 1.54e-63 208.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VHAI@28216|Betaproteobacteria,1KFM6@119060|Burkholderiaceae 28216|Betaproteobacteria L helicase superfamily c-terminal domain - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_1047480_1 1380346.JNIH01000014_gene777 1.81e-44 160.0 COG3573@1|root,COG3573@2|Bacteria,2GIYM@201174|Actinobacteria 201174|Actinobacteria S Dehydrogenase - - - ko:K07077 - - - - ko00000 - - - FAD_binding_2 k59_341029_1 1234595.C725_2528 4.82e-37 137.0 COG5397@1|root,COG5397@2|Bacteria,1R4MR@1224|Proteobacteria,2U2XQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Nucleotidyltransferase - - - - - - - - - - - - NTP_transf_8 k59_868923_1 232721.Ajs_0963 7.05e-78 253.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,4AC2I@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM NADH-quinone oxidoreductase, chain G nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_615511_1 929703.KE386491_gene1061 1.11e-74 231.0 COG0190@1|root,COG0190@2|Bacteria,4NEJP@976|Bacteroidetes,47K0S@768503|Cytophagia 976|Bacteroidetes F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_615511_2 237368.SCABRO_00561 1.46e-06 49.7 COG0550@1|root,COG0550@2|Bacteria,2IY53@203682|Planctomycetes 203682|Planctomycetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1047504_1 1198452.Jab_1c20820 1.4e-130 395.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria,478GF@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_198494_1 1122951.ATUE01000005_gene2223 7.78e-111 332.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,3NJKS@468|Moraxellaceae 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_341057_1 714943.Mucpa_5187 5.74e-74 251.0 COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,1INMI@117747|Sphingobacteriia 976|Bacteroidetes S alpha-2-macroglobulin domain protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl k59_546978_1 398767.Glov_0290 7.24e-71 224.0 COG3183@1|root,COG3183@2|Bacteria,1MZRA@1224|Proteobacteria,42W8N@68525|delta/epsilon subdivisions,2WRC6@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM HNH endonuclease - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH k59_341074_1 1005048.CFU_3476 4.7e-53 169.0 COG3794@1|root,COG3794@2|Bacteria,1RH5A@1224|Proteobacteria,2VSEN@28216|Betaproteobacteria,474NF@75682|Oxalobacteraceae 28216|Betaproteobacteria C Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_834353_1 452637.Oter_1627 2.13e-45 159.0 COG0697@1|root,COG0697@2|Bacteria,46SR7@74201|Verrucomicrobia 74201|Verrucomicrobia EG EamA-like transporter family - - - - - - - - - - - - EamA k59_799253_1 720554.Clocl_4068 4.46e-20 86.3 COG4843@1|root,COG4843@2|Bacteria,1V14J@1239|Firmicutes,24J7S@186801|Clostridia,3WIWY@541000|Ruminococcaceae 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 k59_868968_1 232721.Ajs_3960 3.67e-116 339.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,4AAB9@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1047550_1 1000565.METUNv1_02092 7.54e-64 202.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,2KVIW@206389|Rhodocyclales 206389|Rhodocyclales C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1047550_2 1217718.ALOU01000038_gene3384 3.07e-07 49.7 2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2VXNC@28216|Betaproteobacteria,1KABT@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2970) - - - - - - - - - - - - DUF2970 k59_868980_1 1276756.AUEX01000020_gene3367 4.55e-47 171.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - 3.6.4.12 ko:K06919,ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,D5_N,DUF3987,DUF927,Toprim_2,Toprim_3 k59_663352_1 985867.AEWF01000003_gene664 1.39e-53 184.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2TUN4@28211|Alphaproteobacteria,47G0Q@766|Rickettsiales 766|Rickettsiales C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_263466_1 1122951.ATUE01000005_gene1543 1.64e-18 80.9 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,3NNWM@468|Moraxellaceae 1236|Gammaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_263466_2 520709.F985_03724 2.17e-44 149.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,3NIT4@468|Moraxellaceae 1236|Gammaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030163,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0052689,GO:0071704,GO:0140098,GO:0140101,GO:1901564,GO:1901565,GO:1901575 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_119161_2 1122201.AUAZ01000023_gene3029 2.09e-26 110.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,467IV@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_371362_2 1003200.AXXA_27970 6.85e-07 50.8 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2VSX1@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_448998_1 863365.XHC_4295 3.39e-37 134.0 28M2G@1|root,2ZAGX@2|Bacteria,1QDCH@1224|Proteobacteria,1RYYF@1236|Gammaproteobacteria,1XA37@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3800) - - - - - - - - - - - - DUF3800 k59_448998_2 1286631.X805_28090 1.59e-26 107.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,2VHIR@28216|Betaproteobacteria,1KMXP@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_198571_1 204773.HEAR2443 1.8e-92 276.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,473K0@75682|Oxalobacteraceae 28216|Betaproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_263482_2 690850.Desaf_3555 8.86e-28 111.0 COG4675@1|root,COG5301@1|root,COG4675@2|Bacteria,COG5301@2|Bacteria,1N0FZ@1224|Proteobacteria,42TXS@68525|delta/epsilon subdivisions 1224|Proteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_1012593_1 1121897.AUGO01000010_gene2820 1.06e-34 124.0 COG4675@1|root,COG4675@2|Bacteria,4NQJR@976|Bacteroidetes,1I31T@117743|Flavobacteriia,2NX1Q@237|Flavobacterium 976|Bacteroidetes S PFAM phage Tail Collar domain - - - - - - - - - - - - Collar k59_405098_1 159450.NH14_15645 1.14e-27 109.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,1K088@119060|Burkholderiaceae 28216|Betaproteobacteria E ABC transporter artM_2 - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_405098_2 1353529.M899_0908 5.57e-14 69.7 COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42N9B@68525|delta/epsilon subdivisions,2MU44@213481|Bdellovibrionales,2X24S@28221|Deltaproteobacteria 213481|Bdellovibrionales E Binding-protein-dependent transport system inner membrane component - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_477117_2 926549.KI421517_gene1616 3.26e-19 86.7 COG4313@1|root,COG4313@2|Bacteria,4NIIB@976|Bacteroidetes,47SDW@768503|Cytophagia 976|Bacteroidetes C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_263510_1 748247.AZKH_3168 1.65e-178 515.0 COG0145@1|root,COG0145@2|Bacteria,1R3RA@1224|Proteobacteria,2VZPU@28216|Betaproteobacteria,2KYJI@206389|Rhodocyclales 206389|Rhodocyclales J Hydantoinase/oxoprolinase N-terminal region - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_198618_1 596154.Alide2_2408 2.05e-63 203.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,4AA48@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_198618_2 1219031.BBJR01000053_gene2196 1.3e-47 162.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2VIKG@28216|Betaproteobacteria,4AC8S@80864|Comamonadaceae 28216|Betaproteobacteria S Fad dependent oxidoreductase lhgO - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO k59_905607_1 194867.ALBQ01000003_gene1185 2.52e-96 309.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2KCZ7@204457|Sphingomonadales 204457|Sphingomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1047669_1 1000565.METUNv1_03226 1.64e-81 257.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,2KV5T@206389|Rhodocyclales 206389|Rhodocyclales C Nickel-dependent hydrogenase - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1047669_2 1000565.METUNv1_03225 8.84e-53 171.0 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2VTYR@28216|Betaproteobacteria,2KXCK@206389|Rhodocyclales 206389|Rhodocyclales O HupE UreJ protein - - - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_48947_2 1439940.BAY1663_00266 7.29e-28 112.0 COG0466@1|root,COG1219@1|root,COG0466@2|Bacteria,COG1219@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_519973_1 1000565.METUNv1_01484 4.71e-124 377.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_1117342_1 1000565.METUNv1_03372 4.05e-27 105.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,2KU85@206389|Rhodocyclales 206389|Rhodocyclales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1117342_2 1000565.METUNv1_03371 1.59e-142 415.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,2KV0S@206389|Rhodocyclales 206389|Rhodocyclales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_223737_1 1100720.ALKN01000037_gene1899 1.2e-84 266.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VNJ6@28216|Betaproteobacteria,4AJ70@80864|Comamonadaceae 28216|Betaproteobacteria E MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_905630_1 685727.REQ_38990 4.48e-18 84.3 COG4977@1|root,COG4977@2|Bacteria,2I8TR@201174|Actinobacteria,4G8U0@85025|Nocardiaceae 201174|Actinobacteria K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_615602_1 395495.Lcho_3851 1.03e-10 68.6 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VM1W@28216|Betaproteobacteria,1KK7W@119065|unclassified Burkholderiales 28216|Betaproteobacteria S 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1,Lactonase k59_689324_1 614083.AWQR01000005_gene1060 9.55e-109 325.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,4ABTY@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_155529_1 1100720.ALKN01000045_gene113 4.86e-73 236.0 COG1073@1|root,COG1073@2|Bacteria,1QTY2@1224|Proteobacteria,2VK86@28216|Betaproteobacteria,4AB75@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Tannase and feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_405133_1 1000565.METUNv1_02302 9.36e-73 233.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,2KUDC@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_689331_1 700598.Niako_5584 1.89e-50 174.0 COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,1IPWT@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1047721_1 338963.Pcar_0299 3.85e-45 167.0 COG2202@1|root,COG2203@1|root,COG3920@1|root,COG4936@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,COG4936@2|Bacteria,COG5002@2|Bacteria,1MVPJ@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_4,PAS_9,PocR,dCache_2 k59_520015_1 1000565.METUNv1_03671 2.99e-78 268.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_520015_2 1000565.METUNv1_03670 5.42e-41 142.0 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,2VW0N@28216|Betaproteobacteria,2KXJA@206389|Rhodocyclales 206389|Rhodocyclales S FecR protein - - - - - - - - - - - - FecR k59_449143_1 202952.BBLI01000090_gene3752 2.54e-35 127.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,3NN87@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the HSP15 family hslR GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_449143_2 1410619.SRDD_23500 9.78e-19 84.7 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,401AY@613|Serratia 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_300217_1 614083.AWQR01000029_gene2177 3.72e-117 346.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,4ABG0@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_263584_1 1265502.KB905950_gene926 2.83e-151 461.0 COG1200@1|root,COG1200@2|Bacteria,1QWSU@1224|Proteobacteria,2VPIB@28216|Betaproteobacteria,4ACED@80864|Comamonadaceae 28216|Betaproteobacteria KL Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C k59_992712_1 1000565.METUNv1_03671 3.11e-25 112.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_922041_1 640081.Dsui_2313 1.89e-112 337.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,2KVHT@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_744730_1 640081.Dsui_1918 8.52e-113 343.0 COG1765@1|root,COG1944@1|root,COG1765@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,2VHZY@28216|Betaproteobacteria,2KV2Z@206389|Rhodocyclales 206389|Rhodocyclales O redox protein, regulator of disulfide bond formation - - - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO k59_816677_1 1237149.C900_00531 1.79e-06 50.4 COG1999@1|root,COG1999@2|Bacteria,4NFH2@976|Bacteroidetes,47NK1@768503|Cytophagia 976|Bacteroidetes S protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1032569_1 1121918.ARWE01000001_gene3203 9.88e-07 52.0 COG2199@1|root,COG3290@1|root,COG2199@2|Bacteria,COG3290@2|Bacteria,1RGCV@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,CHASE8,EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_499356_1 861299.J421_1701 2.99e-57 193.0 COG1696@1|root,COG1696@2|Bacteria,1ZV39@142182|Gemmatimonadetes 142182|Gemmatimonadetes M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_174812_1 614083.AWQR01000039_gene1495 5.44e-79 252.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,4AG8M@80864|Comamonadaceae 28216|Betaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_744783_1 925409.KI911562_gene1855 1.25e-143 416.0 COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,1IQDI@117747|Sphingobacteriia 976|Bacteroidetes S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_744784_1 1198452.Jab_2c20670 6.55e-61 193.0 COG3637@1|root,COG3637@2|Bacteria,1NIE3@1224|Proteobacteria,2VXMU@28216|Betaproteobacteria,478B6@75682|Oxalobacteraceae 28216|Betaproteobacteria M OmpA-like transmembrane domain - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA_membrane k59_890707_1 1000565.METUNv1_02373 1.47e-162 457.0 COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,2VMQ4@28216|Betaproteobacteria,2KV7Q@206389|Rhodocyclales 206389|Rhodocyclales G COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_776346_1 95619.PM1_0200775 6.32e-98 310.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_499395_1 232721.Ajs_3018 7.56e-114 341.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,4ABQ6@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family wlbC - 2.6.1.98 ko:K13017 ko00520,map00520 - R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_499411_1 1198452.Jab_2c27070 8.27e-23 100.0 COG0859@1|root,COG3307@1|root,COG0859@2|Bacteria,COG3307@2|Bacteria,1N5A1@1224|Proteobacteria,2W0VF@28216|Betaproteobacteria,473HU@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_855276_1 296591.Bpro_3029 4.5e-119 345.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,4AAVB@80864|Comamonadaceae 28216|Betaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_1032646_1 1287116.X734_26280 1.14e-33 119.0 COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,2U9C1@28211|Alphaproteobacteria,43MCP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase vapC_2 - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_1032646_2 1287116.X734_26285 9.76e-29 105.0 COG4456@1|root,COG4456@2|Bacteria,1NA9N@1224|Proteobacteria,2UI0K@28211|Alphaproteobacteria,43QNF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S SpoVT / AbrB like domain ntrP - - ko:K18829 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_499424_1 398578.Daci_3963 3.34e-82 257.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,4A9ND@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Three-deoxy-D-manno-octulosonic-acid transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_992804_1 232721.Ajs_3764 6.14e-121 360.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHAT@28216|Betaproteobacteria,4ABV3@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_992810_1 469660.A8HNX4_9CAUD 9.76e-23 100.0 4QBFN@10239|Viruses,4QXWN@35237|dsDNA viruses no RNA stage,4QPTW@28883|Caudovirales,4QNPZ@10744|Podoviridae 10744|Podoviridae S Phage stabilisation protein - - - - - - - - - - - - - k59_992810_2 60520.HR47_04400 9.66e-05 47.0 COG5434@1|root,COG5434@2|Bacteria,1VNJF@1239|Firmicutes,4HRXJ@91061|Bacilli 91061|Bacilli M Pectate lyase superfamily protein - - - - - - - - - - - - F5_F8_type_C,Pectate_lyase_3 k59_568019_1 862908.BMS_0727 5.22e-21 92.4 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - - - - - - - - - - TPR_16,TPR_6 k59_137981_1 614083.AWQR01000009_gene733 5.78e-62 208.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4ABWU@80864|Comamonadaceae 28216|Betaproteobacteria T Adenylate cyclase cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_137981_2 296591.Bpro_4676 5.63e-33 120.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,4AA3Q@80864|Comamonadaceae 28216|Betaproteobacteria S cAMP phosphodiesterases class-II - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_103734_1 1286631.X805_11500 9.5e-70 219.0 COG0543@1|root,COG0543@2|Bacteria,1QTSK@1224|Proteobacteria,2VH0M@28216|Betaproteobacteria,1KJGD@119065|unclassified Burkholderiales 28216|Betaproteobacteria CH Oxidoreductase FAD-binding domain fpr - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_597261_2 1454004.AW11_01725 1.06e-48 157.0 COG2944@1|root,COG2944@2|Bacteria,1N48U@1224|Proteobacteria,2VUHQ@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 k59_597261_3 640081.Dsui_2136 2.96e-35 129.0 COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,2VK7Z@28216|Betaproteobacteria,2KVBZ@206389|Rhodocyclales 206389|Rhodocyclales C Radical SAM - - - - - - - - - - - - - k59_239887_1 365044.Pnap_3568 2.38e-25 104.0 COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,2VJ4B@28216|Betaproteobacteria,4AJZ2@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Phosphate acetyl butaryl transferase - - 2.3.1.19,2.3.1.8 ko:K00625,ko:K00634 ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921,R01174 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas,PTA_PTB k59_239887_2 365044.Pnap_3566 8.81e-33 126.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,4ABM7@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase phbC2 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_138010_1 243365.CV_1168 4.79e-36 135.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - MFS_1,MFS_3 k59_890860_1 700598.Niako_2639 2.33e-80 243.0 COG2884@1|root,COG2884@2|Bacteria,4NEP2@976|Bacteroidetes,1IQ4U@117747|Sphingobacteriia 976|Bacteroidetes D ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_954167_1 71421.HI_1707 7.34e-15 76.6 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1T1G3@1236|Gammaproteobacteria,1Y8AI@135625|Pasteurellales 135625|Pasteurellales T Sensor protein qseC qseC - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_954167_2 1198232.CYCME_2313 2.62e-12 64.3 2CEN3@1|root,2ZX63@2|Bacteria,1P720@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 k59_239922_2 1353529.M899_0194 1.91e-15 75.5 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2MSPS@213481|Bdellovibrionales,2WJR3@28221|Deltaproteobacteria 213481|Bdellovibrionales L PFAM UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_776539_1 1121935.AQXX01000114_gene3236 3.65e-61 193.0 COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RRDJ@1236|Gammaproteobacteria,1XMZB@135619|Oceanospirillales 135619|Oceanospirillales S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_776539_2 236097.ADG881_2800 2.77e-41 142.0 COG2013@1|root,COG2013@2|Bacteria,1R4EW@1224|Proteobacteria,1RZU1@1236|Gammaproteobacteria,1XNT7@135619|Oceanospirillales 135619|Oceanospirillales S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_890900_1 925409.KI911562_gene2687 1.73e-98 315.0 COG1196@1|root,COG1196@2|Bacteria,4NHWQ@976|Bacteroidetes,1IPD0@117747|Sphingobacteriia 976|Bacteroidetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_499591_1 420662.Mpe_A2806 1.07e-169 487.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VKZS@28216|Betaproteobacteria,1KIZV@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nickel-dependent hydrogenase hoxC - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_499591_2 1000565.METUNv1_03205 2.34e-21 90.9 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VKE2@28216|Betaproteobacteria,2KVZC@206389|Rhodocyclales 206389|Rhodocyclales C NiFe/NiFeSe hydrogenase small subunit C-terminal hoxB - 1.12.7.2 ko:K00534 - - R00019 - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_499593_1 1000565.METUNv1_01163 7.85e-162 457.0 2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2WGPR@28216|Betaproteobacteria,2KW4Y@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_138072_1 159087.Daro_3443 1.55e-17 79.7 COG1278@1|root,COG3326@1|root,COG1278@2|Bacteria,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,2VQXP@28216|Betaproteobacteria,2KX2F@206389|Rhodocyclales 206389|Rhodocyclales K Protein of unknown function (DUF1294) - - - - - - - - - - - - CSD,DUF1294 k59_70454_1 930166.CD58_17485 1.29e-38 147.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,1RRTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase M50 - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3 k59_1139237_1 1504672.669785927 4.31e-55 173.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,4ADIE@80864|Comamonadaceae 28216|Betaproteobacteria U general secretion pathway protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_1139237_2 338969.Rfer_0535 3.9e-28 106.0 COG4970@1|root,COG4970@2|Bacteria,1RIET@1224|Proteobacteria,2VUD5@28216|Betaproteobacteria,4AEEX@80864|Comamonadaceae 28216|Betaproteobacteria U General secretion pathway protein H - - - ko:K02457 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspH,N_methyl k59_748937_1 1030157.AFMP01000051_gene316 7.91e-12 65.1 COG3832@1|root,COG3832@2|Bacteria,1N2PR@1224|Proteobacteria,2VGJB@28211|Alphaproteobacteria,2KE45@204457|Sphingomonadales 204457|Sphingomonadales J glyoxalase III activity - - - - - - - - - - - - Polyketide_cyc2 k59_748937_2 1500897.JQNA01000002_gene4286 3.38e-13 68.2 COG3938@1|root,COG3938@2|Bacteria,1NVF9@1224|Proteobacteria,2VHHY@28216|Betaproteobacteria,1K4R9@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the proline racemase family - GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661 5.1.1.8 ko:K12658 ko00330,map00330 - R03296 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase k59_711084_1 1242864.D187_008594 7.88e-61 197.0 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1RE8Z@1224|Proteobacteria,42VZV@68525|delta/epsilon subdivisions,2WRHV@28221|Deltaproteobacteria,2YWGA@29|Myxococcales 28221|Deltaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - Cupin_2,HTH_3 k59_70457_1 1157708.KB907450_gene5441 1.05e-27 128.0 COG5434@1|root,COG5434@2|Bacteria,1RCW1@1224|Proteobacteria,2W4G2@28216|Betaproteobacteria 28216|Betaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_70459_1 326427.Cagg_0674 1.93e-07 58.2 COG1215@1|root,COG1215@2|Bacteria,2G6RJ@200795|Chloroflexi,375GG@32061|Chloroflexia 32061|Chloroflexia M PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_34111_2 83406.HDN1F_13650 5.78e-44 159.0 COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,1RYNI@1236|Gammaproteobacteria,1J4Y0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent peptidases - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_957463_1 398767.Glov_0291 5.51e-82 259.0 COG0323@1|root,COG0323@2|Bacteria,1P2C7@1224|Proteobacteria,42XB9@68525|delta/epsilon subdivisions 1224|Proteobacteria L Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c_3 k59_780232_1 596154.Alide2_4815 5.62e-94 283.0 COG0270@1|root,COG0270@2|Bacteria,1MV9D@1224|Proteobacteria,2VS86@28216|Betaproteobacteria,4AFU7@80864|Comamonadaceae 28216|Betaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_243572_1 522306.CAP2UW1_1243 5.21e-24 106.0 COG0022@1|root,COG0332@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,1KPNJ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH_1 - 1.2.4.4,2.3.1.180 ko:K00648,ko:K11381 ko00061,ko00280,ko00640,ko01100,ko01110,ko01130,ko01212,map00061,map00280,map00640,map01100,map01110,map01130,map01212 M00036,M00082,M00083 R07599,R07600,R07601,R07602,R07603,R07604,R10707,R10996,R10997 RC00004,RC00027,RC00627,RC02729,RC02743,RC02883,RC02888,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_780279_1 509635.N824_00800 1.29e-75 246.0 COG3507@1|root,COG3507@2|Bacteria,4NEIZ@976|Bacteroidetes,1INVT@117747|Sphingobacteriia 976|Bacteroidetes G PFAM Glycoside hydrolase, family 43 - - - - - - - - - - - - Glyco_hydro_43 k59_711191_1 1244869.H261_04088 3.63e-19 91.7 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JPVE@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_34186_1 365044.Pnap_0738 5.93e-55 191.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,4A9XE@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_34186_2 614083.AWQR01000017_gene2289 4.52e-09 57.4 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,4AAYI@80864|Comamonadaceae 28216|Betaproteobacteria M Peptidase M23B - - 3.4.24.75 ko:K08259 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_600652_1 396588.Tgr7_2617 1.93e-09 62.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_711197_1 1521187.JPIM01000056_gene2607 5e-40 152.0 COG1164@1|root,COG1164@2|Bacteria,2G5UV@200795|Chloroflexi,376XT@32061|Chloroflexia 32061|Chloroflexia E PFAM peptidase M3A and M3B, thimet oligopeptidase F - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1139332_2 1234664.AMRO01000027_gene1315 4.79e-42 152.0 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,4H9P8@91061|Bacilli,1WFMM@129337|Geobacillus 91061|Bacilli S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043934,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_780311_1 29581.BW37_04678 1.32e-27 109.0 COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VQ5B@28216|Betaproteobacteria,476JX@75682|Oxalobacteraceae 28216|Betaproteobacteria E Spermidine synthase speE2 - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_780332_1 379731.PST_0293 6.77e-89 278.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1Z1CS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_600695_1 1411685.U062_02113 1.35e-38 146.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1J6YF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_996631_1 1307437.J139_07357 5.83e-10 56.6 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,1S91G@1236|Gammaproteobacteria,2Q2N4@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T Belongs to the BolA IbaG family bolA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_996631_2 990073.ATHU01000001_gene992 4.54e-20 85.9 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2YPJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_957558_2 369723.Strop_0524 1.45e-23 102.0 2D5AF@1|root,32TIM@2|Bacteria,2IFIY@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - PDDEXK_1 k59_34231_1 1123367.C666_02460 5.11e-32 118.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,2KUH5@206389|Rhodocyclales 206389|Rhodocyclales J Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_34231_2 522306.CAP2UW1_2876 1.4e-101 299.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,1KPWC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1139376_1 535289.Dtpsy_1813 2.19e-147 429.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,4A9T8@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM methylmalonate-semialdehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_996645_1 2045.KR76_22090 1.01e-42 147.0 COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DQGE@85009|Propionibacteriales 201174|Actinobacteria G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_996686_1 240016.ABIZ01000001_gene2828 6.34e-24 101.0 COG0422@1|root,COG0422@2|Bacteria,46S5R@74201|Verrucomicrobia,2ITWP@203494|Verrucomicrobiae 203494|Verrucomicrobiae H ThiC-associated domain - - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_243733_1 296591.Bpro_0800 1.38e-101 300.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,4AAEE@80864|Comamonadaceae 28216|Betaproteobacteria V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_925407_1 1121033.AUCF01000008_gene5673 2.8e-65 218.0 COG5316@1|root,COG5316@2|Bacteria,1NWFX@1224|Proteobacteria,2U10J@28211|Alphaproteobacteria,2JRGI@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_425208_1 1179778.PMM47T1_08801 8.14e-41 142.0 COG0491@1|root,COG0491@2|Bacteria,1R9Z7@1224|Proteobacteria 1224|Proteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_328771_1 1000565.METUNv1_02877 1.81e-112 334.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_328771_2 1000565.METUNv1_02876 3.8e-67 216.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,2KUT9@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_398682_1 1000565.METUNv1_03634 1.5e-97 290.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWIW@206389|Rhodocyclales 206389|Rhodocyclales T Forkhead associated domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_1040792_1 864051.BurJ1DRAFT_1004 4.83e-35 131.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VIRD@28216|Betaproteobacteria,1KJ3D@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family nifV - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_1040792_2 269482.Bcep1808_5986 1.03e-28 110.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,1K1SD@119060|Burkholderiaceae 28216|Betaproteobacteria E serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_111680_1 1004149.AFOE01000041_gene1189 6.45e-21 97.4 COG2885@1|root,COG2885@2|Bacteria,4NKCW@976|Bacteroidetes,1HXSH@117743|Flavobacteriia 976|Bacteroidetes M PFAM Outer membrane protein, OmpA MotB, C-terminal - - - - - - - - - - - - OmpA k59_328787_1 977880.RALTA_A0392 9.79e-93 285.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,1K5EX@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K14392 - - - - ko00000,ko02000 2.A.21.1 - - SSF k59_1078725_1 1000565.METUNv1_03868 2.22e-207 604.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,2KVBE@206389|Rhodocyclales 206389|Rhodocyclales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_469342_1 644968.DFW101_2940 4.81e-22 97.8 COG1467@1|root,COG3378@1|root,COG1467@2|Bacteria,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,42QNW@68525|delta/epsilon subdivisions,2WMSE@28221|Deltaproteobacteria,2M9CB@213115|Desulfovibrionales 28221|Deltaproteobacteria L primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N k59_898166_1 95619.PM1_0221785 3.54e-29 114.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cupin 4 family protein ycfD GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_1004544_1 1173020.Cha6605_1221 0.000208 45.8 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1GHFQ@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Response_reg k59_1110721_1 257313.BP3465 3.88e-06 47.8 COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria,3T844@506|Alcaligenaceae 28216|Betaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_1110721_2 983917.RGE_17280 1.72e-25 102.0 COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2VQE7@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM alpha beta hydrolase fold - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Hydrolase_4 k59_719003_1 614083.AWQR01000009_gene711 2.67e-47 155.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,4AE3J@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose aut - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_719003_2 232721.Ajs_4019 8.27e-46 166.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,4A9PB@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_4865_1 535289.Dtpsy_0130 1.55e-80 254.0 COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,2VMJX@28216|Betaproteobacteria,4AAD4@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_328805_1 1118153.MOY_13461 1.19e-22 102.0 COG0457@1|root,COG3071@1|root,COG0457@2|Bacteria,COG3071@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1XI7D@135619|Oceanospirillales 135619|Oceanospirillales H COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_6,TPR_8 k59_76503_1 338969.Rfer_4073 7.76e-63 209.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria 28216|Betaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - - k59_41379_1 1000565.METUNv1_03590 3.88e-67 212.0 COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,2KUNE@206389|Rhodocyclales 206389|Rhodocyclales G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_826227_2 862517.HMPREF9225_1867 1.15e-05 47.4 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,22H03@1570339|Peptoniphilaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like k59_753828_1 1276756.AUEX01000005_gene2662 6.62e-179 515.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_898178_1 1000565.METUNv1_02479 5.07e-163 461.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,2KUKK@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_898178_2 1000565.METUNv1_02478 3.08e-100 292.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,2KV5Y@206389|Rhodocyclales 206389|Rhodocyclales E Acetolactate synthase small ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_898178_3 292.DM42_2797 3.46e-27 110.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,1JZU0@119060|Burkholderiaceae 28216|Betaproteobacteria H acetolactate synthase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_186044_1 1123367.C666_14545 4.93e-59 190.0 COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VSMN@28216|Betaproteobacteria,2KWD7@206389|Rhodocyclales 206389|Rhodocyclales K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - ko:K02479 - - - - ko00000,ko02022 - - - GerE,Response_reg k59_362600_1 349124.Hhal_0970 4.36e-07 50.4 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales 135613|Chromatiales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_362600_2 1122951.ATUE01000005_gene1966 1.66e-36 136.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,3NIQY@468|Moraxellaceae 1236|Gammaproteobacteria KT HD domain spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_291576_1 1038862.KB893841_gene94 2.31e-36 141.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JR8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_1078772_1 1000565.METUNv1_00565 1.44e-97 286.0 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,2KWCY@206389|Rhodocyclales 206389|Rhodocyclales O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB - - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - HSCB_C k59_1078772_2 1000565.METUNv1_00566 4.82e-239 671.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,2KUV2@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_147131_1 1042375.AFPL01000023_gene1674 2.52e-81 269.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_9,Protoglobin k59_753834_1 1000565.METUNv1_02802 1.91e-54 179.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2WI38@28216|Betaproteobacteria 28216|Betaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - - - - - - - - - - - Iso_dh k59_753834_2 1000565.METUNv1_02801 5.01e-134 383.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,2KU7N@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1040834_2 497964.CfE428DRAFT_3842 1.61e-70 229.0 COG2303@1|root,COG2303@2|Bacteria,46V0V@74201|Verrucomicrobia 74201|Verrucomicrobia E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_1078795_1 1217652.F954_00134 2.93e-38 147.0 COG2206@1|root,COG3290@1|root,COG2206@2|Bacteria,COG3290@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria,3NMUM@468|Moraxellaceae 1236|Gammaproteobacteria T HD domain - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_3,PAS_4,PAS_9 k59_291589_1 1000565.METUNv1_00197 2.83e-110 339.0 COG4206@1|root,COG4206@2|Bacteria,1QUPS@1224|Proteobacteria,2WH5H@28216|Betaproteobacteria 28216|Betaproteobacteria P TIGRFAM TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_291589_2 666681.M301_0053 0.000116 47.4 2EKNW@1|root,33ECK@2|Bacteria,1NGE2@1224|Proteobacteria,2W51U@28216|Betaproteobacteria,2KNWC@206350|Nitrosomonadales 206350|Nitrosomonadales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_398749_1 1245471.PCA10_52590 7.69e-14 71.2 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1YE8T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_398749_2 1109445.AGSX01000117_gene3376 2.97e-17 79.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1Z0WT@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_41400_1 1123487.KB892867_gene885 1.31e-18 84.7 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria,2KV32@206389|Rhodocyclales 206389|Rhodocyclales S fad dependent oxidoreductase - - - ko:K07137 - - - - ko00000 - - - HI0933_like k59_41400_2 1000565.METUNv1_00160 7.74e-182 511.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,2KVC0@206389|Rhodocyclales 206389|Rhodocyclales S alpha/beta hydrolase fold - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_41400_3 1000565.METUNv1_00161 2.58e-55 176.0 COG3631@1|root,COG3631@2|Bacteria,1QXIX@1224|Proteobacteria,2WH4R@28216|Betaproteobacteria,2KZY7@206389|Rhodocyclales 206389|Rhodocyclales S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_507495_2 1000565.METUNv1_03140 1.34e-24 94.4 COG2944@1|root,COG2944@2|Bacteria,1NHAH@1224|Proteobacteria,2VXNT@28216|Betaproteobacteria,2KZCN@206389|Rhodocyclales 206389|Rhodocyclales K sequence-specific DNA binding - - - - - - - - - - - - - k59_147142_2 1500894.JQNN01000001_gene871 1.88e-22 94.4 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VICP@28216|Betaproteobacteria,472WM@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_575238_1 1000565.METUNv1_01987 1.03e-54 189.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KXW1@206389|Rhodocyclales 206389|Rhodocyclales K GAF domain - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_575238_2 1000565.METUNv1_01986 8.77e-47 154.0 COG2010@1|root,COG2010@2|Bacteria,1N226@1224|Proteobacteria,2VUDD@28216|Betaproteobacteria,2KYYU@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_1110758_1 1122951.ATUE01000005_gene1881 8.65e-67 226.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,3NK2H@468|Moraxellaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_255547_2 1121920.AUAU01000008_gene1682 1.46e-45 152.0 COG1670@1|root,COG1670@2|Bacteria,3Y8PA@57723|Acidobacteria 57723|Acidobacteria J Acetyltransferase (GNAT) domain - - - ko:K03817 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_217912_1 1000565.METUNv1_00580 4.84e-39 138.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2WGFK@28216|Betaproteobacteria,2KVHK@206389|Rhodocyclales 206389|Rhodocyclales C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_217912_2 1000565.METUNv1_00581 4.15e-37 134.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria 28216|Betaproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_507527_1 1000565.METUNv1_03763 1.56e-183 520.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,2KVNW@206389|Rhodocyclales 206389|Rhodocyclales H Capsular polysaccharide biosynthesis protein CapK - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_436163_1 1000565.METUNv1_00496 6.84e-56 197.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,2KUDV@206389|Rhodocyclales 206389|Rhodocyclales P COG0474 Cation transport ATPase - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_436163_2 1163617.SCD_n02805 1.76e-96 297.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2VKXB@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the alkaline phosphatase family phoA2 - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_186113_1 1502770.JQMG01000001_gene1431 4.22e-60 194.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VNMF@28216|Betaproteobacteria 28216|Betaproteobacteria KT HD domain - - - - - - - - - - - - HD k59_255551_1 1123261.AXDW01000001_gene1393 3.72e-43 154.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,1S4XC@1236|Gammaproteobacteria,1X548@135614|Xanthomonadales 135614|Xanthomonadales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_1078842_1 1268622.AVS7_01695 6.36e-129 380.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,4AA39@80864|Comamonadaceae 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_76592_1 1122604.JONR01000057_gene3541 3.15e-92 281.0 COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1X5BD@135614|Xanthomonadales 135614|Xanthomonadales S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_76592_2 1117647.M5M_18450 5.07e-08 53.9 COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,1S3JK@1236|Gammaproteobacteria,1JAEP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_1078843_1 1158292.JPOE01000002_gene2761 7.33e-109 333.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,1KJ9F@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_328911_2 1198452.Jab_2c19950 1.04e-71 216.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,474JW@75682|Oxalobacteraceae 28216|Betaproteobacteria C Succinate dehydrogenase/Fumarate reductase transmembrane subunit sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_826317_1 987059.RBXJA2T_01090 6.46e-09 58.2 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,1KK5W@119065|unclassified Burkholderiales 28216|Betaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_255567_1 3712.Bo00805s050.1 1.5e-12 66.2 2DF3V@1|root,2S5RJ@2759|Eukaryota,380I7@33090|Viridiplantae,3GWU7@35493|Streptophyta,3I10B@3699|Brassicales 35493|Streptophyta - - - - - - - - - - - - - - - k59_507557_2 9593.ENSGGOP00000023679 9.18e-15 79.7 KOG3689@1|root,KOG3689@2759|Eukaryota,38BQB@33154|Opisthokonta,3B9XB@33208|Metazoa,3CSEF@33213|Bilateria,4803J@7711|Chordata,48WDZ@7742|Vertebrata,3J43S@40674|Mammalia,35HXU@314146|Euarchontoglires,4MHPZ@9443|Primates,4N374@9604|Hominidae 33208|Metazoa F GAF domain PDE5A GO:0000166,GO:0001666,GO:0001932,GO:0001934,GO:0002026,GO:0002237,GO:0002676,GO:0002678,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003008,GO:0003012,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006937,GO:0006942,GO:0006950,GO:0007162,GO:0007275,GO:0007399,GO:0007610,GO:0007611,GO:0007613,GO:0007614,GO:0008015,GO:0008016,GO:0008081,GO:0008150,GO:0008152,GO:0008277,GO:0008285,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009187,GO:0009214,GO:0009259,GO:0009261,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009719,GO:0009725,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010562,GO:0010604,GO:0010611,GO:0010613,GO:0010646,GO:0010647,GO:0010720,GO:0010941,GO:0010942,GO:0014070,GO:0014742,GO:0014743,GO:0016787,GO:0016788,GO:0017076,GO:0018130,GO:0019001,GO:0019220,GO:0019222,GO:0019229,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0022407,GO:0022408,GO:0023051,GO:0023056,GO:0030155,GO:0030551,GO:0030553,GO:0031323,GO:0031325,GO:0031347,GO:0031349,GO:0031399,GO:0031401,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032561,GO:0032944,GO:0032945,GO:0033574,GO:0033674,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035150,GO:0035296,GO:0036094,GO:0036293,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042311,GO:0042325,GO:0042327,GO:0042578,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043167,GO:0043168,GO:0043207,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043502,GO:0043549,GO:0043900,GO:0043902,GO:0044057,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045745,GO:0045822,GO:0045859,GO:0045860,GO:0045907,GO:0045932,GO:0045937,GO:0045988,GO:0046058,GO:0046068,GO:0046069,GO:0046434,GO:0046483,GO:0046700,GO:0047555,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0050670,GO:0050672,GO:0050727,GO:0050729,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050880,GO:0050890,GO:0050896,GO:0051094,GO:0051171,GO:0051173,GO:0051174,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051249,GO:0051250,GO:0051338,GO:0051347,GO:0051704,GO:0051707,GO:0055086,GO:0055117,GO:0055118,GO:0055119,GO:0060255,GO:0060281,GO:0060282,GO:0060284,GO:0065007,GO:0065008,GO:0065009,GO:0070482,GO:0070663,GO:0070664,GO:0071704,GO:0071900,GO:0071902,GO:0072521,GO:0072523,GO:0080090,GO:0080134,GO:0090066,GO:0090075,GO:0090257,GO:0097159,GO:0097367,GO:0097746,GO:0097755,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901654,GO:1901700,GO:1902531,GO:1902533,GO:1903037,GO:1903038,GO:1903522,GO:1903523,GO:1903524,GO:1905879,GO:1905881,GO:2000241,GO:2000243 3.1.4.17,3.1.4.35 ko:K13298,ko:K13762 ko00230,ko04022,ko04934,ko05032,map00230,map04022,map04934,map05032 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - GAF,PDEase_I k59_362668_1 1538295.JY96_04195 9.58e-109 330.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHKK@28216|Betaproteobacteria,1KK8A@119065|unclassified Burkholderiales 28216|Betaproteobacteria EGP Transporter proP_2 - - - - - - - - - - - Sugar_tr k59_860905_1 1000565.METUNv1_00827 8.4e-73 226.0 COG2203@1|root,COG2203@2|Bacteria,1RG7F@1224|Proteobacteria,2VUF7@28216|Betaproteobacteria 28216|Betaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2 k59_860905_2 1001585.MDS_0391 3.94e-36 127.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1YG9X@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_682448_1 1000565.METUNv1_03441 0.0 899.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUHI@206389|Rhodocyclales 28216|Betaproteobacteria G PQQ-like domain - - - - - - - - - - - - PQQ,PQQ_2 k59_682448_2 1000565.METUNv1_03440 5.89e-86 258.0 COG1670@1|root,COG1670@2|Bacteria,1PZTX@1224|Proteobacteria,2W4BT@28216|Betaproteobacteria 28216|Betaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_682448_3 1123367.C666_10205 4.31e-104 322.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VM93@28216|Betaproteobacteria,2KXZC@206389|Rhodocyclales 206389|Rhodocyclales NT Pfam:Cache_1 - - - - - - - - - - - - HAMP,MCPsignal,dCache_1 k59_112657_1 420662.Mpe_A3446 1.73e-123 371.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1KJ5X@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_652322_1 882.DVU_0723 1.27e-115 342.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,42MYW@68525|delta/epsilon subdivisions,2WJD1@28221|Deltaproteobacteria,2M9TR@213115|Desulfovibrionales 28221|Deltaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh_C,ATP-grasp,Epimerase k59_256652_1 887062.HGR_06721 6.72e-60 197.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,4AAKQ@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_256652_2 614083.AWQR01000009_gene625 2.06e-33 127.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,4A9NV@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_204322_1 1000565.METUNv1_02986 2.69e-10 59.7 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,2KU6W@206389|Rhodocyclales 206389|Rhodocyclales J ribonuclease, Rne Rng family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_204322_2 1000565.METUNv1_02984 1.03e-52 169.0 COG3339@1|root,COG3339@2|Bacteria,1PH3J@1224|Proteobacteria,2W9DS@28216|Betaproteobacteria,2KZDR@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_455003_1 1122179.KB890416_gene2728 9.27e-26 111.0 COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1IQYI@117747|Sphingobacteriia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,SdrD_B,SprB k59_551311_1 426114.THI_1388 3.13e-78 253.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1KJKD@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_837969_2 1123255.JHYS01000011_gene1276 3.9e-99 304.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,4AAW4@80864|Comamonadaceae 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1092945_1 886293.Sinac_7111 5.17e-108 340.0 COG2010@1|root,COG2010@2|Bacteria,2IYDW@203682|Planctomycetes 203682|Planctomycetes C Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3,PSCyt1,PSCyt2,PSD1 k59_1017904_1 1000565.METUNv1_03820 4.88e-104 324.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales 206389|Rhodocyclales P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_457808_1 159087.Daro_1289 4.25e-93 273.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria,2KW7D@206389|Rhodocyclales 206389|Rhodocyclales C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_161178_1 640511.BC1002_7070 1.95e-29 115.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1K4GQ@119060|Burkholderiaceae 28216|Betaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_161178_2 1562701.BBOF01000060_gene1736 1.14e-20 89.7 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1K4GQ@119060|Burkholderiaceae 28216|Betaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_764929_1 1395571.TMS3_0118645 5.06e-19 92.4 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_943134_1 614083.AWQR01000051_gene3433 6.84e-99 297.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,4A9Z0@80864|Comamonadaceae 28216|Betaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K02346,ko:K03502 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_694936_1 1276756.AUEX01000020_gene3417 2.37e-26 108.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,4A9N2@80864|Comamonadaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_694936_2 1276756.AUEX01000020_gene3416 5.29e-38 136.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,4AB5K@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_980300_2 1123399.AQVE01000057_gene317 2.77e-22 96.7 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - RHS_repeat k59_529213_1 1000565.METUNv1_02022 8.6e-62 207.0 COG2199@1|root,COG2199@2|Bacteria,1R3R8@1224|Proteobacteria,2VJND@28216|Betaproteobacteria,2KWP3@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1056756_1 909663.KI867150_gene1904 3.4e-33 132.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein mcp34H-3 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_269596_1 365044.Pnap_0802 1.98e-93 290.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,4A9RF@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_1122446_1 768671.ThimaDRAFT_2333 1.8e-52 187.0 COG0642@1|root,COG2203@1|root,COG4564@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4564@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X2SE@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - CBS,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_764945_1 1356852.N008_18160 3.1e-107 318.0 COG0482@1|root,COG0482@2|Bacteria,4NFXZ@976|Bacteroidetes,47KX3@768503|Cytophagia 976|Bacteroidetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_207036_1 1121033.AUCF01000033_gene3620 6.12e-08 51.2 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,2JTV5@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_307009_1 1000565.METUNv1_00145 4.34e-135 399.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,2KUNQ@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_875036_1 365044.Pnap_2980 2.45e-20 93.2 2CEXV@1|root,32S0S@2|Bacteria,1MZKB@1224|Proteobacteria,2VU8J@28216|Betaproteobacteria,4AF1Y@80864|Comamonadaceae 28216|Betaproteobacteria S Type II secretion system protein B gspB - - ko:K02451 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - T2SSB k59_483431_1 76114.ebA2664 9.48e-68 215.0 COG4643@1|root,COG4643@2|Bacteria,1MW9E@1224|Proteobacteria,2VKFM@28216|Betaproteobacteria,2KVKJ@206389|Rhodocyclales 206389|Rhodocyclales S Zinc-binding domain of primase-helicase - - - ko:K06919 - - - - ko00000 - - - Prim_Zn_Ribbon,Toprim_3 k59_457880_1 365044.Pnap_4589 5.6e-161 466.0 2DB95@1|root,2Z7UM@2|Bacteria,1MX5I@1224|Proteobacteria,2VMZ7@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_764960_1 1000565.METUNv1_01605 1.06e-221 619.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,2KW7P@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_228561_1 1487953.JMKF01000022_gene2522 2.4e-23 99.4 COG1216@1|root,COG1216@2|Bacteria,1G5W4@1117|Cyanobacteria,1HEDF@1150|Oscillatoriales 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_228561_2 864051.BurJ1DRAFT_1274 2.82e-45 162.0 2DX0P@1|root,342US@2|Bacteria,1NYIZ@1224|Proteobacteria,2W3PE@28216|Betaproteobacteria 28216|Betaproteobacteria I O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_731516_1 207954.MED92_01931 4.28e-13 76.6 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1XMX0@135619|Oceanospirillales 135619|Oceanospirillales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1092991_1 29581.BW37_03050 1.38e-29 117.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2W0VY@28216|Betaproteobacteria,476X8@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1056818_1 153721.MYP_1678 2.64e-20 91.3 COG4083@1|root,COG4083@2|Bacteria,4NM52@976|Bacteroidetes,47SA3@768503|Cytophagia 976|Bacteroidetes S Transmembrane exosortase (Exosortase_EpsH) groEL - - - - - - - - - - - Exosortase_EpsH k59_377294_1 269799.Gmet_1046 1.35e-19 87.4 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,43TBJ@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K13954 ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R04880,R05233,R05234,R06917,R06927 RC00050,RC00088,RC00099,RC00116,RC00649 ko00000,ko00001,ko01000 - - - Fe-ADH k59_18160_1 159450.NH14_04745 2.07e-27 113.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,1JZMW@119060|Burkholderiaceae 28216|Betaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_529294_1 358220.C380_05415 1.2e-80 249.0 COG3203@1|root,COG3203@2|Bacteria,1R8YD@1224|Proteobacteria,2VNCH@28216|Betaproteobacteria,4ABMG@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM porin Gram-negative type - - - - - - - - - - - - Porin_4 k59_269653_2 1000565.METUNv1_02153 5.35e-26 108.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KYID@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_89383_1 1439940.BAY1663_00947 2.23e-51 171.0 2DV6R@1|root,33UCT@2|Bacteria,1NV59@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_529310_1 157783.LK03_01590 8.88e-54 174.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component mlaD GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008289,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_553490_1 1000565.METUNv1_03767 3.1e-20 89.7 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase group 1 - - - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1,Kdo k59_553490_2 1000565.METUNv1_03766 9.32e-52 181.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,2VJKQ@28216|Betaproteobacteria,2KV2F@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_89387_1 614083.AWQR01000005_gene1143 1.86e-128 372.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,4AAM9@80864|Comamonadaceae 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase rfaE - 2.7.1.167,2.7.7.70 ko:K03272,ko:K21344 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_620088_1 159087.Daro_1403 2.68e-11 69.3 COG0653@1|root,COG0653@2|Bacteria,1QWG7@1224|Proteobacteria,2VPIK@28216|Betaproteobacteria,2KZPW@206389|Rhodocyclales 206389|Rhodocyclales U Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_553500_1 748247.AZKH_p0158 7.37e-158 448.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VJFX@28216|Betaproteobacteria,2KX50@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_875092_1 314278.NB231_05100 1.27e-109 328.0 COG0846@1|root,COG0846@2|Bacteria,1R4TQ@1224|Proteobacteria 1224|Proteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_483490_1 1123504.JQKD01000018_gene2020 1.35e-08 54.7 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,4A9JJ@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_483490_2 1223521.BBJX01000009_gene1211 5.12e-108 320.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,4A9UK@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_307090_1 1150626.PHAMO_180128 3.24e-10 65.9 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_228605_1 748247.AZKH_0561 1.27e-87 276.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,2KVFW@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase/oxoprolinase N-terminal region acxA - 6.4.1.6 ko:K10855 - - - - ko00000,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_620099_1 685778.AORL01000010_gene2794 5.64e-07 50.8 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,2K0W3@204457|Sphingomonadales 204457|Sphingomonadales M Cell wall formation ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_620099_2 414684.RC1_0610 3.05e-56 184.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,2JPRS@204441|Rhodospirillales 204441|Rhodospirillales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_89426_1 1454004.AW11_03341 7.35e-15 74.3 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VQEB@28216|Betaproteobacteria,1KQW9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_89429_1 1121035.AUCH01000017_gene2293 1.47e-42 147.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,2KUS0@206389|Rhodocyclales 206389|Rhodocyclales M UTP-glucose-1-phosphate uridylyltransferase epsT - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_89429_2 640081.Dsui_2699 6.89e-44 147.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,2KVMU@206389|Rhodocyclales 206389|Rhodocyclales F phosphoribosyltransferase - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_980412_2 509635.N824_20645 2.74e-19 86.3 COG2197@1|root,COG2197@2|Bacteria,4PI9E@976|Bacteroidetes,1IV96@117747|Sphingobacteriia 976|Bacteroidetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_943235_1 1244869.H261_06766 1.45e-74 241.0 COG4251@1|root,COG4251@2|Bacteria,1R2Y9@1224|Proteobacteria,2TZTH@28211|Alphaproteobacteria,2JZ6B@204441|Rhodospirillales 2|Bacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Protoglobin,Response_reg,dCache_1 k59_695057_1 1144342.PMI40_02678 1.44e-33 130.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,473VR@75682|Oxalobacteraceae 28216|Betaproteobacteria NT PFAM HAMP domain, Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH,sCache_2 k59_695057_2 543728.Vapar_1208 1.53e-18 84.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,4ABP4@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM phosphoesterase, RecJ domain protein recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_586072_1 535289.Dtpsy_1230 1.5e-73 234.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,4AC8F@80864|Comamonadaceae 28216|Betaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_377376_1 929713.NIASO_01565 7.25e-83 265.0 COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,4NDUN@976|Bacteroidetes,1IPSI@117747|Sphingobacteriia 976|Bacteroidetes G Glucosamine-6-phosphate nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L k59_18246_2 1096546.WYO_2788 8.9e-12 65.5 COG2602@1|root,COG2602@2|Bacteria,1NWXE@1224|Proteobacteria,2TTNH@28211|Alphaproteobacteria,1JXNA@119045|Methylobacteriaceae 28211|Alphaproteobacteria V Penicillin binding protein transpeptidase domain bla - 3.5.2.6 ko:K17838 ko01501,map01501 - R06363 RC01499 ko00000,ko00001,ko01000 - - - Transpeptidase k59_672663_1 640081.Dsui_1453 3.28e-14 70.1 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,2KUER@206389|Rhodocyclales 206389|Rhodocyclales S cAMP phosphodiesterases class-II - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_672663_2 1122212.AULO01000007_gene2358 5.69e-31 124.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1XR34@135619|Oceanospirillales 135619|Oceanospirillales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_18250_1 555778.Hneap_0712 1.28e-19 90.1 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1WWVK@135613|Chromatiales 135613|Chromatiales N Role in flagellar biosynthesis - - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_765041_1 762376.AXYL_01855 1.75e-107 324.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VIGJ@28216|Betaproteobacteria,3T3G5@506|Alcaligenaceae 28216|Betaproteobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_125196_1 1123504.JQKD01000009_gene2256 6.17e-88 270.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2VKQE@28216|Betaproteobacteria,4A9VE@80864|Comamonadaceae 28216|Betaproteobacteria I Fatty acid desaturase - - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_89472_1 869213.JCM21142_72763 8.13e-24 101.0 COG0539@1|root,COG0539@2|Bacteria,4NDW9@976|Bacteroidetes,47JD4@768503|Cytophagia 976|Bacteroidetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_672669_1 572477.Alvin_1887 3.05e-60 198.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales 135613|Chromatiales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_307166_1 305700.B447_18828 2e-30 120.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_350651_1 395494.Galf_0682 7.27e-90 296.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,44VA1@713636|Nitrosomonadales 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE k59_1093056_1 1454004.AW11_01181 3.85e-144 419.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,1KPT5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_731615_1 1198452.Jab_2c33640 6.15e-94 285.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VIZB@28216|Betaproteobacteria,475CC@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltT - - - - - - - - - - - SDF k59_672682_1 1121033.AUCF01000003_gene3029 2.45e-147 426.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2JQ38@204441|Rhodospirillales 204441|Rhodospirillales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_805193_1 1122951.ATUE01000006_gene1315 4.49e-98 297.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,3NIZU@468|Moraxellaceae 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_18270_1 543728.Vapar_5778 5.14e-114 332.0 COG0500@1|root,COG2226@2|Bacteria,1PG85@1224|Proteobacteria,2WC4M@28216|Betaproteobacteria,4AIUN@80864|Comamonadaceae 28216|Betaproteobacteria H ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_54636_1 296591.Bpro_2826 4.32e-89 276.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,4AA19@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA - - ko:K07799 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_715100_2 614083.AWQR01000018_gene1807 3.9e-07 50.8 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,4AB2A@80864|Comamonadaceae 28216|Betaproteobacteria KLT HDOD domain - - - - - - - - - - - - HDOD,Pkinase k59_286717_2 991905.SL003B_0891 1.07e-27 112.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BPW2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V ABC transporter transmembrane region msbA2 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_964588_1 656024.FsymDg_2397 2.03e-16 80.5 COG1132@1|root,COG1132@2|Bacteria,2GJTA@201174|Actinobacteria,4EUK2@85013|Frankiales 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_429767_1 338969.Rfer_3035 2.47e-105 327.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,4AAM8@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_429767_2 398578.Daci_5332 5.78e-16 75.5 COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,2VJMM@28216|Betaproteobacteria,4AAG3@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides guaC - 1.7.1.7 ko:K00364 ko00230,map00230 - R01134 RC00457 ko00000,ko00001,ko01000 - - - IMPDH k59_1072329_1 1000565.METUNv1_00581 1.56e-110 327.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria 28216|Betaproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_143807_1 535289.Dtpsy_3012 4.32e-29 110.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,4ABCD@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_143807_2 402626.Rpic_2640 3e-108 320.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,1K1EZ@119060|Burkholderiaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_72250_1 266264.Rmet_4734 2.1e-12 66.6 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1K0EB@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM D-galactarate dehydratase Altronate hydrolase domain protein garD - 4.2.1.42,4.4.1.24 ko:K01708,ko:K16846 ko00053,ko00270,map00053,map00270 - R05608,R07633 RC00543,RC01785 ko00000,ko00001,ko01000 - - - GD_AH_C,SAF k59_1107475_1 1000565.METUNv1_02735 1.88e-196 546.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,2KV1N@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the cysteine synthase cystathionine beta- synthase family cysM - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_322752_1 1000565.METUNv1_00877 9.48e-181 513.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,2KVKS@206389|Rhodocyclales 206389|Rhodocyclales C D-amino acid dehydrogenase dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_215062_1 1353529.M899_0025 3.63e-13 67.0 COG0839@1|root,COG0839@2|Bacteria,1PJW9@1224|Proteobacteria,42V0F@68525|delta/epsilon subdivisions,2MUQ5@213481|Bdellovibrionales,2WS8G@28221|Deltaproteobacteria 213481|Bdellovibrionales C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_215062_2 1201288.M900_0097 9.31e-43 142.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2MTDF@213481|Bdellovibrionales,2WRE5@28221|Deltaproteobacteria 213481|Bdellovibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_215062_3 1353529.M899_0027 4.35e-60 204.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2MSUA@213481|Bdellovibrionales,2WIPT@28221|Deltaproteobacteria 213481|Bdellovibrionales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-2 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_821961_1 1276756.AUEX01000019_gene3423 2.87e-92 277.0 COG2981@1|root,COG2981@2|Bacteria,1Q181@1224|Proteobacteria,2VN29@28216|Betaproteobacteria,4AB0N@80864|Comamonadaceae 28216|Betaproteobacteria E Etoposide-induced protein 2.4 (EI24) - - - - - - - - - - - - EI24 k59_857437_1 1000565.METUNv1_03367 7.28e-115 335.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KVA0@206389|Rhodocyclales 206389|Rhodocyclales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_857437_3 1000565.METUNv1_03369 2.05e-41 142.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,2KWEK@206389|Rhodocyclales 206389|Rhodocyclales C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_857437_4 1000565.METUNv1_03370 3.16e-98 288.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2VSJV@28216|Betaproteobacteria,2KWKN@206389|Rhodocyclales 206389|Rhodocyclales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_857437_5 265072.Mfla_2746 5.1e-112 336.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,2KKGG@206350|Nitrosomonadales 206350|Nitrosomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_429796_2 391038.Bphy_4452 1.02e-17 81.6 COG2207@1|root,COG2207@2|Bacteria,1R9DC@1224|Proteobacteria,2WEIM@28216|Betaproteobacteria,1KHVJ@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - AraC_binding,HTH_18 k59_36840_1 159087.Daro_3549 4.27e-207 619.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_429807_1 1000565.METUNv1_02648 2.66e-189 532.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2VJAZ@28216|Betaproteobacteria,2KV45@206389|Rhodocyclales 206389|Rhodocyclales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_108048_1 323848.Nmul_A0256 1.42e-91 278.0 COG0673@1|root,COG0673@2|Bacteria,1PE87@1224|Proteobacteria,2W9B1@28216|Betaproteobacteria,374HB@32003|Nitrosomonadales 28216|Betaproteobacteria C Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_1107491_1 1000565.METUNv1_00036 4.88e-128 365.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,2KV8X@206389|Rhodocyclales 206389|Rhodocyclales O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1107491_2 1000565.METUNv1_00037 6.24e-245 676.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,2KVAQ@206389|Rhodocyclales 206389|Rhodocyclales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_179954_1 1000565.METUNv1_02872 1.1e-212 595.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,2KUDF@206389|Rhodocyclales 206389|Rhodocyclales L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C k59_179954_2 1000565.METUNv1_02873 3.43e-37 127.0 2EB0P@1|root,330T4@2|Bacteria,1N6DJ@1224|Proteobacteria,2VURK@28216|Betaproteobacteria,2KX52@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_179954_3 1000565.METUNv1_02874 8.62e-194 545.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,2KV4N@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_536300_1 323848.Nmul_A1689 6.33e-68 219.0 COG4242@1|root,COG4242@2|Bacteria,1R5TW@1224|Proteobacteria,2VPUA@28216|Betaproteobacteria 28216|Betaproteobacteria PQ Peptidase family S51 - - - - - - - - - - - - Peptidase_S51 k59_537002_1 522306.CAP2UW1_4467 1.03e-80 249.0 COG0559@1|root,COG0559@2|Bacteria,1MXMC@1224|Proteobacteria,2VJ1Y@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_537002_2 1304883.KI912532_gene937 7.59e-46 165.0 COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,2KUY7@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_359162_1 1095769.CAHF01000011_gene2418 2.9e-125 369.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4734P@75682|Oxalobacteraceae 28216|Betaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain odhL GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_324006_1 76114.ebA3111 7.61e-32 121.0 COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,2VIRA@28216|Betaproteobacteria,2KWT2@206389|Rhodocyclales 206389|Rhodocyclales L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C k59_894396_1 556269.ACDQ01000006_gene1656 9.14e-25 97.4 2E7TE@1|root,3328J@2|Bacteria,1N6RC@1224|Proteobacteria,2VX0Z@28216|Betaproteobacteria,477Y1@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - BrnA_antitoxin k59_894396_2 864073.HFRIS_004308 2.25e-14 67.4 2E722@1|root,331KP@2|Bacteria,1N7HW@1224|Proteobacteria,2W5PM@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_572631_1 1000565.METUNv1_01533 1.66e-114 339.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,2KUJY@206389|Rhodocyclales 206389|Rhodocyclales G Phosphoglucomutase - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_572633_1 1000565.METUNv1_02759 6.82e-73 239.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_430998_1 1000565.METUNv1_00353 7.37e-140 409.0 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,2KUGG@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17 k59_965337_2 614083.AWQR01000005_gene1117 5.66e-107 322.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4AB5M@80864|Comamonadaceae 28216|Betaproteobacteria T TIGRFAM nitrogen regulation protein NR(I) ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1926_1 666681.M301_0878 3.76e-15 76.3 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,2KM7U@206350|Nitrosomonadales 206350|Nitrosomonadales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_144566_1 1042209.HK44_023830 1.08e-108 324.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1YSS1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family intA - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_894400_2 1000565.METUNv1_03409 5.54e-150 429.0 COG4977@1|root,COG4977@2|Bacteria,1MXZQ@1224|Proteobacteria,2WHBR@28216|Betaproteobacteria,2KX7A@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_537004_2 1000565.METUNv1_03818 4.84e-251 697.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,2KV54@206389|Rhodocyclales 206389|Rhodocyclales M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_822783_1 395495.Lcho_1248 2.42e-82 258.0 COG0415@1|root,COG0415@2|Bacteria,1MX6J@1224|Proteobacteria,2VK7R@28216|Betaproteobacteria,1KNC4@119065|unclassified Burkholderiales 28216|Betaproteobacteria H DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1001200_1 595537.Varpa_3391 2.68e-97 298.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,4AA7T@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_394783_1 1000565.METUNv1_00809 5.44e-199 555.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,2KUVD@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_72941_1 1121447.JONL01000005_gene1576 9.54e-12 71.2 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2M7R7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1037220_2 1000565.METUNv1_00993 1.7e-153 488.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_822791_1 1005048.CFU_3603 2.37e-26 114.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,472QP@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_252012_1 1000565.METUNv1_03652 0.000102 43.5 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,2KW7R@206389|Rhodocyclales 206389|Rhodocyclales H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_252012_2 1000565.METUNv1_03651 6.27e-193 542.0 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,2KUGQ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1073659_1 1100721.ALKO01000021_gene778 1.96e-30 123.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,4AAEI@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM peptidase M16 domain protein - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_679784_1 583355.Caka_1404 1.44e-67 214.0 COG1119@1|root,COG1119@2|Bacteria,46SN3@74201|Verrucomicrobia,3K7YG@414999|Opitutae 414999|Opitutae P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_431027_1 1122951.ATUE01000008_gene61 5.42e-67 212.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,3NJ01@468|Moraxellaceae 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_431027_2 1120925.F941_00139 3.65e-07 52.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,3NK5E@468|Moraxellaceae 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1108233_2 272568.GDI2279 1.26e-18 82.8 COG1028@1|root,COG1028@2|Bacteria,1MW4W@1224|Proteobacteria,2U5N0@28211|Alphaproteobacteria,2JSWE@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short k59_359201_1 1000565.METUNv1_02872 1.31e-34 129.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,2KUDF@206389|Rhodocyclales 206389|Rhodocyclales L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C k59_359201_2 1000565.METUNv1_02871 1.72e-41 141.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,2KWH0@206389|Rhodocyclales 206389|Rhodocyclales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_787530_1 1353529.M899_0659 4.09e-33 131.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,43BMJ@68525|delta/epsilon subdivisions,2MTH6@213481|Bdellovibrionales,2WUEV@28221|Deltaproteobacteria 213481|Bdellovibrionales T Response regulator receiver - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,Response_reg k59_894417_1 45157.CMJ211CT 5.38e-19 85.5 COG0649@1|root,KOG2870@2759|Eukaryota 2759|Eukaryota C quinone binding NDUFS2 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0005759,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010257,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019899,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031625,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070013,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K03935,ko:K06669 ko00190,ko01100,ko04110,ko04111,ko04113,ko04114,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04110,map04111,map04113,map04114,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko00535,ko01000,ko03036 3.D.1.6 - - Complex1_49kDa k59_894417_4 4787.PITG_23229T0 9.18e-42 161.0 COG1007@1|root,KOG4668@2759|Eukaryota 2759|Eukaryota C NADH dehydrogenase (quinone) activity ND2 GO:0003674,GO:0003824,GO:0003954,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010257,GO:0014069,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032279,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0035254,GO:0035255,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044456,GO:0044464,GO:0045202,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0072593,GO:0097458,GO:0098794,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0098984,GO:0099572,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K03879 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - NADH_dehy_S2_C,Proton_antipo_M k59_181180_1 266264.Rmet_0192 3.02e-39 152.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,1KBUP@119060|Burkholderiaceae 28216|Betaproteobacteria NU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_108889_1 1000565.METUNv1_00796 2.23e-92 276.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria,2KVHJ@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_108889_2 1000565.METUNv1_00798 3.63e-52 172.0 COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,2KVQX@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_716130_1 1000565.METUNv1_01944 5.07e-70 214.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,2KWHZ@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_716130_2 1000565.METUNv1_01943 2.76e-285 796.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales 206389|Rhodocyclales U Type 4 fimbrial biogenesis protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_858224_1 1000565.METUNv1_02922 9.06e-53 169.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,2KWB7@206389|Rhodocyclales 206389|Rhodocyclales J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_645323_3 323848.Nmul_A1463 6.56e-98 306.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2VN61@28216|Betaproteobacteria,372UI@32003|Nitrosomonadales 28216|Betaproteobacteria S Phage terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_645323_6 1269813.ATUL01000006_gene1825 4.57e-30 109.0 2CH99@1|root,32S5M@2|Bacteria,1N2GH@1224|Proteobacteria 1224|Proteobacteria S Recombination enhancement, RecA-dependent nuclease - - - - - - - - - - - - RecA_dep_nuc k59_645323_7 1122201.AUAZ01000021_gene3139 2.08e-38 135.0 2CJKM@1|root,314EI@2|Bacteria,1RGVN@1224|Proteobacteria,1T082@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_894433_1 1198452.Jab_2c18070 2.05e-92 284.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2WGJC@28216|Betaproteobacteria,473G2@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_324083_1 887062.HGR_16650 1.25e-23 100.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,4AATG@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar basal body rod protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_324083_2 338969.Rfer_3716 7.77e-27 105.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2VSF6@28216|Betaproteobacteria,4AEAR@80864|Comamonadaceae 28216|Betaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_359226_1 1500894.JQNN01000001_gene1082 1.21e-12 67.4 COG1402@1|root,COG1402@2|Bacteria,1R4JB@1224|Proteobacteria,2VQJZ@28216|Betaproteobacteria,4740M@75682|Oxalobacteraceae 28216|Betaproteobacteria S Creatinine amidohydrolase - - - - - - - - - - - - Creatininase k59_359226_2 1382230.ASAP_2411 1.24e-28 114.0 COG3391@1|root,COG3391@2|Bacteria,1R78P@1224|Proteobacteria,2U3BG@28211|Alphaproteobacteria,2JW9N@204441|Rhodospirillales 204441|Rhodospirillales S amine dehydrogenase activity - - - - - - - - - - - - - k59_215853_1 522373.Smlt4099 3.09e-88 278.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1X43R@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_181195_1 640081.Dsui_0821 2.87e-173 508.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales 206389|Rhodocyclales L DNA topoisomerase III - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k59_181195_2 640081.Dsui_0820 1.96e-14 70.1 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,2KWJJ@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_894440_1 583345.Mmol_1923 8.55e-82 264.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VP67@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase with PAS PAC - - - - - - - - - - - - GAF_2,GGDEF,PAS_3 k59_579984_1 1198452.Jab_2c24930 1.47e-130 379.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,472Q2@75682|Oxalobacteraceae 28216|Betaproteobacteria I Transposase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_1115637_1 1121920.AUAU01000004_gene642 2.38e-111 343.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria 57723|Acidobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_298242_1 358220.C380_19400 2.08e-145 418.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VJNE@28216|Betaproteobacteria,4ACWM@80864|Comamonadaceae 28216|Betaproteobacteria C Homoaconitate hydratase family protein - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_153512_1 1000565.METUNv1_03407 6.93e-24 100.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VHFH@28216|Betaproteobacteria,2KYAN@206389|Rhodocyclales 206389|Rhodocyclales C Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like k59_1115638_1 588596.U9TMA1 1.87e-05 52.4 COG0515@1|root,KOG0192@2759|Eukaryota 2759|Eukaryota KLT protein kinase activity - - - - - - - - - - - - Pkinase_Tyr k59_614222_1 1121035.AUCH01000025_gene3308 3.23e-92 298.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,2KUP6@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_261614_1 1000565.METUNv1_02300 1.52e-55 187.0 2E400@1|root,32YWX@2|Bacteria,1N9MA@1224|Proteobacteria,2VWN4@28216|Betaproteobacteria,2KX5G@206389|Rhodocyclales 206389|Rhodocyclales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_261614_2 1000565.METUNv1_02299 3.78e-58 203.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VPB3@28216|Betaproteobacteria,2KVVY@206389|Rhodocyclales 206389|Rhodocyclales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_4,TPR_8 k59_403710_1 1000565.METUNv1_01512 7.98e-78 233.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,2VJ9U@28216|Betaproteobacteria,2KW51@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S ferredoxin, iron-sulfur binding - - - - - - - - - - - - Fer4,Fer4_11 k59_403710_2 1000565.METUNv1_01514 6.38e-78 234.0 COG2010@1|root,COG2010@2|Bacteria,1RH1S@1224|Proteobacteria,2VQ9Y@28216|Betaproteobacteria,2KWMS@206389|Rhodocyclales 206389|Rhodocyclales C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrome_CBB3 k59_1115644_1 1349767.GJA_1141 2.84e-74 229.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,472K9@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_517113_1 1000565.METUNv1_02805 1.06e-24 94.0 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,2KX9K@206389|Rhodocyclales 206389|Rhodocyclales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_517113_2 1000565.METUNv1_02804 2.49e-55 183.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,2KVAD@206389|Rhodocyclales 206389|Rhodocyclales H Molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1011061_2 675815.VOA_000888 4.63e-17 79.7 COG2834@1|root,COG2834@2|Bacteria,1RE9C@1224|Proteobacteria,1S9F3@1236|Gammaproteobacteria,1XSID@135623|Vibrionales 135623|Vibrionales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1011062_1 1353529.M899_0181 2.36e-74 231.0 COG3745@1|root,COG3745@2|Bacteria,1NDG2@1224|Proteobacteria,42WK8@68525|delta/epsilon subdivisions,2MT5Z@213481|Bdellovibrionales,2WRTY@28221|Deltaproteobacteria 213481|Bdellovibrionales U flp pilus assembly protein CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_475347_1 1121878.AUGL01000002_gene2431 1.29e-50 167.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033692,GO:0034200,GO:0034637,GO:0034645,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046872,GO:0046914,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iB21_1397.B21_00198,iEC55989_1330.EC55989_0198,iECBD_1354.ECBD_3418,iECB_1328.ECB_00199,iECD_1391.ECD_00199,iECIAI1_1343.ECIAI1_0202,iECO103_1326.ECO103_0200,iECSE_1348.ECSE_0202,iETEC_1333.ETEC_0196,iEcHS_1320.EcHS_A0204,iEcolC_1368.EcolC_3459 HAD_2,Hydrolase_like k59_475347_2 269482.Bcep1808_0815 1.06e-53 184.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,1K0NF@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the mannose-6-phosphate isomerase type 2 family manC - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_614230_1 580332.Slit_1948 5.54e-56 190.0 COG4913@1|root,COG4913@2|Bacteria,1QW0C@1224|Proteobacteria,2WHS7@28216|Betaproteobacteria 28216|Betaproteobacteria L TIGRFAM phage-type endonuclease - - - - - - - - - - - - YqaJ k59_1088120_1 1000565.METUNv1_00327 1.19e-55 187.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUM3@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_832785_2 614083.AWQR01000057_gene3659 4.05e-86 264.0 COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2VJ0D@28216|Betaproteobacteria,4ABH3@80864|Comamonadaceae 28216|Betaproteobacteria G PFAM extracellular solute-binding protein family 1 - - - ko:K17315 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - SBP_bac_1 k59_475353_1 1000565.METUNv1_03671 9.53e-10 70.9 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_724488_1 1150626.PHAMO_380098 3.12e-05 49.7 COG0582@1|root,COG0582@2|Bacteria,1RAN4@1224|Proteobacteria,2U47D@28211|Alphaproteobacteria,2JSU9@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_403728_1 397945.Aave_1226 1.58e-185 533.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,4ABI0@80864|Comamonadaceae 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_904225_1 748247.AZKH_1852 0.000597 42.0 COG0477@1|root,COG0477@2|Bacteria,1QU36@1224|Proteobacteria,2W1PI@28216|Betaproteobacteria 28216|Betaproteobacteria EGP Drug resistance transporter Bcr CflA subfamily - - - ko:K07552,ko:K18552 - - - - br01600,ko00000,ko01504,ko02000 2.A.1.2,2.A.1.2.3 - - MFS_1 k59_904225_2 1244869.H261_13589 7.68e-38 138.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2JPGW@204441|Rhodospirillales 204441|Rhodospirillales G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_446275_1 1121898.Q766_05980 7.62e-22 99.4 COG3209@1|root,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia,2NSCF@237|Flavobacterium 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,Laminin_G_3,SprB k59_475369_1 1000565.METUNv1_02098 5.23e-15 72.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,2KWGG@206389|Rhodocyclales 206389|Rhodocyclales S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_475369_2 497321.C664_18242 4.57e-46 157.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_10770_1 1122951.ATUE01000005_gene1808 4.63e-53 181.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,3NK3B@468|Moraxellaceae 1236|Gammaproteobacteria CH FAD binding domain ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R08768,R08773 RC00046,RC02670 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066 FAD_binding_3 k59_662609_1 926562.Oweho_3286 1.68e-41 144.0 COG1514@1|root,COG1514@2|Bacteria,4NTUH@976|Bacteroidetes,1I48G@117743|Flavobacteriia 976|Bacteroidetes J 2',5' RNA ligase - - - - - - - - - - - - 2_5_RNA_ligase2 k59_1116885_1 1201290.M902_2563 3.4e-63 208.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2MSRS@213481|Bdellovibrionales,2WNZJ@28221|Deltaproteobacteria 213481|Bdellovibrionales C 4Fe-4S dicluster domain ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1012149_1 1000565.METUNv1_03393 2.21e-113 328.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,2KV8T@206389|Rhodocyclales 206389|Rhodocyclales U MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_404732_1 1279038.KB907337_gene646 1.59e-98 293.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2JQMV@204441|Rhodospirillales 204441|Rhodospirillales C (Fe-S) oxidoreductase - - - ko:K18928 - - - - ko00000 - - - CCG k59_448268_1 1123377.AUIV01000029_gene639 4.6e-13 72.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1X41Z@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the UPF0301 (AlgH) family algH - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_662647_1 1095769.CAHF01000018_gene812 2.28e-81 254.0 COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,4764U@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC-type Fe3 transport system, periplasmic afuA - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_688756_1 1000565.METUNv1_01320 2.45e-08 53.9 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,2KV36@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_688756_2 1000565.METUNv1_01321 3.1e-154 471.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,2WHG0@28216|Betaproteobacteria 28216|Betaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3 k59_662671_1 644968.DFW101_0896 2.33e-40 157.0 COG0582@1|root,COG0582@2|Bacteria,1R6BF@1224|Proteobacteria,43B4X@68525|delta/epsilon subdivisions,2X6IN@28221|Deltaproteobacteria,2MH3E@213115|Desulfovibrionales 28221|Deltaproteobacteria L Phage integrase SAM-like domain - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase k59_798833_1 1267211.KI669560_gene2545 4.73e-88 273.0 COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,1IPK3@117747|Sphingobacteriia 976|Bacteroidetes E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease,AA_permease_2 k59_798834_1 1097668.BYI23_E002490 5.77e-06 47.0 2CEXV@1|root,32S0S@2|Bacteria,1MZKB@1224|Proteobacteria,2VU8J@28216|Betaproteobacteria,1KBHC@119060|Burkholderiaceae 28216|Betaproteobacteria S Type II secretion system protein B gspB - - ko:K02451 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - T2SSB k59_798834_2 420662.Mpe_A0864 1.57e-38 131.0 COG1917@1|root,COG1917@2|Bacteria,1N0MR@1224|Proteobacteria,2VVE1@28216|Betaproteobacteria,1KMMB@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - AraC_binding,Cupin_2 k59_798834_3 864051.BurJ1DRAFT_3715 3.74e-28 106.0 COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,1KKWK@119065|unclassified Burkholderiales 28216|Betaproteobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1012181_2 686340.Metal_3892 7.61e-53 172.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1SHWC@1236|Gammaproteobacteria,1XE6Z@135618|Methylococcales 135618|Methylococcales K PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal - - - - - - - - - - - - DUF1956,TetR_N k59_759818_1 156578.ATW7_09993 3.37e-60 215.0 COG0584@1|root,COG0737@1|root,COG0584@2|Bacteria,COG0737@2|Bacteria,1NTU5@1224|Proteobacteria,1RR0F@1236|Gammaproteobacteria 1236|Gammaproteobacteria CF COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases - - - - - - - - - - - - Metallophos k59_1012190_1 1177154.Y5S_02050 8.46e-08 53.1 COG3687@1|root,COG3687@2|Bacteria,1R6G1@1224|Proteobacteria,1T089@1236|Gammaproteobacteria,1XJSP@135619|Oceanospirillales 135619|Oceanospirillales S Metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_1012190_2 525244.HMPREF0023_0051 1.11e-36 134.0 COG3687@1|root,COG3687@2|Bacteria,1RDT2@1224|Proteobacteria,1T088@1236|Gammaproteobacteria,3NTFM@468|Moraxellaceae 1236|Gammaproteobacteria S Predicted metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_833983_1 1506583.JQJY01000009_gene1091 1.95e-100 305.0 COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,1I02U@117743|Flavobacteriia,2NSVU@237|Flavobacterium 976|Bacteroidetes E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease,AA_permease_2 k59_1046920_1 1000565.METUNv1_00123 8.57e-131 378.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KVK1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_798850_1 614083.AWQR01000018_gene1844 3.07e-34 126.0 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,2VV2Y@28216|Betaproteobacteria,4AHPP@80864|Comamonadaceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_798850_2 983548.Krodi_2963 5.82e-26 107.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,1HXIJ@117743|Flavobacteriia,37EPY@326319|Dokdonia 976|Bacteroidetes L helicase superfamily c-terminal domain - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_155015_1 1198452.Jab_2c24720 3.69e-114 333.0 COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,4728Z@75682|Oxalobacteraceae 28216|Betaproteobacteria O transport system cysT - - ko:K02046,ko:K15496 ko00920,ko02010,map00920,map02010 M00185,M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.6.5 - - BPD_transp_1 k59_263016_1 1276756.AUEX01000009_gene1723 1.87e-83 254.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,4AAMX@80864|Comamonadaceae 28216|Betaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_263016_2 1123255.JHYS01000012_gene1334 2.79e-08 53.9 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,4A9RB@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein glcD - 1.1.2.4,1.1.3.15,1.1.5.12 ko:K00102,ko:K00104,ko:K03777 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475,R00704,R11591 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_197923_1 864073.HFRIS_009440 5.93e-09 56.2 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria 28216|Betaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_938290_1 864051.BurJ1DRAFT_1274 2.75e-75 246.0 2DX0P@1|root,342US@2|Bacteria,1NYIZ@1224|Proteobacteria,2W3PE@28216|Betaproteobacteria 28216|Betaproteobacteria I O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_938290_2 1502852.FG94_04466 1.07e-20 92.4 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_905265_1 984262.SGRA_2848 3.31e-41 149.0 COG3579@1|root,COG3579@2|Bacteria,4NE02@976|Bacteroidetes,1IQHU@117747|Sphingobacteriia 976|Bacteroidetes E Aminopeptidase pepC - 3.4.22.40 ko:K01372 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C1,Peptidase_C1_2 k59_448383_1 887898.HMPREF0551_2604 3.98e-95 289.0 COG0438@1|root,COG0438@2|Bacteria,1MUYN@1224|Proteobacteria,2VNWP@28216|Betaproteobacteria,1K6XW@119060|Burkholderiaceae 28216|Betaproteobacteria M Domain of unknown function (DUF1972) - - - - - - - - - - - - DUF1972,Glyco_trans_1_2,Glyco_transf_4,Glycos_transf_1 k59_155040_1 1000565.METUNv1_04061 1.04e-94 285.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,2KVUV@206389|Rhodocyclales 206389|Rhodocyclales C formate dehydrogenase fdhC - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_476733_1 1095769.CAHF01000011_gene2174 2.39e-62 208.0 COG2199@1|root,COG3614@1|root,COG2199@2|Bacteria,COG3614@2|Bacteria,1RGCV@1224|Proteobacteria,2WGZP@28216|Betaproteobacteria,47960@75682|Oxalobacteraceae 28216|Betaproteobacteria T CHASE - - - - - - - - - - - - CHASE,GGDEF,PAS_3 k59_1012232_1 296591.Bpro_2956 5.65e-106 314.0 COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2VHIZ@28216|Betaproteobacteria,4A9J1@80864|Comamonadaceae 28216|Betaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_725862_1 640081.Dsui_2928 4.82e-60 194.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,2KVDU@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 transport system, periplasmic component - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_725862_2 640081.Dsui_2942 1.47e-120 361.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 transport system, permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_83678_2 1000565.METUNv1_00116 7.73e-75 253.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,2KW9H@206389|Rhodocyclales 206389|Rhodocyclales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_798905_2 102129.Lepto7375DRAFT_7273 4.89e-25 98.6 2EHVE@1|root,33BKZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_688872_1 1000565.METUNv1_00060 1.56e-97 293.0 COG3291@1|root,COG3291@2|Bacteria,1RFUT@1224|Proteobacteria,2VS7V@28216|Betaproteobacteria 28216|Betaproteobacteria S Pkd domain containing protein - - - - - - - - - - - - Peptidase_M10,VPEP k59_83687_1 1504672.669783001 4.06e-28 104.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,4ADHY@80864|Comamonadaceae 28216|Betaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_63242_2 1000565.METUNv1_00054 1.55e-59 196.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,2KV5M@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,Response_reg k59_279143_1 1000565.METUNv1_03049 1.75e-145 415.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,2KUTM@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_390512_1 1298858.AUEL01000002_gene1735 1.27e-57 202.0 COG0784@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2TXI3@28211|Alphaproteobacteria,43J13@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_318556_1 211165.AJLN01000045_gene270 2.5e-66 221.0 COG3664@1|root,COG3664@2|Bacteria,1GANI@1117|Cyanobacteria 1117|Cyanobacteria G PFAM Glycosyl hydrolases family 39 - - - ko:K21000 ko02025,map02025 - - - ko00000,ko00001 - GH39 - Glyco_hydro_39,Glyco_hydro_cc k59_950922_1 1100720.ALKN01000045_gene202 8.41e-21 89.4 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2WGMM@28216|Betaproteobacteria,4ABPZ@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_950922_2 614083.AWQR01000018_gene1804 1.65e-51 169.0 COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2VH6T@28216|Betaproteobacteria,4ABNG@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family bdhA - 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_99371_1 665571.STHERM_c01540 9.14e-38 145.0 COG3420@1|root,COG4733@1|root,COG3420@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 5.1.3.37 ko:K01795,ko:K20276 ko00051,ko02024,map00051,map02024 - R08693 RC00509 ko00000,ko00001,ko01000 - - - Beta_helix,Big_2,F5_F8_type_C,SLH,TIR_2 k59_494428_1 519989.ECTPHS_05836 1.32e-44 156.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_26977_1 640081.Dsui_1028 1.09e-66 206.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,2KW7T@206389|Rhodocyclales 206389|Rhodocyclales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_26977_2 640081.Dsui_1029 7.93e-50 158.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,2KX13@206389|Rhodocyclales 206389|Rhodocyclales C Ferredoxin - - - - - - - - - - - - Fer4 k59_134402_1 1157708.KB907453_gene4232 7.49e-107 313.0 COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,2VIXH@28216|Betaproteobacteria,4ABEY@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the pseudouridine synthase RsuA family rsuA - 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_318577_1 525373.HMPREF0766_10007 3.07e-56 181.0 292K5@1|root,2ZQ43@2|Bacteria,4NPMT@976|Bacteroidetes,1IYQ4@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_418158_1 194699.PORTL_BPBPP 2.65e-58 197.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_494467_2 1429851.X548_01145 2.7e-05 47.0 COG2916@1|root,COG2916@2|Bacteria,1N801@1224|Proteobacteria,1SJGP@1236|Gammaproteobacteria,1X7K8@135614|Xanthomonadales 135614|Xanthomonadales S dna-binding protein - - - ko:K03746 - - - - ko00000,ko03036,ko03400 - - - Histone_HNS k59_885919_3 176299.Atu1281 5.2e-25 112.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,4B9XK@82115|Rhizobiaceae 28211|Alphaproteobacteria CP NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADH5_C,Proton_antipo_M,Proton_antipo_N k59_950960_1 760192.Halhy_0738 1.82e-134 410.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1IQCW@117747|Sphingobacteriia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_593972_1 1121413.JMKT01000016_gene114 1.04e-34 130.0 COG1216@1|root,COG1216@2|Bacteria,1RGFD@1224|Proteobacteria,42ZI9@68525|delta/epsilon subdivisions,2WUVV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_704028_1 929713.NIASO_20085 6.62e-57 192.0 COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,1IRPS@117747|Sphingobacteriia 976|Bacteroidetes G Putative collagen-binding domain of a collagenase - - - - - - - - - - - - Collagen_bind_2,DUF4038 k59_390619_1 398525.KB900701_gene3874 1.82e-68 221.0 COG0477@1|root,COG0477@2|Bacteria,1QWSX@1224|Proteobacteria,2TX4I@28211|Alphaproteobacteria,3JQPJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Sugar (and other) transporter MA20_07500 - - - - - - - - - - - MFS_1,Sugar_tr k59_564089_1 1123234.AUKI01000016_gene2925 7.6e-08 59.3 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,4NFEF@976|Bacteroidetes,1HXAX@117743|Flavobacteriia 976|Bacteroidetes T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_772686_1 1000565.METUNv1_00709 2.48e-78 236.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VRCR@28216|Betaproteobacteria,2KW89@206389|Rhodocyclales 206389|Rhodocyclales O Bacterial protein of unknown function (DUF899) - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_772686_2 1123392.AQWL01000009_gene1046 7.55e-28 112.0 2FGJC@1|root,348F6@2|Bacteria,1P1CM@1224|Proteobacteria,2W4FI@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - VPEP k59_950970_1 460265.Mnod_1266 1.32e-82 253.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSGN@28211|Alphaproteobacteria,1JTV1@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Binding-protein-dependent transport system inner membrane component ugpA - - ko:K05814 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_134474_1 365044.Pnap_2950 3.97e-13 68.2 COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,4ABK8@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_134474_2 365044.Pnap_2951 2.46e-54 178.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,4AB0U@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_739966_2 1296416.JACB01000017_gene5222 1.43e-21 92.8 COG0037@1|root,COG0037@2|Bacteria,4NIZR@976|Bacteroidetes,1HZ3F@117743|Flavobacteriia,2YJFP@290174|Aquimarina 976|Bacteroidetes D LPS biosynthesis protein - - - - - - - - - - - - NAD_synthase k59_170571_1 497964.CfE428DRAFT_3556 4.54e-76 248.0 COG1185@1|root,COG1185@2|Bacteria,46SBP@74201|Verrucomicrobia 74201|Verrucomicrobia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_99486_1 1000565.METUNv1_00281 3.03e-83 254.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2VH12@28216|Betaproteobacteria,2KV7F@206389|Rhodocyclales 206389|Rhodocyclales P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component nasE - - ko:K15577 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - BPD_transp_1 k59_170584_1 1123261.AXDW01000001_gene990 1.93e-64 208.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,1RZSX@1236|Gammaproteobacteria,1XBXC@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_170584_2 748247.AZKH_p0291 2.06e-36 136.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_950996_1 266265.Bxe_B0305 1.71e-130 385.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1K0R6@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family acoD - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_739998_1 40571.JOEA01000003_gene3591 1.21e-76 236.0 COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales 201174|Actinobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1028376_1 375286.mma_2952 2.16e-70 241.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,473JA@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_63390_1 1122951.ATUE01000006_gene1353 2.8e-63 204.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,3NIHQ@468|Moraxellaceae 1236|Gammaproteobacteria M Bacterial lipid A biosynthesis acyltransferase htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_850902_1 399795.CtesDRAFT_PD0670 4.88e-88 266.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,4ACEU@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_279346_1 1217713.F993_01917 3.33e-114 343.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1TMDS@1236|Gammaproteobacteria,3NMXH@468|Moraxellaceae 1236|Gammaproteobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like,K_oxygenase k59_1131510_1 387093.SUN_1816 1.37e-23 103.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2YN8I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Abc transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_170644_1 1121897.AUGO01000003_gene1848 1.99e-09 58.2 COG0566@1|root,COG0566@2|Bacteria,4NG1U@976|Bacteroidetes,1HY9B@117743|Flavobacteriia,2NS92@237|Flavobacterium 976|Bacteroidetes J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family aviRb - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_815320_1 546266.NEIMUCOT_04582 2.35e-20 83.6 2E32Y@1|root,32Y36@2|Bacteria,1N7G2@1224|Proteobacteria,2VYSF@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_320951_1 614083.AWQR01000005_gene923 2.38e-117 337.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,4ABQK@80864|Comamonadaceae 28216|Betaproteobacteria C cytochrome c oxidase, cbb3-type, subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_320951_2 614083.AWQR01000005_gene922 4.12e-20 80.9 COG4736@1|root,COG4736@2|Bacteria,1PUF6@1224|Proteobacteria,2VXME@28216|Betaproteobacteria,4AFTD@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM Cbb3-type cytochrome oxidase component ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_420449_2 706587.Desti_1390 6.54e-30 107.0 COG3655@1|root,COG3655@2|Bacteria,1N6VH@1224|Proteobacteria,42WD9@68525|delta/epsilon subdivisions,2WRA8@28221|Deltaproteobacteria 28221|Deltaproteobacteria K transcriptional regulator, XRE family - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 k59_420463_1 748247.AZKH_2920 3.3e-05 46.6 COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,2VW6K@28216|Betaproteobacteria,2KXJE@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - - k59_420463_2 748280.NH8B_2212 3.23e-42 151.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,2KTTZ@206351|Neisseriales 206351|Neisseriales P Sugar (and other) transporter - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_566432_1 509190.Cseg_3058 2.39e-11 64.3 COG2207@1|root,COG2207@2|Bacteria,1RJPK@1224|Proteobacteria,2TTNE@28211|Alphaproteobacteria,2KHHG@204458|Caulobacterales 204458|Caulobacterales K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - HTH_18 k59_566432_2 768710.DesyoDRAFT_2856 1.39e-20 91.7 COG1296@1|root,COG1296@2|Bacteria,1TP8P@1239|Firmicutes,248NN@186801|Clostridia,261GY@186807|Peptococcaceae 186801|Clostridia E Branched-chain amino acid permease - - - - - - - - - - - - AzlC k59_497644_1 626887.J057_20000 6.76e-30 124.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,464UD@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_991555_2 1201288.M900_2040 8.36e-25 96.3 COG0023@1|root,COG0023@2|Bacteria,1MZ8T@1224|Proteobacteria,42TW6@68525|delta/epsilon subdivisions,2MTFV@213481|Bdellovibrionales,2WQNT@28221|Deltaproteobacteria 213481|Bdellovibrionales J Translation initiation factor SUI1 yciH - - ko:K03113 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - SUI1 k59_920846_1 440512.C211_10188 1.87e-79 265.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_815368_1 640511.BC1002_0612 4.9e-42 150.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,1K0NF@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the mannose-6-phosphate isomerase type 2 family manC - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_952970_1 269798.CHU_2852 2.61e-11 66.6 COG3405@1|root,COG5295@1|root,COG3405@2|Bacteria,COG5295@2|Bacteria,4NF6Q@976|Bacteroidetes,47KN7@768503|Cytophagia 976|Bacteroidetes GUW candidate b-glycosidase, glycoside hydrolase family 8 protein - - - - - - - - - - - - Beta_helix,Big_3_3,M60-like_N,NosD,Peptidase_M60 k59_596046_2 1121033.AUCF01000003_gene3385 3.7e-48 159.0 2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria,2JSXP@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF3576) - - - - - - - - - - - - DUF3576 k59_815401_1 455632.SGR_4541 0.000316 49.3 COG1215@1|root,COG1887@1|root,COG1215@2|Bacteria,COG1887@2|Bacteria,2GM0T@201174|Actinobacteria,419R9@629295|Streptomyces griseus group 201174|Actinobacteria M Glycosyltransferase like family 2 - - 2.7.8.12 ko:K09809 - - - - ko00000,ko01000 - - - Glycos_transf_2,Glyphos_transf k59_596048_1 946483.Cenrod_2578 3.42e-36 140.0 COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG3614@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG3614@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,4AJX3@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_65715_1 566466.NOR53_1289 4.14e-69 223.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1J4SQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M UDP binding domain wbpO - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1031119_1 1120977.JHUX01000003_gene1931 7.62e-49 157.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,3NNVH@468|Moraxellaceae 1236|Gammaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_743131_1 296591.Bpro_1667 4.02e-87 283.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1100504_1 1380394.JADL01000005_gene5378 8.88e-119 350.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,2JQFG@204441|Rhodospirillales 204441|Rhodospirillales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_566513_1 443143.GM18_0058 4.49e-26 110.0 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - DUF1566,EF-hand_5,FGE-sulfatase,Lactamase_B_2,PD40,Peptidase_S9 k59_29462_1 748247.AZKH_0566 1.3e-77 248.0 2DBNG@1|root,2ZA3W@2|Bacteria,1P5DN@1224|Proteobacteria,2VPD3@28216|Betaproteobacteria,2KVWK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_173395_1 1353529.M899_2089 5.18e-23 100.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,42V3F@68525|delta/epsilon subdivisions,2MTKU@213481|Bdellovibrionales,2WR8K@28221|Deltaproteobacteria 213481|Bdellovibrionales S PQQ-like domain yfgL - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_953007_1 649747.HMPREF0083_00279 4.1e-26 112.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins - - - ko:K16123,ko:K16124 ko01054,map01054 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_281578_2 204773.HEAR2912 3.76e-58 186.0 COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,473TQ@75682|Oxalobacteraceae 28216|Betaproteobacteria S signal sequence binding sco1 - - - - - - - - - - - - k59_29484_1 1336237.JAEE01000001_gene2135 4.65e-16 75.1 28J2E@1|root,2Z8YX@2|Bacteria,1REPW@1224|Proteobacteria,1S4IX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_953023_1 614083.AWQR01000018_gene1801 8.32e-42 152.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,4ABNC@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_596106_1 1095769.CAHF01000013_gene3224 6.61e-111 328.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,4723K@75682|Oxalobacteraceae 28216|Betaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_497789_1 1458275.AZ34_09265 5.68e-55 184.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,4AA77@80864|Comamonadaceae 28216|Betaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_497789_2 358220.C380_08430 3.72e-12 65.1 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,4AA31@80864|Comamonadaceae 28216|Betaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_173439_1 1054213.HMPREF9946_05096 2.92e-19 86.3 2E78G@1|root,331S4@2|Bacteria,1N78C@1224|Proteobacteria,2UG9X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3016) - - - - - - - - - - - - DUF3016 k59_719300_1 398578.Daci_1942 3.42e-69 222.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2VN61@28216|Betaproteobacteria,4AIY5@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_186626_1 1229205.BUPH_03798 4.87e-30 119.0 COG0582@1|root,COG0582@2|Bacteria,1QY45@1224|Proteobacteria,2WHB8@28216|Betaproteobacteria,1K75C@119060|Burkholderiaceae 28216|Betaproteobacteria L viral genome integration into host DNA - - - - - - - - - - - - Phage_integrase k59_255877_1 1198452.Jab_1c13700 2.64e-82 253.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,473DR@75682|Oxalobacteraceae 28216|Betaproteobacteria T LytTr DNA-binding domain algR - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1079367_1 1000565.METUNv1_01539 2.31e-88 275.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,2KV0H@206389|Rhodocyclales 206389|Rhodocyclales F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_329388_1 395494.Galf_2550 3.32e-60 208.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,2VQUC@28216|Betaproteobacteria,44WD9@713636|Nitrosomonadales 28216|Betaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 k59_861158_2 398578.Daci_1573 5.12e-63 194.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,4AE26@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_861158_3 596153.Alide_3631 1.75e-12 65.5 COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria,4ADYW@80864|Comamonadaceae 28216|Betaproteobacteria NT PFAM CheW domain protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_898622_1 1100721.ALKO01000003_gene2410 1.1e-17 81.3 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJAM@28216|Betaproteobacteria,4AANH@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_898622_2 614083.AWQR01000018_gene1740 4.14e-57 189.0 COG4177@1|root,COG4177@2|Bacteria,1MY3V@1224|Proteobacteria,2VJIE@28216|Betaproteobacteria,4A9KX@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_968296_1 1157708.KB907450_gene6434 9.16e-101 294.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,4ABNT@80864|Comamonadaceae 28216|Betaproteobacteria F Nudix hydrolase nudC_1 - - - - - - - - - - - NUDIX,Nudix_N_2 k59_1079387_1 29581.BW37_04760 1.32e-90 277.0 COG2942@1|root,COG2942@2|Bacteria,1MX1J@1224|Proteobacteria,2VKG0@28216|Betaproteobacteria,473S8@75682|Oxalobacteraceae 28216|Betaproteobacteria G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) - - - - - - - - - - - - GlcNAc_2-epim k59_508038_1 614083.AWQR01000021_gene230 1.23e-14 71.6 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,4AADM@80864|Comamonadaceae 28216|Betaproteobacteria J S-adenosylmethionine-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_508038_2 1123255.JHYS01000001_gene1932 7.06e-70 220.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,4ABM6@80864|Comamonadaceae 28216|Betaproteobacteria S Cobalamin synthesis protein P47K yjiA_1 - - - - - - - - - - - CobW_C,cobW k59_399136_2 864051.BurJ1DRAFT_0982 9.2e-30 110.0 COG1544@1|root,COG1544@2|Bacteria,1RHW2@1224|Proteobacteria,2VTHD@28216|Betaproteobacteria,1KM86@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - - - - - - - - - - - k59_112032_1 1353529.M899_2200 6.81e-91 280.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2MSQ5@213481|Bdellovibrionales,2WJBC@28221|Deltaproteobacteria 213481|Bdellovibrionales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner - - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_topoisoIV k59_1079391_1 1000565.METUNv1_03633 1.3e-124 361.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,2KUA7@206389|Rhodocyclales 206389|Rhodocyclales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_1079391_2 1000565.METUNv1_03634 7.37e-29 110.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWIW@206389|Rhodocyclales 206389|Rhodocyclales T Forkhead associated domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_469750_3 1538295.JY96_14885 1.36e-116 341.0 COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,2WGBZ@28216|Betaproteobacteria,1KK0Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1005104_1 1000565.METUNv1_02598 3.95e-91 269.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,2KW7A@206389|Rhodocyclales 206389|Rhodocyclales F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_1005104_2 1000565.METUNv1_02597 3.5e-259 733.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,2KUJ4@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1110996_1 1300345.LF41_805 9.33e-39 149.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RZ1Q@1236|Gammaproteobacteria,1X5KK@135614|Xanthomonadales 135614|Xanthomonadales P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_508052_1 862908.BMS_0229 2.42e-78 241.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2MSWZ@213481|Bdellovibrionales,2WJH5@28221|Deltaproteobacteria 213481|Bdellovibrionales J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_898640_1 1000565.METUNv1_02657 3.7e-64 200.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,2KUET@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_898640_2 1000565.METUNv1_02658 1.6e-33 124.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,2KUDP@206389|Rhodocyclales 206389|Rhodocyclales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_575538_2 1286631.X805_09410 1.18e-71 219.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2VQ71@28216|Betaproteobacteria,1KN9C@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_575539_1 1480694.DC28_01970 6.81e-80 259.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity rtpR - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC k59_610525_1 1000565.METUNv1_02721 7.24e-256 708.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,2KV5W@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_77078_1 1000565.METUNv1_01010 4.99e-120 357.0 2DBNG@1|root,2ZA3W@2|Bacteria,1P5DN@1224|Proteobacteria,2VPD3@28216|Betaproteobacteria,2KVWK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1079418_1 929713.NIASO_19245 2.35e-47 155.0 COG0720@1|root,COG0720@2|Bacteria,4NNY0@976|Bacteroidetes,1ISCG@117747|Sphingobacteriia 976|Bacteroidetes H 6-pyruvoyl tetrahydrobiopterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1111002_1 398578.Daci_0475 4.09e-155 453.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,2VQKM@28216|Betaproteobacteria,4AEPD@80864|Comamonadaceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_292057_1 614083.AWQR01000006_gene303 3.3e-72 231.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MUAK@1224|Proteobacteria,2VIS3@28216|Betaproteobacteria,4ACJ3@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_508079_1 640081.Dsui_1877 2.24e-100 301.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,2KU6B@206389|Rhodocyclales 206389|Rhodocyclales C NADH flavin oxidoreductase NADH oxidase - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_1079423_3 1000565.METUNv1_02449 9.86e-131 376.0 COG0861@1|root,COG0861@2|Bacteria,1MXSK@1224|Proteobacteria,2VHZ5@28216|Betaproteobacteria,2KW4M@206389|Rhodocyclales 206389|Rhodocyclales P Integral membrane protein TerC family - - - - - - - - - - - - TerC k59_41775_1 1122236.KB905141_gene1487 1.02e-11 61.2 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,2KMSF@206350|Nitrosomonadales 206350|Nitrosomonadales E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_651122_1 1000565.METUNv1_01905 3.51e-102 301.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales 206389|Rhodocyclales K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_469779_1 296591.Bpro_5384 1.71e-84 259.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K10914,ko:K21558 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_898669_1 1232683.ADIMK_2593 1.56e-106 333.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,469HX@72275|Alteromonadaceae 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_5295_1 1000565.METUNv1_00372 3.71e-77 234.0 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,2KX54@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_5295_2 1000565.METUNv1_00373 2.92e-165 465.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,2KUZX@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_682717_1 338969.Rfer_0298 4.27e-97 292.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2VPD5@28216|Betaproteobacteria,4AE9K@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_682717_2 1458427.BAWN01000009_gene631 2.48e-20 83.2 COG0633@1|root,COG0633@2|Bacteria,1PTDB@1224|Proteobacteria,2VTTT@28216|Betaproteobacteria,4AJK6@80864|Comamonadaceae 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_436792_1 1121116.KB894770_gene1134 5.48e-84 258.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VJ5B@28216|Betaproteobacteria,4AC0Y@80864|Comamonadaceae 28216|Betaproteobacteria S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_540825_1 1000565.METUNv1_00805 1.14e-86 271.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,2KUJ4@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4 k59_899590_1 1188252.AJYK01000020_gene1683 1.35e-20 96.7 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria,1Y2BN@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_1111604_1 1267211.KI669560_gene1937 3.9e-32 112.0 COG0333@1|root,COG0333@2|Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_969003_1 1198452.Jab_2c24940 6.14e-68 221.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,4737S@75682|Oxalobacteraceae 28216|Betaproteobacteria M Mechanosensitive ion channel aefA - - - - - - - - - - - MS_channel k59_1006381_1 614083.AWQR01000009_gene596 5.1e-73 225.0 COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,2VM0A@28216|Betaproteobacteria,4A9UQ@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM metallophosphoesterase - - - - - - - - - - - - Metallophos_2 k59_1006381_2 614083.AWQR01000009_gene597 1.1e-60 200.0 COG0515@1|root,COG0589@1|root,COG0515@2|Bacteria,COG0589@2|Bacteria,1MV1P@1224|Proteobacteria,2VM52@28216|Betaproteobacteria,4ACA6@80864|Comamonadaceae 28216|Betaproteobacteria KLT Serine threonine protein kinase - - - - - - - - - - - - Pkinase,Usp k59_363930_1 1502852.FG94_01455 1.84e-122 368.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4734N@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_683365_1 1000565.METUNv1_02109 1.44e-104 323.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KUWE@206389|Rhodocyclales 206389|Rhodocyclales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1042048_1 864069.MicloDRAFT_00029530 2.13e-25 102.0 COG0583@1|root,COG0583@2|Bacteria,1QU1H@1224|Proteobacteria,2U0TE@28211|Alphaproteobacteria,1JU6R@119045|Methylobacteriaceae 28211|Alphaproteobacteria K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_652599_1 1348657.M622_03295 9.66e-59 182.0 COG4453@1|root,COG4453@2|Bacteria,1N05T@1224|Proteobacteria,2VVJP@28216|Betaproteobacteria,2KZ05@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_652599_2 1348657.M622_03290 2.52e-25 97.4 COG3153@1|root,COG3153@2|Bacteria,1QUSG@1224|Proteobacteria,2VKN1@28216|Betaproteobacteria,2KW27@206389|Rhodocyclales 206389|Rhodocyclales S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_899616_2 1005395.CSV86_24749 2.77e-06 50.1 2BVH3@1|root,32QVR@2|Bacteria,1RM2I@1224|Proteobacteria,1S6I0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized conserved protein (DUF2190) - - - - - - - - - - - - DUF2190 k59_6098_1 1000565.METUNv1_02683 2.3e-135 403.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales 206389|Rhodocyclales E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_6098_2 1000565.METUNv1_02682 2.65e-132 385.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2VJGZ@28216|Betaproteobacteria,2KVBT@206389|Rhodocyclales 206389|Rhodocyclales M lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_188168_1 1219375.CM002139_gene3459 6.2e-09 56.6 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1X3T2@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_188168_2 1429851.X548_07045 1.1e-37 137.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,1RPSG@1236|Gammaproteobacteria,1X4N9@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0324 family - - - - - - - - - - - - Cons_hypoth698 k59_330892_1 1121035.AUCH01000027_gene3387 6.73e-56 191.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - DUF4214,DUF5122,HemolysinCabind,Laminin_G_3,VCBS k59_683387_1 614083.AWQR01000006_gene288 9.08e-96 291.0 COG0412@1|root,COG0412@2|Bacteria,1PKGT@1224|Proteobacteria,2VINS@28216|Betaproteobacteria,4AEMA@80864|Comamonadaceae 28216|Betaproteobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH,Peptidase_S9 k59_148227_1 397945.Aave_2067 1.5e-32 124.0 COG3774@1|root,COG3774@2|Bacteria 2|Bacteria M pathogenesis - - - - - - - - - - - - Gly_transf_sug k59_1111643_1 1000565.METUNv1_02239 1.59e-95 288.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKJI@28216|Betaproteobacteria,2KVFT@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1111643_2 1000565.METUNv1_02238 5.84e-12 64.7 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,2KXUG@206389|Rhodocyclales 206389|Rhodocyclales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_576264_2 98439.AJLL01000036_gene2693 1.02e-10 61.6 COG1216@1|root,COG1216@2|Bacteria,1G3NM@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_438332_1 1293054.HSACCH_01331 2.84e-23 110.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - - k59_610938_1 1000565.METUNv1_03264 1.73e-161 457.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,2KU8M@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the ParB family spoOJ - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_933220_1 1538295.JY96_18775 3.04e-71 232.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VKXT@28216|Betaproteobacteria,1KJ5Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria KT Domain present in phytochromes and cGMP-specific phosphodiesterases. nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_330928_1 420662.Mpe_A1710 7.76e-184 524.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,1KKXI@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_330928_2 358220.C380_02330 4.92e-37 135.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,4ABDA@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Major facilitator superfamily narK1 - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_720116_1 1168034.FH5T_09780 1.01e-30 117.0 COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes,2FWWQ@200643|Bacteroidia 976|Bacteroidetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11 k59_720116_2 269799.Gmet_1812 5.51e-05 47.8 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_1006450_1 583345.Mmol_1419 2.11e-16 80.1 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KKWS@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM EAL domain - - - - - - - - - - - - EAL,GGDEF,PAS_3 k59_1006450_2 614083.AWQR01000038_gene1427 2.53e-68 228.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,4A9YM@80864|Comamonadaceae 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_540883_1 1000565.METUNv1_01060 8.45e-103 317.0 COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,2VK59@28216|Betaproteobacteria,2KV8J@206389|Rhodocyclales 206389|Rhodocyclales T 5TM C-terminal transporter carbon starvation CstA - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_862049_1 1286631.X805_29730 1.21e-66 209.0 28HPC@1|root,2Z7XD@2|Bacteria,1REIX@1224|Proteobacteria,2VS60@28216|Betaproteobacteria,1KMBS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Domain of unknown function (DUF4337) - - - - - - - - - - - - DUF4337 k59_78296_1 123214.PERMA_1436 0.000132 50.8 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg_2,Haemagg_act k59_1022552_1 1294143.H681_06330 7.32e-102 304.0 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,1RYA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria I fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_212563_1 358220.C380_08160 1.02e-83 268.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,4AD71@80864|Comamonadaceae 28216|Betaproteobacteria P receptor - - - ko:K16090 - - - - ko00000,ko02000 1.B.14.1.11 - - Plug,TonB_dep_Rec k59_735140_2 1000565.METUNv1_00933 1.66e-72 225.0 COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VQUA@28216|Betaproteobacteria,2KXH3@206389|Rhodocyclales 206389|Rhodocyclales KT HD domain - - - - - - - - - - - - HD_4 k59_488258_1 1000565.METUNv1_01313 5.08e-75 250.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales 206389|Rhodocyclales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_312132_1 232721.Ajs_1979 2.12e-79 258.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,4AAP4@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_984141_1 1304872.JAGC01000009_gene721 1.84e-46 170.0 COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43C3H@68525|delta/epsilon subdivisions,2X8FM@28221|Deltaproteobacteria,2MHHR@213115|Desulfovibrionales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_413557_1 1122604.JONR01000001_gene1701 2.2e-12 67.8 COG4221@1|root,COG4221@2|Bacteria,1RI15@1224|Proteobacteria,1S6V3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_413557_2 716541.ECL_01748 1.23e-27 107.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,3X25S@547|Enterobacter 1236|Gammaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 OMPdecase k59_589487_1 987059.RBXJA2T_14686 2.21e-107 323.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,1KJNP@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_914096_1 1000565.METUNv1_03283 1.91e-100 308.0 COG0664@1|root,COG2172@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,2KX5A@206389|Rhodocyclales 206389|Rhodocyclales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_1022578_2 929713.NIASO_06850 4.73e-31 121.0 COG1748@1|root,COG1748@2|Bacteria,4NFM8@976|Bacteroidetes,1IQ3W@117747|Sphingobacteriia 976|Bacteroidetes E Saccharopine dehydrogenase - - 1.5.1.10,1.5.1.7 ko:K00290,ko:K00293 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R02315 RC00215,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_58462_1 338969.Rfer_0899 4.05e-65 200.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2VSKU@28216|Betaproteobacteria,4ADZ6@80864|Comamonadaceae 28216|Betaproteobacteria T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_165180_1 204773.HEAR3018 2.89e-105 326.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,472U8@75682|Oxalobacteraceae 28216|Betaproteobacteria K Likely ribonuclease with RNase H fold. tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_165180_2 864073.HFRIS_011628 5.98e-52 177.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,4724I@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde dehydrogenase family acoD - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_231962_1 1458275.AZ34_15370 2.73e-24 102.0 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,2VJK9@28216|Betaproteobacteria,4A9PN@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM ResB family protein resB - - ko:K07399 - - - - ko00000 - - - ResB k59_231962_2 1123399.AQVE01000010_gene3291 2.11e-06 51.2 COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,1RX07@1236|Gammaproteobacteria,45ZPJ@72273|Thiotrichales 72273|Thiotrichales O PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_22163_1 497321.C664_02025 5.83e-77 250.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,2KVIF@206389|Rhodocyclales 206389|Rhodocyclales NU COG1450 Type II secretory pathway, component PulD - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_212628_1 1122951.ATUE01000006_gene1207 1.12e-104 317.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,3NK8K@468|Moraxellaceae 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_844733_1 1454004.AW11_00612 1.98e-75 238.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VKX2@28216|Betaproteobacteria 28216|Betaproteobacteria M FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_231963_1 925409.KI911562_gene2255 2.6e-24 102.0 2B47E@1|root,31WYM@2|Bacteria,4P1U8@976|Bacteroidetes,1IVZ7@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_231963_2 926550.CLDAP_04410 2.43e-27 112.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,2G68T@200795|Chloroflexi 200795|Chloroflexi T histidine kinase HAMP region domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1022617_1 911045.PSE_1169 5.06e-24 107.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria D protein involved in exopolysaccharide biosynthesis exoP - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,Wzz k59_165200_1 1122951.ATUE01000008_gene178 1.05e-64 209.0 COG2207@1|root,COG2207@2|Bacteria,1NVER@1224|Proteobacteria,1RQWM@1236|Gammaproteobacteria,3NJRU@468|Moraxellaceae 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_879312_1 1353529.M899_1365 3.37e-57 189.0 COG3093@1|root,COG3093@2|Bacteria,1P59P@1224|Proteobacteria,43343@68525|delta/epsilon subdivisions,2MUG7@213481|Bdellovibrionales,2WXZZ@28221|Deltaproteobacteria 213481|Bdellovibrionales K Domain of unknown function (DUF4423) - - - - - - - - - - - - DUF4423 k59_879313_1 1502852.FG94_04406 8.98e-37 132.0 COG1161@1|root,COG1161@2|Bacteria,1MV5H@1224|Proteobacteria,2VHAG@28216|Betaproteobacteria,472E6@75682|Oxalobacteraceae 28216|Betaproteobacteria S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity ylqF - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_22187_1 1150469.RSPPHO_01651 1.45e-62 219.0 COG0642@1|root,COG3829@1|root,COG5002@1|root,COG0642@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TZDS@28211|Alphaproteobacteria,2JZ03@204441|Rhodospirillales 204441|Rhodospirillales T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_844769_1 1121033.AUCF01000013_gene1599 1.02e-120 363.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_413610_1 748247.AZKH_1290 2.87e-94 297.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,2KUGX@206389|Rhodocyclales 206389|Rhodocyclales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_58520_1 1196083.SALWKB12_1120 7.73e-39 140.0 COG1396@1|root,32D3J@2|Bacteria,1RIFQ@1224|Proteobacteria,2VXPN@28216|Betaproteobacteria,2KS50@206351|Neisseriales 206351|Neisseriales K sequence-specific DNA binding - - - - - - - - - - - - ORF6C k59_488363_1 85643.Tmz1t_3592 4.79e-29 115.0 COG1765@1|root,COG1944@1|root,COG1765@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,2VHZY@28216|Betaproteobacteria,2KV2Z@206389|Rhodocyclales 206389|Rhodocyclales O redox protein, regulator of disulfide bond formation - - - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO k59_879343_1 1005048.CFU_3703 1.21e-50 177.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,472DT@75682|Oxalobacteraceae 28216|Betaproteobacteria M D-Ala-D-Ala carboxypeptidase 3 (S13) family dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1126281_1 1100721.ALKO01000003_gene2043 2.96e-88 261.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,4ADGK@80864|Comamonadaceae 28216|Betaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_488365_1 1122951.ATUE01000006_gene1169 3.81e-05 44.7 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,3NKYC@468|Moraxellaceae 1236|Gammaproteobacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_383031_1 1500894.JQNN01000001_gene3149 1.81e-48 169.0 COG3240@1|root,COG3240@2|Bacteria,1N4ZT@1224|Proteobacteria,2VGZ4@28216|Betaproteobacteria 28216|Betaproteobacteria I lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL k59_165247_1 365044.Pnap_2906 4.94e-16 77.8 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,4ABW3@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_383040_1 640081.Dsui_2890 1.96e-87 276.0 COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,2KUU5@206389|Rhodocyclales 206389|Rhodocyclales T EAL domain - - - - - - - - - - - - EAL,GGDEF k59_165250_1 330214.NIDE3403 1.3e-06 50.1 COG2095@1|root,COG2095@2|Bacteria,3J0UZ@40117|Nitrospirae 40117|Nitrospirae U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1126294_2 1123073.KB899242_gene1548 2.01e-09 63.5 COG0515@1|root,COG0515@2|Bacteria,1PHES@1224|Proteobacteria,1RX60@1236|Gammaproteobacteria,1X9TY@135614|Xanthomonadales 135614|Xanthomonadales KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_413645_1 925409.KI911562_gene2245 1.24e-39 136.0 COG0163@1|root,COG0163@2|Bacteria,4NIBD@976|Bacteroidetes,1INXX@117747|Sphingobacteriia 976|Bacteroidetes H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_413645_2 925409.KI911562_gene2246 2.76e-29 114.0 COG0058@1|root,COG0058@2|Bacteria,4NGR1@976|Bacteroidetes,1IPKK@117747|Sphingobacteriia 976|Bacteroidetes G COGs COG0058 Glucan phosphorylase glgP - 2.4.1.1,2.4.1.8 ko:K00688,ko:K00691 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R01555,R02111 RC00049 ko00000,ko00001,ko01000 - GH65,GT35 - DUF3417,Phosphorylase k59_623026_1 748280.NH8B_1148 0.00053 42.4 2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_946700_1 1276756.AUEX01000003_gene705 2.79e-49 178.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE3,PAS,PAS_4,PAS_9 k59_165261_1 1177181.T9A_03157 1.21e-107 324.0 COG1773@1|root,COG3239@1|root,COG1773@2|Bacteria,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alkane 1-monooxygenase - - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase,Rubredoxin k59_558385_1 105559.Nwat_2424 3.13e-77 242.0 COG0732@1|root,COG0732@2|Bacteria,1R4KU@1224|Proteobacteria,1SAJW@1236|Gammaproteobacteria,1WZAA@135613|Chromatiales 135613|Chromatiales L PFAM restriction modification system DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_844831_1 204773.HEAR1853 1.12e-15 78.2 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,476AX@75682|Oxalobacteraceae 28216|Betaproteobacteria U TIGRFAM filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - ESPR,Glug,Haemagg_act k59_844831_2 1122185.N792_10705 5.31e-20 90.5 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,1RYVX@1236|Gammaproteobacteria,1X6KU@135614|Xanthomonadales 135614|Xanthomonadales U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_488403_1 1000565.METUNv1_02363 4.36e-100 318.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJX9@28216|Betaproteobacteria 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_3 k59_986166_2 1000565.METUNv1_01885 4.39e-111 323.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,2KUMW@206389|Rhodocyclales 206389|Rhodocyclales E Hydrolase - - - - - - - - - - - - HAD k59_314590_1 596154.Alide2_4008 3.14e-37 132.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,4ABH1@80864|Comamonadaceae 28216|Betaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_314590_2 596154.Alide2_4007 4.93e-60 194.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VHCB@28216|Betaproteobacteria,4AA8K@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein qor1 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_385673_1 595460.RRSWK_05050 6.48e-111 337.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_60259_1 189753.AXAS01000009_gene6475 7.87e-75 239.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2U0KW@28211|Alphaproteobacteria,3JXHR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_560639_1 572477.Alvin_2661 2.24e-67 221.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WVY9@135613|Chromatiales 135613|Chromatiales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_415301_1 266264.Rmet_0192 1.21e-60 211.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,1KBUP@119060|Burkholderiaceae 28216|Betaproteobacteria NU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1128232_1 614083.AWQR01000026_gene3560 4.27e-113 355.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - EAL,GAF,GGDEF,HAMP,PAS,PAS_4,PAS_9,PilJ,Response_reg k59_986187_1 522306.CAP2UW1_1530 2.65e-65 208.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,1KPUB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_490555_1 658612.MD26_04795 1.35e-82 253.0 COG1715@1|root,COG1715@2|Bacteria,1R3ZM@1224|Proteobacteria 1224|Proteobacteria V Restriction endonuclease - - - - - - - - - - - - DUF3644,Mrr_cat k59_233564_1 568706.BN118_3727 6.25e-109 326.0 COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,3T1V5@506|Alcaligenaceae 28216|Betaproteobacteria P Belongs to the catalase family katA - 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase,Catalase-rel k59_1065897_1 269482.Bcep1808_3465 8.36e-16 77.0 COG0583@1|root,COG0583@2|Bacteria,1NWDY@1224|Proteobacteria,2WEC5@28216|Betaproteobacteria,1KFVI@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_23975_1 1288826.MSNKSG1_17441 6.56e-18 85.1 COG2067@1|root,COG2067@2|Bacteria,1RA6W@1224|Proteobacteria,1RPD8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG2067 Long-chain fatty acid transport protein - - - - - - - - - - - - Toluene_X k59_915832_1 1336803.PHEL49_1461 1.88e-42 156.0 COG0243@1|root,COG0243@2|Bacteria,4PIKC@976|Bacteroidetes,1ICDV@117743|Flavobacteriia,3VXCJ@52959|Polaribacter 976|Bacteroidetes C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_60291_1 1000565.METUNv1_00150 1.89e-73 248.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VPUH@28216|Betaproteobacteria,2KW4J@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_624505_1 279714.FuraDRAFT_2193 8.44e-72 218.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2VI3V@28216|Betaproteobacteria,2KRM0@206351|Neisseriales 206351|Neisseriales T Low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_624505_2 595494.Tola_2507 3.16e-36 125.0 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,1S5VQ@1236|Gammaproteobacteria,1Y5WR@135624|Aeromonadales 135624|Aeromonadales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_60308_1 398578.Daci_1232 8.84e-30 121.0 COG3000@1|root,COG3714@1|root,COG3000@2|Bacteria,COG3714@2|Bacteria,1NR7X@1224|Proteobacteria,2VJ4E@28216|Betaproteobacteria,4ABMB@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase,YhhN k59_881341_1 700598.Niako_6962 2.01e-35 130.0 COG1078@1|root,COG1078@2|Bacteria,4NE1T@976|Bacteroidetes,1IQIS@117747|Sphingobacteriia 976|Bacteroidetes S phosphohydrolase - - - ko:K06885 - - - - ko00000 - - - HD k59_881341_2 1123248.KB893348_gene296 1.23e-22 95.9 COG2204@1|root,COG2204@2|Bacteria,4NE72@976|Bacteroidetes,1IP34@117747|Sphingobacteriia 976|Bacteroidetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains porX - - - - - - - - - - - PglZ,Response_reg k59_1065953_1 1287276.X752_04710 1.22e-31 124.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43HD6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T DNA-binding transcriptional activator of the SARP family - - - - - - - - - - - - BTAD,Trans_reg_C k59_560728_1 29581.BW37_04765 1.43e-62 206.0 COG4580@1|root,COG4580@2|Bacteria,1MX77@1224|Proteobacteria,2VKXK@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM porin LamB type lamB - - ko:K02024 - - - - ko00000,ko02000 1.B.3.1.1 - - LamB k59_1024829_1 983917.RGE_37370 2.36e-30 111.0 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,2VW7C@28216|Betaproteobacteria,1KNY3@119065|unclassified Burkholderiales 28216|Betaproteobacteria P ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_1024829_2 243231.GSU0683 2.46e-05 46.2 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales 28221|Deltaproteobacteria NT histidine kinase HAMP region domain protein mcp34H-6 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CHASE3,CZB,HAMP,MCPsignal,dCache_1 k59_490615_1 1163617.SCD_n02983 4.69e-46 166.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2VHMP@28216|Betaproteobacteria 28216|Betaproteobacteria GM abc transporter rfbE - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_490615_2 326423.RBAM_035500 9.71e-26 104.0 COG2227@1|root,COG2227@2|Bacteria,1W0ME@1239|Firmicutes,4HQ1K@91061|Bacilli,1ZEK5@1386|Bacillus 91061|Bacilli H Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_23 k59_275926_1 522306.CAP2UW1_3240 2.16e-08 60.8 COG1404@1|root,COG2931@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - HCBP_related,HemolysinCabind,PPC,Peptidase_M10_C,Reprolysin_4 k59_948367_1 1242864.D187_003204 4.65e-110 327.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,43EAF@68525|delta/epsilon subdivisions,2X34W@28221|Deltaproteobacteria,2YUA3@29|Myxococcales 28221|Deltaproteobacteria S N-terminal domain of oxidoreductase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_415377_1 1005048.CFU_3177 3.94e-62 208.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,47408@75682|Oxalobacteraceae 28216|Betaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 k59_1024854_1 614083.AWQR01000052_gene3412 2.34e-52 173.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,4AAN0@80864|Comamonadaceae 28216|Betaproteobacteria S Displays ATPase and GTPase activities yhbJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_1024854_2 1100720.ALKN01000024_gene1530 3.06e-15 75.5 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,4AA94@80864|Comamonadaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_505755_1 1000565.METUNv1_02025 1.93e-75 234.0 COG3221@1|root,COG3221@2|Bacteria,1N5FI@1224|Proteobacteria,2VTXP@28216|Betaproteobacteria,2KWYV@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - - - - - - - - - - Phosphonate-bd k59_648667_1 1000565.METUNv1_04045 1.86e-74 253.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_681600_1 595537.Varpa_5163 5.02e-45 160.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,4AD4H@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM type I secretion membrane fusion protein, HlyD family - - - ko:K12542,ko:K16300 - M00330,M00571 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1,8.A.1.3.3 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_753085_1 596154.Alide2_4070 1.89e-62 195.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2VIFV@28216|Betaproteobacteria,4ABQ9@80864|Comamonadaceae 28216|Betaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_40383_1 1218074.BAXZ01000011_gene2699 1.07e-37 137.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2VHX0@28216|Betaproteobacteria,1K0SX@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_40383_2 760117.JN27_09925 4.06e-12 63.2 COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,478S9@75682|Oxalobacteraceae 28216|Betaproteobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_825058_1 1293054.HSACCH_01331 1.39e-22 108.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - - k59_468352_1 1000565.METUNv1_03838 1.13e-34 129.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales 28216|Betaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_468352_2 1000565.METUNv1_03839 8.13e-30 116.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,2KVGH@206389|Rhodocyclales 206389|Rhodocyclales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_825062_1 1000565.METUNv1_02702 5.82e-42 153.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVA4@206389|Rhodocyclales 206389|Rhodocyclales U efflux pump - - - ko:K18138,ko:K18146 ko01501,ko01503,map01501,map01503 M00647,M00649,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.40 - - ACR_tran k59_825062_2 1000565.METUNv1_02701 8.9e-37 134.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KVSS@206389|Rhodocyclales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23,OmpA k59_789886_2 522306.CAP2UW1_0862 1.1e-11 69.3 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - Beta_helix,DUF642 k59_789886_3 93220.LV28_08420 9.77e-52 173.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VIWA@28216|Betaproteobacteria,1JZW2@119060|Burkholderiaceae 28216|Betaproteobacteria M mechanosensitive ion channel mscS - - ko:K03442,ko:K16052 - - - - ko00000,ko02000 1.A.23.2,1.A.23.4 - - MS_channel,TM_helix k59_468358_1 1000565.METUNv1_01948 5.24e-155 446.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,2KUS9@206389|Rhodocyclales 206389|Rhodocyclales C glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1077056_1 1000565.METUNv1_01434 4.92e-121 379.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,2KUWB@206389|Rhodocyclales 206389|Rhodocyclales C FAD linked oxidase - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1039775_1 1000565.METUNv1_03842 8.26e-165 486.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales 206389|Rhodocyclales H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_361577_2 887062.HGR_09099 1.26e-65 200.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,4AEBZ@80864|Comamonadaceae 28216|Betaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_538995_1 1000565.METUNv1_02420 5.35e-109 322.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,2KW45@206389|Rhodocyclales 206389|Rhodocyclales M VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_789903_1 1000565.METUNv1_02835 1.03e-135 387.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,2KV6S@206389|Rhodocyclales 206389|Rhodocyclales O PFAM 20S proteasome, A and B subunits - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_290418_1 1396418.BATQ01000133_gene4005 2.46e-23 101.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - DUF1501 k59_290418_2 880070.Cycma_1442 8.71e-26 110.0 COG2010@1|root,COG2010@2|Bacteria,4NKWY@976|Bacteroidetes,47UE1@768503|Cytophagia 976|Bacteroidetes C Carbohydrate binding module (family 6) - - - - - - - - - - - - CBM_6,PSCyt1,PSCyt2,PSD1 k59_574454_1 338969.Rfer_1544 1.21e-112 337.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,4AAJR@80864|Comamonadaceae 28216|Betaproteobacteria S Polyphosphate kinase 2 (PPK2) pap - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_825105_2 1123367.C666_08940 5.53e-63 199.0 COG3440@1|root,COG3440@2|Bacteria,1NE0N@1224|Proteobacteria 1224|Proteobacteria V restriction endonuclease - - - ko:K07454 - - - - ko00000 - - - HNH_2 k59_505853_1 1000565.METUNv1_01101 1.42e-06 48.9 COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2VI2J@28216|Betaproteobacteria,2KUTT@206389|Rhodocyclales 206389|Rhodocyclales C Catalyzes the desulfonation of aliphatic sulfonates - - - - - - - - - - - - Bac_luciferase k59_505853_2 1000565.METUNv1_01100 1.82e-26 105.0 COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2VJ5J@28216|Betaproteobacteria,2KY45@206389|Rhodocyclales 206389|Rhodocyclales P NMT1-like family - - - - - - - - - - - - NMT1 k59_505866_1 1000565.METUNv1_01120 2.18e-154 460.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,2KVN8@206389|Rhodocyclales 206389|Rhodocyclales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1110054_1 358220.C380_10300 4.34e-87 269.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2WEXA@28216|Betaproteobacteria,4ACBT@80864|Comamonadaceae 28216|Betaproteobacteria P Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_290440_1 1000565.METUNv1_02450 2.03e-170 482.0 COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2WFNY@28216|Betaproteobacteria,2KVWM@206389|Rhodocyclales 206389|Rhodocyclales E Ornithine cyclodeaminase/mu-crystallin family - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_290440_2 1000565.METUNv1_02451 7.19e-96 304.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_40454_1 1000565.METUNv1_03892 6.62e-79 244.0 COG2304@1|root,COG2304@2|Bacteria,1QRQ4@1224|Proteobacteria,2W9WT@28216|Betaproteobacteria,2KZGA@206389|Rhodocyclales 2|Bacteria S von Willebrand factor type A domain - - - ko:K07114,ko:K16257 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_40454_2 1000565.METUNv1_03893 1.53e-37 136.0 297JP@1|root,2ZUSS@2|Bacteria,1RBY8@1224|Proteobacteria,2VQUJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - ko:K16256 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - - k59_397594_1 1000565.METUNv1_03545 2.29e-126 369.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,2KUR8@206389|Rhodocyclales 206389|Rhodocyclales T signal transduction protein containing EAL and modified HD-GYP domains - - - - - - - - - - - - HDOD k59_609624_2 1000565.METUNv1_02126 3.83e-67 209.0 COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,2VH72@28216|Betaproteobacteria,2KVXH@206389|Rhodocyclales 206389|Rhodocyclales C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_718295_1 1000565.METUNv1_02257 1.82e-203 602.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KUZA@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_110894_2 1000565.METUNv1_00853 6.61e-116 340.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,2VJTZ@28216|Betaproteobacteria,2KW57@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1110059_1 296591.Bpro_3622 4.66e-77 233.0 COG1451@1|root,COG1451@2|Bacteria,1RDJ9@1224|Proteobacteria,2VR4I@28216|Betaproteobacteria,4AE0J@80864|Comamonadaceae 28216|Betaproteobacteria S WLM domain ygjP - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1110059_2 296591.Bpro_3630 0.000193 42.7 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,4ABMP@80864|Comamonadaceae 28216|Betaproteobacteria G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_574474_1 1000565.METUNv1_00095 2.27e-12 75.1 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_184476_1 614083.AWQR01000053_gene3356 2.94e-109 324.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,4ABNA@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_110896_1 358220.C380_04755 8.2e-118 354.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,4AB70@80864|Comamonadaceae 28216|Betaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_146419_1 204773.HEAR1530 2.92e-134 388.0 COG4128@1|root,COG4128@2|Bacteria,1REHG@1224|Proteobacteria,2VRK2@28216|Betaproteobacteria 28216|Betaproteobacteria S Zonular occludens toxin (Zot) - - - - - - - - - - - - Zot k59_1003504_1 1000565.METUNv1_02034 1.38e-83 251.0 COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,2VSQI@28216|Betaproteobacteria,2KWMR@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU k59_1003504_3 1000565.METUNv1_02036 2.61e-56 176.0 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VVSV@28216|Betaproteobacteria,2KX9P@206389|Rhodocyclales 206389|Rhodocyclales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_290459_1 1217718.ALOU01000027_gene3625 2.25e-87 268.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1K0WZ@119060|Burkholderiaceae 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 ko:K00646,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Ketoacyl-synt_C,ketoacyl-synt k59_897118_1 452637.Oter_1616 6.15e-95 296.0 COG0642@1|root,COG2205@2|Bacteria,46TFN@74201|Verrucomicrobia 74201|Verrucomicrobia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_327365_1 1000565.METUNv1_01500 1.71e-89 267.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KUIS@206389|Rhodocyclales 206389|Rhodocyclales P Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_327365_2 1000565.METUNv1_01501 3.41e-92 280.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KUBF@206389|Rhodocyclales 206389|Rhodocyclales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_931299_1 1502852.FG94_04531 2.44e-50 180.0 COG2931@1|root,COG2931@2|Bacteria,1PGUW@1224|Proteobacteria,2VY3D@28216|Betaproteobacteria,477AP@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Domain of unknown function (DUF4214) - - - - - - - - - - - - DUF4214 k59_825148_1 292415.Tbd_0239 7.72e-60 195.0 2C5U9@1|root,30FF7@2|Bacteria,1N2U0@1224|Proteobacteria,2WIIE@28216|Betaproteobacteria,1KRXD@119069|Hydrogenophilales 119069|Hydrogenophilales S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_825148_3 1000565.METUNv1_03320 9.58e-71 229.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,2KVBV@206389|Rhodocyclales 206389|Rhodocyclales P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_468440_1 1279017.AQYJ01000029_gene3669 2.3e-21 90.1 COG2890@1|root,COG2890@2|Bacteria,1QW4Z@1224|Proteobacteria,1T3DV@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Methyl-transferase - - - - - - - - - - - - Methyltransf_12 k59_3999_1 1349767.GJA_1622 7.34e-114 342.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4738E@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family mucD - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_75315_1 471854.Dfer_4173 3.66e-35 135.0 COG4232@1|root,COG4232@2|Bacteria,4NEW6@976|Bacteroidetes,47JTC@768503|Cytophagia 976|Bacteroidetes CO Cytochrome c biogenesis protein transmembrane region dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_40490_1 1000565.METUNv1_00661 3.8e-107 313.0 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2VQBC@28216|Betaproteobacteria,2KW2V@206389|Rhodocyclales 206389|Rhodocyclales G Class II aldolase adducin family protein fucA - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II k59_825155_1 1123274.KB899439_gene3589 2.77e-65 210.0 COG0399@1|root,COG0399@2|Bacteria,2J6F4@203691|Spirochaetes 203691|Spirochaetes E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.33,2.6.1.98 ko:K13017,ko:K20429 ko00520,map00520 - R02773,R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_825155_2 1550091.JROE01000009_gene256 1.28e-09 55.5 COG1898@1|root,COG1898@2|Bacteria,4PKN3@976|Bacteroidetes,1ITPG@117747|Sphingobacteriia 976|Bacteroidetes M WxcM-like, C-terminal - - - - - - - - - - - - FdtA k59_539056_1 95619.PM1_0224470 1.94e-103 321.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,1RRTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase M50 - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3 k59_1041062_1 1192034.CAP_5021 2.31e-31 119.0 COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,2YV5J@29|Myxococcales 28221|Deltaproteobacteria Q ABC transporter permease - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1041062_2 999141.GME_15475 5.07e-19 86.3 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RQVA@1236|Gammaproteobacteria,1XKBM@135619|Oceanospirillales 135619|Oceanospirillales Q ABC transporter ATP-binding protein - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1079140_1 1157708.KB907451_gene4541 8.21e-82 262.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2VJ5N@28216|Betaproteobacteria,4AD5B@80864|Comamonadaceae 28216|Betaproteobacteria Q Alkyl sulfatase C-terminal - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,GMC_oxred_C,GMC_oxred_N,Lactamase_B k59_540042_1 1000565.METUNv1_02023 7.1e-29 114.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,2KURC@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1110899_1 1000565.METUNv1_01096 2.49e-114 337.0 COG1960@1|root,COG1960@2|Bacteria,1MYT7@1224|Proteobacteria,2VIFP@28216|Betaproteobacteria,2KXXG@206389|Rhodocyclales 206389|Rhodocyclales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_753991_1 243365.CV_1743 1.03e-41 152.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VK5J@28216|Betaproteobacteria,2KPD7@206351|Neisseriales 206351|Neisseriales F 5'-nucleotidase, C-terminal domain ushA - 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_753991_2 614083.AWQR01000039_gene1491 2.34e-27 111.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,4AD1X@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - DUF3365,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg,dCache_1 k59_540043_1 1000565.METUNv1_02520 3.64e-217 625.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KVNP@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_41604_1 1100720.ALKN01000045_gene316 2.9e-27 101.0 COG3093@1|root,COG3093@2|Bacteria,1N2BD@1224|Proteobacteria,2VVV1@28216|Betaproteobacteria,4AG2K@80864|Comamonadaceae 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_255748_1 504472.Slin_3852 9.85e-52 174.0 COG1216@1|root,COG1216@2|Bacteria,4NEJB@976|Bacteroidetes,47MPS@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_1079156_1 1000565.METUNv1_01491 3.82e-56 183.0 2C3MR@1|root,32RCH@2|Bacteria,1QZ0P@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_682573_2 1380394.JADL01000001_gene2570 5.85e-93 291.0 COG4783@1|root,COG4783@2|Bacteria,1NP1J@1224|Proteobacteria,2UK80@28211|Alphaproteobacteria,2JXWA@204441|Rhodospirillales 204441|Rhodospirillales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_682573_3 1121920.AUAU01000005_gene1079 1.59e-60 197.0 2EDW0@1|root,32VXH@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_682573_4 1000565.METUNv1_00605 2.12e-122 355.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,2KU6Q@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_41617_1 596154.Alide2_0635 3.04e-104 317.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,4AB4R@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_898475_1 1000565.METUNv1_02451 4.26e-183 533.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_791092_1 1000565.METUNv1_00780 1.08e-78 245.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,2KV70@206389|Rhodocyclales 206389|Rhodocyclales E Aminotransferase - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_791092_2 1000565.METUNv1_00779 7.58e-61 189.0 COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,2KWY2@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_791092_3 1000565.METUNv1_00778 1.63e-84 251.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,2KWEZ@206389|Rhodocyclales 206389|Rhodocyclales O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_791092_4 1121035.AUCH01000002_gene1493 2e-10 60.8 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,2KUNN@206389|Rhodocyclales 206389|Rhodocyclales T ATPase related to phosphate starvation-inducible protein PhoH - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_610433_1 1223521.BBJX01000005_gene2063 1.08e-123 361.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,4ABKZ@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_459203_1 666685.R2APBS1_1628 2.87e-31 129.0 COG3598@1|root,COG3598@2|Bacteria 2|Bacteria L Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_25,DUF927,HTH_23,Prim-Pol,RepB_primase k59_459208_1 1297742.A176_03179 2.38e-61 195.0 COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,1RGXE@1224|Proteobacteria,42QQW@68525|delta/epsilon subdivisions,2WPBR@28221|Deltaproteobacteria,2YVJY@29|Myxococcales 28221|Deltaproteobacteria E Urease, gamma subunit ureA - 3.5.1.5 ko:K01430,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta,Urease_gamma k59_1058073_1 397945.Aave_4657 9.72e-101 318.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,4A9PB@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_378097_1 1123400.KB904749_gene762 3.35e-05 45.8 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,45ZSY@72273|Thiotrichales 72273|Thiotrichales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_943914_1 614083.AWQR01000047_gene3267 1.12e-72 236.0 COG4135@1|root,COG4135@2|Bacteria,1MV6R@1224|Proteobacteria,2VNQ7@28216|Betaproteobacteria,4ACFW@80864|Comamonadaceae 28216|Betaproteobacteria P transport system, permease component - - - ko:K05778 - M00192 - - ko00000,ko00002,ko02000 - - - - k59_90323_1 279714.FuraDRAFT_1932 4.62e-69 223.0 COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,2VIN0@28216|Betaproteobacteria,2KPC2@206351|Neisseriales 206351|Neisseriales Q benzoate membrane transport protein - - - ko:K05782 - - - - ko00000,ko02000 2.A.46.1 - - BenE k59_270571_1 397945.Aave_1424 1.5e-163 467.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,4AB64@80864|Comamonadaceae 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_229304_1 358220.C380_02875 4.08e-111 325.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VJXH@28216|Betaproteobacteria,4ABB0@80864|Comamonadaceae 28216|Betaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - ko:K02049,ko:K15578 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.17 - - ABC_tran k59_765706_1 1000565.METUNv1_02818 1.21e-64 211.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,2KVHB@206389|Rhodocyclales 206389|Rhodocyclales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_765706_2 1000565.METUNv1_02817 2.05e-85 255.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,2KUB9@206389|Rhodocyclales 206389|Rhodocyclales S Phospholipid-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_840969_2 1349767.GJA_2233 1.04e-26 103.0 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2W3UQ@28216|Betaproteobacteria,474ZZ@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_459248_1 863365.XHC_1204 2.17e-81 253.0 COG2856@1|root,COG2856@2|Bacteria,1PFUN@1224|Proteobacteria,1RR40@1236|Gammaproteobacteria,1X3AW@135614|Xanthomonadales 135614|Xanthomonadales E Pfam:DUF955 - - - - - - - - - - - - Peptidase_M78 k59_673943_1 521674.Plim_2642 6.85e-88 269.0 COG1082@1|root,COG1082@2|Bacteria,2IWZG@203682|Planctomycetes 203682|Planctomycetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_805914_1 983548.Krodi_2363 3.55e-36 140.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,4NEI1@976|Bacteroidetes,1HXJI@117743|Flavobacteriia,37E9G@326319|Dokdonia 976|Bacteroidetes P E1-E2 ATPase ccoI - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_554532_1 454957.IA64_09660 1.09e-10 69.7 COG1305@1|root,COG1305@2|Bacteria,1Q712@1224|Proteobacteria,1RZ8Q@1236|Gammaproteobacteria,1X4S2@135614|Xanthomonadales 135614|Xanthomonadales E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core k59_876018_1 987059.RBXJA2T_14561 1.11e-72 242.0 COG0427@1|root,COG0427@2|Bacteria,1PX5H@1224|Proteobacteria,2W10N@28216|Betaproteobacteria,1KN6G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C k59_620686_1 1034807.FBFL15_1252 5.69e-38 134.0 2BFRA@1|root,329K3@2|Bacteria,4NR20@976|Bacteroidetes,1I5JZ@117743|Flavobacteriia,2P0CA@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1018997_1 1000565.METUNv1_03341 8.63e-21 90.9 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,2KVFR@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1018997_2 1000565.METUNv1_03340 1.62e-216 623.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,2KVFE@206389|Rhodocyclales 206389|Rhodocyclales H COG4206 Outer membrane cobalamin receptor protein - - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec k59_55433_1 686578.AFFX01000001_gene1501 1.57e-19 86.3 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria 1236|Gammaproteobacteria S associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_55433_2 477228.YO5_15430 3.06e-23 97.4 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1Z0SD@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_732379_1 929556.Solca_2036 6.7e-48 155.0 COG0292@1|root,COG0292@2|Bacteria,4NNKU@976|Bacteroidetes,1ISA4@117747|Sphingobacteriia 976|Bacteroidetes J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_911276_1 1122951.ATUE01000007_gene795 2.64e-55 184.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,3NKDW@468|Moraxellaceae 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_911276_2 1122951.ATUE01000007_gene794 2.33e-13 68.9 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,3NJGX@468|Moraxellaceae 1236|Gammaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iPC815.YPO1056 Acetyltransf_11,Hexapep k59_765749_1 1353529.M899_3326 2.68e-146 430.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2MSTU@213481|Bdellovibrionales,2WIWS@28221|Deltaproteobacteria 213481|Bdellovibrionales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_162091_1 470.IX87_10295 2.46e-139 421.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,3NISD@468|Moraxellaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_981224_1 1177179.A11A3_16827 1.95e-131 392.0 COG2067@1|root,COG2067@2|Bacteria,1N0NZ@1224|Proteobacteria,1S0U8@1236|Gammaproteobacteria,1XHWR@135619|Oceanospirillales 135619|Oceanospirillales I Long-chain fatty acid transport protein - - - - - - - - - - - - Toluene_X k59_459323_1 936053.I1CUA3 2.32e-19 93.2 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_484556_1 1304883.KI912532_gene2692 4.18e-45 151.0 COG1699@1|root,COG1699@2|Bacteria,1N9E7@1224|Proteobacteria,2VUC5@28216|Betaproteobacteria,2KWTA@206389|Rhodocyclales 206389|Rhodocyclales S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW k59_19080_1 1121438.JNJA01000003_gene2853 1.33e-31 126.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QYEN@1224|Proteobacteria,42ZZD@68525|delta/epsilon subdivisions,2WVEH@28221|Deltaproteobacteria,2MHIW@213115|Desulfovibrionales 28221|Deltaproteobacteria L TOPRIM - - - - - - - - - - - - - k59_620699_1 633697.EubceDRAFT1_2161 2.16e-24 102.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,25UQE@186806|Eubacteriaceae 186801|Clostridia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_943980_1 1144319.PMI16_01589 2e-11 61.6 COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2VSD1@28216|Betaproteobacteria,474HS@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix, mercury resistance cueR - - ko:K19591,ko:K19592 - M00768,M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_943980_2 1223521.BBJX01000007_gene1538 1.76e-50 168.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,4AB3J@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the arginase family rocF - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 ko:K01476,ko:K01480,ko:K12255,ko:K18459 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00133,M00134 R00551,R01157,R01990 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_981230_2 1149133.ppKF707_2677 5.51e-47 164.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,1RZG1@1236|Gammaproteobacteria,1YJ82@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_352082_1 375286.mma_2074 3.3e-137 407.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472MA@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter yheS - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_162104_1 1205681.CALW02000045_gene1249 1.08e-16 81.6 COG3756@1|root,COG3756@2|Bacteria,1QYEJ@1224|Proteobacteria,2UKMJ@28211|Alphaproteobacteria,48TGW@772|Bartonellaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_1019039_1 583355.Caka_1039 2.51e-14 76.6 COG3119@1|root,COG3119@2|Bacteria,46S9C@74201|Verrucomicrobia 74201|Verrucomicrobia P PFAM sulfatase - - - - - - - - - - - - DUF4994,Sulfatase k59_90417_1 426117.M446_2057 2.02e-43 161.0 COG3300@1|root,COG4191@1|root,COG3300@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JST2@119045|Methylobacteriaceae 28211|Alphaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,MHYT,PAS,PAS_4,PAS_9,Response_reg k59_378182_1 614083.AWQR01000009_gene707 4.76e-76 254.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,4ABZ1@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_1058213_1 365044.Pnap_3001 1.85e-96 285.0 COG1335@1|root,COG1335@2|Bacteria,1RARV@1224|Proteobacteria,2VQ7T@28216|Betaproteobacteria,4ADTK@80864|Comamonadaceae 28216|Betaproteobacteria Q isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase k59_1058213_2 748247.AZKH_4387 2.31e-17 78.6 COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2VVGP@28216|Betaproteobacteria,2KX6M@206389|Rhodocyclales 206389|Rhodocyclales K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_19102_1 1000565.METUNv1_03416 6.08e-83 275.0 COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_695884_1 595537.Varpa_2748 1.88e-32 129.0 28IJ1@1|root,2Z8K0@2|Bacteria,1R5PC@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_484592_1 1156937.MFUM_230019 3.87e-10 62.8 COG4775@1|root,COG4775@2|Bacteria,46S5F@74201|Verrucomicrobia,37GCF@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1019055_1 614083.AWQR01000009_gene600 2.27e-95 293.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VN72@28216|Betaproteobacteria 28216|Betaproteobacteria M Pfam Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721,ko:K00786 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA,PMT_2 k59_1058235_1 1122951.ATUE01000005_gene1865 4.77e-104 305.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,3NITT@468|Moraxellaceae 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_229383_1 1123367.C666_07630 6.68e-29 119.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_674088_1 1198452.Jab_2c07990 1.19e-83 263.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria,473YM@75682|Oxalobacteraceae 28216|Betaproteobacteria M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_55476_1 614083.AWQR01000032_gene2903 7.4e-98 315.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,4AA8U@80864|Comamonadaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_674093_1 1454004.AW11_03592 8.19e-19 84.3 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,1KQEQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria Q Secondary metabolites biosynthesis, transport, and catabolism ttg2B - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_674093_2 1485544.JQKP01000001_gene1099 5.48e-58 187.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,44VBC@713636|Nitrosomonadales 28216|Betaproteobacteria Q ABC transporter ttg2A - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_695903_1 931627.MycrhDRAFT_0286 1.46e-15 83.6 COG4934@1|root,COG4934@2|Bacteria,2GMZ8@201174|Actinobacteria,23D3H@1762|Mycobacteriaceae 201174|Actinobacteria O Peptidase S53 - - - - - - - - - - - - Peptidase_S8,Pro-kuma_activ k59_20906_1 1183438.GKIL_2517 3.88e-45 161.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_556637_1 640081.Dsui_0553 4.06e-86 256.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,2VQYS@28216|Betaproteobacteria,2KWCX@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function, DUF269 - - - - - - - - - - - - DUF269 k59_733944_1 506534.Rhein_3797 9.65e-14 76.6 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1S2ZF@1236|Gammaproteobacteria,1X2PF@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_57221_1 1349767.GJA_2273 2.56e-110 337.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,2VI36@28216|Betaproteobacteria,472VZ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Isocitrate dehydrogenase icd2 - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_163806_1 399795.CtesDRAFT_PD5024 2.92e-29 112.0 COG1846@1|root,COG1846@2|Bacteria,1RCY7@1224|Proteobacteria,2VSV9@28216|Betaproteobacteria,4AERH@80864|Comamonadaceae 28216|Betaproteobacteria K TIGRFAM homoprotocatechuate degradation operon regulator, HpaR - - - - - - - - - - - - MarR,MarR_2 k59_807640_1 614083.AWQR01000001_gene3064 5.71e-113 335.0 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,2VMTI@28216|Betaproteobacteria 28216|Betaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_697472_1 1198452.Jab_1c05520 6.75e-66 202.0 COG2165@1|root,COG2165@2|Bacteria,1N0C2@1224|Proteobacteria,2VVJ8@28216|Betaproteobacteria,474GX@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein I gspI - - ko:K02458 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSI k59_697472_2 760117.JN27_21560 1.46e-37 130.0 COG2165@1|root,COG2165@2|Bacteria,1N8AD@1224|Proteobacteria,2VWBA@28216|Betaproteobacteria,474NB@75682|Oxalobacteraceae 28216|Betaproteobacteria U Type II transport protein GspH gspH - - ko:K02457 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspH,N_methyl k59_533764_1 640512.BC1003_4483 2.11e-26 103.0 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,1K8TY@119060|Burkholderiaceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_533764_2 421052.F945_02110 3.29e-08 53.5 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,1S8UB@1236|Gammaproteobacteria,3NNGU@468|Moraxellaceae 1236|Gammaproteobacteria S Transporter Component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_588343_1 204773.HEAR1750 1.73e-23 98.6 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,473C8@75682|Oxalobacteraceae 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_945490_1 395495.Lcho_3605 1.45e-93 288.0 COG0001@1|root,COG0001@2|Bacteria,1QVPQ@1224|Proteobacteria,2WHQE@28216|Betaproteobacteria 28216|Betaproteobacteria H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_92386_1 1236000.L0AQQ0_9CAUD 1.28e-103 317.0 4QGM3@10239|Viruses,4QYG4@35237|dsDNA viruses no RNA stage,4QPTC@28883|Caudovirales,4QJW3@10662|Myoviridae 10662|Myoviridae S Pfam:Terminase_6C - - - - - - - - - - - - - k59_92386_3 104623.Ser39006_02622 9.68e-37 140.0 COG3728@1|root,COG3728@2|Bacteria,1R986@1224|Proteobacteria,1RYYD@1236|Gammaproteobacteria,4046Q@613|Serratia 1236|Gammaproteobacteria L terminase small subunit - - - - - - - - - - - - Terminase_2 k59_716499_2 1000565.METUNv1_03837 5.47e-38 138.0 COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_787960_1 1121921.KB898706_gene3176 9.12e-30 122.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB k59_1037664_1 1000565.METUNv1_03288 2.47e-149 424.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,2KUWU@206389|Rhodocyclales 206389|Rhodocyclales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_503061_1 1123229.AUBC01000004_gene3017 5.58e-180 511.0 COG0037@1|root,COG0037@2|Bacteria,1MVXT@1224|Proteobacteria,2U8J4@28211|Alphaproteobacteria,3K5WN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria D tRNA processing - - - - - - - - - - - - - k59_503061_2 994573.T472_0216395 1.84e-07 53.1 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,36I01@31979|Clostridiaceae 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_181663_1 543728.Vapar_4217 3e-50 159.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,4AEWJ@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_181663_2 232721.Ajs_0843 1.25e-26 107.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,4AA8G@80864|Comamonadaceae 28216|Betaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1108537_1 1000565.METUNv1_00396 1.48e-199 578.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,2KVHX@206389|Rhodocyclales 206389|Rhodocyclales C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_965716_1 402626.Rpic_2703 2.86e-90 276.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,1K4TY@119060|Burkholderiaceae 28216|Betaproteobacteria E Aminotransferase argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_324575_1 1113547.A0A060D5T9_9CAUD 1.12e-20 100.0 4QAY9@10239|Viruses,4QV7W@35237|dsDNA viruses no RNA stage,4QPAN@28883|Caudovirales,4QNMK@10744|Podoviridae 10744|Podoviridae S hydrolase activity, acting on acid anhydrides - - - - - - - - - - - - - k59_503075_1 1121920.AUAU01000013_gene1713 4.04e-33 126.0 COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_503075_2 926566.Terro_1748 2.71e-05 47.4 COG0845@1|root,COG0845@2|Bacteria,3Y2XR@57723|Acidobacteria,2JHTV@204432|Acidobacteriia 204432|Acidobacteriia M Efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_431559_1 614083.AWQR01000014_gene2434 1.38e-35 126.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,4AAAK@80864|Comamonadaceae 28216|Betaproteobacteria E HAD-superfamily hydrolase, subfamily IB, PSPase-like - - - - - - - - - - - - HAD k59_431559_2 614083.AWQR01000014_gene2433 3.73e-53 172.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,4A9X0@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the DnaA family hda - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_109230_1 1000565.METUNv1_02690 1.86e-53 175.0 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,2KV0G@206389|Rhodocyclales 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_38300_1 1217710.F969_02194 3.53e-69 221.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,3NJ7B@468|Moraxellaceae 1236|Gammaproteobacteria S hydrolase of the alpha beta-hydrolase fold - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 k59_216183_1 1000565.METUNv1_02379 4.11e-37 136.0 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VT7G@28216|Betaproteobacteria,2KWQS@206389|Rhodocyclales 206389|Rhodocyclales S Sel1 domain-containing protein repeat-containing protein - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_181682_1 395495.Lcho_1248 1.53e-51 176.0 COG0415@1|root,COG0415@2|Bacteria,1MX6J@1224|Proteobacteria,2VK7R@28216|Betaproteobacteria,1KNC4@119065|unclassified Burkholderiales 28216|Betaproteobacteria H DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_181682_2 757424.Hsero_0417 2e-57 191.0 COG0415@1|root,COG0415@2|Bacteria,1MUKB@1224|Proteobacteria,2VND9@28216|Betaproteobacteria 28216|Betaproteobacteria L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - FAD_binding_7 k59_751637_1 1492737.FEM08_05530 1.36e-13 70.1 COG1612@1|root,COG1612@2|Bacteria,4NIT1@976|Bacteroidetes,1HXU5@117743|Flavobacteriia,2NT30@237|Flavobacterium 976|Bacteroidetes O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_751637_2 761193.Runsl_3555 2.7e-57 198.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47JC4@768503|Cytophagia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_109238_1 640081.Dsui_0130 1.5e-142 426.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales 206389|Rhodocyclales C Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_894837_1 1379698.RBG1_1C00001G1060 8.45e-36 140.0 COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_503103_1 1000565.METUNv1_02284 1.43e-89 263.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2VRAK@28216|Betaproteobacteria,2KWAX@206389|Rhodocyclales 206389|Rhodocyclales J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_537364_1 1121957.ATVL01000009_gene1161 7.47e-78 253.0 COG2273@1|root,COG4225@1|root,COG2273@2|Bacteria,COG4225@2|Bacteria,4NF91@976|Bacteroidetes,47MDE@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 16 - - - - - - - - - - - - DUF1735,Glyco_hydro_16,Glyco_hydro_43 k59_823166_1 397945.Aave_1719 4.81e-18 79.3 2E7TE@1|root,3328J@2|Bacteria,1N6RC@1224|Proteobacteria,2VX0Z@28216|Betaproteobacteria,4AIIF@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - BrnA_antitoxin k59_823166_2 742159.HMPREF0004_2557 1.11e-26 101.0 2E722@1|root,331KP@2|Bacteria,1N7HW@1224|Proteobacteria,2W5PM@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_431586_1 397945.Aave_3691 5.74e-46 150.0 COG4701@1|root,COG4701@2|Bacteria,1N5G9@1224|Proteobacteria,2VU6Y@28216|Betaproteobacteria,4AEVQ@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 k59_431586_2 338969.Rfer_2912 8.48e-05 43.5 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,4AAYI@80864|Comamonadaceae 28216|Betaproteobacteria M Peptidase M23B - - 3.4.24.75 ko:K08259 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_144947_1 935848.JAEN01000006_gene3234 4.56e-85 258.0 COG4176@1|root,COG4176@2|Bacteria,1R5ZR@1224|Proteobacteria,2UNTD@28211|Alphaproteobacteria,2PUUA@265|Paracoccus 28211|Alphaproteobacteria E Binding-protein-dependent transport system inner membrane component - - - ko:K02001 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1 k59_717325_1 1000565.METUNv1_03900 1.89e-134 417.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,2KUFW@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_1075264_1 1198452.Jab_2c08670 1.32e-55 176.0 COG1522@1|root,COG1522@2|Bacteria,1RCWU@1224|Proteobacteria,2VQPQ@28216|Betaproteobacteria,4775R@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix ASNC type lrp2 - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 k59_823814_2 1000565.METUNv1_03660 8.99e-16 80.5 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,2KVXA@206389|Rhodocyclales 206389|Rhodocyclales S cytochrome d1 heme nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_788807_1 1132855.KB913035_gene2624 1.19e-30 122.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria,2KKGD@206350|Nitrosomonadales 206350|Nitrosomonadales NU type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N_2 k59_467197_1 360910.BAV0433 4.71e-16 84.3 29X6M@1|root,30IVR@2|Bacteria,1QZD3@1224|Proteobacteria,2WHJQ@28216|Betaproteobacteria,3T88P@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_325580_1 1123504.JQKD01000034_gene2739 8.87e-15 75.5 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,2VW0N@28216|Betaproteobacteria,4AFJE@80864|Comamonadaceae 28216|Betaproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_253328_1 987059.RBXJA2T_19081 2.7e-73 227.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,1KJ8F@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_253328_2 1504672.669786264 5.12e-71 229.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,4A9JW@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1002178_1 1123053.AUDG01000089_gene2264 1.34e-40 149.0 2DB7W@1|root,2Z7P1@2|Bacteria,1N65F@1224|Proteobacteria,1RQEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4331) - - - - - - - - - - - - DUF4331 k59_680780_1 1217718.ALOU01000002_gene4639 2.24e-21 93.6 COG0470@1|root,COG0470@2|Bacteria,1MVEE@1224|Proteobacteria,2VP7K@28216|Betaproteobacteria,1KBKF@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase III - - - - - - - - - - - - - k59_752290_1 985665.HPL003_16705 2.35e-79 245.0 COG4209@1|root,COG4209@2|Bacteria,1TQ64@1239|Firmicutes,4HA17@91061|Bacilli,26RH9@186822|Paenibacillaceae 91061|Bacilli G ABC-type polysaccharide transport system, permease component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 k59_467214_1 1000565.METUNv1_03661 2.52e-94 277.0 COG3832@1|root,COG3832@2|Bacteria,1RD9A@1224|Proteobacteria,2VQDY@28216|Betaproteobacteria,2KWWI@206389|Rhodocyclales 206389|Rhodocyclales S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_752291_1 1000565.METUNv1_03053 2.26e-135 394.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,2KUA4@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DNA photolyase family phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_752291_2 1000565.METUNv1_03054 4.21e-64 204.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VRZ3@28216|Betaproteobacteria,2KX03@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_39230_1 414996.IL38_12630 2.02e-06 47.8 COG2608@1|root,COG2608@2|Bacteria,2GQK5@201174|Actinobacteria 201174|Actinobacteria P PFAM Heavy metal transport detoxification protein - - - - - - - - - - - - HMA k59_182728_1 1000565.METUNv1_00736 2.52e-35 129.0 COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,2VJ0W@28216|Betaproteobacteria,2KV1F@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_182728_2 1000565.METUNv1_00737 8.64e-168 485.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KVNF@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_538042_1 1000565.METUNv1_03992 2.59e-159 486.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971,DUF748 k59_504141_1 1000565.METUNv1_00865 1.7e-134 389.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,2KUU6@206389|Rhodocyclales 206389|Rhodocyclales Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_504141_2 1000565.METUNv1_00866 1.94e-51 171.0 COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,2VH2D@28216|Betaproteobacteria,2KVGU@206389|Rhodocyclales 28216|Betaproteobacteria E glycosyl transferase family trpD3 - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_467228_1 398720.MED217_04937 7.41e-24 100.0 2AFQQ@1|root,315SK@2|Bacteria,4NJD4@976|Bacteroidetes,1HWPU@117743|Flavobacteriia,2XIYQ@283735|Leeuwenhoekiella 976|Bacteroidetes S HNH endonuclease - - - - - - - - - - - - HNH_3,NUMOD4 k59_182741_1 640081.Dsui_0572 1.45e-57 182.0 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2VT5X@28216|Betaproteobacteria,2KWJT@206389|Rhodocyclales 206389|Rhodocyclales S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_182741_2 269482.Bcep1808_5981 1.22e-23 91.3 COG2440@1|root,COG2440@2|Bacteria,1RHTX@1224|Proteobacteria,2VSXZ@28216|Betaproteobacteria,1K8HQ@119060|Burkholderiaceae 28216|Betaproteobacteria C Could be a 3Fe-4S cluster-containing protein fixX - - ko:K03855 - - - - ko00000 - - - ETF_QO k59_253364_1 83406.HDN1F_34040 1.02e-17 80.9 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,1RMK7@1236|Gammaproteobacteria,1J4NB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_253364_2 1122951.ATUE01000007_gene653 5.39e-61 194.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,3NIQV@468|Moraxellaceae 1236|Gammaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_325609_2 367299.JOEE01000001_gene1959 6.34e-64 229.0 COG0467@1|root,COG0467@2|Bacteria,2HFY5@201174|Actinobacteria,4FJTN@85021|Intrasporangiaceae 201174|Actinobacteria T AAA domain - - - - - - - - - - - - AAA_25 k59_396228_1 1095769.CAHF01000010_gene1203 3.03e-152 440.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,472A6@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_752301_1 1122951.ATUE01000007_gene550 1.51e-157 450.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,3NJYR@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_145580_1 1000565.METUNv1_02134 8.56e-78 234.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,2KWI1@206389|Rhodocyclales 206389|Rhodocyclales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_538049_2 1123359.AUIQ01000001_gene1970 2.28e-13 71.6 COG1555@1|root,COG1596@1|root,COG1555@2|Bacteria,COG1596@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,4B34A@81852|Enterococcaceae 91061|Bacilli L SLBB domain comEA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k59_823866_1 1000565.METUNv1_00133 4.42e-193 541.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,2KV6H@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_1109205_1 1121033.AUCF01000004_gene5040 6.26e-36 134.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,2JQAZ@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1109205_2 414684.RC1_1192 6.6e-29 113.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2JPW2@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_647002_1 1004149.AFOE01000033_gene730 5.08e-11 69.7 COG2374@1|root,COG2374@2|Bacteria 2|Bacteria - - - - - ko:K07004 - - - - ko00000 - - - Endonuclease_1,Exo_endo_phos,LTD,SprB,fn3 k59_216742_1 395492.Rleg2_4886 1.1e-53 178.0 COG4177@1|root,COG4177@2|Bacteria,1NY9G@1224|Proteobacteria,2U2B5@28211|Alphaproteobacteria,4BBPP@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_608972_1 1000565.METUNv1_01286 1.98e-75 229.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,2KW1V@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_608972_2 1000565.METUNv1_01287 7.67e-229 635.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,2KUHP@206389|Rhodocyclales 206389|Rhodocyclales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_608972_3 1000565.METUNv1_01288 2.7e-89 267.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,2KV6X@206389|Rhodocyclales 206389|Rhodocyclales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_39259_1 1000565.METUNv1_03226 5.9e-217 611.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,2KV5T@206389|Rhodocyclales 206389|Rhodocyclales C Nickel-dependent hydrogenase - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_895804_1 338969.Rfer_3762 1.9e-81 260.0 COG1538@1|root,COG2885@1|root,COG1538@2|Bacteria,COG2885@2|Bacteria,1MYX2@1224|Proteobacteria,2VKDN@28216|Betaproteobacteria,4ABJI@80864|Comamonadaceae 28216|Betaproteobacteria MU type I secretion outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP,OmpA k59_73881_1 1000565.METUNv1_03316 3.17e-145 422.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,2KUVM@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_253375_1 1000565.METUNv1_02102 1.5e-211 591.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,2KU9F@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_253375_2 1000565.METUNv1_02101 4.74e-44 145.0 2AF5U@1|root,3154P@2|Bacteria,1PV4V@1224|Proteobacteria,2WB3A@28216|Betaproteobacteria,2KXID@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_253375_3 1000565.METUNv1_02099 1.42e-09 57.4 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_717396_1 1198452.Jab_1c07470 8.01e-59 183.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,4744D@75682|Oxalobacteraceae 28216|Betaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_717396_2 1288494.EBAPG3_30030 2.9e-34 120.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,37389@32003|Nitrosomonadales 28216|Betaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_182764_1 333138.LQ50_21245 1.35e-11 70.5 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,4HCST@91061|Bacilli,1ZCPN@1386|Bacillus 91061|Bacilli T Sigma-54 interaction domain atoC - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_895805_1 391735.Veis_3982 2.91e-130 374.0 COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria,4AC2K@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR gno2 - - - - - - - - - - - adh_short_C2 k59_467250_1 1122951.ATUE01000005_gene2236 3.69e-59 197.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,3NJ8X@468|Moraxellaceae 1236|Gammaproteobacteria J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_578881_1 1123248.KB893315_gene2998 1.81e-73 242.0 COG3391@1|root,COG3391@2|Bacteria,4NER2@976|Bacteroidetes,1IQ4S@117747|Sphingobacteriia 976|Bacteroidetes M 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase,Phosphoesterase k59_795705_1 1177179.A11A3_00630 2.9e-50 167.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1XIR9@135619|Oceanospirillales 135619|Oceanospirillales P Sulfurtransferase glpE - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_193498_1 1088721.NSU_1243 9.45e-17 78.6 29W19@1|root,30HJP@2|Bacteria,1R60N@1224|Proteobacteria,2TV4D@28211|Alphaproteobacteria,2K2WI@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_81069_1 1000565.METUNv1_03810 2.08e-117 338.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,2KV6M@206389|Rhodocyclales 206389|Rhodocyclales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_81069_2 1000565.METUNv1_03811 1.91e-135 385.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,2KVUE@206389|Rhodocyclales 206389|Rhodocyclales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_81069_3 522306.CAP2UW1_2737 1.25e-164 467.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1KPSD@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_151813_1 1123053.AUDG01000002_gene2801 2.75e-15 77.8 COG5001@1|root,COG5001@2|Bacteria,1PSFV@1224|Proteobacteria,1RY72@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_151813_2 1215092.PA6_005_02070 9.64e-24 106.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1YE9Y@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T CHASE - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - CHASE,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,TarH k59_865494_1 1137799.GZ78_09365 3.17e-12 67.8 arCOG09463@1|root,2Z8U6@2|Bacteria,1NHE7@1224|Proteobacteria,1RY5W@1236|Gammaproteobacteria,1XII0@135619|Oceanospirillales 135619|Oceanospirillales S DNA-sulfur modification-associated - - - ko:K19169 - - - - ko00000,ko02048 - - - DndB k59_865494_2 1439940.BAY1663_01770 3.72e-38 140.0 COG0175@1|root,COG0175@2|Bacteria,1MXNT@1224|Proteobacteria,1RYKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH PFAM Phosphoadenosine phosphosulfate reductase - - - ko:K19170 - - - - ko00000,ko02048 - - - PAPS_reduct k59_193545_1 1000565.METUNv1_01948 8.93e-64 207.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,2KUS9@206389|Rhodocyclales 206389|Rhodocyclales C glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_658189_1 614083.AWQR01000014_gene2426 5.97e-11 59.3 COG1256@1|root,COG1256@2|Bacteria,1NMP9@1224|Proteobacteria,2VVX1@28216|Betaproteobacteria,4AFNB@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar basal body rod protein - - - - - - - - - - - - Flg_bb_rod,Flg_bbr_C k59_658189_2 1532557.JL37_19995 3.15e-41 157.0 COG0477@1|root,COG0477@2|Bacteria,1QTTP@1224|Proteobacteria,2WGJR@28216|Betaproteobacteria,3T28B@506|Alcaligenaceae 28216|Betaproteobacteria EGP the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1044545_1 1000565.METUNv1_01090 1.58e-44 145.0 COG4378@1|root,COG4378@2|Bacteria,1N83H@1224|Proteobacteria,2VXC4@28216|Betaproteobacteria,2KXEK@206389|Rhodocyclales 206389|Rhodocyclales S Uncharacterized protein conserved in bacteria (DUF2325) - - - - - - - - - - - - DUF2325 k59_1114319_1 1144342.PMI40_04749 1.26e-17 79.3 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase k59_296805_1 316067.Geob_3517 8.73e-99 298.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43T7M@69541|Desulfuromonadales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1044548_1 1348657.M622_17120 5.33e-70 218.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KW4E@206389|Rhodocyclales 206389|Rhodocyclales S membrane - - - - - - - - - - - - UPF0016 k59_543790_1 1121035.AUCH01000027_gene3388 1.61e-57 197.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria 28216|Betaproteobacteria Q PFAM Hemolysin-type calcium-binding - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_443939_1 1002339.HMPREF9373_0677 1.03e-16 81.3 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,3NNUJ@468|Moraxellaceae 1236|Gammaproteobacteria C cytochrome C, class I cyc - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - Cytochrome_CBB3 k59_443939_2 748247.AZKH_0334 1.09e-15 72.0 COG3245@1|root,COG3245@2|Bacteria,1RG2V@1224|Proteobacteria,2VS0Q@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 k59_722979_1 1346330.M472_06295 1.95e-84 267.0 COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,1IQXV@117747|Sphingobacteriia 976|Bacteroidetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_336142_1 1000565.METUNv1_01937 2.95e-305 851.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KU7U@206389|Rhodocyclales 206389|Rhodocyclales M penicillin-binding protein 1A mcrA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_336157_2 365046.Rta_07070 5.77e-37 140.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,4AB4U@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_116063_1 614083.AWQR01000041_gene814 5.42e-102 303.0 COG2404@1|root,COG2404@2|Bacteria,1QW0R@1224|Proteobacteria,2VJE0@28216|Betaproteobacteria,4AC8Q@80864|Comamonadaceae 28216|Betaproteobacteria S COG0618 Exopolyphosphatase-related proteins - - - - - - - - - - - - - k59_903098_1 672.VV93_v1c35920 3.81e-56 186.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1XW0E@135623|Vibrionales 135623|Vibrionales L other refs with uncharged polar side chains (S Ser or T Thr), and there are a few more such examples along the aa-chain (ex R Arg changed with H His) - - - - - - - - - - - - HTH_38,rve k59_260229_1 1000565.METUNv1_00798 1.11e-18 82.4 COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,2KVQX@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_260229_2 1000565.METUNv1_00799 2.33e-63 207.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,2KU9G@206389|Rhodocyclales 206389|Rhodocyclales H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - - - - - - - - - - - Carb_kinase,YjeF_N k59_193608_1 748247.AZKH_p0143 3.16e-07 51.2 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,2KUYY@206389|Rhodocyclales 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_193608_2 748247.AZKH_p0144 1.49e-13 70.5 COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria 1224|Proteobacteria H trimethylamine methyltransferase mttB2 - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_1114348_1 1000565.METUNv1_02528 1.81e-83 272.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2VJF3@28216|Betaproteobacteria,2KW03@206389|Rhodocyclales 206389|Rhodocyclales L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_578937_1 1125712.HMPREF1316_1538 9.76e-07 55.8 29XHN@1|root,30J8C@2|Bacteria,2HWFG@201174|Actinobacteria,4CYBW@84998|Coriobacteriia 84998|Coriobacteriia - - - - - - - - - - - - - - - k59_367726_1 313606.M23134_02237 0.000631 47.8 COG3209@1|root,COG3291@1|root,COG3386@1|root,COG4932@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG4932@2|Bacteria,4NJ9V@976|Bacteroidetes,47N8F@768503|Cytophagia 976|Bacteroidetes G Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - CHU_C,PKD k59_865572_1 1268622.AVS7_02460 2.04e-108 325.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,4AAZB@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein dld - 1.1.2.4,1.1.5.12 ko:K00102,ko:K03777 ko00620,ko01120,map00620,map01120 - R00197,R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_193638_1 1000565.METUNv1_00694 4.54e-08 53.1 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,2KU6U@206389|Rhodocyclales 206389|Rhodocyclales P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_193638_2 1000565.METUNv1_02779 2.39e-40 137.0 COG1846@1|root,COG1846@2|Bacteria,1N0TW@1224|Proteobacteria,2W2KE@28216|Betaproteobacteria 28216|Betaproteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - - k59_221068_1 85643.Tmz1t_2622 3.11e-114 342.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,2KVB1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_336219_1 977880.RALTA_A2963 2.67e-38 130.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,1K762@119060|Burkholderiaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_261185_1 1000565.METUNv1_03063 1.23e-163 465.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,2KVNV@206389|Rhodocyclales 206389|Rhodocyclales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_261185_2 1000565.METUNv1_03064 4.74e-10 58.9 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,2KUBC@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_516459_1 335283.Neut_2286 3.95e-37 131.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,3736W@32003|Nitrosomonadales 28216|Betaproteobacteria M Peptidyl-prolyl cis-trans isomerase fkpA - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_516459_2 675814.VIC_003895 3.5e-09 57.4 COG1451@1|root,COG1451@2|Bacteria,1RDJ9@1224|Proteobacteria,1S45M@1236|Gammaproteobacteria,1XTK3@135623|Vibrionales 135623|Vibrionales S Metal-dependent hydrolase ygjP - - ko:K07043 - - - - ko00000 - - - DUF45 k59_659897_1 1500890.JQNL01000001_gene1069 6.25e-55 188.0 COG0369@1|root,COG0369@2|Bacteria,1MWYV@1224|Proteobacteria,1RY05@1236|Gammaproteobacteria,1X33W@135614|Xanthomonadales 135614|Xanthomonadales P Sulfite reductase, alpha subunit (Flavoprotein) - - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_1,NAD_binding_1 k59_153030_1 1005048.CFU_3214 2.51e-94 283.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2VIET@28216|Betaproteobacteria,473KH@75682|Oxalobacteraceae 28216|Betaproteobacteria O Aspartyl Asparaginyl beta-hydroxylase aspH - - ko:K12979 - - - - ko00000,ko01000,ko01005 - - - Asp_Arg_Hydrox k59_297819_1 754331.AEME01000001_gene2548 1.93e-53 182.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,3XNNU@561|Escherichia 1236|Gammaproteobacteria S Predicted permease YjgP/YjgQ family lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_297819_2 322710.Avin_44330 7.05e-45 157.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Permease lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_972555_2 1279019.ARQK01000027_gene2458 3.24e-166 477.0 COG1672@1|root,COG1672@2|Bacteria,1MWJX@1224|Proteobacteria,1RWRA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Archaea bacterial proteins of unknown function - - - ko:K06921 - - - - ko00000 - - - ATPase_2,DUF234 k59_1010711_1 1000565.METUNv1_01300 7.44e-75 229.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1010711_2 1000565.METUNv1_01299 1.71e-130 376.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,2KU95@206389|Rhodocyclales 206389|Rhodocyclales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_82066_1 999541.bgla_2g16570 1.06e-11 64.3 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VNHN@28216|Betaproteobacteria,1JZWK@119060|Burkholderiaceae 28216|Betaproteobacteria K GntR family transcriptional regulator - - - ko:K03486,ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_1087875_1 864051.BurJ1DRAFT_1698 1.5e-10 64.3 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,2VR41@28216|Betaproteobacteria,1KNIP@119065|unclassified Burkholderiales 28216|Betaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_903878_1 220664.PFL_5867 2.06e-92 287.0 COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,1RPS8@1236|Gammaproteobacteria,1YMQ7@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E GMC family - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_936931_2 305700.B447_11852 8.69e-32 121.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,2KVGY@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_579717_1 232721.Ajs_1080 4.91e-109 328.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,4AA7T@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_687187_1 1122176.KB903598_gene4693 2.32e-48 176.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,4PHZG@976|Bacteroidetes,1IW5N@117747|Sphingobacteriia 976|Bacteroidetes O Pregnancy-associated plasma protein-A - - - - - - - - - - - - CHU_C,Peptidase_M43 k59_153067_1 13690.CP98_03708 1.44e-59 196.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2U82T@28211|Alphaproteobacteria 28211|Alphaproteobacteria L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_153077_1 1000565.METUNv1_03313 7.79e-159 460.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,2KUXG@206389|Rhodocyclales 206389|Rhodocyclales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_153077_2 1000565.METUNv1_03314 3.07e-05 45.1 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales 206389|Rhodocyclales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_544859_2 110319.CF8_0973 1.5e-20 86.3 COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4DQQA@85009|Propionibacteriales 201174|Actinobacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03664 - - - - ko00000 - - - SmpB k59_866629_1 1000565.METUNv1_00622 4.22e-92 281.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_936960_1 1122939.ATUD01000016_gene1837 1.24e-23 100.0 COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4CR9U@84995|Rubrobacteria 84995|Rubrobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_936960_2 388399.SSE37_23959 4.88e-10 57.8 COG2841@1|root,COG2841@2|Bacteria,1NNR7@1224|Proteobacteria,2UFB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - ko:K09794 - - - - ko00000 - - - DUF465 k59_46808_1 159087.Daro_0137 2.25e-103 304.0 COG0614@1|root,COG0614@2|Bacteria,1PKNF@1224|Proteobacteria,2VMK5@28216|Betaproteobacteria,2KVRK@206389|Rhodocyclales 206389|Rhodocyclales P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_368904_1 1157708.KB907461_gene1614 1.68e-13 68.2 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2VIX4@28216|Betaproteobacteria,4AAM1@80864|Comamonadaceae 28216|Betaproteobacteria S urea ABC transporter, ATP-binding protein - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C k59_368904_2 1157708.KB907461_gene1615 4.19e-77 235.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,4A9PJ@80864|Comamonadaceae 1224|Proteobacteria E ABC transporter, ATP-binding protein - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_758406_1 1198452.Jab_1c25710 1.25e-64 205.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,472PA@75682|Oxalobacteraceae 28216|Betaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_758406_2 1198452.Jab_1c25720 6.98e-08 53.5 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,473AF@75682|Oxalobacteraceae 28216|Betaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_221875_1 1000565.METUNv1_04030 2.92e-196 569.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KVQM@206389|Rhodocyclales 206389|Rhodocyclales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1045367_1 1122951.ATUE01000009_gene439 5.13e-154 461.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,3NIHR@468|Moraxellaceae 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_724080_2 411154.GFO_2025 1.49e-61 202.0 COG0673@1|root,COG0673@2|Bacteria,4NK71@976|Bacteroidetes,1I9AX@117743|Flavobacteriia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_337812_1 159087.Daro_2515 2.56e-135 393.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,2KUEA@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_832479_1 1279009.ADICEAN_00552 4.33e-144 417.0 COG0399@1|root,COG0399@2|Bacteria,4NEIU@976|Bacteroidetes,47JAI@768503|Cytophagia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family wecE - 2.6.1.59 ko:K02805 - - - - ko00000,ko01000,ko01007 - - - DegT_DnrJ_EryC1 k59_1010776_1 1000565.METUNv1_03342 2.01e-68 213.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2VRFJ@28216|Betaproteobacteria,2KW3Z@206389|Rhodocyclales 206389|Rhodocyclales HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_739589_1 1000565.METUNv1_02644 1.9e-98 298.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,2KVFK@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar hook protein FlgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_950750_1 925409.KI911562_gene815 1.51e-82 249.0 COG3201@1|root,COG3201@2|Bacteria,4NFJI@976|Bacteroidetes,1ISA7@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM Nicotinamide mononucleotide transporter PnuC pnuC - - ko:K03811 - - - - ko00000,ko02000 4.B.1.1 - - NMN_transporter k59_134160_1 232721.Ajs_0879 6.26e-38 134.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,4AA1H@80864|Comamonadaceae 28216|Betaproteobacteria H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_134160_2 1100721.ALKO01000019_gene1367 6.25e-05 45.8 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,4A9Z3@80864|Comamonadaceae 28216|Betaproteobacteria I phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_772442_1 1000565.METUNv1_02635 6.06e-69 216.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VNCG@28216|Betaproteobacteria,2KV2Y@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor motC - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_390172_1 305700.B447_11892 3.92e-54 192.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVC7@206389|Rhodocyclales 206389|Rhodocyclales T PAC sensor-containing diguanylate cyclase phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS,PAS_9 k59_1070639_1 614083.AWQR01000052_gene3404 1.64e-12 66.6 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,4ABGU@80864|Comamonadaceae 28216|Betaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1070639_2 232721.Ajs_0893 5.76e-93 275.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,4ABYV@80864|Comamonadaceae 28216|Betaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_1131124_1 864051.BurJ1DRAFT_4600 7.36e-23 102.0 COG0810@1|root,COG3064@1|root,COG0810@2|Bacteria,COG3064@2|Bacteria,1REKC@1224|Proteobacteria,2VRYT@28216|Betaproteobacteria 28216|Betaproteobacteria M TonB C terminal - - - - - - - - - - - - TonB_2 k59_494140_1 399795.CtesDRAFT_PD2836 7.83e-16 75.9 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,4ACEV@80864|Comamonadaceae 28216|Betaproteobacteria T PrkA serine kinase prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_494140_2 1000565.METUNv1_00482 3.13e-82 255.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2VJE2@28216|Betaproteobacteria,2KV9U@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_417924_2 1280676.AUJO01000001_gene2458 0.000153 49.7 COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia,4BWKI@830|Butyrivibrio 186801|Clostridia N SRP54-type protein, GTPase domain flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_134188_1 1502852.FG94_01832 1.13e-14 79.0 2DZ47@1|root,34CD1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_26785_1 614083.AWQR01000009_gene578 4.32e-43 157.0 COG0457@1|root,COG0457@2|Bacteria,1MWHE@1224|Proteobacteria,2W0SA@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1070663_1 1268622.AVS7_02357 1.9e-05 44.3 2E3GE@1|root,32YF6@2|Bacteria,1N7MX@1224|Proteobacteria,2VWDH@28216|Betaproteobacteria,4AFEQ@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2188) - - - - - - - - - - - - DUF2188 k59_1070663_2 596153.Alide_0469 3.24e-109 322.0 28K7Y@1|root,2Z9VX@2|Bacteria,1QFIB@1224|Proteobacteria,2VJ3E@28216|Betaproteobacteria,4ABYE@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1131140_1 864073.HFRIS_019633 1.3e-75 237.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,472QA@75682|Oxalobacteraceae 28216|Betaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_772482_2 375286.mma_0729 7.78e-44 148.0 COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,474DW@75682|Oxalobacteraceae 28216|Betaproteobacteria S TIGRFAM phasin family protein phaP - - - - - - - - - - - Phasin_2 k59_918383_1 118005.AWNK01000004_gene1063 1.74e-50 178.0 COG0367@1|root,COG0367@2|Bacteria 2|Bacteria E asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1070699_1 742725.HMPREF9450_01025 6.71e-69 223.0 COG0162@1|root,COG0162@2|Bacteria,4NF19@976|Bacteroidetes,2FN0B@200643|Bacteroidia,22U1N@171550|Rikenellaceae 976|Bacteroidetes J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1070699_2 172045.KS04_09535 3.62e-13 73.9 COG1538@1|root,COG1538@2|Bacteria,4NKJI@976|Bacteroidetes,1HZ9D@117743|Flavobacteriia,34R9P@308865|Elizabethkingia 976|Bacteroidetes MU Outer membrane efflux protein - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - OEP k59_739668_1 469383.Cwoe_2570 3.9e-27 116.0 28JCI@1|root,2Z976@2|Bacteria,2GP7M@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1131161_1 1504672.669785112 3.1e-49 162.0 COG0411@1|root,COG0411@2|Bacteria,1P2HQ@1224|Proteobacteria,2VJN6@28216|Betaproteobacteria,4AD5K@80864|Comamonadaceae 28216|Betaproteobacteria E SMART AAA ATPase - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1131161_2 1504672.669785111 1.25e-123 356.0 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VHEN@28216|Betaproteobacteria,4ACHU@80864|Comamonadaceae 28216|Betaproteobacteria E SMART AAA ATPase - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1070718_1 596153.Alide_3649 4.47e-06 48.1 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,4AAIA@80864|Comamonadaceae 28216|Betaproteobacteria CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 ubiF - - - - - - - - - - - FAD_binding_3,SE k59_1070718_2 614083.AWQR01000029_gene2172 4.57e-72 223.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,4AASK@80864|Comamonadaceae 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_318352_1 1232683.ADIMK_2887 9.1e-61 209.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,4648S@72275|Alteromonadaceae 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_739680_2 522306.CAP2UW1_2139 3.4e-14 68.9 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,1KR0U@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_134224_1 1227261.HMPREF0043_01549 1.22e-08 62.8 COG3025@1|root,COG3025@2|Bacteria,2II2C@201174|Actinobacteria,4D46U@85005|Actinomycetales 201174|Actinobacteria S VTC domain protein - - - - - - - - - - - - VTC k59_772519_1 1313421.JHBV01000042_gene3245 1e-13 70.9 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,1IPG7@117747|Sphingobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_772519_2 1250232.JQNJ01000001_gene3805 1.65e-13 67.0 COG2259@1|root,COG2259@2|Bacteria,4NP94@976|Bacteroidetes,1I20E@117743|Flavobacteriia 976|Bacteroidetes S Doxx family - - - - - - - - - - - - DoxX k59_1132804_2 1353529.M899_1325 1.43e-07 53.5 2FCVT@1|root,344YN@2|Bacteria,1P3BD@1224|Proteobacteria,4320J@68525|delta/epsilon subdivisions,2MT76@213481|Bdellovibrionales,2WX5V@28221|Deltaproteobacteria 213481|Bdellovibrionales - - - - - - - - - - - - - - - k59_919834_1 1101195.Meth11DRAFT_2406 1.98e-12 67.4 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,2KKJD@206350|Nitrosomonadales 206350|Nitrosomonadales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_919834_4 1157708.KB907464_gene391 2.25e-13 69.7 COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2VI68@28216|Betaproteobacteria,4ACPU@80864|Comamonadaceae 28216|Betaproteobacteria P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane kdpA - 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpA k59_172099_1 1000565.METUNv1_03674 7.49e-107 318.0 COG0265@1|root,COG0265@2|Bacteria,1RHVK@1224|Proteobacteria,2VT8V@28216|Betaproteobacteria 28216|Betaproteobacteria O PFAM TPR repeat-containing protein - - - - - - - - - - - - TPR_1,TPR_16,TPR_19,TPR_8,Trypsin_2 k59_852394_1 1175306.GWL_15230 2.42e-97 289.0 COG3739@1|root,COG3739@2|Bacteria,1PMEC@1224|Proteobacteria,2VJYG@28216|Betaproteobacteria,473UG@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF817) - - - - - - - - - - - - DUF817 k59_741681_1 365046.Rta_30730 8.59e-106 313.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,4ABQ0@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM NAD-dependent glycerol-3-phosphate dehydrogenase domain protein gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_990627_2 862908.BMS_0238 9.8e-80 244.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2MT1R@213481|Bdellovibrionales,2WMR6@28221|Deltaproteobacteria 213481|Bdellovibrionales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_595108_1 614083.AWQR01000014_gene2439 1.29e-93 274.0 COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,4ADG2@80864|Comamonadaceae 28216|Betaproteobacteria J endoribonuclease L-PSP tdcF2 - - - - - - - - - - - YjgF_endoribonc k59_595108_2 614083.AWQR01000014_gene2437 1.66e-43 155.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AAGH@80864|Comamonadaceae 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406,ko:K03776,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_773882_1 1123242.JH636434_gene3240 2.95e-36 130.0 COG0500@1|root,COG2226@2|Bacteria,2J3W1@203682|Planctomycetes 203682|Planctomycetes Q Methyltransferase domain - - - - - - - - - - - - - k59_773882_2 1218074.BAXZ01000009_gene2166 0.000261 42.0 COG1846@1|root,COG1846@2|Bacteria,1NWZ4@1224|Proteobacteria,2VUJ0@28216|Betaproteobacteria,1K77P@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein emrR - - ko:K15974 - M00701 - - ko00000,ko00002,ko03000 - - - MarR,MarR_2 k59_496301_1 522306.CAP2UW1_2025 9.12e-100 307.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,1KPNB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_320019_1 1198452.Jab_2c27730 6.59e-59 186.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,472B0@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_320019_2 1198452.Jab_2c27730 2.81e-32 117.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,472B0@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_919884_1 1000565.METUNv1_03556 6.09e-92 297.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria,2KXCF@206389|Rhodocyclales 206389|Rhodocyclales M RHS Repeat - - - - - - - - - - - - RHS_repeat k59_952085_1 1408416.JNJT01000017_gene217 6.32e-10 64.3 COG0010@1|root,COG0010@2|Bacteria 2|Bacteria E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines speB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_172146_1 472759.Nhal_3652 2.78e-52 177.0 COG3156@1|root,COG3156@2|Bacteria,1RJRE@1224|Proteobacteria,1S6CB@1236|Gammaproteobacteria,1WW8Y@135613|Chromatiales 135613|Chromatiales U PFAM General secretion pathway protein K - - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_496365_1 1000565.METUNv1_01356 1.21e-69 220.0 COG0491@1|root,COG0491@2|Bacteria,1RDXA@1224|Proteobacteria,2VSBH@28216|Betaproteobacteria,2KWZP@206389|Rhodocyclales 206389|Rhodocyclales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_496365_2 1000565.METUNv1_01357 3.81e-47 154.0 2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2VX9I@28216|Betaproteobacteria,2KXMK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_852505_1 1000565.METUNv1_02081 3.66e-116 344.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,2KVNS@206389|Rhodocyclales 206389|Rhodocyclales I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_64690_1 640081.Dsui_0328 6.37e-121 363.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,2KV1E@206389|Rhodocyclales 206389|Rhodocyclales O COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_101031_2 397945.Aave_1763 1.53e-46 157.0 2E7QF@1|root,3325W@2|Bacteria,1NG25@1224|Proteobacteria,2VXH8@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - DUF968 k59_101031_3 399742.Ent638_0788 3.21e-17 80.5 2C58H@1|root,32YYI@2|Bacteria,1N7UA@1224|Proteobacteria,1S81E@1236|Gammaproteobacteria,3X2KM@547|Enterobacter 1236|Gammaproteobacteria S NinB protein ninB - - - - - - - - - - - NinB k59_101031_4 1111134.HMPREF1253_1197 1.27e-11 64.3 2E3AH@1|root,32YA0@2|Bacteria,1VGN7@1239|Firmicutes,25DV7@186801|Clostridia,22HSA@1570339|Peptoniphilaceae 186801|Clostridia S Protein of unknown function (DUF1064) - - - - - - - - - - - - DUF1064 k59_101031_7 991905.SL003B_2410 2.69e-46 174.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,4BPP7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_101031_8 1007105.PT7_P071 4.42e-61 201.0 28N2X@1|root,2ZB8P@2|Bacteria,1R4KJ@1224|Proteobacteria,2WDTP@28216|Betaproteobacteria,3T8AJ@506|Alcaligenaceae 28216|Betaproteobacteria S sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7 - - - - - - - - - - - - - k59_1132923_1 399741.Spro_1932 2.87e-40 146.0 COG3104@1|root,COG3104@2|Bacteria,1QXBE@1224|Proteobacteria,1RNVV@1236|Gammaproteobacteria,401XX@613|Serratia 1236|Gammaproteobacteria E amino acid peptide transporter ydgR - - ko:K03305,ko:K06218 - - - - ko00000,ko02048 2.A.17 - - MFS_1,PTR2 k59_741820_1 1401065.HMPREF2130_03200 2.23e-05 51.6 COG0728@1|root,COG0728@2|Bacteria,1RJ6Y@1224|Proteobacteria,2VZC8@28216|Betaproteobacteria,3T29K@506|Alcaligenaceae 28216|Betaproteobacteria S membrane - - - - - - - - - - - - MVIN k59_28425_1 387093.SUN_0335 1.93e-18 89.7 COG2931@1|root,COG2931@2|Bacteria,1NEXT@1224|Proteobacteria,42ST8@68525|delta/epsilon subdivisions,2YSXQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - DUF4214 k59_172224_1 762968.HMPREF9441_03016 9.48e-11 67.4 COG2755@1|root,COG2755@2|Bacteria,4NGW6@976|Bacteroidetes,2FN21@200643|Bacteroidia 976|Bacteroidetes E COG NOG14456 non supervised orthologous group - - - - - - - - - - - - Lipase_GDSL,Lipase_GDSL_2,LysM k59_990727_1 358220.C380_23095 6.29e-103 323.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,4A9PB@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_990737_1 279714.FuraDRAFT_2225 3.13e-89 277.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,2KQG8@206351|Neisseriales 206351|Neisseriales IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_496437_1 296591.Bpro_0208 2.33e-80 245.0 COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria,4AAMQ@80864|Comamonadaceae 28216|Betaproteobacteria K Two component transcriptional regulator ompR2 - - - - - - - - - - - Response_reg,Trans_reg_C k59_852557_1 296591.Bpro_3274 4.3e-88 277.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,2VH5K@28216|Betaproteobacteria,4AB2G@80864|Comamonadaceae 28216|Betaproteobacteria KLT protein phosphatase 2C domain protein prkC2 - 2.7.11.1,3.1.3.16 ko:K01090,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PP2C_2,Pkinase,TPR_16,TPR_19,TPR_8 k59_888082_3 527002.yaldo0001_36040 9.91e-08 52.4 COG0270@1|root,COG0270@2|Bacteria,1MV9D@1224|Proteobacteria,1RPD1@1236|Gammaproteobacteria,41GQ4@629|Yersinia 1236|Gammaproteobacteria L DNA methylase dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_28464_2 485918.Cpin_0363 2.05e-42 140.0 COG0236@1|root,COG0236@2|Bacteria,4NS6C@976|Bacteroidetes,1ITA3@117747|Sphingobacteriia 976|Bacteroidetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_741880_1 1183438.GKIL_2842 7.88e-55 192.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YR@1117|Cyanobacteria 1117|Cyanobacteria O TIGRFAM TIGR03032 family protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_2,TPR_8 k59_64772_1 5786.XP_003286007.1 3.64e-31 127.0 KOG3508@1|root,KOG3508@2759|Eukaryota,3XBW1@554915|Amoebozoa 554915|Amoebozoa S GTPase-activator protein for Ras-like GTPases - - - - - - - - - - - - RasGAP k59_931368_1 1000565.METUNv1_02884 6.59e-82 244.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KWBK@206389|Rhodocyclales 206389|Rhodocyclales O redox protein, regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC k59_790028_1 504472.Slin_1870 2.11e-32 118.0 COG2353@1|root,COG2353@2|Bacteria,4NNMD@976|Bacteroidetes,47P9R@768503|Cytophagia 976|Bacteroidetes S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_790028_2 1121897.AUGO01000008_gene2517 1.59e-18 83.2 COG1741@1|root,COG1741@2|Bacteria,4NGJ5@976|Bacteroidetes,1HYY2@117743|Flavobacteriia,2NSN5@237|Flavobacterium 976|Bacteroidetes S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin k59_967303_2 159087.Daro_1869 2.08e-48 165.0 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2VHTU@28216|Betaproteobacteria,2KVKV@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF808) - - - ko:K09781 - - - - ko00000 - - - DUF808 k59_718363_2 1000565.METUNv1_02310 6.12e-101 299.0 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,2KV0G@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_718363_3 1000565.METUNv1_02311 9.77e-152 451.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,2KV4W@206389|Rhodocyclales 206389|Rhodocyclales I AcyL-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974 k59_217421_1 1000565.METUNv1_04044 1.91e-147 429.0 COG2831@1|root,COG2831@2|Bacteria,1PRBP@1224|Proteobacteria,2VHDS@28216|Betaproteobacteria 28216|Betaproteobacteria U hemolysin activation secretion protein fhaC5 - - - - - - - - - - - POTRA_2,ShlB k59_254650_1 62928.azo2975 2.99e-116 349.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUHI@206389|Rhodocyclales 206389|Rhodocyclales G PQQ-like domain - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_539122_1 1000565.METUNv1_02007 6.93e-109 323.0 COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2WA5U@28216|Betaproteobacteria,2KXHH@206389|Rhodocyclales 206389|Rhodocyclales S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB k59_539122_2 1121035.AUCH01000016_gene2152 6.53e-21 91.3 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,2KVDW@206389|Rhodocyclales 206389|Rhodocyclales HL Belongs to the Nudix hydrolase family - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,TMP-TENI k59_648988_1 269796.Rru_A2763 1.02e-16 86.7 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UP6H@28211|Alphaproteobacteria,2JRF2@204441|Rhodospirillales 204441|Rhodospirillales T diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_468533_1 1000565.METUNv1_02470 3.46e-193 548.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,2KU6P@206389|Rhodocyclales 206389|Rhodocyclales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1110140_1 1000565.METUNv1_03756 2.2e-69 221.0 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2VJT7@28216|Betaproteobacteria,2KUCI@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyl transferases group 1 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_transf_4 k59_1110140_2 1000565.METUNv1_03755 7.54e-58 187.0 COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2VNEW@28216|Betaproteobacteria,2KVBP@206389|Rhodocyclales 206389|Rhodocyclales V Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_290588_1 1000565.METUNv1_01841 5.18e-148 425.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,2KVJH@206389|Rhodocyclales 206389|Rhodocyclales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_5 k59_290588_2 1000565.METUNv1_01842 1.11e-135 389.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,2KV7K@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_327538_1 1123033.ARNF01000075_gene2315 5.35e-105 313.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,3NJCI@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN746.PP_2469 Phe_tRNA-synt_N,tRNA-synt_2d k59_1003619_1 1304883.KI912532_gene3139 2.32e-86 259.0 COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria,2KVG4@206389|Rhodocyclales 206389|Rhodocyclales T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_609705_2 1000565.METUNv1_02441 3.93e-51 167.0 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,2KWT9@206389|Rhodocyclales 206389|Rhodocyclales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_609705_3 1000565.METUNv1_02442 9.79e-144 409.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,2KUWA@206389|Rhodocyclales 206389|Rhodocyclales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_506097_1 395495.Lcho_1432 2.82e-154 446.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,2VIUM@28216|Betaproteobacteria,1KK6H@119065|unclassified Burkholderiales 28216|Betaproteobacteria F This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation nifK - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_40611_1 1000565.METUNv1_01451 5.02e-31 117.0 COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,2VMCD@28216|Betaproteobacteria,2KVCZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT mch - 3.5.4.27 ko:K01499 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03464 RC01870 ko00000,ko00001,ko00002,ko01000 - - - MCH k59_40611_2 1000565.METUNv1_01452 2.41e-72 225.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2VJZS@28216|Betaproteobacteria,2KV9R@206389|Rhodocyclales 206389|Rhodocyclales HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - - - - - - - - - - RimK k59_649016_1 1000565.METUNv1_00318 5.33e-122 355.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2VI0A@28216|Betaproteobacteria,2KV75@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor switch protein fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_1039951_1 313606.M23134_01058 6.56e-12 71.2 COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,4NEJ8@976|Bacteroidetes,47N4Z@768503|Cytophagia 976|Bacteroidetes DZ Pkd domain containing protein - - - - - - - - - - - - MAM,TIG,fn3 k59_254674_1 1198452.Jab_2c23000 2.86e-121 369.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,2VKWR@28216|Betaproteobacteria,476VV@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014,ko:K16089 - - - - ko00000,ko02000 1.B.14,1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_327555_1 390235.PputW619_1151 3.51e-17 77.8 COG3133@1|root,COG3133@2|Bacteria,1RJWY@1224|Proteobacteria,1SA58@1236|Gammaproteobacteria,1YVEQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria M PFAM 17 kDa surface antigen - - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti k59_1003625_1 1538295.JY96_17675 2.44e-30 114.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VIVI@28216|Betaproteobacteria,1KJ4G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 2-hydroxy-3-oxopropionate reductase garR1 - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1003625_2 1229172.JQFA01000002_gene3527 7.46e-53 169.0 COG0599@1|root,COG0599@2|Bacteria,1GE58@1117|Cyanobacteria,1HFHE@1150|Oscillatoriales 1117|Cyanobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_468544_1 1000565.METUNv1_02617 9.66e-101 321.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria,2KVKM@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_468544_2 305700.B447_19649 1.45e-24 99.4 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria,2KVCH@206389|Rhodocyclales 206389|Rhodocyclales T Chemotaxis signal transduction protein - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_217436_1 1485544.JQKP01000014_gene1908 2.48e-37 134.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VHTZ@28216|Betaproteobacteria,44WPD@713636|Nitrosomonadales 28216|Betaproteobacteria KT LexA DNA binding domain lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_753234_3 1341695.BBOMB_1031 4.11e-99 328.0 COG3953@1|root,COG5283@1|root,COG5412@1|root,COG3953@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria,4D2S1@85004|Bifidobacteriales 201174|Actinobacteria S Transglycosylase SLT domain - - - - - - - - - - - - PhageMin_Tail,SLT k59_681767_1 1000565.METUNv1_02872 8.44e-93 284.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,2KUDF@206389|Rhodocyclales 206389|Rhodocyclales L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C k59_290616_1 1000565.METUNv1_00736 3.48e-79 246.0 COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,2VJ0W@28216|Betaproteobacteria,2KV1F@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_506114_1 614083.AWQR01000029_gene2173 1.2e-135 401.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2VH5R@28216|Betaproteobacteria,4A9TE@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM peptidase M61 domain protein - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_1003627_1 1000565.METUNv1_03053 6.72e-167 478.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,2KUA4@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DNA photolyase family phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_897276_1 1449346.JQMO01000003_gene2176 2.46e-14 76.3 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - Resolvase k59_254684_1 748247.AZKH_p0157 2.93e-106 313.0 COG0596@1|root,COG0596@2|Bacteria,1QW7Y@1224|Proteobacteria,2WI3X@28216|Betaproteobacteria 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_860716_2 1415780.JPOG01000001_gene10 2.94e-47 167.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1X3FH@135614|Xanthomonadales 135614|Xanthomonadales Q Male sterility protein - - - - - - - - - - - - NAD_binding_4,adh_short k59_469190_1 1049564.TevJSym_bn00220 2.1e-50 172.0 COG1638@1|root,COG1638@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K11688,ko:K21395 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_328561_1 1000565.METUNv1_03477 2.62e-15 71.2 2DM6D@1|root,31WQ8@2|Bacteria,1MZ7P@1224|Proteobacteria,2VUHB@28216|Betaproteobacteria,2KYYM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_539703_1 1198452.Jab_2c13230 1.07e-99 322.0 COG0745@1|root,COG0784@1|root,COG1511@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG1511@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,476IY@75682|Oxalobacteraceae 28216|Betaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg k59_897993_1 1123504.JQKD01000006_gene1566 9.17e-117 343.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,4ACTM@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Band 7 protein - - - - - - - - - - - - Band_7_1,HTH_17,SHOCT k59_826036_1 1000565.METUNv1_00744 9.04e-126 367.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,2KUEA@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_76285_1 700598.Niako_2468 7.32e-33 124.0 COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes 976|Bacteroidetes E Phospholipase - - - - - - - - - - - - Abhydrolase_2,DLH,Esterase,Peptidase_S9 k59_1078517_1 1144319.PMI16_03067 2.45e-30 109.0 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,474S9@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_1078517_2 1349767.GJA_1101 1.06e-05 46.6 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,473JT@75682|Oxalobacteraceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_860736_1 1229204.AMYY01000017_gene1298 6.07e-41 150.0 COG0582@1|root,COG0582@2|Bacteria,1NH8M@1224|Proteobacteria,2TUHG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_147013_1 640081.Dsui_2197 1.24e-80 251.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,2KVAQ@206389|Rhodocyclales 206389|Rhodocyclales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_328621_1 1000565.METUNv1_02013 1.23e-33 126.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VJ87@28216|Betaproteobacteria,2M013@206389|Rhodocyclales 206389|Rhodocyclales C Sodium:dicarboxylate symporter family - - - ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - - SDF k59_328621_2 1000565.METUNv1_03670 1.07e-136 390.0 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,2VW0N@28216|Betaproteobacteria,2KXJA@206389|Rhodocyclales 206389|Rhodocyclales S FecR protein - - - - - - - - - - - - FecR k59_4752_2 1000565.METUNv1_03757 3.72e-75 243.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VMAH@28216|Betaproteobacteria,2KUGS@206389|Rhodocyclales 206389|Rhodocyclales C Protein of unknown function (DUF3485) - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_1110623_1 439481.Aboo_0250 6.83e-14 72.8 COG1216@1|root,arCOG01383@2157|Archaea,2XUCM@28890|Euryarchaeota 28890|Euryarchaeota M PFAM Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_1110623_2 1120968.AUBX01000015_gene3640 1.16e-25 109.0 COG0438@1|root,COG0438@2|Bacteria,4NMHC@976|Bacteroidetes,47PHF@768503|Cytophagia 976|Bacteroidetes M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_5,Glyco_transf_4,Glycos_transf_1 k59_1040675_1 1286631.X805_30320 4.89e-110 330.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,1KN13@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Glucose-6-phosphate dehydrogenase, NAD binding domain zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_650190_1 1041138.KB890221_gene1044 2.32e-12 69.3 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria,4BCZF@82115|Rhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_650190_2 631454.N177_0388 1.52e-09 59.3 COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,1JQ7H@119043|Rhodobiaceae 28211|Alphaproteobacteria I PFAM Alpha beta hydrolase fold-3 domain protein - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_362452_1 762376.AXYL_04504 1.5e-92 287.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,3T23H@506|Alcaligenaceae 28216|Betaproteobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_291420_1 761193.Runsl_3317 1.02e-31 120.0 COG1304@1|root,COG1304@2|Bacteria,4NEBK@976|Bacteroidetes,47M15@768503|Cytophagia 976|Bacteroidetes C FMN-dependent dehydrogenase lldD - 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_1004384_1 1000565.METUNv1_02225 6.42e-16 80.5 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VHVG@28216|Betaproteobacteria,2KX8G@206389|Rhodocyclales 206389|Rhodocyclales M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_8 k59_650196_1 640081.Dsui_1515 1.42e-98 299.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,2KV46@206389|Rhodocyclales 206389|Rhodocyclales H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_217812_1 1123368.AUIS01000015_gene2646 3.68e-65 206.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,1RNVS@1236|Gammaproteobacteria,2NE58@225057|Acidithiobacillales 225057|Acidithiobacillales S Pirin - - - ko:K06911 - - - - ko00000 - - - Pirin k59_217812_2 395495.Lcho_0689 2.54e-20 89.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,2VJTZ@28216|Betaproteobacteria,1KIT3@119065|unclassified Burkholderiales 28216|Betaproteobacteria K transcriptional regulator allS_2 - - - - - - - - - - - HTH_1,LysR_substrate k59_860749_1 1000565.METUNv1_00584 8.66e-140 399.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,2KUAR@206389|Rhodocyclales 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5,6.2.1.9 ko:K01902,ko:K08692 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1110629_1 857087.Metme_0332 1.99e-27 113.0 COG1373@1|root,COG1373@2|Bacteria,1R4HK@1224|Proteobacteria,1SSIT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ATPase (AAA superfamily - - - - - - - - - - - - - k59_76328_1 944435.AXAJ01000012_gene2879 6e-37 139.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1K19S@119060|Burkholderiaceae 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_76328_2 1000565.METUNv1_00178 4.1e-45 149.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,2KWMG@206389|Rhodocyclales 206389|Rhodocyclales M This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_718930_1 1000565.METUNv1_02643 2.53e-75 231.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2VSF6@28216|Betaproteobacteria,2KWMP@206389|Rhodocyclales 206389|Rhodocyclales N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_291441_1 640081.Dsui_0449 5.98e-92 275.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,2KV15@206389|Rhodocyclales 206389|Rhodocyclales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_328661_1 395495.Lcho_4023 1.92e-91 273.0 COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2VJ8A@28216|Betaproteobacteria,1KK9S@119065|unclassified Burkholderiales 28216|Betaproteobacteria P TIGRFAM polar amino acid ABC transporter, inner membrane subunit gltJ - - ko:K02029,ko:K10003 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_328661_2 420662.Mpe_A0445 6.84e-48 159.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIQB@28216|Betaproteobacteria,1KK01@119065|unclassified Burkholderiales 28216|Betaproteobacteria P polar amino acid ABC transporter, inner membrane subunit gltK - - ko:K10002 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_826090_1 1000565.METUNv1_00817 2.64e-47 160.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,2KVFH@206389|Rhodocyclales 206389|Rhodocyclales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress - - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_826090_2 1000565.METUNv1_00818 1.05e-58 185.0 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2VUB7@28216|Betaproteobacteria,2KX1N@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ArsC family - - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_826090_3 1000565.METUNv1_00819 6.44e-61 192.0 295G7@1|root,2ZSTW@2|Bacteria,1P94Z@1224|Proteobacteria,2W6EJ@28216|Betaproteobacteria,2KZKA@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_860762_1 1000565.METUNv1_01937 1.14e-85 277.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KU7U@206389|Rhodocyclales 206389|Rhodocyclales M penicillin-binding protein 1A mcrA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_826091_1 1000565.METUNv1_02454 9.31e-144 426.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales 206389|Rhodocyclales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1004418_1 1000565.METUNv1_02358 1.75e-158 452.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,2KUQD@206389|Rhodocyclales 206389|Rhodocyclales P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_4785_1 1005048.CFU_3350 5.32e-90 283.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,472HQ@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_826093_1 1000565.METUNv1_03178 2.5e-26 100.0 2EBEM@1|root,335F7@2|Bacteria,1N431@1224|Proteobacteria,2VXHJ@28216|Betaproteobacteria,2KWYN@206389|Rhodocyclales 206389|Rhodocyclales S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - - k59_826093_2 1000565.METUNv1_03179 4.83e-189 534.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,2KUVP@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_328681_1 1000565.METUNv1_03842 6.08e-203 588.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales 206389|Rhodocyclales H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_834902_1 296591.Bpro_1599 2.64e-15 74.3 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,4AA0K@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the argininosuccinate synthase family. Type 2 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_834902_2 358220.C380_13795 2.18e-61 189.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,2VSCI@28216|Betaproteobacteria,4AEFW@80864|Comamonadaceae 28216|Betaproteobacteria S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_834902_3 365046.Rta_10620 2.83e-15 73.2 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,4ADI8@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE1 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_49464_2 485918.Cpin_5720 5.41e-46 149.0 2C82G@1|root,32RK9@2|Bacteria,4NSXV@976|Bacteroidetes,1IYD5@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_906038_1 1097668.BYI23_A014260 1.23e-43 160.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,1K6DP@119060|Burkholderiaceae 28216|Betaproteobacteria T Chase2 domain cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_199516_2 700598.Niako_5100 1.49e-61 194.0 COG2197@1|root,COG2197@2|Bacteria,4NKAD@976|Bacteroidetes,1IT3A@117747|Sphingobacteriia 976|Bacteroidetes K Two component transcriptional regulator, LuxR family - - - - - - - - - - - - GerE,Response_reg k59_342107_2 748280.NH8B_1642 4.8e-34 119.0 COG3423@1|root,COG3423@2|Bacteria,1N8W7@1224|Proteobacteria,2VWRT@28216|Betaproteobacteria,2KRV8@206351|Neisseriales 206351|Neisseriales K Winged helix-turn-helix DNA-binding - - - ko:K07724 - - - - ko00000,ko03000 - - - HTH_35 k59_300767_1 1131812.JQMS01000001_gene2769 2.68e-18 85.5 COG2271@1|root,COG2271@2|Bacteria,4NG3R@976|Bacteroidetes,1HXTV@117743|Flavobacteriia,2P0VH@237|Flavobacterium 976|Bacteroidetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like k59_300767_2 1121333.JMLH01000057_gene1707 1.99e-11 65.9 COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,3VPWG@526524|Erysipelotrichia 526524|Erysipelotrichia J Responsible for synthesis of pseudouridine from uracil - - - - - - - - - - - - PseudoU_synth_2,S4 k59_581823_1 1234364.AMSF01000027_gene3454 4.8e-37 143.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XA1E@135614|Xanthomonadales 135614|Xanthomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_342138_1 391598.FBBAL38_02250 1.07e-28 115.0 COG0642@1|root,COG3287@1|root,COG3829@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3287@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,4NGTB@976|Bacteroidetes,1HX3X@117743|Flavobacteriia 976|Bacteroidetes T FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_372039_1 883126.HMPREF9710_01379 7.76e-24 92.8 COG3668@1|root,COG3668@2|Bacteria,1N9C2@1224|Proteobacteria,2VWK0@28216|Betaproteobacteria 28216|Betaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_520909_1 83406.HDN1F_04190 2.08e-97 294.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alkane 1-monooxygenase - - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase,Rubredoxin k59_119791_2 1279009.ADICEAN_00545 1.81e-19 95.5 28ICP@1|root,2Z8EZ@2|Bacteria,4NKKI@976|Bacteroidetes,47N2N@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_520913_1 522306.CAP2UW1_3107 7.6e-12 64.3 COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2VHJN@28216|Betaproteobacteria 28216|Betaproteobacteria C L-Lactate permease glcA - - ko:K00427,ko:K03303 - - - - ko00000,ko02000 2.A.14,2.A.14.1.1 - - Lactate_perm k59_520913_2 1304883.KI912532_gene2587 5.37e-71 237.0 COG0247@1|root,COG0277@1|root,COG1145@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1145@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,2KVGQ@206389|Rhodocyclales 206389|Rhodocyclales C FAD linked oxidases, C-terminal domain - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7 k59_1048669_1 640081.Dsui_1573 6.78e-80 243.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,2KVV2@206389|Rhodocyclales 206389|Rhodocyclales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_834956_2 755732.Fluta_2686 8.47e-74 224.0 COG1607@1|root,COG1607@2|Bacteria,4PK4Y@976|Bacteroidetes,1IGGE@117743|Flavobacteriia,2PBZ1@246874|Cryomorphaceae 976|Bacteroidetes I Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1117913_1 543728.Vapar_5965 2.8e-166 479.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,4ABU5@80864|Comamonadaceae 28216|Betaproteobacteria EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_726971_1 1224318.DT73_11365 6.11e-50 163.0 COG1943@1|root,COG1943@2|Bacteria,1RAP9@1224|Proteobacteria,1S230@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_1048700_1 862908.BMS_2944 1.21e-114 340.0 COG0423@1|root,COG0423@2|Bacteria,1R3VX@1224|Proteobacteria,42MHG@68525|delta/epsilon subdivisions,2MSTT@213481|Bdellovibrionales,2WKJC@28221|Deltaproteobacteria 213481|Bdellovibrionales J Belongs to the class-II aminoacyl-tRNA synthetase family glyQS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_689877_1 402626.Rpic_4819 2.64e-37 128.0 2BZ0G@1|root,32R44@2|Bacteria,1RI37@1224|Proteobacteria,2VT46@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_547675_1 351348.Maqu_2158 7.4e-13 68.6 COG2227@1|root,COG2227@2|Bacteria,1R9ZR@1224|Proteobacteria,1S27B@1236|Gammaproteobacteria,4672C@72275|Alteromonadaceae 1236|Gammaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_547675_2 1201290.M902_2002 2.41e-31 112.0 COG1393@1|root,COG1393@2|Bacteria,1PPAE@1224|Proteobacteria,42SIG@68525|delta/epsilon subdivisions,2MUS8@213481|Bdellovibrionales,2X5QB@28221|Deltaproteobacteria 213481|Bdellovibrionales P ArsC family - - - - - - - - - - - - ArsC k59_13148_1 62928.azo2869 4.57e-81 244.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,2KWAK@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome B561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_726983_1 1000565.METUNv1_01249 4.26e-112 330.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2VIUC@28216|Betaproteobacteria,2KZZ7@206389|Rhodocyclales 206389|Rhodocyclales C Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_49529_1 1562701.BBOF01000044_gene1258 1.85e-28 111.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2VNV4@28216|Betaproteobacteria,1K7AD@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM RecT protein recT - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_49529_2 587753.EY04_17415 1.15e-92 277.0 2DIG9@1|root,3036R@2|Bacteria,1RBPA@1224|Proteobacteria 1224|Proteobacteria L YqaJ-like viral recombinase domain - - 3.1.11.3 ko:K01143 - - - - ko00000,ko01000 - - - YqaJ k59_869683_1 1096769.Pelub83DRAFT_0078 7.09e-15 76.6 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,4BPKB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_477766_1 1502770.JQMG01000001_gene2221 3.8e-24 104.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,2KMDJ@206350|Nitrosomonadales 206350|Nitrosomonadales O Glycosyltransferase like family - - - - - - - - - - - - Glyco_tranf_2_5,Glyco_transf_41,Methyltransf_12,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_342229_1 232721.Ajs_0348 1.36e-68 223.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,4A9UF@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_581876_1 1097668.BYI23_E001910 0.000411 41.6 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria,1K6ZE@119060|Burkholderiaceae 28216|Betaproteobacteria T Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_581876_2 187272.Mlg_2675 1.48e-15 79.3 COG2905@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X0A7@135613|Chromatiales 135613|Chromatiales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_9 k59_49546_1 1000565.METUNv1_02541 2.54e-91 278.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,2KV7H@206389|Rhodocyclales 206389|Rhodocyclales I Desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_727004_3 13690.CP98_03708 2.54e-42 155.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2U82T@28211|Alphaproteobacteria 28211|Alphaproteobacteria L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_547713_1 62928.azo2110 1.71e-24 104.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,2KUDH@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_119851_1 1122951.ATUE01000006_gene1008 1.4e-137 395.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,3NIJP@468|Moraxellaceae 1236|Gammaproteobacteria O Belongs to the peptidase M48B family htpX GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_450125_2 420662.Mpe_A2807 1.42e-06 48.9 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VKE2@28216|Betaproteobacteria,1KJP6@119065|unclassified Burkholderiales 28216|Betaproteobacteria C PFAM NADH ubiquinone oxidoreductase, 20 hoxB - 1.12.7.2,1.12.99.6 ko:K00534,ko:K06282 ko00633,ko01120,map00633,map01120 - R00019,R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_548992_2 1000565.METUNv1_03283 8.59e-28 112.0 COG0664@1|root,COG2172@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,2KX5A@206389|Rhodocyclales 206389|Rhodocyclales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_50616_1 83406.HDN1F_18670 1.78e-66 220.0 COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1J5C7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iECDH10B_1368.ECDH10B_2448,iECDH1ME8569_1439.ECDH1ME8569_2223,iETEC_1333.ETEC_2421,iEcDH1_1363.EcDH1_1371,iPC815.YPO2553,iUMNK88_1353.UMNK88_2836 Complex1_30kDa,Complex1_49kDa k59_582813_1 1122605.KB893645_gene948 1.92e-63 213.0 COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,1IPRQ@117747|Sphingobacteriia 976|Bacteroidetes S glycosyl hydrolase of - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 k59_617013_1 1500894.JQNN01000001_gene4361 3.85e-90 272.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,473M7@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Pilus retraction pilT - - ko:K02669,ko:K12203 - - - - ko00000,ko02035,ko02044 3.A.15.2,3.A.7.10.1,3.A.7.9.1 - - T2SSE k59_1050785_1 558152.IQ37_03975 2.43e-09 62.0 COG3279@1|root,COG3279@2|Bacteria,4NPFH@976|Bacteroidetes,1IIMX@117743|Flavobacteriia,3ZQ58@59732|Chryseobacterium 976|Bacteroidetes KT LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_451963_1 1265310.CCBD010000024_gene1819 5.01e-42 149.0 COG0753@1|root,COG0753@2|Bacteria,2GN9F@201174|Actinobacteria,232HC@1762|Mycobacteriaceae 201174|Actinobacteria P Has an organic peroxide-dependent peroxidase activity - GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005506,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017144,GO:0019222,GO:0020037,GO:0031323,GO:0042221,GO:0042743,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051716,GO:0055114,GO:0065007,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748,GO:2000377 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase,Catalase-rel k59_582828_1 688245.CtCNB1_2966 1.34e-43 147.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,4ADFM@80864|Comamonadaceae 28216|Betaproteobacteria D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_582828_2 1268622.AVS7_02951 4.06e-83 247.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,4AE0C@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Methionine sulfoxide reductase B msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_225251_1 85643.Tmz1t_3601 8.03e-280 795.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,2VJSS@28216|Betaproteobacteria,2KWGA@206389|Rhodocyclales 206389|Rhodocyclales L EcoEI R protein C-terminal hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF4145,EcoEI_R_C,HSDR_N,Helicase_C,ResIII k59_582832_1 1123354.AUDR01000013_gene513 9.58e-60 191.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,1KRY2@119069|Hydrogenophilales 119069|Hydrogenophilales S CbbQ/NirQ/NorQ C-terminal - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_522976_2 553217.ENHAE0001_2219 5.67e-21 100.0 2DTWD@1|root,33MYR@2|Bacteria,1NQDX@1224|Proteobacteria,1SRJZ@1236|Gammaproteobacteria,3NQ7K@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_582845_1 316058.RPB_1067 1.83e-35 134.0 2E7PV@1|root,3325E@2|Bacteria,1NERV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1014268_1 1003200.AXXA_27955 3.9e-39 153.0 2DBPZ@1|root,2ZABJ@2|Bacteria,1R7CU@1224|Proteobacteria,2VZBA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1014270_1 1030157.AFMP01000057_gene786 2.84e-51 189.0 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2K7ED@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_801241_1 159087.Daro_4035 1.44e-58 191.0 COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2VNS7@28216|Betaproteobacteria,2KV4Q@206389|Rhodocyclales 206389|Rhodocyclales S import inner membrane translocase subunit Tim44 - - - - - - - - - - - - Tim44 k59_225282_1 883126.HMPREF9710_03287 8.41e-06 47.8 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,4724E@75682|Oxalobacteraceae 28216|Betaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_836053_1 1122951.ATUE01000005_gene1822 4.02e-75 228.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,3NJZR@468|Moraxellaceae 1236|Gammaproteobacteria J Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_1014276_1 1144342.PMI40_04185 2.38e-67 211.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,472DI@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,ACT_6,Formyl_trans_N k59_265475_1 1000565.METUNv1_00086 1.03e-87 265.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2VK1G@28216|Betaproteobacteria,2KW3H@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_265475_2 663932.KB902575_gene2355 5.16e-21 96.7 COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,2JS3Q@204441|Rhodospirillales 204441|Rhodospirillales H Biotin/lipoate A/B protein ligase family birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,BPL_LplA_LipB_2 k59_479132_1 522306.CAP2UW1_3823 2.23e-30 110.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2VSK1@28216|Betaproteobacteria,1KQX0@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria N Flagella basal body rod protein flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_479132_2 1502852.FG94_02583 1.27e-43 149.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2VSF6@28216|Betaproteobacteria,474BB@75682|Oxalobacteraceae 28216|Betaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_617074_2 1000565.METUNv1_03416 3.43e-35 136.0 COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_549091_2 375286.mma_2466 1.33e-08 61.2 COG3064@1|root,COG3064@2|Bacteria,1RKZU@1224|Proteobacteria,2WGP5@28216|Betaproteobacteria,4792F@75682|Oxalobacteraceae 28216|Betaproteobacteria M TonB C terminal tolA - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - TonB_2 k59_344263_1 1000565.METUNv1_01035 7.22e-133 393.0 COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,2KVRC@206389|Rhodocyclales 28216|Betaproteobacteria H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_344266_1 663610.JQKO01000004_gene2838 4.51e-88 270.0 COG1408@1|root,COG1408@2|Bacteria,1QW5K@1224|Proteobacteria,2U6XC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metallophosphoesterase - - - - - - - - - - - - Metallophos k59_452091_2 236097.ADG881_2645 6.14e-57 197.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis protein histidine kinase and related chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_761796_1 522306.CAP2UW1_4298 9.94e-58 189.0 COG0726@1|root,COG0726@2|Bacteria,1RG9W@1224|Proteobacteria,2VRGD@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_666506_2 1121920.AUAU01000006_gene360 8.64e-55 181.0 COG1191@1|root,COG1191@2|Bacteria,3Y4Q5@57723|Acidobacteria 57723|Acidobacteria K TIGRFAM RNA polymerase sigma factor, FliA WhiG family - - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_201588_1 614083.AWQR01000031_gene2608 5.32e-119 341.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VH4A@28216|Betaproteobacteria,4AAGC@80864|Comamonadaceae 28216|Betaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_1014325_2 292415.Tbd_1628 6.71e-38 144.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,1KRD4@119069|Hydrogenophilales 119069|Hydrogenophilales N Flagellar basal body rod FlgEFG protein C-terminal - - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_317145_1 614083.AWQR01000031_gene2664 1.65e-91 284.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,4AB5U@80864|Comamonadaceae 28216|Betaproteobacteria T SMART Nucleotide binding protein, PINc phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_738726_1 9986.ENSOCUP00000003671 1.15e-70 229.0 COG0124@1|root,KOG1936@2759|Eukaryota,38DB2@33154|Opisthokonta,3BBCC@33208|Metazoa,3CU64@33213|Bilateria,48A04@7711|Chordata,4926C@7742|Vertebrata,3JEBW@40674|Mammalia,35P69@314146|Euarchontoglires 33208|Metazoa J Histidine--tRNA ligase, cytoplasmic HARS GO:0000003,GO:0000122,GO:0002119,GO:0002164,GO:0003006,GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006357,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0007275,GO:0007276,GO:0007281,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009791,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032501,GO:0032502,GO:0032504,GO:0032543,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0045892,GO:0045934,GO:0046483,GO:0046983,GO:0048468,GO:0048519,GO:0048523,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140053,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,WHEP-TRS,tRNA-synt_His k59_849368_1 290315.Clim_1665 2.04e-33 132.0 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.4.21.10 ko:K01317 - - - - ko00000,ko01000,ko01002,ko04131 - - - DUF11,FG-GAP,HemolysinCabind,VWA,VWA_2 k59_988256_1 1123504.JQKD01000008_gene5448 3.16e-45 150.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,4A9SQ@80864|Comamonadaceae 28216|Betaproteobacteria EH TIGRFAM glutamine amidotransferase of anthranilate synthase trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_988256_2 365044.Pnap_3650 6.12e-48 163.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,4AAY4@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_812351_1 1519464.HY22_01200 1.81e-73 241.0 COG2366@1|root,COG2366@2|Bacteria 2|Bacteria D antibiotic biosynthetic process - - 3.5.1.97 ko:K07116 - - - - ko00000,ko01000 - - - Penicil_amidase k59_317154_1 1123020.AUIE01000007_gene3279 4.59e-64 206.0 COG0175@1|root,COG0175@2|Bacteria,1QEGX@1224|Proteobacteria,1TB6M@1236|Gammaproteobacteria,1YH1B@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_917542_1 338969.Rfer_3716 8.62e-85 256.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2VSF6@28216|Betaproteobacteria,4AEAR@80864|Comamonadaceae 28216|Betaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_917542_2 338969.Rfer_3717 8.28e-44 154.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,4AATG@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar basal body rod protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_593017_1 1000565.METUNv1_03023 1.3e-94 297.0 COG4389@1|root,COG4389@2|Bacteria,1MWEH@1224|Proteobacteria,2VIZV@28216|Betaproteobacteria,2KUTK@206389|Rhodocyclales 206389|Rhodocyclales L Site-specific recombinase - - - - - - - - - - - - SpecificRecomb k59_278009_1 1175306.GWL_03770 5.33e-107 316.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,475T3@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1069181_1 595537.Varpa_1201 1.35e-08 54.7 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,4A9QT@80864|Comamonadaceae 28216|Betaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1069181_2 595537.Varpa_1202 8.92e-57 177.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,4AECC@80864|Comamonadaceae 28216|Betaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_771756_1 1223521.BBJX01000004_gene2265 1.13e-59 191.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2VIR5@28216|Betaproteobacteria,4A9SI@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_771756_2 358220.C380_07730 2.76e-73 230.0 COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,4AB9R@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_317182_1 396588.Tgr7_0399 2.38e-74 232.0 28H88@1|root,2Z7K7@2|Bacteria,1R5AY@1224|Proteobacteria,1RZB1@1236|Gammaproteobacteria,1X0X1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - Phage_cap_E k59_317182_3 28229.ND2E_1010 1.67e-27 104.0 COG4387@1|root,COG4387@2|Bacteria,1N1K0@1224|Proteobacteria,1S9W3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage protein GP36 - - - - - - - - - - - - DUF1320 k59_988286_1 1120792.JAFV01000001_gene696 4.72e-65 219.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,36XKH@31993|Methylocystaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_493016_1 338969.Rfer_2114 3.84e-89 273.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,4ABSU@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM permease YjgP YjgQ family protein lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1069220_1 381666.H16_A0191 4.15e-41 155.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2VHP6@28216|Betaproteobacteria,1KIJD@119060|Burkholderiaceae 28216|Betaproteobacteria H TonB dependent receptor phuR - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_884054_1 1279009.ADICEAN_03871 3.07e-62 214.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes,47KFY@768503|Cytophagia 976|Bacteroidetes C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit bfmBA - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_562966_1 365044.Pnap_0699 9.9e-35 124.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,4AA2J@80864|Comamonadaceae 28216|Betaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_562966_2 296591.Bpro_0808 2.24e-141 401.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,4ABUC@80864|Comamonadaceae 28216|Betaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_702928_1 1437882.AZRU01000008_gene2970 1.06e-59 189.0 COG3179@1|root,COG3179@2|Bacteria 2|Bacteria Q chitinase chiIII - - ko:K03791 - - - - ko00000 - GH19 - Glyco_hydro_19 k59_493068_1 1002340.AFCF01000029_gene3342 4.95e-11 66.2 COG2197@1|root,COG2197@2|Bacteria,1RAAY@1224|Proteobacteria,2U69Z@28211|Alphaproteobacteria,34DSP@302485|Phaeobacter 28211|Alphaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS,PAS_3,PAS_9 k59_317247_1 1122921.KB898195_gene946 5.39e-41 146.0 COG1175@1|root,COG1175@2|Bacteria,1U7MW@1239|Firmicutes,4IQNB@91061|Bacilli,26UH8@186822|Paenibacillaceae 91061|Bacilli G Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k59_169380_1 930169.B5T_00975 6.28e-108 329.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1XHUX@135619|Oceanospirillales 135619|Oceanospirillales T PrkA family serine protein kinase prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_884094_1 1353531.AZNX01000001_gene1902 2.36e-17 81.3 COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TRAM@28211|Alphaproteobacteria,4B8B6@82115|Rhizobiaceae 28211|Alphaproteobacteria H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_884094_2 744980.TRICHSKD4_5229 4.04e-53 183.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family stcD - - ko:K21833 - - - - ko00000 - - - NAD_binding_8,Oxidored_FMN,Pyr_redox_2 k59_988343_1 614083.AWQR01000031_gene2657 5.12e-114 348.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4AA18@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_738813_1 760192.Halhy_0449 1.89e-80 252.0 COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,1IVDJ@117747|Sphingobacteriia 976|Bacteroidetes M glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 k59_771800_1 1232683.ADIMK_1262 2.32e-117 367.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465AJ@72275|Alteromonadaceae 1236|Gammaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - CHASE,EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_771800_2 640081.Dsui_1776 1.07e-08 55.1 COG5581@1|root,COG5581@2|Bacteria,1RBFR@1224|Proteobacteria,2VQWE@28216|Betaproteobacteria,2M037@206389|Rhodocyclales 206389|Rhodocyclales M Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - - - - - - - - - - PilZ,YcgR k59_62270_1 1177154.Y5S_02992 3.29e-44 154.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1S0CW@1236|Gammaproteobacteria,1XJD8@135619|Oceanospirillales 135619|Oceanospirillales NT COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain - - - ko:K06597 ko02020,map02020 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheB_methylest k59_98235_1 768671.ThimaDRAFT_1159 1.02e-71 228.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1WXI6@135613|Chromatiales 135613|Chromatiales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_317278_1 1123257.AUFV01000001_gene1885 1.96e-11 65.1 COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein acetylation - - - - - - - - - - - - - k59_317278_2 62977.ACIAD1933 2.65e-07 55.1 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,3NKNX@468|Moraxellaceae 1236|Gammaproteobacteria S A domain family that is part of the cupin metalloenzyme superfamily. ycfD GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_389005_1 204773.HEAR3118 3.96e-95 290.0 COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2VH0G@28216|Betaproteobacteria,473SK@75682|Oxalobacteraceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_2 k59_235306_1 365046.Rta_08590 4.45e-42 150.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,4A9QN@80864|Comamonadaceae 28216|Betaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_593106_1 1121481.AUAS01000007_gene945 2.24e-38 143.0 COG1413@1|root,COG2010@1|root,COG2133@1|root,COG2755@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,4NEQA@976|Bacteroidetes,47MTS@768503|Cytophagia 976|Bacteroidetes C HEAT repeats - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3,HEAT_2,Lipase_GDSL_2 k59_1027102_1 649349.Lbys_0592 2.71e-87 281.0 COG0495@1|root,COG0495@2|Bacteria,4NE5K@976|Bacteroidetes,47MI0@768503|Cytophagia 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,DUF559,tRNA-synt_1,tRNA-synt_1_2 k59_133406_1 202955.BBND01000017_gene1596 0.000142 44.7 28KZ1@1|root,2ZAED@2|Bacteria,1QWYQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_133406_2 911239.CF149_22928 7.33e-49 165.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,1S8Y0@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_98267_1 1000565.METUNv1_02336 6.1e-54 187.0 COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,2VK1M@28216|Betaproteobacteria,2KUAQ@206389|Rhodocyclales 206389|Rhodocyclales S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - VWA_CoxE k59_812457_1 1177154.Y5S_00298 3.4e-46 161.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XQZT@135619|Oceanospirillales 135619|Oceanospirillales PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_563035_1 1000565.METUNv1_01170 2.8e-81 244.0 COG0664@1|root,COG0664@2|Bacteria,1N4C9@1224|Proteobacteria,2VVJC@28216|Betaproteobacteria,2KX36@206389|Rhodocyclales 206389|Rhodocyclales T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_563035_2 1000565.METUNv1_01169 1.65e-62 206.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales 206389|Rhodocyclales G BT1 family - - - - - - - - - - - - BT1 k59_988405_1 614083.AWQR01000010_gene1613 1.6e-113 342.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,4ABP4@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM phosphoesterase, RecJ domain protein recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_703010_1 1458427.BAWN01000015_gene963 1.64e-31 115.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,4AEEQ@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM thioesterase superfamily protein ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_703010_2 614083.AWQR01000019_gene3788 6.83e-28 111.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,4AAIV@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM aminotransferase, class I and II aspC - - - - - - - - - - - Aminotran_1_2 k59_950144_1 1268622.AVS7_03752 0.000741 42.7 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,4AAFY@80864|Comamonadaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_917679_1 1348114.OM33_08095 2.43e-58 203.0 COG0584@1|root,COG0737@1|root,COG0584@2|Bacteria,COG0737@2|Bacteria,1NTU5@1224|Proteobacteria,1RR0F@1236|Gammaproteobacteria,2Q04P@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria CF Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_771857_1 925409.KI911562_gene1108 1.05e-98 302.0 COG0138@1|root,COG0138@2|Bacteria,4NEZD@976|Bacteroidetes,1IP42@117747|Sphingobacteriia 976|Bacteroidetes F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_919020_1 204773.HEAR2743 2.13e-36 142.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,473JA@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_851321_1 1294142.CINTURNW_2571 4.1e-07 52.8 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,36EFN@31979|Clostridiaceae 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_851321_2 883126.HMPREF9710_05044 9.86e-23 95.9 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2VJE8@28216|Betaproteobacteria,47355@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family ydfG - 1.1.1.276,1.1.1.381 ko:K05886,ko:K16066 ko00240,ko00260,ko01100,map00240,map00260,map01100 - R09289,R10851,R10852 RC00087,RC00525,RC03288 ko00000,ko00001,ko01000 - - - adh_short k59_886670_1 543728.Vapar_2544 8.27e-36 129.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,4ABTB@80864|Comamonadaceae 28216|Betaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_886670_2 614083.AWQR01000018_gene1871 4.06e-31 121.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9,SBP_bac_3 k59_851322_1 713587.THITH_12390 7.55e-25 110.0 COG3614@1|root,COG5001@1|root,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,HAMP,MASE1,PAS_9 k59_171060_2 1000565.METUNv1_00078 1.07e-161 454.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,2KV21@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_171060_3 864051.BurJ1DRAFT_0510 3.81e-32 117.0 29A26@1|root,2ZX3K@2|Bacteria,1RFE8@1224|Proteobacteria,2VRJJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_391334_1 1198452.Jab_2c26170 1.53e-104 313.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria 28216|Betaproteobacteria T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814 - - - - ko00000,ko02022 - - - DUF3369,HD,HD_5,Response_reg k59_951315_1 292415.Tbd_0182 1.42e-22 90.9 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,1KS8I@119069|Hydrogenophilales 119069|Hydrogenophilales I Biotin-requiring enzyme - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_951315_2 1177179.A11A3_16495 2.77e-82 256.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1XI4J@135619|Oceanospirillales 135619|Oceanospirillales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_279785_1 1327941.T1S9Y0_9CAUD 6.13e-44 167.0 4QH94@10239|Viruses,4QWKQ@35237|dsDNA viruses no RNA stage,4QSAS@28883|Caudovirales,4QNT6@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_740529_1 382464.ABSI01000010_gene3794 7.89e-14 76.6 COG4888@1|root,COG4888@2|Bacteria,46UDG@74201|Verrucomicrobia 2|Bacteria O PFAM ASPIC UnbV domain protein - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_813704_1 1380387.JADM01000007_gene657 3.02e-71 238.0 COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XIAY@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase gacS - 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_466768_1 1000565.METUNv1_03163 9.07e-164 472.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,2KVA8@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_288603_2 1000565.METUNv1_03544 6.68e-120 344.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,2KW2M@206389|Rhodocyclales 206389|Rhodocyclales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_288603_4 1000565.METUNv1_03543 3.6e-104 303.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2VQ3U@28216|Betaproteobacteria,2KW42@206389|Rhodocyclales 206389|Rhodocyclales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_288603_5 1000565.METUNv1_03542 1.58e-98 302.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,2KUBD@206389|Rhodocyclales 206389|Rhodocyclales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_38739_1 1122951.ATUE01000005_gene1864 5.66e-115 333.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,3NK7V@468|Moraxellaceae 1236|Gammaproteobacteria E imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_109590_1 227377.CBU_0704 1.57e-52 175.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,1RN2T@1236|Gammaproteobacteria,1JEEN@118969|Legionellales 118969|Legionellales GM ABC transporter - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran k59_466771_2 159087.Daro_3350 9.7e-24 100.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - CHASE8,HATPase_c,HisKA,Hpt,Response_reg k59_1038103_1 981223.AIED01000039_gene535 1.63e-27 109.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,3NJGF@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1038103_2 395961.Cyan7425_4181 1.35e-11 65.5 COG1194@1|root,COG1194@2|Bacteria,1G7MC@1117|Cyanobacteria,3KH3E@43988|Cyanothece 1117|Cyanobacteria L A G-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_38747_1 1000565.METUNv1_01848 1.33e-44 155.0 COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria 28216|Betaproteobacteria S short chain amide porin - - - - - - - - - - - - - k59_38747_2 1000565.METUNv1_01849 1.33e-23 95.9 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2VHU3@28216|Betaproteobacteria,2KUX6@206389|Rhodocyclales 206389|Rhodocyclales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 k59_360054_2 1538295.JY96_04050 2.57e-86 268.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,1KK0V@119065|unclassified Burkholderiales 28216|Betaproteobacteria C NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_716962_1 640081.Dsui_2689 4.83e-74 232.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,2KW5H@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_716962_2 1454004.AW11_01611 1.65e-48 167.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,1KPSC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_966067_1 1123393.KB891316_gene1092 4.47e-84 261.0 COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2W93M@28216|Betaproteobacteria,1KSBI@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1 k59_182200_1 347834.RHE_CH01097 1.46e-32 122.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria,4B747@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_182200_4 216596.RL3937 5.46e-96 316.0 COG2268@1|root,COG2268@2|Bacteria,1NT13@1224|Proteobacteria,2U335@28211|Alphaproteobacteria,4BCZZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Band 7 protein - - - - - - - - - - - - - k59_145263_1 1211114.ALIP01000167_gene457 3.05e-39 142.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1X491@135614|Xanthomonadales 135614|Xanthomonadales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_145263_2 497321.C664_19576 4.02e-13 66.2 COG1426@1|root,COG1426@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_751968_1 1000565.METUNv1_02136 8.93e-117 341.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,2KUA8@206389|Rhodocyclales 206389|Rhodocyclales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_432121_1 1502852.FG94_04465 7.7e-48 169.0 COG2244@1|root,COG2244@2|Bacteria,1R6ME@1224|Proteobacteria,2VNGZ@28216|Betaproteobacteria,4753X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Polysaccharide biosynthesis protein rfbE - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_1074797_2 667121.ET1_03_00980 4.17e-25 105.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_858920_1 1268622.AVS7_02574 1.6e-103 306.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,4AASJ@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_537703_1 375286.mma_0537 1.33e-36 134.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,472QU@75682|Oxalobacteraceae 28216|Betaproteobacteria J Ribonuclease E/G family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_325124_1 1000565.METUNv1_02666 7.41e-159 448.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,2KUCF@206389|Rhodocyclales 206389|Rhodocyclales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_930155_1 397945.Aave_2365 1.12e-62 203.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,4AJKY@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_823495_1 640081.Dsui_0035 2.71e-32 126.0 COG0666@1|root,COG0666@2|Bacteria,1R76J@1224|Proteobacteria,2VP42@28216|Betaproteobacteria,2KV0E@206389|Rhodocyclales 206389|Rhodocyclales S Ankyrin repeat - - - - - - - - - - - - Ank_4 k59_1001877_1 1306174.JODP01000006_gene3229 1.48e-65 220.0 COG4695@1|root,COG4695@2|Bacteria,2IE2H@201174|Actinobacteria 201174|Actinobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_1001878_1 340.xcc-b100_1161 6.21e-32 124.0 COG0380@1|root,COG0561@1|root,COG0380@2|Bacteria,COG0561@2|Bacteria,1MUIY@1224|Proteobacteria,1RNG7@1236|Gammaproteobacteria,1X4MB@135614|Xanthomonadales 135614|Xanthomonadales G Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor - - - - - - - - - - - - Glyco_transf_20,S6PP k59_1074817_1 1000565.METUNv1_03999 5.84e-68 213.0 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,2KX0U@206389|Rhodocyclales 206389|Rhodocyclales H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_1074817_2 1000565.METUNv1_04000 2.02e-139 400.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2VQ46@28216|Betaproteobacteria,2KWPX@206389|Rhodocyclales 206389|Rhodocyclales M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_1074817_3 1000565.METUNv1_04001 1.26e-14 70.1 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,2KW5B@206389|Rhodocyclales 206389|Rhodocyclales S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_325141_1 1000565.METUNv1_01664 3.08e-100 298.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2VI50@28216|Betaproteobacteria,2KU6X@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rmlD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_360084_1 713586.KB900536_gene1487 5.65e-25 101.0 2DZRC@1|root,32VGV@2|Bacteria,1N2PT@1224|Proteobacteria,1SQQ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Cytochrom_C_2 k59_966082_1 1249627.D779_2452 1.53e-42 160.0 COG0840@1|root,COG0840@2|Bacteria,1NCMF@1224|Proteobacteria,1RRP8@1236|Gammaproteobacteria,1WXEU@135613|Chromatiales 135613|Chromatiales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_966082_2 264730.PSPPH_0807 2.01e-65 201.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,1Z7IR@136849|Pseudomonas syringae group 1236|Gammaproteobacteria T Chemotaxis protein CheY IV02_18015 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_966082_3 1448139.AI20_14115 7.73e-19 82.0 COG1366@1|root,COG1366@2|Bacteria,1N8B6@1224|Proteobacteria,1SDVH@1236|Gammaproteobacteria,1Y65X@135624|Aeromonadales 135624|Aeromonadales T STAS domain - - - - - - - - - - - - STAS_2 k59_966082_4 697282.Mettu_2767 4.2e-22 95.9 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases cheA3 - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_573345_1 1121035.AUCH01000027_gene3395 2.71e-80 253.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,2KVDJ@206389|Rhodocyclales 206389|Rhodocyclales M HlyD membrane-fusion protein of T1SS - - - ko:K12537,ko:K16300 - M00328,M00571 - - ko00000,ko00002,ko02000,ko02044 8.A.1,8.A.1.3.3 - - HlyD,HlyD_3 k59_325145_1 1000565.METUNv1_00464 9.52e-117 349.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KUWX@206389|Rhodocyclales 206389|Rhodocyclales I Poly(R)-hydroxyalkanoic acid synthase, class I - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_1038153_1 76114.ebA29 2.74e-24 103.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,2KV9M@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_823509_1 1000565.METUNv1_03029 3.63e-85 268.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUI4@206389|Rhodocyclales 206389|Rhodocyclales P COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_288663_1 1000565.METUNv1_00130 1.28e-57 184.0 COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,2VW9Q@28216|Betaproteobacteria,2KXB4@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 k59_288663_3 1000565.METUNv1_00132 8.11e-112 328.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,2KU6A@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_1002927_1 1000565.METUNv1_01364 5.21e-96 307.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KURD@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07239 - - - - ko00000 2.A.6.1 - - ACR_tran k59_1076318_2 1115515.EV102420_06_00350 6.16e-41 146.0 2AXQF@1|root,31PR8@2|Bacteria,1RKX8@1224|Proteobacteria,1S6JS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1076318_3 194699.Q775C5_BPBPP 1.2e-23 93.2 4QHDG@10239|Viruses,4QYUZ@35237|dsDNA viruses no RNA stage,4QRSG@28883|Caudovirales,4QNP1@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_433652_1 522306.CAP2UW1_0693 4.57e-40 142.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,1KQQ0@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_433652_2 640081.Dsui_0890 2.52e-25 98.2 COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,2KW9X@206389|Rhodocyclales 206389|Rhodocyclales M shape-determining protein mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_146040_1 1120948.KB903229_gene5290 4.66e-47 163.0 COG1075@1|root,COG1075@2|Bacteria,2IDMQ@201174|Actinobacteria,4E1N1@85010|Pseudonocardiales 201174|Actinobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Lipase_2 k59_1002930_1 1175306.GWL_23850 0.000406 49.7 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VHVG@28216|Betaproteobacteria 28216|Betaproteobacteria M TPR repeat-containing protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_397008_2 1349767.GJA_2700 2.12e-83 257.0 COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,2VHDP@28216|Betaproteobacteria,472CS@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the heat shock protein 70 family yegD - - ko:K04046 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_254030_1 1123393.KB891316_gene1546 9.68e-13 67.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2VIZ6@28216|Betaproteobacteria,1KRSC@119069|Hydrogenophilales 119069|Hydrogenophilales G HAD-hyrolase-like - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_254030_2 1387312.BAUS01000004_gene1439 1.8e-35 132.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,2KKDB@206350|Nitrosomonadales 206350|Nitrosomonadales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_433679_1 1000565.METUNv1_01231 2.81e-133 383.0 COG0725@1|root,COG0725@2|Bacteria,1PT1P@1224|Proteobacteria,2VSC1@28216|Betaproteobacteria,2KYXW@206389|Rhodocyclales 206389|Rhodocyclales P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_11 k59_824587_1 1344012.ATMI01000052_gene1938 9.37e-67 221.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,1RZ7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_183731_1 1000565.METUNv1_03780 4.52e-84 280.0 COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria,2WEH7@28216|Betaproteobacteria,2KY9X@206389|Rhodocyclales 206389|Rhodocyclales S Heparinase II/III-like protein - - - - - - - - - - - - DUF4962,Hepar_II_III,VanZ k59_3585_1 385682.AFSL01000056_gene1966 4.25e-10 60.8 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,4NFJE@976|Bacteroidetes,2FM4R@200643|Bacteroidia,3XJG5@558415|Marinilabiliaceae 976|Bacteroidetes H RibD C-terminal domain ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_74653_1 1000565.METUNv1_02115 2.7e-271 782.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,2KUNX@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,Response_reg k59_74653_2 1000565.METUNv1_02114 2.31e-83 253.0 COG3540@1|root,COG3540@2|Bacteria,1NITU@1224|Proteobacteria,2W3YR@28216|Betaproteobacteria 28216|Betaproteobacteria P Laminin B (Domain IV) - - - - - - - - - - - - Laminin_B,VPEP k59_1109674_1 1000565.METUNv1_03501 3.37e-53 186.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,2KUMB@206389|Rhodocyclales 206389|Rhodocyclales P Von Willebrand factor type A - - - - - - - - - - - - VWA k59_110507_1 1304883.KI912532_gene2354 2.39e-104 319.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,2KVKE@206389|Rhodocyclales 206389|Rhodocyclales T PrkA family serine protein kinase prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_896547_1 1000565.METUNv1_02029 6.02e-77 242.0 COG1819@1|root,COG1819@2|Bacteria,1REWD@1224|Proteobacteria,2VR80@28216|Betaproteobacteria,2KYQU@206389|Rhodocyclales 206389|Rhodocyclales CG Glycosyl transferase family 1 - - - - - - - - - - - - - k59_896547_2 1000565.METUNv1_02030 1.1e-68 223.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUTR@206389|Rhodocyclales 206389|Rhodocyclales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_824596_1 1000565.METUNv1_03805 1.57e-110 335.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_326608_1 614083.AWQR01000020_gene210 8.72e-57 189.0 COG4254@1|root,COG4254@2|Bacteria,1NBPR@1224|Proteobacteria,2VWWI@28216|Betaproteobacteria,4AH9S@80864|Comamonadaceae 28216|Betaproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_361136_1 1122951.ATUE01000005_gene1522 9.84e-57 184.0 COG3028@1|root,COG3028@2|Bacteria 2|Bacteria S Belongs to the UPF0307 family yjgA - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_717920_1 1000565.METUNv1_02528 6.91e-103 325.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2VJF3@28216|Betaproteobacteria,2KW03@206389|Rhodocyclales 206389|Rhodocyclales L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_254049_2 1123248.KB893335_gene2883 2.31e-56 178.0 COG2259@1|root,33816@2|Bacteria,4NUVH@976|Bacteroidetes 976|Bacteroidetes S DoxX-like family - - - - - - - - - - - - DoxX_2 k59_859797_1 936053.I1CPS8 6.61e-56 203.0 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_183764_1 1198452.Jab_1c12430 7.14e-35 128.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,473P6@75682|Oxalobacteraceae 28216|Betaproteobacteria P Ring hydroxylating alpha subunit (catalytic domain) alcE - 1.14.15.7 ko:K00499 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1076389_1 28152.DJ57_2245 4.94e-123 380.0 28IJ1@1|root,2Z8K0@2|Bacteria,1R5PC@1224|Proteobacteria,1S1ER@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1089501_2 228410.NE2521 2.91e-19 90.1 COG0758@1|root,COG3266@1|root,COG0758@2|Bacteria,COG3266@2|Bacteria,1Q7YP@1224|Proteobacteria,2VQH2@28216|Betaproteobacteria 28216|Betaproteobacteria LU DNA recombination-mediator protein A - - - - - - - - - - - - DNA_processg_A k59_689571_1 1123393.KB891332_gene2832 8.47e-18 80.5 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VSIN@28216|Betaproteobacteria,1KRTP@119069|Hydrogenophilales 119069|Hydrogenophilales S MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_689571_2 279714.FuraDRAFT_1512 1.09e-41 146.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,2KSRK@206351|Neisseriales 206351|Neisseriales O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_199074_1 1000565.METUNv1_03791 2.81e-141 405.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,2KV7M@206389|Rhodocyclales 206389|Rhodocyclales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1048152_1 889378.Spiaf_0779 1.26e-55 189.0 COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes 203691|Spirochaetes M LysM domain M23 M37 peptidase domain protein nlpD - - - - - - - - - - - LysM,Peptidase_M23 k59_689579_1 1198452.Jab_2c30800 2.12e-49 171.0 COG0259@1|root,COG3945@1|root,COG0259@2|Bacteria,COG3945@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,472YJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - Hemerythrin,PNP_phzG_C,Putative_PNPOx k59_689583_1 1123377.AUIV01000011_gene2093 2.29e-37 144.0 COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1XD8I@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_1117606_1 397945.Aave_1216 3.22e-46 156.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,4A9WC@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_1117606_2 1268622.AVS7_04090 5.91e-52 170.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,4AA8B@80864|Comamonadaceae 28216|Betaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_547362_1 269798.CHU_3519 4.21e-70 219.0 COG3279@1|root,COG3279@2|Bacteria,4NE6M@976|Bacteroidetes,47NFF@768503|Cytophagia 976|Bacteroidetes T LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_547362_2 1229276.DI53_0125 4.68e-28 108.0 COG2972@1|root,COG2972@2|Bacteria,4NM0E@976|Bacteroidetes 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase k59_1048189_1 1441629.PCH70_38460 2.21e-24 99.8 COG0834@1|root,COG0834@2|Bacteria,1PHYU@1224|Proteobacteria,1SYE9@1236|Gammaproteobacteria,1Z9F6@136849|Pseudomonas syringae group 1236|Gammaproteobacteria ET Bacterial periplasmic substrate-binding proteins - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_1048189_2 983920.Y88_0844 4.47e-78 242.0 COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2TU3Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the iron ascorbate-dependent oxidoreductase family - - - - - - - - - - - - 2OG-FeII_Oxy,DIOX_N k59_581612_1 596324.TREVI0001_2258 5.38e-16 80.9 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2J5H1@203691|Spirochaetes 203691|Spirochaetes M Transglycosylase - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_581612_2 1307761.L21SP2_2200 2.64e-21 91.7 COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes 203691|Spirochaetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_6,TPR_8 k59_547369_1 1089552.KI911559_gene1741 5.29e-09 58.2 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2JPA3@204441|Rhodospirillales 204441|Rhodospirillales S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_547369_2 1120977.JHUX01000003_gene1670 1.22e-06 46.2 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,3NPC2@468|Moraxellaceae 1236|Gammaproteobacteria K 'Cold-shock' DNA-binding domain capB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_371754_1 864051.BurJ1DRAFT_4175 1.86e-87 281.0 COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_405354_1 1000565.METUNv1_01138 5.19e-100 308.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,2KUU5@206389|Rhodocyclales 206389|Rhodocyclales T EAL domain - - - - - - - - - - - - EAL,GGDEF k59_938913_1 795666.MW7_2947 1.03e-149 457.0 COG1200@1|root,COG1200@2|Bacteria,1QWSU@1224|Proteobacteria,2VPIB@28216|Betaproteobacteria 28216|Betaproteobacteria KL Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C k59_726655_1 1000565.METUNv1_02541 1.16e-168 477.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,2KV7H@206389|Rhodocyclales 206389|Rhodocyclales I Desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_1012909_1 614083.AWQR01000046_gene3336 3.03e-31 118.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2VHMJ@28216|Betaproteobacteria,4AAE3@80864|Comamonadaceae 28216|Betaproteobacteria N PFAM OmpA MotB domain protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_449608_2 1122917.KB899659_gene6072 0.000163 47.8 COG5301@1|root,COG5301@2|Bacteria,1V8R8@1239|Firmicutes,4I0X7@91061|Bacilli,26YC4@186822|Paenibacillaceae 91061|Bacilli S Phage tail-collar fibre protein - - - - - - - - - - - - DUF3751 k59_520489_1 1430440.MGMSRv2_1752 2.15e-89 278.0 COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,2TTB4@28211|Alphaproteobacteria,2JPWW@204441|Rhodospirillales 204441|Rhodospirillales P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_371767_1 1226994.AMZB01000116_gene2537 2.97e-35 134.0 COG4372@1|root,COG4372@2|Bacteria,1MX74@1224|Proteobacteria,1RMWF@1236|Gammaproteobacteria,1YEBK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Transposase - - - - - - - - - - - - - k59_581628_1 272559.BF9343_3006 1.75e-57 199.0 COG0265@1|root,COG0265@2|Bacteria,4NGFM@976|Bacteroidetes,2G2PK@200643|Bacteroidia,4AW2E@815|Bacteroidaceae 976|Bacteroidetes O Domain present in PSD-95, Dlg, and ZO-1/2. - - - - - - - - - - - - Beta_helix,PDZ_2 k59_300518_1 640081.Dsui_2189 6.3e-19 85.1 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales 206389|Rhodocyclales CM Acyl-CoA synthetase (NDP forming) - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_263880_1 529818.AMSG_01589T0 9.57e-10 64.7 KOG0045@1|root,KOG3508@1|root,KOG0045@2759|Eukaryota,KOG3508@2759|Eukaryota 2759|Eukaryota P negative regulation of Ras protein signal transduction - - - ko:K04352 ko04010,ko04013,ko04014,ko04360,map04010,map04013,map04014,map04360 - - - ko00000,ko00001 - - - Calpain_III,PH,PSI,Peptidase_C2,RasGAP,TIG k59_49266_2 580332.Slit_0204 4.69e-29 107.0 2CEVW@1|root,336AF@2|Bacteria,1N7V1@1224|Proteobacteria,2VXJ3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_300525_1 948106.AWZT01000020_gene4145 6.92e-14 68.2 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,1K08U@119060|Burkholderiaceae 28216|Betaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_300525_2 204773.HEAR2899 1.99e-48 155.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,474S4@75682|Oxalobacteraceae 28216|Betaproteobacteria C 4Fe-4S binding domain fdx1 - - - - - - - - - - - Fer4,Fer4_7 k59_199175_2 1123392.AQWL01000002_gene2071 5.92e-65 207.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VQAV@28216|Betaproteobacteria,1KSQ0@119069|Hydrogenophilales 119069|Hydrogenophilales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_615838_1 1000565.METUNv1_03780 2.28e-73 246.0 COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria,2WEH7@28216|Betaproteobacteria,2KY9X@206389|Rhodocyclales 206389|Rhodocyclales S Heparinase II/III-like protein - - - - - - - - - - - - DUF4962,Hepar_II_III,VanZ k59_760524_1 1144342.PMI40_01999 2.22e-76 240.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2VH7E@28216|Betaproteobacteria,473GY@75682|Oxalobacteraceae 28216|Betaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_1012930_1 497321.C664_06288 5.24e-88 291.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_869410_2 420662.Mpe_A0851 8.61e-49 162.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,1KJS7@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_760527_1 1286093.C266_17591 6.82e-108 332.0 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,1K4KH@119060|Burkholderiaceae 28216|Betaproteobacteria P Arsenite-activated ATPase (ArsA) arsA - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase,CbiA k59_1117667_1 688245.CtCNB1_4345 3.56e-107 317.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,4AASJ@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_547410_1 1227739.Hsw_3206 4.14e-06 49.7 2C5KB@1|root,2ZCDW@2|Bacteria,4NMNY@976|Bacteroidetes,47PDN@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1117671_1 388051.AUFE01000039_gene4146 4.57e-82 259.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VHP4@28216|Betaproteobacteria,1K1E8@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307,ko:K14393 - - - - ko00000,ko02000 2.A.21,2.A.21.7 - - SSF k59_581666_1 1000565.METUNv1_00677 3.45e-107 326.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales 206389|Rhodocyclales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_49301_1 1122951.ATUE01000006_gene1499 4.49e-46 166.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,3NJRD@468|Moraxellaceae 1236|Gammaproteobacteria O Belongs to the peptidase S16 family - - - ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_49301_2 420324.KI912007_gene8868 3.04e-08 52.8 COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria,1JUXK@119045|Methylobacteriaceae 28211|Alphaproteobacteria Q PFAM thioesterase superfamily MA20_36950 - - - - - - - - - - - 4HBT k59_1048304_1 194699.Q775D4_BPBPP 2.98e-91 320.0 4QHMX@10239|Viruses,4QW8C@35237|dsDNA viruses no RNA stage,4QRQS@28883|Caudovirales,4QNWI@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_155881_1 323261.Noc_2178 0.000148 49.7 COG0438@1|root,COG1216@1|root,COG2230@1|root,COG4372@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2230@2|Bacteria,COG4372@2|Bacteria,1QP7Y@1224|Proteobacteria,1RR12@1236|Gammaproteobacteria,1WXJ8@135613|Chromatiales 135613|Chromatiales M glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23 k59_449706_1 402626.Rpic_0289 5.64e-32 119.0 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,2VJUF@28216|Betaproteobacteria,1K41P@119060|Burkholderiaceae 28216|Betaproteobacteria S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_726727_1 338969.Rfer_1336 1.15e-136 404.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,4AB8C@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_49310_1 1000565.METUNv1_00079 1.55e-209 582.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,2KUN9@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_119610_1 344747.PM8797T_08329 3.06e-42 157.0 COG2010@1|root,COG2010@2|Bacteria,2J1RW@203682|Planctomycetes 203682|Planctomycetes C Protein of unknown function (DUF1549) - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_1048340_1 929713.NIASO_15020 4.1e-09 56.2 COG0220@1|root,COG0220@2|Bacteria,4NG4V@976|Bacteroidetes,1ISBF@117747|Sphingobacteriia 976|Bacteroidetes J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_300591_2 497321.C664_00055 3.74e-14 72.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,2KU7N@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_449733_1 1121033.AUCF01000004_gene4868 1.63e-88 276.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2JRN3@204441|Rhodospirillales 204441|Rhodospirillales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1117707_1 748247.AZKH_0323 2.24e-198 565.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_799746_1 1028801.RG1141_CH25320 2.07e-37 127.0 COG3668@1|root,COG3668@2|Bacteria,1MZIN@1224|Proteobacteria,2UD9S@28211|Alphaproteobacteria,4BGCG@82115|Rhizobiaceae 28211|Alphaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_799746_2 1458427.BAWN01000094_gene2205 2.43e-77 246.0 COG5534@1|root,COG5534@2|Bacteria,1MXQ0@1224|Proteobacteria,2VJHV@28216|Betaproteobacteria,4AJBN@80864|Comamonadaceae 28216|Betaproteobacteria L Initiator Replication protein - - - - - - - - - - - - RPA k59_799746_3 1051646.VITU9109_02817 3.23e-09 60.1 COG3091@1|root,COG3091@2|Bacteria,1RBMK@1224|Proteobacteria,1S3MT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SprT-like family mpr - - - - - - - - - - - SprT-like k59_341882_1 1000565.METUNv1_01171 6.79e-106 315.0 COG0628@1|root,COG0628@2|Bacteria,1PM24@1224|Proteobacteria,2VPEN@28216|Betaproteobacteria,2KVTH@206389|Rhodocyclales 206389|Rhodocyclales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_341882_2 1000565.METUNv1_01172 7.11e-81 240.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VSUJ@28216|Betaproteobacteria,2KWMV@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_341882_4 1000565.METUNv1_01174 1.25e-09 58.9 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,2KUEB@206389|Rhodocyclales 206389|Rhodocyclales T Periplasmic domain of Sensor histidine kinase RisS - - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,RisS_PPD k59_760571_1 930166.CD58_01815 2.84e-33 117.0 COG2161@1|root,COG2161@2|Bacteria,1N8QY@1224|Proteobacteria,1SFWC@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_760571_2 1349767.GJA_1317 7.51e-38 137.0 COG0669@1|root,COG4339@1|root,COG0669@2|Bacteria,COG4339@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria 28216|Betaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1048367_1 1000565.METUNv1_02995 6.36e-26 105.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,2KUC6@206389|Rhodocyclales 206389|Rhodocyclales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1048367_2 1000565.METUNv1_02996 3.09e-18 82.8 COG1835@1|root,COG1835@2|Bacteria,1NSVZ@1224|Proteobacteria,2VKZ5@28216|Betaproteobacteria,2KW1B@206389|Rhodocyclales 206389|Rhodocyclales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_199297_1 1150626.PHAMO_260026 2.12e-54 196.0 COG0438@1|root,COG1216@1|root,COG3914@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG3914@2|Bacteria,1MVIM@1224|Proteobacteria,2TR88@28211|Alphaproteobacteria,2JUS6@204441|Rhodospirillales 204441|Rhodospirillales MO Glycosyltransferase like family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glyco_transf_41,Glycos_transf_2 k59_1117722_1 365046.Rta_33640 1e-66 213.0 COG3181@1|root,COG3181@2|Bacteria,1NEU9@1224|Proteobacteria,2VHYX@28216|Betaproteobacteria,4AC1P@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_263973_1 1000565.METUNv1_02599 5.1e-288 802.0 COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VHDQ@28216|Betaproteobacteria,2KW16@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - - - - - - - - - - GGDEF,HDOD,Response_reg k59_449776_1 580332.Slit_2418 3.55e-43 151.0 COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,2VJDC@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the NiCoT transporter (TC 2.A.52) family hoxN - - ko:K07241 - - - - ko00000,ko02000 2.A.52.1 - - NicO k59_263978_2 1437824.BN940_01686 1.39e-48 158.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2WEVR@28216|Betaproteobacteria 28216|Betaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_939005_1 1266925.JHVX01000002_gene1038 6.44e-46 170.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,372SX@32003|Nitrosomonadales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9,dCache_1 k59_1117753_1 395494.Galf_2566 9.09e-42 149.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,44VP3@713636|Nitrosomonadales 28216|Betaproteobacteria L PFAM DEAD DEAH box helicase domain protein dbpA GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_799808_1 871585.BDGL_002112 5.34e-46 166.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,3NJM2@468|Moraxellaceae 1236|Gammaproteobacteria C C-terminal domain of alpha-glycerophosphate oxidase glpD GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009331,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052590,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575,GO:1902494,GO:1990204 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - iSSON_1240.SSON_3663 DAO,DAO_C k59_302811_1 1469557.JSWF01000033_gene1611 1.15e-29 115.0 COG1680@1|root,COG1680@2|Bacteria,4NJGF@976|Bacteroidetes,1I8CS@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_202060_1 296591.Bpro_2659 1.45e-51 171.0 COG0767@1|root,COG0767@2|Bacteria,1NSBS@1224|Proteobacteria,2VKK9@28216|Betaproteobacteria,4AABS@80864|Comamonadaceae 28216|Betaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_202060_2 614083.AWQR01000005_gene1013 2.69e-13 69.3 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,4AC4P@80864|Comamonadaceae 28216|Betaproteobacteria FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_907538_1 1005048.CFU_2384 5.89e-54 178.0 COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2VK2Y@28216|Betaproteobacteria,473YF@75682|Oxalobacteraceae 28216|Betaproteobacteria E N-formylglutamate amidohydrolase hutG - 3.5.1.68,3.5.3.8 ko:K01458,ko:K01479 ko00340,ko00630,ko01100,map00340,map00630,map01100 M00045 R00525,R02285 RC00165,RC00221,RC00323,RC00681 ko00000,ko00001,ko00002,ko01000 - - - FGase k59_549522_1 1437882.AZRU01000076_gene1152 3.11e-39 138.0 COG0745@1|root,COG0745@2|Bacteria,1MWJG@1224|Proteobacteria,1RPU3@1236|Gammaproteobacteria,1YD8E@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1062326_1 1000565.METUNv1_01163 8.89e-42 145.0 2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2WGPR@28216|Betaproteobacteria,2KW4Y@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_698312_1 388051.AUFE01000033_gene3690 1.16e-124 367.0 COG1073@1|root,COG1073@2|Bacteria,1RB3T@1224|Proteobacteria,2WEIG@28216|Betaproteobacteria,1KFXD@119060|Burkholderiaceae 28216|Betaproteobacteria S alpha beta - - - - - - - - - - - - - k59_1095225_1 1000565.METUNv1_00403 1.58e-254 706.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,2KUBM@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1095225_3 1000565.METUNv1_00405 1.23e-32 118.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,2KWMK@206389|Rhodocyclales 206389|Rhodocyclales H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_535208_1 398578.Daci_3261 2.23e-23 94.4 2BA7A@1|root,323MC@2|Bacteria,1RIHY@1224|Proteobacteria,2VTIA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_382132_1 522306.CAP2UW1_0580 1.05e-07 50.8 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2VRGP@28216|Betaproteobacteria,1KQYW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K MraZ protein, putative antitoxin-like mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_382132_2 1121035.AUCH01000009_gene918 4.41e-90 273.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,2KUQH@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_946248_1 1298608.JCM18900_11975 1.76e-42 156.0 COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,1RMF5@1236|Gammaproteobacteria,3NJN2@468|Moraxellaceae 1236|Gammaproteobacteria T Histidine kinase rstB - 2.7.13.3 ko:K07639 ko02020,map02020 M00446 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_128588_2 397945.Aave_4668 1.57e-52 169.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria,4ABQB@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase yibF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_356597_1 614083.AWQR01000005_gene916 1.73e-59 199.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,4ABSD@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_413175_2 395493.BegalDRAFT_2813 1.63e-42 151.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF72 yecE - - - - - - - - - - - DUF72 k59_93355_1 395964.KE386496_gene2483 3.9e-62 204.0 COG4292@1|root,COG4292@2|Bacteria,1MW5F@1224|Proteobacteria,2TQP4@28211|Alphaproteobacteria,3NBWG@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Bacterial low temperature requirement A protein (LtrA) ltrA - - - - - - - - - - - LtrA k59_21773_1 991.IW20_20155 2.15e-72 238.0 COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,1HZCT@117743|Flavobacteriia,2NTX8@237|Flavobacterium 976|Bacteroidetes E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2,AA_permease_C k59_164759_1 342113.DM82_1913 2.21e-13 68.6 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,1K2CI@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narG - 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_1062404_1 795666.MW7_1001 3.04e-106 308.0 COG1595@1|root,COG1595@2|Bacteria,1PWG2@1224|Proteobacteria,2VNSU@28216|Betaproteobacteria,1KIMG@119060|Burkholderiaceae 28216|Betaproteobacteria K Protein of unknown function (DUF3489) - - - - - - - - - - - - DUF3489 k59_311612_1 82654.Pse7367_0596 9.6e-44 151.0 COG0605@1|root,COG0605@2|Bacteria,1G0VH@1117|Cyanobacteria,1HEXG@1150|Oscillatoriales 1117|Cyanobacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_983732_1 1266925.JHVX01000008_gene336 4.88e-19 91.3 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,37247@32003|Nitrosomonadales 28216|Betaproteobacteria I PFAM Membrane protein, aromatic hydrocarbon degradation fadL - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1062424_1 29581.BW37_03743 6.88e-156 446.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,474G1@75682|Oxalobacteraceae 28216|Betaproteobacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - DUF3369,GGDEF,HD,HD_5,Response_reg k59_273485_1 1000565.METUNv1_02489 1.31e-100 311.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - DUF2222,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_983743_1 1124780.ANNU01000013_gene3812 1.13e-62 204.0 COG0664@1|root,COG0745@1|root,COG0664@2|Bacteria,COG0745@2|Bacteria,4NFB1@976|Bacteroidetes,47JY7@768503|Cytophagia 976|Bacteroidetes K Transcriptional regulator, Crp Fnr family - - - - - - - - - - - - HTH_Crp_2,Response_reg,cNMP_binding k59_622624_1 1346330.M472_18760 1.3e-29 115.0 COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1INWD@117747|Sphingobacteriia 976|Bacteroidetes H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_622624_2 929703.KE386491_gene476 8.23e-22 92.4 COG1496@1|root,COG1496@2|Bacteria,4NM9H@976|Bacteroidetes,47JW0@768503|Cytophagia 976|Bacteroidetes S Belongs to the multicopper oxidase YfiH RL5 family - GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_1062435_1 640081.Dsui_0830 2.09e-101 304.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,2KV12@206389|Rhodocyclales 206389|Rhodocyclales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_535302_1 1223521.BBJX01000002_gene2781 5.33e-70 225.0 28MAA@1|root,2ZAP0@2|Bacteria,1R5EZ@1224|Proteobacteria,2VNTE@28216|Betaproteobacteria,4AHBF@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_535308_1 365044.Pnap_2417 1.1e-99 296.0 COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2VJ3H@28216|Betaproteobacteria,4AA1U@80864|Comamonadaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component ssuC - - ko:K15554 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.2 - - BPD_transp_1 k59_946304_2 313594.PI23P_03262 7.81e-08 53.1 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Alpha_L_fucos,CBM_3,CBM_6,Cu_amine_oxidN1,F5_F8_type_C,FIVAR,SLH,fn3 k59_535333_1 1198452.Jab_1c18890 5.63e-108 328.0 COG0382@1|root,COG0560@1|root,COG0382@2|Bacteria,COG0560@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,4751T@75682|Oxalobacteraceae 28216|Betaproteobacteria EH UbiA prenyltransferase family - - - - - - - - - - - - HAD,UbiA k59_589181_1 402612.FP0026 5.1e-28 107.0 COG1788@1|root,COG1788@2|Bacteria,4NF3T@976|Bacteroidetes,1HY5F@117743|Flavobacteriia,2NTZZ@237|Flavobacterium 976|Bacteroidetes I transferase scoA - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 ko:K01027,ko:K01028,ko:K01031,ko:K01034 ko00072,ko00280,ko00310,ko00362,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00362,map00627,map00640,map00650,map01100,map01120,map02020 - R00410,R01179,R01359,R01365,R02990,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_463658_1 614083.AWQR01000031_gene2626 2.16e-19 81.6 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,4ADW4@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR exbD1 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_463658_2 614083.AWQR01000031_gene2625 6.09e-07 49.3 COG4256@1|root,COG4256@2|Bacteria,1NGJH@1224|Proteobacteria 1224|Proteobacteria P Hemin uptake protein hmuP - - - - - - - - - - - hemP k59_1095282_1 1000565.METUNv1_00401 1.85e-308 854.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales 206389|Rhodocyclales CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1125855_1 1049564.TevJSym_aa00960 4.7e-13 74.3 COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_589198_2 270374.MELB17_10563 1.75e-26 108.0 COG2207@1|root,COG2207@2|Bacteria,1R3Q2@1224|Proteobacteria,1RZNW@1236|Gammaproteobacteria,466T4@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_382306_1 1198452.Jab_2c08180 9.52e-112 333.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,474KQ@75682|Oxalobacteraceae 28216|Betaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_946332_1 870187.Thini_3652 3.64e-141 414.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,460F9@72273|Thiotrichales 72273|Thiotrichales C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_413263_1 760117.JN27_03660 4.22e-66 209.0 COG3781@1|root,COG3781@2|Bacteria,1MX91@1224|Proteobacteria,2VHY9@28216|Betaproteobacteria,476XM@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bestrophin, RFP-TM, chloride channel - - - ko:K08994 - - - - ko00000,ko02000 1.A.46.2 - - Bestrophin k59_734864_1 1396418.BATQ01000107_gene5424 3.81e-49 176.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_589207_1 358220.C380_07480 6.54e-52 174.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,4AB6A@80864|Comamonadaceae 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_700580_1 66875.JODY01000017_gene554 1.48e-26 110.0 COG5377@1|root,COG5377@2|Bacteria,2ICCN@201174|Actinobacteria 201174|Actinobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_1096605_1 1117318.PRUB_08714 5.47e-28 115.0 28I7K@1|root,2Z8AG@2|Bacteria,1PP1H@1224|Proteobacteria,1RY90@1236|Gammaproteobacteria,2Q3VV@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4815) - - - - - - - - - - - - DUF4815 k59_624273_1 1323663.AROI01000006_gene2737 2.03e-35 132.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SpoVR family ycgB GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - ko:K06415 - - - - ko00000 - - - SpoVR k59_624273_2 1215092.PA6_037_00410 2.09e-43 152.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1YDA0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Belongs to the UPF0229 family yeaH - - ko:K09786 - - - - ko00000 - - - DUF444 k59_1096612_1 864073.HFRIS_007886 1.48e-55 179.0 COG0645@1|root,COG0645@2|Bacteria,1RDGW@1224|Proteobacteria,2VR2J@28216|Betaproteobacteria 28216|Betaproteobacteria S AAA domain - - - - - - - - - - - - AAA_33 k59_490278_1 614083.AWQR01000022_gene89 2.61e-14 71.2 COG1172@1|root,COG1172@2|Bacteria,1MWN4@1224|Proteobacteria,2VK4C@28216|Betaproteobacteria,4AGYQ@80864|Comamonadaceae 28216|Betaproteobacteria U Branched-chain amino acid transport system / permease component - - - ko:K10560 ko02010,map02010 M00220 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 - - BPD_transp_2 k59_490278_2 614083.AWQR01000022_gene88 1.09e-103 308.0 COG1172@1|root,COG1172@2|Bacteria,1MV4F@1224|Proteobacteria,2VMEC@28216|Betaproteobacteria,4AGBP@80864|Comamonadaceae 28216|Betaproteobacteria U Branched-chain amino acid transport system / permease component - - - ko:K10561 ko02010,map02010 M00220 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 - - BPD_transp_2 k59_95699_1 614083.AWQR01000001_gene3115 2.65e-101 310.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4A9UR@80864|Comamonadaceae 28216|Betaproteobacteria I AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_60036_1 1000565.METUNv1_00848 0.0 1131.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,2KUX1@206389|Rhodocyclales 206389|Rhodocyclales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_60036_2 1000565.METUNv1_00847 1.56e-86 272.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,2KUY6@206389|Rhodocyclales 206389|Rhodocyclales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_275603_1 1095769.CAHF01000011_gene2069 1.22e-92 275.0 COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,2VMIW@28216|Betaproteobacteria,4757T@75682|Oxalobacteraceae 28216|Betaproteobacteria U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_166918_1 1198452.Jab_1c13730 1.46e-85 263.0 COG3203@1|root,COG3203@2|Bacteria,1Q1XX@1224|Proteobacteria,2VRRG@28216|Betaproteobacteria,4775X@75682|Oxalobacteraceae 28216|Betaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_1024511_1 1163617.SCD_n01072 1.01e-57 196.0 COG0582@1|root,COG0582@2|Bacteria,1R4W5@1224|Proteobacteria,2WENV@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_560364_1 1000565.METUNv1_01082 1.76e-38 141.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_560364_2 1000565.METUNv1_01083 9.84e-56 173.0 COG1146@1|root,COG1146@2|Bacteria,1N06F@1224|Proteobacteria,2VUIE@28216|Betaproteobacteria 28216|Betaproteobacteria C 4fe-4S ferredoxin - - - - - - - - - - - - Fer4_7 k59_560364_3 1000565.METUNv1_01084 4.6e-155 446.0 COG0715@1|root,COG0715@2|Bacteria,1QTVG@1224|Proteobacteria,2VJVD@28216|Betaproteobacteria 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_60042_1 292.DM42_6794 2.45e-11 59.7 COG3847@1|root,COG3847@2|Bacteria,1PUR7@1224|Proteobacteria,2VXM6@28216|Betaproteobacteria,1KAXN@119060|Burkholderiaceae 28216|Betaproteobacteria U PFAM Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap k59_736732_1 1000565.METUNv1_01459 5.11e-56 179.0 2BZ0G@1|root,32R44@2|Bacteria,1RI37@1224|Proteobacteria,2VT46@28216|Betaproteobacteria,2KYZ4@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_881066_1 614083.AWQR01000038_gene1441 2.03e-35 127.0 COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,2VTQI@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_624308_1 614083.AWQR01000057_gene3658 4e-31 117.0 COG1175@1|root,COG1175@2|Bacteria,1MU84@1224|Proteobacteria,2VJFE@28216|Betaproteobacteria,4AAH9@80864|Comamonadaceae 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K17316 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 k59_624308_2 1198452.Jab_1c12230 1.81e-27 100.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2VXVA@28216|Betaproteobacteria,4755X@75682|Oxalobacteraceae 28216|Betaproteobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_624308_3 29581.BW37_01290 1.7e-09 57.4 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2VJ8T@28216|Betaproteobacteria,47385@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_415129_1 29581.BW37_00892 3.18e-110 332.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2VNY1@28216|Betaproteobacteria,473K7@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase regB - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_624314_1 1121920.AUAU01000008_gene1658 2.75e-94 278.0 COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria 57723|Acidobacteria C TIGRFAM NADH-quinone oxidoreductase, E subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_130946_1 1353529.M899_0092 1.13e-82 252.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2WKE1@28221|Deltaproteobacteria 28221|Deltaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_130948_1 1297569.MESS2_320056 1.73e-18 83.2 COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2U5JV@28211|Alphaproteobacteria,43IA8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K transcriptional regulator - - - ko:K07734 - - - - ko00000,ko03000 - - - FMN_bind_2 k59_985985_1 522306.CAP2UW1_1062 1.28e-06 50.4 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,1KPSA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_985985_2 522306.CAP2UW1_1061 2.86e-88 268.0 COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2VHP3@28216|Betaproteobacteria,1KQXD@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_881099_1 1000565.METUNv1_03998 2.7e-26 105.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VJS8@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_881099_2 1000565.METUNv1_03999 1.92e-104 308.0 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,2KX0U@206389|Rhodocyclales 206389|Rhodocyclales H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_769874_1 7213.XP_004528611.1 3.9e-19 88.6 COG0237@1|root,KOG3220@2759|Eukaryota,38DFB@33154|Opisthokonta,3BCMM@33208|Metazoa,3CYKU@33213|Bilateria,41XVB@6656|Arthropoda 33208|Metazoa H dephospho-CoA kinase activity. It is involved in the biological process described with coenzyme A biosynthetic process dcakd GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - CoaE k59_275665_1 700598.Niako_3625 2.33e-36 140.0 COG3525@1|root,COG3525@2|Bacteria,4NH5U@976|Bacteroidetes,1IQ89@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase, family 20, catalytic domain - - - - - - - - - - - - Glyco_hydro_20b k59_490364_1 1276756.AUEX01000022_gene2594 2.51e-78 252.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,4AC6C@80864|Comamonadaceae 28216|Betaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_560449_1 232721.Ajs_0690 8.53e-107 316.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4ACNQ@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_415172_1 929562.Emtol_2590 4.22e-104 335.0 COG1538@1|root,COG3696@1|root,COG1538@2|Bacteria,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47JC4@768503|Cytophagia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_385497_1 748247.AZKH_0543 3.99e-99 300.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,2KVI2@206389|Rhodocyclales 206389|Rhodocyclales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_385497_2 1218084.BBJK01000141_gene7350 6.32e-17 76.3 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,1K7QN@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_95790_1 1000565.METUNv1_00476 1.84e-122 356.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,2VQN6@28216|Betaproteobacteria,2KW7Y@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_881135_1 614083.AWQR01000038_gene1422 1.42e-70 224.0 COG2199@1|root,COG3706@2|Bacteria,1R6GI@1224|Proteobacteria,2VM5N@28216|Betaproteobacteria,4A9XC@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_853451_2 1276756.AUEX01000031_gene137 2.75e-73 226.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,4A9J7@80864|Comamonadaceae 28216|Betaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1133758_1 700598.Niako_6069 8.55e-15 77.8 COG0705@1|root,COG0705@2|Bacteria,4NGVJ@976|Bacteroidetes,1IS2B@117747|Sphingobacteriia 976|Bacteroidetes S Rhomboid family - - - - - - - - - - - - Rhomboid k59_497458_1 365046.Rta_05080 1.54e-81 263.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,4AA54@80864|Comamonadaceae 28216|Betaproteobacteria CO PFAM cytochrome c biogenesis protein, transmembrane region - - 1.8.1.8 ko:K04084,ko:K08344 - - - - ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.5 - - DsbC,DsbD,Thioredoxin_7 k59_628337_1 471854.Dfer_3267 1.35e-34 133.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,47JEH@768503|Cytophagia 976|Bacteroidetes F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_420346_1 1198452.Jab_2c14610 1.69e-83 268.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QTVF@1224|Proteobacteria 1224|Proteobacteria P Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_888917_1 83406.HDN1F_35940 2.26e-105 314.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,1RN4Z@1236|Gammaproteobacteria,1J7IT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - 3.1.4.54 ko:K13985 ko04723,map04723 - - - ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_281368_1 614083.AWQR01000029_gene2134 3.73e-50 164.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,4ABG3@80864|Comamonadaceae 28216|Betaproteobacteria D Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_173153_1 582744.Msip34_2809 4.44e-67 209.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,2KKWZ@206350|Nitrosomonadales 206350|Nitrosomonadales O Thiol disulfide interchange protein - - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_497485_1 269796.Rru_A0935 9.22e-41 143.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,2JPF2@204441|Rhodospirillales 204441|Rhodospirillales GM GDP-mannose 4,6 dehydratase - - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1100367_1 1000565.METUNv1_02559 5.65e-105 315.0 COG4222@1|root,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,2VM0N@28216|Betaproteobacteria,2KWFH@206389|Rhodocyclales 206389|Rhodocyclales S Esterase-like activity of phytase - - - - - - - - - - - - Phytase-like k59_566343_1 296591.Bpro_1864 2.12e-46 151.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSKZ@28216|Betaproteobacteria,4ADX0@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM peptidylprolyl isomerase FKBP-type fkpA - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_566343_2 338969.Rfer_0060 1.2e-76 235.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,4ADSA@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM Cyclic nucleotide-binding dnrD - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_420369_1 1000565.METUNv1_00046 2.31e-107 347.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_29273_1 640081.Dsui_1445 7.71e-126 367.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,2KV9X@206389|Rhodocyclales 206389|Rhodocyclales F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_29273_2 232721.Ajs_4046 3.24e-183 511.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,4AB9Z@80864|Comamonadaceae 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_281399_1 1198452.Jab_2c15460 4.29e-107 313.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,472QR@75682|Oxalobacteraceae 28216|Betaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_706113_1 1005048.CFU_4120 1.18e-42 148.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,4728D@75682|Oxalobacteraceae 28216|Betaproteobacteria D Actin mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_853546_1 1123368.AUIS01000006_gene565 7.3e-06 54.3 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RX09@1236|Gammaproteobacteria,2NDV0@225057|Acidithiobacillales 225057|Acidithiobacillales T diguanylate cyclase - - - - - - - - - - - - GGDEF,HDOD,Response_reg k59_238348_1 311403.Arad_1943 2.54e-24 103.0 COG4122@1|root,COG4122@2|Bacteria,1RKBS@1224|Proteobacteria,2UE6R@28211|Alphaproteobacteria,4B85M@82115|Rhizobiaceae 28211|Alphaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_888978_1 614083.AWQR01000021_gene220 6.86e-117 343.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,4ABVH@80864|Comamonadaceae 28216|Betaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_566369_3 1636270.A0A0E3M2T0_9CAUD 2.53e-22 95.1 4QGUX@10239|Viruses,4QSCB@28883|Caudovirales,4QNT7@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1133825_1 652103.Rpdx1_1163 4.24e-33 124.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TSAT@28211|Alphaproteobacteria,3JUQQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Belongs to the NadC ModD family modD - - ko:K03813 - - - - ko00000,ko01000 - - - QRPTase_C,QRPTase_N k59_102064_1 1122605.KB893641_gene3034 2.67e-75 244.0 COG0436@1|root,COG0436@2|Bacteria,4NEN3@976|Bacteroidetes,1IQM1@117747|Sphingobacteriia 976|Bacteroidetes E PFAM RagB SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_742981_1 685727.REQ_01410 1.67e-64 211.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FVUB@85025|Nocardiaceae 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_774902_1 358220.C380_20235 7.38e-67 207.0 COG1522@1|root,COG1522@2|Bacteria,1RD38@1224|Proteobacteria,2VRBA@28216|Betaproteobacteria,4ADWA@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein AsnC Lrp family - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_993588_1 1397527.Q670_16615 2.11e-35 134.0 COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,1S029@1236|Gammaproteobacteria,1XKMX@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_104666_1 1045855.DSC_06030 3.83e-78 246.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RRAS@1236|Gammaproteobacteria,1X2ZW@135614|Xanthomonadales 135614|Xanthomonadales S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_993593_1 543728.Vapar_0311 1.89e-78 243.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VNXZ@28216|Betaproteobacteria,4ACG7@80864|Comamonadaceae 28216|Betaproteobacteria ET PFAM Extracellular solute-binding protein, family 3 - - - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_568928_1 338966.Ppro_2723 1.59e-15 77.8 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R7R@68525|delta/epsilon subdivisions,2WMT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - - - - - - - - - - GerE,HATPase_c,HisKA,PAS,Response_reg k59_568928_2 1121035.AUCH01000028_gene3258 2.1e-09 58.5 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2VIT3@28216|Betaproteobacteria,2KUC5@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD_5,Response_reg k59_104700_1 1458275.AZ34_16955 5.42e-150 435.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,4AAW8@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_568965_1 1417296.U879_11205 5.6e-09 57.4 COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes MA20_44635 - - - - - - - - - - - NUDIX k59_568965_2 1121033.AUCF01000004_gene4930 9.81e-60 187.0 COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria,2JSTU@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF1285) - - - ko:K09986 - - - - ko00000 - - - DUF1285 k59_856448_1 292415.Tbd_2174 2.26e-27 113.0 COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,2VNAW@28216|Betaproteobacteria,1KRQW@119069|Hydrogenophilales 119069|Hydrogenophilales O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_422731_1 686578.AFFX01000010_gene2308 4.14e-12 72.0 COG2207@1|root,COG2207@2|Bacteria,1RB13@1224|Proteobacteria,1S2ZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_598089_1 1000565.METUNv1_01311 1.11e-118 358.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,2KUWJ@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_175986_1 1268622.AVS7_00507 1.14e-94 289.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,4AC12@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_138848_1 1349767.GJA_859 4.7e-61 211.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,475Z8@75682|Oxalobacteraceae 28216|Betaproteobacteria V AcrB/AcrD/AcrF family mdtC3 - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_31573_1 883126.HMPREF9710_04049 1.69e-08 56.6 COG3729@1|root,COG3729@2|Bacteria,1NH1J@1224|Proteobacteria,2VY5U@28216|Betaproteobacteria,4754J@75682|Oxalobacteraceae 28216|Betaproteobacteria S Stress-induced bacterial acidophilic repeat motif - - - ko:K06884 - - - - ko00000 - - - KGG k59_569016_1 991.IW20_17050 3.63e-87 270.0 COG3538@1|root,COG3538@2|Bacteria,4NGY6@976|Bacteroidetes,1HXSN@117743|Flavobacteriia,2NTNE@237|Flavobacterium 976|Bacteroidetes S Pfam:DUF1237 - - - ko:K09704 - - - - ko00000 - - - Glyco_hydro_125 k59_777422_1 1123072.AUDH01000008_gene279 3.15e-67 227.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2JPTK@204441|Rhodospirillales 204441|Rhodospirillales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_993696_1 358220.C380_17290 1.54e-75 239.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,4AA28@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM MscS Mechanosensitive ion channel aefA - - - - - - - - - - - MS_channel k59_176025_1 700598.Niako_6916 5.03e-20 88.6 COG1277@1|root,COG1277@2|Bacteria,4NICG@976|Bacteroidetes 976|Bacteroidetes S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_176025_2 1123248.KB893332_gene2252 6.37e-21 90.1 29C3H@1|root,32VP8@2|Bacteria,4NXVV@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_422778_1 640081.Dsui_2195 2.32e-112 335.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KU9B@206389|Rhodocyclales 206389|Rhodocyclales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1102257_2 686340.Metal_2882 1.64e-34 121.0 2D16E@1|root,331SX@2|Bacteria,1NAS7@1224|Proteobacteria,1T11A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Motility quorum-sensing regulator, toxin of MqsA - - - ko:K13651 - - - - ko00000,ko02048 - - - MqsR_toxin k59_1102257_3 637390.AFOH01000041_gene2301 4.2e-23 91.7 COG2944@1|root,COG2944@2|Bacteria,1RJY8@1224|Proteobacteria,1SPEB@1236|Gammaproteobacteria,2NDUT@225057|Acidithiobacillales 225057|Acidithiobacillales K Antitoxin component of bacterial toxin-antitoxin system, MqsA - - - ko:K13655 - - - - ko00000,ko02048,ko03000 - - - MqsA_antitoxin k59_817815_2 614083.AWQR01000017_gene2241 3.14e-42 147.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,4ABBB@80864|Comamonadaceae 28216|Betaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_746085_1 1304875.JAFZ01000002_gene272 8.01e-16 81.6 COG0474@1|root,COG0474@2|Bacteria,3TBY8@508458|Synergistetes 508458|Synergistetes P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1102269_1 7159.AAEL016973-PA 0.000123 50.4 KOG1911@1|root,KOG1911@2759|Eukaryota,3A4DJ@33154|Opisthokonta,3BRD1@33208|Metazoa,3D884@33213|Bilateria,41ZRX@6656|Arthropoda,3SN0B@50557|Insecta,453FP@7147|Diptera,45KME@7148|Nematocera 33208|Metazoa B Chromo (CHRromatin Organisation MOdifier) domain - - - - - - - - - - - - Chromo k59_240860_1 1122604.JONR01000020_gene537 1.22e-68 222.0 COG1020@1|root,COG1020@2|Bacteria,1QXFM@1224|Proteobacteria,1T3AN@1236|Gammaproteobacteria,1X77R@135614|Xanthomonadales 135614|Xanthomonadales Q D-alanine [D-alanyl carrier protein] ligase activity - - - - - - - - - - - - - k59_31645_1 925409.KI911562_gene2252 1.21e-123 364.0 COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,1IP3U@117747|Sphingobacteriia 976|Bacteroidetes C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex pdhC - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_31652_1 614083.AWQR01000023_gene164 1.75e-52 186.0 COG2931@1|root,COG4886@1|root,COG2931@2|Bacteria,COG4886@2|Bacteria,1QQDR@1224|Proteobacteria,2VK3B@28216|Betaproteobacteria,4AERX@80864|Comamonadaceae 28216|Betaproteobacteria Q Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - k59_630143_1 1235457.C404_00645 6.1e-54 190.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GAF_2,GGDEF,HAMP,MASE3,PAS,PAS_4,PAS_8,dCache_3 k59_777530_1 760117.JN27_16645 3.2e-66 204.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,4746T@75682|Oxalobacteraceae 28216|Betaproteobacteria S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY k59_68042_1 1348657.M622_16165 6.06e-38 130.0 2A66X@1|root,30UZE@2|Bacteria,1N0ZY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_68042_2 1348657.M622_16160 4.42e-24 94.0 COG1395@1|root,COG1395@2|Bacteria,1QWRV@1224|Proteobacteria 1224|Proteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 k59_422863_1 296591.Bpro_3228 9.43e-57 186.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,4AC2N@80864|Comamonadaceae 28216|Betaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_422863_2 614083.AWQR01000030_gene2748 1.86e-14 72.4 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4AARD@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_569121_1 1348657.M622_12835 1.48e-73 232.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2VJD3@28216|Betaproteobacteria,2KY57@206389|Rhodocyclales 206389|Rhodocyclales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_746174_1 1000565.METUNv1_01879 1.48e-103 310.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KURK@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_176157_1 159087.Daro_3976 2.32e-98 292.0 COG0834@1|root,COG0834@2|Bacteria,1R7DC@1224|Proteobacteria,2VP65@28216|Betaproteobacteria 28216|Betaproteobacteria ET Amino Acid - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_176157_2 159087.Daro_3975 8.59e-38 140.0 COG2199@1|root,COG3614@1|root,COG2199@2|Bacteria,COG3614@2|Bacteria,1RGCV@1224|Proteobacteria,2WGZP@28216|Betaproteobacteria,2KVQG@206389|Rhodocyclales 206389|Rhodocyclales T CHASE - - - - - - - - - - - - CHASE,GGDEF,PAS_3 k59_630174_1 614083.AWQR01000044_gene2029 2.31e-57 188.0 COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,4ABFG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM VanZ family protein - - - - - - - - - - - - VanZ k59_630174_2 358220.C380_01800 5.87e-11 59.7 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,4ADZI@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM conserved - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_746200_1 1121898.Q766_09265 5.42e-18 86.7 COG1195@1|root,COG1195@2|Bacteria,4NFHN@976|Bacteroidetes,1HX8P@117743|Flavobacteriia,2NSEV@237|Flavobacterium 976|Bacteroidetes L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_15,SMC_N k59_139033_1 204773.HEAR0423 2.39e-48 157.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,47416@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ebsC - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_139033_2 1198452.Jab_2c27730 8.48e-25 97.4 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,472B0@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_598286_1 614083.AWQR01000039_gene1456 6.82e-121 359.0 COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,2WH2Q@28216|Betaproteobacteria,4AK3F@80864|Comamonadaceae 28216|Betaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_777595_1 1121920.AUAU01000016_gene1310 2.81e-100 312.0 COG1009@1|root,COG1009@2|Bacteria,3Y2VS@57723|Acidobacteria 57723|Acidobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_746214_1 1234364.AMSF01000018_gene1411 1.86e-48 168.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_708560_1 76869.PputGB1_0017 4.4e-108 332.0 COG2132@1|root,COG3667@1|root,COG2132@2|Bacteria,COG3667@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1YXW7@136845|Pseudomonas putida group 1236|Gammaproteobacteria PQ Multicopper oxidase copA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_39784_1 1123504.JQKD01000002_gene3698 1.38e-41 153.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VI4C@28216|Betaproteobacteria,4ABPE@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Extracellular ligand-binding receptor - - - - - - - - - - - - Peripla_BP_6 k59_681198_1 1131813.AQVT01000001_gene1308 0.000183 48.9 COG3637@1|root,COG3637@2|Bacteria,1MVJR@1224|Proteobacteria,2U7C3@28211|Alphaproteobacteria,1JU8Q@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl k59_896389_1 1000565.METUNv1_04055 2.93e-40 148.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_10 k59_896389_2 94624.Bpet4664 3.3e-45 156.0 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2VJ39@28216|Betaproteobacteria 28216|Betaproteobacteria S cytoplasmic chaperone TorD family protein torD - - - - - - - - - - - Nitrate_red_del k59_824429_1 761193.Runsl_2709 3.1e-87 263.0 COG3279@1|root,COG3279@2|Bacteria,4NN68@976|Bacteroidetes,47MVF@768503|Cytophagia 976|Bacteroidetes T LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_1002796_1 1218074.BAXZ01000024_gene4354 4.21e-22 104.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K2HZ@119060|Burkholderiaceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_326388_1 1000565.METUNv1_00127 5.29e-152 452.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_859683_1 1000565.METUNv1_02759 5.39e-107 328.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_647814_1 338969.Rfer_0385 9.98e-95 293.0 COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2VN6N@28216|Betaproteobacteria,4AEZ2@80864|Comamonadaceae 28216|Betaproteobacteria C e3 binding domain - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_110400_1 580332.Slit_2201 2.49e-43 148.0 COG0349@1|root,COG0349@2|Bacteria,1REMB@1224|Proteobacteria,2VQQC@28216|Betaproteobacteria,44WFH@713636|Nitrosomonadales 28216|Betaproteobacteria L 3'-5' exonuclease - - - - - - - - - - - - DNA_pol_A_exo1 k59_110400_2 1000565.METUNv1_03565 9.78e-69 211.0 COG1335@1|root,COG1335@2|Bacteria,1MWFQ@1224|Proteobacteria,2VKV5@28216|Betaproteobacteria,2KXVG@206389|Rhodocyclales 206389|Rhodocyclales Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_433486_1 1415779.JOMH01000001_gene628 1.82e-129 377.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1X397@135614|Xanthomonadales 135614|Xanthomonadales C also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_681214_1 1121035.AUCH01000004_gene332 1.46e-54 185.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VIZB@28216|Betaproteobacteria,2KVCC@206389|Rhodocyclales 1224|Proteobacteria C Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF k59_1076171_1 987059.RBXJA2T_07718 1.41e-64 204.0 COG1468@1|root,COG1468@2|Bacteria,1MX2S@1224|Proteobacteria,2VR7Q@28216|Betaproteobacteria,1KNAI@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Domain of unknown function DUF83 cas4 - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k59_1076171_2 76114.ebA3283 6.03e-69 219.0 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,2VKH8@28216|Betaproteobacteria,2KY53@206389|Rhodocyclales 206389|Rhodocyclales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_361017_1 62928.azo0660 6.02e-86 271.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales 206389|Rhodocyclales V COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_647843_1 375286.mma_1298 3.47e-134 384.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,472AU@75682|Oxalobacteraceae 28216|Betaproteobacteria G Inositol monophosphatase family suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_289759_1 365046.Rta_00350 1.21e-100 297.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,2VJFP@28216|Betaproteobacteria,4A9V6@80864|Comamonadaceae 28216|Betaproteobacteria D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_289759_2 358220.C380_00820 7.47e-47 151.0 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,2VTX1@28216|Betaproteobacteria,4AEWV@80864|Comamonadaceae 28216|Betaproteobacteria D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k59_538510_1 1000565.METUNv1_01497 1.9e-64 204.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,2KUDJ@206389|Rhodocyclales 206389|Rhodocyclales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_538510_2 1000565.METUNv1_01498 1.7e-89 263.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,2KX0Y@206389|Rhodocyclales 206389|Rhodocyclales S stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_396899_1 1000565.METUNv1_03021 1.19e-155 446.0 COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,2VHS2@28216|Betaproteobacteria,2KVZT@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_396899_2 1000565.METUNv1_03022 9.51e-141 400.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2WEGN@28216|Betaproteobacteria,2KVA1@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex LolCDE involved in the translocation of - - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_1109604_1 1122236.KB905141_gene1318 2.78e-81 246.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VRZD@28216|Betaproteobacteria,2KKSS@206350|Nitrosomonadales 206350|Nitrosomonadales S Flavodoxin domain - - - - - - - - - - - - FMN_red k59_3508_1 1000565.METUNv1_02507 4.38e-127 392.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KV93@206389|Rhodocyclales 206389|Rhodocyclales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_609274_1 1454004.AW11_02347 1.86e-47 153.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,1KQVY@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_609274_2 522306.CAP2UW1_1216 1.52e-51 166.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2VSDF@28216|Betaproteobacteria,1KQ45@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K MerR HTH family regulatory protein ycgE - - - - - - - - - - - MerR_1 k59_433531_1 1177154.Y5S_02819 7.23e-72 229.0 COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,1RPWG@1236|Gammaproteobacteria,1XNGD@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - - k59_1109606_1 1000565.METUNv1_00159 4.91e-203 574.0 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria,2KV32@206389|Rhodocyclales 206389|Rhodocyclales S fad dependent oxidoreductase - - - ko:K07137 - - - - ko00000 - - - HI0933_like k59_1109606_2 1120980.JQKH01000042_gene1597 1.73e-11 64.7 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,2KQFX@206351|Neisseriales 206351|Neisseriales S SPFH domain-Band 7 family - - - - - - - - - - - - Band_7_1,SHOCT k59_859717_1 1000565.METUNv1_03907 1.92e-132 386.0 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,2KUJS@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_896451_1 1000565.METUNv1_03154 1.36e-137 395.0 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,2VRK0@28216|Betaproteobacteria,2KWDG@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_505013_1 1210884.HG799466_gene12576 1e-36 140.0 COG0222@1|root,COG0222@2|Bacteria,2J50P@203682|Planctomycetes 203682|Planctomycetes J Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - VCBS k59_1076232_1 1000565.METUNv1_00380 8.21e-150 438.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_183613_1 1000565.METUNv1_02746 3.4e-63 213.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KUJG@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_361055_1 582744.Msip34_2104 8.27e-45 149.0 COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,2VSDZ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM DoxX family protein - - - ko:K15977 - - - - ko00000 - - - DoxX k59_361055_2 709797.CSIRO_0356 3.08e-06 50.8 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JTXD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potG GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11076 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - ABC_tran,TOBE_2 k59_717863_1 395961.Cyan7425_4889 1.33e-40 145.0 COG0754@1|root,COG0754@2|Bacteria,1G4ND@1117|Cyanobacteria 1117|Cyanobacteria E Glutathionylspermidine synthase - - - - - - - - - - - - GSP_synth k59_717863_2 1396418.BATQ01000018_gene4151 3.27e-19 84.7 COG0583@1|root,COG0583@2|Bacteria,46V15@74201|Verrucomicrobia,2IUGE@203494|Verrucomicrobiae 203494|Verrucomicrobiae K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_433585_1 1000565.METUNv1_00711 3.26e-170 480.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,2KUVW@206389|Rhodocyclales 206389|Rhodocyclales M UDP-glucose 4-epimerase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_146015_1 365044.Pnap_3613 9.96e-108 321.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,4AC0Z@80864|Comamonadaceae 28216|Betaproteobacteria H AMP-binding enzyme paaK_2 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_183640_3 906968.Trebr_1431 1.58e-28 107.0 COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes 203691|Spirochaetes L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_824524_2 1000565.METUNv1_01919 3e-77 241.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,2KUR1@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_39886_1 1000565.METUNv1_02383 6.45e-27 105.0 COG1493@1|root,COG1493@2|Bacteria,1QWDD@1224|Proteobacteria,2WH4H@28216|Betaproteobacteria 28216|Betaproteobacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - - - - - - - - - - - k59_39886_2 1000565.METUNv1_02382 3.23e-152 437.0 28JAH@1|root,2Z95A@2|Bacteria,1MXKT@1224|Proteobacteria,2VI69@28216|Betaproteobacteria,2KW5D@206389|Rhodocyclales 206389|Rhodocyclales S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 k59_647937_1 1304883.KI912532_gene2274 8.37e-112 339.0 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,2KVDI@206389|Rhodocyclales 206389|Rhodocyclales S transport system, permease and ATPase - - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2,ABC_tran k59_326513_1 946483.Cenrod_2703 8.55e-195 550.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria,4ABKU@80864|Comamonadaceae 28216|Betaproteobacteria V N-6 DNA Methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_538556_1 1000565.METUNv1_02631 9.23e-223 633.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,2KUWV@206389|Rhodocyclales 206389|Rhodocyclales N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_1039249_1 938709.AUSH02000073_gene1706 3.93e-36 143.0 COG1572@1|root,COG3210@1|root,COG3291@1|root,COG4935@1|root,COG5492@1|root,COG1572@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,COG5492@2|Bacteria,4NDZQ@976|Bacteroidetes 976|Bacteroidetes H Gliding motility-associated C-terminal domain - - - - - - - - - - - - CHU_C,HYR,P_proprotein,SprB k59_253993_1 1230460.C495_02780 1.13e-11 68.9 COG0705@1|root,COG3582@1|root,arCOG01768@2157|Archaea,arCOG01769@2157|Archaea,2XTJH@28890|Euryarchaeota,23SS3@183963|Halobacteria 183963|Halobacteria E nucleic acid binding protein containing the AN1-type Zn-finger - - - ko:K07059 - - - - ko00000 - - - Rhomboid,zf-AN1 k59_146026_1 857087.Metme_4243 1.51e-15 74.3 28K33@1|root,2Z9SC@2|Bacteria,1Q1U9@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_146026_2 323848.Nmul_A0256 1.17e-71 227.0 COG0673@1|root,COG0673@2|Bacteria,1PE87@1224|Proteobacteria,2W9B1@28216|Betaproteobacteria,374HB@32003|Nitrosomonadales 28216|Betaproteobacteria C Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_505071_2 215803.DB30_6379 4.83e-43 145.0 COG4319@1|root,COG4319@2|Bacteria,1N1VU@1224|Proteobacteria,439R2@68525|delta/epsilon subdivisions,2X53Q@28221|Deltaproteobacteria,2Z02H@29|Myxococcales 28221|Deltaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_681276_1 1136417.AZWE01000019_gene4040 6.84e-36 132.0 COG0523@1|root,COG0523@2|Bacteria,2GKDR@201174|Actinobacteria,4DH0B@85008|Micromonosporales 201174|Actinobacteria S cobalamin synthesis protein, P47K - - - - - - - - - - - - CobW_C,cobW k59_681276_2 903818.KI912268_gene3058 2.07e-34 127.0 COG0803@1|root,COG0803@2|Bacteria,3Y97A@57723|Acidobacteria 57723|Acidobacteria P Zinc-uptake complex component A periplasmic - - - ko:K02077 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ZnuA k59_717882_1 614083.AWQR01000030_gene2810 3.2e-79 247.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,4ABTG@80864|Comamonadaceae 28216|Betaproteobacteria M Nlpbdapx family lipoprotein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_110481_1 1178825.ALIH01000012_gene1818 7.91e-07 53.9 COG5661@1|root,COG5661@2|Bacteria,4NW11@976|Bacteroidetes,1I32R@117743|Flavobacteriia 976|Bacteroidetes O secreted Zn-dependent protease - - - - - - - - - - - - DUF922 k59_930879_1 394221.Mmar10_0473 7.04e-51 184.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,43W9P@69657|Hyphomonadaceae 28211|Alphaproteobacteria O M13 family peptidase - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_433649_1 1111728.ATYS01000016_gene4670 2.64e-12 64.7 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1RPXM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NADPH-dependent FMN reductase wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red,Flavodoxin_5 k59_433649_2 216142.LT40_11455 3.43e-29 112.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,1RNVS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the pirin family Z012_11830 - - ko:K06911 - - - - ko00000 - - - Pirin k59_361105_1 29581.BW37_00381 5.38e-124 359.0 COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2VHQZ@28216|Betaproteobacteria,473RH@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phenylacetic acid catabolic protein paaA - 1.14.13.149 ko:K02609 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC k59_896515_1 477184.KYC_16647 2.63e-50 173.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,3T2B4@506|Alcaligenaceae 28216|Betaproteobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_896515_2 1000565.METUNv1_00776 1.37e-64 200.0 COG1846@1|root,COG1846@2|Bacteria,1RH1F@1224|Proteobacteria,2VRNB@28216|Betaproteobacteria,2KX4R@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_539592_1 1380380.JIAX01000012_gene365 4.94e-31 126.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_7 k59_328380_1 614083.AWQR01000044_gene2026 1.31e-93 283.0 COG0598@1|root,COG0598@2|Bacteria,1NWUN@1224|Proteobacteria,2VKVR@28216|Betaproteobacteria,4AATD@80864|Comamonadaceae 28216|Betaproteobacteria P Mg2 transporter protein cora family protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_4615_1 1000565.METUNv1_03758 9.48e-09 55.1 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KUXN@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_4615_2 1000565.METUNv1_03757 9.62e-112 338.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VMAH@28216|Betaproteobacteria,2KUGS@206389|Rhodocyclales 206389|Rhodocyclales C Protein of unknown function (DUF3485) - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_435603_1 1121035.AUCH01000009_gene931 1.38e-74 249.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_610074_1 1000565.METUNv1_00170 7.28e-145 414.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,2KVVV@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_610074_2 85643.Tmz1t_3411 4.03e-13 64.3 COG4390@1|root,COG4390@2|Bacteria,1N8RK@1224|Proteobacteria,2VUJW@28216|Betaproteobacteria,2KWNK@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - - - - - - - - - - DUF2322 k59_435609_1 1000565.METUNv1_02929 5.81e-106 319.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,2KV1S@206389|Rhodocyclales 206389|Rhodocyclales D peptidase, M23 - - - - - - - - - - - - Peptidase_M23 k59_435609_2 1000565.METUNv1_02930 4.53e-122 360.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KUHV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_860651_1 1000565.METUNv1_03858 3.72e-43 151.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,2KUHQ@206389|Rhodocyclales 206389|Rhodocyclales E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_860651_2 1000565.METUNv1_03859 4.66e-80 246.0 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,2VV7N@28216|Betaproteobacteria,2KWY6@206389|Rhodocyclales 206389|Rhodocyclales S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_860651_3 497321.C664_19251 3.61e-10 63.2 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VN53@28216|Betaproteobacteria,2KVZK@206389|Rhodocyclales 206389|Rhodocyclales I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_291252_1 614083.AWQR01000018_gene1873 1.45e-116 337.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,4A9QD@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family phbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_41127_1 1111730.ATTM01000004_gene2157 3.55e-05 45.1 COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,1HYS0@117743|Flavobacteriia 976|Bacteroidetes Q ubiE/COQ5 methyltransferase family arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 k59_41127_2 525257.HMPREF0204_14968 1.02e-54 172.0 COG0640@1|root,COG0640@2|Bacteria,4NQK3@976|Bacteroidetes,1I8UI@117743|Flavobacteriia,3ZUEE@59732|Chryseobacterium 976|Bacteroidetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_20,HTH_5 k59_575006_1 397945.Aave_4225 4.69e-45 152.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,4AB7N@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase SDR - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 ko:K00059,ko:K03793 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_575006_2 296591.Bpro_4088 2.41e-51 164.0 COG1539@1|root,COG1539@2|Bacteria,1RD8Q@1224|Proteobacteria,2VR6E@28216|Betaproteobacteria,4ADXQ@80864|Comamonadaceae 28216|Betaproteobacteria H dihydroneopterin aldolase - - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_860654_1 1000565.METUNv1_02994 3.38e-127 364.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,2KUFM@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_291254_1 358220.C380_01270 2.88e-146 419.0 COG3181@1|root,COG3181@2|Bacteria,1Q5FF@1224|Proteobacteria,2VIJ9@28216|Betaproteobacteria,4AAY7@80864|Comamonadaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_790572_1 522306.CAP2UW1_2591 1.2e-129 375.0 COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,2VNMR@28216|Betaproteobacteria 28216|Betaproteobacteria GM Nad-dependent epimerase dehydratase - - - - - - - - - - - - DoxX_3,Epimerase,NAD_binding_10 k59_790572_2 522306.CAP2UW1_2590 1.93e-92 272.0 COG5528@1|root,COG5528@2|Bacteria,1RDUE@1224|Proteobacteria,2VRK8@28216|Betaproteobacteria 28216|Betaproteobacteria S Predicted integral membrane protein (DUF2269) - - - - - - - - - - - - DUF2269 k59_120871_2 321846.PS417_15845 2.82e-10 61.6 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1S2VW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - DUF4010,MgtC k59_52238_1 1157708.KB907459_gene2082 7.12e-92 280.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,4AA0T@80864|Comamonadaceae 28216|Betaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1053380_1 1215092.PA6_003_00280 1.7e-51 164.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S4NE@1236|Gammaproteobacteria,1YFY4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KT Response regulator receiver domain pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_1053380_2 349521.HCH_00544 1.96e-09 57.4 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1XKR5@135619|Oceanospirillales 135619|Oceanospirillales NT Chemotaxis signal transduction protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_226608_1 690597.JH730947_gene1012 2.27e-50 181.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,1T53M@1236|Gammaproteobacteria,1YUJ6@136843|Pseudomonas fluorescens group 1224|Proteobacteria Q Domain of unknown function (DUF4347) - - - - - - - - - - - - DUF4214,DUF4347,FecR,He_PIG,PATR k59_1120580_1 614083.AWQR01000034_gene3574 5.65e-83 254.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2VHHM@28216|Betaproteobacteria,4AEV1@80864|Comamonadaceae 28216|Betaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_15858_1 338969.Rfer_3017 1.86e-20 87.4 COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria,4AC2K@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR gno2 - - - - - - - - - - - adh_short_C2 k59_15858_2 1504672.669787302 4.28e-86 260.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VHU8@28216|Betaproteobacteria,4ABDR@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family fabG3 - - - - - - - - - - - adh_short,adh_short_C2 k59_763095_2 365044.Pnap_3153 3.35e-37 139.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4ACRA@80864|Comamonadaceae 28216|Betaproteobacteria NU General secretory system II, protein E domain protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_346751_1 1268622.AVS7_04539 2.71e-14 71.2 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,4AAB8@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_346751_2 614083.AWQR01000005_gene1050 4e-99 292.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,4ABH9@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_480921_1 399795.CtesDRAFT_PD1329 2.55e-13 75.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AAGH@80864|Comamonadaceae 28216|Betaproteobacteria NT chemotaxis - - - - - - - - - - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_407932_1 1000565.METUNv1_00846 4.31e-28 108.0 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,2KVYJ@206389|Rhodocyclales 206389|Rhodocyclales L May be involved in recombination rdgC - - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_15868_1 1000565.METUNv1_01497 7.25e-127 367.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,2KUDJ@206389|Rhodocyclales 206389|Rhodocyclales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_52261_1 1198452.Jab_1c16310 9.98e-15 72.4 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,472XS@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_52261_2 375286.mma_0530 6.13e-39 139.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,2VJTZ@28216|Betaproteobacteria,473Y8@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_226624_2 1000565.METUNv1_02091 5.36e-103 301.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,2KWGM@206389|Rhodocyclales 206389|Rhodocyclales O oxidase assembly - - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_837618_1 748247.AZKH_3592 2.81e-174 506.0 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2VN03@28216|Betaproteobacteria,2KV9N@206389|Rhodocyclales 206389|Rhodocyclales S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3,Polysacc_synt_C k59_802914_1 204773.HEAR0435 1.04e-119 354.0 COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,2WEGM@28216|Betaproteobacteria,478WF@75682|Oxalobacteraceae 28216|Betaproteobacteria T HD domain - - - - - - - - - - - - HD_5 k59_226630_1 1488328.JMCL01000060_gene3632 1.62e-100 307.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_525637_1 522306.CAP2UW1_0521 3.05e-30 124.0 COG0840@1|root,COG2703@1|root,COG4564@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Hemerythrin,MCPsignal,dCache_2 k59_226640_1 7425.NV11481-PA 6.49e-07 56.2 COG1112@1|root,KOG1804@2759|Eukaryota,38EBX@33154|Opisthokonta,3BCEQ@33208|Metazoa,3CW4Y@33213|Bilateria,41UW6@6656|Arthropoda,3SKCP@50557|Insecta,46H01@7399|Hymenoptera 33208|Metazoa L AAA domain MOV10L1 GO:0000003,GO:0000166,GO:0000184,GO:0000226,GO:0000280,GO:0000287,GO:0000578,GO:0000956,GO:0002064,GO:0002065,GO:0002066,GO:0003002,GO:0003006,GO:0003008,GO:0003674,GO:0003676,GO:0003678,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006996,GO:0007010,GO:0007017,GO:0007028,GO:0007049,GO:0007127,GO:0007140,GO:0007141,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007292,GO:0007293,GO:0007304,GO:0007306,GO:0007308,GO:0007309,GO:0007314,GO:0007315,GO:0007318,GO:0007350,GO:0007351,GO:0007389,GO:0007517,GO:0007610,GO:0007611,GO:0007613,GO:0007616,GO:0008026,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0008283,GO:0008358,GO:0008595,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009798,GO:0009880,GO:0009888,GO:0009892,GO:0009948,GO:0009952,GO:0009987,GO:0009994,GO:0010468,GO:0010605,GO:0010608,GO:0010629,GO:0010927,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019439,GO:0019953,GO:0021700,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0030154,GO:0030424,GO:0030425,GO:0030554,GO:0030703,GO:0030707,GO:0030855,GO:0031023,GO:0031047,GO:0032259,GO:0032392,GO:0032501,GO:0032502,GO:0032504,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032989,GO:0032991,GO:0033036,GO:0034584,GO:0034587,GO:0034641,GO:0034655,GO:0034660,GO:0035194,GO:0035282,GO:0035639,GO:0035770,GO:0036094,GO:0036464,GO:0036477,GO:0040029,GO:0042623,GO:0042995,GO:0043005,GO:0043025,GO:0043046,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043186,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044297,GO:0044424,GO:0044444,GO:0044463,GO:0044464,GO:0044703,GO:0044728,GO:0045202,GO:0045495,GO:0045786,GO:0045787,GO:0046483,GO:0046700,GO:0046843,GO:0046872,GO:0048232,GO:0048285,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048646,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050877,GO:0050890,GO:0051179,GO:0051276,GO:0051321,GO:0051704,GO:0051726,GO:0060255,GO:0060293,GO:0060429,GO:0061061,GO:0061982,GO:0065007,GO:0070035,GO:0070725,GO:0071103,GO:0071546,GO:0071704,GO:0071840,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097367,GO:0097447,GO:0097458,GO:0120025,GO:0120038,GO:0140013,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901976,GO:1901977,GO:1903046,GO:1990904,GO:2000001,GO:2000002,GO:2001020,GO:2001021 3.6.4.13 ko:K13983,ko:K18422,ko:K18432 - - - - ko00000,ko01000,ko03019,ko03036 - - - AAA_11,AAA_12,S1-like k59_304314_1 378806.STAUR_5279 3.17e-49 166.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42QU3@68525|delta/epsilon subdivisions,2WMTF@28221|Deltaproteobacteria,2YV2S@29|Myxococcales 28221|Deltaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_837638_1 1286631.X805_31170 8.82e-39 141.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,1KJPD@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA selU - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_375094_1 1122951.ATUE01000009_gene457 1.93e-90 268.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,3NK7Y@468|Moraxellaceae 1236|Gammaproteobacteria E Acetolactate synthase small ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086 ACT,ACT_5,ALS_ss_C k59_226642_1 497964.CfE428DRAFT_2643 3.3e-54 174.0 COG0059@1|root,COG0059@2|Bacteria,46SI2@74201|Verrucomicrobia 74201|Verrucomicrobia EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_729593_1 614083.AWQR01000005_gene981 1.63e-28 113.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_729593_2 391735.Veis_3002 5.51e-40 136.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria,4AA0S@80864|Comamonadaceae 28216|Betaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_454543_1 232721.Ajs_3149 5.84e-98 306.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,4AA2T@80864|Comamonadaceae 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_669007_2 1265502.KB905972_gene1349 1.43e-65 199.0 COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,2VTY4@28216|Betaproteobacteria,4AFP7@80864|Comamonadaceae 28216|Betaproteobacteria K Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - RelE k59_669007_3 946483.Cenrod_0077 7.05e-53 167.0 COG2944@1|root,COG2944@2|Bacteria,1N5H0@1224|Proteobacteria,2VW7F@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3 k59_407970_1 159087.Daro_3186 2.05e-97 290.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,2KV4C@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_226650_1 1000565.METUNv1_01597 2.94e-84 268.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,2KUNW@206389|Rhodocyclales 206389|Rhodocyclales O Cytochrome c ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_87237_2 313624.NSP_25570 7.85e-87 262.0 COG2189@1|root,COG2189@2|Bacteria,1G2XK@1117|Cyanobacteria,1HU8N@1161|Nostocales 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_692817_1 743720.Psefu_0160 1.65e-24 94.4 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1RX2G@1236|Gammaproteobacteria,1YYY9@136845|Pseudomonas putida group 1236|Gammaproteobacteria T Response regulator receiver protein - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_692817_2 1458275.AZ34_12925 1.23e-09 58.2 COG1366@1|root,COG1366@2|Bacteria,1N8B6@1224|Proteobacteria,2VWCQ@28216|Betaproteobacteria,4AF9B@80864|Comamonadaceae 28216|Betaproteobacteria T STAS domain - - - - - - - - - - - - STAS_2 k59_692817_3 580332.Slit_1588 2.05e-05 47.4 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,44W69@713636|Nitrosomonadales 28216|Betaproteobacteria T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_203900_1 443143.GM18_2280 9.11e-51 182.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales 28221|Deltaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg k59_669050_1 1144319.PMI16_00498 2.79e-43 147.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria 28216|Betaproteobacteria E Abc transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_669050_2 1144319.PMI16_00497 4.15e-41 141.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,473EN@75682|Oxalobacteraceae 28216|Betaproteobacteria E branched-chain amino acid - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C k59_618419_2 391735.Veis_0593 2.98e-52 167.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,4ADK4@80864|Comamonadaceae 28216|Betaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_692847_2 1045855.DSC_01105 3.94e-07 53.5 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1X3CT@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_763171_1 1430440.MGMSRv2_1983 1.09e-53 174.0 2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1120686_1 1117958.PE143B_0129730 2.55e-76 243.0 2F08J@1|root,33TBY@2|Bacteria,1NTKB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1120686_2 1117958.PE143B_0129725 1.56e-17 80.9 28YWR@1|root,2ZKPV@2|Bacteria,1P81T@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_87276_1 395495.Lcho_2965 2.69e-91 285.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VIVH@28216|Betaproteobacteria,1KJKC@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Creatinase/Prolidase N-terminal domain pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k59_763183_1 742817.HMPREF9449_02416 6.57e-73 227.0 COG1587@1|root,COG1587@2|Bacteria,4NEQ3@976|Bacteroidetes,2FMX9@200643|Bacteroidia,22W2D@171551|Porphyromonadaceae 976|Bacteroidetes H Uroporphyrinogen-III synthase hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_729655_1 666681.M301_1495 8.86e-80 268.0 COG2202@1|root,COG3614@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,HAMP,PAS_3,PAS_9,Phosphonate-bd k59_346936_1 1216967.L100_16590 1.78e-43 152.0 COG0412@1|root,COG0412@2|Bacteria,4NKMA@976|Bacteroidetes,1I0KZ@117743|Flavobacteriia,34QAI@308865|Elizabethkingia 976|Bacteroidetes M Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_454640_1 204773.HEAR3348 1.05e-50 165.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_729674_1 338969.Rfer_1328 7.07e-110 327.0 COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,4ACES@80864|Comamonadaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine - - 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_803035_1 62928.azo1280 8.23e-99 293.0 COG0543@1|root,COG0543@2|Bacteria,1QTSK@1224|Proteobacteria,2VH0M@28216|Betaproteobacteria,2KUPK@206389|Rhodocyclales 206389|Rhodocyclales CH oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_908635_1 375286.mma_3639 1.8e-100 309.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,472AG@75682|Oxalobacteraceae 28216|Betaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_525807_2 1137799.GZ78_20225 2.44e-09 61.6 COG1040@1|root,COG1040@2|Bacteria,1REX9@1224|Proteobacteria,1S568@1236|Gammaproteobacteria,1XKVW@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_122927_1 159087.Daro_0210 4.22e-17 80.1 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,2KV8N@206389|Rhodocyclales 206389|Rhodocyclales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_122927_2 640081.Dsui_1186 5.77e-18 83.2 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KU7U@206389|Rhodocyclales 206389|Rhodocyclales M penicillin-binding protein 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1091635_1 159087.Daro_1964 3.85e-120 351.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VK57@28216|Betaproteobacteria,2KV84@206389|Rhodocyclales 206389|Rhodocyclales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroA - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_525810_1 261292.Nit79A3_2187 1.6e-52 177.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,372KU@32003|Nitrosomonadales 28216|Betaproteobacteria S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase k59_304433_1 1538295.JY96_10795 2.29e-88 275.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,1KIZE@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_729682_1 395495.Lcho_4146 1.32e-09 56.6 2EPCF@1|root,33GZ4@2|Bacteria,1NMQU@1224|Proteobacteria,2VY4J@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_159195_1 1458275.AZ34_14675 1.78e-24 105.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,2VQKM@28216|Betaproteobacteria,4AEPD@80864|Comamonadaceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_375205_1 76114.ebA220 3.08e-200 568.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VICV@28216|Betaproteobacteria,2KUY2@206389|Rhodocyclales 206389|Rhodocyclales L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_1091643_1 375286.mma_2853 1.17e-56 193.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,4739P@75682|Oxalobacteraceae 28216|Betaproteobacteria S Peptidase family M48 yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_304463_1 420662.Mpe_A1278 7.32e-108 325.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1KJ2K@119065|unclassified Burkholderiales 28216|Betaproteobacteria T TIGRFAM phosphate regulon sensor kinase PhoR phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_481105_1 1356852.N008_16435 1.3e-26 110.0 2AFYA@1|root,31622@2|Bacteria,4P4XX@976|Bacteroidetes,47VB7@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1571) - - - - - - - - - - - - DUF1571,LysM k59_122960_1 700598.Niako_2630 5.92e-56 177.0 COG4430@1|root,COG4430@2|Bacteria,4NQAJ@976|Bacteroidetes,1IUMF@117747|Sphingobacteriia 976|Bacteroidetes S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA k59_349307_1 929556.Solca_3199 3.33e-14 72.0 COG0573@1|root,COG0573@2|Bacteria,4NFDD@976|Bacteroidetes,1IPVZ@117747|Sphingobacteriia 976|Bacteroidetes P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_349307_2 357808.RoseRS_4155 0.000277 46.6 COG0581@1|root,COG0581@2|Bacteria,2G6BI@200795|Chloroflexi,374ZR@32061|Chloroflexia 32061|Chloroflexia P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_141891_1 999541.bgla_1g06000 1.14e-96 286.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,1JZV5@119060|Burkholderiaceae 28216|Betaproteobacteria E ABC transporter gltL - 3.6.3.21 ko:K02028,ko:K10004 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - ABC_tran k59_780451_2 1235790.C805_02750 1.13e-39 142.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,25VRJ@186806|Eubacteriaceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region appF - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_749229_1 338969.Rfer_1304 6.6e-13 67.4 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2VRTK@28216|Betaproteobacteria,4ACHD@80864|Comamonadaceae 28216|Betaproteobacteria D Belongs to the ParA family fleN - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA k59_749229_2 1276756.AUEX01000025_gene2051 2.01e-127 368.0 2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2WGPR@28216|Betaproteobacteria,4A9V4@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - DUF429 k59_70705_1 1121033.AUCF01000006_gene4364 1.31e-26 103.0 COG1539@1|root,COG1539@2|Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB GO:0008150,GO:0040007 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 ko:K00796,ko:K00950,ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503,R03504,R11037,R11073 RC00002,RC00017,RC00121,RC00721,RC00842,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_1105035_1 1123255.JHYS01000001_gene2007 1.33e-93 294.0 COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,2VNQ8@28216|Betaproteobacteria,4AATM@80864|Comamonadaceae 28216|Betaproteobacteria M Glycosyl transferase 4-like domain wbpZ - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_925482_1 1415778.JQMM01000001_gene2030 1.71e-14 79.0 COG0642@1|root,COG5001@1|root,COG2205@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - DUF2222,EAL,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_780547_1 1485544.JQKP01000013_gene1802 1.67e-06 47.4 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VSQE@28216|Betaproteobacteria,44VW0@713636|Nitrosomonadales 28216|Betaproteobacteria C TIGRFAM ferredoxin, 2Fe-2S type, ISC system fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_780547_2 204773.HEAR2235 2.09e-50 176.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,472BD@75682|Oxalobacteraceae 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_1105069_1 1506994.JNLQ01000002_gene3210 4.7e-20 92.0 COG4209@1|root,COG4209@2|Bacteria,1TSTC@1239|Firmicutes,24AFM@186801|Clostridia,4BXZE@830|Butyrivibrio 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_780563_1 153721.MYP_1518 1.06e-88 287.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47M4G@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1139542_1 694427.Palpr_2029 7.06e-45 167.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,2FNEV@200643|Bacteroidia,22WBN@171551|Porphyromonadaceae 976|Bacteroidetes M esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_70772_1 28377.ENSACAP00000004844 1.44e-20 96.7 COG1657@1|root,KOG0497@2759|Eukaryota,38CDP@33154|Opisthokonta,3BHUI@33208|Metazoa,3D1EA@33213|Bilateria,486ER@7711|Chordata,4959J@7742|Vertebrata 33208|Metazoa I oxidosqualene cyclase activity LSS GO:0000250,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0006066,GO:0006629,GO:0006694,GO:0006695,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009889,GO:0012505,GO:0016020,GO:0016125,GO:0016126,GO:0016853,GO:0016866,GO:0019216,GO:0019218,GO:0019222,GO:0031559,GO:0031647,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044238,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045540,GO:0046165,GO:0046890,GO:0050789,GO:0050810,GO:0062012,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090181,GO:0098827,GO:0106118,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1902930 5.4.99.7 ko:K01852 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R03199 RC00874 ko00000,ko00001,ko00002,ko01000 - - - Prenyltrans,SQHop_cyclase_C,SQHop_cyclase_N k59_957774_2 382464.ABSI01000012_gene2216 2.45e-37 136.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,46XK4@74201|Verrucomicrobia,2IW45@203494|Verrucomicrobiae 203494|Verrucomicrobiae L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_142074_1 983545.Glaag_0108 2.75e-115 338.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RZDH@1236|Gammaproteobacteria,469MJ@72275|Alteromonadaceae 1236|Gammaproteobacteria S AAA domain (Cdc48 subfamily) - - - - - - - - - - - - AAA_5 k59_70827_1 1000565.METUNv1_03782 2.78e-269 743.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,2KVUX@206389|Rhodocyclales 206389|Rhodocyclales M COG2148 Sugar transferases involved in lipopolysaccharide synthesis sthA - - - - - - - - - - - Bac_transf k59_632322_1 244582.JQAK01000022_gene652 3.18e-18 80.5 2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_600947_1 614083.AWQR01000031_gene2656 1.18e-98 292.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,4ABUX@80864|Comamonadaceae 28216|Betaproteobacteria F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation ydiA - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_425387_1 351160.RCIX576 7.81e-08 60.5 COG0642@1|root,COG2202@1|root,arCOG06940@1|root,arCOG06192@2157|Archaea,arCOG06918@2157|Archaea,arCOG06940@2157|Archaea,2Y7UZ@28890|Euryarchaeota,2NBMV@224756|Methanomicrobia 224756|Methanomicrobia T SMART PAS domain containing protein - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg k59_1139660_1 1408418.JNJH01000036_gene518 2.12e-20 94.0 COG1252@1|root,COG1252@2|Bacteria,1QUKT@1224|Proteobacteria,2TW32@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1252 NADH dehydrogenase FAD-containing subunit - - - - - - - - - - - - Pyr_redox_2 k59_142175_2 247633.GP2143_08414 2.25e-43 145.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1J5D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1525 DCD,dUTPase k59_996996_1 1437448.AZRT01000153_gene326 6.37e-68 210.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs MA20_17490 - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_820276_1 929703.KE386491_gene2417 3.92e-26 104.0 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,47MJ5@768503|Cytophagia 976|Bacteroidetes T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07657,ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1105288_1 1443125.Z962_06475 6.9e-46 152.0 COG1669@1|root,COG1669@2|Bacteria,1V6R7@1239|Firmicutes,25DJJ@186801|Clostridia,36M3J@31979|Clostridiaceae 186801|Clostridia S Nucleotidyltransferase substrate binding protein like - - - - - - - - - - - - NTase_sub_bind k59_142217_1 1000565.METUNv1_02632 8.85e-18 82.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,2VHVZ@28216|Betaproteobacteria,2KV50@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar biosynthesis regulator FlhF flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_142217_2 1000565.METUNv1_02633 5.13e-142 408.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2VRTK@28216|Betaproteobacteria,2KUF4@206389|Rhodocyclales 206389|Rhodocyclales D Belongs to the ParA family - - - ko:K04562 - - - - ko00000,ko02035 - - - CbiA k59_34597_1 748247.AZKH_0336 7.18e-43 149.0 COG0457@1|root,COG0457@2|Bacteria,1N986@1224|Proteobacteria,2VWWW@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_957921_1 83406.HDN1F_21820 2.49e-83 260.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1139732_1 1198452.Jab_2c07810 2.81e-186 526.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,4735V@75682|Oxalobacteraceae 28216|Betaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_957929_1 397945.Aave_4385 1.55e-118 345.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2VIU6@28216|Betaproteobacteria,4AC06@80864|Comamonadaceae 28216|Betaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_1139748_1 1480694.DC28_14250 4.96e-54 171.0 COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes 203691|Spirochaetes J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1139748_2 1191523.MROS_0192 4.26e-22 88.6 COG0099@1|root,COG0099@2|Bacteria 2|Bacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_464355_1 987059.RBXJA2T_11897 6.77e-110 330.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,1KJF3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Alkyl hydroperoxide reductase ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_285894_1 1198452.Jab_1c01440 3.62e-85 268.0 COG1649@1|root,COG1649@2|Bacteria,1N99Y@1224|Proteobacteria,2VNDK@28216|Betaproteobacteria,476DC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Glycosyl hydrolase-like 10 - - - - - - - - - - - - GHL10 k59_821229_1 1000565.METUNv1_00101 1.51e-265 743.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_571308_1 420662.Mpe_A3660 6.29e-121 363.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VM62@28216|Betaproteobacteria,1KIUI@119065|unclassified Burkholderiales 1224|Proteobacteria G PFAM Pyrrolo-quinoline quinone - - 1.1.2.8,1.1.5.11,1.1.5.2,1.1.9.1 ko:K00114,ko:K00117,ko:K17760,ko:K20937 ko00010,ko00030,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285,R06620 RC00066,RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_642931_1 1000565.METUNv1_01027 1.55e-143 412.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,2KV1J@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_464359_1 1231391.AMZF01000017_gene175 4.34e-35 130.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,3T28D@506|Alcaligenaceae 28216|Betaproteobacteria U MotA TolQ ExbB proton channel family protein exbB1 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_464359_2 1101195.Meth11DRAFT_0692 1.41e-36 129.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,2KN0J@206350|Nitrosomonadales 206350|Nitrosomonadales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1106764_1 1408433.JHXV01000020_gene3535 2.67e-33 132.0 COG1572@1|root,COG3266@1|root,COG1572@2|Bacteria,COG3266@2|Bacteria,4NQBS@976|Bacteroidetes,1I3X2@117743|Flavobacteriia 976|Bacteroidetes S FG-GAP repeat - - - - - - - - - - - - FG-GAP_2 k59_606949_1 1000565.METUNv1_01060 4.21e-128 383.0 COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,2VK59@28216|Betaproteobacteria,2KV8J@206389|Rhodocyclales 206389|Rhodocyclales T 5TM C-terminal transporter carbon starvation CstA - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_285899_1 640081.Dsui_0561 2.83e-20 90.1 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,2VMCH@28216|Betaproteobacteria,2KUFB@206389|Rhodocyclales 206389|Rhodocyclales H TOBE domain - - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE k59_285899_2 1101191.KI912577_gene2305 9.71e-41 148.0 COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,1JT1F@119045|Methylobacteriaceae 28211|Alphaproteobacteria Q TIGRFAM esterase, PHB depolymerase family - - - - - - - - - - - - Esterase_phd k59_535640_1 1144310.PMI07_001618 3.02e-40 144.0 COG1172@1|root,COG1172@2|Bacteria,1MUM6@1224|Proteobacteria,2TUE1@28211|Alphaproteobacteria,4BA3B@82115|Rhizobiaceae 28211|Alphaproteobacteria G Belongs to the binding-protein-dependent transport system permease family ytfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_535640_2 439375.Oant_1415 1.81e-19 86.7 COG1172@1|root,COG1172@2|Bacteria,1MW9Z@1224|Proteobacteria,2TTCG@28211|Alphaproteobacteria,1J3VS@118882|Brucellaceae 28211|Alphaproteobacteria G Branched-chain amino acid transport system / permease component yjfF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_785625_1 1000565.METUNv1_03785 2.41e-68 234.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria,2KV97@206389|Rhodocyclales 206389|Rhodocyclales NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_785626_1 1000565.METUNv1_03302 3.91e-40 132.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,2KXDH@206389|Rhodocyclales 206389|Rhodocyclales C Rubredoxin - - - - - - - - - - - - Rubredoxin k59_785626_2 1000565.METUNv1_03301 1.11e-30 110.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KWB2@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain pilG - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_214419_1 1000565.METUNv1_02654 8.03e-213 595.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,2KV5D@206389|Rhodocyclales 206389|Rhodocyclales EGP COG0477 Permeases of the major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_214419_2 1000565.METUNv1_02655 2.17e-51 174.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,2KVD8@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_500149_2 1458275.AZ34_06555 8.51e-50 159.0 COG3514@1|root,COG3514@2|Bacteria,1N7UF@1224|Proteobacteria,2VW3X@28216|Betaproteobacteria,4AFRM@80864|Comamonadaceae 28216|Betaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_500149_3 1458427.BAWN01000024_gene1515 3.14e-40 137.0 COG2929@1|root,COG2929@2|Bacteria,1PUHA@1224|Proteobacteria,2VVAK@28216|Betaproteobacteria,4AJM7@80864|Comamonadaceae 28216|Betaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_1106775_1 948106.AWZT01000033_gene1669 1.29e-56 192.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1JZWE@119060|Burkholderiaceae 28216|Betaproteobacteria NT Cache type 2 domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH,sCache_2 k59_285915_1 761193.Runsl_2487 1.48e-61 213.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47NMF@768503|Cytophagia 976|Bacteroidetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_214420_1 1000565.METUNv1_00203 1.31e-51 173.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,2KUQC@206389|Rhodocyclales 206389|Rhodocyclales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_214420_2 1000565.METUNv1_00202 3.74e-61 197.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,2KUDX@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_321710_1 358220.C380_09680 8.55e-96 285.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,4AA8R@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_892646_1 1000565.METUNv1_01021 1.08e-129 380.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW0@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DEAD box helicase family rhlE1 - - - - - - - - - - - DEAD,Helicase_C k59_36080_1 1000565.METUNv1_02636 3.05e-35 129.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2VKC4@28216|Betaproteobacteria,2KV6P@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_678428_1 864051.BurJ1DRAFT_0834 2.58e-38 132.0 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VX02@28216|Betaproteobacteria,1KMH9@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_678428_2 1390370.O203_05320 9.95e-08 50.4 COG0599@1|root,COG0599@2|Bacteria,1RFQD@1224|Proteobacteria,1S451@1236|Gammaproteobacteria,1YI77@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_535660_1 1123354.AUDR01000014_gene850 1.21e-51 167.0 COG1487@1|root,COG1487@2|Bacteria,1RJDP@1224|Proteobacteria,2WGAS@28216|Betaproteobacteria 28216|Betaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_178959_2 1000565.METUNv1_03373 9.87e-267 735.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,2KUDB@206389|Rhodocyclales 206389|Rhodocyclales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_321725_1 1502852.FG94_02409 1.77e-09 59.7 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VIE8@28216|Betaproteobacteria,4762F@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase family M3 - - 3.4.15.5 ko:K01284 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_892658_2 243924.LT42_19535 8.71e-10 60.8 COG4695@1|root,COG4695@2|Bacteria,1MWA5@1224|Proteobacteria,1RPXY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein Q - - - - - - - - - - - Phage_portal k59_856878_1 1122927.KB895417_gene3179 2.32e-19 91.7 COG1216@1|root,COG1216@2|Bacteria,1V4TU@1239|Firmicutes 1239|Firmicutes S Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_678429_1 1000565.METUNv1_03764 1.04e-176 504.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,2KVCF@206389|Rhodocyclales 206389|Rhodocyclales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_678429_2 1000565.METUNv1_03765 1.85e-43 152.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VJVY@28216|Betaproteobacteria,2KY04@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_606966_1 1278309.KB907101_gene502 3.63e-46 162.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1XJ5Y@135619|Oceanospirillales 135619|Oceanospirillales S hydrolase of the alpha beta-hydrolase fold - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_250231_1 237609.PSAKL28_04230 1.4e-53 191.0 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 k59_428795_1 84531.JMTZ01000024_gene4045 1.32e-74 229.0 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,1S3U0@1236|Gammaproteobacteria,1X6QC@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_428795_2 864051.BurJ1DRAFT_1011 1.89e-55 179.0 COG0457@1|root,COG0457@2|Bacteria,1RC44@1224|Proteobacteria,2VUVD@28216|Betaproteobacteria,1KMBW@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_428795_3 1485544.JQKP01000001_gene1009 2.52e-08 51.2 COG3411@1|root,COG3411@2|Bacteria,1Q5IQ@1224|Proteobacteria,2WCSS@28216|Betaproteobacteria,44WM1@713636|Nitrosomonadales 28216|Betaproteobacteria C Ferredoxin - - - - - - - - - - - - - k59_1071279_1 1095769.CAHF01000014_gene2878 1.58e-51 179.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,472RM@75682|Oxalobacteraceae 28216|Betaproteobacteria T Sigma-54 interaction domain pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_321729_2 1000565.METUNv1_01867 4.52e-110 319.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2VQAQ@28216|Betaproteobacteria,2KW2Q@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_221616_1 1000565.METUNv1_00452 1.11e-122 368.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KY7E@206389|Rhodocyclales 206389|Rhodocyclales K GAF domain - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_1010484_1 1000565.METUNv1_00676 1.06e-86 267.0 COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,2VN7N@28216|Betaproteobacteria,2KUR6@206389|Rhodocyclales 206389|Rhodocyclales T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg k59_544529_1 1504672.669785435 5.24e-70 229.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_116709_1 1123504.JQKD01000026_gene4292 1.51e-75 243.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4AA1I@80864|Comamonadaceae 28216|Betaproteobacteria NU TIGRFAM type IV-A pilus assembly ATPase PilB pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_866298_1 700598.Niako_6024 4.31e-47 152.0 COG0776@1|root,COG0776@2|Bacteria,4NSK6@976|Bacteroidetes,1IYVW@117747|Sphingobacteriia 976|Bacteroidetes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_10059_1 859657.RPSI07_3221 7.3e-11 71.6 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria,1KH59@119060|Burkholderiaceae 28216|Betaproteobacteria M Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - RHS,RHS_repeat k59_445159_1 1132441.KI519455_gene3568 6.55e-07 52.8 COG2199@1|root,COG3706@2|Bacteria,2ISZA@201174|Actinobacteria 201174|Actinobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_796599_2 614083.AWQR01000003_gene2920 9.41e-19 84.7 COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,2VNVN@28216|Betaproteobacteria,4ADMC@80864|Comamonadaceae 28216|Betaproteobacteria D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C,MinC_N k59_613760_1 926549.KI421517_gene465 3.01e-81 254.0 COG0044@1|root,COG0044@2|Bacteria,4NE3T@976|Bacteroidetes,47JPG@768503|Cytophagia 976|Bacteroidetes F TIGRFAM dihydroorotase, multifunctional complex type pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_544549_2 614083.AWQR01000005_gene1009 4.15e-44 152.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,4AAT1@80864|Comamonadaceae 28216|Betaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1087580_1 987059.RBXJA2T_03973 6.09e-29 104.0 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,1KMJF@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_1087580_2 1000565.METUNv1_03876 2.83e-06 48.5 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,2KVAG@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases nnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1010508_1 1000565.METUNv1_03781 2.33e-115 344.0 2DBCU@1|root,2Z8FP@2|Bacteria,1R5HD@1224|Proteobacteria,2VPI4@28216|Betaproteobacteria,2KWDA@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_10084_1 1198452.Jab_2c15470 3.33e-24 94.4 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,2VWEY@28216|Betaproteobacteria,474I1@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 k59_10084_2 1349767.GJA_1627 6.4e-54 175.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,472QR@75682|Oxalobacteraceae 28216|Betaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_544564_1 1000565.METUNv1_03311 1.68e-76 233.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,2KWSF@206389|Rhodocyclales 206389|Rhodocyclales O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_544564_2 1000565.METUNv1_03310 1.05e-113 333.0 COG4221@1|root,COG4221@2|Bacteria,1QTVZ@1224|Proteobacteria,2WGPF@28216|Betaproteobacteria,2KZNP@206389|Rhodocyclales 206389|Rhodocyclales S KR domain - - - - - - - - - - - - adh_short k59_659529_1 1123393.KB891316_gene1605 1.37e-36 128.0 COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,1KT32@119069|Hydrogenophilales 119069|Hydrogenophilales O Hsp20/alpha crystallin family - - - - - - - - - - - - HSP20 k59_659529_2 1089551.KE386572_gene54 1.02e-11 63.9 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_116749_1 1000565.METUNv1_02025 6.25e-85 258.0 COG3221@1|root,COG3221@2|Bacteria,1N5FI@1224|Proteobacteria,2VTXP@28216|Betaproteobacteria,2KWYV@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - - - - - - - - - - Phosphonate-bd k59_686983_1 983917.RGE_29120 7.11e-50 169.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1KJ43@119065|unclassified Burkholderiales 28216|Betaproteobacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1010516_2 1000565.METUNv1_02431 7.19e-56 181.0 2EF3F@1|root,338WI@2|Bacteria,1N91Z@1224|Proteobacteria,2W4MP@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1115017_1 864073.HFRIS_005983 6.78e-104 312.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHD2@28216|Betaproteobacteria,4761K@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP of the major facilitator superfamily citA - - - - - - - - - - - MFS_1,Sugar_tr k59_1045156_1 1122605.KB893637_gene3103 3.52e-29 111.0 COG0791@1|root,COG0791@2|Bacteria,4NMT8@976|Bacteroidetes,1IRY7@117747|Sphingobacteriia 976|Bacteroidetes M Nlp p60 protein - - 3.4.17.13 ko:K13694,ko:K13695 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 k59_1045156_2 700598.Niako_0366 1.74e-47 158.0 COG0107@1|root,COG0107@2|Bacteria,4NE16@976|Bacteroidetes,1INX3@117747|Sphingobacteriia 976|Bacteroidetes E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_297607_1 1230338.MOMA_06021 7.69e-23 95.9 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S28H@1236|Gammaproteobacteria,3NJTE@468|Moraxellaceae 1236|Gammaproteobacteria M Transglycosylase SLT domain yjbJ - - - - - - - - - - - SLT k59_297610_1 497964.CfE428DRAFT_4704 1.87e-12 69.7 COG2825@1|root,COG2825@2|Bacteria,46T22@74201|Verrucomicrobia 74201|Verrucomicrobia M PFAM outer membrane chaperone Skp (OmpH) hlpA - - ko:K06142 - - - - ko00000 - - - OmpH k59_796670_1 211586.SO_1081 3.84e-110 329.0 28M8W@1|root,2ZAMX@2|Bacteria,1N3D9@1224|Proteobacteria,1SAIK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4062) - - - - - - - - - - - - DUF4062 k59_1115030_2 1000565.METUNv1_00796 2.45e-72 224.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria,2KVHJ@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_46577_1 1000565.METUNv1_02986 5.44e-154 443.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,2KU6W@206389|Rhodocyclales 206389|Rhodocyclales J ribonuclease, Rne Rng family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_116792_1 1123401.JHYQ01000003_gene2070 5.07e-100 331.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,1RSEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF1800 k59_445303_2 614083.AWQR01000019_gene3786 3.55e-74 224.0 COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,4AEG5@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_117959_1 420662.Mpe_A3753 3.33e-112 333.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,1KNUJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria L 6-O-methylguanine DNA methyltransferase, DNA binding domain ada GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,HTH_AraC,Methyltransf_1N k59_1116285_1 614083.AWQR01000029_gene2171 1.36e-58 193.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,4AAIA@80864|Comamonadaceae 28216|Betaproteobacteria CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 ubiF - - - - - - - - - - - FAD_binding_3,SE k59_518063_1 1268622.AVS7_03652 2.45e-45 153.0 COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,2VISC@28216|Betaproteobacteria,4AA36@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar basal body rod protein flgF - - ko:K02391 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_518063_2 1268622.AVS7_03653 8.47e-28 110.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,4AATG@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar basal body rod protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_518067_1 338969.Rfer_2589 3.23e-80 249.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VJ1E@28216|Betaproteobacteria,4ACV2@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_688098_1 1198452.Jab_1c21010 6.54e-40 138.0 COG4967@1|root,COG4967@2|Bacteria,1NFJJ@1224|Proteobacteria,2VWE7@28216|Betaproteobacteria,474V7@75682|Oxalobacteraceae 28216|Betaproteobacteria NU type IV pilus modification protein PilV pilV - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_154251_1 1000565.METUNv1_03840 5.08e-99 296.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,2KUPR@206389|Rhodocyclales 206389|Rhodocyclales T alginate biosynthesis protein AlgZ FimS - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_154251_2 1000565.METUNv1_03841 8.43e-33 120.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,2M03Q@206389|Rhodocyclales 206389|Rhodocyclales K Alginate biosynthesis regulatory protein AlgR - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_117979_1 614083.AWQR01000013_gene1665 1.53e-119 348.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,4AAKA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_83016_1 685778.AORL01000019_gene1837 7.14e-95 305.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2KCZ7@204457|Sphingomonadales 204457|Sphingomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_833363_1 1122951.ATUE01000005_gene2003 1.34e-20 84.7 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0235 family yggU - - ko:K09131 - - - - ko00000 - - - DUF167 k59_833363_2 1283300.ATXB01000001_gene2151 2.96e-17 80.9 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1XF20@135618|Methylococcales 135618|Methylococcales S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_867764_1 1000565.METUNv1_00286 3.21e-108 324.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VH58@28216|Betaproteobacteria,2KV8Z@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrom_C,Cytochrome_CBB3 k59_476006_1 305700.B447_03333 9.72e-21 94.0 COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VK4V@28216|Betaproteobacteria,2KVNZ@206389|Rhodocyclales 206389|Rhodocyclales K AraC family - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_262322_1 1415778.JQMM01000001_gene1098 2.18e-74 237.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0303 Molybdopterin biosynthesis enzyme moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1046146_1 1434929.X946_2713 5.62e-61 206.0 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,2W139@28216|Betaproteobacteria,1KEAH@119060|Burkholderiaceae 28216|Betaproteobacteria V Carboxypeptidase regulatory-like domain - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - CarboxypepD_reg k59_1011611_1 580332.Slit_1455 1.96e-60 209.0 COG0834@1|root,COG2203@1|root,COG5001@1|root,COG0834@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44WBU@713636|Nitrosomonadales 28216|Betaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC and GAF sensor(S) - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9,SBP_bac_3 k59_447282_1 1198452.Jab_1c23690 9.7e-53 174.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2VQ1R@28216|Betaproteobacteria,474C6@75682|Oxalobacteraceae 28216|Betaproteobacteria KT response regulator baeR - - ko:K07664 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_518117_1 1123073.KB899245_gene133 6.48e-20 84.7 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales 135614|Xanthomonadales S adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_518117_2 1121035.AUCH01000015_gene2580 5.25e-36 131.0 COG1639@1|root,COG1639@2|Bacteria,1R4P9@1224|Proteobacteria,2VPPP@28216|Betaproteobacteria,2KVX9@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_725068_1 156889.Mmc1_1716 8.25e-95 287.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_725068_5 375286.mma_2199 1.52e-61 199.0 2DQXG@1|root,3396G@2|Bacteria,1NE3G@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_725068_6 375286.mma_2198 2.04e-188 544.0 28QU5@1|root,2ZD9H@2|Bacteria,1RAU8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_725068_8 375286.mma_2196 3.14e-51 177.0 2C22H@1|root,332AB@2|Bacteria,1NBGI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - Peptidase_S74 k59_725068_9 373126.Q2A0B1_9VIRU 2.26e-18 95.1 4QB1J@10239|Viruses 10239|Viruses S Pfam:Inj_translocase - GO:0006810,GO:0008150,GO:0016032,GO:0019058,GO:0030260,GO:0039678,GO:0044403,GO:0044409,GO:0044419,GO:0044766,GO:0046718,GO:0046794,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0099002,GO:1902579 - - - - - - - - - - - k59_725068_10 1144325.PMI22_00480 5.58e-128 397.0 COG0741@1|root,COG0741@2|Bacteria,1R43Q@1224|Proteobacteria,1RPI2@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - PG_binding_1,SLT k59_725068_11 1040982.AXAL01000015_gene2402 9.16e-09 64.7 2AMF5@1|root,31CAN@2|Bacteria,1P9QS@1224|Proteobacteria,2UYFM@28211|Alphaproteobacteria,43QR1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_725068_14 470.IX87_22070 1.38e-18 82.8 296XV@1|root,2ZU6I@2|Bacteria,1P5NI@1224|Proteobacteria,1TMK8@1236|Gammaproteobacteria,3NNSJ@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_725068_15 1029823.AFIE01000004_gene1591 6.99e-44 148.0 2EBAW@1|root,335BJ@2|Bacteria,1N90V@1224|Proteobacteria,1TMK0@1236|Gammaproteobacteria,3NNS2@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_725068_16 204669.Acid345_3153 1.95e-40 139.0 2DMYE@1|root,32UDK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_725068_19 316274.Haur_4696 1.38e-08 63.5 COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,3754J@32061|Chloroflexia 32061|Chloroflexia L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_736490_1 1502851.FG93_00751 7.39e-24 107.0 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,2TSB7@28211|Alphaproteobacteria 28211|Alphaproteobacteria M TIGRFAM outer membrane autotransporter barrel domain - - - - - - - - - - - - Autotransporter,PATR k59_1096449_1 1121011.AUCB01000034_gene923 1.45e-49 163.0 COG2353@1|root,COG2353@2|Bacteria,4NNMD@976|Bacteroidetes,1I18S@117743|Flavobacteriia,23HZP@178469|Arenibacter 976|Bacteroidetes S YceI-like domain - - - - - - - - - - - - YceI k59_1096449_2 1296416.JACB01000055_gene3644 2.02e-09 57.8 COG1741@1|root,COG1741@2|Bacteria,4NGJ5@976|Bacteroidetes,1HYY2@117743|Flavobacteriia,2YHXX@290174|Aquimarina 976|Bacteroidetes S Pirin - - - ko:K06911 - - - - ko00000 - - - Pirin k59_130635_1 1121918.ARWE01000001_gene309 1.73e-45 158.0 COG1284@1|root,COG1284@2|Bacteria,1R59F@1224|Proteobacteria,42P6M@68525|delta/epsilon subdivisions,2WKCS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - DUF2179,YitT_membrane k59_1065250_1 118797.XP_007470646.1 1.9e-32 124.0 COG1866@1|root,2QQI5@2759|Eukaryota,38BH0@33154|Opisthokonta,3BXJ8@33208|Metazoa,3DF1I@33213|Bilateria 33208|Metazoa G Phosphoenolpyruvate carboxykinase - - - - - - - - - - - - PEPCK_ATP k59_1065250_2 351348.Maqu_2195 2.78e-34 125.0 COG0625@1|root,COG0625@2|Bacteria,1R7YC@1224|Proteobacteria,1S06X@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG0695 Glutaredoxin and related proteins - - - - - - - - - - - - GST_N_3 k59_915447_1 1195246.AGRI_02493 1.28e-59 198.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,464X8@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - iJN746.PP_2734 CMAS k59_95436_1 1123519.PSJM300_15875 1.41e-57 196.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1Z1M5@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_1024245_1 395495.Lcho_4368 1.23e-39 140.0 COG2865@1|root,COG2865@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - AlbA_2,DUF4062,PHP k59_1024245_2 1122221.JHVI01000008_gene2341 3.87e-107 327.0 COG0732@1|root,COG0732@2|Bacteria 2|Bacteria V type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_947910_1 1198452.Jab_2c11580 2.62e-93 281.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,47242@75682|Oxalobacteraceae 28216|Betaproteobacteria O C-terminal region of band_7 qmcA - - - - - - - - - - - Band_7,Band_7_C k59_1065293_1 1454004.AW11_02553 5.07e-13 66.6 COG1451@1|root,COG1451@2|Bacteria,1RDJ9@1224|Proteobacteria,2VR4I@28216|Betaproteobacteria 28216|Betaproteobacteria S Metal-dependent hydrolase ygjP - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1065293_2 1000565.METUNv1_03325 1.01e-75 229.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,2KW1F@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_947919_2 1000565.METUNv1_01569 9.27e-27 103.0 2BK8A@1|root,32ENA@2|Bacteria,1NQ7J@1224|Proteobacteria,2W50V@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_490037_1 477184.KYC_08050 4.32e-86 263.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,2VPF9@28216|Betaproteobacteria 28216|Betaproteobacteria S Short-chain dehydrogenase reductase (SDR) - - - - - - - - - - - - adh_short k59_985727_1 1125863.JAFN01000001_gene3262 6.72e-13 75.9 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_736533_1 296591.Bpro_0323 8.94e-76 229.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,4ADHJ@80864|Comamonadaceae 28216|Betaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_736533_3 1304883.KI912532_gene930 7.68e-18 81.3 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KVA0@206389|Rhodocyclales 206389|Rhodocyclales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_275379_1 1437824.BN940_08816 1.1e-26 114.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,3T1S3@506|Alcaligenaceae 28216|Betaproteobacteria O peptidyl-prolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_414933_1 358220.C380_08435 2.76e-105 311.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,4AARC@80864|Comamonadaceae 28216|Betaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_414934_1 1122951.ATUE01000005_gene2106 4.08e-51 169.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,3NIW8@468|Moraxellaceae 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_414935_1 398578.Daci_1860 3.92e-24 100.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,4ABWC@80864|Comamonadaceae 28216|Betaproteobacteria C Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit fdsB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S,SLBB k59_233196_1 1249627.D779_1404 6.99e-104 325.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WX2X@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9 k59_1127785_1 627192.SLG_26810 1.93e-60 205.0 COG0323@1|root,COG0323@2|Bacteria,1R3QS@1224|Proteobacteria,2TU3K@28211|Alphaproteobacteria,2KAEP@204457|Sphingomonadales 204457|Sphingomonadales L Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c_3 k59_95498_3 65093.PCC7418_1316 3.54e-05 46.2 COG2337@1|root,COG2337@2|Bacteria,1G8BS@1117|Cyanobacteria 1117|Cyanobacteria T PFAM PemK-like protein - - - ko:K07171 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin k59_166727_1 1504672.669787271 6.29e-35 125.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VHFT@28216|Betaproteobacteria,4AAV2@80864|Comamonadaceae 28216|Betaproteobacteria I TIGRFAM 3-oxoacid CoA-transferase, A subunit scoA - 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_166727_2 1268622.AVS7_04717 2.76e-39 135.0 COG2197@1|root,COG2197@2|Bacteria,1RAAY@1224|Proteobacteria,2VQ17@28216|Betaproteobacteria,4AAHC@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein LuxR - - - - - - - - - - - - GerE,PAS_9 k59_1065390_2 485917.Phep_2811 4.11e-43 148.0 29KG5@1|root,307DE@2|Bacteria,4NP5J@976|Bacteroidetes,1IS9U@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3826) - - - - - - - - - - - - DUF3826 k59_59920_1 700508.D174_21900 1.61e-09 61.2 COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria,23427@1762|Mycobacteriaceae 201174|Actinobacteria K transcriptional kdpE GO:0008150,GO:0040007 - ko:K02483,ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_385218_1 204773.HEAR1626 1.17e-08 55.8 COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2VI68@28216|Betaproteobacteria,472VQ@75682|Oxalobacteraceae 28216|Betaproteobacteria P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane kdpA - 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpA k59_314162_2 925409.KI911562_gene2299 6.97e-22 90.5 COG2316@1|root,COG2316@2|Bacteria,4NIAC@976|Bacteroidetes 976|Bacteroidetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_490153_1 983917.RGE_30750 1.57e-69 227.0 COG0412@1|root,COG0412@2|Bacteria,1Q876@1224|Proteobacteria,2WC50@28216|Betaproteobacteria,1KP8A@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_314192_1 522306.CAP2UW1_4384 2.77e-36 124.0 COG2026@1|root,COG2026@2|Bacteria,1QDRK@1224|Proteobacteria,2VYUW@28216|Betaproteobacteria 28216|Betaproteobacteria DJ ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_314192_2 1121033.AUCF01000015_gene1395 1.54e-14 72.0 COG1396@1|root,COG1396@2|Bacteria,1N7DN@1224|Proteobacteria,2UFS1@28211|Alphaproteobacteria,2JU8T@204441|Rhodospirillales 204441|Rhodospirillales K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_314192_3 3988.XP_002538887.1 5.83e-35 125.0 2D36K@1|root,2SQE2@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - HATPase_c,Response_reg k59_1024395_1 314265.R2601_26676 1.64e-06 57.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_1127886_1 340177.Cag_1242 1.28e-46 172.0 COG0689@1|root,COG0726@1|root,COG1785@1|root,COG2133@1|root,COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3898@1|root,COG4254@1|root,COG4932@1|root,COG0689@2|Bacteria,COG0726@2|Bacteria,COG1785@2|Bacteria,COG2133@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3898@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.1.3.1,3.4.24.40,3.6.1.66 ko:K00989,ko:K01077,ko:K01406,ko:K02428,ko:K20276,ko:K21430 ko00230,ko00730,ko00790,ko01100,ko01503,ko02020,ko02024,map00230,map00730,map00790,map01100,map01503,map02020,map02024 M00126 R00426,R00720,R01855,R02100,R02135,R02720,R03531,R04620 RC00002,RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko01002,ko03016,ko04147 - - - RNase_PH,RNase_PH_C k59_233286_1 395495.Lcho_0397 3.87e-15 77.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1KKD6@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_1065475_2 1000565.METUNv1_01198 1.04e-56 183.0 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,2VVPQ@28216|Betaproteobacteria,2KXGS@206389|Rhodocyclales 206389|Rhodocyclales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_700535_1 765911.Thivi_2142 8.69e-20 86.7 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1WYU2@135613|Chromatiales 135613|Chromatiales NU TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_700535_2 595537.Varpa_4212 3.58e-26 98.6 COG4628@1|root,COG4628@2|Bacteria,1N7DG@1224|Proteobacteria,2VW2Y@28216|Betaproteobacteria,4AEWN@80864|Comamonadaceae 28216|Betaproteobacteria S DNA-binding protein VF530 - - - - - - - - - - - - VF530 k59_769775_1 398578.Daci_0752 1e-79 251.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,4A9Q6@80864|Comamonadaceae 28216|Betaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_985880_1 338969.Rfer_3358 1.83e-18 82.4 COG1075@1|root,COG1075@2|Bacteria,1NB6J@1224|Proteobacteria,2VJTN@28216|Betaproteobacteria,4ABWK@80864|Comamonadaceae 28216|Betaproteobacteria S Alpha beta hydrolase fold lip - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_1024440_1 365044.Pnap_3519 2.29e-94 293.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,4A9RF@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_275541_2 358220.C380_08685 3.92e-15 72.0 COG1403@1|root,COG1403@2|Bacteria,1NI5K@1224|Proteobacteria,2VYZK@28216|Betaproteobacteria 28216|Betaproteobacteria V HNH nucleases - - - - - - - - - - - - - k59_985886_1 397945.Aave_4584 9.26e-21 86.3 COG1586@1|root,COG1586@2|Bacteria,1QWFT@1224|Proteobacteria,2VTEG@28216|Betaproteobacteria,4AJYS@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine - - 2.5.1.16,4.1.1.50 ko:K00797,ko:K01611 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R00178,R01920,R02869,R08359 RC00021,RC00053,RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_985886_2 887062.HGR_14514 3.05e-31 121.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,4AB6C@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_130861_1 929703.KE386491_gene3547 1.82e-67 210.0 COG0572@1|root,COG0572@2|Bacteria,4NEEC@976|Bacteroidetes,47P8Z@768503|Cytophagia 976|Bacteroidetes F Belongs to the uridine kinase family udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k59_985903_1 365046.Rta_05290 4.6e-12 64.3 COG0526@1|root,COG0526@2|Bacteria,1N8B0@1224|Proteobacteria,2VW5T@28216|Betaproteobacteria,4AEW1@80864|Comamonadaceae 28216|Betaproteobacteria CO PFAM Thioredoxin - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Thioredoxin k59_985903_2 1000565.METUNv1_01817 9.07e-13 65.1 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,2KWMU@206389|Rhodocyclales 206389|Rhodocyclales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_624252_1 984262.SGRA_2777 4.36e-93 277.0 COG1215@1|root,COG1215@2|Bacteria,4NF0S@976|Bacteroidetes,1IRP2@117747|Sphingobacteriia 976|Bacteroidetes M involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_277698_2 1538295.JY96_19445 1.45e-61 197.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,1KM2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Bacterial regulatory proteins, luxR family narL - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_416853_1 1216976.AX27061_3439 4.32e-74 236.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_23,IstB_IS21,rve k59_883539_1 1353529.M899_3086 2.99e-89 279.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2MSRP@213481|Bdellovibrionales,2WJVZ@28221|Deltaproteobacteria 213481|Bdellovibrionales T elongation factor Tu domain 2 protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_316833_1 365044.Pnap_0997 7.63e-120 352.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_388469_1 1249997.JHZW01000002_gene1862 4.57e-19 91.3 COG0845@1|root,COG0845@2|Bacteria,4NG8S@976|Bacteroidetes,1HYRA@117743|Flavobacteriia,2PI1G@252356|Maribacter 976|Bacteroidetes M Protein of unknown function (DUF3347) cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23,HlyD_D4 k59_738482_1 862908.BMS_0574 5.02e-85 261.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2MSV2@213481|Bdellovibrionales,2WIZP@28221|Deltaproteobacteria 213481|Bdellovibrionales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1026719_1 688245.CtCNB1_0151 1.38e-51 173.0 COG0010@1|root,COG0010@2|Bacteria,1MY4S@1224|Proteobacteria,2VK5S@28216|Betaproteobacteria,4AAFB@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the arginase family - - - - - - - - - - - - Arginase k59_702635_1 1454007.JAUG01000061_gene461 1.65e-17 81.3 2ADW0@1|root,313N0@2|Bacteria,4NSUW@976|Bacteroidetes,1ITPF@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_702635_2 216432.CA2559_06545 3.72e-11 65.1 COG0768@1|root,COG0768@2|Bacteria,4NERV@976|Bacteroidetes,1HXSX@117743|Flavobacteriia 976|Bacteroidetes M penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_883571_1 688245.CtCNB1_4329 6.38e-47 157.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHET@28216|Betaproteobacteria,4A9R5@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_883571_2 1276756.AUEX01000012_gene3553 2.03e-30 118.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,4AC0Z@80864|Comamonadaceae 28216|Betaproteobacteria H AMP-binding enzyme paaK_2 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_988035_1 204773.HEAR0836 5.74e-09 56.2 COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,4728Z@75682|Oxalobacteraceae 28216|Betaproteobacteria O transport system cysT - - ko:K02046,ko:K15496 ko00920,ko02010,map00920,map02010 M00185,M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.6.5 - - BPD_transp_1 k59_849113_1 760192.Halhy_6117 5.33e-76 234.0 COG0726@1|root,COG0726@2|Bacteria,4NJK7@976|Bacteroidetes,1IS5R@117747|Sphingobacteriia 976|Bacteroidetes G COGs COG0726 xylanase chitin deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_625818_1 1298593.TOL_2605 7.32e-36 129.0 COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,1SE5X@1236|Gammaproteobacteria,1XRQ4@135619|Oceanospirillales 135619|Oceanospirillales S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_702652_1 1538295.JY96_03225 4.02e-189 532.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,1KJQD@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_702652_2 1268622.AVS7_01235 1.83e-15 75.1 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,4AB8C@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_966141_2 1000565.METUNv1_00006 0.000156 43.1 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_182363_1 83406.HDN1F_11820 3.42e-82 258.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Acyltransferase ws dgat mgat atfA1 - 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_325273_1 614083.AWQR01000004_gene898 2.12e-40 140.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,4AAED@80864|Comamonadaceae 28216|Betaproteobacteria L TIGRFAM hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_466912_1 614083.AWQR01000021_gene235 8.53e-90 270.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria,4ACME@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_503805_1 1000565.METUNv1_01826 2.11e-126 367.0 COG0784@1|root,COG0784@2|Bacteria,1QWFW@1224|Proteobacteria,2VPCN@28216|Betaproteobacteria,2KVZ3@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_503805_2 640081.Dsui_2900 2.49e-169 486.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VKQG@28216|Betaproteobacteria,2KWTH@206389|Rhodocyclales 206389|Rhodocyclales E Conserved region in glutamate synthase - - 2.1.1.21 ko:K22083 ko00680,ko01120,map00680,map01120 - R01586 RC00554 ko00000,ko00001,ko01000 - - - Glu_synthase k59_895437_1 1000565.METUNv1_01545 3.45e-102 312.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2VH0F@28216|Betaproteobacteria,2KVDH@206389|Rhodocyclales 206389|Rhodocyclales G ABC-type sugar transport system, periplasmic component - - - ko:K05813 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - SBP_bac_8 k59_109716_2 640081.Dsui_2139 1.21e-39 140.0 2AM41@1|root,31BY6@2|Bacteria,1RHP5@1224|Proteobacteria,2VSXQ@28216|Betaproteobacteria,2KWPH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3348) - - - - - - - - - - - - DUF3348 k59_288792_1 319003.Bra1253DRAFT_07733 1.47e-45 156.0 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_361363_1 509190.Cseg_2943 1.39e-19 87.8 COG0688@1|root,COG0688@2|Bacteria 2|Bacteria I phosphatidylethanolamine metabolic process psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_361363_2 911045.PSE_3355 1.79e-34 129.0 COG0688@1|root,COG0688@2|Bacteria,1Q633@1224|Proteobacteria,2UMJC@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Phosphatidylserine decarboxylase - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PSDC,PS_Dcarbxylase k59_74974_1 500640.CIT292_06291 8.28e-08 53.1 COG0846@1|root,COG0846@2|Bacteria,1R92Q@1224|Proteobacteria,1S1CG@1236|Gammaproteobacteria 1236|Gammaproteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_896824_1 296591.Bpro_1225 8.44e-40 136.0 COG2963@1|root,COG2963@2|Bacteria,1RI5G@1224|Proteobacteria,2VTTM@28216|Betaproteobacteria,4AFER@80864|Comamonadaceae 28216|Betaproteobacteria L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28 k59_574296_1 760192.Halhy_3412 9.38e-89 274.0 COG1073@1|root,COG1073@2|Bacteria,4NG6A@976|Bacteroidetes,1J0JW@117747|Sphingobacteriia 976|Bacteroidetes S alpha beta - - - - - - - - - - - - - k59_1076752_1 1000565.METUNv1_03883 1.56e-120 365.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KY8Z@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_1076752_2 1000565.METUNv1_03882 1.47e-24 105.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVM2@206389|Rhodocyclales 206389|Rhodocyclales T Periplasmic sensor domain - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_789737_2 1000565.METUNv1_02966 5.62e-27 107.0 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,2KX4B@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_824872_1 1000565.METUNv1_02986 1.72e-163 468.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,2KU6W@206389|Rhodocyclales 206389|Rhodocyclales J ribonuclease, Rne Rng family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_824872_2 1000565.METUNv1_02987 2.91e-44 148.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,2KWAG@206389|Rhodocyclales 206389|Rhodocyclales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_896830_1 1000565.METUNv1_00657 5.99e-115 347.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KUQJ@206389|Rhodocyclales 206389|Rhodocyclales P Transport of potassium into the cell - - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_609478_1 227377.CBU_0905 4.98e-14 65.9 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1JF2H@118969|Legionellales 118969|Legionellales J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_609478_2 1000565.METUNv1_01863 6.86e-54 184.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,2KUEG@206389|Rhodocyclales 206389|Rhodocyclales M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_648445_1 159087.Daro_0225 8.38e-84 268.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,2KUYQ@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg k59_896840_2 1158292.JPOE01000002_gene2331 1.18e-19 88.6 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VJ7D@28216|Betaproteobacteria,1KM6H@119065|unclassified Burkholderiales 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_752986_1 1000565.METUNv1_02588 4.64e-74 235.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,2KVHH@206389|Rhodocyclales 206389|Rhodocyclales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_752986_2 1158146.KB907123_gene770 1.41e-44 157.0 2BWSC@1|root,32R00@2|Bacteria,1RGIQ@1224|Proteobacteria,1S733@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - VPEP k59_1076776_1 1000565.METUNv1_02109 6.02e-37 138.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KUWE@206389|Rhodocyclales 206389|Rhodocyclales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1076776_2 1000565.METUNv1_02108 6.35e-228 627.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,2KUKN@206389|Rhodocyclales 206389|Rhodocyclales J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1076776_3 1000565.METUNv1_02107 9.9e-144 419.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,2KUSA@206389|Rhodocyclales 206389|Rhodocyclales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_824878_1 690597.JH730985_gene923 2.24e-50 174.0 COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,1RZ9Q@1236|Gammaproteobacteria,1YSC5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - - - - - - - - - - Acetyltransf_6,FemAB_like k59_824878_2 1485544.JQKP01000002_gene1386 1.55e-171 493.0 COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2VI0P@28216|Betaproteobacteria,44VP8@713636|Nitrosomonadales 28216|Betaproteobacteria I Beta-ketoacyl synthase, C-terminal domain - GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 ko:K09458,ko:K14660 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_824878_3 1215915.BN193_01675 9.42e-09 54.3 COG0236@1|root,COG0236@2|Bacteria,1VGIY@1239|Firmicutes,4HP0V@91061|Bacilli,1YBUN@1357|Lactococcus 91061|Bacilli IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_789756_1 1000565.METUNv1_00351 1.79e-106 310.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,2KW7U@206389|Rhodocyclales 206389|Rhodocyclales M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K01802,ko:K03767 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_681500_1 358220.C380_22255 8.97e-21 87.4 COG1569@1|root,COG1569@2|Bacteria,1NASM@1224|Proteobacteria,2VVUB@28216|Betaproteobacteria,4AF1G@80864|Comamonadaceae 28216|Betaproteobacteria S PIN domain - - - - - - - - - - - - PIN_3 k59_681500_2 614083.AWQR01000041_gene810 1.25e-84 261.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,4AB1A@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the methyltransferase superfamily rlmL - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_1076783_1 629773.AORY01000004_gene670 2.72e-38 148.0 COG4983@1|root,COG4983@2|Bacteria,1R17Z@1224|Proteobacteria,2TYY5@28211|Alphaproteobacteria,2K6TU@204457|Sphingomonadales 204457|Sphingomonadales T Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - - - - - - - - - - - k59_789760_1 1088721.NSU_0300 1.68e-49 169.0 COG0629@1|root,COG0629@2|Bacteria,1RC22@1224|Proteobacteria 1224|Proteobacteria L ERF superfamily - - - - - - - - - - - - ERF k59_648482_1 1000565.METUNv1_03593 3.59e-57 189.0 COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2VKGI@28216|Betaproteobacteria,2KW58@206389|Rhodocyclales 206389|Rhodocyclales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_1003277_1 1268622.AVS7_02298 1.73e-16 72.8 2E35B@1|root,32Y5A@2|Bacteria,1N850@1224|Proteobacteria,2VURY@28216|Betaproteobacteria,4AICN@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1003277_2 477228.YO5_10789 3.28e-29 105.0 COG3655@1|root,COG3655@2|Bacteria,1NA11@1224|Proteobacteria,1SD6H@1236|Gammaproteobacteria,1Z3GC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Transcriptional regulator - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 k59_505589_1 1000565.METUNv1_03413 1.44e-145 424.0 COG4943@1|root,COG4943@2|Bacteria,1MVTH@1224|Proteobacteria,2VNSA@28216|Betaproteobacteria 28216|Betaproteobacteria T signal transduction protein containing sensor and EAL - - - - - - - - - - - - CSS-motif,EAL k59_184169_1 1095769.CAHF01000019_gene873 4.17e-87 273.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,472N7@75682|Oxalobacteraceae 28216|Betaproteobacteria P TrkA-N domain rosB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_789774_1 1268622.AVS7_04651 1.4e-82 251.0 COG1802@1|root,COG1802@2|Bacteria,1MW9G@1224|Proteobacteria,2VJZQ@28216|Betaproteobacteria,4AD7G@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - FCD,GntR k59_859997_1 614083.AWQR01000039_gene1472 4.41e-90 270.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,4ADI1@80864|Comamonadaceae 28216|Betaproteobacteria S Smr protein MutS2 smrA - - - - - - - - - - - Smr k59_110738_1 1000565.METUNv1_00626 1.97e-121 353.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,2KUKH@206389|Rhodocyclales 206389|Rhodocyclales T Sigma E regulatory protein, MucB RseB rseB - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_648506_1 870187.Thini_1676 2.98e-35 143.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,460U8@72273|Thiotrichales 72273|Thiotrichales Q PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_254342_1 1210884.HG799465_gene12114 8.89e-14 75.9 COG1459@1|root,COG1459@2|Bacteria,2IXYZ@203682|Planctomycetes 203682|Planctomycetes U Type 4 fimbrial assembly protein pilC - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_967083_1 1134474.O59_000907 1.82e-31 117.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,1S2BC@1236|Gammaproteobacteria,1FFZY@10|Cellvibrio 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_967083_2 338966.Ppro_2508 6.12e-43 143.0 2DM6D@1|root,31WQ8@2|Bacteria,1MZ7P@1224|Proteobacteria,430DG@68525|delta/epsilon subdivisions,2WVPJ@28221|Deltaproteobacteria,43VAT@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_40270_1 1000565.METUNv1_02266 1.46e-39 132.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KWRX@206389|Rhodocyclales 206389|Rhodocyclales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_40270_2 85643.Tmz1t_3335 1.01e-113 332.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,2KVE2@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1076833_2 1000565.METUNv1_00278 2.39e-157 451.0 COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,1N4K5@1224|Proteobacteria,2VKGP@28216|Betaproteobacteria,2KVU6@206389|Rhodocyclales 206389|Rhodocyclales T Sigma factor PP2C-like phosphatases - - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_967088_1 1000565.METUNv1_00742 3.66e-48 172.0 COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria,2KV4B@206389|Rhodocyclales 206389|Rhodocyclales U Bacterial type II/III secretion system short domain - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - STN,Secretin,Secretin_N k59_574345_1 1000565.METUNv1_01516 1.3e-98 305.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KV0U@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional activator of acetoin glycerol metabolism - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_648527_1 1000565.METUNv1_03516 4.71e-136 394.0 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VHPT@28216|Betaproteobacteria,2KYD1@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_397400_1 1000565.METUNv1_00721 0.0 1026.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,2KUJV@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1039654_1 1282362.AEAC466_05400 1.31e-22 95.9 COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria 1224|Proteobacteria P Citrate transporter ybiR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - CitMHS k59_290283_1 365044.Pnap_3566 1.28e-91 285.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,4ABM7@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase phbC2 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_254372_2 944547.ABLL_1867 6.26e-15 80.5 COG5362@1|root,COG5362@2|Bacteria,1N1KT@1224|Proteobacteria,42N35@68525|delta/epsilon subdivisions,2YN75@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TIGRFAM Phage - - - - - - - - - - - - - k59_505671_1 358220.C380_09615 1.79e-74 246.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AGAQ@80864|Comamonadaceae 28216|Betaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein - - - ko:K03406,ko:K03776,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_753038_1 153496.JNAB01000024_gene2750 4.83e-10 60.5 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,2JR61@204441|Rhodospirillales 204441|Rhodospirillales L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_824975_1 1000565.METUNv1_00376 4.56e-107 336.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales 206389|Rhodocyclales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1076894_2 1000565.METUNv1_02048 2.58e-63 203.0 2DXAK@1|root,3444R@2|Bacteria,1P2FA@1224|Proteobacteria,2W41N@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1076894_3 1000565.METUNv1_02049 1.13e-30 120.0 COG0598@1|root,COG0598@2|Bacteria,1R7FC@1224|Proteobacteria,2VKBA@28216|Betaproteobacteria,2KUWR@206389|Rhodocyclales 206389|Rhodocyclales P Magnesium transport protein CorA - - - - - - - - - - - - CorA k59_1003349_2 1000565.METUNv1_04045 5.26e-180 561.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_1109952_1 870187.Thini_4450 4.11e-11 69.3 COG3220@1|root,COG3220@2|Bacteria,1R9AA@1224|Proteobacteria,1S3KZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1003353_1 1000565.METUNv1_01897 1.91e-143 421.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,2KUTU@206389|Rhodocyclales 206389|Rhodocyclales L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_648595_1 1120977.JHUX01000003_gene2052 2.12e-12 63.2 COG3759@1|root,COG3759@2|Bacteria,1MZ4F@1224|Proteobacteria,1S90R@1236|Gammaproteobacteria,3NNHC@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1304) - - - ko:K08987 - - - - ko00000 - - - DUF1304 k59_648595_2 1150621.SMUL_2133 5.08e-34 123.0 COG1280@1|root,COG1280@2|Bacteria,1RA1G@1224|Proteobacteria,42ZTY@68525|delta/epsilon subdivisions 1224|Proteobacteria E LysE type translocator - - - - - - - - - - - - LysE k59_505690_2 1485544.JQKP01000007_gene1989 3.73e-305 852.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,44VEM@713636|Nitrosomonadales 28216|Betaproteobacteria O TIGRFAM cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_860055_2 640081.Dsui_0008 1.9e-19 81.3 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,2KWPQ@206389|Rhodocyclales 206389|Rhodocyclales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_789855_1 929713.NIASO_19825 2.9e-37 136.0 COG2382@1|root,COG2382@2|Bacteria,4NI86@976|Bacteroidetes,1IQ5J@117747|Sphingobacteriia 976|Bacteroidetes P Putative esterase - - - - - - - - - - - - Esterase k59_40344_1 1000565.METUNv1_02302 7.24e-72 231.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,2KUDC@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_648619_1 1089544.KB912942_gene110 2.6e-22 101.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4DXHP@85010|Pseudonocardiales 201174|Actinobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_397469_2 946077.W5A_05188 5.32e-12 63.9 COG0353@1|root,COG0353@2|Bacteria,4NEWI@976|Bacteroidetes,1HY9T@117743|Flavobacteriia 976|Bacteroidetes L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1039704_1 1403819.BATR01000096_gene3146 1.89e-55 187.0 COG0743@1|root,COG0743@2|Bacteria,46S90@74201|Verrucomicrobia,2ITI1@203494|Verrucomicrobiae 203494|Verrucomicrobiae I 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_184313_2 948106.AWZT01000035_gene2427 5.69e-21 94.7 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,1K3UZ@119060|Burkholderiaceae 28216|Betaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1121651_2 570952.ATVH01000011_gene353 5.58e-41 155.0 2EXSU@1|root,33R23@2|Bacteria,1NS77@1224|Proteobacteria,2UR4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_730624_2 1000565.METUNv1_02819 5.65e-33 115.0 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,2KWZ9@206389|Rhodocyclales 206389|Rhodocyclales J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_88297_1 83406.HDN1F_20760 5.64e-89 275.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1J4X8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0229 family yeaH - - ko:K09786 - - - - ko00000 - - - DUF444 k59_804114_1 743722.Sph21_0641 1.49e-24 100.0 COG1595@1|root,COG1595@2|Bacteria,4NMIC@976|Bacteroidetes,1IS0G@117747|Sphingobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_909591_1 338969.Rfer_2041 8.57e-74 241.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,4AA85@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ABC transporter related - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_456321_1 1198452.Jab_2c04030 1.09e-83 273.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4728J@75682|Oxalobacteraceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_979373_1 595537.Varpa_1936 1.18e-75 248.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,4AAGE@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_873938_1 614083.AWQR01000048_gene3231 2.76e-43 152.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,4AACM@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_873938_2 338969.Rfer_2106 3.06e-36 136.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,4AA2Y@80864|Comamonadaceae 28216|Betaproteobacteria L TIGRFAM ATP-dependent helicase HrpA hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_205569_1 1215092.PA6_024_00180 7.94e-119 358.0 COG1524@1|root,COG1524@2|Bacteria,1PGPZ@1224|Proteobacteria,1RYR2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PglZ domain - - - - - - - - - - - - PglZ k59_730635_1 1198452.Jab_1c18670 4.65e-91 268.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,4739J@75682|Oxalobacteraceae 28216|Betaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 ko:K03601,ko:K04564 ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000,ko03400 - - - Sod_Fe_C,Sod_Fe_N k59_730635_2 1198452.Jab_1c18690 6.05e-12 65.5 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,473KB@75682|Oxalobacteraceae 28216|Betaproteobacteria F Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase,HTH_6,SIS k59_527584_1 338969.Rfer_1300 6.42e-47 162.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,4A9Z3@80864|Comamonadaceae 28216|Betaproteobacteria I phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_527584_2 1123255.JHYS01000019_gene1733 9.6e-23 94.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,4ACBH@80864|Comamonadaceae 28216|Betaproteobacteria L Endonuclease exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_124094_2 340177.Cag_0565 4.72e-19 83.6 COG0503@1|root,COG0503@2|Bacteria,1FE1Q@1090|Chlorobi 1090|Chlorobi F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_670884_1 640081.Dsui_3208 1.73e-99 296.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,2KVD7@206389|Rhodocyclales 206389|Rhodocyclales E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_585161_1 1121011.AUCB01000028_gene3058 2.07e-12 67.4 COG1804@1|root,COG1804@2|Bacteria,4NEA8@976|Bacteroidetes,1I0MK@117743|Flavobacteriia,23I37@178469|Arenibacter 976|Bacteroidetes C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_585161_2 1122132.AQYH01000007_gene2016 4.88e-18 84.7 COG0673@1|root,COG0673@2|Bacteria,1PCQM@1224|Proteobacteria,2U32X@28211|Alphaproteobacteria,4BBD8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_693998_2 1000565.METUNv1_02436 2.42e-94 280.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,2KV5N@206389|Rhodocyclales 206389|Rhodocyclales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_527617_1 522306.CAP2UW1_3441 2.32e-37 140.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,1KQEF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_527617_2 748247.AZKH_3709 2.42e-14 72.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KVUY@206389|Rhodocyclales 206389|Rhodocyclales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_979398_1 929556.Solca_3438 6.09e-07 55.8 COG2913@1|root,COG2913@2|Bacteria,4NP4N@976|Bacteroidetes,1IUMP@117747|Sphingobacteriia 976|Bacteroidetes J Domain of unknown function (DUF4476) - - - - - - - - - - - - DUF4476,SmpA_OmlA k59_482340_1 1281779.H009_20986 3.28e-34 128.0 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,2TV0H@28211|Alphaproteobacteria,4BMDT@82115|Rhizobiaceae 28211|Alphaproteobacteria K LysR substrate binding domain MA20_04270 - - - - - - - - - - - HTH_1,LysR_substrate k59_348776_1 1000565.METUNv1_02486 1.11e-105 321.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,2VSM7@28216|Betaproteobacteria,2KWS4@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_456382_1 1000565.METUNv1_03432 9.55e-102 302.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,2M01D@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF692) - - - - - - - - - - - - DUF692 k59_53519_1 395495.Lcho_4332 7.83e-88 271.0 COG2223@1|root,COG2223@2|Bacteria,1QUFF@1224|Proteobacteria,2WHQI@28216|Betaproteobacteria 28216|Betaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_527654_1 279714.FuraDRAFT_1725 2.81e-82 258.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,2VJP3@28216|Betaproteobacteria,2KR36@206351|Neisseriales 206351|Neisseriales S Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_527654_2 1225785.CM001983_gene3542 2.9e-09 58.2 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,1RNBP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage protein gp29 - - - - - - - - - - - - DUF935 k59_1055333_1 1122236.KB905142_gene434 1.11e-70 213.0 COG2337@1|root,COG2337@2|Bacteria,1RH4Z@1224|Proteobacteria,2VVSM@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM PemK family protein chpB - - ko:K18841 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin k59_1055333_2 1158292.JPOE01000002_gene2715 1.3e-40 135.0 COG2336@1|root,COG2336@2|Bacteria,1N3AU@1224|Proteobacteria,2VYDH@28216|Betaproteobacteria 28216|Betaproteobacteria T SpoVT / AbrB like domain - - - ko:K18842 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_17163_1 1268622.AVS7_01855 1.83e-69 228.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,4AA5M@80864|Comamonadaceae 28216|Betaproteobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_53527_1 1095769.CAHF01000014_gene3047 1.27e-92 284.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,4739Y@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_456411_1 1112217.PPL19_07386 3.58e-46 159.0 COG0560@1|root,COG0560@2|Bacteria,1R4DN@1224|Proteobacteria,1SK4Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Phosphorylcholine phosphatase pchP - - ko:K21830 - - - - ko00000 - - - - k59_552355_1 795666.MW7_2822 3.72e-33 122.0 COG1192@1|root,COG1192@2|Bacteria,1RACE@1224|Proteobacteria,2VSW2@28216|Betaproteobacteria,1K089@119060|Burkholderiaceae 28216|Betaproteobacteria D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1121708_1 366602.Caul_0618 5.63e-22 95.9 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2KI4N@204458|Caulobacterales 204458|Caulobacterales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1121708_2 1095769.CAHF01000026_gene1646 2.95e-22 97.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,472VU@75682|Oxalobacteraceae 28216|Betaproteobacteria NT methyl-accepting chemotaxis protein - - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH k59_17178_1 1000565.METUNv1_02002 2.04e-31 126.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KXVJ@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_942411_1 1217712.F971_00926 2.56e-116 352.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,3NIYP@468|Moraxellaceae 1236|Gammaproteobacteria I Biotin carboxylase C-terminal domain mccA - 6.4.1.4,6.4.1.5 ko:K01968,ko:K13777 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R03494,R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_804189_1 1123248.KB893314_gene3313 2.39e-47 155.0 COG0094@1|root,COG0094@2|Bacteria,4NEGY@976|Bacteroidetes,1IPX4@117747|Sphingobacteriia 976|Bacteroidetes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_804189_2 1267211.KI669560_gene1330 3.83e-50 159.0 COG0199@1|root,COG0199@2|Bacteria,4NQ6N@976|Bacteroidetes,1ISRK@117747|Sphingobacteriia 976|Bacteroidetes J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_1055376_1 945543.VIBR0546_02539 2.28e-15 70.1 2EJHZ@1|root,33D8X@2|Bacteria,1QMUP@1224|Proteobacteria,1TK53@1236|Gammaproteobacteria,1Y233@135623|Vibrionales 135623|Vibrionales S Helix-turn-helix domain - - - - - - - - - - - - HTH_17 k59_838892_1 1449049.JONW01000011_gene2385 5.56e-07 52.8 COG1262@1|root,COG4301@1|root,COG1262@2|Bacteria,COG4301@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,2KFXT@204458|Caulobacterales 204458|Caulobacterales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_33 k59_838892_2 349521.HCH_06304 1.55e-24 103.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1XHHC@135619|Oceanospirillales 135619|Oceanospirillales S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1055382_1 251221.35213476 4.08e-09 60.1 COG0712@1|root,COG0712@2|Bacteria,1G5SS@1117|Cyanobacteria 1117|Cyanobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1055382_2 1120977.JHUX01000007_gene188 1.36e-05 46.6 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,3NJ2E@468|Moraxellaceae 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1017006_1 1198452.Jab_2c33710 1.07e-115 346.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,473Q4@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_979478_2 395494.Galf_1127 4.98e-51 163.0 COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,2VSZE@28216|Betaproteobacteria,44WGK@713636|Nitrosomonadales 28216|Betaproteobacteria L HNH nucleases - - - - - - - - - - - - HNH k59_909687_1 883126.HMPREF9710_00686 0.000789 41.2 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2VIEF@28216|Betaproteobacteria,4727I@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the peptidase S33 family pip GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_909687_2 714943.Mucpa_0744 1.34e-13 73.6 COG5285@1|root,COG5285@2|Bacteria,4NG3B@976|Bacteroidetes,1IQVV@117747|Sphingobacteriia 976|Bacteroidetes Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_1121734_1 159087.Daro_3905 4.24e-59 196.0 COG0598@1|root,COG2239@1|root,COG0598@2|Bacteria,COG2239@2|Bacteria,1MWMP@1224|Proteobacteria,2VHH3@28216|Betaproteobacteria,2M014@206389|Rhodocyclales 206389|Rhodocyclales P CorA-like Mg2+ transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1121734_2 105559.Nwat_2515 3.57e-39 132.0 COG2026@1|root,COG2026@2|Bacteria,1N2YY@1224|Proteobacteria,1SA10@1236|Gammaproteobacteria,1X1F4@135613|Chromatiales 135613|Chromatiales DJ Addiction module toxin, RelE StbE family - - - ko:K07334 - - - - ko00000,ko02048 - - - - k59_1121734_3 493475.GARC_2280 1.04e-39 133.0 COG1476@1|root,COG1476@2|Bacteria,1QWRE@1224|Proteobacteria,1T2XD@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_1121734_4 748247.AZKH_3009 1.76e-07 50.8 2CZS8@1|root,32T71@2|Bacteria,1N4G2@1224|Proteobacteria,2VUSW@28216|Betaproteobacteria,2KWYM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_482434_1 7213.XP_004533140.1 7.61e-54 190.0 COG0445@1|root,KOG2311@2759|Eukaryota,38BWB@33154|Opisthokonta,3BFG6@33208|Metazoa,3CTUH@33213|Bilateria,41TFM@6656|Arthropoda,3SKGZ@50557|Insecta,4520R@7147|Diptera 33208|Metazoa J Flavin adenine dinucleotide binding. It is involved in the biological process described with tRNA wobble uridine modification - - - - - - - - - - - - GIDA,GIDA_assoc,GidB k59_124198_1 640081.Dsui_2238 1.07e-78 250.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,2KWWE@206389|Rhodocyclales 206389|Rhodocyclales E ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_874065_1 762376.AXYL_03767 5.7e-147 428.0 COG1848@1|root,COG1848@2|Bacteria,1QZY6@1224|Proteobacteria,2VYXC@28216|Betaproteobacteria 28216|Betaproteobacteria S Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_874065_2 1297742.A176_05830 1.77e-166 472.0 COG1637@1|root,COG1637@2|Bacteria,1PKGJ@1224|Proteobacteria,42WV3@68525|delta/epsilon subdivisions,2WT85@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - - - - - - - - - - NucS k59_942455_1 1000565.METUNv1_01192 9.87e-35 123.0 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,2VX03@28216|Betaproteobacteria,2KX5V@206389|Rhodocyclales 206389|Rhodocyclales NU Prokaryotic N-terminal methylation motif - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_1055438_1 1349767.GJA_1377 9.11e-15 70.9 COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,2WFRP@28216|Betaproteobacteria,477NA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Poly(hydroxyalcanoate) granule associated protein (phasin) - - - - - - - - - - - - Phasin k59_1055438_2 338969.Rfer_3526 2.87e-42 154.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria,4AB29@80864|Comamonadaceae 28216|Betaproteobacteria M Male sterility protein - - - - - - - - - - - - NAD_binding_4,adh_short k59_348925_1 555793.WSK_0964 3.82e-98 303.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,2K026@204457|Sphingomonadales 204457|Sphingomonadales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_552440_1 1419583.V466_00205 1.75e-109 323.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_1092424_1 1504672.669785233 7.72e-06 50.8 COG3307@1|root,COG3307@2|Bacteria,1MYWJ@1224|Proteobacteria,2VKHZ@28216|Betaproteobacteria,4AAEY@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM O-antigen polymerase - - - - - - - - - - - - PglL_A,Wzy_C,Wzy_C_2 k59_909713_2 1000565.METUNv1_03477 1.2e-77 233.0 2DM6D@1|root,31WQ8@2|Bacteria,1MZ7P@1224|Proteobacteria,2VUHB@28216|Betaproteobacteria,2KYYM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_585261_1 1000565.METUNv1_01401 3.57e-44 147.0 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,2KWV6@206389|Rhodocyclales 206389|Rhodocyclales U Biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_585261_2 511062.GU3_09255 1.67e-16 78.6 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1Y3DJ@135624|Aeromonadales 135624|Aeromonadales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_456540_1 59538.XP_005963379.1 7.39e-15 73.9 COG1845@1|root,KOG4297@1|root,KOG4297@2759|Eukaryota,KOG4664@2759|Eukaryota,3A251@33154|Opisthokonta,3BQPX@33208|Metazoa,3D7U9@33213|Bilateria,48EB5@7711|Chordata,49AYU@7742|Vertebrata,3JGPH@40674|Mammalia,4J583@91561|Cetartiodactyla 33208|Metazoa TV C-type lectin domain family 2 member CLEC2D GO:0001765,GO:0001817,GO:0001910,GO:0001911,GO:0002253,GO:0002376,GO:0002429,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002696,GO:0002697,GO:0002698,GO:0002703,GO:0002704,GO:0002706,GO:0002707,GO:0002715,GO:0002716,GO:0002757,GO:0002761,GO:0002762,GO:0002764,GO:0002768,GO:0003674,GO:0004888,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006952,GO:0006968,GO:0007154,GO:0007165,GO:0007166,GO:0008064,GO:0008104,GO:0008150,GO:0009889,GO:0009897,GO:0009986,GO:0009987,GO:0010556,GO:0016020,GO:0016021,GO:0016043,GO:0019222,GO:0022607,GO:0023052,GO:0030246,GO:0030832,GO:0030833,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0031341,GO:0031342,GO:0031347,GO:0031348,GO:0031579,GO:0032271,GO:0032535,GO:0032663,GO:0032944,GO:0032956,GO:0032970,GO:0033036,GO:0033043,GO:0034613,GO:0038023,GO:0042035,GO:0042127,GO:0042129,GO:0042269,GO:0042270,GO:0043113,GO:0043254,GO:0044085,GO:0044087,GO:0044091,GO:0044421,GO:0044425,GO:0044459,GO:0044464,GO:0045076,GO:0045088,GO:0045595,GO:0045596,GO:0045637,GO:0045638,GO:0045670,GO:0045671,GO:0045824,GO:0045953,GO:0046703,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050670,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050851,GO:0050852,GO:0050863,GO:0050865,GO:0050867,GO:0050896,GO:0051093,GO:0051128,GO:0051171,GO:0051179,GO:0051239,GO:0051241,GO:0051246,GO:0051249,GO:0051251,GO:0051493,GO:0051641,GO:0051668,GO:0051716,GO:0060089,GO:0060255,GO:0061024,GO:0065007,GO:0065008,GO:0070663,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0080090,GO:0080134,GO:0090066,GO:0098552,GO:0110053,GO:1902105,GO:1902106,GO:1902903,GO:1903706,GO:1903707,GO:2000026,GO:2000520,GO:2000522 - ko:K06468,ko:K10071,ko:K10072 ko04640,ko05167,ko05169,map04640,map05167,map05169 - - - ko00000,ko00001,ko04090,ko04091 - - - Lectin_C k59_456540_2 9978.XP_004600107.1 1.42e-11 65.1 KOG1420@1|root,KOG1420@2759|Eukaryota,38CH0@33154|Opisthokonta,3BBT1@33208|Metazoa,3E4BF@33213|Bilateria,486FR@7711|Chordata,496VH@7742|Vertebrata,3J5XK@40674|Mammalia,35MJC@314146|Euarchontoglires 33208|Metazoa P Potassium channel, subfamily U, member KCNU1 GO:0000003,GO:0003674,GO:0005215,GO:0005216,GO:0005227,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0007338,GO:0008037,GO:0008076,GO:0008150,GO:0008324,GO:0009566,GO:0009987,GO:0009988,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015269,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0019953,GO:0022414,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0031647,GO:0032991,GO:0034220,GO:0034702,GO:0034703,GO:0034705,GO:0035036,GO:0044425,GO:0044459,GO:0044464,GO:0044703,GO:0046873,GO:0050821,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0060072,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:1902495,GO:1990351 - ko:K05274 ko04022,ko04270,ko04911,map04022,map04270,map04911 - - - ko00000,ko00001,ko04040 1.A.1.3.5 - - BK_channel_a,Ion_trans,Ion_trans_2 k59_268679_2 596153.Alide_0725 2.55e-05 45.1 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,4AASI@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_21,rve,rve_3 k59_909718_2 887062.HGR_14939 5.25e-10 59.7 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2VI7R@28216|Betaproteobacteria,4AA3X@80864|Comamonadaceae 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_125678_1 1100721.ALKO01000021_gene568 2.56e-18 81.3 COG1846@1|root,COG1846@2|Bacteria,1N7PQ@1224|Proteobacteria,2VTDX@28216|Betaproteobacteria,4ADXM@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein, MarR - - - - - - - - - - - - MarR,MarR_2 k59_125678_2 477228.YO5_13283 2.58e-38 132.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1Z1YI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Alkyl hydroperoxide reductase subunit C ahpC GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_377861_1 1121035.AUCH01000004_gene326 3e-45 169.0 COG1538@1|root,COG1538@2|Bacteria,1NEHN@1224|Proteobacteria,2VYWE@28216|Betaproteobacteria 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_229083_1 1000565.METUNv1_00988 1.18e-64 204.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VJXH@28216|Betaproteobacteria,2KWEN@206389|Rhodocyclales 206389|Rhodocyclales P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - - - - - - - - - - ABC_tran k59_229083_2 1000565.METUNv1_00989 1.1e-13 70.1 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,2KUGI@206389|Rhodocyclales 206389|Rhodocyclales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - - - - - - - - - - NMT1_2 k59_875719_1 1163617.SCD_n00573 5.48e-67 223.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type II and III secretion system protein exeD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N_2 k59_207999_1 1144319.PMI16_01523 4.12e-76 234.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,47444@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_554200_1 640081.Dsui_0258 1.14e-62 203.0 COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2VH92@28216|Betaproteobacteria,2KUZ0@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system cysA - 3.6.3.25 ko:K02045 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.1,3.A.1.6.3 - - ABC_tran,TOBE_3 k59_1057748_1 358220.C380_18035 1.68e-47 162.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,4AAK2@80864|Comamonadaceae 28216|Betaproteobacteria P Rieske 2Fe-2S alcE - 1.14.15.7 ko:K00499 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_270314_1 232721.Ajs_3496 6.76e-78 251.0 COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VHXV@28216|Betaproteobacteria,4ABXZ@80864|Comamonadaceae 28216|Betaproteobacteria EH TIGRFAM para-aminobenzoate synthase, subunit I pabB - 2.6.1.85,4.1.3.38 ko:K01665,ko:K03342 ko00790,map00790 - R01716,R05553 RC00010,RC01418,RC01843,RC02148 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4,Chorismate_bind k59_709839_1 358220.C380_16180 9.44e-87 261.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,4ABJC@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_33047_1 883126.HMPREF9710_00606 2.1e-127 369.0 COG1175@1|root,COG1175@2|Bacteria,1MU84@1224|Proteobacteria,2VN7H@28216|Betaproteobacteria,473SP@75682|Oxalobacteraceae 28216|Betaproteobacteria G Binding-protein-dependent transport system inner membrane component - - - ko:K17316 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 k59_709852_1 272568.GDI3673 3.17e-89 274.0 2DVPY@1|root,33WQ8@2|Bacteria,1N9VQ@1224|Proteobacteria,2UIC5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_995155_1 1000565.METUNv1_02611 1.42e-152 458.0 COG0840@1|root,COG3829@1|root,COG0840@2|Bacteria,COG3829@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KU84@206389|Rhodocyclales 206389|Rhodocyclales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS,PAS_9,TarH k59_177686_2 1137799.GZ78_09760 5.37e-06 50.1 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1RWVW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Lactamase_B,Lactamase_B_2 k59_177687_1 936053.I1BLE9 5.08e-18 96.7 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi,1GXN4@112252|Fungi incertae sedis 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_106331_2 697282.Mettu_0664 1.53e-18 90.5 COG0642@1|root,COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_69421_1 640081.Dsui_2723 1.48e-94 290.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,2KVE3@206389|Rhodocyclales 206389|Rhodocyclales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_140407_1 452638.Pnec_0337 1.61e-103 318.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,1JZU0@119060|Burkholderiaceae 28216|Betaproteobacteria H acetolactate synthase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_995203_1 204669.Acid345_3092 1.04e-09 64.7 2AM5X@1|root,31C0B@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_570322_1 1380394.JADL01000009_gene3112 8.87e-08 57.8 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,2JSP4@204441|Rhodospirillales 204441|Rhodospirillales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_69464_1 204669.Acid345_3021 3.33e-42 157.0 COG4447@1|root,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria 57723|Acidobacteria M Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_570336_1 1000565.METUNv1_02611 1.35e-67 229.0 COG0840@1|root,COG3829@1|root,COG0840@2|Bacteria,COG3829@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KU84@206389|Rhodocyclales 206389|Rhodocyclales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS,PAS_9,TarH k59_177756_1 946483.Cenrod_2386 2.43e-17 87.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AB4J@80864|Comamonadaceae 28216|Betaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,HAMP,MCPsignal,TarH k59_1103468_2 392500.Swoo_2978 1.07e-21 93.6 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2QB1W@267890|Shewanellaceae 1236|Gammaproteobacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_140466_1 1094466.KQS_10260 2.02e-87 267.0 2EX7I@1|root,33QID@2|Bacteria,4P0MY@976|Bacteroidetes,1I7AW@117743|Flavobacteriia,2NUGF@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_747811_1 1177179.A11A3_11342 3.2e-18 88.2 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1XJH2@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_995268_1 1095769.CAHF01000014_gene3027 3.12e-90 276.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,4734G@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_140485_1 393595.ABO_0822 2.84e-20 89.7 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1RENP@1224|Proteobacteria,1S4IW@1236|Gammaproteobacteria,1XJ8G@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the ompA family oprF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_140485_2 1229205.BUPH_01589 9.88e-18 83.2 2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,1K3DF@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 k59_177800_1 1000565.METUNv1_02727 5.06e-105 315.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,2KUWK@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate cmk - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin,EPSP_synthase k59_1138290_1 1500894.JQNN01000001_gene3323 4.66e-34 120.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,4749Z@75682|Oxalobacteraceae 28216|Betaproteobacteria I Thioesterase superfamily yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_1138290_2 1123399.AQVE01000001_gene630 9.42e-12 67.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,46223@72273|Thiotrichales 72273|Thiotrichales V involved in Fe-S cluster assembly - - - - - - - - - - - - ABC_membrane,ABC_tran k59_570386_2 382245.ASA_1981 2.93e-21 89.0 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,1SC87@1236|Gammaproteobacteria,1Y5XW@135624|Aeromonadales 135624|Aeromonadales S FixH - - - ko:K09926 - - - - ko00000 - - - FixH k59_956549_1 1000565.METUNv1_02575 1.68e-263 747.0 COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,2VN60@28216|Betaproteobacteria,2KYVB@206389|Rhodocyclales 206389|Rhodocyclales L DEAD-like helicases superfamily - - - - - - - - - - - - - k59_710006_1 106648.BBLJ01000017_gene3539 1.39e-120 360.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,3NJ38@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_33192_1 869213.JCM21142_41524 3.28e-15 79.0 COG1305@1|root,COG1305@2|Bacteria,4NI6P@976|Bacteroidetes,47KR7@768503|Cytophagia 976|Bacteroidetes E Transglutaminase-like superfamily - - - - - - - - - - - - DUF3857,Transglut_core k59_285161_1 864051.BurJ1DRAFT_1662 1.71e-18 84.3 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,1KJSS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Domain of unknown function (DUF1732) yicC - - - - - - - - - - - DUF1732,YicC_N k59_285161_2 864051.BurJ1DRAFT_1663 1.94e-34 125.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,1KJQ3@119065|unclassified Burkholderiales 28216|Betaproteobacteria KLT Serine threonine protein kinase spkD - - - - - - - - - - - Pkinase k59_424180_1 640081.Dsui_0830 9.03e-25 101.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,2KV12@206389|Rhodocyclales 206389|Rhodocyclales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_424180_2 640081.Dsui_0831 1.58e-65 212.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KUSQ@206389|Rhodocyclales 206389|Rhodocyclales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_247332_1 929556.Solca_3790 1.6e-56 201.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IRKC@117747|Sphingobacteriia 976|Bacteroidetes M Tricorn protease homolog - - - - - - - - - - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_428182_1 1121098.HMPREF1534_00204 4.13e-23 101.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia,4AK8A@815|Bacteroidaceae 976|Bacteroidetes G glycosyl hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_784139_1 1230338.MOMA_05821 1.01e-08 62.0 COG0484@1|root,COG5263@1|root,COG0484@2|Bacteria,COG5263@2|Bacteria,1PW1V@1224|Proteobacteria,1TEGQ@1236|Gammaproteobacteria,3NQ79@468|Moraxellaceae 1236|Gammaproteobacteria O heat shock protein binding - - - - - - - - - - - - DUF805 k59_784144_1 930169.B5T_02315 5.02e-92 280.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,1XIED@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_961545_1 1000565.METUNv1_01097 1.85e-11 63.2 COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2VMBA@28216|Betaproteobacteria,2KZRY@206389|Rhodocyclales 206389|Rhodocyclales P Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K15553 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.2 - - NMT1 k59_961545_2 1000565.METUNv1_01096 7e-71 225.0 COG1960@1|root,COG1960@2|Bacteria,1MYT7@1224|Proteobacteria,2VIFP@28216|Betaproteobacteria,2KXXG@206389|Rhodocyclales 206389|Rhodocyclales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_247413_1 1000565.METUNv1_01868 4.55e-34 129.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,2KUNY@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_784207_1 1207076.ALAT01000160_gene3260 1.76e-118 370.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1Z1AB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_784212_1 640081.Dsui_0363 4.25e-90 266.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,2KVWF@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_961601_1 1144319.PMI16_02501 1.58e-43 157.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,47368@75682|Oxalobacteraceae 28216|Betaproteobacteria I PFAM Acyl-CoA dehydrogenase N terminal, Acyl-CoA dehydrogenase, C-terminal domain, Acyl-CoA dehydrogenase, middle domain, Acyl-CoA dehydrogenase, N-terminal domain - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_961601_2 1095769.CAHF01000006_gene1967 3.55e-25 97.8 COG2314@1|root,COG2314@2|Bacteria,1PSQY@1224|Proteobacteria,2WAAH@28216|Betaproteobacteria,474V9@75682|Oxalobacteraceae 28216|Betaproteobacteria S TM2 domain - - - - - - - - - - - - TM2 k59_428261_1 1000565.METUNv1_03578 2.47e-116 356.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VNJM@28216|Betaproteobacteria,2KZRM@206389|Rhodocyclales 206389|Rhodocyclales IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_635756_1 1121035.AUCH01000004_gene403 2.28e-118 361.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,2KV3Z@206389|Rhodocyclales 206389|Rhodocyclales C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_784232_1 1000565.METUNv1_01432 1.4e-207 597.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,2KVX3@206389|Rhodocyclales 206389|Rhodocyclales P receptor - - - ko:K16090 - - - - ko00000,ko02000 1.B.14.1.11 - - Plug,TonB_dep_Rec k59_428285_1 640081.Dsui_0943 7.03e-99 301.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,2KV00@206389|Rhodocyclales 206389|Rhodocyclales C Dinitrogenase iron-molybdenum cofactor - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_604663_1 94624.Bpet4766 2.48e-144 417.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,3T2W1@506|Alcaligenaceae 28216|Betaproteobacteria G C4-dicarboxylate ABC transporter - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_961685_1 398578.Daci_1959 2.3e-46 168.0 COG4678@1|root,COG4678@2|Bacteria 2|Bacteria - - traG - - ko:K12056 - - - - ko00000,ko02044 3.A.7.11.1 - - TraG_N k59_604699_1 408672.NBCG_01738 5.08e-79 246.0 COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4DU7B@85009|Propionibacteriales 201174|Actinobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_247547_1 1157708.KB907450_gene5653 1.4e-96 288.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2VNZ2@28216|Betaproteobacteria,4AJSM@80864|Comamonadaceae 28216|Betaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_961743_1 670307.HYPDE_35033 1.53e-78 242.0 2BS4I@1|root,32M5F@2|Bacteria,1PB9H@1224|Proteobacteria,2UYPP@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_604840_1 640081.Dsui_0636 1.32e-100 297.0 COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2VJ8A@28216|Betaproteobacteria,2KVZV@206389|Rhodocyclales 206389|Rhodocyclales P Binding-protein-dependent transport system inner membrane component - - - ko:K10003 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_604840_2 640081.Dsui_0637 3.24e-10 58.9 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIQB@28216|Betaproteobacteria,2KW71@206389|Rhodocyclales 206389|Rhodocyclales P Binding-protein-dependent transport system inner membrane component - - - ko:K10002 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_961870_1 751945.Theos_0479 1.14e-64 218.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1WIX1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus GM COGs COG2148 Sugar transferase involved in lipopolysaccharide synthesis - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_247670_1 243233.MCA2188 3.15e-26 105.0 2EFC8@1|root,33955@2|Bacteria,1NCIW@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_247670_2 243233.MCA2187 3.42e-15 75.9 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,1XE21@135618|Methylococcales 135618|Methylococcales P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_784511_1 640081.Dsui_0370 5.91e-37 127.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,2KW37@206389|Rhodocyclales 206389|Rhodocyclales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_784511_2 640081.Dsui_0369 4.55e-59 188.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,2KUA3@206389|Rhodocyclales 206389|Rhodocyclales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_962071_1 555778.Hneap_0824 1.97e-95 299.0 28HN3@1|root,2Z7WH@2|Bacteria,1MWH8@1224|Proteobacteria,1RYMP@1236|Gammaproteobacteria,1WXH2@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - ko:K19117 - - - - ko00000,ko02048 - - - Cas_Csd1 k59_605092_1 1121033.AUCF01000044_gene4592 8.57e-71 222.0 COG1028@1|root,COG1028@2|Bacteria,1RB0T@1224|Proteobacteria,2UA6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_247981_1 864051.BurJ1DRAFT_2704 1.69e-50 168.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VN0D@28216|Betaproteobacteria,1KKFJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_247981_2 62928.azo2524 2.82e-100 300.0 COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2VID0@28216|Betaproteobacteria,2KY10@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_605247_1 1198452.Jab_2c10830 2.08e-23 97.4 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,473WM@75682|Oxalobacteraceae 28216|Betaproteobacteria P Major Facilitator Superfamily narK - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_605247_2 204773.HEAR1651 1.46e-61 203.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,472ND@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_962331_1 1316927.ATKI01000065_gene2021 1.06e-25 112.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1YMNV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria NT methyl-accepting chemotaxis protein VPA0491 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,HBM,MCPsignal k59_605380_1 1000565.METUNv1_02234 7.62e-95 297.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria,2KW15@206389|Rhodocyclales 206389|Rhodocyclales M Sulfatase - - - - - - - - - - - - Sulfatase k59_962376_1 742766.HMPREF9455_03775 5.65e-07 52.0 COG1216@1|root,COG1216@2|Bacteria,4NQSJ@976|Bacteroidetes,2G0B2@200643|Bacteroidia,2324T@171551|Porphyromonadaceae 976|Bacteroidetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_962376_2 583345.Mmol_0910 5.3e-35 135.0 COG0438@1|root,COG0457@1|root,COG3914@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,2KMDJ@206350|Nitrosomonadales 206350|Nitrosomonadales O Glycosyltransferase like family - - - - - - - - - - - - Glyco_tranf_2_5,Glyco_transf_41,Methyltransf_12,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_784937_2 864051.BurJ1DRAFT_1028 2.01e-26 105.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2VHMG@28216|Betaproteobacteria,1KK8E@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nitrogenase molybdenum-iron protein, alpha nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_962426_1 1522072.IL54_2259 1.92e-05 47.4 COG1024@1|root,COG1024@2|Bacteria,1QGFN@1224|Proteobacteria,2U3FJ@28211|Alphaproteobacteria,2K0W7@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_605491_1 1198452.Jab_2c15860 1.12e-15 76.3 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,2VKQ5@28216|Betaproteobacteria,476ZU@75682|Oxalobacteraceae 28216|Betaproteobacteria L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_962483_1 1123354.AUDR01000012_gene1602 1.91e-105 313.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,2VK51@28216|Betaproteobacteria,1KSTD@119069|Hydrogenophilales 119069|Hydrogenophilales L CRISPR-associated protein Cas7 - - - - - - - - - - - - Cas_Cas7 k59_785059_1 338969.Rfer_3763 1.74e-64 202.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2VR6A@28216|Betaproteobacteria,4ADUW@80864|Comamonadaceae 28216|Betaproteobacteria S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_785059_2 296591.Bpro_0308 3.71e-18 83.6 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,2WGPI@28216|Betaproteobacteria,4AD4A@80864|Comamonadaceae 28216|Betaproteobacteria T LapD/MoxY periplasmic domain - - - - - - - - - - - - EAL,GGDEF,HAMP,LapD_MoxY_N k59_962671_1 1121957.ATVL01000006_gene2895 4.31e-79 248.0 COG0457@1|root,COG0457@2|Bacteria,4PJMD@976|Bacteroidetes,47NY2@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_19,TPR_21 k59_785175_1 476272.RUMHYD_02146 4.62e-42 150.0 COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,3XYRQ@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_962833_1 1121035.AUCH01000009_gene868 9.48e-115 348.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,2KV81@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_636703_1 883126.HMPREF9710_01092 3.81e-42 152.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,2VPEG@28216|Betaproteobacteria,472QT@75682|Oxalobacteraceae 28216|Betaproteobacteria C Protein of unknown function (DUF4080) - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_636703_2 373994.Riv7116_4252 8.38e-07 52.0 COG0745@1|root,COG0745@2|Bacteria,1FZYI@1117|Cyanobacteria,1HMAZ@1161|Nostocales 1117|Cyanobacteria T PFAM response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - DUF4388,Response_reg k59_962887_1 358220.C380_04780 2.14e-05 46.2 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,4A9Z3@80864|Comamonadaceae 28216|Betaproteobacteria I phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_962887_2 614083.AWQR01000020_gene197 4.07e-57 183.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,4AA1H@80864|Comamonadaceae 28216|Betaproteobacteria H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_721280_5 279238.Saro_3025 1.35e-12 65.1 2C58H@1|root,32YYI@2|Bacteria,1N7UA@1224|Proteobacteria,2UHCE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S NinB protein - - - - - - - - - - - - NinB k59_190410_1 1000565.METUNv1_02142 1.17e-38 144.0 COG4254@1|root,COG4254@2|Bacteria,1PGBS@1224|Proteobacteria,2VQEE@28216|Betaproteobacteria,2M02Z@206389|Rhodocyclales 206389|Rhodocyclales S FecR protein - - - - - - - - - - - - FecR k59_577363_3 443152.MDG893_10236 6.92e-118 377.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,1RN4X@1236|Gammaproteobacteria,46593@72275|Alteromonadaceae 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topB GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0006139,GO:0006259,GO:0006265,GO:0006310,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0022402,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0051304,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim k59_219504_1 1000565.METUNv1_04045 8.25e-140 446.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_43931_1 640081.Dsui_0971 1.05e-119 359.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales 206389|Rhodocyclales I poly(R)-hydroxyalkanoic acid synthase - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_1083296_1 269482.Bcep1808_3239 7.99e-10 59.3 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2VKKT@28216|Betaproteobacteria,1K1WU@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_1083296_2 1121935.AQXX01000096_gene2537 1.16e-93 288.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,1RZZW@1236|Gammaproteobacteria,1XQJH@135619|Oceanospirillales 135619|Oceanospirillales OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_114162_1 62928.azo0383 5.85e-21 89.4 COG4221@1|root,COG4221@2|Bacteria,1QTVZ@1224|Proteobacteria,2WGPF@28216|Betaproteobacteria,2KZNP@206389|Rhodocyclales 206389|Rhodocyclales S KR domain - - - - - - - - - - - - adh_short k59_654951_1 981336.F944_02894 1.41e-20 92.4 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,3NJM1@468|Moraxellaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_654951_2 1122951.ATUE01000008_gene87 1.1e-36 127.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,3NNII@468|Moraxellaceae 1236|Gammaproteobacteria U Preprotein translocase subunit YajC yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_1083314_1 1268303.RHODMAR_1846 9.39e-62 200.0 COG0596@1|root,COG0596@2|Bacteria,2I2P1@201174|Actinobacteria,4G9E2@85025|Nocardiaceae 201174|Actinobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_541977_1 640081.Dsui_0265 2.39e-64 213.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,2KV8V@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K07649 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_863481_1 402626.Rpic_4339 1.33e-38 138.0 COG3595@1|root,COG3595@2|Bacteria,1N8NB@1224|Proteobacteria,2VS2U@28216|Betaproteobacteria,1KEY5@119060|Burkholderiaceae 28216|Betaproteobacteria S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_577377_1 1000565.METUNv1_00374 1.54e-86 280.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KUIP@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_43946_1 1165096.ARWF01000001_gene390 2.36e-66 205.0 COG2323@1|root,COG2323@2|Bacteria,1RATW@1224|Proteobacteria,2VTFY@28216|Betaproteobacteria,2KNCY@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function (DUF421) - - - - - - - - - - - - DUF421 k59_970081_1 414684.RC1_0459 4.66e-56 180.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria,2JPFC@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome c-type protein - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_258209_1 1286631.X805_00010 3.98e-32 121.0 COG4951@1|root,COG4951@2|Bacteria,1RE15@1224|Proteobacteria,2VSA8@28216|Betaproteobacteria,1KKWJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DNA primase small subunit - - - - - - - - - - - - - k59_79548_1 1121035.AUCH01000016_gene2210 3.47e-44 161.0 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,2WGPI@28216|Betaproteobacteria,2KUI8@206389|Rhodocyclales 206389|Rhodocyclales T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_79548_2 305700.B447_19094 4.55e-68 213.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2VR6A@28216|Betaproteobacteria,2KWI6@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_577381_1 748247.AZKH_2602 3.4e-76 236.0 COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,2VP74@28216|Betaproteobacteria,2KZYY@206389|Rhodocyclales 206389|Rhodocyclales K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 k59_863492_1 1348657.M622_16105 2.15e-210 588.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2VI7W@28216|Betaproteobacteria,2KZKT@206389|Rhodocyclales 206389|Rhodocyclales L Recombinase - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase k59_192136_1 236097.ADG881_2173 2.14e-39 139.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1XJVN@135619|Oceanospirillales 135619|Oceanospirillales NU Pilus assembly protein PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_192136_2 1122603.ATVI01000006_gene502 1.8e-05 48.5 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1X4XB@135614|Xanthomonadales 135614|Xanthomonadales NU assembly protein (PilN) pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_971000_2 1448139.AI20_01715 1.48e-59 187.0 COG0346@1|root,COG0346@2|Bacteria,1RGZ8@1224|Proteobacteria,1S66M@1236|Gammaproteobacteria,1Y62T@135624|Aeromonadales 135624|Aeromonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_1085155_1 1089547.KB913013_gene3818 2.02e-14 78.6 COG2373@1|root,COG3210@1|root,COG2373@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - 4.2.2.20,4.2.2.21 ko:K08961,ko:K12548,ko:K13735 ko05100,map05100 - - - ko00000,ko00001,ko01000 - - - Big_1,Big_3_5,CHU_C,DUF11,SWM_repeat,SdrD_B,SprB k59_656772_1 1117314.PCIT_10899 5.26e-25 106.0 COG0693@1|root,COG0693@2|Bacteria,1QWZE@1224|Proteobacteria,1RZ4U@1236|Gammaproteobacteria,2Q1UR@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4915) - - - - - - - - - - - - DUF4915 k59_935300_1 1000565.METUNv1_00993 1.77e-97 318.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_366699_1 1198452.Jab_1c00780 3.7e-87 286.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,476EW@75682|Oxalobacteraceae 28216|Betaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_1085160_2 1123393.KB891326_gene170 0.000665 41.6 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,1KRFF@119069|Hydrogenophilales 119069|Hydrogenophilales H Pterin binding enzyme - - - - - - - - - - - - Pterin_bind k59_1043924_1 1163617.SCD_n00571 9.02e-81 258.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria 28216|Betaproteobacteria NU type II secretion system protein E xcpR - - ko:K02454,ko:K02652,ko:K12276 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1009037_1 946483.Cenrod_1178 4.05e-51 176.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,4A9JV@80864|Comamonadaceae 28216|Betaproteobacteria M HlyD membrane-fusion protein of T1SS cyaD - - ko:K02022,ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_513536_1 1198452.Jab_2c10870 1.24e-31 122.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,472VD@75682|Oxalobacteraceae 28216|Betaproteobacteria P Cytochrome C and Quinol oxidase polypeptide I norB - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_513536_2 1198452.Jab_2c10860 3.51e-12 63.2 COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2VU41@28216|Betaproteobacteria,474JT@75682|Oxalobacteraceae 28216|Betaproteobacteria K Transcriptional regulator nsrR - - ko:K13771 ko05132,map05132 - - - ko00000,ko00001,ko03000 - - - Rrf2 k59_756849_2 1070319.CAGGBEG34_350029 2.69e-30 116.0 COG3935@1|root,COG3935@2|Bacteria,1N8GP@1224|Proteobacteria,2VUHE@28216|Betaproteobacteria 28216|Betaproteobacteria L DnaD domain protein - - - - - - - - - - - - - k59_192211_1 887062.HGR_12722 2.46e-112 340.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,4AAU8@80864|Comamonadaceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_334845_1 1121033.AUCF01000046_gene547 3.76e-106 330.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1085206_2 765911.Thivi_4042 3.66e-81 269.0 2EY8D@1|root,33RGX@2|Bacteria,1NTUD@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_473144_1 1267211.KI669560_gene1074 1.15e-37 145.0 COG2755@1|root,COG3525@1|root,COG2755@2|Bacteria,COG3525@2|Bacteria,4NF9Z@976|Bacteroidetes,1IVUQ@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 20, domain 2 - - - - - - - - - - - - Glyco_hydro_20,Glyco_hydro_20b k59_334888_1 1144312.PMI09_00809 2.23e-27 109.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U0JQ@28211|Alphaproteobacteria,4BCSI@82115|Rhizobiaceae 28211|Alphaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_902449_1 1177179.A11A3_03329 1.18e-23 98.6 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XH40@135619|Oceanospirillales 135619|Oceanospirillales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_902449_2 40373.F991_00389 3.83e-41 137.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,3NNXP@468|Moraxellaceae 1236|Gammaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_902449_3 1112209.AHVZ01000026_gene1470 0.000287 42.4 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3NIGW@468|Moraxellaceae 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1085252_1 877455.Metbo_0771 1.57e-28 115.0 2DZ6S@1|root,2N58Z@2157|Archaea,2Y579@28890|Euryarchaeota,23PUI@183925|Methanobacteria 183925|Methanobacteria M Glycosyltransferase family 10 (fucosyltransferase) C-term - - - - - - - - - - - - Glyco_transf_10 k59_656880_1 1268237.G114_12918 9.82e-36 134.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1Y3MF@135624|Aeromonadales 135624|Aeromonadales M secretion protein HlyD family - - - ko:K12532 ko02020,map02020 M00326 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1 - - HlyD_3 k59_722263_1 535289.Dtpsy_2672 1.99e-25 101.0 COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,4AB4K@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH k59_722263_2 296591.Bpro_1726 8.06e-46 155.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,4ACQQ@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_864684_1 1112274.KI911560_gene2392 8.01e-31 124.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_295965_1 29581.BW37_02131 5.82e-54 189.0 2DBTD@1|root,2ZAXA@2|Bacteria,1QUZ0@1224|Proteobacteria,2WGM9@28216|Betaproteobacteria,4791P@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4962) - - - - - - - - - - - - DUF4962,Hepar_II_III k59_902456_1 543728.Vapar_1970 8.95e-68 220.0 COG2312@1|root,COG2312@2|Bacteria,1MU2S@1224|Proteobacteria,2VHVE@28216|Betaproteobacteria,4ACY4@80864|Comamonadaceae 28216|Betaproteobacteria S Erythromycin esterase - - - - - - - - - - - - Erythro_esteras k59_115307_1 358220.C380_06190 7.54e-94 276.0 COG2963@1|root,COG2963@2|Bacteria,1N700@1224|Proteobacteria,2WEP0@28216|Betaproteobacteria 28216|Betaproteobacteria L Helix-turn-helix domain - - - ko:K07483 - - - - ko00000 - - - HTH_28 k59_115307_2 358220.C380_06185 3.39e-143 407.0 COG2801@1|root,COG2801@2|Bacteria,1PNRG@1224|Proteobacteria,2VN2H@28216|Betaproteobacteria,4AJ4Y@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_722265_1 887898.HMPREF0551_2131 5.93e-44 148.0 COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,1K28A@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM YaeQ family protein yaeQ - - - - - - - - - - - YaeQ k59_366770_1 1220582.RRU01S_22_00080 4.64e-23 100.0 COG0742@1|root,COG0742@2|Bacteria,1QW4K@1224|Proteobacteria,2TWMD@28211|Alphaproteobacteria,4BDG0@82115|Rhizobiaceae 28211|Alphaproteobacteria L ribosomal rna small subunit methyltransferase - - - - - - - - - - - - - k59_259414_1 614083.AWQR01000045_gene2044 1.48e-66 207.0 COG2413@1|root,COG2413@2|Bacteria,1RFTH@1224|Proteobacteria,2VJC9@28216|Betaproteobacteria,4AJW1@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_401999_1 1000565.METUNv1_02975 1.83e-40 150.0 COG1566@1|root,COG1566@2|Bacteria,1QVR9@1224|Proteobacteria,2W3A9@28216|Betaproteobacteria 28216|Betaproteobacteria V Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_4 k59_1009100_1 1122951.ATUE01000009_gene456 4.9e-114 343.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,3NJ1B@468|Moraxellaceae 1236|Gammaproteobacteria H acetolactate synthase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_578331_1 1000565.METUNv1_00385 4.89e-139 399.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,2KU94@206389|Rhodocyclales 206389|Rhodocyclales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_830746_1 614083.AWQR01000021_gene253 5.98e-57 186.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,4AAQZ@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_830746_2 614083.AWQR01000021_gene252 6.59e-32 119.0 28P0I@1|root,2ZBX5@2|Bacteria,1RB8U@1224|Proteobacteria,2VQ6K@28216|Betaproteobacteria,4AD57@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3025) - - - - - - - - - - - - DUF3025 k59_971085_1 1144319.PMI16_02944 3.03e-40 146.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,4737A@75682|Oxalobacteraceae 28216|Betaproteobacteria L A G-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_1085310_5 1223542.GM1_041_00390 1.32e-21 99.0 COG1074@1|root,COG1074@2|Bacteria,2ICR2@201174|Actinobacteria,4GG6F@85026|Gordoniaceae 201174|Actinobacteria L PDDEXK-like domain of unknown function (DUF3799) - - - - - - - - - - - - DUF3799 k59_410298_1 331869.BAL199_28435 3.59e-11 68.2 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,4BR5K@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain resE - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg,SSF k59_620366_1 1500894.JQNN01000001_gene2523 6.89e-102 305.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VZU7@28216|Betaproteobacteria 28216|Betaproteobacteria H Aminotransferase class I and II - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1018487_1 1000565.METUNv1_00401 2.37e-48 170.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales 206389|Rhodocyclales CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1018487_2 1000565.METUNv1_00400 6.84e-38 128.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2VSDV@28216|Betaproteobacteria,2KWQG@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_673199_1 864069.MicloDRAFT_00029490 1.04e-79 247.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2UBG9@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_125537_1 323261.Noc_2367 2.5e-66 220.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1WWGJ@135613|Chromatiales 135613|Chromatiales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_483998_1 614083.AWQR01000052_gene3413 7.49e-119 356.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,4AA94@80864|Comamonadaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_270141_1 338969.Rfer_1996 2.54e-34 133.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,4AC0C@80864|Comamonadaceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_270141_2 640512.BC1003_1297 1.56e-11 63.5 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,1K13G@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_805520_1 1209072.ALBT01000031_gene1810 5.74e-55 177.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S46K@1236|Gammaproteobacteria,1FHXW@10|Cellvibrio 1236|Gammaproteobacteria C Prokaryotic cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_377752_1 306281.AJLK01000102_gene3404 6.51e-21 92.0 COG0491@1|root,COG4529@1|root,COG0491@2|Bacteria,COG4529@2|Bacteria,1G0CZ@1117|Cyanobacteria,1JGYC@1189|Stigonemataceae 1117|Cyanobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,NAD_binding_9 k59_377752_2 996637.SGM_1551 1.04e-05 47.8 COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria 201174|Actinobacteria S protein conserved in bacteria csoR - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_1122853_1 338969.Rfer_0509 2.11e-26 106.0 COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,2VI30@28216|Betaproteobacteria,4AAB3@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase HAMP region domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1093283_1 1123504.JQKD01000032_gene4451 6.26e-32 120.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,4AAK8@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_1093283_2 614083.AWQR01000005_gene1046 5.32e-70 216.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,4AE7E@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_673270_1 535289.Dtpsy_2677 1.6e-72 240.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,4AAM8@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_270165_1 999141.GME_12524 6.31e-106 324.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XIG3@135619|Oceanospirillales 135619|Oceanospirillales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_89929_1 1165096.ARWF01000001_gene2018 2.02e-70 223.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,2KM7K@206350|Nitrosomonadales 206350|Nitrosomonadales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_307637_1 42256.RradSPS_2375 5.89e-06 50.1 COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,4CQKQ@84995|Rubrobacteria 84995|Rubrobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_731958_1 929556.Solca_2365 3.4e-09 63.2 COG1361@1|root,COG1520@1|root,COG2373@1|root,COG3291@1|root,COG4655@1|root,COG4932@1|root,COG4935@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG2373@2|Bacteria,COG3291@2|Bacteria,COG4655@2|Bacteria,COG4932@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1IWX2@117747|Sphingobacteriia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,PKD,SprB k59_586444_1 1265490.JHVY01000024_gene5020 5.16e-07 50.4 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0109 QRPTase_C,QRPTase_N k59_377772_1 1121035.AUCH01000002_gene1493 4.66e-116 345.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,2KUNN@206389|Rhodocyclales 206389|Rhodocyclales T ATPase related to phosphate starvation-inducible protein PhoH - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_89937_1 1276756.AUEX01000031_gene136 6.13e-10 55.8 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,4AE30@80864|Comamonadaceae 28216|Betaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_89937_2 1123504.JQKD01000008_gene5282 1.41e-60 186.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,4AEBX@80864|Comamonadaceae 28216|Betaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_89937_3 232721.Ajs_0281 2.39e-94 280.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,4AA4R@80864|Comamonadaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_673295_1 925409.KI911562_gene219 5.05e-05 45.4 COG0124@1|root,COG0124@2|Bacteria,4NE8N@976|Bacteroidetes,1IW4I@117747|Sphingobacteriia 976|Bacteroidetes J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_530104_1 1297865.APJD01000017_gene4291 1.43e-71 226.0 COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2U3AB@28211|Alphaproteobacteria,3JVN2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F N-terminal domain of ribose phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_270184_1 365044.Pnap_4588 1.16e-94 309.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE k59_765397_1 1000565.METUNv1_00639 4.49e-119 356.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,2KURJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_5,UVR,UvrC_HhH_N k59_55034_1 700598.Niako_1167 2.48e-96 288.0 COG0540@1|root,COG0540@2|Bacteria,4NFIU@976|Bacteroidetes,1IP8Y@117747|Sphingobacteriia 976|Bacteroidetes F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_943618_1 228410.NE2520 1.26e-86 274.0 COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,3724T@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA helicase - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecQ_Zn_bind k59_943618_2 748280.NH8B_1063 1.47e-54 183.0 COG0758@1|root,COG3266@1|root,COG0758@2|Bacteria,COG3266@2|Bacteria,1Q7YP@1224|Proteobacteria,2VQH2@28216|Betaproteobacteria 28216|Betaproteobacteria LU DNA recombination-mediator protein A - - - - - - - - - - - - DNA_processg_A k59_875613_1 338966.Ppro_0723 5.99e-30 123.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales 28221|Deltaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_840559_1 338969.Rfer_1374 0.000384 44.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,4ABIH@80864|Comamonadaceae 28216|Betaproteobacteria NT PFAM chemotaxis sensory transducer pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_840559_2 614083.AWQR01000029_gene2153 8.54e-88 261.0 COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria,4ADYW@80864|Comamonadaceae 28216|Betaproteobacteria NT PFAM CheW domain protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_1093313_1 640081.Dsui_2685 1.63e-56 181.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,2KWH8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_458744_2 1120977.JHUX01000003_gene1075 1.27e-19 90.1 COG3696@1|root,COG3696@2|Bacteria,1QU7Y@1224|Proteobacteria,1T1QE@1236|Gammaproteobacteria,3NJ6G@468|Moraxellaceae 1236|Gammaproteobacteria P Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_980874_1 313606.M23134_05406 5.22e-53 178.0 COG1215@1|root,COG1215@2|Bacteria,4PME9@976|Bacteroidetes,47Y2R@768503|Cytophagia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_377807_1 1163617.SCD_n00434 7e-39 148.0 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Metal-dependent hydrolase HDOD - - - - - - - - - - - - GAF_2,HDOD,Pkinase k59_695500_1 1245471.PCA10_24070 3.7e-11 63.2 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1S1G1@1236|Gammaproteobacteria,1YFQK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_695500_2 388051.AUFE01000047_gene2475 1.46e-36 132.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,1K3VF@119060|Burkholderiaceae 28216|Betaproteobacteria C Quinone oxidoreductase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_910938_1 640512.BC1003_2099 2.65e-09 57.8 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VN57@28216|Betaproteobacteria,1K0T4@119060|Burkholderiaceae 28216|Betaproteobacteria C Pfam Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_910938_2 1000565.METUNv1_01990 8.67e-84 255.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,2KY7R@206389|Rhodocyclales 206389|Rhodocyclales C Transketolase, pyrimidine binding domain - - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_765429_1 887898.HMPREF0551_0663 5.88e-19 89.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K1IY@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family rhlE1 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - - - - - - - - - - DEAD,Helicase_C k59_55069_1 365044.Pnap_0778 1.68e-98 317.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,4A9NT@80864|Comamonadaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_161752_1 1116472.MGMO_47c00220 1.12e-26 114.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1XF30@135618|Methylococcales 135618|Methylococcales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1057647_3 1280944.HY17_04665 1.08e-32 123.0 2FI5T@1|root,349YH@2|Bacteria,1P1M3@1224|Proteobacteria,2UVNQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_840609_1 265072.Mfla_2203 3.06e-07 50.8 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,2KKSP@206350|Nitrosomonadales 206350|Nitrosomonadales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_307734_1 1198452.Jab_1c18300 3.48e-79 254.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2VM87@28216|Betaproteobacteria,47405@75682|Oxalobacteraceae 28216|Betaproteobacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_530217_1 365046.Rta_09050 7.93e-92 275.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,4AA1T@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - FAA_hydrolase k59_18743_2 631362.Thi970DRAFT_03068 1.28e-126 377.0 COG0846@1|root,COG0846@2|Bacteria,1R5V1@1224|Proteobacteria,1RSJX@1236|Gammaproteobacteria 1236|Gammaproteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_353784_1 1340493.JNIF01000003_gene4196 2.12e-65 223.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_353786_2 1379701.JPJC01000242_gene1067 3.04e-15 80.5 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2KEIX@204457|Sphingomonadales 204457|Sphingomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,Response_reg k59_309606_1 1120977.JHUX01000004_gene2367 6.32e-105 319.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,3NIQS@468|Moraxellaceae 1236|Gammaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_766679_1 321846.PS417_08245 3.22e-35 130.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases ascD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0042602,GO:0052875,GO:0055114 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_209960_1 365044.Pnap_1574 6.77e-120 357.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria 28216|Betaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_733396_1 1229487.AMYW01000052_gene3172 2.06e-63 217.0 COG0178@1|root,COG0178@2|Bacteria,4NEHM@976|Bacteroidetes,1HXI7@117743|Flavobacteriia,2NUFG@237|Flavobacterium 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - AAA_21,ABC_tran k59_675812_1 1123278.KB893548_gene4659 2.03e-40 152.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,47KAC@768503|Cytophagia 976|Bacteroidetes MU PFAM WD40-like beta Propeller - - - - - - - - - - - - PD40 k59_1094274_1 234267.Acid_5336 9.2e-41 155.0 COG0642@1|root,COG0784@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,3Y3IC@57723|Acidobacteria 57723|Acidobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_20261_1 251221.35211835 4.83e-05 46.2 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_20261_2 1267535.KB906767_gene4612 8.33e-15 77.0 COG0577@1|root,COG0577@2|Bacteria 1267535.KB906767_gene4612|- V efflux transmembrane transporter activity - - - - - - - - - - - - - k59_675825_1 929556.Solca_0523 1.35e-46 174.0 COG0587@1|root,COG0587@2|Bacteria,4NFA0@976|Bacteroidetes,1IR52@117747|Sphingobacteriia 976|Bacteroidetes L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_127067_1 156889.Mmc1_1068 6.48e-18 82.4 29597@1|root,2ZSMJ@2|Bacteria,1RKTS@1224|Proteobacteria,2UYHH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3037) - - - - - - - - - - - - DUF3037 k59_127067_2 767434.Fraau_1097 4.07e-53 177.0 2CDR7@1|root,32TTG@2|Bacteria,1N18S@1224|Proteobacteria,1SC8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_733412_1 243090.RB3919 7.45e-43 161.0 COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXGT@203682|Planctomycetes 203682|Planctomycetes C heme-binding domain, Pirellula Verrucomicrobium type - - - - - - - - - - - - Cytochrom_C,DUF1080 k59_379711_1 641524.ADICYQ_1583 1.38e-72 242.0 COG3345@1|root,COG3345@2|Bacteria,4PMM4@976|Bacteroidetes,47Y4A@768503|Cytophagia 976|Bacteroidetes G alpha-galactosidase - - - - - - - - - - - - - k59_532671_1 640081.Dsui_2769 2.09e-95 310.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VMEI@28216|Betaproteobacteria,2KX67@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,Thiol-ester_cl k59_912361_1 414684.RC1_1571 1.14e-06 48.9 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,2JQ85@204441|Rhodospirillales 204441|Rhodospirillales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_912361_2 414684.RC1_1570 1.29e-37 127.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,2JT7G@204441|Rhodospirillales 204441|Rhodospirillales IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_912361_3 1121033.AUCF01000001_gene1977 7.98e-06 46.6 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,2JP9A@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_230318_1 506534.Rhein_0202 5.41e-26 102.0 2EIBZ@1|root,33C3B@2|Bacteria,1NKKJ@1224|Proteobacteria,1SPG5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_230318_2 1038867.AXAY01000029_gene1689 2.57e-35 133.0 COG4271@1|root,COG4916@1|root,COG4271@2|Bacteria,COG4916@2|Bacteria,1RM3P@1224|Proteobacteria,2U9BE@28211|Alphaproteobacteria 28211|Alphaproteobacteria K TIR domain - - - - - - - - - - - - TIR_2 k59_766724_1 1122621.ATZA01000041_gene2657 1.59e-26 103.0 2AE6H@1|root,3140B@2|Bacteria,4NSDV@976|Bacteroidetes,1ITQK@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_358728_1 700598.Niako_5074 6.35e-65 212.0 COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1IQZJ@117747|Sphingobacteriia 976|Bacteroidetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1000857_1 1000565.METUNv1_00877 2.4e-09 57.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,2KVKS@206389|Rhodocyclales 206389|Rhodocyclales C D-amino acid dehydrogenase dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_1000857_2 1000565.METUNv1_00878 2.8e-40 142.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,2KUG8@206389|Rhodocyclales 206389|Rhodocyclales G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_679447_1 102129.Lepto7375DRAFT_5325 4.47e-54 192.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria 1117|Cyanobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - DUF4118,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1036765_1 1000565.METUNv1_03016 2.42e-183 532.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,2KV6T@206389|Rhodocyclales 206389|Rhodocyclales K RNA binding - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_1036765_2 1000565.METUNv1_02978 3.1e-182 525.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2VI5K@28216|Betaproteobacteria,2KUD9@206389|Rhodocyclales 206389|Rhodocyclales P carbonic anhydrase ecaA - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase k59_644720_1 1000565.METUNv1_00691 1.77e-73 231.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria,2KW07@206389|Rhodocyclales 206389|Rhodocyclales S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_644720_2 266265.Bxe_B2951 1.67e-36 124.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1K98H@119060|Burkholderiaceae 28216|Betaproteobacteria K SMART Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1074265_1 1408164.MOLA814_00002 1.16e-70 223.0 COG2207@1|root,COG2207@2|Bacteria,1NDQ2@1224|Proteobacteria,2VXQC@28216|Betaproteobacteria 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - HTH_18 k59_395262_1 1000565.METUNv1_02142 1.9e-61 202.0 COG4254@1|root,COG4254@2|Bacteria,1PGBS@1224|Proteobacteria,2VQEE@28216|Betaproteobacteria,2M02Z@206389|Rhodocyclales 206389|Rhodocyclales S FecR protein - - - - - - - - - - - - FecR k59_395262_2 1000565.METUNv1_02141 8.34e-203 574.0 COG0457@1|root,COG0457@2|Bacteria,1P464@1224|Proteobacteria,2VMYZ@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF560) - - - - - - - - - - - - DUF560,TPR_19 k59_109245_1 1437425.CSEC_0407 1.52e-52 170.0 COG2050@1|root,COG2050@2|Bacteria,2JH75@204428|Chlamydiae 204428|Chlamydiae Q Domain of unknown function (DUF4442) - - - - - - - - - - - - DUF4442 k59_109245_2 1353529.M899_2252 1.2e-56 199.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2MSTB@213481|Bdellovibrionales,2WJ2C@28221|Deltaproteobacteria 213481|Bdellovibrionales E Peptidase M1 membrane alanine aminopeptidase pepN - 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,ERAP1_C,HEAT_2,Peptidase_M1 k59_324612_2 1392490.JHZX01000001_gene3019 3.24e-57 183.0 arCOG06889@1|root,32RJ7@2|Bacteria,4P0X7@976|Bacteroidetes,1I7C1@117743|Flavobacteriia 976|Bacteroidetes S MTH538 TIR-like domain (DUF1863) - - - - - - - - - - - - DUF1863 k59_823170_1 358220.C380_09245 5.83e-164 462.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2VHU3@28216|Betaproteobacteria,4ACS8@80864|Comamonadaceae 28216|Betaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 k59_572997_1 375286.mma_0156 5.35e-12 65.1 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,472UI@75682|Oxalobacteraceae 28216|Betaproteobacteria T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation ntrY - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8 k59_965745_1 1000565.METUNv1_00710 1.04e-70 215.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,2KW5U@206389|Rhodocyclales 206389|Rhodocyclales O FKBP-type peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_503123_1 1000565.METUNv1_03297 1.66e-81 270.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales 206389|Rhodocyclales KNT COG0643 Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_73242_1 153721.MYP_4438 1.85e-18 84.3 COG1846@1|root,COG1846@2|Bacteria,4NWHB@976|Bacteroidetes,47WKE@768503|Cytophagia 976|Bacteroidetes K helix_turn_helix multiple antibiotic resistance protein - - - ko:K06075 - - - - ko00000,ko03000 - - - MarR k59_109257_1 159087.Daro_1926 2.06e-97 286.0 COG0740@1|root,COG0740@2|Bacteria,1R9T1@1224|Proteobacteria,2VJWS@28216|Betaproteobacteria,2KXNI@206389|Rhodocyclales 206389|Rhodocyclales OU Clp protease - - - - - - - - - - - - CLP_protease k59_359658_1 1100720.ALKN01000018_gene1757 5.46e-14 72.8 COG0079@1|root,COG0079@2|Bacteria,1P8FM@1224|Proteobacteria,2VJA8@28216|Betaproteobacteria,4AAPW@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM aminotransferase, class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_359658_2 391735.Veis_4778 1.56e-32 125.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2VII5@28216|Betaproteobacteria,4AC9X@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_181731_1 1123504.JQKD01000023_gene178 1.45e-116 352.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,4A9X6@80864|Comamonadaceae 28216|Betaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_324633_1 614083.AWQR01000005_gene1171 1.74e-84 265.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4AAAX@80864|Comamonadaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1074297_1 1454004.AW11_02974 0.00037 43.9 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1KQC5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1074297_2 62928.azo0882 2.62e-43 155.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,2KU87@206389|Rhodocyclales 206389|Rhodocyclales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_216225_1 640081.Dsui_1622 3.71e-115 356.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KUQF@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - - k59_144977_1 1000565.METUNv1_01446 1.99e-92 284.0 COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,2VIB0@28216|Betaproteobacteria,2KWGI@206389|Rhodocyclales 206389|Rhodocyclales C formylmethanofuran dehydrogenase - - 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - - k59_216227_1 1000565.METUNv1_02299 5.48e-109 343.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VPB3@28216|Betaproteobacteria,2KVVY@206389|Rhodocyclales 206389|Rhodocyclales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_4,TPR_8 k59_324660_1 614083.AWQR01000018_gene1915 4.53e-102 303.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHND@28216|Betaproteobacteria,4ADJK@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033,ko:K12369 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_359681_2 1000565.METUNv1_01160 3.74e-95 284.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,2KV74@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_894891_1 1286093.C266_21559 7.76e-21 86.7 COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,2VVRU@28216|Betaproteobacteria,1KATX@119060|Burkholderiaceae 28216|Betaproteobacteria C Acylphosphatase acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_288223_1 1000565.METUNv1_03021 1.66e-13 69.3 COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,2VHS2@28216|Betaproteobacteria,2KVZT@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_288223_2 1000565.METUNv1_03020 1.49e-196 556.0 COG1566@1|root,COG1566@2|Bacteria,1QW95@1224|Proteobacteria,2WI8S@28216|Betaproteobacteria 28216|Betaproteobacteria V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2 k59_288223_3 1000565.METUNv1_03019 6.87e-71 218.0 COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,2VT2S@28216|Betaproteobacteria,2KXF3@206389|Rhodocyclales 206389|Rhodocyclales CO Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin k59_503165_1 1448139.AI20_07990 5.64e-71 225.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1Y4J4@135624|Aeromonadales 135624|Aeromonadales T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_324667_1 420662.Mpe_A1875 1.68e-75 246.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,1KITV@119065|unclassified Burkholderiales 28216|Betaproteobacteria V TIGRFAM type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_359684_1 666681.M301_2511 3.38e-05 45.1 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,2KM84@206350|Nitrosomonadales 206350|Nitrosomonadales U PFAM MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_359684_2 1000565.METUNv1_03394 2.92e-48 159.0 COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,2KXEC@206389|Rhodocyclales 206389|Rhodocyclales U Biopolymer transport protein - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_359684_3 1000565.METUNv1_03395 1.42e-19 85.5 COG3064@1|root,COG3064@2|Bacteria,1RKZU@1224|Proteobacteria,2WGP5@28216|Betaproteobacteria,2KZNR@206389|Rhodocyclales 206389|Rhodocyclales M TonB C terminal - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - TonB_2 k59_608489_1 1000565.METUNv1_03274 2.54e-106 317.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,2KU9H@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_608489_2 1216976.AX27061_3881 7.87e-20 86.3 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,3T2EI@506|Alcaligenaceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1037759_1 296591.Bpro_2052 1.46e-124 370.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,4AACA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_894895_1 1000565.METUNv1_03591 1.91e-150 435.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,2KURY@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_38368_1 663610.JQKO01000012_gene3226 2.71e-110 331.0 2BWV3@1|root,33RJ0@2|Bacteria,1NSGD@1224|Proteobacteria,2UPZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_38368_2 558884.JRGM01000131_gene517 1.75e-30 115.0 2EJV8@1|root,33DJW@2|Bacteria,1NIK0@1224|Proteobacteria,1SGMC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF3828 k59_324674_1 794903.OPIT5_23700 3.77e-13 68.6 COG0673@1|root,COG0673@2|Bacteria,46U48@74201|Verrucomicrobia 74201|Verrucomicrobia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_144989_1 498211.CJA_1396 2.19e-32 127.0 COG4254@1|root,COG4932@1|root,COG4254@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T4AQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - Calx-beta k59_144989_2 497321.C664_15803 7.5e-07 50.8 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,2WGPI@28216|Betaproteobacteria,2KX4H@206389|Rhodocyclales 206389|Rhodocyclales T LapD/MoxY periplasmic domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_645947_1 1123248.KB893337_gene2340 2.56e-34 124.0 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,1IQ5V@117747|Sphingobacteriia 976|Bacteroidetes D CobQ CobB MinD ParA nucleotide binding domain soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_645947_2 485918.Cpin_2032 1.63e-55 180.0 COG2220@1|root,COG2220@2|Bacteria,4NGD5@976|Bacteroidetes,1IRXP@117747|Sphingobacteriia 976|Bacteroidetes S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_573039_1 1358423.N180_17930 3.83e-17 83.6 COG3206@1|root,COG3206@2|Bacteria,4NH8F@976|Bacteroidetes,1INN0@117747|Sphingobacteriia 976|Bacteroidetes M lipopolysaccharide biosynthesis protein - - - - - - - - - - - - - k59_144991_1 614083.AWQR01000002_gene2989 8.73e-94 291.0 COG0457@1|root,COG0457@2|Bacteria,1NNCT@1224|Proteobacteria,2VK0Z@28216|Betaproteobacteria,4ACBW@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_8 k59_73272_1 864073.HFRIS_020446 4.05e-06 47.8 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,472XC@75682|Oxalobacteraceae 28216|Betaproteobacteria H ThiF family thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_73272_2 454957.IA64_00795 2.89e-08 57.8 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,1X3GH@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the GST superfamily gst7 - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N k59_894904_1 1000565.METUNv1_01927 1.81e-157 462.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_359695_1 582744.Msip34_0636 6.03e-06 47.4 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,2KMB2@206350|Nitrosomonadales 28216|Betaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_359695_2 582744.Msip34_1330 8.74e-35 122.0 2DZ0Y@1|root,34C2I@2|Bacteria,1Q9CW@1224|Proteobacteria,2W7ZM@28216|Betaproteobacteria,2KMZJ@206350|Nitrosomonadales 206350|Nitrosomonadales S EF-hand, calcium binding motif - - - - - - - - - - - - EF-hand_7 k59_466451_1 614083.AWQR01000007_gene360 7.79e-30 106.0 COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2VXTQ@28216|Betaproteobacteria,4AFDS@80864|Comamonadaceae 28216|Betaproteobacteria P Heavy metal transport detoxification protein copZ - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA k59_466451_2 622637.KE124774_gene2395 5.79e-12 66.2 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,36X3A@31993|Methylocystaceae 28211|Alphaproteobacteria P E1-E2 ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_144996_1 1198452.Jab_1c03310 6.7e-77 240.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,474G1@75682|Oxalobacteraceae 28216|Betaproteobacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - DUF3369,GGDEF,HD,HD_5,Response_reg k59_252571_2 1000565.METUNv1_02635 1.11e-144 412.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VNCG@28216|Betaproteobacteria,2KV2Y@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor motC - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_252571_3 1000565.METUNv1_02634 8.62e-162 454.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,2KUVX@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_858634_1 1000565.METUNv1_01919 2.07e-163 465.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,2KUR1@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_109308_1 1000565.METUNv1_00083 7.11e-127 369.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KUZZ@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase, nitrogen specific ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_894929_2 743722.Sph21_3037 2.3e-58 184.0 COG1956@1|root,COG1956@2|Bacteria,4NM6D@976|Bacteroidetes,1IS2U@117747|Sphingobacteriia 976|Bacteroidetes T GAF domain-containing protein msrC - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 k59_324713_1 237368.SCABRO_03491 3.69e-06 50.8 COG0097@1|root,COG0097@2|Bacteria,2IZ8X@203682|Planctomycetes 203682|Planctomycetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_288268_1 1000565.METUNv1_03512 1.6e-114 346.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,2KVJZ@206389|Rhodocyclales 206389|Rhodocyclales I carboxylase pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_645983_1 551115.Aazo_5205 5.27e-25 103.0 COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HMSA@1161|Nostocales 1117|Cyanobacteria H Belongs to the P-Pant transferase superfamily hetI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_645983_2 1000565.METUNv1_03577 6.42e-141 448.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,2KW0H@206389|Rhodocyclales 206389|Rhodocyclales Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Hexapep,PP-binding k59_680207_1 1000565.METUNv1_04006 4.12e-156 442.0 COG1639@1|root,COG1639@2|Bacteria,1R4P9@1224|Proteobacteria,2VPPP@28216|Betaproteobacteria,2KVX9@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_680207_2 1000565.METUNv1_04005 2.57e-37 135.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,2KUHR@206389|Rhodocyclales 206389|Rhodocyclales C glycolate oxidase iron-sulfur subunit glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_145006_1 1051501.AYTL01000004_gene3535 2.69e-11 71.2 COG1216@1|root,COG1216@2|Bacteria,1VATJ@1239|Firmicutes,4HCW0@91061|Bacilli,1ZFI5@1386|Bacillus 91061|Bacilli S COG0463 Glycosyltransferases involved in cell wall biogenesis epsJ GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K19427 - - - - ko00000,ko01000 - GT2 - Glycos_transf_2 k59_359720_1 1000565.METUNv1_00101 5.34e-106 325.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_823235_1 1504672.669785666 5.85e-80 252.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2VHFA@28216|Betaproteobacteria,4AAC9@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_2381_1 745411.B3C1_18051 5.55e-55 184.0 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RV34@1236|Gammaproteobacteria,1J897@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_1074393_1 614083.AWQR01000046_gene3335 3.82e-43 142.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria,4ADYF@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_1074393_2 614083.AWQR01000046_gene3334 8.97e-47 156.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,2VN5G@28216|Betaproteobacteria,4ADIY@80864|Comamonadaceae 28216|Betaproteobacteria NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_537443_2 517417.Cpar_1037 1.38e-17 76.3 2E3QA@1|root,32YN8@2|Bacteria,1FFJG@1090|Chlorobi 1090|Chlorobi M Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_537443_3 203122.Sde_1566 2.83e-13 68.6 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,468X3@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_503230_1 1000565.METUNv1_03505 1.73e-238 668.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria,2KVVX@206389|Rhodocyclales 206389|Rhodocyclales P COG0659 Sulfate permease and related transporters (MFS superfamily) sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1108643_2 1000565.METUNv1_02444 8.06e-124 358.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,2VIX1@28216|Betaproteobacteria,2KV29@206389|Rhodocyclales 206389|Rhodocyclales S NIF3 (NGG1p interacting factor 3) - - - - - - - - - - - - NIF3 k59_503236_1 243365.CV_2156 1.57e-66 220.0 COG2801@1|root,COG2801@2|Bacteria,1QWUR@1224|Proteobacteria,2VNEY@28216|Betaproteobacteria 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_73289_1 351016.RAZWK3B_07804 5.73e-10 72.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TY6Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria QU COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_859295_1 159087.Daro_0847 7.44e-69 220.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales 206389|Rhodocyclales M (Lipo)protein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_859295_2 522306.CAP2UW1_1372 1.42e-09 57.8 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,1KPQ5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_788880_1 1041607.K0KU11 8.96e-53 172.0 COG0522@1|root,KOG3301@2759|Eukaryota,38B77@33154|Opisthokonta,3NU1W@4751|Fungi,3QN05@4890|Ascomycota,3RSRX@4891|Saccharomycetes 4751|Fungi J to Saccharomyces cerevisiae RPS9B (YBR189W) and RPS9A (YPL081W) RPS9B GO:0000462,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006450,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016070,GO:0016072,GO:0019222,GO:0019538,GO:0019843,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0030684,GO:0030686,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032040,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112 - ko:K02997 ko03010,map03010 M00177 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_182811_1 1000565.METUNv1_00738 5.93e-84 254.0 2AG9C@1|root,316EV@2|Bacteria,1PXG0@1224|Proteobacteria,2WCW4@28216|Betaproteobacteria,2KXAC@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1044209_2 1209072.ALBT01000022_gene4163 1.67e-72 224.0 COG4430@1|root,COG4430@2|Bacteria,1RJGC@1224|Proteobacteria,1S853@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - DUF1801,OmdA k59_543339_1 448385.sce6806 1.51e-31 123.0 COG2996@1|root,COG2996@2|Bacteria,1MXC3@1224|Proteobacteria,42P2A@68525|delta/epsilon subdivisions,2WKAS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S S1 domain - - - ko:K00243 - - - - ko00000 - - - S1_2 k59_45354_1 76114.ebA5660 2.46e-107 328.0 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2VN3R@28216|Betaproteobacteria,2KXD1@206389|Rhodocyclales 206389|Rhodocyclales E Bacterial extracellular solute-binding proteins, family 5 Middle dppA - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1113943_2 1538295.JY96_02085 1.69e-88 274.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,1KJ8B@119065|unclassified Burkholderiales 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_115622_1 1000565.METUNv1_02456 4.85e-276 773.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - - - - - - - - - - GAF,T2SSE,T2SSE_N k59_335448_1 1000565.METUNv1_03435 6.09e-64 200.0 2DF7Q@1|root,33391@2|Bacteria,1NB8A@1224|Proteobacteria,2VWDS@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_220647_1 1000565.METUNv1_01918 1.48e-139 396.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,2KUWG@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_296353_1 497321.C664_09778 3.29e-91 285.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VKMW@28216|Betaproteobacteria,2KV2G@206389|Rhodocyclales 206389|Rhodocyclales I Poly-beta-hydroxybutyrate - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_865038_1 1121920.AUAU01000008_gene1629 4.93e-94 279.0 COG0664@1|root,COG0664@2|Bacteria,3Y4WU@57723|Acidobacteria 57723|Acidobacteria K Cyclic nucleotide-monophosphate binding domain - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_578585_1 596154.Alide2_0705 1.71e-94 288.0 COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2VIWN@28216|Betaproteobacteria,4AE8H@80864|Comamonadaceae 28216|Betaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_259744_1 1198452.Jab_1c25190 2.34e-43 152.0 COG1752@1|root,COG1752@2|Bacteria,1RD3A@1224|Proteobacteria,2VWW6@28216|Betaproteobacteria,476AE@75682|Oxalobacteraceae 28216|Betaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_473525_2 336407.RBE_0394 4.29e-28 110.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,47ET3@766|Rickettsiales 766|Rickettsiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_402293_1 686340.Metal_4021 7.16e-70 237.0 COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,1RQXN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L dEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,DUF559,Helicase_C k59_1085845_1 232721.Ajs_2814 1.93e-95 286.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,4AAWU@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_3 moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1085845_2 338969.Rfer_2530 2.56e-16 77.4 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,4A9TP@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_192882_1 1249627.D779_0031 2.36e-65 214.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria,1WW66@135613|Chromatiales 135613|Chromatiales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_831067_1 1000565.METUNv1_02651 6.89e-111 338.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,2KVUK@206389|Rhodocyclales 206389|Rhodocyclales N Belongs to the flagella basal body rod proteins family flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_367177_2 614083.AWQR01000030_gene2805 6.63e-16 75.9 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,4AAY2@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_296378_1 1122951.ATUE01000006_gene999 2.02e-99 302.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RN38@1236|Gammaproteobacteria,3NQ8R@468|Moraxellaceae 1236|Gammaproteobacteria I alpha/beta hydrolase fold phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_757183_1 700598.Niako_5685 4.8e-143 434.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1IRF8@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC k59_831074_1 1000565.METUNv1_02115 4.99e-108 341.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,2KUNX@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,Response_reg k59_514208_1 1000565.METUNv1_02545 1.08e-64 210.0 COG3087@1|root,COG3087@2|Bacteria,1RCA5@1224|Proteobacteria,2VTK8@28216|Betaproteobacteria,2KWVE@206389|Rhodocyclales 206389|Rhodocyclales D Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_865074_1 1254432.SCE1572_04030 7.89e-90 280.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales 28221|Deltaproteobacteria Q Phytoene dehydrogenase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_1009461_1 1000565.METUNv1_03653 8.2e-83 263.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,2KV4F@206389|Rhodocyclales 206389|Rhodocyclales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_757189_1 1000565.METUNv1_02133 6.54e-285 790.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KUN3@206389|Rhodocyclales 206389|Rhodocyclales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_1113981_1 1000565.METUNv1_00867 1.07e-101 319.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUQZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_296401_1 527002.yaldo0001_21170 1.61e-60 199.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,1RPSG@1236|Gammaproteobacteria,41F4E@629|Yersinia 1236|Gammaproteobacteria S Belongs to the UPF0324 family yeiH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cons_hypoth698 k59_46591_1 1000565.METUNv1_03253 7.35e-171 487.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KUSQ@206389|Rhodocyclales 206389|Rhodocyclales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_758219_1 1000565.METUNv1_01927 3.63e-46 165.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_758219_2 1000565.METUNv1_01926 2.28e-30 107.0 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2VVUH@28216|Betaproteobacteria,2KX71@206389|Rhodocyclales 206389|Rhodocyclales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_474766_1 1000565.METUNv1_04003 4.59e-59 196.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales 206389|Rhodocyclales C Glycolate oxidase subunit GlcD glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_474766_2 1318628.MARLIPOL_06779 3.65e-24 95.1 COG5642@1|root,COG5642@2|Bacteria,1N2DF@1224|Proteobacteria,1S93Q@1236|Gammaproteobacteria,4689N@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384,HTH_3 k59_194906_1 663610.JQKO01000010_gene2275 1.95e-64 218.0 COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3NA3Z@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_544653_1 1000565.METUNv1_00310 5.5e-13 67.0 2D5F0@1|root,32TIY@2|Bacteria,1N1FC@1224|Proteobacteria,2VYG3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_544653_2 1000565.METUNv1_00311 4.81e-143 407.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,2KVI8@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the MtfA family - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_866423_1 640512.BC1003_5769 3.94e-36 140.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1JZMH@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding - - 1.3.99.16 ko:K00256,ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1087722_1 358220.C380_17635 8.49e-99 297.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,4AD3Y@80864|Comamonadaceae 28216|Betaproteobacteria T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_116813_2 925409.KI911562_gene2673 3.71e-11 62.4 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,1IRN1@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1087729_2 1298593.TOL_1068 2.27e-15 79.0 COG0845@1|root,COG0845@2|Bacteria,1RE6W@1224|Proteobacteria,1S89W@1236|Gammaproteobacteria,1XPHJ@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - k59_81934_1 1000565.METUNv1_00836 2.69e-14 68.6 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,2KWCE@206389|Rhodocyclales 206389|Rhodocyclales J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_81934_2 1000565.METUNv1_00837 2.04e-89 276.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,2KVE3@206389|Rhodocyclales 206389|Rhodocyclales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_866438_1 1054213.HMPREF9946_04533 2.51e-72 236.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales 204441|Rhodospirillales E COG4166 ABC-type oligopeptide transport system, periplasmic component - - - ko:K13893 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_10186_1 987059.RBXJA2T_17177 2.67e-39 139.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,2VH67@28216|Betaproteobacteria,1KJHX@119065|unclassified Burkholderiales 28216|Betaproteobacteria L TatD related DNase yjjV - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_723886_1 1000565.METUNv1_01493 3.09e-118 358.0 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,2WGPI@28216|Betaproteobacteria,2KX4H@206389|Rhodocyclales 206389|Rhodocyclales T LapD/MoxY periplasmic domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_221743_1 391735.Veis_1176 9.31e-82 244.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2VTR1@28216|Betaproteobacteria,4AEI2@80864|Comamonadaceae 28216|Betaproteobacteria L DNA mismatch endonuclease Vsr vsr - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - DUF559,Vsr k59_221743_2 391735.Veis_1177 2.25e-09 57.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,4ADF5@80864|Comamonadaceae 28216|Betaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - DUF3883,Helicase_C,ResIII,SNF2_N k59_445400_1 391735.Veis_1185 0.0 889.0 28HBW@1|root,2Z7NV@2|Bacteria,1N8Z2@1224|Proteobacteria,2VITM@28216|Betaproteobacteria,4AC15@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1998) - - - - - - - - - - - - DUF1998 k59_474813_1 1000565.METUNv1_01947 1.14e-192 577.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales 206389|Rhodocyclales E glutamate synthase gls1 - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_194977_1 614083.AWQR01000030_gene2735 6.74e-151 432.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,4A9M0@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_866462_1 340.xcc-b100_2673 1.78e-47 162.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1X631@135614|Xanthomonadales 135614|Xanthomonadales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_866462_2 1137799.GZ78_11310 6.01e-53 176.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XHX5@135619|Oceanospirillales 135619|Oceanospirillales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_46653_1 1000565.METUNv1_01186 3.77e-215 600.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,2KV0K@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids dadX - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1010620_1 1240349.ANGC01000066_gene90 8.75e-06 47.4 COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4FUP9@85025|Nocardiaceae 201174|Actinobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_1010620_2 296591.Bpro_0761 5.84e-109 331.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,4ACHN@80864|Comamonadaceae 28216|Betaproteobacteria I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_687081_1 313598.MED152_05115 1.24e-63 206.0 COG0738@1|root,COG0738@2|Bacteria,4NHI6@976|Bacteroidetes,1I0HK@117743|Flavobacteriia 976|Bacteroidetes G MFS transporter - - - - - - - - - - - - MFS_1 k59_1115122_1 1000565.METUNv1_01336 3.68e-57 189.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,2KUMY@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1115122_2 159087.Daro_3930 1.28e-26 105.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,2KUD6@206389|Rhodocyclales 206389|Rhodocyclales M epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_297722_1 1538295.JY96_18305 3.58e-123 363.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2VHMG@28216|Betaproteobacteria,1KK8E@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nitrogenase molybdenum-iron protein, alpha nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_297722_2 1218076.BAYB01000013_gene2794 3.57e-21 89.7 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2VIK4@28216|Betaproteobacteria,1K3HY@119060|Burkholderiaceae 28216|Betaproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_687087_1 1000565.METUNv1_00388 2.27e-128 369.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,2KW1X@206389|Rhodocyclales 206389|Rhodocyclales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_659789_1 925409.KI911562_gene321 1.45e-13 68.9 COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1IPSM@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_116871_1 663610.JQKO01000016_gene1570 2.38e-22 95.5 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N9SJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_116871_2 104623.Ser39006_01987 1.41e-108 327.0 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,1RXZ3@1236|Gammaproteobacteria,402UP@613|Serratia 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_516362_1 1000565.METUNv1_02363 4.4e-141 428.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJX9@28216|Betaproteobacteria 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_3 k59_796814_1 375286.mma_0846 5.82e-61 189.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,2VSCI@28216|Betaproteobacteria,474K8@75682|Oxalobacteraceae 28216|Betaproteobacteria S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_723947_2 658187.LDG_5677 1.94e-09 60.8 COG1835@1|root,COG1835@2|Bacteria,1PGJS@1224|Proteobacteria,1SXK5@1236|Gammaproteobacteria,1JGG1@118969|Legionellales 118969|Legionellales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_261141_1 1000565.METUNv1_02795 9.95e-85 270.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,2KVAJ@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1115162_1 1123367.C666_01395 1.93e-08 55.1 COG1161@1|root,COG1161@2|Bacteria,1MV5H@1224|Proteobacteria,2VHAG@28216|Betaproteobacteria,2KVMC@206389|Rhodocyclales 206389|Rhodocyclales S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity - - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_1115162_2 1000565.METUNv1_00503 5.53e-64 210.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2VKX4@28216|Betaproteobacteria,2KWF7@206389|Rhodocyclales 206389|Rhodocyclales P PhoD-like phosphatase, N-terminal domain - - - - - - - - - - - - PhoD,PhoD_N k59_659821_1 1165096.ARWF01000001_gene2347 3.15e-56 181.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VYPK@28216|Betaproteobacteria,2KMQ0@206350|Nitrosomonadales 206350|Nitrosomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_659821_2 1387312.BAUS01000002_gene662 4.75e-20 87.8 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,2KKF6@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM NADH flavin oxidoreductase NADH oxidase - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_337613_1 977880.RALTA_A0051 2.58e-58 194.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,1K0ET@119060|Burkholderiaceae 28216|Betaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_337613_2 1000565.METUNv1_03177 2.78e-25 97.1 2C84F@1|root,334ZR@2|Bacteria,1N6VS@1224|Proteobacteria,2VWHA@28216|Betaproteobacteria,2KXJN@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_152977_1 272844.PAB0796 8.96e-22 98.6 COG0463@1|root,arCOG01385@2157|Archaea,2Y7SN@28890|Euryarchaeota,2456V@183968|Thermococci 183968|Thermococci M Glycosyl transferase family group 2 - - 2.4.1.335 ko:K21305 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_152977_2 189753.AXAS01000011_gene7525 1.9e-25 106.0 COG1215@1|root,COG1215@2|Bacteria,1R66B@1224|Proteobacteria,2U968@28211|Alphaproteobacteria,3K0BX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_152983_1 987059.RBXJA2T_16177 5.74e-16 76.3 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,1KJHT@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome D1 heme domain nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_903829_1 700598.Niako_5928 2.21e-82 258.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,1IQ23@117747|Sphingobacteriia 976|Bacteroidetes I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1010667_1 1000565.METUNv1_03346 9.88e-72 224.0 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,2VIDF@28216|Betaproteobacteria,2KUAV@206389|Rhodocyclales 206389|Rhodocyclales H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group - - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_1010667_2 1000565.METUNv1_03347 3.41e-61 198.0 COG0079@1|root,COG0079@2|Bacteria,1MXDP@1224|Proteobacteria,2VKTS@28216|Betaproteobacteria,2KU6R@206389|Rhodocyclales 206389|Rhodocyclales E COG0079 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase cobC - - ko:K02225 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002 - - - Aminotran_1_2 k59_972525_1 573370.DMR_10750 5.15e-07 50.4 COG0840@1|root,COG0840@2|Bacteria 2|Bacteria NT transmembrane signaling receptor activity - - 2.1.1.80,3.1.1.61 ko:K00575,ko:K03406,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - 4HB_MCP_1,CheB_methylest,CheR,CheR_N,GAF_2,GGDEF,HAMP,HATPase_c,MCPsignal,PAS_10,SpoIIE,dCache_1 k59_972525_2 1215092.PA6_018_00010 1.16e-28 112.0 2DBEP@1|root,2Z8SY@2|Bacteria,1N7YS@1224|Proteobacteria,1T0YI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_723978_1 1454004.AW11_03163 3.24e-29 105.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,1KQ1F@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_168516_1 365046.Rta_35420 7.19e-92 282.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4AAST@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Type II secretion system protein E gspE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_168516_2 983917.RGE_07950 4.1e-22 96.3 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,1KK85@119065|unclassified Burkholderiales 28216|Betaproteobacteria NU general secretion pathway protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_25227_1 1121033.AUCF01000008_gene5558 3.22e-20 89.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2JPEF@204441|Rhodospirillales 204441|Rhodospirillales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_25227_2 1121033.AUCF01000008_gene5557 7.99e-37 137.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,2JQY8@204441|Rhodospirillales 204441|Rhodospirillales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_277220_1 748247.AZKH_3035 1.66e-104 314.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KVQ4@206389|Rhodocyclales 206389|Rhodocyclales H Cys/Met metabolism PLP-dependent enzyme metB - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1097572_1 543728.Vapar_0852 8.38e-36 129.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VKRD@28216|Betaproteobacteria,4AABH@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1097572_2 1458275.AZ34_04415 5.08e-81 249.0 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2WEQ6@28216|Betaproteobacteria,4AD53@80864|Comamonadaceae 28216|Betaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034,ko:K13891 ko02010,ko02024,map02010,map02024 M00239,M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 - - BPD_transp_1,OppC_N k59_562261_1 1089547.KB913013_gene3944 5.21e-57 201.0 COG1874@1|root,COG2911@1|root,COG3209@1|root,COG3656@1|root,COG1874@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3656@2|Bacteria,4PKBQ@976|Bacteroidetes,47XXU@768503|Cytophagia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,SdrD_B,SprB k59_387760_1 84531.JMTZ01000045_gene1015 5.67e-28 115.0 COG1305@1|root,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,1SYRA@1236|Gammaproteobacteria,1XCSR@135614|Xanthomonadales 135614|Xanthomonadales E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core k59_387760_2 640081.Dsui_1255 4.4e-64 200.0 COG0662@1|root,COG0662@2|Bacteria,1RHRM@1224|Proteobacteria,2VSY4@28216|Betaproteobacteria,2KX04@206389|Rhodocyclales 206389|Rhodocyclales G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_1067922_1 1122951.ATUE01000005_gene2005 5.61e-80 242.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,1S24V@1236|Gammaproteobacteria,3NKFT@468|Moraxellaceae 1236|Gammaproteobacteria Q Methionine biosynthesis protein MetW metW - - - - - - - - - - - MetW k59_949410_2 159087.Daro_1698 2.28e-09 57.4 COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria,2KUG5@206389|Rhodocyclales 206389|Rhodocyclales I Alpha/beta hydrolase family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_25242_1 1122212.AULO01000007_gene2600 2.31e-19 93.2 COG2206@1|root,COG2206@2|Bacteria,1RGJH@1224|Proteobacteria,1S4PZ@1236|Gammaproteobacteria,1XR61@135619|Oceanospirillales 135619|Oceanospirillales T HD domain - - - - - - - - - - - - HD_5 k59_1129584_1 1121033.AUCF01000001_gene2041 2.86e-72 231.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2TS9S@28211|Alphaproteobacteria,2JRIY@204441|Rhodospirillales 204441|Rhodospirillales I long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_492087_1 1123393.KB891333_gene2622 5.6e-46 156.0 COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2VHEE@28216|Betaproteobacteria,1KRVC@119069|Hydrogenophilales 119069|Hydrogenophilales P Iron permease FTR1 family - - - - - - - - - - - - FTR1 k59_882845_2 469610.HMPREF0189_00556 1.92e-15 73.9 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,1KM3E@119065|unclassified Burkholderiales 28216|Betaproteobacteria P subunit of a heme lyase ccmH - - ko:K02200 - - - - ko00000 - - - CcmH k59_234652_1 1000565.METUNv1_02600 5.19e-94 290.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VMI4@28216|Betaproteobacteria,2KW0C@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_387790_1 1189619.pgond44_00180 4.62e-29 107.0 29D8R@1|root,3006P@2|Bacteria,4NNGD@976|Bacteroidetes,1I1Z8@117743|Flavobacteriia,4C3UH@83612|Psychroflexus 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1026219_1 1120977.JHUX01000003_gene1345 6.3e-32 121.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,3NJAD@468|Moraxellaceae 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1026219_2 1122951.ATUE01000008_gene93 3.81e-16 75.9 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,3NJAM@468|Moraxellaceae 1236|Gammaproteobacteria E Serine acetyltransferase, N-terminal cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0840 Hexapep,SATase_N k59_562302_2 627192.SLG_26820 1.52e-15 78.2 2ATW4@1|root,31JFC@2|Bacteria,1R3UU@1224|Proteobacteria,2U31C@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_168584_1 935565.JAEM01000043_gene1968 5.13e-87 272.0 COG0553@1|root,COG0553@2|Bacteria,1NC5H@1224|Proteobacteria,2TUTJ@28211|Alphaproteobacteria,2PXZD@265|Paracoccus 28211|Alphaproteobacteria L helicase superfamily c-terminal domain - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_848582_1 760117.JN27_03495 1.89e-22 99.4 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2VJE3@28216|Betaproteobacteria,472N1@75682|Oxalobacteraceae 28216|Betaproteobacteria L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_492130_1 614083.AWQR01000002_gene3013 5.09e-120 357.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,4AC85@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_168590_1 1121334.KB911074_gene2504 1.98e-21 97.4 COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,3WHY9@541000|Ruminococcaceae 186801|Clostridia P Belongs to the bacterial solute-binding protein 9 family adcA - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_416490_1 926562.Oweho_0144 1.5e-36 135.0 COG0760@1|root,COG0760@2|Bacteria,4PK4P@976|Bacteroidetes,1IEB5@117743|Flavobacteriia,2PC5K@246874|Cryomorphaceae 976|Bacteroidetes O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - - - - - - - - - - - k59_811837_1 1461693.ATO10_13889 5.31e-15 77.0 COG0664@1|root,COG0664@2|Bacteria,1NCGM@1224|Proteobacteria,2UDQX@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - cNMP_binding k59_771184_1 886379.AEWI01000014_gene1463 8.4e-19 80.9 COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes,2G1N8@200643|Bacteroidia,3XK5U@558415|Marinilabiliaceae 976|Bacteroidetes T Histidine kinase-like ATPase domain rsbW - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 k59_771184_2 1392488.JHZY01000004_gene2942 1.78e-28 107.0 COG0319@1|root,COG0319@2|Bacteria,4NS93@976|Bacteroidetes,1I2W7@117743|Flavobacteriia,2XJMD@283735|Leeuwenhoekiella 976|Bacteroidetes S Uncharacterized protein family UPF0054 ybeY - - - - - - - - - - - UPF0054 k59_387858_1 264198.Reut_B5035 3.99e-89 280.0 COG1082@1|root,COG3185@1|root,COG1082@2|Bacteria,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VP26@28216|Betaproteobacteria,1K0M4@119060|Burkholderiaceae 28216|Betaproteobacteria EG Glyoxalase bleomycin resistance protein dioxygenase - - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AP_endonuc_2,Glyoxalase,Glyoxalase_4,Glyoxalase_5 k59_316315_1 325777.GW15_0221310 1.41e-21 100.0 COG0697@1|root,COG0697@2|Bacteria,1RE9G@1224|Proteobacteria,1S8GF@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG spore germination dotA - - ko:K12202 - - - - ko00000,ko02044 3.A.7.9.1 - - DotA k59_492145_2 1000565.METUNv1_00908 8.19e-152 432.0 COG0780@1|root,COG2904@1|root,COG0780@2|Bacteria,COG2904@2|Bacteria,1MW0M@1224|Proteobacteria,2VINU@28216|Betaproteobacteria,2KUCU@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K06879 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF,QueF_N k59_168610_1 395495.Lcho_1017 5.57e-32 120.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2VI19@28216|Betaproteobacteria,1KK1Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria N flagellar motor switch protein fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_168610_2 1219031.BBJR01000034_gene2259 9.08e-08 57.8 COG1317@1|root,COG1317@2|Bacteria,1NMQE@1224|Proteobacteria,2VSQ0@28216|Betaproteobacteria,4AEPN@80864|Comamonadaceae 28216|Betaproteobacteria N flagellar assembly protein FliH fliH - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH k59_592448_1 160799.PBOR_22470 0.000184 42.7 COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,4ISIW@91061|Bacilli,2773U@186822|Paenibacillaceae 91061|Bacilli S tRNA synthetases class II (A) - - - - - - - - - - - - tRNA-synt_2c,tRNA_SAD k59_592448_2 1005048.CFU_3258 4.66e-29 110.0 COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VVTK@28216|Betaproteobacteria,4753V@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF937) - - - - - - - - - - - - DUF937 k59_61558_1 1144313.PMI10_01839 5.97e-104 325.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2P0E5@237|Flavobacterium 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_987621_1 614083.AWQR01000030_gene2795 7.54e-33 120.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,4A9Z6@80864|Comamonadaceae 28216|Betaproteobacteria D TIGRFAM Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_987623_1 980584.AFPB01000149_gene521 1.65e-43 147.0 COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia,406DD@61432|unclassified Flavobacteriaceae 976|Bacteroidetes I NUDIX domain idi - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_987623_2 1121875.KB907549_gene2117 2.47e-22 90.5 COG3000@1|root,COG3000@2|Bacteria,4NMA9@976|Bacteroidetes,1I1A9@117743|Flavobacteriia 976|Bacteroidetes I hydroxylase crtZ - 1.14.15.24 ko:K15746 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00372 R07530,R07558,R07559,R07561,R07562,R07568,R07569,R07570,R07572,R07851,R09747 RC00478,RC00704,RC02629 ko00000,ko00001,ko00002,ko01000 - - - FA_hydroxylase k59_416512_1 358220.C380_22370 1.69e-105 311.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,4AAM5@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_25311_1 929713.NIASO_13090 1.59e-34 131.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NIIR@976|Bacteroidetes,1IPF7@117747|Sphingobacteriia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_882938_1 382464.ABSI01000016_gene712 1.9e-63 215.0 COG1298@1|root,COG1298@2|Bacteria,46TTN@74201|Verrucomicrobia 74201|Verrucomicrobia N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_97472_1 614083.AWQR01000007_gene420 5.25e-33 121.0 COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,2VHF0@28216|Betaproteobacteria,4AAN1@80864|Comamonadaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - ko:K03717 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_97472_2 377629.TERTU_2649 2.63e-23 93.6 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,2PNHP@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Transcriptional regulator iscR GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_811869_1 522306.CAP2UW1_3450 1.84e-75 233.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,1KQXU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR1 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_848653_1 1348657.M622_12910 1.81e-100 298.0 COG0322@1|root,COG0322@2|Bacteria,1R5TC@1224|Proteobacteria,2VHTS@28216|Betaproteobacteria,2KXX3@206389|Rhodocyclales 206389|Rhodocyclales L Domain of unknown function (DUF4357) - - - - - - - - - - - - DUF4357 k59_318731_1 614083.AWQR01000007_gene400 2.91e-63 199.0 COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2VKNR@28216|Betaproteobacteria,4ACX5@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR polS - 1.1.1.140,1.1.1.304,1.1.1.76,1.1.99.21 ko:K00068,ko:K03366,ko:K08261 ko00051,ko00650,map00051,map00650 - R02855,R02925,R02946,R03707,R05607,R09078,R10505 RC00085,RC00102,RC00205,RC00525 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_318731_2 614083.AWQR01000007_gene401 5.53e-46 155.0 COG2207@1|root,COG2207@2|Bacteria,1NDY5@1224|Proteobacteria,2VIGE@28216|Betaproteobacteria,4AAWY@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18 k59_564194_2 1276756.AUEX01000025_gene2048 3.62e-15 73.6 28NT9@1|root,2ZBRZ@2|Bacteria,1RBYF@1224|Proteobacteria,2VQNC@28216|Betaproteobacteria,4ADMY@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_951050_1 614083.AWQR01000031_gene2569 1.69e-118 342.0 2CCFR@1|root,2Z7VF@2|Bacteria,1MXHU@1224|Proteobacteria,2VHMR@28216|Betaproteobacteria,4A9VF@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_27142_1 1316936.K678_06415 8.05e-05 46.6 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JRA4@204441|Rhodospirillales 204441|Rhodospirillales T PFAM histidine kinase, HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 k59_279386_1 1000565.METUNv1_01356 7.87e-108 320.0 COG0491@1|root,COG0491@2|Bacteria,1RDXA@1224|Proteobacteria,2VSBH@28216|Betaproteobacteria,2KWZP@206389|Rhodocyclales 206389|Rhodocyclales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_170686_1 204773.HEAR2325 3.18e-83 256.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2VIBF@28216|Betaproteobacteria,4792V@75682|Oxalobacteraceae 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component yejB - - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_99618_1 397945.Aave_4476 9.02e-78 244.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VKGK@28216|Betaproteobacteria,4AC95@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM phospholipase A1 pldA - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_63463_2 1000565.METUNv1_02000 7.17e-70 212.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,2KWF2@206389|Rhodocyclales 206389|Rhodocyclales J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_63463_3 1000565.METUNv1_02001 8.37e-24 99.8 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,2KUCJ@206389|Rhodocyclales 206389|Rhodocyclales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_989567_1 1454004.AW11_01798 5.94e-116 342.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,1KQJT@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metXS - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_134611_1 925409.KI911562_gene2077 4.97e-110 333.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,1IPCI@117747|Sphingobacteriia 976|Bacteroidetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_390916_1 66269.NL54_21240 3.15e-49 161.0 COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,1S8MI@1236|Gammaproteobacteria,3W2P2@53335|Pantoea 1236|Gammaproteobacteria O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity ynjA - - - - - - - - - - - CMD k59_564274_1 272568.GDI3823 8.01e-31 121.0 COG3170@1|root,COG3170@2|Bacteria,1R724@1224|Proteobacteria,2TWUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_1098872_1 1122951.ATUE01000007_gene619 1.18e-34 125.0 COG0584@1|root,COG0584@2|Bacteria,1RJ24@1224|Proteobacteria,1S6EE@1236|Gammaproteobacteria,3NJY5@468|Moraxellaceae 1236|Gammaproteobacteria C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_740193_1 1457393.AZ09_10815 1.79e-59 195.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2TVM9@28211|Alphaproteobacteria,2JRH9@204441|Rhodospirillales 204441|Rhodospirillales U TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbD - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_740193_2 1100721.ALKO01000017_gene1562 5.1e-12 63.9 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,4AD9Q@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM TonB family protein tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1028558_1 1500894.JQNN01000001_gene631 5.11e-32 124.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,472TS@75682|Oxalobacteraceae 28216|Betaproteobacteria D Ftsk_gamma ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1028558_2 1198452.Jab_1c22990 3.22e-53 174.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VQH0@28216|Betaproteobacteria,472W8@75682|Oxalobacteraceae 28216|Betaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_813489_1 366394.Smed_1622 5.81e-18 84.3 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2TQWR@28211|Alphaproteobacteria,4B95V@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family rci - - - - - - - - - - - Phage_integrase k59_918846_1 1201290.M902_0616 1.65e-33 120.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2MUAU@213481|Bdellovibrionales,2WPSJ@28221|Deltaproteobacteria 213481|Bdellovibrionales S Belongs to the UPF0178 family yaiI - - ko:K09768 - - - - ko00000 - - - DUF188 k59_918846_2 1232683.ADIMK_3751 3.34e-24 101.0 COG1765@1|root,COG1944@1|root,COG1765@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,1RN47@1236|Gammaproteobacteria,464WG@72275|Alteromonadaceae 1236|Gammaproteobacteria O redox protein, regulator of disulfide bond formation ycaO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047429,GO:0047693,GO:0071704,GO:1901564 - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO k59_236379_2 1122951.ATUE01000005_gene2216 7.36e-59 187.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,3NJ2H@468|Moraxellaceae 1236|Gammaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_27252_1 991.IW20_25475 3.66e-36 137.0 COG3209@1|root,COG5306@1|root,COG3209@2|Bacteria,COG5306@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia,2NSCF@237|Flavobacterium 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,Laminin_G_3,SprB k59_318869_1 1122951.ATUE01000005_gene1740 4.75e-45 160.0 COG0860@1|root,COG0860@2|Bacteria,1RJBG@1224|Proteobacteria,1RXF4@1236|Gammaproteobacteria,3NQ7X@468|Moraxellaceae 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_3 k59_99714_2 1000565.METUNv1_04040 1.1e-23 99.8 COG3746@1|root,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,2VNJT@28216|Betaproteobacteria 28216|Betaproteobacteria P Putative porin - - - - - - - - - - - - Porin_5 k59_1098902_1 748247.AZKH_3588 9.15e-07 47.8 COG0236@1|root,COG0236@2|Bacteria,1N83X@1224|Proteobacteria,2VW0V@28216|Betaproteobacteria,2KZB5@206389|Rhodocyclales 206389|Rhodocyclales IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_1098902_2 1000565.METUNv1_03780 6.35e-72 246.0 COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria,2WEH7@28216|Betaproteobacteria,2KY9X@206389|Rhodocyclales 206389|Rhodocyclales S Heparinase II/III-like protein - - - - - - - - - - - - DUF4962,Hepar_II_III,VanZ k59_813511_1 391735.Veis_1179 3.65e-210 622.0 COG1002@1|root,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,2VPJC@28216|Betaproteobacteria,4ADBT@80864|Comamonadaceae 28216|Betaproteobacteria V Type II restriction enzyme, methylase subunits - - - - - - - - - - - - - k59_418433_1 1198452.Jab_2c13800 2.24e-75 235.0 COG4177@1|root,COG4177@2|Bacteria,1QVYX@1224|Proteobacteria,2WEFF@28216|Betaproteobacteria,476JC@75682|Oxalobacteraceae 28216|Betaproteobacteria U Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_494841_1 1000565.METUNv1_01832 2.72e-111 328.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,2KVNC@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_772891_1 1000565.METUNv1_01006 5.85e-37 138.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VI9T@28216|Betaproteobacteria,2KVW2@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase B/oxoprolinase acxB - 6.4.1.6 ko:K10854 - - - - ko00000,ko01000 - - - Hydantoinase_B k59_772891_2 1000565.METUNv1_01005 1.04e-90 285.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,2KVFW@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase/oxoprolinase N-terminal region acxA - 6.4.1.6 ko:K10855 - - - - ko00000,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_647013_1 187272.Mlg_1842 1.69e-36 137.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_647013_2 85643.Tmz1t_3402 1.84e-13 69.7 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,2KUDJ@206389|Rhodocyclales 206389|Rhodocyclales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_1002232_1 153721.MYP_4526 5.29e-08 55.1 COG0142@1|root,COG0142@2|Bacteria,4NEGQ@976|Bacteroidetes,47JRS@768503|Cytophagia 976|Bacteroidetes H Belongs to the FPP GGPP synthase family idsA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_182770_1 296591.Bpro_2879 3.5e-26 102.0 COG4726@1|root,COG4726@2|Bacteria,1N7I4@1224|Proteobacteria,2VVZB@28216|Betaproteobacteria,4AG13@80864|Comamonadaceae 28216|Betaproteobacteria NU Pilus assembly protein PilX - - - - - - - - - - - - PilX_N k59_182770_2 1123020.AUIE01000026_gene4845 1.38e-11 63.2 COG4966@1|root,COG4966@2|Bacteria,1Q8WG@1224|Proteobacteria,1SX1P@1236|Gammaproteobacteria,1YK35@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NU Type IV Pilus-assembly protein W - - - - - - - - - - - - PilW k59_788859_1 1000565.METUNv1_02529 1.94e-119 375.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,2KUW5@206389|Rhodocyclales 206389|Rhodocyclales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_788859_2 1000565.METUNv1_02530 8.09e-87 257.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VQEB@28216|Betaproteobacteria,2KW7W@206389|Rhodocyclales 206389|Rhodocyclales S CBS domain - - - - - - - - - - - - CBS k59_788859_3 1000565.METUNv1_02531 1.3e-103 315.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,2KUXQ@206389|Rhodocyclales 206389|Rhodocyclales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_396260_1 385682.AFSL01000088_gene882 8.73e-74 232.0 COG0451@1|root,COG0451@2|Bacteria,4NDV4@976|Bacteroidetes,2FNA5@200643|Bacteroidia,3XJQK@558415|Marinilabiliaceae 976|Bacteroidetes GM RmlD substrate binding domain fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_680823_1 1000565.METUNv1_00355 1.33e-84 254.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VT9V@28216|Betaproteobacteria,2KZ02@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory proteins, crp family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_680823_2 1088868.CIN_08500 2.52e-12 66.2 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2JPU0@204441|Rhodospirillales 204441|Rhodospirillales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_647029_1 1000565.METUNv1_01896 6.97e-136 399.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW1@206389|Rhodocyclales 206389|Rhodocyclales JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_895821_1 1000565.METUNv1_02962 4.23e-73 228.0 2BUI5@1|root,32PUE@2|Bacteria,1RHFT@1224|Proteobacteria,2VT0W@28216|Betaproteobacteria,2KZHV@206389|Rhodocyclales 206389|Rhodocyclales S PEP-CTERM motif - - - - - - - - - - - - - k59_504205_1 1100721.ALKO01000027_gene348 1.56e-74 234.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AAD0@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_752328_2 1000565.METUNv1_00409 4.62e-54 171.0 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,2VVNX@28216|Betaproteobacteria,2KWYW@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_752328_3 1000565.METUNv1_00408 6.09e-44 145.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,2KW7M@206389|Rhodocyclales 206389|Rhodocyclales I Oligoketide cyclase lipid transport protein - - - - - - - - - - - - Polyketide_cyc k59_573720_2 237368.SCABRO_02397 4.1e-08 57.8 COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes 203682|Planctomycetes T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_289554_1 397945.Aave_3090 3.09e-19 86.7 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,4AB40@80864|Comamonadaceae 28216|Betaproteobacteria S DinB superfamily egtB - - - - - - - - - - - DinB_2,FGE-sulfatase k59_289554_2 1454004.AW11_03109 1.02e-32 122.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1KQ9G@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Histidine-specific methyltransferase, SAM-dependent egtD - - - - - - - - - - - Methyltransf_33 k59_824257_1 1000565.METUNv1_01592 2.79e-61 193.0 2E3EJ@1|root,32YDJ@2|Bacteria,1N8MS@1224|Proteobacteria,2VW4J@28216|Betaproteobacteria,2KXBM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_824257_2 1000565.METUNv1_01591 1.32e-207 581.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,2VH3D@28216|Betaproteobacteria,2KYI5@206389|Rhodocyclales 206389|Rhodocyclales S A domain family that is part of the cupin metalloenzyme superfamily. - - 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_3346_1 1000565.METUNv1_01988 1.97e-110 327.0 COG3199@1|root,COG3199@2|Bacteria,1R9QB@1224|Proteobacteria,2VKMP@28216|Betaproteobacteria 28216|Betaproteobacteria H PFAM ATP-NAD AcoX kinase acoX - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_74275_1 1005048.CFU_0430 1.13e-79 254.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,472XR@75682|Oxalobacteraceae 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_789197_2 1000565.METUNv1_02522 1.03e-83 250.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,2VSVZ@28216|Betaproteobacteria,2KYP1@206389|Rhodocyclales 206389|Rhodocyclales C Thioredoxin-like [2Fe-2S] ferredoxin - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - 2Fe-2S_thioredx k59_396693_1 1235457.C404_05600 2.13e-138 407.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,1K09J@119060|Burkholderiaceae 28216|Betaproteobacteria E Cysteine desulfurase sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_573918_1 321955.AAGP01000019_gene2316 2.73e-31 122.0 COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria,4FANW@85019|Brevibacteriaceae 201174|Actinobacteria M GtrA-like protein - - - - - - - - - - - - Glycos_transf_2,GtrA k59_326146_1 640081.Dsui_3480 9.85e-33 124.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,2KUZ2@206389|Rhodocyclales 206389|Rhodocyclales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_326146_2 1000565.METUNv1_03923 6.26e-109 339.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KUQF@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - - k59_504683_1 1458275.AZ34_02575 6.74e-119 348.0 COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,2VKER@28216|Betaproteobacteria,4ADW2@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1075908_1 572477.Alvin_2334 4.16e-42 163.0 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG2202@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_896246_1 582744.Msip34_1203 2.21e-129 377.0 COG0160@1|root,COG0160@2|Bacteria,1QTZ3@1224|Proteobacteria,2VHZE@28216|Betaproteobacteria,2KNKT@206350|Nitrosomonadales 206350|Nitrosomonadales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_467631_1 1231391.AMZF01000034_gene712 7.73e-09 53.1 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,3T4VG@506|Alcaligenaceae 28216|Betaproteobacteria T Belongs to the BolA IbaG family bolA - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_467631_2 1000565.METUNv1_00859 5.08e-51 162.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,2KX2V@206389|Rhodocyclales 206389|Rhodocyclales S YCII-related domain - - - ko:K09780 - - - - ko00000 - - - YCII k59_467631_3 1000565.METUNv1_00860 9.45e-114 329.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,2KVFB@206389|Rhodocyclales 206389|Rhodocyclales D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_752582_1 1000565.METUNv1_03258 1.37e-148 429.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,2KVKC@206389|Rhodocyclales 206389|Rhodocyclales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_752582_2 1000565.METUNv1_03257 1.2e-135 397.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KUBX@206389|Rhodocyclales 206389|Rhodocyclales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_289584_1 1000565.METUNv1_02982 2.12e-265 742.0 COG0515@1|root,COG2114@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,2KWHB@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein kinase domain - - - - - - - - - - - - DUF4384,Pkinase k59_859568_2 983917.RGE_10650 1.96e-06 48.5 2DRHC@1|root,33BRH@2|Bacteria,1NIPF@1224|Proteobacteria,2VXM1@28216|Betaproteobacteria 28216|Betaproteobacteria S tigrfam pep-cterm - - - - - - - - - - - - VPEP k59_681101_1 1000565.METUNv1_00929 6.19e-81 244.0 COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2VTCX@28216|Betaproteobacteria,2KWGZ@206389|Rhodocyclales 206389|Rhodocyclales S esterase of the alpha beta hydrolase fold - - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase k59_681101_2 1000565.METUNv1_00931 3.09e-10 59.3 COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,2KV40@206389|Rhodocyclales 206389|Rhodocyclales P COG1613 ABC-type sulfate transport system, periplasmic component - - - ko:K02048 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - SBP_bac_11 k59_573929_1 936053.I1BYH8 2.26e-61 219.0 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi,1GXN4@112252|Fungi incertae sedis 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_647596_1 1122951.ATUE01000005_gene1762 1.33e-79 246.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,3NIT9@468|Moraxellaceae 1236|Gammaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_504717_1 614083.AWQR01000028_gene3179 2.66e-96 285.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,4AAS2@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_717719_1 349965.yinte0001_12490 2.01e-63 220.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,41F5E@629|Yersinia 1236|Gammaproteobacteria T to COG2202 FOG PAS PAC domain of Yersinia UniRef RepID UPI00005F9950 - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_326179_1 1000565.METUNv1_02600 2.07e-178 511.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VMI4@28216|Betaproteobacteria,2KW0C@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_467648_1 1000565.METUNv1_03024 5.86e-05 48.1 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VJXE@28216|Betaproteobacteria,2KWG2@206389|Rhodocyclales 206389|Rhodocyclales S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_467648_2 1000565.METUNv1_03023 1.12e-122 370.0 COG4389@1|root,COG4389@2|Bacteria,1MWEH@1224|Proteobacteria,2VIZV@28216|Betaproteobacteria,2KUTK@206389|Rhodocyclales 206389|Rhodocyclales L Site-specific recombinase - - - - - - - - - - - - SpecificRecomb k59_110297_1 1000565.METUNv1_02281 2.56e-89 265.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,2KVMQ@206389|Rhodocyclales 206389|Rhodocyclales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_110297_2 1000565.METUNv1_02283 9.96e-31 108.0 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,2VVPT@28216|Betaproteobacteria,2KX85@206389|Rhodocyclales 206389|Rhodocyclales J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_183342_2 1000565.METUNv1_00369 2.51e-263 737.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KUDS@206389|Rhodocyclales 206389|Rhodocyclales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_183342_3 497321.C664_02695 1.24e-75 228.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,2KWB1@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_966676_1 1403819.BATR01000098_gene3267 1.53e-68 219.0 COG0042@1|root,COG0042@2|Bacteria,46TSS@74201|Verrucomicrobia,2ITU4@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - ko:K05541 - - - - ko00000,ko01000,ko03016 - - - Dus k59_647616_1 305900.GV64_12470 1.75e-08 54.7 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XMA6@135619|Oceanospirillales 135619|Oceanospirillales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_647616_2 1000565.METUNv1_02790 2.91e-101 312.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,2KU6I@206389|Rhodocyclales 206389|Rhodocyclales E extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_1002675_1 1123229.AUBC01000004_gene3018 1.06e-25 102.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,3JSP5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_183349_1 305700.B447_05223 4.91e-116 337.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,2KUH5@206389|Rhodocyclales 206389|Rhodocyclales J Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1039046_1 1144342.PMI40_02034 3.34e-92 287.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,472BD@75682|Oxalobacteraceae 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_216967_1 1000565.METUNv1_00867 2.29e-198 575.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUQZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_360899_1 1000565.METUNv1_00785 3.8e-103 304.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,2VKYR@28216|Betaproteobacteria,2KW1I@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HDOD k59_74354_1 1479237.JMLY01000001_gene1998 2.74e-25 106.0 COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,1RR49@1236|Gammaproteobacteria,467YG@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid panE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0036094,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_360902_1 498211.CJA_0022 1.57e-07 50.1 COG5642@1|root,COG5642@2|Bacteria,1N2DF@1224|Proteobacteria,1S93Q@1236|Gammaproteobacteria,1FII7@10|Cellvibrio 1236|Gammaproteobacteria S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384,HTH_3 k59_360902_2 1158756.AQXQ01000007_gene390 1.66e-88 269.0 28M8G@1|root,2ZAMM@2|Bacteria,1MVBT@1224|Proteobacteria,1RMAM@1236|Gammaproteobacteria,1X0EB@135613|Chromatiales 135613|Chromatiales S RES - - - - - - - - - - - - RES k59_573952_1 487316.BBNM01000003_gene951 3.61e-23 95.9 COG2135@1|root,COG2135@2|Bacteria,1N1E2@1224|Proteobacteria,1SA4R@1236|Gammaproteobacteria,3NJKX@468|Moraxellaceae 1236|Gammaproteobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_433302_1 1120977.JHUX01000004_gene2214 9.18e-66 216.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,3NJV9@468|Moraxellaceae 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_789250_1 395495.Lcho_1403 5.01e-07 50.4 COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2VMJD@28216|Betaproteobacteria,1KJRQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_789250_2 1123487.KB892863_gene1958 3.64e-23 89.7 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,2KWYD@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_467677_2 1538295.JY96_15135 6.12e-22 94.7 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VIY2@28216|Betaproteobacteria,1KPIM@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Glycosyltransferase like family 2 gtrB - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_752620_1 859657.RPSI07_2752 6.4e-41 149.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VGZY@28216|Betaproteobacteria,1JZQP@119060|Burkholderiaceae 28216|Betaproteobacteria K Regulatory protein GntR HTH - - - - - - - - - - - - Aminotran_1_2,GntR k59_3404_1 748247.AZKH_4103 6.84e-21 85.1 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,2VX71@28216|Betaproteobacteria 28216|Betaproteobacteria S May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_433309_1 203122.Sde_2529 7.12e-12 70.9 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,464D7@72275|Alteromonadaceae 1236|Gammaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_253820_1 358220.C380_11650 1.65e-20 86.3 COG0454@1|root,COG0456@2|Bacteria,1PFF9@1224|Proteobacteria,2W3TB@28216|Betaproteobacteria 28216|Betaproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_289641_1 159087.Daro_2811 2.32e-70 243.0 COG0642@1|root,COG0784@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,Response_reg k59_433323_2 929712.KI912613_gene1473 8.06e-17 82.8 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CRAY@84995|Rubrobacteria 201174|Actinobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9 k59_681149_1 1000565.METUNv1_02410 2.24e-08 54.3 2CG4C@1|root,2Z8MQ@2|Bacteria,1R6PQ@1224|Proteobacteria,2VHKG@28216|Betaproteobacteria,2KVNU@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_681149_2 1000565.METUNv1_02411 6.27e-84 258.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,2KU71@206389|Rhodocyclales 206389|Rhodocyclales NU type II secretion system protein - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_896332_1 983917.RGE_43290 2.82e-48 168.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,1KIXS@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_896332_2 1000565.METUNv1_00092 2.27e-09 58.2 COG0666@1|root,COG0666@2|Bacteria,1R76J@1224|Proteobacteria,2VP42@28216|Betaproteobacteria,2KV0E@206389|Rhodocyclales 206389|Rhodocyclales S Ankyrin repeat - - - - - - - - - - - - Ank_4 k59_289653_1 862908.BMS_0492 2.1e-71 236.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2MSUS@213481|Bdellovibrionales,2WIZF@28221|Deltaproteobacteria 213481|Bdellovibrionales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_74387_2 232721.Ajs_3626 2.51e-73 233.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,4ABMX@80864|Comamonadaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1039084_1 1000565.METUNv1_02233 2.43e-126 389.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY2@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_966710_1 477184.KYC_17192 1.43e-22 98.6 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,2VPEM@28216|Betaproteobacteria,3T6KQ@506|Alcaligenaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_966710_2 1120977.JHUX01000005_gene2709 1.4e-19 85.5 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,3NIYU@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N k59_326285_1 1041147.AUFB01000019_gene5566 5.95e-12 72.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_824364_1 864051.BurJ1DRAFT_4168 2.48e-44 151.0 COG3245@1|root,COG3245@2|Bacteria,1RCEB@1224|Proteobacteria,2VQIB@28216|Betaproteobacteria,1KNAQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,Cytochrome_CBB3 k59_824364_2 748247.AZKH_0332 1.77e-30 119.0 2CJJV@1|root,30VBX@2|Bacteria,1RGSF@1224|Proteobacteria,2VS5D@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_546113_1 1158292.JPOE01000005_gene1329 1.36e-80 247.0 COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,2VQ0Q@28216|Betaproteobacteria,1KMPM@119065|unclassified Burkholderiales 28216|Betaproteobacteria K FCD pdhR - - ko:K05799,ko:K14348 - - - - ko00000,ko03000 - - - FCD,GntR k59_476219_3 1005995.GTPT_1616 4.52e-23 95.1 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S6BA@1236|Gammaproteobacteria,4BVGV@82986|Tatumella 1236|Gammaproteobacteria G Phage lysozyme ybcS GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_1116515_1 305700.B447_01766 2.88e-74 242.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KV0U@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional activator of acetoin glycerol metabolism - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_725294_1 670307.HYPDE_41338 3.15e-07 52.4 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,3N66A@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_725294_2 1000565.METUNv1_02137 2.12e-102 301.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,2KWF4@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_339678_2 1000565.METUNv1_01451 3.84e-100 298.0 COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,2VMCD@28216|Betaproteobacteria,2KVCZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT mch - 3.5.4.27 ko:K01499 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03464 RC01870 ko00000,ko00001,ko00002,ko01000 - - - MCH k59_725301_1 1121875.KB907546_gene2362 8.63e-11 64.3 COG3876@1|root,COG3876@2|Bacteria,4NEXD@976|Bacteroidetes,1HWQT@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - DUF1343 k59_725301_2 103733.JNYO01000042_gene6079 1.02e-19 88.2 COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DZTG@85010|Pseudonocardiales 201174|Actinobacteria S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - DLH,Pribosyltran k59_518461_1 1353529.M899_2083 1.3e-47 164.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WJAM@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM ABC-3 protein - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_339700_1 1238450.VIBNISOn1_840024 1.82e-39 139.0 COG4689@1|root,COG4689@2|Bacteria,1N4IP@1224|Proteobacteria,1S0V0@1236|Gammaproteobacteria,1Y1EP@135623|Vibrionales 135623|Vibrionales Q Acetoacetate decarboxylase (ADC) - - 4.1.1.4 ko:K01574 ko00072,ko00640,ko01100,map00072,map00640,map01100 M00088 R01366 RC00040 ko00000,ko00001,ko00002,ko01000 - - - ADC k59_339700_2 926569.ANT_07980 8.37e-12 62.8 COG3631@1|root,COG3631@2|Bacteria,2G75M@200795|Chloroflexi 200795|Chloroflexi S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_197185_1 313606.M23134_04130 7.38e-54 191.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,47K4H@768503|Cytophagia 976|Bacteroidetes D Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_299208_1 232721.Ajs_0093 1.16e-131 390.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VJYJ@28216|Betaproteobacteria,4AAXJ@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein norR - - ko:K02584,ko:K12266 ko02020,ko05132,map02020,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_833564_1 1000565.METUNv1_01545 2.44e-79 249.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2VH0F@28216|Betaproteobacteria,2KVDH@206389|Rhodocyclales 206389|Rhodocyclales G ABC-type sugar transport system, periplasmic component - - - ko:K05813 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - SBP_bac_8 k59_118217_1 1005395.CSV86_24734 1.23e-60 199.0 COG4388@1|root,COG4388@2|Bacteria,1R5B8@1224|Proteobacteria,1RQUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Mu-like_Pro k59_725315_1 351348.Maqu_1143 6.42e-11 63.9 2EEZV@1|root,338SY@2|Bacteria,1NF4V@1224|Proteobacteria,1SFQH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_222930_1 1000565.METUNv1_03662 7.12e-57 182.0 29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,2VT0U@28216|Betaproteobacteria,2KZ3G@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_83253_1 640081.Dsui_0331 1.24e-45 164.0 COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,2VKGP@28216|Betaproteobacteria,2KVU6@206389|Rhodocyclales 206389|Rhodocyclales T Sigma factor PP2C-like phosphatases - - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - PAS,Response_reg,SpoIIE k59_341323_1 883126.HMPREF9710_04656 1.87e-24 97.4 COG1846@1|root,COG1846@2|Bacteria,1PC1E@1224|Proteobacteria,2WAKU@28216|Betaproteobacteria,477TE@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 k59_341323_2 1151122.AQYD01000006_gene2379 5.49e-22 95.1 COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4FN1I@85023|Microbacteriaceae 201174|Actinobacteria J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_198730_1 555793.WSK_3441 1.32e-47 167.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2U1Z2@28211|Alphaproteobacteria,2KDCD@204457|Sphingomonadales 204457|Sphingomonadales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_974729_1 1349767.GJA_4315 5.96e-85 275.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,472EF@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_938719_1 1121033.AUCF01000034_gene3522 3.48e-84 269.0 COG1216@1|root,COG1216@2|Bacteria,1R8ZG@1224|Proteobacteria,2UEWJ@28211|Alphaproteobacteria,2JXPR@204441|Rhodospirillales 204441|Rhodospirillales S Glycosyl transferase, family 2 - - - - - - - - - - - - - k59_477220_1 929713.NIASO_16335 1.71e-98 300.0 COG0056@1|root,COG0056@2|Bacteria,4NFZW@976|Bacteroidetes,1IP4E@117747|Sphingobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_663558_2 1121895.Q765_09815 1.77e-80 247.0 COG2207@1|root,COG2207@2|Bacteria,4NDYY@976|Bacteroidetes,1HYQB@117743|Flavobacteriia,2NU21@237|Flavobacterium 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_18 k59_799415_1 1175306.GWL_27000 4.77e-90 278.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,472KI@75682|Oxalobacteraceae 28216|Betaproteobacteria C PFAM FAD binding domain, FAD linked oxidases, C-terminal domain glcD2 - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_300254_1 926550.CLDAP_29120 5.38e-99 296.0 COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi 200795|Chloroflexi C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_371496_2 543728.Vapar_5133 3.99e-102 305.0 COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2VH99@28216|Betaproteobacteria,4ACXN@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM ABC transporter related - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_371496_3 595537.Varpa_5853 1.12e-81 252.0 COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VI9J@28216|Betaproteobacteria,4AD1K@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_155593_1 535289.Dtpsy_0058 8.45e-53 167.0 COG3512@1|root,COG3512@2|Bacteria,1N08B@1224|Proteobacteria,2VTET@28216|Betaproteobacteria,4AHR8@80864|Comamonadaceae 28216|Betaproteobacteria L CRISPR associated protein Cas2 cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k59_155593_2 535289.Dtpsy_0059 0.000142 43.1 COG1518@1|root,COG1518@2|Bacteria,1MX9W@1224|Proteobacteria,2VNWK@28216|Betaproteobacteria,4ACAR@80864|Comamonadaceae 28216|Betaproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_581435_1 1000565.METUNv1_00584 2.26e-47 159.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,2KUAR@206389|Rhodocyclales 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5,6.2.1.9 ko:K01902,ko:K08692 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_581435_2 1000565.METUNv1_00585 4.5e-48 172.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1047828_1 1121035.AUCH01000001_gene2039 3.94e-111 335.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,2KUQ9@206389|Rhodocyclales 206389|Rhodocyclales FP Exopolyphosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_1047844_1 216142.LT40_16220 1.19e-15 79.7 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria 1236|Gammaproteobacteria LU Rossmann fold nucleotide-binding protein involved in DNA uptake smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_300287_1 543728.Vapar_3307 7.3e-73 227.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VJFJ@28216|Betaproteobacteria,4ABTT@80864|Comamonadaceae 28216|Betaproteobacteria K LysR substrate-binding - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_726440_1 1226994.AMZB01000083_gene328 1.61e-33 128.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,1YCYX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Steryl acetyl hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_119340_1 1304883.KI912532_gene524 2.25e-09 59.7 COG4122@1|root,COG4122@2|Bacteria,1QWFV@1224|Proteobacteria,2WGYC@28216|Betaproteobacteria,2KZPR@206389|Rhodocyclales 206389|Rhodocyclales S O-methyltransferase activity - - - - - - - - - - - - - k59_263658_1 1000565.METUNv1_01096 5.24e-133 386.0 COG1960@1|root,COG1960@2|Bacteria,1MYT7@1224|Proteobacteria,2VIFP@28216|Betaproteobacteria,2KXXG@206389|Rhodocyclales 206389|Rhodocyclales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_520151_1 95619.PM1_0226620 4.71e-101 301.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_615681_1 1000565.METUNv1_02142 3.38e-59 198.0 COG4254@1|root,COG4254@2|Bacteria,1PGBS@1224|Proteobacteria,2VQEE@28216|Betaproteobacteria,2M02Z@206389|Rhodocyclales 206389|Rhodocyclales S FecR protein - - - - - - - - - - - - FecR k59_119347_1 1000565.METUNv1_02759 2.37e-28 113.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_49083_1 452637.Oter_4609 7.1e-64 216.0 COG1297@1|root,COG1297@2|Bacteria 2|Bacteria S iron-nicotianamine transmembrane transporter activity - - - - - - - - - - - - OPT k59_726476_1 614083.AWQR01000011_gene2383 5.43e-90 284.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAB0@80864|Comamonadaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase fadB2 - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_119374_1 397945.Aave_2807 7.77e-81 260.0 COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,2WGGE@28216|Betaproteobacteria,4AK0Q@80864|Comamonadaceae 28216|Betaproteobacteria M TonB-dependent receptor plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_49092_2 714943.Mucpa_6128 4.41e-17 75.1 COG0291@1|root,COG0291@2|Bacteria,4NUVR@976|Bacteroidetes,1IU0V@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_155657_1 700598.Niako_0980 7.41e-74 238.0 COG0469@1|root,COG0469@2|Bacteria,4NEEU@976|Bacteroidetes,1IPRW@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_905731_1 325777.GW15_0215805 3.31e-73 244.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1X4BR@135614|Xanthomonadales 135614|Xanthomonadales V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - ko:K13409 ko02010,ko04626,map02010,map04626 M00339 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_974807_1 887062.HGR_09610 2.11e-127 373.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,4AAS1@80864|Comamonadaceae 28216|Betaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_84202_1 159087.Daro_2730 8.75e-88 273.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,2KU7K@206389|Rhodocyclales 206389|Rhodocyclales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_12704_2 216432.CA2559_05285 5.44e-61 199.0 COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,1HWZU@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the thiolase family pcaF - - - - - - - - - - - Thiolase_C,Thiolase_N k59_726493_1 1163617.SCD_n01413 2.31e-127 393.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_3,PAS_9,Response_reg k59_300344_2 338969.Rfer_1734 6.84e-70 222.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,4AAA2@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 ko:K00646,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Ketoacyl-synt_C,ketoacyl-synt k59_341493_1 887062.HGR_02493 2.78e-39 130.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,2VTZ4@28216|Betaproteobacteria,4AEXE@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_341496_2 253839.SSNG_05642 4.33e-38 138.0 COG3396@1|root,COG3396@2|Bacteria,2I4XV@201174|Actinobacteria 201174|Actinobacteria S P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1012793_1 1163617.SCD_n00868 6.48e-74 229.0 COG4705@1|root,COG4705@2|Bacteria,1MVMJ@1224|Proteobacteria,2VJTM@28216|Betaproteobacteria 28216|Betaproteobacteria S Repeat of Unknown Function (DUF347) - - - - - - - - - - - - DUF347 k59_520262_1 743720.Psefu_3417 2.77e-67 229.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1YVZ6@136845|Pseudomonas putida group 1236|Gammaproteobacteria L DNA polymerase III alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_726513_1 266835.14021413 6.97e-24 105.0 2DRC3@1|root,33B6H@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_300361_1 1000565.METUNv1_01551 2.04e-159 460.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVA7@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_663743_1 1122951.ATUE01000007_gene543 2.3e-142 414.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,3NQU7@468|Moraxellaceae 1236|Gammaproteobacteria E HMGL-like leuA GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0066 HMGL-like,LeuA_dimer k59_726532_1 748247.AZKH_3166 3.55e-54 186.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,2KYK0@206389|Rhodocyclales 206389|Rhodocyclales J Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.14,6.4.1.8 ko:K01473,ko:K10701 ko00330,ko00642,ko01100,ko01120,ko01220,map00330,map00642,map01100,map01120,map01220 - R03187,R05453 RC00040,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_726532_2 748247.AZKH_3167 1.18e-48 157.0 COG4647@1|root,COG4647@2|Bacteria,1RD95@1224|Proteobacteria,2WBCP@28216|Betaproteobacteria,2KZ8X@206389|Rhodocyclales 206389|Rhodocyclales J Acetone carboxylase gamma subunit - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Acetone_carb_G k59_1117516_1 614083.AWQR01000029_gene2128 5.88e-158 455.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,4AAW8@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_12752_1 1177154.Y5S_02381 1.02e-39 149.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XHZK@135619|Oceanospirillales 135619|Oceanospirillales U Type II and III secretion system protein pilQ - - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_520317_1 83406.HDN1F_21380 2.21e-86 282.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5K5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138,ko:K18303 ko01501,ko01503,map01501,map01503 M00642,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.17 - - ACR_tran k59_1012825_1 365044.Pnap_2209 1.64e-66 218.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,4AC4P@80864|Comamonadaceae 28216|Betaproteobacteria FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_84255_1 1049564.TevJSym_cl00010 1.7e-51 180.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1,Thioredoxin_4 k59_547290_1 472759.Nhal_0735 3.98e-31 120.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K13041 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_547290_2 497321.C664_10118 1.12e-25 100.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,2KW2B@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_155739_2 443255.SCLAV_p0902 1.78e-10 64.7 COG4977@1|root,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_769457_1 1000565.METUNv1_02470 5.08e-101 305.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,2KU6P@206389|Rhodocyclales 206389|Rhodocyclales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_59632_1 384765.SIAM614_01761 1.1e-37 147.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate Guanylate cyclase cyaD - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_985483_2 243276.TPANIC_0448 6.97e-32 120.0 COG0035@1|root,COG0035@2|Bacteria,2J5NG@203691|Spirochaetes 203691|Spirochaetes F uracil phosphoribosyltransferase upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k59_130443_1 398578.Daci_1318 1.64e-14 79.0 COG0438@1|root,COG1216@1|root,COG2227@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1QP7Y@1224|Proteobacteria,2VMI5@28216|Betaproteobacteria,4AD1A@80864|Comamonadaceae 28216|Betaproteobacteria HM PFAM Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23 k59_130443_2 1086011.HJ01_01747 2.78e-18 85.5 COG1215@1|root,COG1215@2|Bacteria,4NIMF@976|Bacteroidetes,1I09D@117743|Flavobacteriia,2P0JE@237|Flavobacterium 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_233013_1 1028307.EAE_04475 3.76e-49 166.0 COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,1RMDJ@1236|Gammaproteobacteria,3X1TZ@547|Enterobacter 1236|Gammaproteobacteria Q Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate elbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009893,GO:0009987,GO:0019216,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045828,GO:0045834,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:0080090,GO:1901576 - - - - - - - - - - DJ-1_PfpI k59_489793_1 1122243.KB903776_gene1989 4.11e-105 331.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,3NIFC@468|Moraxellaceae 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_846252_1 946483.Cenrod_1807 1.65e-09 56.6 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,4AB1P@80864|Comamonadaceae 28216|Betaproteobacteria P phosphate transport regulator - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_846252_2 1223521.BBJX01000009_gene1216 1.7e-87 266.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,4AA1C@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM phosphate transporter pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1024038_1 1000565.METUNv1_00820 3.24e-50 163.0 2E6EI@1|root,33120@2|Bacteria,1NA6C@1224|Proteobacteria,2VW1M@28216|Betaproteobacteria,2KXGM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1065026_1 1283300.ATXB01000001_gene1516 3.15e-63 204.0 COG1216@1|root,COG1216@2|Bacteria,1PGWI@1224|Proteobacteria,1RXHY@1236|Gammaproteobacteria,1XGWQ@135618|Methylococcales 135618|Methylococcales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_23348_1 1268622.AVS7_01805 6.16e-48 157.0 COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2VT0A@28216|Betaproteobacteria,4AEH5@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein, MarR - - - - - - - - - - - - MarR,MarR_2 k59_23348_2 1100720.ALKN01000044_gene2052 2.32e-06 49.3 COG2050@1|root,COG2050@2|Bacteria,1RK46@1224|Proteobacteria,2VPWT@28216|Betaproteobacteria,4ADDQ@80864|Comamonadaceae 28216|Betaproteobacteria Q Thioesterase superfamily protein - - - - - - - - - - - - 4HBT k59_623948_1 595537.Varpa_5528 1.23e-24 102.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2VHSN@28216|Betaproteobacteria,4AAVS@80864|Comamonadaceae 28216|Betaproteobacteria O TIGRFAM type VI secretion ATPase, ClpV1 family clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_623948_2 1198452.Jab_2c19030 2.36e-52 172.0 COG3515@1|root,COG3515@2|Bacteria,1MY80@1224|Proteobacteria,2VN8Y@28216|Betaproteobacteria,473UQ@75682|Oxalobacteraceae 28216|Betaproteobacteria S ImpA, N-terminal, type VI secretion system impA - - ko:K11902 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - ImpA_N k59_130465_1 454957.IA64_08580 2.93e-25 102.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1X5YS@135614|Xanthomonadales 135614|Xanthomonadales CO Thiol disulfide interchange protein dsbE - - ko:K02199 - - - - ko00000,ko03110 - - - Redoxin k59_130465_2 264198.Reut_B4770 6.84e-13 67.4 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1K1P2@119060|Burkholderiaceae 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_384842_2 1123288.SOV_1c10770 0.00037 48.1 COG5434@1|root,COG5434@2|Bacteria,1VKFF@1239|Firmicutes,4H8U7@909932|Negativicutes 1239|Firmicutes M Right handed beta helix region - - - - - - - - - - - - Pectate_lyase_3 k59_489821_1 1005048.CFU_3721 1.2e-112 338.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,472BC@75682|Oxalobacteraceae 28216|Betaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_233037_1 1129794.C427_4655 3.41e-50 175.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,1RZ5Y@1236|Gammaproteobacteria,46A97@72275|Alteromonadaceae 1236|Gammaproteobacteria S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_880620_1 1385513.N780_14685 2.73e-37 144.0 COG0610@1|root,COG0610@2|Bacteria,1UIN3@1239|Firmicutes,4ITC7@91061|Bacilli,2YBXC@289201|Pontibacillus 91061|Bacilli V Z1 domain - - - - - - - - - - - - Z1 k59_880622_1 395493.BegalDRAFT_0539 3.34e-43 151.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM ATPase associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_384875_1 344747.PM8797T_21553 2.34e-94 288.0 COG0535@1|root,COG0535@2|Bacteria,2IX8N@203682|Planctomycetes 203682|Planctomycetes S enzyme of the MoaA nifB pqqE family - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_846296_1 1000565.METUNv1_02362 5.22e-38 145.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales 206389|Rhodocyclales T Type IV pili methyl-accepting chemotaxis transducer N-term - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3,PilJ k59_590701_1 1268240.ATFI01000005_gene4627 3.21e-06 51.6 COG0745@1|root,COG0745@2|Bacteria,4NE77@976|Bacteroidetes,2FMWQ@200643|Bacteroidia,4AN52@815|Bacteroidaceae 976|Bacteroidetes K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_559911_1 1000565.METUNv1_00578 6.24e-37 130.0 COG3404@1|root,COG3404@2|Bacteria,1R781@1224|Proteobacteria,2VUV6@28216|Betaproteobacteria 28216|Betaproteobacteria E Formiminotransferase-cyclodeaminase - - - - - - - - - - - - FTCD_C,HutD k59_166546_1 700598.Niako_4444 2.64e-37 143.0 COG1368@1|root,COG1368@2|Bacteria,4NFI9@976|Bacteroidetes,1IP53@117747|Sphingobacteriia 976|Bacteroidetes M PFAM sulfatase - - - - - - - - - - - - Sulfatase k59_95309_1 596154.Alide2_3860 2.2e-56 193.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,4A9JW@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_736433_1 1031711.RSPO_c00003 4.19e-63 213.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1K194@119060|Burkholderiaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_736433_2 883126.HMPREF9710_01072 5.85e-29 112.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,47303@75682|Oxalobacteraceae 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_130564_1 614083.AWQR01000046_gene3316 3.98e-64 214.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,4ABDS@80864|Comamonadaceae 28216|Betaproteobacteria N Belongs to the flagella basal body rod proteins family flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_384954_1 1000565.METUNv1_02725 3.44e-169 479.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,2KV2R@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC1 - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_384954_2 1000565.METUNv1_02724 5.06e-40 142.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,2KUSW@206389|Rhodocyclales 206389|Rhodocyclales E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_59752_1 1003200.AXXA_30417 6.47e-77 236.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,3T2S1@506|Alcaligenaceae 28216|Betaproteobacteria L NTP pyrophosphohydrolases including oxidative damage repair enzymes nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_414820_1 614083.AWQR01000020_gene197 1.5e-103 303.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,4AA1H@80864|Comamonadaceae 28216|Betaproteobacteria H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_414820_2 365046.Rta_31060 1.13e-18 79.7 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,2VQFF@28216|Betaproteobacteria,4ADT2@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM BLUF domain protein - - - - - - - - - - - - BLUF k59_915373_1 1000565.METUNv1_02556 3.27e-84 264.0 COG1639@1|root,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,2KVTS@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HDOD k59_1127660_1 1276756.AUEX01000009_gene1796 1.71e-56 187.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,4AC0J@80864|Comamonadaceae 28216|Betaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_947848_1 748247.AZKH_4078 8.51e-68 213.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2VIK4@28216|Betaproteobacteria,2KUME@206389|Rhodocyclales 206389|Rhodocyclales P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_276781_1 1179778.PMM47T1_06166 6.25e-38 138.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1S5KU@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Epimerase dehydratase - - - - - - - - - - - - Epimerase k59_916562_1 1504672.669786097 3.5e-25 101.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,4AB7Q@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_916562_2 595537.Varpa_4378 2.38e-47 162.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,4ABX2@80864|Comamonadaceae 28216|Betaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_416098_2 640081.Dsui_1738 9.08e-35 126.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2VRIC@28216|Betaproteobacteria,2KWEC@206389|Rhodocyclales 206389|Rhodocyclales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_61106_1 859657.RPSI07_3066 2.22e-68 221.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1K0BN@119060|Burkholderiaceae 28216|Betaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_949083_1 614083.AWQR01000009_gene697 1.01e-92 279.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,4A9SD@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_168120_1 1198452.Jab_1c06950 2.01e-127 385.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,2VKWR@28216|Betaproteobacteria,476I5@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_882320_1 640081.Dsui_2991 3.19e-78 257.0 COG0715@1|root,COG2199@1|root,COG0715@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WGZJ@28216|Betaproteobacteria,2KVQZ@206389|Rhodocyclales 206389|Rhodocyclales T NMT1/THI5 like - - - - - - - - - - - - GGDEF,NMT1,PAS_4 k59_1097354_1 522306.CAP2UW1_0858 1.83e-119 353.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VMX7@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family algD - 1.1.1.132 ko:K00066 ko00051,ko00520,ko02020,map00051,map00520,map02020 - R00880 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_168138_1 1000565.METUNv1_01613 3.22e-25 96.7 COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria,2VQ5F@28216|Betaproteobacteria,2KYRA@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide cynS - 4.2.1.104 ko:K01725 ko00910,map00910 - R03546,R10079 RC00952 ko00000,ko00001,ko01000 - - - Cyanate_lyase k59_1129216_1 983917.RGE_18390 9.91e-15 73.6 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria,1KJYK@119065|unclassified Burkholderiales 28216|Betaproteobacteria V ABC-2 family transporter protein yhhJ - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1129216_2 85643.Tmz1t_2841 6.23e-32 113.0 COG4691@1|root,COG4691@2|Bacteria,1N09T@1224|Proteobacteria,2VVBK@28216|Betaproteobacteria,2KZ82@206389|Rhodocyclales 206389|Rhodocyclales S Arc-like DNA binding domain - - - - - - - - - - - - - k59_1129216_3 765912.Thimo_2301 0.000186 42.0 COG4113@1|root,COG4113@2|Bacteria,1RIR6@1224|Proteobacteria,1SG9Z@1236|Gammaproteobacteria,1WZQV@135613|Chromatiales 135613|Chromatiales S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_811488_1 375286.mma_3420 3.88e-142 436.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,472V5@75682|Oxalobacteraceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1129219_1 1026882.MAMP_02114 2.04e-42 159.0 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,46089@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_561862_1 1198452.Jab_2c33150 3.96e-13 67.8 COG3591@1|root,COG3591@2|Bacteria,1MX71@1224|Proteobacteria,2WD27@28216|Betaproteobacteria,476KM@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 k59_561862_2 862514.HMPREF0623_1344 1.23e-34 124.0 COG0431@1|root,COG0431@2|Bacteria,1V282@1239|Firmicutes,4HHF5@91061|Bacilli,3F4MA@33958|Lactobacillaceae 91061|Bacilli S NADPH-dependent FMN reductase nqo1 - - ko:K19784 - - - - ko00000 - - - FMN_red k59_882379_2 159087.Daro_2311 1.52e-08 55.5 COG0741@1|root,COG0741@2|Bacteria,1MZU4@1224|Proteobacteria,2VU6M@28216|Betaproteobacteria,2KXCH@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_592113_1 1198452.Jab_2c31070 3.06e-40 137.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2W3CD@28216|Betaproteobacteria,4778T@75682|Oxalobacteraceae 28216|Betaproteobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA k59_592113_2 1235457.C404_21535 1.01e-49 165.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1K2NF@119060|Burkholderiaceae 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_882394_1 1182590.BN5_00934 9.69e-56 180.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1YJ9A@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_848144_1 614083.AWQR01000009_gene712 1.71e-33 126.0 COG2206@1|root,COG2206@2|Bacteria,1R3V1@1224|Proteobacteria,2WEX1@28216|Betaproteobacteria,4ACRV@80864|Comamonadaceae 28216|Betaproteobacteria T Metal dependent phosphohydrolase - - - - - - - - - - - - - k59_848144_2 614083.AWQR01000009_gene711 9.42e-22 88.6 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,4AE3J@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose aut - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_96999_1 1101189.AQUO01000001_gene2100 5.82e-23 94.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2PWFG@265|Paracoccus 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter cysA - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_96999_2 159087.Daro_0251 5.29e-77 238.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VIID@28216|Betaproteobacteria,2KVZ8@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1097387_1 375286.mma_0451 6.1e-29 110.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,475V5@75682|Oxalobacteraceae 28216|Betaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA soxA - - ko:K17222 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - - k59_1097387_2 375286.mma_0452 3.84e-90 269.0 COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2VP4W@28216|Betaproteobacteria,475FZ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome c soxX - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C k59_848152_1 1366050.N234_02495 9.9e-44 152.0 COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2VNEM@28216|Betaproteobacteria,1K5AJ@119060|Burkholderiaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_848152_2 1095769.CAHF01000013_gene3410 7.35e-23 96.3 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,4739I@75682|Oxalobacteraceae 28216|Betaproteobacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_416178_1 301.JNHE01000026_gene3109 5.33e-26 114.0 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YE8V@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 k59_625222_1 365044.Pnap_1260 4.23e-19 87.4 COG4454@1|root,COG5569@1|root,COG4454@2|Bacteria,COG5569@2|Bacteria,1R91G@1224|Proteobacteria,2VSDP@28216|Betaproteobacteria,4AED8@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Blue (type 1) copper domain - - - - - - - - - - - - Copper-bind,Cupredoxin_1,CusF_Ec k59_315854_1 1072685.IX83_07120 7.46e-51 177.0 COG0507@1|root,COG5362@1|root,COG0507@2|Bacteria,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2W8BI@28216|Betaproteobacteria,3T6FT@506|Alcaligenaceae 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_315854_2 1217652.F954_01169 8.24e-17 80.5 COG1917@1|root,COG1917@2|Bacteria,1P4U6@1224|Proteobacteria,1SUV8@1236|Gammaproteobacteria,3NP9A@468|Moraxellaceae 1236|Gammaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_701862_1 1192124.LIG30_3359 6.61e-40 134.0 COG0633@1|root,COG0633@2|Bacteria,1PQE9@1224|Proteobacteria,2VUDT@28216|Betaproteobacteria,1K8T3@119060|Burkholderiaceae 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_701862_2 748247.AZKH_4086 2.82e-60 186.0 COG1146@1|root,COG1146@2|Bacteria,1QW5F@1224|Proteobacteria,2WHBY@28216|Betaproteobacteria 28216|Betaproteobacteria C Ferredoxin III, nif-specific - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Fer4_7 k59_431754_2 688245.CtCNB1_2656 3.01e-30 139.0 COG0503@1|root,COG0827@1|root,COG3087@1|root,COG0503@2|Bacteria,COG0827@2|Bacteria,COG3087@2|Bacteria,1QZ6D@1224|Proteobacteria,2WI2K@28216|Betaproteobacteria,4AK49@80864|Comamonadaceae 28216|Betaproteobacteria DFL Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_1108678_1 477184.KYC_16587 1.26e-127 371.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,3T1TA@506|Alcaligenaceae 28216|Betaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_751756_1 130081.XP_005706457.1 1.24e-163 473.0 COG0649@1|root,KOG2870@2759|Eukaryota 2759|Eukaryota C quinone binding NDUFS2 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0005759,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010257,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019899,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031625,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070013,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K03935,ko:K06669 ko00190,ko01100,ko04110,ko04111,ko04113,ko04114,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04110,map04111,map04113,map04114,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko00535,ko01000,ko03036 3.D.1.6 - - Complex1_49kDa k59_751756_2 10181.XP_004851878.1 1.64e-52 181.0 COG0852@1|root,KOG1713@2759|Eukaryota,38BAK@33154|Opisthokonta,3B9TX@33208|Metazoa,3CTAV@33213|Bilateria,489WC@7711|Chordata,497AE@7742|Vertebrata,3J6NZ@40674|Mammalia,35MT5@314146|Euarchontoglires,4PT0P@9989|Rodentia 33208|Metazoa C NADH dehydrogenase ubiquinone iron-sulfur protein 3, mitochondrial NDUFS3 GO:0001558,GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0005759,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0007275,GO:0007568,GO:0008137,GO:0008150,GO:0008152,GO:0008340,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009966,GO:0009968,GO:0009987,GO:0010257,GO:0010259,GO:0010646,GO:0010648,GO:0010941,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016604,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0023051,GO:0023057,GO:0030308,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0040008,GO:0042773,GO:0042775,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0045926,GO:0046034,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048856,GO:0050136,GO:0050789,GO:0050794,GO:0051128,GO:0055086,GO:0055114,GO:0060548,GO:0065003,GO:0065007,GO:0070013,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0072593,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902531,GO:1902532,GO:1990204,GO:2001233,GO:2001234,GO:2001242,GO:2001243 1.6.5.3,1.6.99.3 ko:K03936 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1.6 - - Complex1_30kDa k59_751756_3 70448.Q0P3H5 1.76e-40 135.0 COG0838@1|root,KOG4662@2759|Eukaryota,37UUF@33090|Viridiplantae,34IGZ@3041|Chlorophyta 3041|Chlorophyta C Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone nad3 - 1.6.5.3 ko:K03880 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - Oxidored_q4 k59_1001682_1 748247.AZKH_2741 1.77e-31 118.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,2KVE7@206389|Rhodocyclales 206389|Rhodocyclales M peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 k59_1074465_1 1217718.ALOU01000019_gene2640 7.19e-92 292.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,1K2V1@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_503296_1 1244869.H261_16341 7.61e-96 315.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2770@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,dCache_1 k59_537479_1 1000565.METUNv1_01236 1.14e-174 496.0 COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,2KW5M@206389|Rhodocyclales 28216|Betaproteobacteria P Transcriptional regulator of molybdate metabolism, LysR family protein - - - - - - - - - - - - HTH_1,PBP_like k59_431782_1 1121033.AUCF01000044_gene4597 6.38e-56 197.0 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2JPRT@204441|Rhodospirillales 204441|Rhodospirillales M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_1037856_1 1000565.METUNv1_02910 1.14e-122 353.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,2KUPA@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome - - - - - - - - - - - - Cytochrom_C k59_1037856_2 1000565.METUNv1_02911 5.31e-150 427.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,2VIX0@28216|Betaproteobacteria,2KVCD@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF455) - - - - - - - - - - - - DUF455 k59_466549_1 1157708.KB907450_gene6307 1.34e-22 95.9 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,4AA22@80864|Comamonadaceae 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_466549_2 614083.AWQR01000011_gene2319 3.97e-27 109.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,4A9US@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_109388_1 1276756.AUEX01000006_gene3079 9.21e-22 85.9 2CIYF@1|root,3319J@2|Bacteria,1NA2J@1224|Proteobacteria,2VWH8@28216|Betaproteobacteria,4AFH4@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_109388_2 1157708.KB907457_gene2641 1.04e-111 326.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,4A9TQ@80864|Comamonadaceae 28216|Betaproteobacteria S ATPase associated with various cellular activities, AAA_5 - - - - - - - - - - - - AAA,AAA_5 k59_716714_1 1000565.METUNv1_00180 2.26e-62 199.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,2KU8H@206389|Rhodocyclales 206389|Rhodocyclales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_716714_2 713587.THITH_00965 1.76e-23 96.7 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Peptidyl-prolyl cis-trans fkpB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_716714_3 1000565.METUNv1_00178 6.52e-10 57.4 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,2KWMG@206389|Rhodocyclales 206389|Rhodocyclales M This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_2444_1 1000565.METUNv1_02968 2.25e-84 269.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,2KUGX@206389|Rhodocyclales 206389|Rhodocyclales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_895010_1 76869.PputGB1_3041 3.1e-22 98.6 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_680278_1 29581.BW37_03101 4.85e-22 87.4 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,474N4@75682|Oxalobacteraceae 28216|Betaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_324805_1 1000565.METUNv1_00503 1.32e-274 761.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2VKX4@28216|Betaproteobacteria,2KWF7@206389|Rhodocyclales 206389|Rhodocyclales P PhoD-like phosphatase, N-terminal domain - - - - - - - - - - - - PhoD,PhoD_N k59_324805_2 1000565.METUNv1_00501 6.5e-271 752.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2VH5R@28216|Betaproteobacteria,2KUU7@206389|Rhodocyclales 206389|Rhodocyclales S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_431798_1 1000565.METUNv1_00440 1.81e-157 468.0 COG1196@1|root,COG1196@2|Bacteria,1NGZ2@1224|Proteobacteria,2VIWY@28216|Betaproteobacteria,2KUZR@206389|Rhodocyclales 206389|Rhodocyclales D SMC domain-containing protein - - - - - - - - - - - - AAA_21,SMC_N k59_965873_1 1000565.METUNv1_02120 4e-116 348.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,2KVEZ@206389|Rhodocyclales 206389|Rhodocyclales M Outer membrane efflux protein - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_965873_2 1000565.METUNv1_02119 0.0 1043.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KUKW@206389|Rhodocyclales 206389|Rhodocyclales V AcrB/AcrD/AcrF family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_395440_2 1000565.METUNv1_03535 3.08e-100 299.0 COG1216@1|root,COG1216@2|Bacteria,1RB30@1224|Proteobacteria,2VQYN@28216|Betaproteobacteria,2KZHE@206389|Rhodocyclales 206389|Rhodocyclales H Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1001699_1 1255043.TVNIR_2230 2.32e-28 112.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_1001699_2 626418.bglu_2p1130 6.51e-61 202.0 COG0639@1|root,COG0639@2|Bacteria,1PXN4@1224|Proteobacteria 1224|Proteobacteria T COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - - - - - - - - - - Metallophos_2 k59_573137_1 272560.BPSL2248 2.14e-60 192.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,1K1SD@119060|Burkholderiaceae 28216|Betaproteobacteria E serine O-acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_573137_2 1000565.METUNv1_00558 3.96e-84 255.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2VI2D@28216|Betaproteobacteria,2KW30@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1037876_1 987059.RBXJA2T_14501 6e-18 79.7 COG3094@1|root,COG3094@2|Bacteria,1NPTP@1224|Proteobacteria,2VWBN@28216|Betaproteobacteria,1KMPT@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Invasion gene expression up-regulator, SirB - - - - - - - - - - - - SirB k59_1037876_2 338969.Rfer_0063 1.45e-26 99.8 COG1918@1|root,COG1918@2|Bacteria 2|Bacteria P iron ion homeostasis feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_1037876_3 1122604.JONR01000042_gene3475 3.91e-05 45.1 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1X3K4@135614|Xanthomonadales 135614|Xanthomonadales P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_2451_1 1000565.METUNv1_03066 9.76e-66 211.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KV06@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_2451_2 1000565.METUNv1_03067 3.97e-32 118.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_965877_2 1000565.METUNv1_03293 2.4e-93 277.0 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2VRA6@28216|Betaproteobacteria,2KWBF@206389|Rhodocyclales 206389|Rhodocyclales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_858730_1 886293.Sinac_3213 3.83e-47 170.0 COG4805@1|root,COG4805@2|Bacteria,2IXQZ@203682|Planctomycetes 203682|Planctomycetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_252693_1 391735.Veis_4125 1.24e-46 151.0 COG2944@1|root,COG2944@2|Bacteria,1PT1R@1224|Proteobacteria,2VW98@28216|Betaproteobacteria 28216|Betaproteobacteria K sequence-specific DNA binding - - - - - - - - - - - - - k59_1108714_1 391735.Veis_1179 2.27e-196 588.0 COG1002@1|root,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,2VPJC@28216|Betaproteobacteria,4ADBT@80864|Comamonadaceae 28216|Betaproteobacteria V Type II restriction enzyme, methylase subunits - - - - - - - - - - - - - k59_181953_1 927677.ALVU02000008_gene51 8.24e-30 118.0 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,1G345@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA k59_181953_2 1000565.METUNv1_00899 4.67e-99 296.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2VQK6@28216|Betaproteobacteria,2KW9M@206389|Rhodocyclales 206389|Rhodocyclales S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_181953_3 1000565.METUNv1_00900 5.54e-39 132.0 2EPNT@1|root,33H9E@2|Bacteria,1NI6Z@1224|Proteobacteria,2VXVE@28216|Betaproteobacteria,2KZ8W@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4936) - - - - - - - - - - - - DUF4936 k59_181953_4 1000565.METUNv1_00901 1.66e-163 465.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,2KVRU@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_2463_1 887062.HGR_12192 1.98e-107 337.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,4A9NR@80864|Comamonadaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1037883_1 1000565.METUNv1_01043 5.6e-235 671.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,2KVU2@206389|Rhodocyclales 206389|Rhodocyclales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1037883_2 1000565.METUNv1_01042 1.52e-81 248.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,2VH67@28216|Betaproteobacteria,2KV6C@206389|Rhodocyclales 206389|Rhodocyclales L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_646145_1 1120977.JHUX01000003_gene1350 1.55e-97 296.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,3NJ6Z@468|Moraxellaceae 1236|Gammaproteobacteria E Aminotransferase alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_324848_2 365044.Pnap_2305 3.75e-64 210.0 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2VTUB@28216|Betaproteobacteria,4AHWC@80864|Comamonadaceae 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_965893_1 118166.JH976537_gene2033 2.7e-21 97.8 COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1G3AY@1117|Cyanobacteria,1H9Q2@1150|Oscillatoriales 1117|Cyanobacteria P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp,cNMP_binding k59_537526_1 1454004.AW11_01495 5.48e-107 313.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,1KPRR@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_2479_1 519989.ECTPHS_04438 5.65e-67 236.0 COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2SI@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_466589_1 1000565.METUNv1_04043 1.73e-263 734.0 2B14X@1|root,31TIS@2|Bacteria,1RM4A@1224|Proteobacteria,2VT75@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - PBP_like_2 k59_466589_2 1502770.JQMG01000001_gene2394 1.7e-21 98.2 2BHT9@1|root,32BWX@2|Bacteria,1P5DH@1224|Proteobacteria,2W560@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_823335_1 1415779.JOMH01000001_gene3190 1.4e-71 225.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria 1236|Gammaproteobacteria H synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_73352_1 1000565.METUNv1_02597 6.15e-131 401.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,2KUJ4@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1001731_1 1000565.METUNv1_00055 3.65e-104 314.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,2KUWY@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the mannose-6-phosphate isomerase type 2 family algA - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_38554_1 1269813.ATUL01000024_gene688 5.02e-06 52.8 COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,1S2PQ@1236|Gammaproteobacteria,1WZW0@135613|Chromatiales 135613|Chromatiales GM DoxX-like family - - - - - - - - - - - - DoxX_3,NAD_binding_10 k59_538145_2 1000565.METUNv1_00111 9.43e-232 672.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,2KUEK@206389|Rhodocyclales 206389|Rhodocyclales KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_966473_1 29581.BW37_03174 4.76e-33 126.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,472AX@75682|Oxalobacteraceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_966473_2 1500894.JQNN01000001_gene4022 9.84e-09 57.4 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,472I3@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_253504_1 1123277.KB893217_gene4668 4.2e-69 234.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,47K8Q@768503|Cytophagia 976|Bacteroidetes E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_325792_1 1000565.METUNv1_03597 1.81e-139 423.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2VK5U@28216|Betaproteobacteria,2KYM2@206389|Rhodocyclales 206389|Rhodocyclales C Sarcosine oxidase, gamma subunit family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_145677_1 1279009.ADICEAN_02545 3.34e-07 58.9 COG2202@1|root,COG5000@1|root,COG2202@2|Bacteria,COG5000@2|Bacteria,4NFFM@976|Bacteroidetes 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_717521_1 1198452.Jab_2c26410 2.17e-75 255.0 COG0642@1|root,COG4191@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1 k59_110084_1 1000565.METUNv1_02732 1.91e-193 543.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales 206389|Rhodocyclales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16 k59_432824_1 640081.Dsui_0698 2.62e-67 213.0 28P5Y@1|root,2ZC0T@2|Bacteria,1RBDV@1224|Proteobacteria,2VZTY@28216|Betaproteobacteria,2KYJ2@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_966485_1 292.DM42_2055 1.52e-18 85.1 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,2WGG1@28216|Betaproteobacteria,1K2RM@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_966485_2 1218075.BAYA01000082_gene7154 2.93e-39 145.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,2WGG1@28216|Betaproteobacteria,1K2RM@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_325801_2 1000565.METUNv1_00561 7.26e-206 577.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,2KUEZ@206389|Rhodocyclales 206389|Rhodocyclales E Cysteine desulfurase - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_325801_3 1000565.METUNv1_00562 8.81e-37 133.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,2KUBJ@206389|Rhodocyclales 206389|Rhodocyclales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_647199_1 1485544.JQKP01000003_gene191 7.77e-28 113.0 COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2VH62@28216|Betaproteobacteria,44VAQ@713636|Nitrosomonadales 28216|Betaproteobacteria T Integral membrane sensor signal transduction histidine kinase kdpD - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,GAF_3,HATPase_c,HisKA,KdpD k59_647199_2 748247.AZKH_1661 8.01e-95 284.0 COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,2KUZU@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulatory protein, C terminal - - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_647199_3 1538295.JY96_17575 1.5e-86 275.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KJ7D@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_1109313_1 529818.AMSG_12225T0 1.42e-43 160.0 COG1034@1|root,KOG3675@1|root,KOG2282@2759|Eukaryota,KOG3675@2759|Eukaryota 2759|Eukaryota O dipeptidyl-peptidase activity NDUFS1 GO:0003674,GO:0003824,GO:0003954,GO:0004177,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0005758,GO:0005759,GO:0005829,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006508,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008238,GO:0008239,GO:0008270,GO:0008637,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009507,GO:0009536,GO:0009853,GO:0009987,GO:0010257,GO:0012501,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016604,GO:0016607,GO:0016651,GO:0016655,GO:0016787,GO:0017144,GO:0019538,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042391,GO:0042773,GO:0042775,GO:0043094,GO:0043167,GO:0043169,GO:0043170,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050136,GO:0050896,GO:0051536,GO:0051540,GO:0051881,GO:0055086,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0070011,GO:0070013,GO:0070469,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072593,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0140096,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3,3.4.14.4 ko:K01277,ko:K03934 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko01002 3.D.1.6 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C,Peptidase_M49 k59_1109313_3 7668.SPU_013052-tr 1.11e-21 88.6 COG0636@1|root,KOG3025@2759|Eukaryota,3A3YG@33154|Opisthokonta,3BS02@33208|Metazoa,3D841@33213|Bilateria 33208|Metazoa C ATP synthesis coupled proton transport - GO:0000276,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02128 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - - ATP-synt_C k59_930586_1 1000565.METUNv1_01323 3.74e-286 791.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 transport system, permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_930586_2 1000565.METUNv1_01324 9.26e-200 560.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,2KVQ7@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_930586_3 1000565.METUNv1_01325 2.45e-100 295.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,2KV37@206389|Rhodocyclales 206389|Rhodocyclales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_289319_1 983917.RGE_28350 1.04e-24 104.0 COG0582@1|root,COG0582@2|Bacteria,1MXE7@1224|Proteobacteria,2W0S2@28216|Betaproteobacteria 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_1038782_1 1000565.METUNv1_00833 2.63e-17 79.3 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,2KU7P@206389|Rhodocyclales 206389|Rhodocyclales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1038782_2 1000565.METUNv1_00832 2.66e-283 774.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,2KV1Z@206389|Rhodocyclales 206389|Rhodocyclales J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_1038782_3 1000565.METUNv1_00831 2.29e-113 330.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2VHAM@28216|Betaproteobacteria,2KVFM@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_360644_1 1121098.HMPREF1534_00989 4.01e-07 53.1 COG4123@1|root,COG4123@2|Bacteria,4NG1X@976|Bacteroidetes,2FMHH@200643|Bacteroidia,4AN81@815|Bacteroidaceae 976|Bacteroidetes J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) smtA GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016430,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS k59_360644_2 509635.N824_04255 4.04e-57 182.0 COG0262@1|root,COG0262@2|Bacteria,4NQ2Y@976|Bacteroidetes,1ISG3@117747|Sphingobacteriia 976|Bacteroidetes H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - 2TM,DHFR_1 k59_1109323_1 517417.Cpar_1427 1.08e-25 102.0 COG0590@1|root,COG0590@2|Bacteria,1FF8K@1090|Chlorobi 1090|Chlorobi FJ PFAM CMP dCMP deaminase zinc-binding - - - - - - - - - - - - dCMP_cyt_deam_1 k59_538182_1 1349767.GJA_3863 6.07e-136 417.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,475Z8@75682|Oxalobacteraceae 28216|Betaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_154585_1 640081.Dsui_2320 2.95e-58 193.0 28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,2KVDQ@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2863) - - - - - - - - - - - - DUF2863 k59_759495_1 640081.Dsui_1099 9.77e-142 413.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_725392_1 1538295.JY96_19830 4.79e-86 261.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,1KK8I@119065|unclassified Burkholderiales 28216|Betaproteobacteria D Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_725392_2 266264.Rmet_0522 8.87e-08 52.8 2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,2WGJ3@28216|Betaproteobacteria,1KIJE@119060|Burkholderiaceae 28216|Betaproteobacteria M Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_1046372_1 1046724.KB889886_gene499 1.62e-34 120.0 COG3905@1|root,COG3905@2|Bacteria,1N1H6@1224|Proteobacteria,1SCIN@1236|Gammaproteobacteria 1236|Gammaproteobacteria K .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - - - - - - - - - - - k59_404489_1 1268622.AVS7_04609 3.34e-105 311.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,4AAWK@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_759504_1 104355.XP_007871309.1 5.01e-16 71.2 2E1I0@1|root,2S8UZ@2759|Eukaryota,3A9DK@33154|Opisthokonta,3Q6KM@4751|Fungi,3V5DS@5204|Basidiomycota 4751|Fungi - - - - - - - - - - - - - - - k59_197330_1 375286.mma_2159 7.18e-52 169.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,4743C@75682|Oxalobacteraceae 28216|Betaproteobacteria S colicin V production cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_197330_2 1502852.FG94_03589 6.33e-12 64.3 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,473S9@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_476338_1 1244869.H261_05709 2.64e-134 391.0 COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2TSSQ@28211|Alphaproteobacteria,2JT5R@204441|Rhodospirillales 204441|Rhodospirillales T HWE histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_2,PAS,PAS_9 k59_83319_2 743836.AYNA01000045_gene1237 1.7e-30 112.0 COG5579@1|root,COG5579@2|Bacteria,1RGXV@1224|Proteobacteria,2U9EH@28211|Alphaproteobacteria,36YP9@31993|Methylocystaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1810) - - - - - - - - - - - - DUF1810 k59_904962_3 1211814.CAPG01000027_gene1326 6.18e-08 60.5 COG5301@1|root,COG5301@2|Bacteria,1VEZ9@1239|Firmicutes,4HNUH@91061|Bacilli 91061|Bacilli G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_339862_1 1000565.METUNv1_03140 9.15e-26 97.4 COG2944@1|root,COG2944@2|Bacteria,1NHAH@1224|Proteobacteria,2VXNT@28216|Betaproteobacteria,2KZCN@206389|Rhodocyclales 206389|Rhodocyclales K sequence-specific DNA binding - - - - - - - - - - - - - k59_339862_2 640081.Dsui_2840 1.51e-60 197.0 COG0535@1|root,COG0535@2|Bacteria,1ND1B@1224|Proteobacteria,2VJRZ@28216|Betaproteobacteria 28216|Betaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_262653_1 1198452.Jab_1c01810 1.54e-115 347.0 2DB7W@1|root,2Z7P1@2|Bacteria,1N65F@1224|Proteobacteria,2VK71@28216|Betaproteobacteria,476Q2@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4331) - - - - - - - - - - - - DUF4331 k59_447835_1 1121912.AUHD01000001_gene2875 1.49e-10 67.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1HXFM@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_546268_1 1157708.KB907451_gene4738 3.39e-36 133.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,2VI48@28216|Betaproteobacteria,4AD28@80864|Comamonadaceae 28216|Betaproteobacteria J PFAM Ion transport protein kch - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_339888_1 1100720.ALKN01000031_gene1318 6.04e-92 286.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,4AA3W@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_11722_1 614083.AWQR01000029_gene2184 2.07e-67 222.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,2WHEY@28216|Betaproteobacteria,4AJW2@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_973813_1 1000565.METUNv1_00835 7.98e-61 196.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,2KUDH@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_973813_2 1000565.METUNv1_00834 6.13e-45 149.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,2KW8D@206389|Rhodocyclales 206389|Rhodocyclales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_662210_1 999141.GME_12474 6.03e-47 160.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XH40@135619|Oceanospirillales 135619|Oceanospirillales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_662210_2 857571.EA1_08317 3.04e-33 119.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,3NN3B@468|Moraxellaceae 1236|Gammaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_83349_1 1218352.B597_004930 1.01e-20 91.7 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1Z1U9@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_83349_2 521719.ATXQ01000007_gene1178 4.01e-56 186.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1YDYY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1011911_1 397945.Aave_4416 1.25e-106 312.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,4AAKG@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_83351_1 1235813.JCM10003_3686 5.61e-09 61.6 2CIBF@1|root,2Z85N@2|Bacteria,4NF0J@976|Bacteroidetes,2FQ5H@200643|Bacteroidia,4ANSR@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_580715_2 1415779.JOMH01000001_gene805 3.59e-06 50.4 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_83357_1 614083.AWQR01000004_gene858 5.14e-78 241.0 COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2VM6S@28216|Betaproteobacteria,4AAUB@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr abmB GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 ko:K00019,ko:K07535 ko00072,ko00362,ko00650,ko01100,ko01120,ko01220,map00072,map00362,map00650,map01100,map01120,map01220 M00088,M00540 R01361,R05582 RC00117,RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_404533_1 228410.NE2538 1.29e-62 199.0 COG2856@1|root,COG2856@2|Bacteria,1RAU7@1224|Proteobacteria,2VHN8@28216|Betaproteobacteria 28216|Betaproteobacteria E IrrE N-terminal-like domain - - - - - - - - - - - - Peptidase_M78 k59_404533_2 228410.NE2539 7.88e-34 125.0 28IV0@1|root,2Z8TM@2|Bacteria,1QK38@1224|Proteobacteria,2VPBA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_759552_1 1123392.AQWL01000022_gene2182 2.17e-36 136.0 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,1KRZ7@119069|Hydrogenophilales 119069|Hydrogenophilales S DUF218 domain - - - - - - - - - - - - DUF218 k59_759552_2 1000565.METUNv1_01997 4.1e-61 192.0 2DTQA@1|root,33M9S@2|Bacteria,1NGQ0@1224|Proteobacteria,2VYYZ@28216|Betaproteobacteria,2KXH0@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2802) - - - - - - - - - - - - DUF2802 k59_262697_1 640081.Dsui_2854 3.46e-27 115.0 COG2831@1|root,COG2831@2|Bacteria,1MXF6@1224|Proteobacteria,2W98S@28216|Betaproteobacteria,2KWW2@206389|Rhodocyclales 206389|Rhodocyclales U POTRA domain - - - - - - - - - - - - POTRA_2,POTRA_3,ShlB k59_688489_1 876044.IMCC3088_801 3.93e-07 52.0 COG0346@1|root,COG0346@2|Bacteria,1MVIQ@1224|Proteobacteria,1RZ9P@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_688489_2 326424.FRAAL2325 0.000127 45.8 COG0654@1|root,COG0654@2|Bacteria,2GK88@201174|Actinobacteria 201174|Actinobacteria CH PFAM monooxygenase FAD-binding - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_370573_1 1000565.METUNv1_02379 5.13e-07 54.3 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VT7G@28216|Betaproteobacteria,2KWQS@206389|Rhodocyclales 206389|Rhodocyclales S Sel1 domain-containing protein repeat-containing protein - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_905008_1 9606.ENSP00000354982 1.21e-99 299.0 COG1845@1|root,KOG4664@2759|Eukaryota,39ASV@33154|Opisthokonta,3BF9J@33208|Metazoa,3CUZX@33213|Bilateria,488M1@7711|Chordata,499D3@7742|Vertebrata,3JFS4@40674|Mammalia,35M1J@314146|Euarchontoglires,4MQCD@9443|Primates,4MTZT@9604|Hominidae 33208|Metazoa C Subunits I, II and III form the functional core of the enzyme complex COX3 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0008150,GO:0008535,GO:0009987,GO:0016020,GO:0016043,GO:0017004,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045277,GO:0065003,GO:0070069,GO:0070469,GO:0071840,GO:0098796,GO:0098803 - ko:K02262 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX3 k59_905008_2 744985.HIMB59_00010080 4.53e-09 55.1 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,4BQ5B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_518711_1 69042.WH5701_14791 3.01e-29 108.0 COG0605@1|root,COG0605@2|Bacteria,1G0N2@1117|Cyanobacteria,1GZSS@1129|Synechococcus 1117|Cyanobacteria C radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_518711_2 1121374.KB891581_gene13 1.64e-16 82.8 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase regB - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_447909_1 543728.Vapar_5372 1.05e-119 347.0 COG4799@1|root,COG4799@2|Bacteria,1PDNC@1224|Proteobacteria,2VIGW@28216|Betaproteobacteria,4AC2U@80864|Comamonadaceae 28216|Betaproteobacteria I Carboxyl transferase domain mdcB - 4.1.1.87 ko:K13932 - - - - ko00000,ko01000 - - - Carboxyl_trans k59_798539_1 1538295.JY96_20790 7.35e-121 374.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KJJS@119065|unclassified Burkholderiales 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_1011935_1 522306.CAP2UW1_0670 3.64e-126 382.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,1KQ70@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_546312_1 365044.Pnap_0708 8.78e-132 379.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,4A9MH@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1088771_1 614083.AWQR01000014_gene2471 1.63e-145 427.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,4ABI0@80864|Comamonadaceae 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1116682_1 497964.CfE428DRAFT_1743 6.53e-11 62.0 COG1166@1|root,COG1166@2|Bacteria,46S4T@74201|Verrucomicrobia 74201|Verrucomicrobia E arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_262711_1 1000565.METUNv1_01488 8.19e-96 311.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,2KVQ5@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl k59_197449_2 748247.AZKH_0427 8.26e-111 329.0 COG0697@1|root,COG0697@2|Bacteria,1R81I@1224|Proteobacteria,2VPRH@28216|Betaproteobacteria,2KUTJ@206389|Rhodocyclales 206389|Rhodocyclales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_725498_1 933115.GPDM_01180 8.56e-06 54.3 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,26CYX@186818|Planococcaceae 91061|Bacilli T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - DUF4084,EAL,GGDEF,PAS,PAS_9 k59_580744_1 1100721.ALKO01000036_gene2732 1.41e-69 221.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,4ABMU@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_48147_1 1000565.METUNv1_00135 1.04e-82 251.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,2KW1D@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_223078_1 1000565.METUNv1_03671 1.66e-146 481.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_518740_1 296591.Bpro_2172 1.49e-50 176.0 28M2S@1|root,2ZAH5@2|Bacteria,1MVH5@1224|Proteobacteria,2VM5E@28216|Betaproteobacteria,4AH42@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_520724_1 296591.Bpro_0748 7.88e-64 204.0 292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,2VRDD@28216|Betaproteobacteria,4AENK@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_341980_1 57918.XP_004296329.1 0.000179 50.4 COG2801@1|root,KOG1916@1|root,KOG0017@2759|Eukaryota,KOG1916@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids 35493|Streptophyta H transposition, RNA-mediated - - - - - - - - - - - - RVP_2,RVT_1,Retrotrans_gag,rve k59_13003_1 614083.AWQR01000044_gene2035 6.54e-104 320.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4AAAN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_760626_1 1198452.Jab_2c26200 9.54e-106 317.0 COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_799825_1 296591.Bpro_4614 2.92e-07 51.6 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,4AAGS@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_799825_2 365044.Pnap_3795 2.74e-48 162.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2VHH3@28216|Betaproteobacteria,4AAVW@80864|Comamonadaceae 28216|Betaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_689759_1 1198452.Jab_2c08390 2.16e-28 112.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472Z0@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter ybiT - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_689759_2 1095769.CAHF01000011_gene2201 3.7e-33 122.0 2E56W@1|root,32ZZK@2|Bacteria,1NET3@1224|Proteobacteria,2VXEX@28216|Betaproteobacteria,477G3@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_689760_2 29581.BW37_01317 5.41e-78 232.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,474AD@75682|Oxalobacteraceae 28216|Betaproteobacteria C Required for insertion of 4Fe-4S clusters erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_1048512_1 1538295.JY96_00255 1.08e-43 148.0 COG0431@1|root,COG0431@2|Bacteria,1MVEB@1224|Proteobacteria,2VHIX@28216|Betaproteobacteria,1KK65@119065|unclassified Burkholderiales 28216|Betaproteobacteria S NADPH-dependent FMN reductase - - - ko:K11811 - - - - ko00000 - - - FMN_red k59_1048512_2 596153.Alide_2695 2.97e-234 677.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1089660_1 398767.Glov_0298 9.46e-86 265.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42NPS@68525|delta/epsilon subdivisions,2WTSV@28221|Deltaproteobacteria 28221|Deltaproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_939059_1 869209.Tresu_1011 5.04e-67 215.0 COG0399@1|root,COG0399@2|Bacteria,2J6F4@203691|Spirochaetes 203691|Spirochaetes E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.33,2.6.1.98 ko:K13017,ko:K20429 ko00520,map00520 - R02773,R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_1048542_1 1267211.KI669560_gene1949 1.79e-127 367.0 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IPIY@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase pabB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_975140_1 543728.Vapar_3229 1.21e-20 87.4 COG2944@1|root,COG2944@2|Bacteria,1N21E@1224|Proteobacteria,2VUAS@28216|Betaproteobacteria,4AF56@80864|Comamonadaceae 28216|Betaproteobacteria K Helix-turn-helix domain protein - - - - - - - - - - - - HTH_3,HTH_31 k59_975140_2 296591.Bpro_4891 1.01e-54 181.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,4AB1H@80864|Comamonadaceae 28216|Betaproteobacteria P ammonium transporter - - - ko:K03320,ko:K06580 - - - - ko00000,ko02000,ko04090 1.A.11,1.A.11.4 - - Ammonium_transp k59_199470_1 1390370.O203_14560 4.01e-58 197.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YDZ6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_1117831_1 1000565.METUNv1_01405 3.86e-68 207.0 COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2VRX8@28216|Betaproteobacteria,2KYU2@206389|Rhodocyclales 206389|Rhodocyclales H Pterin 4 alpha carbinolamine dehydratase - - - - - - - - - - - - Pterin_4a k59_1117831_2 1000565.METUNv1_01406 2.51e-62 202.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,2KUC4@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_119740_1 1122605.KB893629_gene4130 5.75e-78 258.0 COG3536@1|root,COG3536@2|Bacteria,4PKQ9@976|Bacteroidetes,1IRMG@117747|Sphingobacteriia 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - - k59_405522_1 1121459.AQXE01000013_gene2265 0.00039 48.5 COG0834@1|root,COG0834@2|Bacteria,1PDU4@1224|Proteobacteria,43EHB@68525|delta/epsilon subdivisions,2X0PE@28221|Deltaproteobacteria,2MD07@213115|Desulfovibrionales 28221|Deltaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_156044_1 1349767.GJA_2364 1.3e-75 239.0 COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2VN9A@28216|Betaproteobacteria,47680@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2252) - - - - - - - - - - - - DUF2252 k59_386145_1 1198452.Jab_1c07630 4.92e-73 241.0 COG0845@1|root,COG0845@2|Bacteria,1P5GT@1224|Proteobacteria 1224|Proteobacteria M COG1566 Multidrug resistance efflux pump - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_96289_1 1000565.METUNv1_00550 4.76e-101 319.0 COG4733@1|root,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,2VQCZ@28216|Betaproteobacteria 28216|Betaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_1025087_1 66373.JOFQ01000032_gene4012 9.54e-58 185.0 COG5113@1|root,COG3236@2|Bacteria,2HQRT@201174|Actinobacteria 201174|Actinobacteria O protein conserved in bacteria - - - ko:K09935 - - - - ko00000 - - - DUF1768 k59_1025087_2 1123508.JH636443_gene4983 4.24e-37 132.0 2C03A@1|root,2Z86B@2|Bacteria,2IXDZ@203682|Planctomycetes 203682|Planctomycetes S Domain of unknown function (DUF4291) - - - - - - - - - - - - DUF4291 k59_701191_1 925409.KI911562_gene1477 1.94e-90 291.0 COG0178@1|root,COG0178@2|Bacteria,4NEHM@976|Bacteroidetes,1IQY4@117747|Sphingobacteriia 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - AAA_21,ABC_tran k59_1025088_1 1000565.METUNv1_01558 1.03e-107 327.0 COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,2VNRY@28216|Betaproteobacteria,2KXBD@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262 k59_167504_1 981335.G4W952_9CAUD 2.68e-10 65.5 4QFZI@10239|Viruses,4QX8G@35237|dsDNA viruses no RNA stage,4QPD8@28883|Caudovirales 28883|Caudovirales S Terminase-like family - - - - - - - - - - - - - k59_131524_1 161528.ED21_25297 6.17e-61 200.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TU94@28211|Alphaproteobacteria,2K2VX@204457|Sphingomonadales 204457|Sphingomonadales I COG0332 3-oxoacyl- acyl-carrier-protein synthase III - - 2.3.1.207 ko:K16872 - - - - ko00000,ko01000 - - - ACP_syn_III,ACP_syn_III_C k59_810948_1 1123368.AUIS01000009_gene2432 3.54e-43 155.0 COG2124@1|root,COG2124@2|Bacteria,1MWI3@1224|Proteobacteria,1RRRG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Fatty acid alpha hydroxylase - - 1.11.2.4 ko:K15629 - - R09740 - ko00000,ko00199,ko01000 - - - p450 k59_167509_2 240016.ABIZ01000001_gene2205 2.45e-15 73.2 COG0745@1|root,COG0745@2|Bacteria,46TYS@74201|Verrucomicrobia,2IV90@203494|Verrucomicrobiae 203494|Verrucomicrobiae T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_24308_1 688245.CtCNB1_3499 3.45e-35 133.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VRIK@28216|Betaproteobacteria,4ABP5@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase internal region - - - - - - - - - - - - HATPase_c,His_kinase k59_986557_1 395495.Lcho_4232 1.57e-07 52.4 2E6BG@1|root,330Z9@2|Bacteria,1N126@1224|Proteobacteria,2VW8F@28216|Betaproteobacteria,1KP8X@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_276277_1 743722.Sph21_3158 1.29e-82 260.0 COG0069@1|root,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,1IREF@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the glutamate synthase family glt - - - - - - - - - - - Glu_synthase k59_415663_1 1443125.Z962_07235 7.5e-06 46.6 COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,36MSK@31979|Clostridiaceae 186801|Clostridia J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_415663_2 1449058.JQKT01000009_gene43 2.72e-22 90.9 COG0186@1|root,COG0186@2|Bacteria,2IQ68@201174|Actinobacteria,4FP9J@85023|Microbacteriaceae 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_233883_1 596154.Alide2_2070 5.55e-123 365.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2VI7W@28216|Betaproteobacteria,4ACXW@80864|Comamonadaceae 28216|Betaproteobacteria L Recombinase - - - ko:K06400 - - - - ko00000 - - - HTH_7,Recombinase,Resolvase,Zn_ribbon_recom k59_386272_1 452637.Oter_2288 7.01e-51 166.0 COG0629@1|root,COG0629@2|Bacteria,46VZR@74201|Verrucomicrobia,3K80H@414999|Opitutae 414999|Opitutae L Single-stranded DNA-binding protein - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_315149_1 755732.Fluta_0493 2.16e-38 140.0 28IM1@1|root,2Z8MK@2|Bacteria,4NIZ0@976|Bacteroidetes,1HYU0@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_624819_1 1127692.HMPREF9075_01768 3.01e-73 240.0 COG3410@1|root,COG3410@2|Bacteria,4NGT9@976|Bacteroidetes,1I113@117743|Flavobacteriia 976|Bacteroidetes S Uncharacterized conserved protein (DUF2075) - - - - - - - - - - - - DUF2075 k59_770411_1 159087.Daro_0979 4.87e-85 270.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales 206389|Rhodocyclales C Respiratory-chain NADH dehydrogenase hoxF - 1.12.1.2 ko:K18005 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_276312_1 1237149.C900_04285 4.74e-61 208.0 COG0507@1|root,COG0507@2|Bacteria,4NF6J@976|Bacteroidetes,47JK1@768503|Cytophagia 976|Bacteroidetes L PIF1-like helicase - - - - - - - - - - - - HTH_40,Herpes_Helicase,PIF1 k59_131649_1 1223521.BBJX01000008_gene1329 9.87e-30 117.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,4A9NS@80864|Comamonadaceae 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_131649_2 1276756.AUEX01000009_gene1762 1.22e-30 116.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,4AAKA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1025239_1 883126.HMPREF9710_01297 8.21e-76 235.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,473G7@75682|Oxalobacteraceae 28216|Betaproteobacteria S alpha/beta hydrolase fold - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_1025239_2 1349767.GJA_521 7.25e-09 54.3 2CDFS@1|root,32RXQ@2|Bacteria,1N09V@1224|Proteobacteria,2VUR5@28216|Betaproteobacteria,4749A@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF2946) - - - - - - - - - - - - DUF2944 k59_1066550_1 1392838.AWNM01000006_gene2337 1.28e-08 57.4 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2VN3R@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1066550_2 1380391.JIAS01000011_gene5312 4.89e-27 107.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSIY@28211|Alphaproteobacteria,2JR5B@204441|Rhodospirillales 204441|Rhodospirillales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_591665_1 614083.AWQR01000018_gene1925 3.59e-100 307.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,4AAEG@80864|Comamonadaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family ilvG - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_986674_3 1198452.Jab_2c24900 1.39e-47 152.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,474U7@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_986674_4 1198452.Jab_2c24890 3.11e-38 133.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,472K9@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_233947_1 748247.AZKH_3172 1.29e-80 262.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KUV9@206389|Rhodocyclales 206389|Rhodocyclales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_948708_1 1300345.LF41_2410 3.77e-24 98.6 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria 1224|Proteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_948708_2 745310.G432_05070 1.93e-44 153.0 COG1974@1|root,COG1974@2|Bacteria,1N8IW@1224|Proteobacteria,2UIRW@28211|Alphaproteobacteria,2KA79@204457|Sphingomonadales 204457|Sphingomonadales K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_1025261_1 981223.AIED01000002_gene2038 4.35e-33 124.0 COG2207@1|root,COG2207@2|Bacteria,1NSQ2@1224|Proteobacteria,1SKQQ@1236|Gammaproteobacteria,3NKWU@468|Moraxellaceae 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_701352_2 188350.Q8H9S6_9CAUD 5.24e-07 53.9 4QGE6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_167648_1 883096.HMPREF9699_00561 1.32e-07 55.1 2A8ZB@1|root,30Y35@2|Bacteria,4NZ73@976|Bacteroidetes,1I6MF@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4279) - - - - - - - - - - - - DUF4279 k59_167648_2 543728.Vapar_5858 8.94e-40 141.0 2E8P4@1|root,3330A@2|Bacteria,1NFYA@1224|Proteobacteria,2W65T@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_591681_1 926559.JoomaDRAFT_3550 4.47e-92 276.0 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,1HXEE@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1025273_1 485918.Cpin_1615 1.21e-59 189.0 COG0087@1|root,COG0087@2|Bacteria,4NEAN@976|Bacteroidetes,1IPGZ@117747|Sphingobacteriia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_561276_1 1121033.AUCF01000008_gene5666 4.01e-17 80.5 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,2JPQ0@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_561276_2 1121033.AUCF01000001_gene2148 1.93e-50 166.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JQ1Y@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1066601_1 1454004.AW11_02533 2.7e-125 389.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1KPRS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_96488_1 909943.HIMB100_00022710 1.34e-63 202.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2TSR6@28211|Alphaproteobacteria,4BRF1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Pirin MA20_06040 - - ko:K06911 - - - - ko00000 - - - Pirin k59_1128773_1 640081.Dsui_2244 1.24e-27 111.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales 206389|Rhodocyclales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_948733_1 153948.NAL212_0410 1.71e-26 113.0 COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VMS2@28216|Betaproteobacteria,373ZZ@32003|Nitrosomonadales 28216|Betaproteobacteria S FecR protein - - - - - - - - - - - - FecR,LysM k59_96494_1 62928.azo0790 9.76e-132 378.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,2KVMT@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_96494_2 331869.BAL199_11536 8.92e-15 74.7 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria 28211|Alphaproteobacteria C carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_986729_1 83406.HDN1F_17610 2.08e-90 273.0 COG3687@1|root,COG3687@2|Bacteria,1MWGV@1224|Proteobacteria,1RZKP@1236|Gammaproteobacteria,1J7V5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_233995_1 1506583.JQJY01000008_gene3917 6.39e-106 321.0 COG2271@1|root,COG2271@2|Bacteria,4NE7R@976|Bacteroidetes,1I00T@117743|Flavobacteriia,2NTNU@237|Flavobacterium 976|Bacteroidetes G Major Facilitator exuT - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1 k59_701408_1 1198452.Jab_2c03190 5.05e-86 260.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2VKZJ@28216|Betaproteobacteria,472ZN@75682|Oxalobacteraceae 28216|Betaproteobacteria E phosphoserine phosphatase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - DUF4072,HAD k59_96538_1 944547.ABLL_2165 5.56e-22 96.7 2EUR9@1|root,33N6V@2|Bacteria,1P9CS@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_131752_1 1000565.METUNv1_03768 1.66e-127 385.0 COG0367@1|root,COG0367@2|Bacteria,1R769@1224|Proteobacteria,2W1JM@28216|Betaproteobacteria 28216|Betaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_916293_1 1122951.ATUE01000008_gene67 6.28e-89 286.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,3NJG7@468|Moraxellaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1069075_1 543728.Vapar_1410 1.1e-105 319.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,4A9TZ@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_949998_1 614083.AWQR01000013_gene1696 8.82e-120 350.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,4AAHK@80864|Comamonadaceae 28216|Betaproteobacteria C oxidoreductase FAD NAD(P)-binding domain protein ascD - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_98109_1 1000565.METUNv1_01238 2.14e-45 159.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,2KU7K@206389|Rhodocyclales 206389|Rhodocyclales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_771725_1 1122951.ATUE01000005_gene1859 1.53e-32 130.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis asmA - - ko:K07289 - - - - ko00000 - - - AsmA k59_592990_1 1166018.FAES_2001 2.32e-26 114.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,47K5T@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_25929_2 1279009.ADICEAN_03709 4.6e-17 79.3 2EK1J@1|root,33DS1@2|Bacteria,4NZB2@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_883937_1 1157708.KB907456_gene2493 8.9e-50 166.0 COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,2VRYZ@28216|Betaproteobacteria,4ADYE@80864|Comamonadaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_133251_1 596153.Alide_2563 1.05e-22 90.9 COG3171@1|root,COG3171@2|Bacteria,1N7Y4@1224|Proteobacteria,2VWZ0@28216|Betaproteobacteria,4AHSC@80864|Comamonadaceae 28216|Betaproteobacteria S Protein with unknown function (DUF469) - - - ko:K09923 - - - - ko00000 - - - DUF469 k59_133251_2 398578.Daci_4243 3.98e-44 148.0 2APJ5@1|root,31EN8@2|Bacteria,1RIPC@1224|Proteobacteria,2VT2M@28216|Betaproteobacteria,4AF9Q@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_812345_1 1198452.Jab_2c30180 1.7e-26 110.0 COG2186@1|root,COG2186@2|Bacteria,1QZYM@1224|Proteobacteria,2VI66@28216|Betaproteobacteria 28216|Betaproteobacteria K Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 k59_169287_1 1316936.K678_00185 8.82e-20 94.4 2DBPZ@1|root,2ZABJ@2|Bacteria,1R7CU@1224|Proteobacteria,2UEX4@28211|Alphaproteobacteria,2JW8R@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_717928_1 1000565.METUNv1_01017 3.07e-99 298.0 COG3284@1|root,COG3284@2|Bacteria,1R9CQ@1224|Proteobacteria 1224|Proteobacteria KQ Transcriptional regulator - - - - - - - - - - - - - k59_966881_1 1000565.METUNv1_02387 2.15e-104 313.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,2KV9Z@206389|Rhodocyclales 206389|Rhodocyclales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_966881_2 1000565.METUNv1_02386 1.3e-20 90.1 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUBK@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_505178_1 1198452.Jab_2c18160 2.6e-10 60.5 COG1653@1|root,COG1653@2|Bacteria,1MWHT@1224|Proteobacteria 1224|Proteobacteria G ABC-type sugar transport system periplasmic component - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 k59_505178_2 1198452.Jab_2c18120 8.19e-56 194.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria 1224|Proteobacteria P Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_789512_1 748247.AZKH_2453 2.46e-70 221.0 COG1024@1|root,COG1024@2|Bacteria,1R3SQ@1224|Proteobacteria,2VJRJ@28216|Betaproteobacteria,2KWFF@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl-CoA hydratase/isomerase - - 4.1.1.41 ko:K11264 ko00640,map00640 - R00923 RC00097 ko00000,ko00001,ko01000 - - - ECH_1 k59_1002994_1 614083.AWQR01000005_gene1138 5.37e-99 308.0 COG0128@1|root,COG0283@1|root,COG0128@2|Bacteria,COG0283@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,4AC71@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin,EPSP_synthase k59_966884_1 1000565.METUNv1_02655 6e-159 455.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,2KVD8@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_183787_2 1000565.METUNv1_00935 2.66e-140 416.0 COG0469@1|root,COG2046@1|root,COG0469@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria,2KYGT@206389|Rhodocyclales 206389|Rhodocyclales H PUA-like domain - - - - - - - - - - - - ATP-sulfurylase,PK,PUA_2 k59_930924_1 1437824.BN940_17346 7.54e-15 73.2 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,3T1NI@506|Alcaligenaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_930924_2 1000565.METUNv1_03374 3.51e-79 237.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,2KWEP@206389|Rhodocyclales 206389|Rhodocyclales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_930924_3 663610.JQKO01000008_gene78 4.79e-65 218.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,3NB2H@45404|Beijerinckiaceae 28211|Alphaproteobacteria C C-terminal domain of alpha-glycerophosphate oxidase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_361169_1 1000565.METUNv1_03799 1.06e-114 342.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,2KV10@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_361169_2 261292.Nit79A3_0350 5.96e-21 92.4 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,371KY@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_289966_1 1000565.METUNv1_00171 1.84e-99 306.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,2KV11@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_859822_1 1000565.METUNv1_02362 8.94e-111 338.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales 206389|Rhodocyclales T Type IV pili methyl-accepting chemotaxis transducer N-term - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3,PilJ k59_433785_1 666681.M301_2663 1.94e-55 183.0 COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2VJB9@28216|Betaproteobacteria 28216|Betaproteobacteria P membrane protein, terc ygjT - - ko:K05794 - - - - ko00000 - - - TerC k59_433785_2 344747.PM8797T_11731 1.47e-35 128.0 COG0861@1|root,COG0861@2|Bacteria,2IYX8@203682|Planctomycetes 203682|Planctomycetes P COG0861 Membrane protein TerC possibly involved in tellurium - - - - - - - - - - - - TerC k59_824658_2 563192.HMPREF0179_00191 2.65e-08 57.4 COG4540@1|root,COG4540@2|Bacteria,1R3UH@1224|Proteobacteria 1224|Proteobacteria S Baseplate assembly protein - - - - - - - - - - - - - k59_254100_1 983917.RGE_32240 1.8e-133 408.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ2M@119065|unclassified Burkholderiales 28216|Betaproteobacteria U AcrB/AcrD/AcrF family acrB - - ko:K18138,ko:K18146,ko:K18902 ko01501,ko01503,map01501,map01503 M00647,M00649,M00698,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.40 - - ACR_tran k59_752841_1 864051.BurJ1DRAFT_4162 5.08e-14 72.8 COG2010@1|root,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria,1KNJH@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,DUF302 k59_289974_1 640081.Dsui_0704 2.55e-18 88.2 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KV3Q@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN1 - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_289974_2 323848.Nmul_A0085 4.93e-44 149.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,372DG@32003|Nitrosomonadales 28216|Betaproteobacteria S Branched-chain amino acid ATP-binding cassette transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_467983_1 1000565.METUNv1_03275 3.37e-146 416.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,2KVIX@206389|Rhodocyclales 206389|Rhodocyclales E branched-chain amino acid - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_467983_2 1000565.METUNv1_03276 6.89e-129 370.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,2KU8C@206389|Rhodocyclales 206389|Rhodocyclales E ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_824669_1 864051.BurJ1DRAFT_4165 2.15e-56 191.0 COG0760@1|root,COG0760@2|Bacteria,1RGNX@1224|Proteobacteria,2VRQU@28216|Betaproteobacteria,1KNFK@119065|unclassified Burkholderiales 28216|Betaproteobacteria M SurA N-terminal domain - - - - - - - - - - - - Rotamase_2,SurA_N_3 k59_433806_1 388051.AUFE01000010_gene2568 9.43e-25 99.8 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,1K0ZU@119060|Burkholderiaceae 28216|Betaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_433806_2 640081.Dsui_2459 1.67e-29 108.0 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,2VWEY@28216|Betaproteobacteria,2KXCZ@206389|Rhodocyclales 206389|Rhodocyclales NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 k59_966913_1 1198452.Jab_2c25320 2.47e-82 249.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,473EZ@75682|Oxalobacteraceae 28216|Betaproteobacteria O Thioredoxin dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA,Thioredoxin k59_433809_1 1000565.METUNv1_00416 4.42e-35 130.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2VI7R@28216|Betaproteobacteria,2KWH4@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_505259_1 75379.Tint_0090 6.59e-99 294.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,1KJAQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_752852_3 365046.Rta_33100 1.9e-38 132.0 COG3772@1|root,COG3772@2|Bacteria,1N0ZQ@1224|Proteobacteria,2VVDM@28216|Betaproteobacteria 28216|Betaproteobacteria S lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_648162_1 1000565.METUNv1_00405 2.25e-50 163.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,2KWMK@206389|Rhodocyclales 206389|Rhodocyclales H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_648162_2 1000565.METUNv1_00406 8.45e-53 170.0 COG2703@1|root,COG2703@2|Bacteria,1MZJ3@1224|Proteobacteria,2VUV8@28216|Betaproteobacteria,2KX53@206389|Rhodocyclales 206389|Rhodocyclales P Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_648162_3 1000565.METUNv1_00407 1.35e-89 264.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,2KWDY@206389|Rhodocyclales 206389|Rhodocyclales J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_648162_4 1000565.METUNv1_00408 2.58e-43 144.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,2KW7M@206389|Rhodocyclales 206389|Rhodocyclales I Oligoketide cyclase lipid transport protein - - - - - - - - - - - - Polyketide_cyc k59_1109743_1 1123367.C666_13595 4.95e-69 223.0 COG3350@1|root,COG3350@2|Bacteria,1MWWK@1224|Proteobacteria,2VH88@28216|Betaproteobacteria,2KUMX@206389|Rhodocyclales 206389|Rhodocyclales S YHS domain - - - ko:K16242 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002,ko01000 - - - Phenol_Hydrox,YHS k59_1109743_2 1121004.ATVC01000014_gene2019 9.75e-14 66.6 2DGRK@1|root,32U7S@2|Bacteria,1N22H@1224|Proteobacteria,2VSPD@28216|Betaproteobacteria 28216|Betaproteobacteria S phenol hydroxylase poxE - - ko:K16245 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002 - - - Phenol_monoox k59_1003065_1 296591.Bpro_1798 3.35e-78 238.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,4A9PW@80864|Comamonadaceae 28216|Betaproteobacteria G HaD-superfamily hydrolase, subfamily ia, variant 3 gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_146126_1 204536.SULAZ_0339 4.36e-96 295.0 COG0677@1|root,COG0677@2|Bacteria,2G4GH@200783|Aquificae 200783|Aquificae M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1076542_1 1297865.APJD01000017_gene4248 1.66e-17 87.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2TRJU@28211|Alphaproteobacteria,3JTHA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1003083_1 365044.Pnap_2700 1.57e-136 400.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,4ABQY@80864|Comamonadaceae 28216|Betaproteobacteria I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - - - - - - - - - - - CoA_trans k59_397164_1 1198452.Jab_1c03600 8.69e-68 225.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,473JH@75682|Oxalobacteraceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_897559_9 1000565.METUNv1_01209 7.15e-91 286.0 2D784@1|root,32TNH@2|Bacteria,1N098@1224|Proteobacteria,2VX0M@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_897559_10 1094184.KWO_0108105 4.19e-82 249.0 2EKAP@1|root,33E0Y@2|Bacteria,1NAAI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_897559_13 1458275.AZ34_10310 1.65e-25 100.0 2EIY9@1|root,33CPF@2|Bacteria,1NNY6@1224|Proteobacteria 1224|Proteobacteria - - VP1586 - - - - - - - - - - - HTH_3 k59_897559_19 381666.H16_B1313 4.05e-44 154.0 COG4678@1|root,COG4678@2|Bacteria,1N2BW@1224|Proteobacteria,2VVEP@28216|Betaproteobacteria,1KA0V@119060|Burkholderiaceae 28216|Betaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_1003922_1 1000565.METUNv1_00242 6.16e-140 400.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VJCQ@28216|Betaproteobacteria,2KUHW@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1003922_2 264198.Reut_A0535 3.92e-11 62.8 2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,2VSJ5@28216|Betaproteobacteria,1K83E@119060|Burkholderiaceae 28216|Betaproteobacteria S Glycine-zipper domain - - - - - - - - - - - - Gly-zipper_OmpA,Gly-zipper_YMGG k59_649496_2 1123255.JHYS01000014_gene532 2.57e-73 236.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AAGH@80864|Comamonadaceae 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH k59_609908_1 452637.Oter_1968 4.18e-81 272.0 COG1020@1|root,COG1020@2|Bacteria 2|Bacteria Q D-alanine [D-alanyl carrier protein] ligase activity - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding k59_1040277_1 1189620.AJXL01000006_gene2418 1.75e-51 178.0 COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,1HY25@117743|Flavobacteriia,2NSIM@237|Flavobacterium 976|Bacteroidetes E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_574833_1 76114.ebA3647 2.76e-37 137.0 COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,2KV3A@206389|Rhodocyclales 206389|Rhodocyclales S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_1077871_1 1000565.METUNv1_02772 5.73e-97 300.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales 206389|Rhodocyclales V COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_328014_2 398767.Glov_2991 2.37e-110 335.0 COG1106@1|root,COG1106@2|Bacteria,1MVU0@1224|Proteobacteria 1224|Proteobacteria S Abortive infection protein - - - ko:K06926 - - - - ko00000 - - - AAA_21 k59_1077876_1 1000565.METUNv1_00323 3.52e-35 128.0 COG1317@1|root,COG1317@2|Bacteria,1NMQE@1224|Proteobacteria,2WGCR@28216|Betaproteobacteria,2KZU2@206389|Rhodocyclales 206389|Rhodocyclales N COG1317 Flagellar biosynthesis type III secretory pathway protein - - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH k59_1077876_2 1000565.METUNv1_00324 5.26e-15 73.2 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2VI19@28216|Betaproteobacteria,2KUSM@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor switch protein fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_860479_1 981336.F944_00537 3.61e-09 62.8 2CB45@1|root,33SCE@2|Bacteria,1NCNP@1224|Proteobacteria,1SEMV@1236|Gammaproteobacteria,3NIYR@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_398134_1 1120977.JHUX01000003_gene1925 6.63e-93 283.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,3NJPA@468|Moraxellaceae 1236|Gammaproteobacteria L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_398145_1 1000565.METUNv1_00700 7.62e-184 515.0 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,2VRY8@28216|Betaproteobacteria 28216|Betaproteobacteria I Enoyl-CoA hydratase - - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_146742_1 1000565.METUNv1_02279 3.87e-98 287.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,2KW6K@206389|Rhodocyclales 206389|Rhodocyclales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_435239_1 203122.Sde_2708 4.99e-28 117.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,46433@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_609926_1 1276756.AUEX01000014_gene2877 1.23e-29 112.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,4ABM8@80864|Comamonadaceae 28216|Betaproteobacteria I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645,ko:K15355 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_609926_2 59538.XP_005965632.1 6.12e-66 209.0 COG0332@1|root,2QUK2@2759|Eukaryota,3AA4W@33154|Opisthokonta,3BUPE@33208|Metazoa,3DBFG@33213|Bilateria 33208|Metazoa I 3-oxoacyl- acyl-carrier-protein synthase - - - - - - - - - - - - ACP_syn_III,ACP_syn_III_C k59_682018_1 1517416.IDAT_07950 2.87e-15 76.6 COG2980@1|root,COG2980@2|Bacteria,1N0JN@1224|Proteobacteria,1SAG4@1236|Gammaproteobacteria,2QGBV@267893|Idiomarinaceae 1236|Gammaproteobacteria M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788 LptE k59_1110350_2 1000565.METUNv1_02445 2.96e-123 382.0 COG3170@1|root,COG3170@2|Bacteria,1RE27@1224|Proteobacteria,2VRNH@28216|Betaproteobacteria,2KW0V@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_682019_1 1278309.KB907105_gene1507 4.79e-05 46.6 2DN81@1|root,32W0Z@2|Bacteria,1MZF2@1224|Proteobacteria,1S9F7@1236|Gammaproteobacteria,1XKU8@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_682019_2 1000565.METUNv1_02351 1.17e-114 332.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VR34@28216|Betaproteobacteria 28216|Betaproteobacteria P Reversible hydration of carbon dioxide cynT GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_40942_1 1000565.METUNv1_00480 1.48e-193 571.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_40942_2 522306.CAP2UW1_4273 0.0 917.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria 28216|Betaproteobacteria T prkA serine kinase prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_753466_1 1313301.AUGC01000006_gene128 1.75e-41 152.0 COG2176@1|root,COG2176@2|Bacteria,4PM8C@976|Bacteroidetes 976|Bacteroidetes L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_81674_1 1000565.METUNv1_00606 5.41e-85 254.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,2KWGB@206389|Rhodocyclales 206389|Rhodocyclales T Belongs to the low molecular weight phosphotyrosine protein phosphatase family ptpA - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_152542_1 397287.C807_03896 1.69e-36 141.0 COG1373@1|root,COG1373@2|Bacteria 2|Bacteria V ATPase (AAA superfamily - - - ko:K07133 - - - - ko00000 - - - HTH_36 k59_613661_1 640081.Dsui_2887 1.8e-42 140.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,2KWK7@206389|Rhodocyclales 206389|Rhodocyclales S YCII-related domain - - - ko:K09780 - - - - ko00000 - - - YCII k59_613661_2 1000565.METUNv1_00860 4.68e-26 102.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,2KVFB@206389|Rhodocyclales 206389|Rhodocyclales D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_337063_1 697282.Mettu_2503 1.82e-145 432.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1RPS2@1236|Gammaproteobacteria,1XE9M@135618|Methylococcales 135618|Methylococcales L PFAM Restriction endonuclease, type I, S subunit, EcoBI - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_337063_2 767434.Fraau_1097 8.97e-15 72.4 2CDR7@1|root,32TTG@2|Bacteria,1N18S@1224|Proteobacteria,1SC8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_544397_1 215158.Q858G5_BPE15 2.08e-08 54.7 4QH1B@10239|Viruses,4QXS0@35237|dsDNA viruses no RNA stage,4QS4T@28883|Caudovirales,4QP1Y@10744|Podoviridae 10744|Podoviridae S viral capsid, decoration - - - - - - - - - - - - - k59_544397_2 1003200.AXXA_28000 7.35e-13 65.5 2BWQK@1|root,336Z4@2|Bacteria,1NFES@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_152565_1 358220.C380_06710 1.4e-49 180.0 COG4585@1|root,COG4585@2|Bacteria,1R8DN@1224|Proteobacteria,2VPJ9@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_46398_1 614083.AWQR01000023_gene131 7.31e-120 349.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2VI0A@28216|Betaproteobacteria,4ABP7@80864|Comamonadaceae 28216|Betaproteobacteria N flagellar motor switch protein fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_262073_1 1235815.BAIX01000004_gene554 8.24e-09 55.8 COG2910@1|root,COG2910@2|Bacteria,4NI1N@976|Bacteroidetes,2FM0B@200643|Bacteroidia 976|Bacteroidetes S NmrA-like family - - - ko:K07118 - - - - ko00000 - - - NAD_binding_10 k59_262073_2 614083.AWQR01000030_gene2834 5.29e-77 238.0 COG0583@1|root,COG0583@2|Bacteria,1PJYV@1224|Proteobacteria,2VKXY@28216|Betaproteobacteria,4ADAP@80864|Comamonadaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_614524_1 1316936.K678_05518 6.11e-12 71.2 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2JYUM@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_7 k59_724921_1 1000565.METUNv1_01659 1.38e-39 144.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,2KZRQ@206389|Rhodocyclales 206389|Rhodocyclales H Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_724921_2 59538.XP_005976939.1 1.91e-40 154.0 COG0477@1|root,KOG3574@2759|Eukaryota 2759|Eukaryota EGP acetyl-CoA transmembrane transporter activity - - - ko:K03372 ko00604,ko01100,map00604,map01100 - - - ko00000,ko00001,ko01000,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_724921_3 1000565.METUNv1_01661 2.03e-33 122.0 COG1161@1|root,COG1161@2|Bacteria,1MV5H@1224|Proteobacteria,2VHAG@28216|Betaproteobacteria,2KVMC@206389|Rhodocyclales 206389|Rhodocyclales S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity - - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_1011434_1 1100721.ALKO01000024_gene490 4.59e-100 318.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_797912_2 1144319.PMI16_00707 2.56e-43 150.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,4726N@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_1045987_1 1540257.JQMW01000009_gene3123 0.000434 50.4 COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,36ED8@31979|Clostridiaceae 186801|Clostridia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C k59_369884_1 748247.AZKH_3372 1.42e-25 95.9 COG5450@1|root,COG5450@2|Bacteria,1N76R@1224|Proteobacteria,2VWE3@28216|Betaproteobacteria 28216|Betaproteobacteria K Bacterial antitoxin of type II TA system, VapB - - - - - - - - - - - - VapB_antitoxin k59_369884_2 748247.AZKH_3373 4.78e-62 193.0 COG1487@1|root,COG1487@2|Bacteria,1PUQH@1224|Proteobacteria,2WAVZ@28216|Betaproteobacteria,2KZEV@206389|Rhodocyclales 206389|Rhodocyclales S ribonuclease activity - - - - - - - - - - - - - k59_661317_1 338969.Rfer_1748 6.68e-24 111.0 2EDRK@1|root,337M5@2|Bacteria,1ND6H@1224|Proteobacteria,2VV2J@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_661317_2 1000565.METUNv1_01642 9.7e-120 348.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2VS5T@28216|Betaproteobacteria,2KW98@206389|Rhodocyclales 206389|Rhodocyclales D sister chromatid segregation - - - - - - - - - - - - - k59_973320_1 1118235.CAJH01000060_gene3371 7.57e-07 59.7 COG3637@1|root,COG4625@1|root,COG5184@1|root,COG3637@2|Bacteria,COG4625@2|Bacteria,COG5184@2|Bacteria,1QU2X@1224|Proteobacteria,1T77T@1236|Gammaproteobacteria,1X8X5@135614|Xanthomonadales 135614|Xanthomonadales M outer membrane autotransporter barrel domain - - - - - - - - - - - - Autotransporter,fn3 k59_797931_1 1000565.METUNv1_00993 6.86e-30 126.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_904577_1 765912.Thimo_3216 1.94e-112 332.0 COG1848@1|root,COG1848@2|Bacteria,1RJAI@1224|Proteobacteria,1SHAI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - - k59_904577_3 305900.GV64_15835 9.76e-19 88.2 2CCHT@1|root,2ZIZ5@2|Bacteria,1P7A1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_517848_1 1232683.ADIMK_2673 1.98e-25 110.0 COG2199@1|root,COG2203@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG4936@2|Bacteria,1R7HC@1224|Proteobacteria,1RYYR@1236|Gammaproteobacteria,46AFI@72275|Alteromonadaceae 1236|Gammaproteobacteria KT PAS PAC and GAF sensor-containing diguanylate cyclase - - - - - - - - - - - - CHASE,GAF_2,GGDEF,PAS_3,PAS_4,PAS_8,PocR k59_369908_1 1215092.PA6_007_01190 3.51e-08 55.8 COG5380@1|root,COG5380@2|Bacteria,1RF59@1224|Proteobacteria,1S5Q1@1236|Gammaproteobacteria,1YF70@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O May be involved in the folding of the extracellular lipase during its passage through the periplasm lifO GO:0006457,GO:0008150,GO:0009987 - - - - - - - - - - Lipase_chap k59_369908_2 930169.B5T_02391 2.68e-28 109.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1XJWG@135619|Oceanospirillales 135619|Oceanospirillales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_47607_2 755732.Fluta_0991 4.94e-25 100.0 COG3279@1|root,COG3279@2|Bacteria,4NK6R@976|Bacteroidetes,1HZ8M@117743|Flavobacteriia 976|Bacteroidetes T COG3279 Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_724968_1 1217718.ALOU01000002_gene4639 3.03e-160 483.0 COG0470@1|root,COG0470@2|Bacteria,1MVEE@1224|Proteobacteria,2VP7K@28216|Betaproteobacteria,1KBKF@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase III - - - - - - - - - - - - - k59_475830_1 522306.CAP2UW1_2148 1.83e-07 52.4 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,1KQ7Z@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_475830_2 1123508.JH636439_gene458 1.88e-40 149.0 COG3587@1|root,COG3587@2|Bacteria,2J2A2@203682|Planctomycetes 203682|Planctomycetes L Type III restriction enzyme, res subunit - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - ResIII k59_517861_1 1198452.Jab_2c17100 6.03e-112 331.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,473F3@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II/IV secretion system protein pilT2 - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_661362_1 640081.Dsui_0111 1.13e-80 253.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,2KVGH@206389|Rhodocyclales 206389|Rhodocyclales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_339077_1 1276756.AUEX01000013_gene1471 3.02e-130 392.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4AA18@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_404116_1 1000565.METUNv1_03545 1.26e-70 224.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,2KUR8@206389|Rhodocyclales 206389|Rhodocyclales T signal transduction protein containing EAL and modified HD-GYP domains - - - - - - - - - - - - HDOD k59_262150_1 1000565.METUNv1_01355 4.58e-187 532.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,2KVUQ@206389|Rhodocyclales 206389|Rhodocyclales C 24 kD subunit - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_797977_2 1249997.JHZW01000003_gene3560 2.77e-16 78.2 COG2070@1|root,COG2070@2|Bacteria,4NF8Z@976|Bacteroidetes,1HYHD@117743|Flavobacteriia,2PGRN@252356|Maribacter 976|Bacteroidetes S Nitronate monooxygenase fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_475856_1 675812.VHA_003150 1.41e-07 58.9 COG1670@1|root,COG3980@1|root,COG1670@2|Bacteria,COG3980@2|Bacteria,1Q330@1224|Proteobacteria,1RYTC@1236|Gammaproteobacteria,1XWJ6@135623|Vibrionales 135623|Vibrionales M Spore coat polysaccharide biosynthesis protein - - - - - - - - - - - - Acetyltransf_3 k59_11262_1 1000565.METUNv1_00203 1.45e-168 477.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,2KUQC@206389|Rhodocyclales 206389|Rhodocyclales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_222590_1 1123248.KB893314_gene3655 4.21e-116 348.0 COG0459@1|root,COG0459@2|Bacteria,4NDZM@976|Bacteroidetes,1INP2@117747|Sphingobacteriia 976|Bacteroidetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_47641_2 1000565.METUNv1_03059 7.44e-11 59.3 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,2KWJJ@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_797983_1 120017.I2FRK6 2.9e-13 75.9 COG1132@1|root,KOG0055@2759|Eukaryota,38E88@33154|Opisthokonta,3NU2T@4751|Fungi,3UZNI@5204|Basidiomycota,3N2AH@452284|Ustilaginomycotina 4751|Fungi Q ABC transporter transmembrane region - - 3.6.3.44 ko:K05658 ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226 - - - ko00000,ko00001,ko01000,ko02000,ko04090,ko04147 3.A.1.201 - - ABC_membrane,ABC_tran k59_1116188_1 1121887.AUDK01000008_gene1203 1.14e-14 80.1 COG0457@1|root,COG0457@2|Bacteria,4NMZG@976|Bacteroidetes,1ICYX@117743|Flavobacteriia,2NW87@237|Flavobacterium 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - DUF1736,PMT_2,TPR_16,TPR_2,TPR_8 k59_1046052_1 760117.JN27_00520 1.96e-67 226.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,472S7@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor yncD - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_298825_1 1349820.M707_02655 1.11e-31 112.0 2E5GW@1|root,3308F@2|Bacteria,2GX64@201174|Actinobacteria 201174|Actinobacteria S Protein of unknwon function (DUF3310) - - - - - - - - - - - - DUF3310 k59_1046056_2 1198452.Jab_2c18550 4.32e-40 142.0 COG0682@1|root,COG0682@2|Bacteria 2|Bacteria M lipoprotein biosynthetic process lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_369993_1 467661.RKLH11_2151 3.16e-52 181.0 COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,2TS75@28211|Alphaproteobacteria,3ZGGR@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria C thiol oxidoreductase - - - - - - - - - - - - DHOR k59_973386_1 1000565.METUNv1_00098 4.33e-08 53.1 COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VU37@28216|Betaproteobacteria,2KWYG@206389|Rhodocyclales 206389|Rhodocyclales S Lipopolysaccharide-assembly, LptC-related - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_973386_2 1000565.METUNv1_00097 2.21e-73 224.0 COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,2VSI4@28216|Betaproteobacteria,2KWMF@206389|Rhodocyclales 206389|Rhodocyclales S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_47670_1 629773.AORY01000005_gene2740 2.82e-116 338.0 COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2TRJ8@28211|Alphaproteobacteria,2K1AH@204457|Sphingomonadales 204457|Sphingomonadales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_867651_1 614083.AWQR01000029_gene2134 4.8e-97 286.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,4ABG3@80864|Comamonadaceae 28216|Betaproteobacteria D Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_1046065_1 1000565.METUNv1_01557 2.59e-89 290.0 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2VNYP@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 k59_475898_1 714943.Mucpa_6751 4.76e-30 116.0 COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,4PKSV@976|Bacteroidetes,1IP4K@117747|Sphingobacteriia 976|Bacteroidetes G BNR repeat-like domain - - - - - - - - - - - - BNR_2 k59_1088450_2 292415.Tbd_2069 6.71e-45 153.0 COG3355@1|root,COG3355@2|Bacteria,1N3ME@1224|Proteobacteria,2VTXQ@28216|Betaproteobacteria 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - - k59_688022_1 1150600.ADIARSV_0236 7.84e-77 239.0 COG3943@1|root,COG3943@2|Bacteria,4NEGN@976|Bacteroidetes,1IRCF@117747|Sphingobacteriia 976|Bacteroidetes S Virulence protein RhuM family - - - - - - - - - - - - Virulence_RhuM k59_614614_1 497964.CfE428DRAFT_4641 3.97e-49 186.0 COG3290@1|root,COG4251@1|root,COG3290@2|Bacteria,COG4251@2|Bacteria 2|Bacteria T photoreceptor activity exsG - 3.1.3.3 ko:K07315,ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01001,ko02022,ko03021 - - - GAF_2,GGDEF,HAMP,HATPase_c,HWE_HK,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SpoIIE,dCache_1 k59_580385_2 76114.ebA3297 3.63e-22 95.9 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VI73@28216|Betaproteobacteria,2KYGN@206389|Rhodocyclales 206389|Rhodocyclales C FAD binding domain - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_937669_1 614083.AWQR01000005_gene1061 5.52e-62 194.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,4AB23@80864|Comamonadaceae 28216|Betaproteobacteria S synthesis repressor, PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_1011534_1 296591.Bpro_1620 1.05e-123 362.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VK9Y@28216|Betaproteobacteria,4AA2K@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_904666_1 1000565.METUNv1_00325 2.31e-197 563.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2VI9M@28216|Betaproteobacteria,2KVMR@206389|Rhodocyclales 206389|Rhodocyclales N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_11326_2 1276756.AUEX01000020_gene3374 1.43e-50 166.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,4AB23@80864|Comamonadaceae 28216|Betaproteobacteria S synthesis repressor, PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_117921_1 748247.AZKH_3752 4.44e-18 81.6 COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,2KUNE@206389|Rhodocyclales 206389|Rhodocyclales G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_117921_2 1000565.METUNv1_03591 1.16e-68 220.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,2KURY@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1046093_1 395495.Lcho_2637 5.83e-28 110.0 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,1KK9B@119065|unclassified Burkholderiales 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1046093_2 1538295.JY96_19980 4.19e-36 125.0 COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,2VVQF@28216|Betaproteobacteria,1KMDQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE k59_518012_1 1121033.AUCF01000027_gene2753 1.74e-133 389.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,2JQFK@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the peptidase M16 family - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_196699_1 1123399.AQVE01000001_gene469 1.5e-81 253.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,461TK@72273|Thiotrichales 72273|Thiotrichales E Peptidase family M28 - - 3.5.3.9 ko:K02083 ko00230,ko01120,map00230,map01120 - R02423 RC00064 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1088475_1 204773.HEAR2989 1.36e-50 170.0 2DP0A@1|root,3300Q@2|Bacteria,1N78Y@1224|Proteobacteria,2VVZ5@28216|Betaproteobacteria,474AI@75682|Oxalobacteraceae 28216|Betaproteobacteria S PFAM Sporulation domain protein - - - - - - - - - - - - SPOR k59_485697_1 757424.Hsero_0816 1.53e-09 58.2 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,475XJ@75682|Oxalobacteraceae 28216|Betaproteobacteria NU PFAM Type II IV secretion system protein pilT - - ko:K02669,ko:K12203 - - - - ko00000,ko02035,ko02044 3.A.15.2,3.A.7.10.1,3.A.7.9.1 - - T2SSE k59_379434_1 1000565.METUNv1_01195 6.72e-116 365.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_271670_1 29581.BW37_04704 6.9e-16 75.1 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2VIU9@28216|Betaproteobacteria,472UJ@75682|Oxalobacteraceae 28216|Betaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_271670_2 29581.BW37_04705 2.03e-23 98.2 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,473JC@75682|Oxalobacteraceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_91499_1 194699.Q775D4_BPBPP 4.04e-199 621.0 4QHMX@10239|Viruses,4QW8C@35237|dsDNA viruses no RNA stage,4QRQS@28883|Caudovirales,4QNWI@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_806863_1 596154.Alide2_4290 2.55e-127 379.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,4ABKM@80864|Comamonadaceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_675563_1 523791.Kkor_0688 2.09e-69 223.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1XHZM@135619|Oceanospirillales 135619|Oceanospirillales M Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_696714_2 614083.AWQR01000009_gene714 2.35e-157 452.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae 28216|Betaproteobacteria S FAD dependent oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_56400_2 411684.HPDFL43_01560 2.67e-83 263.0 2CAIP@1|root,332XM@2|Bacteria,1N99C@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1094178_1 748247.AZKH_4103 1.09e-11 60.8 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,2VX71@28216|Betaproteobacteria 28216|Betaproteobacteria S May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_1094178_2 1218076.BAYB01000013_gene2826 9.62e-52 164.0 COG2440@1|root,COG2440@2|Bacteria,1RHTX@1224|Proteobacteria,2VSXZ@28216|Betaproteobacteria,1K8HQ@119060|Burkholderiaceae 28216|Betaproteobacteria C Could be a 3Fe-4S cluster-containing protein fixX - - ko:K03855 - - - - ko00000 - - - ETF_QO k59_1094178_3 1454004.AW11_01310 1.38e-05 46.2 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,1KPQS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S General function prediction only uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_411662_1 1492737.FEM08_22950 7.65e-20 88.2 COG2207@1|root,COG2207@2|Bacteria,4NHZ3@976|Bacteroidetes,1I32E@117743|Flavobacteriia,2NU81@237|Flavobacterium 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_18 k59_733274_1 614083.AWQR01000023_gene139 1.67e-18 79.7 COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,2VVQF@28216|Betaproteobacteria,4AF1J@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE k59_842243_1 1000565.METUNv1_02162 3.09e-69 227.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KVGM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_1124064_3 497321.C664_11007 1.47e-49 159.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,2KWNF@206389|Rhodocyclales 206389|Rhodocyclales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control ihfB - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1124064_4 1000565.METUNv1_02729 2.41e-29 115.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,2KUBW@206389|Rhodocyclales 206389|Rhodocyclales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_587656_2 397945.Aave_3287 1.25e-30 111.0 COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,4AEWA@80864|Comamonadaceae 28216|Betaproteobacteria S Lipopolysaccharide assembly protein A domain - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_1020219_1 1268622.AVS7_00428 8.16e-48 167.0 COG3297@1|root,COG3297@2|Bacteria,1MX9I@1224|Proteobacteria,2VH8V@28216|Betaproteobacteria,4AAUV@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM General secretion pathway L gspL - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_309491_1 443255.SCLAV_p0602 2.98e-55 189.0 COG2730@1|root,COG3386@1|root,COG2730@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Calx-beta,Cellulase,NHL,RicinB_lectin_2 k59_126954_2 1000565.METUNv1_01331 1.38e-179 514.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2VH2B@28216|Betaproteobacteria,2KVS2@206389|Rhodocyclales 206389|Rhodocyclales V extrusion protein MatE norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_485768_1 1157708.KB907457_gene2546 7.63e-94 293.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,4AABC@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefC - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_1094204_1 614083.AWQR01000018_gene1744 1.04e-105 320.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2VH7S@28216|Betaproteobacteria,4AB0E@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_353666_1 397945.Aave_3642 1.3e-30 113.0 COG3165@1|root,COG3165@2|Bacteria,1N314@1224|Proteobacteria,2VU2B@28216|Betaproteobacteria,4AEN6@80864|Comamonadaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_353666_2 1268622.AVS7_03027 4.75e-48 167.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,4A9ZQ@80864|Comamonadaceae 28216|Betaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_91558_2 1286631.X805_28020 1.94e-22 97.1 COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,2WFIY@28216|Betaproteobacteria 28216|Betaproteobacteria K Putative ATP-dependent DNA helicase recG C-terminal - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AlbA_2,HATPase_c_4 k59_230226_1 1000565.METUNv1_02238 1.53e-244 679.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,2KXUG@206389|Rhodocyclales 206389|Rhodocyclales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_1059789_1 1117318.PRUB_23101 5.69e-66 219.0 28JGG@1|root,2Z9A8@2|Bacteria,1R8WJ@1224|Proteobacteria,1RNV9@1236|Gammaproteobacteria,2Q436@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1020270_1 1430440.MGMSRv2_3644 6.13e-22 100.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_944864_1 536233.CLO_0721 2.72e-11 65.1 COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,248MW@186801|Clostridia,36F52@31979|Clostridiaceae 186801|Clostridia S Hydrolase - - - - - - - - - - - - Hydrolase_3 k59_944864_2 679937.Bcop_2455 4.31e-33 120.0 COG0692@1|root,COG0692@2|Bacteria,4NE2B@976|Bacteroidetes,2FM57@200643|Bacteroidia,4AMXR@815|Bacteroidaceae 976|Bacteroidetes L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_379597_1 795666.MW7_2950 6.5e-93 302.0 COG1002@1|root,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,2VPJC@28216|Betaproteobacteria,1K5G8@119060|Burkholderiaceae 28216|Betaproteobacteria V Pfam:Methyltransf_26 - - - - - - - - - - - - - k59_271794_1 1433126.BN938_1344 3.72e-50 175.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,2FP0Y@200643|Bacteroidia,22U7G@171550|Rikenellaceae 976|Bacteroidetes M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_353760_1 375286.mma_3292 1.19e-69 216.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,472AY@75682|Oxalobacteraceae 28216|Betaproteobacteria U Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_353760_2 1095769.CAHF01000003_gene1009 7.25e-14 71.6 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,472A9@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC-type multidrug transport system, ATPase component ybhF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_20205_1 700598.Niako_7078 3.4e-36 130.0 COG0811@1|root,COG0811@2|Bacteria,4NE8M@976|Bacteroidetes,1INP5@117747|Sphingobacteriia 976|Bacteroidetes U PFAM MotA TolQ ExbB proton channel exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_675747_1 1121897.AUGO01000018_gene1118 3.64e-26 105.0 COG3209@1|root,COG3209@2|Bacteria,4NE5D@976|Bacteroidetes,1HYTK@117743|Flavobacteriia,2NSHK@237|Flavobacterium 976|Bacteroidetes M RHS repeat-associated core domain - - - - - - - - - - - - - k59_842350_2 159087.Daro_3334 1.2e-66 213.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VJD8@28216|Betaproteobacteria,2KU6C@206389|Rhodocyclales 206389|Rhodocyclales E COG0436 Aspartate tyrosine aromatic aminotransferase - - 2.6.1.88 ko:K14287 - - R08618 RC00006,RC00025 ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_982205_1 1000565.METUNv1_00046 6.66e-103 333.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_806968_1 640081.Dsui_0500 6.09e-64 216.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_842352_1 402626.Rpic_3841 1.19e-16 78.2 COG3246@1|root,COG3246@2|Bacteria,1MXGN@1224|Proteobacteria,2VH01@28216|Betaproteobacteria,1KGV8@119060|Burkholderiaceae 28216|Betaproteobacteria S beta-keto acid cleavage enzyme - - - - - - - - - - - - BKACE k59_842352_2 1366050.N234_35020 1.41e-40 138.0 COG0599@1|root,COG0599@2|Bacteria,1N0Z6@1224|Proteobacteria,2W2N6@28216|Betaproteobacteria,1K5AV@119060|Burkholderiaceae 28216|Betaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_20210_1 1177928.TH2_15892 9.83e-81 258.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,2JPPI@204441|Rhodospirillales 204441|Rhodospirillales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_842354_1 1122179.KB890440_gene1011 9.9e-31 117.0 COG2197@1|root,COG2197@2|Bacteria,4NKAD@976|Bacteroidetes,1IT3A@117747|Sphingobacteriia 976|Bacteroidetes K Two component transcriptional regulator, LuxR family - - - - - - - - - - - - GerE,Response_reg k59_946146_1 700598.Niako_0102 2.86e-76 243.0 COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,1IPT9@117747|Sphingobacteriia 976|Bacteroidetes EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_211717_1 1396141.BATP01000056_gene3278 0.000487 48.1 COG0028@1|root,COG3055@1|root,COG3209@1|root,COG4625@1|root,COG4932@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,COG3209@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - 4.1.3.1 ko:K01637,ko:K20276 ko00630,ko01100,ko01110,ko01120,ko01200,ko02024,map00630,map01100,map01110,map01120,map01200,map02024 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - He_PIG,Laminin_G_3,Malectin k59_21653_1 105422.BBPM01000102_gene5262 2.13e-21 98.6 COG3055@1|root,COG3405@1|root,COG3055@2|Bacteria,COG3405@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - ASH k59_381985_1 509635.N824_18500 1.92e-50 179.0 COG0616@1|root,COG0616@2|Bacteria,4NES1@976|Bacteroidetes,1IP6H@117747|Sphingobacteriia 976|Bacteroidetes OU signal peptide peptidase SppA, 67K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_622482_2 1000565.METUNv1_03772 3.63e-145 416.0 COG1216@1|root,COG1216@2|Bacteria,1R1SJ@1224|Proteobacteria 1224|Proteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - - k59_808435_1 1000565.METUNv1_01567 1.17e-35 130.0 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,2KZTK@206389|Rhodocyclales 206389|Rhodocyclales K WYL domain - - - - - - - - - - - - WYL k59_1062215_1 1366050.N234_20685 6.42e-53 177.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VPNX@28216|Betaproteobacteria,1K091@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_164654_1 1123367.C666_16250 1.07e-116 345.0 2C4IG@1|root,2Z8A1@2|Bacteria,1QTHZ@1224|Proteobacteria,2VN98@28216|Betaproteobacteria,2KVXJ@206389|Rhodocyclales 206389|Rhodocyclales S Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - DUF1329 k59_211773_1 1122180.Lokhon_00092 7.44e-17 85.5 COG2755@1|root,COG2931@1|root,COG4932@1|root,COG2755@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - FecR,HCBP_related,HemolysinCabind k59_164664_1 535289.Dtpsy_1461 6.75e-158 477.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4AB5C@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07239,ko:K15726 - - - - ko00000,ko02000 2.A.6.1,2.A.6.1.2 - - ACR_tran k59_983608_1 296591.Bpro_2411 3.22e-125 365.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,4A9YH@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_356446_1 397945.Aave_2572 4.17e-125 365.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,4ABW5@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM isocitrate dehydrogenase, NADP-dependent icd GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_767953_2 1485544.JQKP01000011_gene745 3.26e-18 82.4 2E645@1|root,330T3@2|Bacteria,1NEGX@1224|Proteobacteria,2VY99@28216|Betaproteobacteria 28216|Betaproteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_487640_1 595537.Varpa_4712 5.31e-105 322.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,4ACYB@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family cyoB - 1.10.3.10 ko:K02298 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX1 k59_1125702_1 159087.Daro_0205 3.63e-45 155.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2VNH9@28216|Betaproteobacteria,2KU7D@206389|Rhodocyclales 206389|Rhodocyclales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1125702_2 266264.Rmet_0132 4.37e-11 62.8 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,1K1GG@119060|Burkholderiaceae 28216|Betaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_211796_1 1286631.X805_38870 1.59e-21 98.6 COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria,2WGS7@28216|Betaproteobacteria 28216|Betaproteobacteria M Outer membrane adhesin like proteiin - - - - - - - - - - - - Calx-beta,VWA_2 k59_808484_1 795666.MW7_3442 3.36e-25 110.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,1K1P9@119060|Burkholderiaceae 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_946210_1 998088.B565_1951 2.18e-37 138.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1Y4ZW@135624|Aeromonadales 135624|Aeromonadales C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_946210_2 999141.GME_00135 3.62e-39 135.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1XH6P@135619|Oceanospirillales 135619|Oceanospirillales C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_93300_1 1430440.MGMSRv2_4079 2.66e-16 78.6 COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VGKP@28211|Alphaproteobacteria,2JSTX@204441|Rhodospirillales 204441|Rhodospirillales S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_439668_1 1217718.ALOU01000007_gene1227 7.53e-56 196.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria 28216|Betaproteobacteria M surface antigen variable number repeat protein - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_471448_1 1000565.METUNv1_03058 1.28e-146 437.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales 206389|Rhodocyclales L DNA topoisomerase III - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k59_6870_1 1000565.METUNv1_01085 4.41e-148 422.0 COG0600@1|root,COG0600@2|Bacteria,1MV2D@1224|Proteobacteria,2VI6N@28216|Betaproteobacteria 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_257634_1 471854.Dfer_3218 2.62e-77 243.0 COG3356@1|root,COG3356@2|Bacteria,4NHGJ@976|Bacteroidetes,47N67@768503|Cytophagia 976|Bacteroidetes S PFAM Neutral alkaline nonlysosomal ceramidase - - - - - - - - - - - - - k59_471451_1 1000565.METUNv1_03166 1.23e-167 483.0 COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2WHI7@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_900558_1 543728.Vapar_4006 3.85e-46 156.0 COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2VSSM@28216|Betaproteobacteria 28216|Betaproteobacteria K AntiSigma factor - - - - - - - - - - - - zf-HC2 k59_439693_1 1000565.METUNv1_00871 7.4e-161 473.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,2KUS5@206389|Rhodocyclales 206389|Rhodocyclales C nitrite reductase NAD(P)H nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1007385_1 640511.BC1002_3123 1.75e-31 122.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K2NR@119060|Burkholderiaceae 28216|Betaproteobacteria E (GMC) oxidoreductase betA - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_400582_1 85643.Tmz1t_3249 3.8e-80 248.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VQAV@28216|Betaproteobacteria,2KWYB@206389|Rhodocyclales 206389|Rhodocyclales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_400582_2 105425.BBPL01000001_gene6320 6e-22 104.0 COG1215@1|root,COG1215@2|Bacteria,2I2NS@201174|Actinobacteria,2NF6Y@228398|Streptacidiphilus 201174|Actinobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_2 k59_400582_3 1235788.C802_01726 9.94e-06 52.0 COG0463@1|root,COG0463@2|Bacteria,4PKFU@976|Bacteroidetes 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_510907_1 1159870.KB907784_gene246 2.17e-122 361.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VKZU@28216|Betaproteobacteria,3T290@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_541548_4 379066.GAU_1797 2.26e-32 118.0 2CA0E@1|root,349DP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_684123_1 1121945.ATXS01000002_gene580 0.000256 47.8 arCOG02387@1|root,arCOG02387@2157|Archaea,2Y149@28890|Euryarchaeota,240V2@183963|Halobacteria 183963|Halobacteria T COG0784 FOG CheY-like receiver - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_43419_1 1121033.AUCF01000003_gene3277 2.15e-24 99.4 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,2JQG4@204441|Rhodospirillales 204441|Rhodospirillales CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family gyaR - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1007404_1 305700.B447_00545 3.03e-89 275.0 COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,2KUR4@206389|Rhodocyclales 206389|Rhodocyclales K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_611481_1 1121033.AUCF01000004_gene4648 6.72e-76 241.0 COG5338@1|root,COG5338@2|Bacteria,1PFWT@1224|Proteobacteria,2U090@28211|Alphaproteobacteria,2JQS1@204441|Rhodospirillales 204441|Rhodospirillales M Putative beta-barrel porin 2 - - - - - - - - - - - - BBP2_2 k59_541558_1 365046.Rta_24330 3.79e-72 219.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,4ADW4@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR exbD1 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_541558_2 1120999.JONM01000006_gene2313 2.91e-17 78.6 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,2KQZT@206351|Neisseriales 206351|Neisseriales U Transporter, MotA TolQ ExbB proton channel family protein - - - - - - - - - - - - MotA_ExbB k59_611488_1 338969.Rfer_3373 3.35e-87 264.0 COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,2VHQK@28216|Betaproteobacteria,4ACHW@80864|Comamonadaceae 28216|Betaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg k59_611488_2 596154.Alide2_3817 1.76e-18 84.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,4A9KA@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM Ribonuclease II rnb - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_1112336_1 1000565.METUNv1_03468 1.85e-65 201.0 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,2KVY3@206389|Rhodocyclales 206389|Rhodocyclales E Lactoylglutathione lyase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_1082469_1 85643.Tmz1t_2825 1.13e-44 160.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VMY1@28216|Betaproteobacteria,2KUWW@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_257683_1 614083.AWQR01000003_gene2918 3.08e-85 267.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,4ABKD@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_510961_1 1000565.METUNv1_03455 3.16e-12 65.1 COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,2VM0A@28216|Betaproteobacteria,2KXN6@206389|Rhodocyclales 206389|Rhodocyclales T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_510961_2 1000565.METUNv1_03456 1.28e-114 342.0 COG0515@1|root,COG0589@1|root,COG0515@2|Bacteria,COG0589@2|Bacteria,1MV1P@1224|Proteobacteria,2VM52@28216|Betaproteobacteria,2KYMH@206389|Rhodocyclales 206389|Rhodocyclales KLT Universal stress protein family - - - - - - - - - - - - Pkinase,Usp k59_113662_1 614083.AWQR01000005_gene1160 1.05e-68 217.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIXA@28216|Betaproteobacteria,4ABBP@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM polar amino acid ABC transporter, inner membrane subunit aapM - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_113662_2 614083.AWQR01000005_gene1161 2.93e-68 212.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,4ABJC@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related aapP - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_79128_1 1000565.METUNv1_03464 6.45e-131 382.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,2KVBK@206389|Rhodocyclales 206389|Rhodocyclales E The glycine cleavage system catalyzes the degradation of glycine - - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_900622_1 1000565.METUNv1_03462 1.7e-136 400.0 COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,2KXG7@206389|Rhodocyclales 206389|Rhodocyclales S Alkaline phosphatase - - - - - - - - - - - - - k59_364957_1 1123034.JMKP01000019_gene2552 9.93e-18 83.2 COG5342@1|root,COG5342@2|Bacteria,1Q5CR@1224|Proteobacteria,1S2DX@1236|Gammaproteobacteria,3NJP6@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1176) - - - - - - - - - - - - DUF1176 k59_364957_2 399795.CtesDRAFT_PD3984 2.53e-55 184.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,4A9SN@80864|Comamonadaceae 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_332318_1 925409.KI911562_gene415 6.4e-87 265.0 COG1560@1|root,COG1560@2|Bacteria,4NPAI@976|Bacteroidetes,1J0BY@117747|Sphingobacteriia 976|Bacteroidetes M Bacterial lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_332323_1 929562.Emtol_2227 5.81e-111 331.0 COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,47M9C@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_1112359_1 1000565.METUNv1_02726 7.05e-165 466.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2VIS1@28216|Betaproteobacteria,2KU90@206389|Rhodocyclales 206389|Rhodocyclales E Prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_685178_2 614083.AWQR01000011_gene2339 9.26e-13 67.4 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,4A9WS@80864|Comamonadaceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_721776_1 1000565.METUNv1_02428 2.19e-119 352.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,2KURU@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_512679_1 595537.Varpa_0641 2.66e-54 174.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,4AADG@80864|Comamonadaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_756403_1 1337936.IJ00_19815 2.48e-79 244.0 2E0I8@1|root,32W3Z@2|Bacteria,1GB6Y@1117|Cyanobacteria 1117|Cyanobacteria S Domain of unknown function (DUF4343) - - - - - - - - - - - - DUF4343 k59_901796_1 296591.Bpro_1980 1.01e-10 63.2 COG3307@1|root,COG3307@2|Bacteria,1R495@1224|Proteobacteria,2VKCN@28216|Betaproteobacteria,4AFXG@80864|Comamonadaceae 28216|Betaproteobacteria M O-Antigen ligase - - - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C k59_901796_2 946483.Cenrod_1621 1.11e-47 170.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4A9XP@80864|Comamonadaceae 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_191332_1 1286631.X805_40630 5.79e-106 318.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,1KJY5@119065|unclassified Burkholderiales 28216|Betaproteobacteria S benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_794262_2 864051.BurJ1DRAFT_1174 5.47e-93 283.0 2EMF3@1|root,2ZKNW@2|Bacteria,1RAZA@1224|Proteobacteria,2VQE2@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_934896_1 1000565.METUNv1_02896 5.9e-97 300.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUK3@206389|Rhodocyclales 206389|Rhodocyclales NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_934896_2 1000565.METUNv1_02895 2.37e-150 432.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,2KV1H@206389|Rhodocyclales 206389|Rhodocyclales P Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_612321_1 1116472.MGMO_11c00440 8.28e-97 294.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RRGA@1236|Gammaproteobacteria,1XEDF@135618|Methylococcales 135618|Methylococcales H Belongs to the alpha-IPM synthase homocitrate synthase family nifV - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_8009_1 1000565.METUNv1_03846 1.21e-105 315.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales 206389|Rhodocyclales H enzyme of heme biosynthesis hemY - - ko:K02498 - - - - ko00000 - - - HemY_N k59_1008546_1 1000565.METUNv1_01701 3.53e-10 59.3 2EN9I@1|root,33FXA@2|Bacteria,1NN3A@1224|Proteobacteria,2VXZF@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1008546_2 762376.AXYL_02054 1.14e-13 77.8 COG3756@1|root,COG3756@2|Bacteria,1RFD3@1224|Proteobacteria,2VWCR@28216|Betaproteobacteria,3T7Q3@506|Alcaligenaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_44525_2 1123367.C666_08905 1.91e-113 343.0 COG1196@1|root,COG1196@2|Bacteria,1R4R0@1224|Proteobacteria 1224|Proteobacteria D COG0419 ATPase involved in DNA repair - - - ko:K19171 - - - - ko00000,ko02048 - - - AAA_23 k59_441674_1 1144319.PMI16_03657 4.65e-101 308.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,472BC@75682|Oxalobacteraceae 28216|Betaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_441674_2 1454004.AW11_02708 3.97e-53 167.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,1KQ1S@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_612333_1 1179778.PMM47T1_15496 1.5e-41 153.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria 1224|Proteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_150403_1 1000565.METUNv1_02124 1.85e-225 630.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Sigma54_activat k59_150403_2 1000565.METUNv1_02123 2.52e-43 147.0 2DPJE@1|root,332CC@2|Bacteria,1PTZD@1224|Proteobacteria,2VWNZ@28216|Betaproteobacteria,2KX8U@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_150403_3 1000565.METUNv1_02122 2.23e-100 303.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,2KUT7@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase yfhK - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_191385_1 697282.Mettu_3421 1.04e-39 149.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XFKT@135618|Methylococcales 135618|Methylococcales T PFAM Chemotaxis methyl-accepting receptor, signalling - - - - - - - - - - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9,TarH k59_191385_2 1006004.GBAG_3342 1.07e-27 115.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Bac_globin,Cache_3-Cache_2,HAMP,MCPsignal,dCache_3 k59_1084351_1 1122951.ATUE01000008_gene203 8.39e-47 163.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,3NKC8@468|Moraxellaceae 1236|Gammaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_970645_1 358220.C380_20550 5.16e-84 265.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHAT@28216|Betaproteobacteria,4ABV3@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_685218_1 1198452.Jab_1c10100 1.73e-54 172.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,474CY@75682|Oxalobacteraceae 28216|Betaproteobacteria C [2Fe-2S] binding domain iorA - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_685218_2 1175306.GWL_36110 6.46e-11 61.2 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,472AK@75682|Oxalobacteraceae 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_114808_1 1122951.ATUE01000008_gene64 3.53e-61 199.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,3NKHJ@468|Moraxellaceae 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_685222_1 76114.ebA3370 8.23e-10 59.3 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KUAS@206389|Rhodocyclales 206389|Rhodocyclales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_685222_2 1123401.JHYQ01000009_gene2273 1.56e-12 67.8 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,463MH@72273|Thiotrichales 72273|Thiotrichales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_970649_1 557598.LHK_02296 4.68e-75 243.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,2KTXK@206351|Neisseriales 206351|Neisseriales P Sodium/hydrogen exchanger family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_1043591_1 981223.AIED01000009_gene3234 4.12e-144 436.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,3NJFY@468|Moraxellaceae 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164 PBP1_TM,Transgly,Transpeptidase,UB2H k59_441710_2 395965.Msil_3515 6.3e-19 79.3 2EMWV@1|root,33FJ4@2|Bacteria,1NI97@1224|Proteobacteria,2UJMC@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_401524_1 493475.GARC_4515 1.88e-24 102.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1S30T@1236|Gammaproteobacteria,4655K@72275|Alteromonadaceae 1236|Gammaproteobacteria T Histidine kinase response regulator - - - - - - - - - - - - GAF,HATPase_c,HisKA,Response_reg k59_401524_2 497964.CfE428DRAFT_1688 4.35e-33 132.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,46TV0@74201|Verrucomicrobia 74201|Verrucomicrobia T ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_901859_1 864051.BurJ1DRAFT_1032 2.17e-108 320.0 28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,2VJQS@28216|Betaproteobacteria,1KJA9@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Dinitrogenase reductase ADP-ribosyltransferase (DRAT) draT - 2.4.2.37 ko:K05951 - - - - ko00000,ko01000 - - - DRAT k59_512777_1 755732.Fluta_1225 8.08e-51 182.0 COG3023@1|root,COG3023@2|Bacteria,4NN1U@976|Bacteroidetes 976|Bacteroidetes V COGs COG3023 Negative regulator of beta-lactamase expression - - - - - - - - - - - - Amidase_2,CUB k59_1008580_1 1000565.METUNv1_03297 2.06e-63 218.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales 206389|Rhodocyclales KNT COG0643 Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_577922_1 614083.AWQR01000030_gene2720 1.32e-43 153.0 COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,4AAZP@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_612359_1 614083.AWQR01000008_gene496 1.76e-53 174.0 COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,2VN50@28216|Betaproteobacteria,4AEJ0@80864|Comamonadaceae 28216|Betaproteobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_794330_1 1122176.KB903538_gene1506 7.58e-36 135.0 COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,1IV9F@117747|Sphingobacteriia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2 k59_878373_1 1000565.METUNv1_02375 6.07e-79 249.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KU63@206389|Rhodocyclales 206389|Rhodocyclales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_1094970_1 1123277.KB893179_gene3130 0.000306 47.0 COG3827@1|root,COG3827@2|Bacteria,4PMMQ@976|Bacteroidetes,47Y53@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_128072_1 1198452.Jab_1c07880 3.29e-27 109.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,4732I@75682|Oxalobacteraceae 28216|Betaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_128072_2 29581.BW37_03143 1.52e-52 176.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,4737A@75682|Oxalobacteraceae 28216|Betaproteobacteria L A G-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_164262_1 1270193.JARP01000001_gene3346 9.43e-07 49.3 COG0177@1|root,COG0177@2|Bacteria,4NMJS@976|Bacteroidetes,1ICMU@117743|Flavobacteriia,2NTFS@237|Flavobacterium 976|Bacteroidetes L DNA lyase - - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_164262_2 1144313.PMI10_04189 2.1e-08 52.4 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1I2UG@117743|Flavobacteriia,2NWNB@237|Flavobacterium 976|Bacteroidetes L single-stranded DNA-binding protein - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_697873_1 886293.Sinac_6971 2.58e-62 218.0 COG1082@1|root,COG2010@1|root,COG2133@1|root,COG3241@1|root,COG1082@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3241@2|Bacteria,2IYH1@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c - - - - - - - - - - - - AP_endonuc_2,Cytochrom_C,Cytochrome_CBB3,Laminin_G_3,ThuA k59_588710_1 1117647.M5M_08975 1.75e-27 109.0 COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,1RNEY@1236|Gammaproteobacteria,1J75V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon corR - - ko:K04333 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - GerE k59_878390_1 296591.Bpro_4191 3.24e-10 57.4 COG2050@1|root,COG2050@2|Bacteria,1MYE0@1224|Proteobacteria,2WFMX@28216|Betaproteobacteria,4AEDY@80864|Comamonadaceae 28216|Betaproteobacteria Q Domain of unknown function (DUF4442) - - - - - - - - - - - - 4HBT k59_878390_2 614083.AWQR01000006_gene274 2.26e-104 311.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHD3@28216|Betaproteobacteria,4A9Q4@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_843669_1 1094466.KQS_00985 2.18e-25 102.0 COG0806@1|root,COG0806@2|Bacteria,4NQF0@976|Bacteroidetes,1I17F@117743|Flavobacteriia,2NUI5@237|Flavobacterium 976|Bacteroidetes J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_843669_2 1203611.KB894554_gene2811 1.47e-09 57.8 COG4123@1|root,COG4123@2|Bacteria,4NG1X@976|Bacteroidetes,2FMHH@200643|Bacteroidia,22VAW@171550|Rikenellaceae 976|Bacteroidetes J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) smtA GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016430,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS k59_355776_1 1000565.METUNv1_01173 4.75e-165 464.0 COG1262@1|root,COG1262@2|Bacteria,1Q227@1224|Proteobacteria,2VSH1@28216|Betaproteobacteria,2KX4T@206389|Rhodocyclales 206389|Rhodocyclales S SapC - - - - - - - - - - - - SapC k59_767645_1 365044.Pnap_3481 2.38e-82 247.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,4ABPU@80864|Comamonadaceae 28216|Betaproteobacteria M Bacterial sugar transferase - - - ko:K13012 - - - - ko00000,ko01005 - - - Bac_transf k59_677724_1 585502.HMPREF0645_2609 1.15e-109 340.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,2FRI5@200643|Bacteroidia 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_843698_1 985255.APHJ01000021_gene1393 3.64e-33 125.0 COG3177@1|root,COG3177@2|Bacteria,4NF0H@976|Bacteroidetes,1HZFZ@117743|Flavobacteriia,2P74K@244698|Gillisia 976|Bacteroidetes S Domain of unknown function (DUF4172) - - - - - - - - - - - - DUF4172,Fic k59_21374_1 1297863.APJF01000022_gene4416 2.89e-103 318.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,3JSTW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family MA20_38000 - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1061717_1 1123255.JHYS01000006_gene248 3.57e-54 170.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,4AECN@80864|Comamonadaceae 28216|Betaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_1061717_2 365046.Rta_29130 5.92e-28 108.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,4A9VJ@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_983246_1 864073.HFRIS_005983 1.92e-54 182.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHD2@28216|Betaproteobacteria,4761K@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP of the major facilitator superfamily citA - - - - - - - - - - - MFS_1,Sugar_tr k59_983246_2 757424.Hsero_1459 5.67e-14 70.9 COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2VJ7W@28216|Betaproteobacteria,4744J@75682|Oxalobacteraceae 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein - - 5.3.3.7 ko:K22003 ko00660,map00660 - R02244 RC00668 ko00000,ko00001,ko01000 - - - SBP_bac_11 k59_808124_1 1198452.Jab_1c17440 3.61e-112 327.0 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,2VMUW@28216|Betaproteobacteria,475ES@75682|Oxalobacteraceae 28216|Betaproteobacteria T signal transduction - - - - - - - - - - - - HDOD k59_412796_1 393595.ABO_0056 1.15e-14 75.9 2DQ64@1|root,334XE@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4393 k59_534552_1 640081.Dsui_1643 6.06e-29 114.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KWCJ@206389|Rhodocyclales 206389|Rhodocyclales P NnrS protein - - - ko:K07234 - - - - ko00000 - - - NnrS k59_878431_1 62928.azo2826 2.08e-59 190.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,2KUHS@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1095008_1 1454004.AW11_01617 2.59e-81 248.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1KPN9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_231258_1 929713.NIASO_06540 5.27e-114 332.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,1INNM@117747|Sphingobacteriia 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_381525_1 1231336.L248_2102 7.97e-11 68.2 COG1479@1|root,COG1479@2|Bacteria,1TPAT@1239|Firmicutes,4HBR3@91061|Bacilli,3F51D@33958|Lactobacillaceae 91061|Bacilli S Protein of unknown function DUF262 - - - - - - - - - - - - DUF1524,DUF262 k59_92908_1 1201290.M902_0280 1.48e-35 127.0 COG1714@1|root,COG1714@2|Bacteria,1NJXQ@1224|Proteobacteria,42XN4@68525|delta/epsilon subdivisions,2WSKW@28221|Deltaproteobacteria 28221|Deltaproteobacteria S RDD family - - - - - - - - - - - - RDD k59_311089_1 700598.Niako_5809 6.28e-11 62.4 COG1309@1|root,COG1309@2|Bacteria,4NQ99@976|Bacteroidetes,1ISRH@117747|Sphingobacteriia 976|Bacteroidetes K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_677789_1 1221522.B723_25775 5.25e-24 104.0 COG2878@1|root,COG3064@1|root,COG2878@2|Bacteria,COG3064@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1YN8A@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria CM Part of a membrane complex involved in electron transport rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_231266_1 1122951.ATUE01000007_gene543 4.01e-141 412.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,3NQU7@468|Moraxellaceae 1236|Gammaproteobacteria E HMGL-like leuA GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0066 HMGL-like,LeuA_dimer k59_462947_1 1538295.JY96_13690 1.47e-126 370.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1KJKX@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Belongs to the thiolase family fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_1061812_1 296591.Bpro_0266 7.65e-89 263.0 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2VQDH@28216|Betaproteobacteria,4ABE4@80864|Comamonadaceae 28216|Betaproteobacteria O Redoxin domain protein ahp1 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Redoxin k59_1061812_2 365044.Pnap_0217 1.9e-60 189.0 COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,2VT2S@28216|Betaproteobacteria,4ADIM@80864|Comamonadaceae 28216|Betaproteobacteria CO Redoxin domain protein resA_2 - - - - - - - - - - - AhpC-TSA,Redoxin k59_211346_1 1121403.AUCV01000013_gene3974 2.11e-10 67.8 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MPM4@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - DUF3365,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,PilJ,Response_reg,dCache_1 k59_622287_1 1144319.PMI16_04576 2.27e-25 102.0 COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VJA3@28216|Betaproteobacteria,472B7@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_622287_2 864073.HFRIS_002569 1.59e-124 360.0 COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKMU@28216|Betaproteobacteria,478D0@75682|Oxalobacteraceae 28216|Betaproteobacteria E branched-chain amino acid - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1061826_1 1121015.N789_12940 2.5e-51 175.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_697987_2 1219065.VPR01S_18_00220 1.87e-48 178.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1XTTM@135623|Vibrionales 135623|Vibrionales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_677873_1 243231.GSU1251 9.04e-06 54.7 COG1361@1|root,COG2372@1|root,COG4447@1|root,COG5184@1|root,COG1361@2|Bacteria,COG2372@2|Bacteria,COG4447@2|Bacteria,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,43VN4@69541|Desulfuromonadales 28221|Deltaproteobacteria DZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - RCC1 k59_697993_2 1288963.ADIS_4035 1.2e-75 243.0 COG0470@1|root,COG4916@1|root,COG0470@2|Bacteria,COG4916@2|Bacteria,4NW38@976|Bacteroidetes 976|Bacteroidetes L TIR domain - - - - - - - - - - - - TIR_2 k59_1095053_1 861299.J421_6243 5.83e-13 74.7 COG4888@1|root,COG4888@2|Bacteria,1ZURG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_1095054_1 614083.AWQR01000035_gene3620 8.88e-44 156.0 COG0277@1|root,COG0277@2|Bacteria,1NB6A@1224|Proteobacteria,2VI2Q@28216|Betaproteobacteria,4AGX4@80864|Comamonadaceae 28216|Betaproteobacteria C D-arabinono-1,4-lactone oxidase - - - - - - - - - - - - ALO,FAD_binding_4 k59_21474_1 1123277.KB893183_gene77 3.12e-09 59.7 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,47Y7Y@768503|Cytophagia 976|Bacteroidetes H PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_843817_1 589865.DaAHT2_1258 2.01e-52 186.0 COG3378@1|root,COG4643@1|root,COG3378@2|Bacteria,COG4643@2|Bacteria,1MVGY@1224|Proteobacteria,43AV4@68525|delta/epsilon subdivisions,2X696@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Toprim domain - - - ko:K06919 - - - - ko00000 - - - Toprim_3 k59_808225_1 867902.Ornrh_2220 5.98e-20 85.5 arCOG14922@1|root,32SW8@2|Bacteria,4NR3Q@976|Bacteroidetes,1I38N@117743|Flavobacteriia 976|Bacteroidetes S Copper resistance protein - - - - - - - - - - - - CopD k59_736018_1 1198452.Jab_2c09530 9.76e-61 207.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria,478GF@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_736024_1 641149.HMPREF9016_01175 9.23e-09 59.3 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,2VN8K@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_23026_1 1198452.Jab_1c10250 4.88e-118 350.0 COG0477@1|root,COG2814@2|Bacteria,1R3YS@1224|Proteobacteria,2VQBS@28216|Betaproteobacteria,473XW@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_59356_1 1005048.CFU_0012 1.81e-90 271.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,2VI9G@28216|Betaproteobacteria,475I2@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short k59_1127189_1 1000565.METUNv1_01882 1.37e-172 486.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,2KVM3@206389|Rhodocyclales 206389|Rhodocyclales F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_699814_1 397945.Aave_1155 9.19e-92 276.0 COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,4ACUT@80864|Comamonadaceae 28216|Betaproteobacteria E Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety kynA GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase k59_623686_1 929713.NIASO_00640 9.61e-12 64.3 COG0026@1|root,COG0026@2|Bacteria,4NEGE@976|Bacteroidetes,1IQSA@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_623686_2 714943.Mucpa_3715 4.13e-05 48.9 COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,4NH18@976|Bacteroidetes,1IQRP@117747|Sphingobacteriia 976|Bacteroidetes M glycosyl transferase family 2 - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1 k59_947459_1 1000565.METUNv1_03729 2.24e-83 264.0 2EE5J@1|root,33803@2|Bacteria,1NB1A@1224|Proteobacteria,2VVPM@28216|Betaproteobacteria,2KZEK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_985172_1 1144342.PMI40_00686 6.33e-39 134.0 COG1522@1|root,COG1522@2|Bacteria,1RH53@1224|Proteobacteria,2VRCQ@28216|Betaproteobacteria,4754C@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_809787_1 468059.AUHA01000002_gene374 7.61e-55 185.0 COG0356@1|root,COG0356@2|Bacteria,4NEPK@976|Bacteroidetes,1IPTF@117747|Sphingobacteriia 976|Bacteroidetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1127204_1 78398.KS43_09290 2.12e-72 233.0 COG2211@1|root,COG2211@2|Bacteria,1MWT1@1224|Proteobacteria,1RMID@1236|Gammaproteobacteria,1MQPC@122277|Pectobacterium 1236|Gammaproteobacteria G MFS/sugar transport protein melB1_1 - - ko:K03292,ko:K16210 - - - - ko00000,ko02000 2.A.2,2.A.2.5 - - MFS_2 k59_384401_1 1255043.TVNIR_1459 9.19e-54 190.0 COG1353@1|root,COG1353@2|Bacteria,1NB2Y@1224|Proteobacteria,1SK74@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM CRISPR-associated protein, Csm1 family - - - ko:K07016 - - - - ko00000,ko02048 - - - - k59_880273_1 1122951.ATUE01000005_gene1561 1.42e-116 357.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,3NJJI@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1023685_1 1189620.AJXL01000130_gene1664 8.56e-38 133.0 COG1752@1|root,COG1752@2|Bacteria,4NERH@976|Bacteroidetes,1HZ38@117743|Flavobacteriia,2NV4H@237|Flavobacterium 976|Bacteroidetes S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1023685_2 1267211.KI669560_gene1244 1.11e-50 171.0 COG0427@1|root,COG0427@2|Bacteria,4NFS3@976|Bacteroidetes,1IPAZ@117747|Sphingobacteriia 976|Bacteroidetes C acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_914954_1 614083.AWQR01000018_gene1875 1.65e-120 359.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,4AB6G@80864|Comamonadaceae 28216|Betaproteobacteria I Poly(R)-hydroxyalkanoic acid synthase, class I phbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_985184_1 1000565.METUNv1_03777 2.53e-53 177.0 COG0457@1|root,COG0457@2|Bacteria,1PV50@1224|Proteobacteria,2W9UK@28216|Betaproteobacteria,2KZF4@206389|Rhodocyclales 206389|Rhodocyclales S TPR repeat - - - - - - - - - - - - - k59_144071_1 1000565.METUNv1_00329 4.29e-118 350.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,2KURS@206389|Rhodocyclales 206389|Rhodocyclales J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_501676_1 883126.HMPREF9710_00765 5.62e-120 359.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,473NG@75682|Oxalobacteraceae 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_251319_1 1157708.KB907452_gene3548 1.62e-101 307.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4ABID@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family mucD - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1107702_1 357808.RoseRS_0753 2.26e-09 58.5 COG1131@1|root,COG1131@2|Bacteria,2G6IS@200795|Chloroflexi,375MP@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter related - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_1036541_1 1122951.ATUE01000006_gene1508 7.52e-62 202.0 COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G gluconolactonase - - - - - - - - - - - - Str_synth k59_679297_1 59538.XP_005977028.1 1.09e-61 207.0 COG3158@1|root,2QPSA@2759|Eukaryota,39UPB@33154|Opisthokonta,3BTMW@33208|Metazoa,3DA5P@33213|Bilateria 33208|Metazoa P K+ potassium transporter - - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - K_trans,RuvC k59_1424_1 1000565.METUNv1_01123 3.88e-199 557.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,2KUMJ@206389|Rhodocyclales 206389|Rhodocyclales S AFG1-like ATPase afg - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_1424_2 1000565.METUNv1_01122 2.23e-247 686.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUQ1@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1107712_1 714943.Mucpa_5248 5.13e-70 218.0 COG0378@1|root,COG0378@2|Bacteria,4NJ0P@976|Bacteroidetes,1IR6X@117747|Sphingobacteriia 976|Bacteroidetes KO COGs COG0378 Ni2 -binding GTPase involved in regulation of expression and maturation of urease and hydrogenase hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_1107712_2 871963.Desdi_2536 7.92e-08 53.1 COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,260CF@186807|Peptococcaceae 186801|Clostridia O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1072801_1 1000565.METUNv1_02144 1.26e-06 49.3 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,2KUNP@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1072801_2 1000565.METUNv1_02145 9.99e-63 201.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria,2KUG3@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_822252_1 1122137.AQXF01000002_gene393 5.65e-36 137.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family sun1 - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F k59_251343_1 1000565.METUNv1_03875 9.92e-43 158.0 COG3210@1|root,COG3210@2|Bacteria,1QDZF@1224|Proteobacteria,2VPRR@28216|Betaproteobacteria,2KZTG@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Haemagg_act k59_358535_3 194699.PORTL_BPBPP 9.75e-27 108.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_1036566_1 1000565.METUNv1_00923 5.32e-114 334.0 COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2VI9B@28216|Betaproteobacteria,2KZRN@206389|Rhodocyclales 206389|Rhodocyclales S Membrane transport protein - - - - - - - - - - - - Mem_trans k59_144091_2 864051.BurJ1DRAFT_1012 2.54e-27 104.0 COG2361@1|root,COG2361@2|Bacteria,1NDJN@1224|Proteobacteria,2VVNQ@28216|Betaproteobacteria,1KMKU@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function DUF86 - - - - - - - - - - - - - k59_394196_1 314278.NB231_12439 9.07e-73 224.0 29IBX@1|root,30593@2|Bacteria,1NUXA@1224|Proteobacteria,1SNHP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_394196_2 684949.ATTJ01000001_gene1349 5.87e-92 273.0 COG3680@1|root,COG3680@2|Bacteria 2|Bacteria O regulation of methylation-dependent chromatin silencing - - 3.1.13.5 ko:K03684,ko:K09968 - - - - ko00000,ko01000,ko03016 - - - - k59_394196_3 1121921.KB898706_gene2286 1.69e-13 69.3 COG3666@1|root,COG3666@2|Bacteria,1N7RF@1224|Proteobacteria,1SE1U@1236|Gammaproteobacteria,2PQM7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6 k59_1072831_1 65497.JODV01000038_gene1395 1.71e-10 66.6 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4E8XQ@85010|Pseudonocardiales 201174|Actinobacteria Q Condensation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_37193_1 1000565.METUNv1_01462 2.26e-95 293.0 COG0664@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,2KX5A@206389|Rhodocyclales 206389|Rhodocyclales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_394204_1 1207076.ALAT01000207_gene1726 2.43e-116 337.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Aspartyl Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox k59_394204_2 1089547.KB913014_gene4871 5.9e-17 82.8 COG2274@1|root,COG2274@2|Bacteria,4NH0Y@976|Bacteroidetes,47U40@768503|Cytophagia 976|Bacteroidetes V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_715482_1 757424.Hsero_0733 5.5e-83 261.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,47581@75682|Oxalobacteraceae 28216|Betaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_857720_1 365046.Rta_05290 3.48e-22 90.1 COG0526@1|root,COG0526@2|Bacteria,1N8B0@1224|Proteobacteria,2VW5T@28216|Betaproteobacteria,4AEW1@80864|Comamonadaceae 28216|Betaproteobacteria CO PFAM Thioredoxin - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Thioredoxin k59_1036594_1 272560.BPSL3406 6.18e-62 196.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,1JZVF@119060|Burkholderiaceae 28216|Betaproteobacteria D PFAM Cobyrinic acid a,c-diamide synthase parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_645498_1 1000565.METUNv1_00127 2.93e-52 182.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_645498_2 1000565.METUNv1_00129 5.35e-152 434.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,2KW63@206389|Rhodocyclales 206389|Rhodocyclales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_252221_1 1242864.D187_009114 9.42e-08 60.5 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase k59_716289_1 1123248.KB893319_gene4072 6.82e-22 99.0 COG0465@1|root,COG0465@2|Bacteria,4NF0E@976|Bacteroidetes,1IQ2Z@117747|Sphingobacteriia 976|Bacteroidetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_2078_1 1000565.METUNv1_00361 1.62e-190 536.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 206389|Rhodocyclales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_2078_2 335283.Neut_0412 4.35e-12 67.8 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,3722A@32003|Nitrosomonadales 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_716296_2 358220.C380_03785 5.86e-87 263.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,4ABPQ@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_359386_1 296591.Bpro_3158 2.66e-28 119.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,4AA8Y@80864|Comamonadaceae 28216|Betaproteobacteria S DNA internalization-related competence protein ComEC Rec2 comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_645513_1 682795.AciX8_1073 6.12e-23 98.6 COG2357@1|root,COG2357@2|Bacteria 2|Bacteria S guanosine tetraphosphate metabolic process - - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT k59_679937_1 204773.HEAR1041 3.95e-129 379.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,472WK@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_645514_1 1000565.METUNv1_00077 1.56e-103 310.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KUFP@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_181397_1 1000565.METUNv1_02046 9.72e-192 549.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,2KVMW@206389|Rhodocyclales 206389|Rhodocyclales K RNB - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_645519_1 1163617.SCD_n00301 1.67e-11 65.1 28KE4@1|root,2ZA0D@2|Bacteria,1MXZT@1224|Proteobacteria,2VNI6@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_645519_2 1163617.SCD_n00302 3.3e-56 187.0 COG0672@1|root,COG0672@2|Bacteria,1MXHM@1224|Proteobacteria,2WF1G@28216|Betaproteobacteria 28216|Betaproteobacteria P Psort location CytoplasmicMembrane, score efeU - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 k59_287935_1 1123504.JQKD01000002_gene3996 5.14e-38 139.0 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae 28216|Betaproteobacteria E FAD dependent oxidoreductase - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_858376_1 929703.KE386491_gene117 7.22e-90 278.0 COG1236@1|root,COG1236@2|Bacteria,4NESD@976|Bacteroidetes,47K9F@768503|Cytophagia 976|Bacteroidetes J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL k59_1037465_1 1000565.METUNv1_00269 5.19e-52 176.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales 206389|Rhodocyclales C Domain of unknown function (DUF3390) - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_395029_1 404589.Anae109_0103 1.34e-11 67.8 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,438BA@68525|delta/epsilon subdivisions,2X3KK@28221|Deltaproteobacteria,2YWFN@29|Myxococcales 28221|Deltaproteobacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_1037469_1 1000565.METUNv1_00878 4.4e-172 485.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,2KUG8@206389|Rhodocyclales 206389|Rhodocyclales G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_894623_1 1000565.METUNv1_00696 2.26e-268 737.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,2KUZF@206389|Rhodocyclales 206389|Rhodocyclales E Aminotransferase tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_716334_1 1000565.METUNv1_01602 1.9e-56 181.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,2KW6J@206389|Rhodocyclales 206389|Rhodocyclales O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_716334_2 1000565.METUNv1_01601 1.24e-33 121.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,2KW4C@206389|Rhodocyclales 206389|Rhodocyclales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_287960_1 1000565.METUNv1_01927 1.2e-134 402.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_572838_1 1123073.KB899245_gene117 1.57e-29 112.0 COG4359@1|root,COG4359@2|Bacteria,1REUD@1224|Proteobacteria,1S47B@1236|Gammaproteobacteria,1X63D@135614|Xanthomonadales 135614|Xanthomonadales E Putative Phosphatase - - - - - - - - - - - - HAD k59_431314_1 1000565.METUNv1_00656 4.69e-63 194.0 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,2KX0C@206389|Rhodocyclales 206389|Rhodocyclales S MazG-like family - - - - - - - - - - - - MazG-like k59_431314_2 990285.RGCCGE502_20255 5.34e-11 63.5 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,4B8TI@82115|Rhizobiaceae 28211|Alphaproteobacteria P Transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_324347_1 1158292.JPOE01000002_gene2331 1.24e-68 231.0 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VJ7D@28216|Betaproteobacteria,1KM6H@119065|unclassified Burkholderiales 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_1073966_1 1000565.METUNv1_00802 5.65e-85 254.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria,2KWA8@206389|Rhodocyclales 206389|Rhodocyclales L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_965561_1 614083.AWQR01000053_gene3395 9.57e-115 351.0 COG5322@1|root,COG5322@2|Bacteria,1R60X@1224|Proteobacteria 1224|Proteobacteria S oxidoreductase activity - - - - - - - - - - - - Semialdhyde_dh k59_858406_1 1000565.METUNv1_03311 1.23e-35 126.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,2KWSF@206389|Rhodocyclales 206389|Rhodocyclales O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_858406_2 1000565.METUNv1_03312 3.62e-15 74.3 COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,2KWVJ@206389|Rhodocyclales 206389|Rhodocyclales D cell division protein ftsN - - - - - - - - - - - SPOR k59_287969_1 1000565.METUNv1_01503 1.21e-112 334.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,2KUX0@206389|Rhodocyclales 206389|Rhodocyclales C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_181457_1 1100721.ALKO01000030_gene83 2.27e-60 202.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2VJHS@28216|Betaproteobacteria,4AA9C@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Sulfatase - - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_324368_1 1100721.ALKO01000016_gene1479 6.93e-115 339.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_502889_1 1530186.JQEY01000002_gene1497 5.6e-06 48.1 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the LOG family yvdD - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_502889_2 420662.Mpe_A2180 1.78e-38 132.0 2EKZU@1|root,33EPA@2|Bacteria,1NNWE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_572855_1 1000565.METUNv1_02870 4.9e-107 329.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,2KVTG@206389|Rhodocyclales 206389|Rhodocyclales D DNA segregation ATPase FtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_109089_1 1000565.METUNv1_03643 2.21e-136 390.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,2KUNS@206389|Rhodocyclales 206389|Rhodocyclales S ABC-type (Unclassified) transport system, ATPase component - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_679991_1 1121035.AUCH01000007_gene598 1.37e-37 137.0 COG0614@1|root,COG0614@2|Bacteria,1PK1M@1224|Proteobacteria,2W9TE@28216|Betaproteobacteria,2KZAE@206389|Rhodocyclales 206389|Rhodocyclales P Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_2 k59_38133_1 365044.Pnap_1616 3.29e-82 261.0 COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria,4AB9X@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_502896_2 469660.A8HNZ9_9CAUD 1.65e-28 110.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_502896_3 1161931.J7F8X6_9CAUD 5.62e-68 229.0 4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses no RNA stage,4QR8A@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_1108447_2 1000565.METUNv1_02277 1.19e-53 169.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,2KX1F@206389|Rhodocyclales 206389|Rhodocyclales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_1108447_3 159087.Daro_0333 6.14e-18 77.8 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,2KWAI@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_929633_1 1157708.KB907452_gene3770 1.21e-61 202.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VIY2@28216|Betaproteobacteria,4AB91@80864|Comamonadaceae 28216|Betaproteobacteria M glycosyl transferase family 2 gtrB - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_109113_1 468059.AUHA01000005_gene2437 2.88e-101 297.0 COG0664@1|root,COG0664@2|Bacteria,4NFIS@976|Bacteroidetes,1ISBB@117747|Sphingobacteriia 976|Bacteroidetes K Crp-like helix-turn-helix domain - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_38157_1 1000565.METUNv1_03305 6.83e-87 267.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,2KUUJ@206389|Rhodocyclales 206389|Rhodocyclales H Aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_502917_1 1000565.METUNv1_00752 1.23e-254 699.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,2KVXU@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_144822_1 666681.M301_1811 1.87e-63 202.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria 28216|Betaproteobacteria Q dienelactone hydrolase clcD - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_252347_1 1000565.METUNv1_00562 1.35e-242 670.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,2KUBJ@206389|Rhodocyclales 206389|Rhodocyclales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_894694_1 7213.XP_004532995.1 2.42e-72 238.0 COG0318@1|root,KOG1176@2759|Eukaryota 2759|Eukaryota IQ ligase activity - GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009820,GO:0009821,GO:0009987,GO:0017144,GO:0018130,GO:0018904,GO:0019748,GO:0034641,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044550,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1900794,GO:1900796,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901503,GO:1901510,GO:1901512,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 - - - - - - - - - - AMP-binding,PP-binding,Thioesterase k59_894694_2 322710.Avin_44260 2.21e-26 105.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity JD73_00815 - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_431392_1 614083.AWQR01000013_gene1685 5.63e-146 416.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,4A9J5@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_725068_36 1121004.ATVC01000007_gene1154 1.48e-60 191.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KQZB@206351|Neisseriales 206351|Neisseriales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_725068_37 1073999.BN137_1198 3.02e-67 223.0 COG0468@1|root,COG0468@2|Bacteria,1PK58@1224|Proteobacteria,1RYHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L AAA domain - - - - - - - - - - - - AAA_24 k59_725068_41 563031.HMPREF0666_01114 1.62e-33 125.0 2DGN9@1|root,2ZWNI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_339347_1 1348657.M622_15240 2.52e-25 97.8 COG2253@1|root,COG2253@2|Bacteria,1NJT9@1224|Proteobacteria,2VNGB@28216|Betaproteobacteria 28216|Betaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_339347_2 1268622.AVS7_02395 7.62e-62 194.0 COG5340@1|root,COG5340@2|Bacteria,1P6MT@1224|Proteobacteria,2VPJY@28216|Betaproteobacteria,4ADUI@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_1,AbiEi_3_N,AbiEi_4 k59_11413_1 1000565.METUNv1_01559 5.42e-62 195.0 28JVR@1|root,2Z9KN@2|Bacteria,1R7WT@1224|Proteobacteria,2VQRD@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_11413_2 1223521.BBJX01000010_gene80 1.22e-58 196.0 COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,2VNRY@28216|Betaproteobacteria,4ABYW@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262 k59_47790_1 1000565.METUNv1_03149 1.53e-141 403.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,2KV3I@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease/Exonuclease/phosphatase family xthA2 - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_47790_2 1159870.KB907784_gene1526 3.82e-11 61.6 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,3T1TR@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_688135_1 1123367.C666_07085 3.16e-84 274.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KUIU@206389|Rhodocyclales 206389|Rhodocyclales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_476024_2 1123277.KB893210_gene2872 4.38e-20 87.4 COG3394@1|root,COG3394@2|Bacteria,4PNAT@976|Bacteroidetes,47TGM@768503|Cytophagia 976|Bacteroidetes G YdjC-like protein - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC k59_404253_1 981336.F944_01792 7.31e-94 301.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,3NIFC@468|Moraxellaceae 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_867790_1 748247.AZKH_1408 5.27e-10 58.9 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VHHK@28216|Betaproteobacteria,2KVWE@206389|Rhodocyclales 206389|Rhodocyclales L impB/mucB/samB family rumB - - ko:K03502 - - - - ko00000,ko03400 - - - DUF4113,IMS,IMS_C k59_867790_2 637389.Acaty_c0228 1.01e-36 130.0 COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,1S5X5@1236|Gammaproteobacteria,2ND6V@225057|Acidithiobacillales 225057|Acidithiobacillales KT Peptidase S24-like - - - ko:K03503 - - - - ko00000,ko01000,ko01002,ko03400 - - - Peptidase_S24 k59_11418_1 10689.H9C0F1_BPCPT 4.58e-08 55.1 4QGW7@10239|Viruses,4QZSG@35237|dsDNA viruses no RNA stage,4QPVG@28883|Caudovirales,4QK98@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_867791_1 743720.Psefu_3889 2.96e-22 101.0 28IPV@1|root,2Z8PP@2|Bacteria,1R6QJ@1224|Proteobacteria,1S0TA@1236|Gammaproteobacteria,1YX6U@136845|Pseudomonas putida group 1236|Gammaproteobacteria M C-terminal carbohydrate-binding module - - - ko:K19293 - - - - ko00000 - - - ALGX,CBM_26 k59_262343_1 158500.BV97_03745 1.12e-60 204.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2TU4W@28211|Alphaproteobacteria,2K1Y2@204457|Sphingomonadales 204457|Sphingomonadales KL COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_973506_1 887062.HGR_06561 8.38e-102 316.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,4AA8W@80864|Comamonadaceae 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_661698_2 1123487.KB892864_gene2078 4.7e-52 168.0 COG4922@1|root,COG4922@2|Bacteria,1RJ34@1224|Proteobacteria,2VV8P@28216|Betaproteobacteria 28216|Betaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_154318_1 55207.KP22_06625 1.3e-56 181.0 28J11@1|root,2Z8Y4@2|Bacteria,1R54Z@1224|Proteobacteria,1RQAZ@1236|Gammaproteobacteria,1MTJ1@122277|Pectobacterium 1236|Gammaproteobacteria S Protein of unknown function (DUF3486) - - - - - - - - - - - - DUF3486 k59_154318_2 598467.BrE312_3271 3.64e-50 160.0 2DTJ9@1|root,32UVD@2|Bacteria,1MZG4@1224|Proteobacteria,1S65F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_154318_3 1166016.W5S_2886 1.8e-30 112.0 2E2XA@1|root,32XYA@2|Bacteria,1MZYV@1224|Proteobacteria,1S5S2@1236|Gammaproteobacteria,1MSKY@122277|Pectobacterium 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_154318_4 1238190.AMQY01000014_gene878 3.65e-10 58.2 COG1734@1|root,COG1734@2|Bacteria,1MZIB@1224|Proteobacteria,1S8SP@1236|Gammaproteobacteria,1XM3C@135619|Oceanospirillales 135619|Oceanospirillales T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_614706_1 1100720.ALKN01000031_gene1286 2.22e-24 103.0 2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,2VR1F@28216|Betaproteobacteria,4AE93@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1011643_1 987059.RBXJA2T_05743 5.01e-74 234.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,2WEG5@28216|Betaproteobacteria,1KNUZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_833405_1 1000565.METUNv1_02081 9.89e-153 438.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,2KVNS@206389|Rhodocyclales 206389|Rhodocyclales I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_405610_1 1415755.JQLV01000001_gene2307 9.48e-71 222.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1XITV@135619|Oceanospirillales 135619|Oceanospirillales O DnaJ C terminal domain cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_405610_2 1288826.MSNKSG1_03265 1.13e-129 377.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,4652T@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1230 Co Zn Cd efflux system component - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_1117963_1 946483.Cenrod_0675 8.38e-33 123.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,4AATS@80864|Comamonadaceae 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - FHA,Guanylate_cyc k59_264217_2 1357272.AVEO02000145_gene1387 1.44e-22 92.8 28ZJ6@1|root,2ZMAJ@2|Bacteria,1P8MZ@1224|Proteobacteria,1SVPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_800006_1 762968.HMPREF9441_02261 6.08e-43 154.0 COG0707@1|root,COG0707@2|Bacteria,4PKSS@976|Bacteroidetes,2FMCT@200643|Bacteroidia 976|Bacteroidetes M Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Glyco_trans_1_3 k59_939176_1 314278.NB231_08973 3.62e-120 362.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1WWF0@135613|Chromatiales 1236|Gammaproteobacteria I Acyltransferase JD73_00810 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C_2,PP-binding k59_199692_1 1198452.Jab_1c23540 3.67e-75 238.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2VJUS@28216|Betaproteobacteria,478PH@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1048793_1 382464.ABSI01000013_gene1549 3.22e-20 95.1 COG2312@1|root,COG3211@1|root,COG2312@2|Bacteria,COG3211@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae 203494|Verrucomicrobiae C CotH kinase protein - - - - - - - - - - - - CHB_HEX_C_1,CotH,Fn3_assoc,LTD k59_477805_1 762376.AXYL_05799 3.92e-52 176.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,3T25P@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase - - - - - - - - - - - - CoA_transf_3 k59_477805_2 1123504.JQKD01000019_gene5549 5.79e-21 90.5 COG3181@1|root,COG3181@2|Bacteria,1R5YX@1224|Proteobacteria,2VMWM@28216|Betaproteobacteria,4AC22@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_405624_1 395495.Lcho_1065 1.1e-83 256.0 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2VSX2@28216|Betaproteobacteria,1KMKV@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_939185_1 929703.KE386491_gene406 1.54e-83 276.0 COG0841@1|root,COG0841@2|Bacteria,4NE3H@976|Bacteroidetes,47M3R@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_906148_1 1121035.AUCH01000027_gene3395 6.14e-97 296.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,2KVDJ@206389|Rhodocyclales 206389|Rhodocyclales M HlyD membrane-fusion protein of T1SS - - - ko:K12537,ko:K16300 - M00328,M00571 - - ko00000,ko00002,ko02000,ko02044 8.A.1,8.A.1.3.3 - - HlyD,HlyD_3 k59_372148_2 1000565.METUNv1_01200 2.29e-54 179.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,2VQY3@28216|Betaproteobacteria,2KXFS@206389|Rhodocyclales 206389|Rhodocyclales NU Prokaryotic N-terminal methylation motif - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_664537_1 1000565.METUNv1_02784 3.91e-155 444.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,2KU7F@206389|Rhodocyclales 206389|Rhodocyclales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_760800_1 1504672.669783879 3.91e-45 160.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,4AB8V@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit fdwB - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_760800_2 543728.Vapar_4072 1.55e-51 181.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,4AAQA@80864|Comamonadaceae 28216|Betaproteobacteria C formate dehydrogenase, alpha subunit fdhA1 - 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_49585_2 1000565.METUNv1_02107 4.7e-94 291.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,2KUSA@206389|Rhodocyclales 206389|Rhodocyclales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_264244_1 640510.BC1001_5906 7.54e-17 79.7 COG4678@1|root,COG4678@2|Bacteria,1N2BW@1224|Proteobacteria,2VVEP@28216|Betaproteobacteria,1KA0V@119060|Burkholderiaceae 28216|Betaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_939194_1 1245469.S58_33520 2.52e-29 120.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,3JRSC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_300920_2 1220714.L7TMV1_9CAUD 2.2e-61 204.0 4QEFV@10239|Viruses,4QYS7@35237|dsDNA viruses no RNA stage,4QRRT@28883|Caudovirales,4QJVQ@10662|Myoviridae 10662|Myoviridae S Pfam:Terminase_3C - - - - - - - - - - - - - k59_1118015_1 338969.Rfer_1274 4.58e-98 303.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,4A9WD@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_342352_1 755732.Fluta_1122 1.82e-24 100.0 COG0796@1|root,COG0796@2|Bacteria,4NG1C@976|Bacteroidetes,1HX4S@117743|Flavobacteriia,2PB1C@246874|Cryomorphaceae 976|Bacteroidetes M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_342352_2 938709.AUSH02000071_gene1666 5.42e-21 83.6 COG0230@1|root,COG0230@2|Bacteria,4NUTV@976|Bacteroidetes 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 k59_800052_1 278963.ATWD01000001_gene2789 4.47e-37 133.0 COG3970@1|root,COG3970@2|Bacteria,3Y6J7@57723|Acidobacteria,2JKPG@204432|Acidobacteriia 204432|Acidobacteriia S Fumarylacetoacetate (FAA) hydrolase family - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_224343_1 794903.OPIT5_14065 5.56e-09 61.2 COG2165@1|root,COG2165@2|Bacteria,46Y3N@74201|Verrucomicrobia,3K8VQ@414999|Opitutae 414999|Opitutae NU general secretion pathway protein - - - - - - - - - - - - - k59_664586_2 1122951.ATUE01000008_gene118 8.52e-65 213.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,3NJGP@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 GATase,GMP_synt_C,NAD_synthase k59_689973_1 1000565.METUNv1_03492 5.25e-29 110.0 COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,2VHXH@28216|Betaproteobacteria,2KVE9@206389|Rhodocyclales 206389|Rhodocyclales J Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureD - - ko:K03190 - - - - ko00000 - - - UreD k59_689973_3 1000565.METUNv1_03490 3.33e-39 132.0 2E77W@1|root,331RM@2|Bacteria,1NC8J@1224|Proteobacteria,2VXEM@28216|Betaproteobacteria,2KXKE@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_689973_4 1000565.METUNv1_03489 3.3e-62 191.0 COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,2VSGJ@28216|Betaproteobacteria,2KWUI@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the urease beta subunit family ureB - 3.5.1.5 ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta k59_224348_1 391735.Veis_0460 2.98e-38 146.0 COG1520@1|root,COG4932@1|root,COG1520@2|Bacteria,COG4932@2|Bacteria,1PWKY@1224|Proteobacteria,2WC5C@28216|Betaproteobacteria,4AIVR@80864|Comamonadaceae 2|Bacteria IMQ domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CarboxypepD_reg,Flg_new,HSP70,Metallophos,PQQ_2 k59_581952_1 1005048.CFU_2980 1.78e-34 130.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,472PP@75682|Oxalobacteraceae 28216|Betaproteobacteria G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_581952_2 1198452.Jab_1c17180 3.4e-43 147.0 COG0395@1|root,COG0395@2|Bacteria,1R4GU@1224|Proteobacteria 1224|Proteobacteria P Binding-protein-dependent transport system inner membrane component ycjP_1 - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_342386_1 1120977.JHUX01000009_gene2644 2.85e-140 404.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,1S1Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_342391_1 344747.PM8797T_26725 7.37e-57 203.0 COG2010@1|root,COG2010@2|Bacteria,2IYM5@203682|Planctomycetes 203682|Planctomycetes C Protein of unknown function (DUF1549) - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_800077_1 194699.Q775D1_BPBPP 1.16e-140 422.0 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_49632_1 1223521.BBJX01000020_gene2939 6.22e-94 277.0 COG1247@1|root,COG1247@2|Bacteria,1QU6B@1224|Proteobacteria,2VM3N@28216|Betaproteobacteria,4A9S1@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_664625_1 999541.bgla_1g02060 4.57e-41 144.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,2VRPW@28216|Betaproteobacteria,1KFMH@119060|Burkholderiaceae 28216|Betaproteobacteria NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_869800_1 686340.Metal_0445 4.08e-52 186.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE8,EAL,GGDEF,HAMP k59_760853_1 1218084.BBJK01000126_gene7055 2.25e-64 214.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VNJ6@28216|Betaproteobacteria,1KFG3@119060|Burkholderiaceae 28216|Betaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C,YjgF_endoribonc k59_156263_1 929562.Emtol_2590 1.55e-99 321.0 COG1538@1|root,COG3696@1|root,COG1538@2|Bacteria,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47JC4@768503|Cytophagia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_199828_1 391735.Veis_1261 2.23e-94 295.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4AAAN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_13284_1 1235457.C404_21620 1.1e-82 264.0 2DBEH@1|root,2Z8SD@2|Bacteria,1R5GT@1224|Proteobacteria,2VMJ8@28216|Betaproteobacteria,1KB6Z@119060|Burkholderiaceae 28216|Betaproteobacteria E metalloendopeptidase activity dtmL - - - - - - - - - - - Peptidase_M66 k59_84706_1 580332.Slit_2160 1.02e-57 206.0 COG2199@1|root,COG2202@1|root,COG3447@1|root,COG3614@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG3447@2|Bacteria,COG3614@2|Bacteria,1NWNJ@1224|Proteobacteria,2WHIC@28216|Betaproteobacteria,44WDC@713636|Nitrosomonadales 28216|Betaproteobacteria T SMART GGDEF domain containing protein - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_975370_1 614083.AWQR01000014_gene2447 1.09e-159 460.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,4ABXM@80864|Comamonadaceae 28216|Betaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_156278_1 399795.CtesDRAFT_PD1079 5.44e-41 140.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,4AC2Q@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_1097903_1 3656.XP_008460615.1 3.75e-37 144.0 COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids 35493|Streptophyta H transposition, RNA-mediated - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,gag-asp_proteas,rve k59_1068770_1 1198452.Jab_1c07830 6.41e-64 216.0 COG4932@1|root,COG4932@2|Bacteria,1R2PP@1224|Proteobacteria,2WICC@28216|Betaproteobacteria 28216|Betaproteobacteria M domain protein - - - - - - - - - - - - - k59_849126_1 543728.Vapar_4088 8.16e-112 340.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria,4AA5E@80864|Comamonadaceae 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_883622_1 1538295.JY96_06730 4.32e-124 363.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1KJH9@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_988059_1 399741.Spro_2035 4.16e-11 59.7 COG4197@1|root,COG4197@2|Bacteria,1NBCG@1224|Proteobacteria,1SIAE@1236|Gammaproteobacteria,40572@613|Serratia 1236|Gammaproteobacteria S Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT - - - - - - - - - - - - YdaS_antitoxin k59_416904_1 1000565.METUNv1_03673 1.91e-69 226.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria,2KX5Q@206389|Rhodocyclales 28216|Betaproteobacteria U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_316897_1 296591.Bpro_0709 2.01e-95 285.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VRK9@28216|Betaproteobacteria 28216|Betaproteobacteria K Response regulator receiver - - - - - - - - - - - - GerE,Response_reg k59_316897_2 296591.Bpro_0708 2.04e-68 224.0 COG3447@1|root,COG4585@1|root,COG3447@2|Bacteria,COG4585@2|Bacteria,1PF0H@1224|Proteobacteria,2W8ZC@28216|Betaproteobacteria,4AI7H@80864|Comamonadaceae 28216|Betaproteobacteria T MASE1 - - - - - - - - - - - - HATPase_c,MASE1 k59_988067_1 614083.AWQR01000009_gene645 6.18e-79 239.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2W9BJ@28216|Betaproteobacteria,4AI45@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_988067_2 1100721.ALKO01000017_gene1646 8.32e-10 57.8 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2VKKB@28216|Betaproteobacteria,4AAE4@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_492732_1 296591.Bpro_3643 9.02e-101 297.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,4AA53@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_62007_1 29581.BW37_03346 7.12e-87 257.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,474CY@75682|Oxalobacteraceae 28216|Betaproteobacteria C [2Fe-2S] binding domain iorA - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_169097_1 382464.ABSI01000011_gene2413 4.27e-48 165.0 COG0627@1|root,COG0627@2|Bacteria 2|Bacteria J Serine hydrolase involved in the detoxification of formaldehyde - - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase,Hepar_II_III,Hepar_II_III_N k59_169097_2 452637.Oter_0344 4.13e-32 119.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds MA20_01735 - - - - - - - - - - - Abhydrolase_6 k59_97953_1 446465.Bfae_16080 4.08e-29 106.0 COG0140@1|root,COG0140@2|Bacteria,2IQ4D@201174|Actinobacteria,4FD60@85020|Dermabacteraceae 201174|Actinobacteria E Phosphoribosyl-ATP pyrophosphohydrolase hisE GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0071944,GO:0075136,GO:0075139 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_97953_2 105425.BBPL01000058_gene5022 7.39e-42 145.0 COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,2NFEW@228398|Streptacidiphilus 201174|Actinobacteria E ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_416921_1 595537.Varpa_4828 5.81e-175 493.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,4AA8G@80864|Comamonadaceae 28216|Betaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_133114_2 2903.EOD15031 8e-30 108.0 KOG0096@1|root,KOG0096@2759|Eukaryota 2759|Eukaryota A ribosome localization - GO:0000003,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0032501,GO:0032502,GO:0032504,GO:0044703,GO:0048468,GO:0048477,GO:0048609,GO:0048856,GO:0048869,GO:0051704 - ko:K07936 ko03008,ko03013,ko05166,ko05169,map03008,map03013,map05166,map05169 - - - ko00000,ko00001,ko03009,ko03016,ko03019,ko03036,ko04031,ko04147 - - - Ras k59_133117_2 1123368.AUIS01000024_gene956 1.12e-47 158.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,1RR26@1236|Gammaproteobacteria,2NC5V@225057|Acidithiobacillales 225057|Acidithiobacillales O Glutathione S-transferase, N-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N_3 k59_492779_2 338969.Rfer_0366 8.56e-69 232.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,4ABZ1@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_133119_2 269482.Bcep1808_7596 4.53e-34 130.0 COG3350@1|root,COG3350@2|Bacteria,1MWWK@1224|Proteobacteria,2VH88@28216|Betaproteobacteria,1K32E@119060|Burkholderiaceae 28216|Betaproteobacteria S YHS domain - - - ko:K16242 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002,ko01000 - - - Phenol_Hydrox,YHS k59_562775_1 1000565.METUNv1_02377 2.88e-189 548.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2WGQE@28216|Betaproteobacteria,2KUAH@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9 k59_562775_2 1000565.METUNv1_02376 7.2e-23 96.3 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KUN4@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_316965_2 1276756.AUEX01000007_gene1406 9.98e-38 132.0 COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,2VU18@28216|Betaproteobacteria,4AF6R@80864|Comamonadaceae 28216|Betaproteobacteria C Domain of unknown function (DUF1924) - - - - - - - - - - - - DUF1924 k59_771629_1 236097.ADG881_2866 5.72e-76 238.0 COG2866@1|root,COG2866@2|Bacteria,1NW73@1224|Proteobacteria,1RNBV@1236|Gammaproteobacteria,1XHPD@135619|Oceanospirillales 135619|Oceanospirillales E Protein of unknown function (DUF2817) - - - - - - - - - - - - Peptidase_M14 k59_388645_1 1502852.FG94_01328 7.13e-08 52.8 COG4106@1|root,COG4106@2|Bacteria,1QUZE@1224|Proteobacteria,2VSHF@28216|Betaproteobacteria,474Y9@75682|Oxalobacteraceae 28216|Betaproteobacteria S Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - TPMT k59_883741_1 1236976.JCM16418_4253 9.76e-12 70.5 COG1409@1|root,COG2041@1|root,COG3211@1|root,COG4733@1|root,COG1409@2|Bacteria,COG2041@2|Bacteria,COG3211@2|Bacteria,COG4733@2|Bacteria,1V7PQ@1239|Firmicutes,4IUC5@91061|Bacilli,277JF@186822|Paenibacillaceae 91061|Bacilli G Fibronectin type III domain - - - - - - - - - - - - F5_F8_type_C,SLH,fn3 k59_883744_2 412597.AEPN01000006_gene1555 1.02e-24 96.3 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2V4QC@28211|Alphaproteobacteria,2PY07@265|Paracoccus 28211|Alphaproteobacteria G Phage lysozyme - - - - - - - - - - - - Phage_lysozyme k59_133135_2 700598.Niako_6473 2.2e-10 61.6 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes,1IPBN@117747|Sphingobacteriia 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_988122_1 1267211.KI669560_gene2359 3.79e-59 192.0 COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,1IP3S@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_277852_1 247490.KSU1_C0714 1.78e-47 171.0 COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes 203682|Planctomycetes O alpha-L-arabinofuranosidase - - - - - - - - - - - - SBBP k59_812253_1 296591.Bpro_2871 1.06e-82 270.0 COG1196@1|root,COG1196@2|Bacteria,1R4SX@1224|Proteobacteria,2WGNF@28216|Betaproteobacteria,4AJWI@80864|Comamonadaceae 28216|Betaproteobacteria D Domain of Unknown Function (DUF349) - - - - - - - - - - - - DUF349 k59_277863_1 981336.F944_00770 2.34e-08 53.9 COG1733@1|root,COG1733@2|Bacteria,1RF0R@1224|Proteobacteria,1S4FX@1236|Gammaproteobacteria,3NKIF@468|Moraxellaceae 1236|Gammaproteobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_625894_1 1276756.AUEX01000001_gene1004 6.16e-32 121.0 COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,2VJN1@28216|Betaproteobacteria,4AAMZ@80864|Comamonadaceae 28216|Betaproteobacteria F Guanine deaminase guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1068945_1 1000565.METUNv1_02982 2.95e-98 306.0 COG0515@1|root,COG2114@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,2KWHB@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein kinase domain - - - - - - - - - - - - DUF4384,Pkinase k59_1130157_1 1538295.JY96_03830 4.16e-106 315.0 COG0715@1|root,COG0715@2|Bacteria,1QVPH@1224|Proteobacteria 1224|Proteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - - - - - - - - - - - k59_1068951_1 338969.Rfer_0544 3.06e-33 125.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,4A9SE@80864|Comamonadaceae 28216|Betaproteobacteria U General secretion pathway protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1130161_1 317619.ANKN01000038_gene71 1.16e-36 142.0 COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria 1117|Cyanobacteria CJ TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_702766_1 420662.Mpe_A2459 1.07e-20 89.7 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,2VQRP@28216|Betaproteobacteria,1KKK0@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_702766_2 543728.Vapar_3093 1.57e-47 155.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,4AA9Y@80864|Comamonadaceae 28216|Betaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_492847_1 232721.Ajs_2791 3.6e-76 236.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2VHC8@28216|Betaproteobacteria,4AA24@80864|Comamonadaceae 28216|Betaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_98036_1 522306.CAP2UW1_4286 1.4e-118 347.0 COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,2VMW2@28216|Betaproteobacteria 28216|Betaproteobacteria P Rhodanese domain protein dedA_2 - - - - - - - - - - - Rhodanese,SNARE_assoc k59_388710_1 1123504.JQKD01000033_gene5233 3.9e-73 230.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,4AAV9@80864|Comamonadaceae 28216|Betaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_277884_1 99598.Cal7507_0708 5.31e-26 108.0 COG5267@1|root,COG5267@2|Bacteria,1G0JB@1117|Cyanobacteria,1HM0D@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_277884_2 1500894.JQNN01000001_gene2785 3.1e-48 166.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2VH8S@28216|Betaproteobacteria,4734M@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501,TAT_signal k59_98043_1 983545.Glaag_0287 1.22e-30 118.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,467WK@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the DegT DnrJ EryC1 family per - - - - - - - - - - - DegT_DnrJ_EryC1 k59_917467_1 1124983.PFLCHA0_c45780 7.13e-107 333.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1YMF5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_883833_2 196367.JNFG01000199_gene3400 4.96e-10 60.8 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2WH2X@28216|Betaproteobacteria,1KIHC@119060|Burkholderiaceae 28216|Betaproteobacteria T Activator of aromatic catabolism - - - - - - - - - - - - HTH_8,Sigma54_activat,V4R,XylR_N k59_235156_1 1158292.JPOE01000005_gene1067 2.64e-16 75.1 28MTH@1|root,2ZB1P@2|Bacteria,1R6K1@1224|Proteobacteria,2VMVV@28216|Betaproteobacteria,1KMKY@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF4007) - - - - - - - - - - - - DUF4007 k59_235156_2 396588.Tgr7_1777 4.74e-97 288.0 COG5340@1|root,COG5340@2|Bacteria,1PFSA@1224|Proteobacteria,1SJHP@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_235156_3 396588.Tgr7_1776 8.83e-47 160.0 COG2253@1|root,COG2253@2|Bacteria,1PZRM@1224|Proteobacteria,1S18R@1236|Gammaproteobacteria,1WYHY@135613|Chromatiales 135613|Chromatiales S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_1026901_1 640081.Dsui_1772 1.26e-79 254.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2VHSJ@28216|Betaproteobacteria,2KUBT@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran k59_738672_1 1000565.METUNv1_03480 6.92e-99 310.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,2KVAV@206389|Rhodocyclales 206389|Rhodocyclales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_133208_1 1244869.H261_03768 2.29e-93 299.0 COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,2TRZK@28211|Alphaproteobacteria,2JTUY@204441|Rhodospirillales 204441|Rhodospirillales L Tn3 transposase DDE domain - - - - - - - - - - - - DDE_Tnp_Tn3,DUF4158 k59_388760_1 1122951.ATUE01000007_gene661 6.96e-88 277.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,3NJGS@468|Moraxellaceae 1236|Gammaproteobacteria P Transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_496690_4 1121033.AUCF01000003_gene3067 6.15e-16 77.4 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JPHR@204441|Rhodospirillales 204441|Rhodospirillales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_888273_1 1000565.METUNv1_00655 5e-113 354.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,2KVGD@206389|Rhodocyclales 206389|Rhodocyclales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_852810_1 1049564.TevJSym_ab01560 2.9e-36 139.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,1RNGS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - DUF2339 k59_172483_1 1000565.METUNv1_04063 3.42e-137 410.0 COG4206@1|root,COG4206@2|Bacteria,1QUWU@1224|Proteobacteria,2WGQG@28216|Betaproteobacteria,2KV16@206389|Rhodocyclales 206389|Rhodocyclales H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_888332_1 279714.FuraDRAFT_2191 3.05e-73 237.0 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,2KS8Z@206351|Neisseriales 206351|Neisseriales P Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase,CbiA k59_64983_1 887062.HGR_12192 1.93e-63 217.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,4A9NR@80864|Comamonadaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_172531_1 1304883.KI912532_gene79 3.46e-69 221.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2WGGJ@28216|Betaproteobacteria,2KUT8@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_172531_2 640081.Dsui_3186 3.23e-61 203.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KUPY@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_595440_1 6238.CBG25618 5.29e-06 52.0 KOG4185@1|root,KOG4185@2759|Eukaryota 2759|Eukaryota S zinc ion binding - GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006952,GO:0007275,GO:0007568,GO:0008150,GO:0008340,GO:0009605,GO:0009607,GO:0009617,GO:0010259,GO:0032501,GO:0032502,GO:0042742,GO:0043207,GO:0048856,GO:0050830,GO:0050896,GO:0051704,GO:0051707,GO:0098542 - - - - - - - - - - zf-B_box,zf-C3HC4,zf-RING_2,zf-RING_5,zf-RING_UBOX k59_320379_1 1000565.METUNv1_03868 1.48e-78 259.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,2KVBE@206389|Rhodocyclales 206389|Rhodocyclales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_852882_1 1173025.GEI7407_0339 1.16e-49 181.0 COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales 1117|Cyanobacteria M Tetratricopeptide repeat - - - - - - - - - - - - DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_101380_1 1123277.KB893179_gene3145 5.23e-27 108.0 COG4299@1|root,COG4299@2|Bacteria,4NDZF@976|Bacteroidetes,47JVV@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1624) - - - - - - - - - - - - DUF1624,DUF5009 k59_28731_1 614083.AWQR01000009_gene531 8.37e-57 182.0 COG0800@1|root,COG0800@2|Bacteria,1RD0T@1224|Proteobacteria,2VKJG@28216|Betaproteobacteria,4ADTS@80864|Comamonadaceae 28216|Betaproteobacteria G KDPG and KHG aldolase dgoA - 4.1.2.21 ko:K01631 ko00052,ko01100,map00052,map01100 M00552 R01064 RC00307,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_28731_2 614083.AWQR01000009_gene532 7.46e-31 117.0 COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2VH7M@28216|Betaproteobacteria,4ABYZ@80864|Comamonadaceae 28216|Betaproteobacteria G 2-keto-3-deoxy-galactonokinase dgoK - 2.7.1.58 ko:K00883 ko00052,ko01100,map00052,map01100 M00552 R03387 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - DGOK k59_742238_1 375286.mma_2774 3.61e-18 76.3 2EC6V@1|root,3365B@2|Bacteria,1NBN4@1224|Proteobacteria,2VXI4@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_742238_2 375286.mma_2773 5.21e-86 254.0 28PXE@1|root,2ZCHE@2|Bacteria,1RBH2@1224|Proteobacteria,2VR1B@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_287762_1 1000565.METUNv1_03542 1.13e-252 705.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,2KUBD@206389|Rhodocyclales 206389|Rhodocyclales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_679814_2 1000565.METUNv1_01510 7.27e-107 319.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VKIS@28216|Betaproteobacteria,2KVRE@206389|Rhodocyclales 206389|Rhodocyclales S FAD-dependent pyridine - - - - - - - - - - - - Pyr_redox_2 k59_181200_1 1245471.PCA10_16400 1.14e-71 228.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RM8E@1236|Gammaproteobacteria,1YHBJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_537057_1 1122604.JONR01000011_gene3611 2.71e-10 58.9 2CU97@1|root,32SUV@2|Bacteria,1Q8X5@1224|Proteobacteria,1SBUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_537057_2 1120968.AUBX01000001_gene2221 2.31e-26 100.0 COG0599@1|root,COG0599@2|Bacteria,4NWZP@976|Bacteroidetes,47UWD@768503|Cytophagia 976|Bacteroidetes S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_144628_1 935839.JAGJ01000001_gene1246 2.8e-12 67.8 COG1802@1|root,COG1802@2|Bacteria,2I8SM@201174|Actinobacteria 201174|Actinobacteria K gntR family - - - - - - - - - - - - FCD,GntR k59_359245_1 153948.NAL212_0962 8.99e-06 49.7 COG2304@1|root,COG2304@2|Bacteria,1PE8B@1224|Proteobacteria,2WC99@28216|Betaproteobacteria,374H0@32003|Nitrosomonadales 28216|Betaproteobacteria S C-type lectin (CTL) or carbohydrate-recognition domain (CRD) - - - - - - - - - - - - VPEP k59_359245_2 522306.CAP2UW1_2627 6.23e-22 93.6 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VINV@28216|Betaproteobacteria 28216|Betaproteobacteria C Radical SAM pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_108917_1 1000565.METUNv1_00368 6.18e-80 246.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,2KV3J@206389|Rhodocyclales 206389|Rhodocyclales F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1037293_1 1000565.METUNv1_02520 9.27e-220 632.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KVNP@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1037293_2 1000565.METUNv1_02521 2.27e-51 175.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,2KXTE@206389|Rhodocyclales 206389|Rhodocyclales C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S k59_359250_2 631362.Thi970DRAFT_03376 2.45e-51 164.0 COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,1S4IJ@1236|Gammaproteobacteria,1WZ8K@135613|Chromatiales 135613|Chromatiales K transcription regulator containing HTH domain - - - - - - - - - - - - - k59_181225_1 1000565.METUNv1_02961 3.81e-233 659.0 COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,2KV3G@206389|Rhodocyclales 206389|Rhodocyclales E COG1982 Arginine lysine ornithine decarboxylases adiA - 4.1.1.19 ko:K01584 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N k59_1073747_1 1168059.KB899087_gene3099 9.49e-72 241.0 COG1807@1|root,COG1807@2|Bacteria,1NSSV@1224|Proteobacteria,2TSZG@28211|Alphaproteobacteria,3EZ8R@335928|Xanthobacteraceae 28211|Alphaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_1073747_2 1000565.METUNv1_02049 1.66e-42 152.0 COG0598@1|root,COG0598@2|Bacteria,1R7FC@1224|Proteobacteria,2VKBA@28216|Betaproteobacteria,2KUWR@206389|Rhodocyclales 206389|Rhodocyclales P Magnesium transport protein CorA - - - - - - - - - - - - CorA k59_502673_1 1000565.METUNv1_01901 1.4e-130 380.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2VIY7@28216|Betaproteobacteria,2KW97@206389|Rhodocyclales 206389|Rhodocyclales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_359269_1 1000565.METUNv1_01864 3.64e-192 545.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,2KU7B@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_324139_1 1000565.METUNv1_01441 5.19e-107 318.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VP45@28216|Betaproteobacteria,2KY6W@206389|Rhodocyclales 206389|Rhodocyclales EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - - - - - - - - - - - - k59_182254_3 1449350.OCH239_12595 3.24e-08 53.5 2E5FX@1|root,3307M@2|Bacteria,1N8E5@1224|Proteobacteria,2UAZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_788470_1 1276756.AUEX01000005_gene2681 8.4e-46 155.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,4AA97@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM Thioredoxin domain - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_1038168_1 1000565.METUNv1_02295 2.41e-111 335.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,2KU69@206389|Rhodocyclales 206389|Rhodocyclales C Sulfite reductase cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_608753_1 1000565.METUNv1_01286 1.31e-72 222.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,2KW1V@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_608753_2 1000565.METUNv1_01283 4.46e-70 223.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2WGQX@28216|Betaproteobacteria,2KZWD@206389|Rhodocyclales 206389|Rhodocyclales E ATPases associated with a variety of cellular activities - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran k59_1001894_2 1000565.METUNv1_00195 3.76e-147 420.0 2CY73@1|root,32T3N@2|Bacteria,1N4WY@1224|Proteobacteria,2VVNI@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_1001894_4 1217718.ALOU01000053_gene3435 1.29e-06 48.9 COG4549@1|root,COG4549@2|Bacteria,1NC7K@1224|Proteobacteria,2VVBX@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unkown function (DUF1775) - - - ko:K09796 - - - - ko00000,ko03110 - - - DUF1775 k59_1038175_1 1000565.METUNv1_01337 5.01e-172 486.0 COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria,2VHJ0@28216|Betaproteobacteria,2KV72@206389|Rhodocyclales 206389|Rhodocyclales E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_1038175_2 1000565.METUNv1_01237 1.4e-07 52.0 28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,2KVDQ@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2863) - - - - - - - - - - - - DUF2863 k59_145306_1 1123296.JQKE01000066_gene46 1.27e-06 55.8 COG0484@1|root,COG0484@2|Bacteria,1N16C@1224|Proteobacteria,2VTZA@28216|Betaproteobacteria,2KQK4@206351|Neisseriales 206351|Neisseriales O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_680526_1 1000565.METUNv1_01943 1.21e-79 257.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales 206389|Rhodocyclales U Type 4 fimbrial biogenesis protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_503723_1 391735.Veis_0237 0.000534 42.0 COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,4AJ1A@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_503723_2 399795.CtesDRAFT_PD2309 3.62e-83 260.0 COG3181@1|root,COG3181@2|Bacteria,1MYJX@1224|Proteobacteria,2VKS4@28216|Betaproteobacteria,4AA33@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM conserved - - - - - - - - - - - - TctC k59_252961_1 49964.Q94MS1_9CAUD 1.87e-31 120.0 4QB4H@10239|Viruses,4QYQI@35237|dsDNA viruses no RNA stage,4QUAR@28883|Caudovirales,4QNUV@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_252961_2 375286.mma_2203 4.04e-34 135.0 2E5FK@1|root,3307A@2|Bacteria,1N95D@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_252961_5 156889.Mmc1_1012 1.5e-131 410.0 COG2268@1|root,COG2268@2|Bacteria,1NT13@1224|Proteobacteria,2U335@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Band 7 protein - - - - - - - - - - - - - k59_252961_7 398578.Daci_1942 9.71e-120 364.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2VN61@28216|Betaproteobacteria,4AIY5@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_858968_1 1452718.JBOY01000039_gene2294 5.99e-20 83.6 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_5014 PRA-CH,PRA-PH k59_858968_2 935567.JAES01000005_gene501 4.12e-24 95.1 COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,1S7UR@1236|Gammaproteobacteria,1X6P3@135614|Xanthomonadales 135614|Xanthomonadales S Putative member of DMT superfamily (DUF486) - - - ko:K09922 - - - - ko00000 - - - DMT_6 k59_395800_1 640081.Dsui_1958 8.56e-188 538.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,2KU9R@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_252963_1 1123248.KB893338_gene2310 2.77e-110 321.0 COG1136@1|root,COG1136@2|Bacteria,4NEC5@976|Bacteroidetes,1IQ7K@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter - - - - - - - - - - - - ABC_tran k59_895364_1 1000565.METUNv1_02296 9.2e-40 138.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2VMUD@28216|Betaproteobacteria,2KVNG@206389|Rhodocyclales 206389|Rhodocyclales S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_895364_2 1000565.METUNv1_02297 1.7e-191 535.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,2KURX@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_895364_3 1000565.METUNv1_02298 7.3e-53 174.0 COG3211@1|root,COG3211@2|Bacteria 2|Bacteria O Phosphatase - - - - - - - - - - - - DUF839 k59_895364_4 1000565.METUNv1_02299 7.58e-29 115.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VPB3@28216|Betaproteobacteria,2KVVY@206389|Rhodocyclales 206389|Rhodocyclales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_4,TPR_8 k59_1001910_1 1000565.METUNv1_03566 1.89e-142 406.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,2KV6V@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_1001910_2 1000565.METUNv1_03567 1.34e-14 71.6 COG0583@1|root,COG0583@2|Bacteria,1MXDQ@1224|Proteobacteria,2VHNE@28216|Betaproteobacteria,2KY7Q@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1074890_1 1000565.METUNv1_01534 2.65e-132 387.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,2KVWT@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,HDOD k59_1074890_2 1031711.RSPO_c02678 7.84e-15 73.6 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1K10P@119060|Burkholderiaceae 28216|Betaproteobacteria G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II algC GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_573388_1 748247.AZKH_0320 3.32e-11 64.7 COG3292@1|root,COG3292@2|Bacteria,1QU1S@1224|Proteobacteria,2VPDV@28216|Betaproteobacteria 28216|Betaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_573388_2 197221.22296157 1.37e-06 50.8 COG2010@1|root,COG2010@2|Bacteria,1G7SH@1117|Cyanobacteria 1117|Cyanobacteria C 'Cytochrome c cytM - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_930215_1 1249480.B649_01535 4.72e-32 126.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_9 k59_466864_1 1000565.METUNv1_01184 2.41e-57 189.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,2KU64@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_466864_2 1000565.METUNv1_01183 1.62e-46 157.0 COG4520@1|root,COG4520@2|Bacteria,1RIHU@1224|Proteobacteria,2VTAT@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycine zipper - - - - - - - - - - - - 17kDa_Anti_2,Rick_17kDa_Anti k59_466864_3 1000565.METUNv1_01182 3.61e-115 337.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,2KUYX@206389|Rhodocyclales 206389|Rhodocyclales L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_466864_4 305700.B447_05413 6.31e-41 141.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2VUIW@28216|Betaproteobacteria,2KWTR@206389|Rhodocyclales 206389|Rhodocyclales K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_466864_5 1000565.METUNv1_01180 2.4e-92 278.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2VQR7@28216|Betaproteobacteria,2KWUU@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase M22 glycoprotease - - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_466864_6 1000565.METUNv1_01179 8.01e-08 52.4 COG2204@1|root,COG2204@2|Bacteria,1QVPI@1224|Proteobacteria,2WHXV@28216|Betaproteobacteria 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg,TPR_16 k59_1074898_1 1500894.JQNN01000001_gene2205 1.26e-23 100.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,4732M@75682|Oxalobacteraceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_1074898_2 640081.Dsui_3138 1.03e-91 281.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,2KVNI@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_823562_2 1120977.JHUX01000003_gene1395 3.26e-23 99.4 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1SASH@1236|Gammaproteobacteria,3NJ8R@468|Moraxellaceae 1236|Gammaproteobacteria U Type II secretion system (T2SS), protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_788518_1 543728.Vapar_2101 4.06e-90 275.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,4A9YH@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_537775_1 1000565.METUNv1_00376 4.12e-199 581.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales 206389|Rhodocyclales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_646543_1 1000565.METUNv1_03884 2.05e-113 330.0 2C1VZ@1|root,32R98@2|Bacteria,1RJ8X@1224|Proteobacteria,2VRVA@28216|Betaproteobacteria,2KWXN@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_646543_2 1000565.METUNv1_03885 7.81e-155 445.0 COG0265@1|root,COG0265@2|Bacteria,1RG0B@1224|Proteobacteria,2WFG8@28216|Betaproteobacteria 28216|Betaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_717075_1 1000565.METUNv1_01275 4.61e-114 342.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,2KUP1@206389|Rhodocyclales 206389|Rhodocyclales O Alkyl hydroperoxide reductase - - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_1108974_1 1124780.ANNU01000005_gene2355 3.28e-18 83.2 COG0157@1|root,COG0157@2|Bacteria,4NDXF@976|Bacteroidetes,47JJ8@768503|Cytophagia 976|Bacteroidetes H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_1108974_3 929703.KE386491_gene3580 3.94e-77 254.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,47JV4@768503|Cytophagia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_573408_1 1000565.METUNv1_02898 6.34e-146 417.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,2KVU7@206389|Rhodocyclales 206389|Rhodocyclales NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_573408_2 1000565.METUNv1_02897 3e-79 246.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KUZY@206389|Rhodocyclales 206389|Rhodocyclales U type II secretion system protein pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_395855_2 85643.Tmz1t_2911 6.1e-38 129.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,2KX39@206389|Rhodocyclales 206389|Rhodocyclales N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_432262_1 402626.Rpic_4646 5.86e-122 356.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,1K5RY@119060|Burkholderiaceae 28216|Betaproteobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1001946_1 1051646.VITU9109_12987 8.9e-16 76.6 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XTBX@135623|Vibrionales 135623|Vibrionales M ADP-heptose--LPS heptosyltransferase II rfaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1001946_2 1268622.AVS7_01583 3.66e-23 95.5 COG3631@1|root,COG3631@2|Bacteria,1QXIX@1224|Proteobacteria,2WH4R@28216|Betaproteobacteria,4AJV6@80864|Comamonadaceae 28216|Betaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_717088_1 1000565.METUNv1_02116 6.97e-210 584.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KUVS@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_966141_1 765913.ThidrDRAFT_3298 7.47e-163 525.0 COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WXVG@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_938329_1 1122951.ATUE01000005_gene1575 5.7e-80 250.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,3NK2Y@468|Moraxellaceae 1236|Gammaproteobacteria CP Rieske-like [2Fe-2S] domain nirB - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2 k59_223390_1 1000565.METUNv1_02507 9.66e-159 476.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KV93@206389|Rhodocyclales 206389|Rhodocyclales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_938333_1 232721.Ajs_0736 5.27e-23 97.4 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,4AB16@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_938333_2 887062.HGR_06381 1.28e-40 149.0 COG2807@1|root,COG2807@2|Bacteria,1QU85@1224|Proteobacteria,2VNPC@28216|Betaproteobacteria,4AC7D@80864|Comamonadaceae 28216|Betaproteobacteria P Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_404843_1 1000565.METUNv1_03496 3.44e-154 439.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,2KW06@206389|Rhodocyclales 206389|Rhodocyclales O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_938351_1 614083.AWQR01000004_gene836 2.31e-62 204.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,4AA39@80864|Comamonadaceae 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_938351_2 887062.HGR_03247 2.1e-12 66.6 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,4ABQS@80864|Comamonadaceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_868612_1 1223521.BBJX01000001_gene1027 6.99e-41 145.0 2DD05@1|root,2ZG0C@2|Bacteria,1RC2B@1224|Proteobacteria,2VQ0R@28216|Betaproteobacteria,4ADF9@80864|Comamonadaceae 28216|Betaproteobacteria S Sporulation domain protein - - - - - - - - - - - - - k59_155107_1 1121033.AUCF01000001_gene1998 4.73e-56 197.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,Response_reg k59_938359_1 1268622.AVS7_02014 2.23e-08 51.6 COG3198@1|root,COG3198@2|Bacteria,1N8D0@1224|Proteobacteria,2VWBW@28216|Betaproteobacteria,4AFBX@80864|Comamonadaceae 28216|Betaproteobacteria S FixH - - - ko:K09926 - - - - ko00000 - - - FixH k59_938359_2 1268622.AVS7_02015 3.06e-49 171.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,4AB30@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_404858_2 1123248.KB893315_gene3156 1.54e-43 147.0 COG0740@1|root,COG0740@2|Bacteria,4NE20@976|Bacteroidetes,1IPWN@117747|Sphingobacteriia 976|Bacteroidetes OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_200600_1 1000565.METUNv1_04004 9.98e-27 106.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,2KUSX@206389|Rhodocyclales 206389|Rhodocyclales C FAD binding glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_200600_2 1000565.METUNv1_04003 3.11e-101 306.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales 206389|Rhodocyclales C Glycolate oxidase subunit GlcD glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_975864_1 1458275.AZ34_07855 6.29e-78 252.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,4A9M9@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_690513_2 265072.Mfla_1147 8.88e-36 128.0 COG1525@1|root,COG1525@2|Bacteria,1PRMF@1224|Proteobacteria,2VX3N@28216|Betaproteobacteria,2KP7K@206350|Nitrosomonadales 206350|Nitrosomonadales L Staphylococcal nuclease homologues - - - - - - - - - - - - SNase k59_156774_1 261292.Nit79A3_0244 3.17e-12 64.7 COG3657@1|root,COG3657@2|Bacteria,1N74C@1224|Proteobacteria,2VVRD@28216|Betaproteobacteria,374CJ@32003|Nitrosomonadales 28216|Betaproteobacteria S TIGRFAM Addiction module killer protein, HI1419 - - - - - - - - - - - - Gp49 k59_156774_2 1504822.CCNO01000014_gene1323 3.13e-08 53.1 COG3636@1|root,COG3636@2|Bacteria,2NS2M@2323|unclassified Bacteria 2|Bacteria K Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - HTH_3 k59_264855_1 1237149.C900_00062 1.64e-35 138.0 COG1131@1|root,COG1131@2|Bacteria,4NHPD@976|Bacteroidetes,47KQD@768503|Cytophagia 976|Bacteroidetes V ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane,ABC_tran,TerB k59_975870_1 1331660.L313_1907 2.92e-33 125.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,3NJ3M@468|Moraxellaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_975870_2 347834.RHE_CH03987 7.57e-10 58.2 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2U9BA@28211|Alphaproteobacteria,4BDR3@82115|Rhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1993) - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_156775_1 1000565.METUNv1_01190 3.62e-140 407.0 COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2VIAD@28216|Betaproteobacteria,2KV33@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_870327_1 1349767.GJA_297 3.77e-05 44.7 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,4735X@75682|Oxalobacteraceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_870327_2 1198452.Jab_2c33510 2.52e-56 178.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,474V1@75682|Oxalobacteraceae 28216|Betaproteobacteria U Preprotein translocase subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_522070_1 1000565.METUNv1_02536 2.98e-192 536.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KUZH@206389|Rhodocyclales 206389|Rhodocyclales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_522070_2 1000565.METUNv1_02537 1.6e-27 110.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,2KUC2@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1118596_1 925409.KI911562_gene1083 2.77e-91 296.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1J0P3@117747|Sphingobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - GO:0001871,GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009987,GO:0010467,GO:0016020,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030246,GO:0030247,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:2001070 - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_343288_2 1163409.UUA_03628 4.77e-42 142.0 COG0697@1|root,COG0697@2|Bacteria,1RHK2@1224|Proteobacteria,1S925@1236|Gammaproteobacteria,1X7B2@135614|Xanthomonadales 135614|Xanthomonadales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_522081_1 517417.Cpar_1037 6.08e-10 55.5 2E3QA@1|root,32YN8@2|Bacteria,1FFJG@1090|Chlorobi 1090|Chlorobi M Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_522081_2 1198452.Jab_1c05910 5.46e-42 150.0 COG2831@1|root,COG2831@2|Bacteria,1QW38@1224|Proteobacteria,2VVSB@28216|Betaproteobacteria 28216|Betaproteobacteria U Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_343307_1 392500.Swoo_1419 9.26e-70 221.0 COG0834@1|root,COG0834@2|Bacteria,1RCP2@1224|Proteobacteria,1S2BF@1236|Gammaproteobacteria,2QD8E@267890|Shewanellaceae 1236|Gammaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_761322_1 289376.THEYE_A0777 9.71e-09 64.3 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,3J0XC@40117|Nitrospirae 40117|Nitrospirae T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1118615_1 1476583.DEIPH_ctg025orf0210 4.33e-67 209.0 COG0225@1|root,COG0225@2|Bacteria,1WK2Z@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_50165_1 1101195.Meth11DRAFT_0193 1.88e-179 506.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2VK8Q@28216|Betaproteobacteria,2KNH4@206350|Nitrosomonadales 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_727577_1 1000565.METUNv1_01301 5.81e-52 171.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,2KUH5@206389|Rhodocyclales 206389|Rhodocyclales J Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_727577_2 1000565.METUNv1_01302 3.95e-165 488.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KV4M@206389|Rhodocyclales 206389|Rhodocyclales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_156825_1 1123368.AUIS01000026_gene1434 1.58e-33 126.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,1RQKM@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Band 7 protein - - - - - - - - - - - - Band_7 k59_1118626_1 318161.Sden_1683 2.76e-47 174.0 COG0642@1|root,COG2202@1|root,COG3614@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QACP@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg,dCache_1 k59_548461_1 338969.Rfer_2324 3.95e-109 323.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VIN1@28216|Betaproteobacteria,4AAWT@80864|Comamonadaceae 28216|Betaproteobacteria ET extracellular solute-binding protein, family 3 aapJ - - ko:K02030,ko:K09969,ko:K10001 ko02010,ko02020,map02010,map02020 M00230,M00232,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_13816_1 339671.Asuc_1210 2.22e-29 117.0 COG0417@1|root,COG0417@2|Bacteria,1QVMG@1224|Proteobacteria,1T2EP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Predicted 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_870376_1 1504672.669787082 6.25e-35 120.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VSQE@28216|Betaproteobacteria,4AE6C@80864|Comamonadaceae 28216|Betaproteobacteria C Ferredoxin, 2Fe-2S type, ISC system fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_870376_2 543728.Vapar_2146 1.61e-26 109.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,4A9TW@80864|Comamonadaceae 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_200709_2 1205753.A989_18603 4.48e-26 105.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1X52C@135614|Xanthomonadales 135614|Xanthomonadales T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_120544_1 1122951.ATUE01000007_gene626 1.7e-79 254.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,3NIG0@468|Moraxellaceae 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 ABC_membrane,ABC_tran k59_800686_4 754331.AEME01000001_gene3601 7.9e-12 65.1 2EKFR@1|root,33E5V@2|Bacteria,1QR5F@1224|Proteobacteria,1RTZX@1236|Gammaproteobacteria,3XQ6A@561|Escherichia 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_939721_1 236097.ADG881_2760 3.55e-77 251.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1XIWM@135619|Oceanospirillales 135619|Oceanospirillales L DNA helicase recQ1 - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_835599_2 1235457.C404_07240 2.76e-13 68.9 COG0583@1|root,COG0583@2|Bacteria,1R5BA@1224|Proteobacteria,2VPVZ@28216|Betaproteobacteria,1KCX9@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - ko:K10918 ko05111,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_451235_1 1120977.JHUX01000005_gene2786 3.5e-54 180.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,3NK2X@468|Moraxellaceae 1236|Gammaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family speC - 4.1.1.17,4.1.1.20 ko:K01581,ko:K01586 ko00300,ko00330,ko00480,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map00480,map01100,map01110,map01120,map01130,map01230 M00016,M00134,M00525,M00526,M00527 R00451,R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0864 Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_451235_2 448385.sce5468 4.67e-29 117.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_761361_1 288000.BBta_5301 3.56e-44 160.0 COG3509@1|root,COG3509@2|Bacteria,1QW8F@1224|Proteobacteria,2TWSR@28211|Alphaproteobacteria,3JWT6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_522195_1 1216976.AX27061_3989 4.46e-27 107.0 COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,2VHTM@28216|Betaproteobacteria,3T6GR@506|Alcaligenaceae 28216|Betaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_522195_2 296591.Bpro_4513 5.79e-36 131.0 COG3181@1|root,COG3181@2|Bacteria,1R8A2@1224|Proteobacteria,2WEW1@28216|Betaproteobacteria,4AB3R@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1090217_1 1000565.METUNv1_02753 1.39e-178 501.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,2VIUT@28216|Betaproteobacteria,2KUKV@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_939738_1 1000565.METUNv1_01315 1.44e-53 176.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,2KYRE@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_939738_2 1000565.METUNv1_01316 3.3e-65 209.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,2KVDP@206389|Rhodocyclales 206389|Rhodocyclales E PFAM Aminotransferase class I and II dapC - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_406205_1 639282.DEFDS_2108 3.68e-27 108.0 COG0457@1|root,COG0457@2|Bacteria,2GFCR@200930|Deferribacteres 200930|Deferribacteres S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_582472_2 649747.HMPREF0083_05002 2.7e-10 63.2 COG1309@1|root,COG1309@2|Bacteria,1TSFG@1239|Firmicutes,4HQ9E@91061|Bacilli,2706W@186822|Paenibacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_343461_2 1198452.Jab_1c06430 3.27e-22 95.9 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VNE4@28216|Betaproteobacteria,47630@75682|Oxalobacteraceae 28216|Betaproteobacteria E Rhodanese Homology Domain nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5,Rhodanese k59_548557_1 1485545.JQLW01000010_gene1615 4.8e-13 75.1 COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3 k59_800754_1 93220.LV28_01115 1.84e-76 237.0 COG0583@1|root,COG0583@2|Bacteria,1MVJ7@1224|Proteobacteria,2VHIJ@28216|Betaproteobacteria,1K103@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_451325_1 296591.Bpro_2052 6.05e-122 364.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,4AACA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_906781_1 358220.C380_09830 1.77e-29 124.0 COG0419@1|root,COG1196@1|root,COG4913@1|root,COG0419@2|Bacteria,COG1196@2|Bacteria,COG4913@2|Bacteria,1MU81@1224|Proteobacteria,2VNT4@28216|Betaproteobacteria,4ADWX@80864|Comamonadaceae 28216|Betaproteobacteria D Prophage tail length tape measure - - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_120630_1 1122164.JHWF01000011_gene2485 2.5e-30 115.0 COG1670@1|root,COG1670@2|Bacteria,1N9TX@1224|Proteobacteria 1224|Proteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_761402_1 748247.AZKH_3596 1.65e-30 115.0 COG1216@1|root,COG1216@2|Bacteria,1RKB9@1224|Proteobacteria,2VNSY@28216|Betaproteobacteria,2KWNH@206389|Rhodocyclales 206389|Rhodocyclales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_761402_2 1268239.PALB_28970 2.09e-08 62.4 COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,1T1TU@1236|Gammaproteobacteria,2Q1U7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_478626_1 748247.AZKH_4103 2.88e-06 46.6 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,2VX71@28216|Betaproteobacteria 28216|Betaproteobacteria S May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_478626_2 1538295.JY96_18500 7.23e-61 196.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,1KK2Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria E serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_727667_1 1198452.Jab_2c28910 1.5e-159 456.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,472TI@75682|Oxalobacteraceae 28216|Betaproteobacteria I PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1050134_1 375286.mma_2736 3.51e-11 62.4 COG0790@1|root,COG0790@2|Bacteria,1PV7Z@1224|Proteobacteria,2WB58@28216|Betaproteobacteria,476BJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - - - - - - - - - - - k59_920961_1 543728.Vapar_0263 1.39e-111 334.0 COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2WGIZ@28216|Betaproteobacteria,4A9M2@80864|Comamonadaceae 28216|Betaproteobacteria G Major facilitator superfamily ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_920961_2 358220.C380_01560 3.19e-27 108.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,4ABX0@80864|Comamonadaceae 28216|Betaproteobacteria O peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48 k59_238547_1 1000565.METUNv1_03425 3.07e-98 314.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY9@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_136781_1 929713.NIASO_08090 8.12e-10 60.5 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IV3D@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_136781_2 929713.NIASO_08095 4.16e-18 85.5 COG2335@1|root,COG2335@2|Bacteria,4NI6Z@976|Bacteroidetes,1IQ5T@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function - - - - - - - - - - - - DUF4993,Fasciclin k59_853800_1 614083.AWQR01000005_gene1056 9e-52 170.0 COG1639@1|root,COG1639@2|Bacteria,1NQD3@1224|Proteobacteria,2VPTF@28216|Betaproteobacteria,4ABWF@80864|Comamonadaceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_853800_2 338969.Rfer_1985 8.26e-43 147.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,2VNBH@28216|Betaproteobacteria,4ABCP@80864|Comamonadaceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_420612_1 984262.SGRA_0396 3.74e-80 254.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1IPPK@117747|Sphingobacteriia 976|Bacteroidetes M membrane protein involved in D-alanine export - - - ko:K19294 - - - - ko00000 - - - MBOAT k59_1031222_1 1000565.METUNv1_02433 3.35e-130 370.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,2KV7E@206389|Rhodocyclales 206389|Rhodocyclales E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_743253_1 1198452.Jab_2c28800 2.16e-114 332.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,473WN@75682|Oxalobacteraceae 28216|Betaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_991692_1 929556.Solca_3293 8.46e-35 131.0 COG0056@1|root,COG0056@2|Bacteria,4NFZW@976|Bacteroidetes,1IP4E@117747|Sphingobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_991692_2 755732.Fluta_1156 2.39e-32 120.0 COG0224@1|root,COG0224@2|Bacteria,4NECM@976|Bacteroidetes,1HX6V@117743|Flavobacteriia,2PABW@246874|Cryomorphaceae 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_420647_1 700598.Niako_3021 1.06e-35 140.0 COG3291@1|root,COG3291@2|Bacteria,4NRDH@976|Bacteroidetes,1IWXM@117747|Sphingobacteriia 976|Bacteroidetes M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - CHU_C,PKD k59_29544_2 1144319.PMI16_00955 8e-06 45.1 2BQ8N@1|root,32J3G@2|Bacteria,1PXCV@1224|Proteobacteria,2WCU2@28216|Betaproteobacteria,4787I@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_29544_3 388051.AUFE01000006_gene1227 3.95e-18 82.4 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,1K0ZE@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_321153_1 1000565.METUNv1_02917 8.45e-87 268.0 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,2KVTK@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_953077_1 365044.Pnap_0484 4.55e-44 145.0 COG3162@1|root,COG3162@2|Bacteria,1MZF3@1224|Proteobacteria,2VTZZ@28216|Betaproteobacteria,4AEQT@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function, DUF485 - - - - - - - - - - - - DUF485 k59_953077_2 987059.RBXJA2T_03071 3.89e-24 101.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VHP4@28216|Betaproteobacteria,1KJE8@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_815522_1 1458357.BG58_08895 1.43e-87 262.0 COG0693@1|root,COG0693@2|Bacteria,1MYS4@1224|Proteobacteria,2VHFV@28216|Betaproteobacteria,1K4UB@119060|Burkholderiaceae 28216|Betaproteobacteria S DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_420654_1 1000565.METUNv1_02455 1.53e-168 472.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,2KUER@206389|Rhodocyclales 206389|Rhodocyclales S cAMP phosphodiesterases class-II - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_420654_2 1000565.METUNv1_02454 8.66e-204 584.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales 206389|Rhodocyclales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1100588_2 1121033.AUCF01000013_gene1651 2.19e-70 218.0 COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2TUAC@28211|Alphaproteobacteria,2JRMU@204441|Rhodospirillales 204441|Rhodospirillales C COG4237 Hydrogenase 4 membrane component (E) hyfE - - ko:K12140 - - - - ko00000,ko01000 - - - - k59_743313_1 1094489.BAnh1_10940 4.29e-82 256.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,48TSD@772|Bartonellaceae 28211|Alphaproteobacteria S Phage terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_953094_1 1504672.669784995 1.69e-80 256.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VK3H@28216|Betaproteobacteria,4ACYH@80864|Comamonadaceae 28216|Betaproteobacteria J PFAM Amidase atzF - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - Amidase k59_321186_1 1458357.BG58_40780 8.57e-83 246.0 COG1522@1|root,COG1522@2|Bacteria,1RI47@1224|Proteobacteria,2VT2Z@28216|Betaproteobacteria,1K7G5@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_65873_1 1123392.AQWL01000019_gene34 4.62e-97 306.0 COG1061@1|root,COG1061@2|Bacteria,1MWY3@1224|Proteobacteria,2VPZ6@28216|Betaproteobacteria 28216|Betaproteobacteria KL Type III restriction enzyme, res subunit - - - - - - - - - - - - ResIII k59_596190_1 234621.RER_01730 5.05e-07 53.9 COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4FWB0@85025|Nocardiaceae 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_321188_2 1000565.METUNv1_01012 0.0 945.0 COG0365@1|root,COG0365@2|Bacteria,1MXDK@1224|Proteobacteria,2VIAE@28216|Betaproteobacteria,2KVNN@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_775179_1 1307437.J139_11848 0.00012 45.4 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,2PZWS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria N Belongs to the bacterial flagellin family flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_1031310_1 765911.Thivi_3433 2.73e-17 85.9 COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S0TC@1236|Gammaproteobacteria,1WWZI@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_102396_1 652103.Rpdx1_1594 1.88e-24 98.2 COG4564@1|root,COG4564@2|Bacteria,1RJP6@1224|Proteobacteria,2U95U@28211|Alphaproteobacteria,3K42K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Cache_2 - - - - - - - - - - - - sCache_2 k59_1100630_1 84531.JMTZ01000003_gene2355 9.71e-15 75.1 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RZRG@1236|Gammaproteobacteria,1X7ZU@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1100630_2 398527.Bphyt_6272 4.99e-24 98.2 COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VPIW@28216|Betaproteobacteria,1K6E5@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the glycosyltransferase 26 family tagA - 2.4.1.187 ko:K05946,ko:K13660 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB,STAS_2 k59_921080_1 93220.LV28_10280 1.17e-44 157.0 COG3781@1|root,COG3781@2|Bacteria,1MX91@1224|Proteobacteria,2VHY9@28216|Betaproteobacteria,1K2F9@119060|Burkholderiaceae 28216|Betaproteobacteria S Bestrophin, RFP-TM, chloride channel - - - ko:K08994 - - - - ko00000,ko02000 1.A.46.2 - - Bestrophin k59_853940_1 700598.Niako_6047 1.49e-54 176.0 2AFQQ@1|root,315SK@2|Bacteria,4NJD4@976|Bacteroidetes,1IZCK@117747|Sphingobacteriia 976|Bacteroidetes S NUMOD4 motif - - - - - - - - - - - - HNH_3,NUMOD4 k59_1103193_1 1047013.AQSP01000144_gene837 2.08e-23 100.0 COG2227@1|root,COG2227@2|Bacteria,2NPWI@2323|unclassified Bacteria 2|Bacteria H Methionine biosynthesis protein MetW - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_2,TPR_8 k59_423864_1 535289.Dtpsy_0923 8.79e-48 164.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,4ABTG@80864|Comamonadaceae 28216|Betaproteobacteria M Nlpbdapx family lipoprotein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_140137_1 1454007.JAUG01000045_gene3809 4.08e-76 244.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,4NFCF@976|Bacteroidetes,1IP5Y@117747|Sphingobacteriia 976|Bacteroidetes P Chloride channel - - - - - - - - - - - - CBS,Voltage_CLC k59_423865_2 1000565.METUNv1_02472 2.5e-30 115.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,2KUBZ@206389|Rhodocyclales 206389|Rhodocyclales S Permease YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_423867_1 1201288.M900_2473 1.26e-79 256.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2MSWD@213481|Bdellovibrionales,2WJ5U@28221|Deltaproteobacteria 213481|Bdellovibrionales T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_177437_1 1122951.ATUE01000009_gene390 2.43e-19 87.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,3NJ9C@468|Moraxellaceae 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_630984_3 693986.MOC_2148 6.43e-15 74.3 COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,2U97G@28211|Alphaproteobacteria,1JTFR@119045|Methylobacteriaceae 28211|Alphaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_1103207_1 1158292.JPOE01000002_gene3620 1.43e-20 89.0 COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,2VRXA@28216|Betaproteobacteria,1KMTK@119065|unclassified Burkholderiales 28216|Betaproteobacteria S DinB family - - - - - - - - - - - - DinB k59_1103207_2 522306.CAP2UW1_4420 1.22e-66 204.0 COG3324@1|root,COG3324@2|Bacteria,1N7Q5@1224|Proteobacteria,2VT7E@28216|Betaproteobacteria 28216|Betaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K06996 - - - - ko00000 - - - Glyoxalase k59_924164_1 946483.Cenrod_1530 6.76e-45 151.0 COG1776@1|root,COG1776@2|Bacteria,1R430@1224|Proteobacteria,2VS4K@28216|Betaproteobacteria,4AI8Y@80864|Comamonadaceae 28216|Betaproteobacteria NT chemotaxis protein - - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC k59_924164_2 883.DvMF_1461 2.02e-07 56.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2M91Y@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_631010_1 700598.Niako_3630 4.89e-102 306.0 COG1804@1|root,COG1804@2|Bacteria,4NJ3Y@976|Bacteroidetes,1IRN2@117747|Sphingobacteriia 976|Bacteroidetes C PFAM CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1103235_1 614083.AWQR01000038_gene1428 1.13e-29 115.0 COG0834@1|root,COG0834@2|Bacteria,1N329@1224|Proteobacteria,2VX7Q@28216|Betaproteobacteria 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_818877_1 159087.Daro_2883 2.52e-40 152.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KVH3@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_709710_1 1122951.ATUE01000007_gene780 2.01e-122 375.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,3NM3J@468|Moraxellaceae 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_631028_1 1268622.AVS7_01115 6.79e-83 256.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,4AAIV@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM aminotransferase, class I and II aspC - - - - - - - - - - - Aminotran_1_2 k59_631028_2 1442599.JAAN01000011_gene345 0.000195 42.4 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1X6W5@135614|Xanthomonadales 135614|Xanthomonadales S Acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_709721_1 365044.Pnap_3256 8.01e-89 272.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,4AA4E@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_140224_1 1000565.METUNv1_03637 6.87e-62 200.0 2DZ3T@1|root,32V6K@2|Bacteria,1N1CD@1224|Proteobacteria,2W3TW@28216|Betaproteobacteria,2KZ3D@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1138013_1 1000565.METUNv1_01482 3.47e-78 254.0 COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2VMGW@28216|Betaproteobacteria,2KUWD@206389|Rhodocyclales 206389|Rhodocyclales M Penicillin-Binding Protein C-terminus Family - - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase k59_177535_2 1000565.METUNv1_02083 1.84e-88 262.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,2KWH7@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_995019_1 232721.Ajs_4062 3.4e-19 87.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria,4AGED@80864|Comamonadaceae 28216|Betaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,NIT k59_995019_2 1454004.AW11_03331 1.4e-53 185.0 COG1226@1|root,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria 1224|Proteobacteria P Ion transport 2 domain protein - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_242195_1 1198452.Jab_1c17880 8.16e-107 337.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2WI8D@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_106210_1 323097.Nham_3613 5.18e-08 58.9 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,3JS8I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase k59_956323_1 1198452.Jab_1c06350 7.86e-105 334.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,472V5@75682|Oxalobacteraceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_69308_1 595537.Varpa_1233 2.19e-51 174.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,4AB16@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_69308_2 391038.Bphy_2733 1.04e-15 75.1 COG3310@1|root,COG3310@2|Bacteria,1RCUF@1224|Proteobacteria,2WFKP@28216|Betaproteobacteria,1KFZ8@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1415) - - - ko:K09941 - - - - ko00000 - - - DUF1415 k59_284886_1 1000565.METUNv1_03819 1.97e-126 369.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,2KVH7@206389|Rhodocyclales 206389|Rhodocyclales M Mycolic acid cyclopropane synthetase cfA - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_995069_1 614083.AWQR01000011_gene2343 3.08e-49 164.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,4AARC@80864|Comamonadaceae 28216|Betaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_995069_2 338969.Rfer_2298 1.07e-24 93.6 COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2WAPT@28216|Betaproteobacteria,4AFXA@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2065) - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_995069_3 614083.AWQR01000011_gene2345 3.01e-23 96.3 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,4A9WQ@80864|Comamonadaceae 28216|Betaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_956355_1 1000565.METUNv1_01392 1.99e-43 149.0 COG0265@1|root,COG0265@2|Bacteria,1RDHW@1224|Proteobacteria,2VRY7@28216|Betaproteobacteria,2KZ9R@206389|Rhodocyclales 28216|Betaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - TPR_2,TPR_8,Trypsin_2 k59_956355_2 1000565.METUNv1_01394 8.2e-07 50.8 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales 206389|Rhodocyclales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_423994_1 1458275.AZ34_00010 3.28e-62 200.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,4AB81@80864|Comamonadaceae 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_423994_2 887062.HGR_14329 9.97e-64 199.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,2VJ1T@28216|Betaproteobacteria,4AC78@80864|Comamonadaceae 28216|Betaproteobacteria NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_709808_2 460265.Mnod_1734 6.5e-40 141.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,1JT1V@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM aldo keto reductase - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red k59_747660_1 1000565.METUNv1_00376 1.14e-92 298.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales 206389|Rhodocyclales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_284932_1 1236902.ANAS01000001_gene1920 8.9e-50 170.0 COG2374@1|root,COG2374@2|Bacteria,2I8IB@201174|Actinobacteria,4EMT0@85012|Streptosporangiales 201174|Actinobacteria L Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Exo_endo_phos k59_709813_1 71139.XP_010032736.1 3.76e-76 252.0 COG1034@1|root,KOG2282@2759|Eukaryota,37RAU@33090|Viridiplantae,3GFDF@35493|Streptophyta 35493|Streptophyta C Belongs to the complex I 75 kDa subunit family - - 1.6.5.3,1.6.99.3 ko:K03934 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1.6 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C k59_1138120_1 999541.bgla_2g28560 1.97e-10 59.7 COG0789@1|root,COG0789@2|Bacteria,1RH2U@1224|Proteobacteria,2VSSK@28216|Betaproteobacteria,1KFPD@119060|Burkholderiaceae 28216|Betaproteobacteria K redox-sensitive transcriptional activator SoxR soxR - - ko:K13639 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_1138120_2 382245.ASA_1662 6.74e-16 78.2 2DM5B@1|root,31SEY@2|Bacteria,1RJ72@1224|Proteobacteria,1T0P4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF4243) - - - - - - - - - - - - DUF4243 k59_956403_1 1144319.PMI16_01312 5.64e-81 254.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,472Y4@75682|Oxalobacteraceae 28216|Betaproteobacteria H Flavin containing amine oxidoreductase hpnE - 1.17.8.1 ko:K21677 - - - - ko00000,ko01000 - - - Amino_oxidase k59_574753_2 203122.Sde_3513 4.57e-30 117.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,464SX@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0006 Xaa-Pro aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_539306_1 29581.BW37_04027 3.2e-78 249.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,473HI@75682|Oxalobacteraceae 28216|Betaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_506436_1 1121033.AUCF01000013_gene1575 1.49e-78 257.0 COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction histidine kinase - - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg k59_1110292_1 1007105.PT7_P058 2.62e-21 94.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2VRW1@28216|Betaproteobacteria,3T1RZ@506|Alcaligenaceae 28216|Betaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_1110292_2 557598.LHK_01773 2.65e-40 141.0 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,2VRCJ@28216|Betaproteobacteria,2KU06@206351|Neisseriales 206351|Neisseriales OU Belongs to the peptidase S14 family - - - - - - - - - - - - CLP_protease k59_327880_2 1000565.METUNv1_00368 7.9e-68 213.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,2KV3J@206389|Rhodocyclales 206389|Rhodocyclales F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_967471_1 1000565.METUNv1_03894 2.7e-153 437.0 COG1721@1|root,COG1721@2|Bacteria,1R69F@1224|Proteobacteria,2VSZ0@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_967471_2 1000565.METUNv1_03893 8.1e-68 218.0 297JP@1|root,2ZUSS@2|Bacteria,1RBY8@1224|Proteobacteria,2VQUJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - ko:K16256 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - - k59_860416_1 1121035.AUCH01000012_gene2948 1.87e-58 200.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,2KUE2@206389|Rhodocyclales 206389|Rhodocyclales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_649371_1 1000565.METUNv1_03784 3.61e-282 775.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUUN@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_649371_2 1304883.KI912532_gene2928 7.04e-31 135.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria,2KV97@206389|Rhodocyclales 206389|Rhodocyclales NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_681921_1 1198452.Jab_2c04360 5.71e-53 171.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2VJB0@28216|Betaproteobacteria,473MD@75682|Oxalobacteraceae 28216|Betaproteobacteria K Transcriptional regulatory protein, C terminal cpxR - - ko:K02483,ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_681921_2 1349767.GJA_2201 4.76e-25 103.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2WEJE@28216|Betaproteobacteria,47337@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain cpxA - 2.7.13.3 ko:K02484,ko:K07640,ko:K07642 ko01503,ko02020,map01503,map02020 M00447,M00450,M00645,M00646,M00648,M00727,M00728 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_290843_1 1000565.METUNv1_03170 1.02e-208 584.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,2KURV@206389|Rhodocyclales 206389|Rhodocyclales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_290843_2 1000565.METUNv1_03171 7.12e-07 49.7 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,2KUYH@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_506459_1 1000565.METUNv1_01663 2.53e-40 140.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,2KUS3@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rmlA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_506459_2 1000565.METUNv1_01662 7.06e-120 343.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,2VQ02@28216|Betaproteobacteria,2KUTY@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rmlC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_931589_1 1157708.KB907462_gene907 1.91e-105 311.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,4ABHP@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein baeB - - - - - - - - - - - Lactamase_B k59_1077730_1 1131553.JIBI01000006_gene1071 1.16e-10 65.1 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,372TF@32003|Nitrosomonadales 28216|Betaproteobacteria KT PFAM Metal-dependent phosphohydrolase, HD - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,GAF_2,HD k59_1077730_2 1000565.METUNv1_03494 3.25e-200 562.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KVWY@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - GAF_2,HD,HD_5 k59_1110300_1 1122951.ATUE01000013_gene1510 1.2e-103 310.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,3NKP2@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the citrate synthase family gltA GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_00727 Citrate_synt k59_753378_1 1000565.METUNv1_00325 9.7e-11 61.2 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2VI9M@28216|Betaproteobacteria,2KVMR@206389|Rhodocyclales 206389|Rhodocyclales N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_753378_2 1000565.METUNv1_00324 3.72e-149 425.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2VI19@28216|Betaproteobacteria,2KUSM@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor switch protein fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_790258_1 1187851.A33M_2755 1.91e-06 48.5 2C3ZQ@1|root,32SCF@2|Bacteria,1N27R@1224|Proteobacteria,2U7GM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MEKHLA domain protein - - - - - - - - - - - - MEKHLA k59_790258_2 1000565.METUNv1_01168 3.47e-176 499.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,2KUN7@206389|Rhodocyclales 206389|Rhodocyclales S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1110303_1 946483.Cenrod_0140 9.39e-19 85.1 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,4ABM3@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1110303_2 887062.HGR_12742 9.17e-37 127.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,4ADKA@80864|Comamonadaceae 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_468782_1 999550.KI421507_gene297 3.73e-34 127.0 COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,2TRSQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_468782_2 1158292.JPOE01000002_gene2325 2.34e-37 146.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1KKDD@119065|unclassified Burkholderiales 28216|Betaproteobacteria EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.14,6.4.1.8 ko:K01473,ko:K10701 ko00330,ko00642,ko01100,ko01120,ko01220,map00330,map00642,map01100,map01120,map01220 - R03187,R05453 RC00040,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_4332_2 1562701.BBOF01000037_gene981 3.12e-18 88.6 COG1176@1|root,COG1177@1|root,COG1176@2|Bacteria,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2VPBI@28216|Betaproteobacteria,1KFF3@119060|Burkholderiaceae 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02053,ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_290868_1 1000565.METUNv1_02670 1.24e-109 329.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KUPY@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_398057_1 864051.BurJ1DRAFT_0126 5.18e-18 79.3 COG3090@1|root,COG3090@2|Bacteria,1RFJH@1224|Proteobacteria,2VVBY@28216|Betaproteobacteria,1KNX9@119065|unclassified Burkholderiales 28216|Betaproteobacteria G PFAM Tripartite ATP-independent periplasmic - - - - - - - - - - - - DctQ k59_398057_2 864051.BurJ1DRAFT_0125 1.98e-38 137.0 COG1638@1|root,COG1638@2|Bacteria,1MWXG@1224|Proteobacteria,2WFED@28216|Betaproteobacteria,1KPKV@119065|unclassified Burkholderiales 28216|Betaproteobacteria G PFAM TRAP dicarboxylate transporter- DctP subunit - - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP k59_718567_1 572477.Alvin_2622 0.000211 43.5 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXCR@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS_9 k59_1040231_1 1000565.METUNv1_01823 2.57e-05 45.4 COG3832@1|root,COG3832@2|Bacteria,1REDB@1224|Proteobacteria,2VXCY@28216|Betaproteobacteria 28216|Betaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - ko:K16260 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - Polyketide_cyc2 k59_1040231_2 1000565.METUNv1_01825 1.58e-94 285.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VK57@28216|Betaproteobacteria,2KV84@206389|Rhodocyclales 206389|Rhodocyclales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroA - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_4336_1 640081.Dsui_0353 2.07e-115 337.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,2KVIT@206389|Rhodocyclales 206389|Rhodocyclales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_4336_2 1175306.GWL_42970 2.04e-59 184.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,474BU@75682|Oxalobacteraceae 28216|Betaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_4336_3 279714.FuraDRAFT_3621 4.74e-52 164.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,2KR9W@206351|Neisseriales 206351|Neisseriales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1110310_1 1249627.D779_3773 1.09e-136 431.0 COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_860442_1 1000565.METUNv1_00609 5.9e-168 474.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,2KUN8@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_860442_2 1000565.METUNv1_00610 3.95e-96 284.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,2KVFF@206389|Rhodocyclales 206389|Rhodocyclales S HAD-superfamily hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_254933_1 504472.Slin_0959 2.6e-10 61.2 COG2010@1|root,COG2010@2|Bacteria,4NEPV@976|Bacteroidetes,47M4N@768503|Cytophagia 976|Bacteroidetes C Protein of unknown function (DUF1549) - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_254933_2 761193.Runsl_5542 8.52e-129 378.0 COG3119@1|root,COG3119@2|Bacteria,4NGYE@976|Bacteroidetes,47MMC@768503|Cytophagia 976|Bacteroidetes P Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_435140_2 1192124.LIG30_1163 1.33e-18 84.7 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VHBK@28216|Betaproteobacteria,1K5QM@119060|Burkholderiaceae 28216|Betaproteobacteria V N-6 DNA Methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_435140_3 1335760.ASTG01000024_gene2336 1.06e-20 92.4 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2TQQA@28211|Alphaproteobacteria,2K0SV@204457|Sphingomonadales 204457|Sphingomonadales V HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_4352_1 1000565.METUNv1_01171 5.19e-90 274.0 COG0628@1|root,COG0628@2|Bacteria,1PM24@1224|Proteobacteria,2VPEN@28216|Betaproteobacteria,2KVTH@206389|Rhodocyclales 206389|Rhodocyclales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_327965_1 1000565.METUNv1_00045 2.22e-55 187.0 COG2154@1|root,COG2154@2|Bacteria,1QZYQ@1224|Proteobacteria 1224|Proteobacteria H TIR domain - - - - - - - - - - - - TIR_2 k59_1003914_1 84531.JMTZ01000082_gene1318 4.39e-75 234.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1X53J@135614|Xanthomonadales 135614|Xanthomonadales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_468828_1 1000565.METUNv1_01950 1.61e-181 514.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_435162_1 1000565.METUNv1_00455 2.27e-22 90.5 COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,2VS9E@28216|Betaproteobacteria,2KWHC@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF447) - - - ko:K09154 - - - - ko00000 - - - DUF447 k59_435162_2 1000565.METUNv1_00454 3.58e-105 319.0 COG1404@1|root,COG1404@2|Bacteria,1QY39@1224|Proteobacteria,2WH9V@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - - k59_1040265_1 243277.VC_0243 6.95e-151 431.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria,1XWBR@135623|Vibrionales 135623|Vibrionales M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008446,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_4366_1 1000565.METUNv1_02133 1.47e-177 509.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KUN3@206389|Rhodocyclales 206389|Rhodocyclales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_468832_1 1156937.MFUM_810033 5.86e-57 188.0 COG1131@1|root,COG1131@2|Bacteria,46UAZ@74201|Verrucomicrobia,37GF1@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_897559_3 667632.KB890165_gene2642 7.71e-32 125.0 28JV9@1|root,2Z9K8@2|Bacteria,1MVTX@1224|Proteobacteria,2VP25@28216|Betaproteobacteria,1K37M@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_897559_5 640510.BC1001_5874 1.66e-27 111.0 COG0433@1|root,COG0433@2|Bacteria,1N2WU@1224|Proteobacteria,2VUFK@28216|Betaproteobacteria,1K4GE@119060|Burkholderiaceae 28216|Betaproteobacteria S COG0433 Predicted ATPase - - - - - - - - - - - - - k59_650990_1 365044.Pnap_3961 1.12e-51 180.0 COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria,4AB1K@80864|Comamonadaceae 28216|Betaproteobacteria CK PFAM FMN-binding domain protein - - - ko:K19339 - - - - ko00000,ko03000 - - - FMN_bind,Fer4_10,Fer4_5 k59_399094_1 1120999.JONM01000036_gene4204 3.56e-16 72.0 2C5K0@1|root,32ZXC@2|Bacteria,1N9KG@1224|Proteobacteria,2VXCH@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_399094_3 1163409.UUA_08891 1.42e-175 506.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - RVT_1 k59_399094_5 66869.JNXG01000014_gene6973 1.59e-12 71.2 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase,SapC k59_719287_1 1353529.M899_1604 4.02e-43 149.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2MT8N@213481|Bdellovibrionales,2WM37@28221|Deltaproteobacteria 213481|Bdellovibrionales H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA - - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_682652_2 925409.KI911562_gene1172 5.91e-61 201.0 COG0696@1|root,COG0696@2|Bacteria,4NEQT@976|Bacteroidetes,1INQA@117747|Sphingobacteriia 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_255860_1 1267534.KB906760_gene1494 8.88e-23 92.4 COG4994@1|root,COG4994@2|Bacteria,3Y8HQ@57723|Acidobacteria,2JNII@204432|Acidobacteriia 204432|Acidobacteriia S Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - DUF4440 k59_186600_1 330084.JNYZ01000058_gene2992 2.84e-20 90.5 COG2267@1|root,COG2267@2|Bacteria,2HVC1@201174|Actinobacteria,4E2AR@85010|Pseudonocardiales 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1005055_2 1175306.GWL_12360 3.8e-07 51.2 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,472PS@75682|Oxalobacteraceae 28216|Betaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_147390_2 1123504.JQKD01000023_gene252 1.29e-41 145.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,4ABP2@80864|Comamonadaceae 28216|Betaproteobacteria M Lipid A biosynthesis acyltransferase htrB_2 - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_112002_1 700598.Niako_6407 2.22e-39 145.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,1IQ8E@117747|Sphingobacteriia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_436672_1 485917.Phep_1241 1.45e-78 254.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NF7I@976|Bacteroidetes,1IRKI@117747|Sphingobacteriia 976|Bacteroidetes E peptidase ptpA - 3.4.14.12,3.4.14.5 ko:K01278,ko:K18574 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_507990_1 1437824.BN940_12491 8.16e-33 122.0 COG1073@1|root,COG1073@2|Bacteria,1N03B@1224|Proteobacteria,2VV1P@28216|Betaproteobacteria,3T6X2@506|Alcaligenaceae 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_399105_1 1123376.AUIU01000016_gene253 2.73e-12 66.6 COG0451@1|root,COG0451@2|Bacteria,3J0XH@40117|Nitrospirae 40117|Nitrospirae GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_1110975_1 1221522.B723_11045 5.63e-107 326.0 COG1002@1|root,COG1002@2|Bacteria,1NZDR@1224|Proteobacteria,1RPNU@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG1002 Type II restriction enzyme, methylase subunits - - - - - - - - - - - - Eco57I,N6_Mtase k59_41723_1 296591.Bpro_3956 2.75e-29 115.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,4AAU6@80864|Comamonadaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_41723_2 296591.Bpro_3953 3.26e-48 164.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,4AAAT@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_186621_1 1198452.Jab_1c24010 9.4e-30 124.0 COG1629@1|root,COG4771@2|Bacteria,1MW4X@1224|Proteobacteria,2WC4Y@28216|Betaproteobacteria,47706@75682|Oxalobacteraceae 28216|Betaproteobacteria M Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_1110979_1 1198452.Jab_1c01150 4.26e-101 296.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,4723E@75682|Oxalobacteraceae 28216|Betaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_362956_1 614083.AWQR01000010_gene1560 8.42e-92 285.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,4ABBD@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_615467_2 1458275.AZ34_07035 1.08e-18 82.8 COG1024@1|root,COG1024@2|Bacteria,1MWYZ@1224|Proteobacteria,2VJYU@28216|Betaproteobacteria,4AB6X@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.155 ko:K20036 ko00920,map00920 - R10936 RC00004,RC03306,RC03307 ko00000,ko00001,ko01000 - - - ECH_1 k59_519700_1 1343158.SACS_0590 1.09e-75 240.0 COG3391@1|root,COG3391@2|Bacteria,1R78P@1224|Proteobacteria,2U3BG@28211|Alphaproteobacteria,2JW9N@204441|Rhodospirillales 204441|Rhodospirillales S amine dehydrogenase activity - - - - - - - - - - - - - k59_582209_1 1122152.AUEI01000004_gene835 6.84e-08 55.8 COG0847@1|root,COG0847@2|Bacteria,1V57H@1239|Firmicutes,4HI1V@91061|Bacilli,3F42Z@33958|Lactobacillaceae 91061|Bacilli L DNA polymerase III dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_582209_4 1210884.HG799462_gene9193 2.81e-53 206.0 COG0507@1|root,COG0507@2|Bacteria,2J438@203682|Planctomycetes 203682|Planctomycetes L TrwC relaxase - - - - - - - - - - - - TrwC k59_156572_1 497964.CfE428DRAFT_5438 3.18e-25 106.0 COG0657@1|root,COG0657@2|Bacteria,46U1I@74201|Verrucomicrobia 74201|Verrucomicrobia I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_665163_1 69395.JQLZ01000009_gene1939 3.2e-99 303.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2TZ9G@28211|Alphaproteobacteria,2KFJI@204458|Caulobacterales 204458|Caulobacterales C Alkyl hydroperoxide reductase ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_1013569_1 42565.FP66_11735 8.59e-56 181.0 COG1376@1|root,COG1376@2|Bacteria,1RA7Q@1224|Proteobacteria,1S5JW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD_2 k59_342956_1 56110.Oscil6304_3682 1.31e-47 174.0 COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales 1117|Cyanobacteria M Tetratricopeptide repeat - - - - - - - - - - - - DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_582227_1 614083.AWQR01000005_gene921 7.84e-109 320.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4A9QA@80864|Comamonadaceae 28216|Betaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_450811_1 755732.Fluta_0732 1.62e-22 98.2 COG0438@1|root,COG0438@2|Bacteria,4NG0D@976|Bacteroidetes,1I6W9@117743|Flavobacteriia 976|Bacteroidetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_264677_1 1175306.GWL_44600 6.54e-88 285.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,473CA@75682|Oxalobacteraceae 28216|Betaproteobacteria U MMPL family bepE_1 - - ko:K18138,ko:K18902 ko01501,ko01503,map01501,map01503 M00647,M00698,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_13604_2 479431.Namu_4907 7.17e-06 52.0 COG3291@1|root,COG3291@2|Bacteria,2GKA0@201174|Actinobacteria,4EWD2@85013|Frankiales 201174|Actinobacteria S Pregnancy-associated plasma protein-A - - - - - - - - - - - - DUF346,Peptidase_M43 k59_120290_1 614083.AWQR01000022_gene98 6.67e-19 85.1 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2VJZV@28216|Betaproteobacteria,4ABSY@80864|Comamonadaceae 28216|Betaproteobacteria F PFAM amidohydrolase dht - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_120290_2 614083.AWQR01000022_gene97 6e-78 244.0 COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,1MXER@1224|Proteobacteria,2VK6N@28216|Betaproteobacteria,4AD1V@80864|Comamonadaceae 28216|Betaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein yeiA - 1.3.1.1,1.3.1.14 ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,Fer4_21,Fer4_6 k59_870152_3 28229.ND2E_1013 2.61e-10 62.0 28M7D@1|root,2ZAKV@2|Bacteria,1R6BC@1224|Proteobacteria,1S7HU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_405981_1 159087.Daro_3267 5.06e-18 79.3 COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria,2KWE5@206389|Rhodocyclales 206389|Rhodocyclales K overlaps another CDS with the same product name nirH - - - - - - - - - - - HTH_AsnC-type k59_405981_2 305700.B447_00550 1.14e-51 167.0 COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2VSBM@28216|Betaproteobacteria,2KWF6@206389|Rhodocyclales 206389|Rhodocyclales K overlaps another CDS with the same product name nirG - - - - - - - - - - - HTH_AsnC-type k59_49981_1 1504672.669786131 1.44e-86 266.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2WGGJ@28216|Betaproteobacteria,4AAIQ@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - 2.5.1.48 ko:K01739,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1013596_1 292415.Tbd_2337 1.5e-36 143.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KRHD@119069|Hydrogenophilales 119069|Hydrogenophilales M Organic solvent tolerance protein - - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA_C k59_582247_1 288000.BBta_3144 5.46e-21 92.4 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2TQVD@28211|Alphaproteobacteria,3JUQP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H CobN/Magnesium Chelatase cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_582247_2 452662.SJA_C2-03060 9.3e-07 50.1 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TQWN@28211|Alphaproteobacteria,2K0VX@204457|Sphingomonadales 204457|Sphingomonadales S cobalamin biosynthesis protein CobW cobW - - ko:K02234 - - - - ko00000,ko00001 - - - CobW_C,cobW k59_156621_1 296591.Bpro_3285 1.03e-61 193.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,4ADG9@80864|Comamonadaceae 28216|Betaproteobacteria S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY k59_616411_1 296591.Bpro_3118 2.08e-103 315.0 COG1960@1|root,COG1960@2|Bacteria,1QMQC@1224|Proteobacteria,2VK52@28216|Betaproteobacteria,4AB8K@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_548251_1 981336.F944_00824 7.42e-43 149.0 COG0625@1|root,COG0625@2|Bacteria,1R7YC@1224|Proteobacteria,1S06X@1236|Gammaproteobacteria,3NJW3@468|Moraxellaceae 1236|Gammaproteobacteria O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 k59_120319_1 1000565.METUNv1_03215 2.98e-17 75.5 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,2VUFZ@28216|Betaproteobacteria,2KX2G@206389|Rhodocyclales 206389|Rhodocyclales S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_200393_1 700598.Niako_1479 8.75e-30 111.0 COG2085@1|root,COG2085@2|Bacteria,4NRZE@976|Bacteroidetes,1J0ES@117747|Sphingobacteriia 976|Bacteroidetes S PFAM NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_200393_2 452637.Oter_2283 4.35e-28 108.0 COG2353@1|root,COG2353@2|Bacteria,46WNH@74201|Verrucomicrobia 2|Bacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_13630_1 1276756.AUEX01000035_gene2215 1.78e-102 306.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,4AADP@80864|Comamonadaceae 28216|Betaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1013613_1 1000565.METUNv1_02693 1.08e-107 330.0 COG1181@1|root,COG1181@2|Bacteria,1QWAW@1224|Proteobacteria,2VITI@28216|Betaproteobacteria,2KVT8@206389|Rhodocyclales 206389|Rhodocyclales M Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - - - - - - - - - - - CPSase_L_D2,Mur_ligase_M,RimK k59_50010_1 421052.F945_01251 6.02e-22 95.5 COG0331@1|root,COG0331@2|Bacteria,1PPIC@1224|Proteobacteria,1SG1U@1236|Gammaproteobacteria,3NN1U@468|Moraxellaceae 1236|Gammaproteobacteria I Acyl transferase domain mdcH - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_120337_2 640081.Dsui_0792 2.09e-11 62.8 2E1J6@1|root,32WWW@2|Bacteria,1N539@1224|Proteobacteria,2VWBY@28216|Betaproteobacteria,2KYZ9@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_264722_1 1198452.Jab_1c04740 1.15e-78 244.0 COG3248@1|root,COG3248@2|Bacteria,1R7UE@1224|Proteobacteria,2VRM7@28216|Betaproteobacteria,476X6@75682|Oxalobacteraceae 28216|Betaproteobacteria M Nucleoside-binding outer membrane protein - - - - - - - - - - - - - k59_264722_2 290398.Csal_0717 3.32e-17 81.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIXB@135619|Oceanospirillales 135619|Oceanospirillales T With GlrK is part of a two-component signal transduction system regulating glmY - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_478329_1 1000565.METUNv1_00046 6.1e-70 239.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_582283_1 525244.HMPREF0023_0785 3.97e-28 108.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,3NKD9@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_582283_2 1297742.A176_04900 1.94e-25 105.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,43BBM@68525|delta/epsilon subdivisions,2X6QS@28221|Deltaproteobacteria,2Z3CB@29|Myxococcales 28221|Deltaproteobacteria EGP Acetyl-coenzyme A transporter 1 - - - - - - - - - - - - MFS_1 k59_975773_1 243365.CV_4073 1.37e-47 170.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2VGZ6@28216|Betaproteobacteria,2KPXS@206351|Neisseriales 206351|Neisseriales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,UvrD_C_2,Viral_helicase1 k59_343079_1 545695.TREAZ_1834 1.68e-18 92.8 COG0840@1|root,COG0840@2|Bacteria,2J72V@203691|Spirochaetes 203691|Spirochaetes NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_13659_1 614083.AWQR01000032_gene2904 2.52e-128 400.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,4AC3Z@80864|Comamonadaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_224710_1 1198452.Jab_2c12240 5.64e-13 64.7 COG4968@1|root,COG4968@2|Bacteria,1MZZW@1224|Proteobacteria,2VU8H@28216|Betaproteobacteria 28216|Betaproteobacteria NU Tfp pilus assembly protein - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_224710_2 1349767.GJA_2840 1.37e-52 172.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane - - - ko:K02457,ko:K02458,ko:K08084 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15,3.A.15.2 - - GspH,N_methyl k59_1049668_1 640081.Dsui_3078 2.03e-76 245.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VNJW@28216|Betaproteobacteria,2KW08@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_521900_1 573370.DMR_14660 1.36e-32 124.0 2BRKZ@1|root,32KKB@2|Bacteria,1RJ7S@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_582304_1 1000565.METUNv1_02027 9.28e-56 179.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2WGQC@28216|Betaproteobacteria,2KZX1@206389|Rhodocyclales 206389|Rhodocyclales C Oxidoreductase FAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_582304_2 1000565.METUNv1_02029 1.18e-125 367.0 COG1819@1|root,COG1819@2|Bacteria,1REWD@1224|Proteobacteria,2VR80@28216|Betaproteobacteria,2KYQU@206389|Rhodocyclales 206389|Rhodocyclales CG Glycosyl transferase family 1 - - - - - - - - - - - - - k59_1049703_1 1000565.METUNv1_01547 1.08e-76 238.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,2KUTE@206389|Rhodocyclales 206389|Rhodocyclales C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_665336_1 163908.KB235896_gene3084 7.12e-19 90.9 COG2931@1|root,COG2931@2|Bacteria,1GQPT@1117|Cyanobacteria 1117|Cyanobacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - Peptidase_S8 k59_870248_1 29581.BW37_02970 1.57e-101 298.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,473A2@75682|Oxalobacteraceae 28216|Betaproteobacteria G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_1013680_1 614083.AWQR01000028_gene3147 7.89e-39 136.0 COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2VJ7W@28216|Betaproteobacteria,4ADRM@80864|Comamonadaceae 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_1013680_2 1100720.ALKN01000034_gene554 9.7e-20 86.7 COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,4AAJG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM amidohydrolase 2 ligJ - 4.1.1.46,4.2.1.83 ko:K10220,ko:K14333 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R00821,R04478 RC00390,RC00498 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_761258_1 1177179.A11A3_00830 1.35e-91 276.0 COG0006@1|root,COG0006@2|Bacteria,1R6SF@1224|Proteobacteria,1RYAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 k59_156731_1 1217652.F954_02626 4.56e-35 136.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,3NJBH@468|Moraxellaceae 1236|Gammaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_406088_2 633131.TR2A62_1584 6.97e-06 53.1 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Sel1 domain protein repeat-containing protein - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_343186_1 159087.Daro_4112 6.93e-116 345.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,2KV0S@206389|Rhodocyclales 206389|Rhodocyclales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_85111_1 1124780.ANNU01000037_gene112 8.06e-123 362.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,4NF6I@976|Bacteroidetes,47KP9@768503|Cytophagia 976|Bacteroidetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_522000_1 1005048.CFU_2639 4.62e-49 166.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VIWR@28216|Betaproteobacteria 28216|Betaproteobacteria ET Amino acid ABC transporter substrate-binding protein - - - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_690490_1 977880.RALTA_A0966 1.08e-91 282.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VIGJ@28216|Betaproteobacteria,1K30M@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM HI0933 family protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_835512_1 1201290.M902_3177 9.66e-59 197.0 COG0755@1|root,COG0755@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2MSY8@213481|Bdellovibrionales,2WPT0@28221|Deltaproteobacteria 213481|Bdellovibrionales O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm,ResB k59_975846_1 1500894.JQNN01000001_gene733 1.03e-47 162.0 COG1073@1|root,COG1073@2|Bacteria,1RCY0@1224|Proteobacteria,2VR4Z@28216|Betaproteobacteria 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4,Peptidase_S9 k59_975846_2 1166018.FAES_3530 3.38e-50 172.0 COG3000@1|root,COG3000@2|Bacteria,4NMKR@976|Bacteroidetes,47P2V@768503|Cytophagia 976|Bacteroidetes I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_761278_1 1122951.ATUE01000007_gene560 3.96e-71 220.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,3NIW7@468|Moraxellaceae 1236|Gammaproteobacteria M Belongs to the ompA family yiaD - - ko:K12216 - - - - ko00000,ko02044 3.A.7.9.1 - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_939642_1 78245.Xaut_1337 8.19e-27 110.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2TR0H@28211|Alphaproteobacteria 28211|Alphaproteobacteria KQ GAF modulated sigma54 specific transcriptional regulator, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_451067_1 1249627.D779_1615 1.81e-30 119.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_451067_2 261292.Nit79A3_2777 0.000343 42.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2VR4C@28216|Betaproteobacteria,371P7@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_1013721_1 640081.Dsui_2535 2.03e-114 334.0 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,2KV4I@206389|Rhodocyclales 206389|Rhodocyclales P ZIP Zinc transporter - - - ko:K16267 - - - - ko00000,ko02000 2.A.5.4.11 - - Zip k59_548396_1 1000565.METUNv1_03091 1.41e-90 284.0 COG1807@1|root,COG1807@2|Bacteria,1RE4T@1224|Proteobacteria,2VQBA@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_303507_1 1392838.AWNM01000097_gene114 4.21e-140 408.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2VVGR@28216|Betaproteobacteria 28216|Betaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_407420_1 1000565.METUNv1_00871 1.4e-174 508.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,2KUS5@206389|Rhodocyclales 206389|Rhodocyclales C nitrite reductase NAD(P)H nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_524594_1 1492737.FEM08_30560 6.67e-85 273.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NT5D@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_453563_1 272568.GDI3669 2.39e-52 182.0 COG1783@1|root,COG1783@2|Bacteria,1RAGC@1224|Proteobacteria,2U6JF@28211|Alphaproteobacteria,2JSIA@204441|Rhodospirillales 204441|Rhodospirillales S phage Terminase large subunit - - - - - - - - - - - - - k59_617858_1 1198452.Jab_1c19890 4.49e-115 340.0 COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,4733J@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2 k59_951913_1 1458275.AZ34_00355 1.41e-51 163.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VTZ8@28216|Betaproteobacteria,4AFIQ@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_100746_1 649747.HMPREF0083_04954 3.04e-97 292.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26QK6@186822|Paenibacillaceae 91061|Bacilli IQ reductase - - - - - - - - - - - - adh_short_C2 k59_319829_2 1000565.METUNv1_03514 9.37e-06 47.0 COG0642@1|root,COG3614@1|root,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,2WHGB@28216|Betaproteobacteria,2KY19@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1029676_1 338969.Rfer_2173 5.19e-61 197.0 COG5495@1|root,COG5495@2|Bacteria,1RBEZ@1224|Proteobacteria,2VS2J@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF2520) - - - - - - - - - - - - DUF2520,Rossmann-like k59_1029676_2 1123504.JQKD01000002_gene3651 2.44e-13 68.6 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4ACGS@80864|Comamonadaceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_280461_1 1276756.AUEX01000014_gene2863 2.51e-100 297.0 COG0780@1|root,COG2904@1|root,COG0780@2|Bacteria,COG2904@2|Bacteria,1MW0M@1224|Proteobacteria,2VINU@28216|Betaproteobacteria,4AA88@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF,QueF_N k59_565315_1 546414.Deide_00630 1.3e-08 62.0 COG4102@1|root,COG4102@2|Bacteria,1WJA2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_951953_1 1131553.JIBI01000016_gene632 1.27e-45 162.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VMKA@28216|Betaproteobacteria,3747X@32003|Nitrosomonadales 28216|Betaproteobacteria C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_171984_1 1000565.METUNv1_02916 0.000456 46.6 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VK5J@28216|Betaproteobacteria,2KX6U@206389|Rhodocyclales 206389|Rhodocyclales F 5'-nucleotidase, C-terminal domain - - 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751,ko:K17224 ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120 M00595 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151 RC00017,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Metallophos k59_28218_1 1221522.B723_11070 3.9e-137 412.0 COG1524@1|root,COG1524@2|Bacteria,1MUYY@1224|Proteobacteria 1224|Proteobacteria S PFAM PglZ domain - - - - - - - - - - - - PglZ k59_319887_1 530564.Psta_3333 2.33e-39 146.0 COG4102@1|root,COG4102@2|Bacteria,2IX0F@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1132726_2 640081.Dsui_2742 4.14e-43 152.0 COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,2VHDP@28216|Betaproteobacteria,2KVUR@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the heat shock protein 70 family - - - ko:K04046 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_237271_1 1207076.ALAT01000147_gene273 4.08e-19 81.3 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1Z0FC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_237271_2 1504981.KO116_0364 4.59e-38 139.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1XI0U@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_392439_1 1000565.METUNv1_03583 1.4e-194 544.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,2KUCP@206389|Rhodocyclales 206389|Rhodocyclales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_496160_1 65093.PCC7418_1504 3.43e-67 218.0 COG0438@1|root,COG0438@2|Bacteria,1G13R@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_4_3,Glycos_transf_1 k59_28241_1 1215092.PA6_018_01270 8.69e-14 71.2 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1YFMR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA k59_28241_2 1121035.AUCH01000019_gene2871 1.01e-12 70.5 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,2KW1P@206389|Rhodocyclales 206389|Rhodocyclales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_741579_1 1123487.KB892845_gene369 5.61e-36 127.0 COG1595@1|root,COG1595@2|Bacteria,1PBHM@1224|Proteobacteria,2VQXD@28216|Betaproteobacteria 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_741579_2 159087.Daro_1912 2.76e-44 149.0 COG1225@1|root,COG1225@2|Bacteria,1RA5K@1224|Proteobacteria,2VP6C@28216|Betaproteobacteria 28216|Betaproteobacteria O Redoxin - - - - - - - - - - - - Redoxin k59_319916_1 1434929.X946_636 1.29e-22 96.3 COG3239@1|root,COG3239@2|Bacteria,1MXA8@1224|Proteobacteria,2W0QP@28216|Betaproteobacteria,1K3S2@119060|Burkholderiaceae 28216|Betaproteobacteria I fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_319916_2 1132836.RCCGE510_04077 1.86e-30 122.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2TS78@28211|Alphaproteobacteria,4B9XC@82115|Rhizobiaceae 28211|Alphaproteobacteria E Histidine ammonia-lyase hutH2 - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_1029788_1 614083.AWQR01000054_gene1946 8.19e-58 189.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,4AAFQ@80864|Comamonadaceae 28216|Betaproteobacteria S hydrolase of the alpha - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_1029788_2 595537.Varpa_5490 7.04e-67 206.0 COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,4AE1B@80864|Comamonadaceae 28216|Betaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_887869_1 640081.Dsui_2799 2.19e-69 229.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,2KVAJ@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_852344_1 1353529.M899_1545 7.52e-44 150.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2MT19@213481|Bdellovibrionales,2WKIR@28221|Deltaproteobacteria 213481|Bdellovibrionales J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Methyltrn_RNA_4,tRNA_m1G_MT k59_852344_2 862908.BMS_1897 5.35e-19 84.3 COG0806@1|root,COG0806@2|Bacteria,1MYUH@1224|Proteobacteria,43EVV@68525|delta/epsilon subdivisions,2MTDT@213481|Bdellovibrionales,2X23G@28221|Deltaproteobacteria 213481|Bdellovibrionales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_496214_1 614083.AWQR01000017_gene2260 1.49e-27 109.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,4ABI9@80864|Comamonadaceae 28216|Betaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_496214_2 1247726.MIM_c04820 2.08e-23 91.7 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,3T4IC@506|Alcaligenaceae 28216|Betaproteobacteria K Belongs to the BolA IbaG family yrbA - - - - - - - - - - - BolA k59_496214_3 887062.HGR_06486 7.75e-63 199.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,4AAEE@80864|Comamonadaceae 28216|Betaproteobacteria V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_741644_1 338969.Rfer_2490 1.04e-72 228.0 COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,2VJ3I@28216|Betaproteobacteria,4AB01@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase, N-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_2,GST_N_3 k59_852374_1 1479237.JMLY01000001_gene2676 1.16e-36 132.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,466EF@72275|Alteromonadaceae 1236|Gammaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_138072_2 887062.HGR_04978 7.91e-52 168.0 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2VII6@28216|Betaproteobacteria,4ABCU@80864|Comamonadaceae 28216|Betaproteobacteria I TIGRFAM 3-oxoacid CoA-transferase, B subunit scoB - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_992936_1 614083.AWQR01000035_gene3635 1.23e-87 271.0 28MN9@1|root,2ZAXV@2|Bacteria,1PPEY@1224|Proteobacteria,2W1FR@28216|Betaproteobacteria,4AH6A@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_175058_1 95619.PM1_0226545 4e-35 137.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_103862_1 1122951.ATUE01000005_gene2165 2.47e-96 299.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,3NIWY@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_1101635_1 1247649.D560_0334 3.95e-61 201.0 COG0463@1|root,COG0463@2|Bacteria,1RCGW@1224|Proteobacteria,2VTU5@28216|Betaproteobacteria,3T3CE@506|Alcaligenaceae 28216|Betaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_745075_1 580332.Slit_1403 0.000101 49.3 COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,2WGEF@28216|Betaproteobacteria,44VSA@713636|Nitrosomonadales 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - PhosphMutase k59_422032_1 296591.Bpro_3165 4.33e-69 226.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,4A9JS@80864|Comamonadaceae 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_67201_1 204773.HEAR0408 2.35e-64 212.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,472W4@75682|Oxalobacteraceae 28216|Betaproteobacteria M Ami_3 amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_629530_1 1095769.CAHF01000017_gene16 3.52e-37 137.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - ko:K03291 - - - - ko00000,ko02000 2.A.1.20 - - MFS_1 k59_629530_2 1168065.DOK_00460 1.92e-17 81.6 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,1T0QH@1236|Gammaproteobacteria,1J7GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG4257 Streptogramin lyase - - - - - - - - - - - - CarboxypepD_reg k59_499664_1 1000565.METUNv1_02652 5.35e-191 543.0 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,2VM4I@28216|Betaproteobacteria,2KW67@206389|Rhodocyclales 206389|Rhodocyclales N Belongs to the bacterial flagellin family - - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_954277_1 78245.Xaut_4480 2.73e-10 66.2 COG4675@1|root,COG4675@2|Bacteria,1PE25@1224|Proteobacteria,2V8UM@28211|Alphaproteobacteria,3F1UP@335928|Xanthobacteraceae 28211|Alphaproteobacteria S tail collar domain protein - - - - - - - - - - - - - k59_629536_1 946483.Cenrod_0841 1.93e-57 197.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria,4AB7B@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add - 3.5.4.2,3.5.4.4 ko:K01488,ko:K21053 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01244,R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_890998_1 94624.Bpet3943 0.000716 41.2 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,3T1ZZ@506|Alcaligenaceae 28216|Betaproteobacteria Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-17-dioic acid hydratase (catechol pathway) - - - ko:K18336 ko00051,ko01120,map00051,map01120 - R10691 RC00326,RC03236 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_30896_1 936053.I1CDP3 3.3e-22 105.0 COG2801@1|root,KOG0017@2759|Eukaryota,394KX@33154|Opisthokonta,3Q1Q2@4751|Fungi,1GVHD@112252|Fungi incertae sedis 4751|Fungi L transposition, RNA-mediated - - - - - - - - - - - - RVT_1,rve k59_175119_1 1123368.AUIS01000004_gene111 1.68e-48 165.0 COG0803@1|root,COG0803@2|Bacteria,1PQEX@1224|Proteobacteria,1RYA2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P periplasmic solute binding protein znuA - - ko:K02077 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ZnuA k59_855567_1 314271.RB2654_17216 2.4e-53 180.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria 28211|Alphaproteobacteria O membrane - - - - - - - - - - - - HupE_UreJ_2 k59_1135723_1 1226994.AMZB01000134_gene4591 5.64e-103 314.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1YDFM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Sulfate permease family ychM GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp k59_240040_1 396014.BF93_14650 0.000115 47.8 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4FBT4@85020|Dermabacteraceae 201174|Actinobacteria T Sigma factor PP2C-like phosphatases - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - BofC_C,PP2C,PP2C_2 k59_240040_2 1458275.AZ34_07370 3.33e-05 46.6 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,4ABW3@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_103954_1 290315.Clim_1841 7.56e-43 145.0 COG1045@1|root,COG1045@2|Bacteria 2|Bacteria E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_103954_2 243233.MCA1435 1.89e-09 58.9 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,1XFCW@135618|Methylococcales 135618|Methylococcales S Glycosyl transferase - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 k59_422108_1 1218084.BBJK01000104_gene6507 2.22e-24 103.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VKW0@28216|Betaproteobacteria,1K459@119060|Burkholderiaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_30943_1 757424.Hsero_0731 7.63e-13 73.2 COG0834@1|root,COG0834@2|Bacteria,1MZ9S@1224|Proteobacteria,2VUII@28216|Betaproteobacteria,478A9@75682|Oxalobacteraceae 28216|Betaproteobacteria ET Periplasmic component of amino acid ABC-type transporter signal transduction system - - - - - - - - - - - - SBP_bac_3 k59_138194_1 1095769.CAHF01000011_gene2515 1.19e-05 46.2 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,472GV@75682|Oxalobacteraceae 28216|Betaproteobacteria H Thiamine pyrophosphate enzyme, N-terminal TPP binding domain ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_422123_1 700598.Niako_0113 2.2e-78 256.0 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,1IR3G@117747|Sphingobacteriia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_954373_1 1121035.AUCH01000020_gene2652 4.46e-93 280.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2VI19@28216|Betaproteobacteria,2KUSM@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor switch protein fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_67311_1 748247.AZKH_3614 3.06e-89 275.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,2WEG5@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_707748_1 1158756.AQXQ01000012_gene1232 8.62e-36 136.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales 135613|Chromatiales S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_138232_1 694427.Palpr_1296 1.44e-62 203.0 COG1088@1|root,COG1088@2|Bacteria,4NE9V@976|Bacteroidetes,2FMUH@200643|Bacteroidia,22W2K@171551|Porphyromonadaceae 976|Bacteroidetes M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1135836_1 1121033.AUCF01000017_gene3875 2.56e-32 130.0 COG3221@1|root,COG4251@1|root,COG3221@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria,2JS9I@204441|Rhodospirillales 204441|Rhodospirillales T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Phosphonate-bd k59_597503_1 1123073.KB899241_gene3460 2.01e-54 180.0 COG3291@1|root,COG3291@2|Bacteria,1QUTU@1224|Proteobacteria,1SNTI@1236|Gammaproteobacteria,1XDC9@135614|Xanthomonadales 135614|Xanthomonadales S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_597506_1 204773.HEAR0457 1.8e-37 140.0 COG3307@1|root,COG3307@2|Bacteria,1NE5R@1224|Proteobacteria,2W9RJ@28216|Betaproteobacteria,4782T@75682|Oxalobacteraceae 28216|Betaproteobacteria M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_31010_1 1198452.Jab_1c03330 8.41e-81 241.0 COG3609@1|root,COG3609@2|Bacteria,1RHNZ@1224|Proteobacteria,2VSYD@28216|Betaproteobacteria,477BB@75682|Oxalobacteraceae 28216|Betaproteobacteria K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - - - - - - - - - - - k59_31010_2 1198452.Jab_1c03340 2.65e-22 87.8 COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2VXYJ@28216|Betaproteobacteria,4755K@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1289) - - - ko:K06938 - - - - ko00000 - - - DUF1289 k59_597528_1 296591.Bpro_0297 3.79e-43 144.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,4AEDR@80864|Comamonadaceae 28216|Betaproteobacteria G PFAM PTS system fructose subfamily IIA component manX - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_597528_2 614083.AWQR01000024_gene2207 2.04e-49 157.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,4AF0H@80864|Comamonadaceae 28216|Betaproteobacteria G TIGRFAM phosphocarrier, HPr family ptsH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_31035_2 1121106.JQKB01000015_gene5771 2.46e-19 80.1 2DPVW@1|root,333MC@2|Bacteria,1N7PY@1224|Proteobacteria,2UHIR@28211|Alphaproteobacteria,2JU4Y@204441|Rhodospirillales 204441|Rhodospirillales C Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers pufB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08927 ko02020,map02020 - - - ko00000,ko00001,ko00194 - - - LHC k59_331149_1 1000565.METUNv1_00875 6.08e-104 308.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VIVI@28216|Betaproteobacteria,2KUVA@206389|Rhodocyclales 206389|Rhodocyclales I 2-hydroxy-3-oxopropionate reductase - - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_969153_1 1116472.MGMO_79c00070 4.85e-45 155.0 COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,1S4R1@1236|Gammaproteobacteria,1XF9H@135618|Methylococcales 135618|Methylococcales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_438585_1 1094466.KQS_02970 9.34e-48 166.0 COG3844@1|root,COG3844@2|Bacteria,4NECS@976|Bacteroidetes,1HWY8@117743|Flavobacteriia,2NSRF@237|Flavobacterium 976|Bacteroidetes E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_969155_1 338969.Rfer_2175 3.4e-107 329.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,4AACI@80864|Comamonadaceae 28216|Betaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_862182_1 1000565.METUNv1_02824 2e-147 423.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,2KUUD@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_400088_1 55529.EKX41805 1.34e-38 139.0 2B66X@1|root,2S0KP@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_611030_1 338969.Rfer_2613 1.2e-42 142.0 COG0720@1|root,COG0720@2|Bacteria,1RETG@1224|Proteobacteria,2VRBN@28216|Betaproteobacteria 28216|Betaproteobacteria H synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_611030_2 338969.Rfer_2614 8.99e-84 252.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,4A9RT@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_899820_1 1123376.AUIU01000016_gene253 4.65e-15 74.3 COG0451@1|root,COG0451@2|Bacteria,3J0XH@40117|Nitrospirae 40117|Nitrospirae GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_899820_2 1500894.JQNN01000001_gene346 4.45e-43 156.0 COG2244@1|root,COG2244@2|Bacteria,1R6ME@1224|Proteobacteria,2VNGZ@28216|Betaproteobacteria,4753X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Polysaccharide biosynthesis protein rfbE - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_331170_1 1000565.METUNv1_01896 4.17e-74 239.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW1@206389|Rhodocyclales 206389|Rhodocyclales JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_293258_2 1123504.JQKD01000004_gene5191 5.17e-32 112.0 COG1942@1|root,COG1942@2|Bacteria,1N7K1@1224|Proteobacteria,2VWGR@28216|Betaproteobacteria,4AF90@80864|Comamonadaceae 28216|Betaproteobacteria G 4-oxalocrotonate tautomerase - - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - Tautomerase k59_293258_3 1123255.JHYS01000002_gene2461 2.09e-38 136.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2VH5Y@28216|Betaproteobacteria,4A9KU@80864|Comamonadaceae 28216|Betaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family dmpH - 4.1.1.77 ko:K01617 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R02602,R05374 RC00751,RC02672 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_470844_1 375286.mma_2736 8.74e-129 375.0 COG0790@1|root,COG0790@2|Bacteria,1PV7Z@1224|Proteobacteria,2WB58@28216|Betaproteobacteria,476BJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - - - - - - - - - - - k59_899831_1 399795.CtesDRAFT_PD4004 9.25e-42 158.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,4ACIR@80864|Comamonadaceae 28216|Betaproteobacteria NU pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM k59_257001_1 543728.Vapar_3497 1.8e-85 266.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,4AAI5@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_862203_1 1055815.AYYA01000044_gene2369 5.5e-29 115.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,3NJKW@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_78452_1 1175306.GWL_39480 7.14e-59 204.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,473SF@75682|Oxalobacteraceae 28216|Betaproteobacteria KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_828323_1 1000565.METUNv1_03752 2.15e-165 469.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,2KUI6@206389|Rhodocyclales 206389|Rhodocyclales U COG3267 Type II secretory pathway, component ExeA - - - - - - - - - - - - AAA_22 k59_1111797_1 1000565.METUNv1_02706 4.04e-98 313.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVC1@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_364179_1 1000565.METUNv1_02456 2.68e-85 272.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - - - - - - - - - - GAF,T2SSE,T2SSE_N k59_1006663_1 1437824.BN940_01726 5.84e-102 311.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VJ3D@28216|Betaproteobacteria,3T1XD@506|Alcaligenaceae 28216|Betaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase dan - 3.5.1.81,3.5.1.82 ko:K01461,ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_6268_1 1000565.METUNv1_03151 3.2e-37 126.0 COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,2KX05@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF883) - - - - - - - - - - - - DUF883 k59_6268_2 1000565.METUNv1_03152 8.59e-62 192.0 COG5393@1|root,COG5393@2|Bacteria,1NDFU@1224|Proteobacteria,2VX3I@28216|Betaproteobacteria,2KWJ8@206389|Rhodocyclales 206389|Rhodocyclales S Putative Actinobacterial Holin-X, holin superfamily III - - - - - - - - - - - - Phage_holin_3_6 k59_6268_4 1000565.METUNv1_03154 3.98e-22 92.4 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,2VRK0@28216|Betaproteobacteria,2KWDG@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_42779_1 1089547.KB913013_gene3440 5.15e-17 84.3 COG5285@1|root,COG5285@2|Bacteria,4NKN2@976|Bacteroidetes,47MM3@768503|Cytophagia 976|Bacteroidetes Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_113000_1 1000565.METUNv1_03261 6.36e-112 339.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,2KUAA@206389|Rhodocyclales 206389|Rhodocyclales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1081326_1 688245.CtCNB1_1973 7.88e-42 143.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,4A9UZ@80864|Comamonadaceae 28216|Betaproteobacteria K Two component transcriptional regulator, winged helix family ompR - - ko:K02483,ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_148455_1 1000565.METUNv1_01159 5.32e-125 369.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria 28216|Betaproteobacteria NT chemotaxis - - - - - - - - - - - - 4HB_MCP_1,HAMP,MCPsignal,sCache_2 k59_899858_1 1000565.METUNv1_03018 1.49e-95 282.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,2KW73@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_1081333_2 1000565.METUNv1_02084 1.46e-80 243.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,2KWJG@206389|Rhodocyclales 206389|Rhodocyclales O COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1081333_3 1000565.METUNv1_02083 4.83e-36 126.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,2KWH7@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_257025_1 1201288.M900_2757 1.5e-38 147.0 COG0354@1|root,COG0457@1|root,COG3071@1|root,COG0354@2|Bacteria,COG0457@2|Bacteria,COG3071@2|Bacteria,1QYGE@1224|Proteobacteria,43CCJ@68525|delta/epsilon subdivisions,2WYDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_1042226_1 883126.HMPREF9710_04480 5.98e-72 239.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria 28216|Betaproteobacteria M Penicillin-binding Protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_438666_1 945543.VIBR0546_20228 6.76e-30 116.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1XVPF@135623|Vibrionales 135623|Vibrionales L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_933372_1 1122604.JONR01000001_gene1697 1.02e-35 136.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RRY3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Sulfatase - - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - DUF4976,Sulfatase k59_828354_1 862908.BMS_0003 2.88e-21 91.7 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,42SYJ@68525|delta/epsilon subdivisions,2MTAS@213481|Bdellovibrionales,2WP80@28221|Deltaproteobacteria 213481|Bdellovibrionales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_828354_2 862908.BMS_0004 2.43e-62 210.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2MSUN@213481|Bdellovibrionales,2WJ9X@28221|Deltaproteobacteria 213481|Bdellovibrionales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_862243_1 883126.HMPREF9710_01177 1.01e-39 143.0 COG0524@1|root,COG0524@2|Bacteria,1PCFU@1224|Proteobacteria,2VK5G@28216|Betaproteobacteria,475TA@75682|Oxalobacteraceae 28216|Betaproteobacteria G pfkB family carbohydrate kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_541038_1 1211777.BN77_p210009 8.59e-14 69.7 COG3938@1|root,COG3938@2|Bacteria,1NVF9@1224|Proteobacteria,2TX8Z@28211|Alphaproteobacteria,4B95T@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the proline racemase family - - 5.1.1.8 ko:K12658 ko00330,map00330 - R03296 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase k59_113029_1 765911.Thivi_0047 1.37e-30 117.0 COG2843@1|root,COG2843@2|Bacteria,1PGVS@1224|Proteobacteria,1RXHX@1236|Gammaproteobacteria,1X1CU@135613|Chromatiales 135613|Chromatiales M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_653002_1 748247.AZKH_2214 3.86e-93 295.0 COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,2WEZZ@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_683584_1 292415.Tbd_1785 1.18e-30 127.0 COG2244@1|root,COG2244@2|Bacteria,1RJUT@1224|Proteobacteria,2VWQE@28216|Betaproteobacteria 28216|Betaproteobacteria S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt k59_1111834_2 1381123.AYOD01000058_gene1696 6.57e-05 45.1 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TSYA@28211|Alphaproteobacteria,43I4S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G probably responsible for the translocation of the substrate across the membrane ugpE - - ko:K02026,ko:K05815 ko02010,map02010 M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 - - BPD_transp_1 k59_438709_1 365044.Pnap_2324 4.29e-30 118.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the NifD NifK NifE NifN family nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_365701_1 1000565.METUNv1_03668 4.47e-101 303.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,2KUAJ@206389|Rhodocyclales 206389|Rhodocyclales C Ubiquinone biosynthesis hydroxylase - - - - - - - - - - - - FAD_binding_2,FAD_binding_3,SE k59_79686_1 1211112.ALJC01000087_gene1033 4.78e-105 312.0 COG0583@1|root,COG0583@2|Bacteria,1NQFK@1224|Proteobacteria,1RP6V@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator, lysr family - - - - - - - - - - - - HTH_1,LysR_substrate k59_190734_1 883126.HMPREF9710_04774 6.56e-05 43.1 COG0526@1|root,COG0526@2|Bacteria,1MZ6D@1224|Proteobacteria,2VU4B@28216|Betaproteobacteria,474TA@75682|Oxalobacteraceae 28216|Betaproteobacteria CO Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_190734_2 1005058.UMN179_02505 2.54e-23 92.4 COG2929@1|root,COG2929@2|Bacteria,1N83Z@1224|Proteobacteria,1SEV2@1236|Gammaproteobacteria,1Y9EU@135625|Pasteurellales 135625|Pasteurellales S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system Z012_04510 - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_190734_3 365044.Pnap_3099 1.89e-06 48.5 COG3514@1|root,COG3514@2|Bacteria,1PSK3@1224|Proteobacteria,2VUXT@28216|Betaproteobacteria,4AFAX@80864|Comamonadaceae 28216|Betaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_1043268_1 1000565.METUNv1_03254 3.39e-20 80.9 COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,2VXTS@28216|Betaproteobacteria,2KXH4@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 k59_1043268_2 1000565.METUNv1_03255 7.18e-26 98.2 COG0594@1|root,COG0594@2|Bacteria,1NNYU@1224|Proteobacteria,2VXXR@28216|Betaproteobacteria,2KXMT@206389|Rhodocyclales 206389|Rhodocyclales J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme - - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_1043268_3 1000565.METUNv1_03256 0.000108 41.2 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2VVTR@28216|Betaproteobacteria,2KX78@206389|Rhodocyclales 206389|Rhodocyclales S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_829802_1 522306.CAP2UW1_0841 5.18e-33 115.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - DUF2442,HNH_5,HTH_3,HTH_31 k59_829802_2 398767.Glov_2136 1.9e-50 160.0 2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,42VC8@68525|delta/epsilon subdivisions,2WT4X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF4160) - - - - - - - - - - - - DUF4160 k59_1083656_1 1000565.METUNv1_02076 3.43e-122 366.0 COG2199@1|root,COG3920@1|root,COG2199@2|Bacteria,COG3920@2|Bacteria,1RGCV@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GAPES3,GGDEF,HATPase_c,MHYT,Reg_prop,SBP_bac_3,Y_Y_Y k59_970264_1 748247.AZKH_1802 3.42e-08 54.3 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,2KVNK@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_970264_2 1000565.METUNv1_00424 2.93e-55 187.0 COG4656@1|root,COG4656@2|Bacteria,1PJVF@1224|Proteobacteria,2VM4P@28216|Betaproteobacteria,2KUV4@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB k59_901392_1 1267005.KB911257_gene664 1.48e-09 64.7 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3N9C0@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1112902_3 189753.AXAS01000014_gene5612 0.00021 48.5 COG5301@1|root,COG5301@2|Bacteria,1QWSJ@1224|Proteobacteria,2TX42@28211|Alphaproteobacteria,3K6RM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_1112902_4 1166948.JPZL01000002_gene1848 4.13e-49 182.0 2EXSU@1|root,33R23@2|Bacteria,1NS77@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_219642_1 1000565.METUNv1_01260 1.24e-92 279.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,2KVKQ@206389|Rhodocyclales 206389|Rhodocyclales O prohibitin homologues - - - - - - - - - - - - Band_7 k59_219642_2 1120973.AQXL01000075_gene964 2.97e-24 100.0 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,2792X@186823|Alicyclobacillaceae 91061|Bacilli O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_333462_1 426117.M446_6117 1.33e-17 87.0 COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2TTNX@28211|Alphaproteobacteria,1JQS4@119045|Methylobacteriaceae 28211|Alphaproteobacteria NT type IV pilus assembly PilZ - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_7654_1 83406.HDN1F_23350 4.01e-20 84.7 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1J6FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_7654_2 1397527.Q670_01620 1.57e-54 190.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XHZK@135619|Oceanospirillales 135619|Oceanospirillales U Type II and III secretion system protein pilQ - - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1008165_1 557598.LHK_00307 2.01e-17 80.5 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,2KSTC@206351|Neisseriales 206351|Neisseriales K B12 binding domain - - - ko:K22491 - - - - ko00000,ko03000 - - - MerR_1 k59_1008165_2 550540.Fbal_2978 2.88e-37 137.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria 1236|Gammaproteobacteria M synthase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - iJN746.PP_2734 CMAS k59_684843_1 322710.Avin_44350 1.26e-36 134.0 COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,1RQ7M@1236|Gammaproteobacteria 1236|Gammaproteobacteria I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf k59_684843_2 1283300.ATXB01000001_gene1372 1.17e-38 140.0 COG1597@1|root,COG1597@2|Bacteria,1RB97@1224|Proteobacteria,1S4B3@1236|Gammaproteobacteria 1236|Gammaproteobacteria I lipid kinase activity - - - - - - - - - - - - Mmp37 k59_970284_1 365044.Pnap_0760 1.25e-72 230.0 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,2VS9P@28216|Betaproteobacteria,4ABK3@80864|Comamonadaceae 28216|Betaproteobacteria U Type II secretion system (T2SS), protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_934598_1 1000565.METUNv1_01900 2.39e-171 487.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VI1T@28216|Betaproteobacteria,2KVXK@206389|Rhodocyclales 206389|Rhodocyclales S Mo-co oxidoreductase dimerisation domain - - - ko:K17225 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Mo-co_dimer,Oxidored_molyb k59_863733_1 1454004.AW11_00446 3.87e-61 207.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1KQJG@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_227836_1 1198452.Jab_1c14750 1.61e-106 317.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,475SF@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_349006_1 1121033.AUCF01000029_gene329 2.43e-22 101.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,Response_reg k59_909748_2 29581.BW37_00039 2.86e-81 249.0 COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,2VH2T@28216|Betaproteobacteria,476VK@75682|Oxalobacteraceae 28216|Betaproteobacteria E Arginine N-succinyltransferase beta subunit astA - 2.3.1.109 ko:K00673 ko00330,ko01100,map00330,map01100 - R00832 RC00004,RC00064 ko00000,ko00001,ko01000 - - - AstA k59_482518_1 338969.Rfer_4073 5.9e-82 262.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria 28216|Betaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - - k59_268726_1 1502852.FG94_04474 4.42e-98 295.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2WFJ1@28216|Betaproteobacteria,47407@75682|Oxalobacteraceae 28216|Betaproteobacteria G UDP-N-acetylglucosamine 2-epimerase wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_694171_1 1122951.ATUE01000005_gene1551 2.66e-62 207.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,3NIIR@468|Moraxellaceae 1236|Gammaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K03820 - - - - ko00000,ko01000 - GT2 iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590 CN_hydrolase k59_1055533_1 1000565.METUNv1_03767 3.31e-66 213.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase group 1 - - - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1,Kdo k59_53666_1 640081.Dsui_3035 3.09e-102 308.0 COG2199@1|root,COG3706@2|Bacteria,1N7HG@1224|Proteobacteria,2VPE2@28216|Betaproteobacteria,2KUP8@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_942515_1 1218084.BBJK01000058_gene4417 4.47e-19 80.1 2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,2VVSC@28216|Betaproteobacteria,1K8Y5@119060|Burkholderiaceae 28216|Betaproteobacteria S biosynthesis protein pqqD - - ko:K06138 - - - - ko00000 - - - PqqD k59_942515_2 1218084.BBJK01000072_gene5081 4.64e-63 198.0 COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2VI0X@28216|Betaproteobacteria,1K36Z@119060|Burkholderiaceae 28216|Betaproteobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_671185_1 765911.Thivi_0693 6.75e-57 200.0 COG0784@1|root,COG2198@1|root,COG4564@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG4564@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2V3@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_88512_1 296591.Bpro_0325 1.71e-33 127.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,4AAYA@80864|Comamonadaceae 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_88512_2 543728.Vapar_4871 8.01e-57 184.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,4AC1G@80864|Comamonadaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_376513_1 1198452.Jab_2c08470 9.96e-10 59.3 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_17336_1 1380387.JADM01000005_gene6 4.24e-24 96.7 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1XJ08@135619|Oceanospirillales 135619|Oceanospirillales K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain sirA - - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_349075_1 420662.Mpe_A3647 4.28e-63 204.0 COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,2VMW2@28216|Betaproteobacteria 28216|Betaproteobacteria P Rhodanese domain protein dedA_2 - - - - - - - - - - - Rhodanese,SNARE_assoc k59_456665_1 1304883.KI912532_gene2153 7.57e-92 293.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,2KUB6@206389|Rhodocyclales 206389|Rhodocyclales ET His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_979604_1 925409.KI911562_gene1818 2.88e-109 341.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,1INQX@117747|Sphingobacteriia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_456670_1 243365.CV_3438 3.35e-49 177.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KQ5R@206351|Neisseriales 206351|Neisseriales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_53701_1 1000565.METUNv1_00585 7.43e-81 264.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_942543_1 1407650.BAUB01000026_gene2776 1.16e-49 162.0 COG0783@1|root,COG0783@2|Bacteria,1G586@1117|Cyanobacteria,1H0B1@1129|Synechococcus 1117|Cyanobacteria P Belongs to the Dps family dps - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_619491_1 748247.AZKH_1206 7.71e-72 231.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,2KV0H@206389|Rhodocyclales 206389|Rhodocyclales F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_671242_1 33905.BTHE_1599 1.84e-07 55.8 COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4CZDW@85004|Bifidobacteriales 201174|Actinobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C k59_17353_2 1000565.METUNv1_01536 7.31e-43 142.0 2EDQM@1|root,337K9@2|Bacteria,1NCVD@1224|Proteobacteria,2VWUM@28216|Betaproteobacteria,2KXG9@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_17353_3 1235457.C404_13850 1.41e-21 93.2 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,1K06F@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_909803_1 1121004.ATVC01000040_gene2393 8.4e-37 142.0 COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VKT5@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9 k59_1092489_1 1304883.KI912532_gene2362 5.62e-88 280.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,2KV3Z@206389|Rhodocyclales 206389|Rhodocyclales C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_160511_1 640511.BC1002_4698 3.08e-35 128.0 COG2159@1|root,COG2159@2|Bacteria,1R7NS@1224|Proteobacteria,2WG6X@28216|Betaproteobacteria,1KIAN@119060|Burkholderiaceae 28216|Betaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_160511_2 1038869.AXAN01000027_gene2404 7.03e-64 204.0 COG3384@1|root,COG3384@2|Bacteria,1R3TY@1224|Proteobacteria,2W1IZ@28216|Betaproteobacteria,1KFSZ@119060|Burkholderiaceae 1224|Proteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - - - - - - - - - - LigB k59_349123_1 1121033.AUCF01000008_gene5761 5.28e-44 163.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,Response_reg k59_671266_1 1123504.JQKD01000026_gene4288 7.17e-67 221.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,4ACH1@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM membrane bound O-acyl transferase MBOAT family protein pacA - - ko:K19294 - - - - ko00000 - - - MBOAT k59_482597_1 365044.Pnap_3578 5.09e-94 277.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,4AC2Q@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_585362_2 83406.HDN1F_16690 5.74e-42 153.0 COG2198@1|root,COG2198@2|Bacteria,1QY43@1224|Proteobacteria,1S0ZB@1236|Gammaproteobacteria,1J4C8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase fimL - - - - - - - - - - - Hpt k59_694246_1 397945.Aave_4743 9.59e-89 270.0 COG0583@1|root,COG0583@2|Bacteria,1QYAP@1224|Proteobacteria,2VHXD@28216|Betaproteobacteria,4ABRM@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, LysR family - - - ko:K21699 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_482609_1 929703.KE386491_gene3347 1.14e-41 155.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,47JIS@768503|Cytophagia 976|Bacteroidetes M Organic solvent tolerance protein OstA - - - - - - - - - - - - - k59_88584_1 1000565.METUNv1_00320 2.21e-72 230.0 COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,2VU2D@28216|Betaproteobacteria,2KX64@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar hook-length control protein fliK - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k59_376584_1 614083.AWQR01000018_gene1901 3.68e-109 327.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,4AB55@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family puuC - 1.2.1.54,1.2.1.8,1.2.1.99 ko:K00130,ko:K09472,ko:K12254 ko00260,ko00330,ko01100,map00260,map00330,map01100 M00136,M00555 R02549,R02565,R02566,R03177,R07417,R07418 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_585386_2 1000565.METUNv1_03341 6.67e-83 254.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,2KVFR@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_552638_1 1000565.METUNv1_00901 1.25e-51 172.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,2KVRU@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_552638_2 1000565.METUNv1_00902 2.47e-44 154.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,2KU8Y@206389|Rhodocyclales 206389|Rhodocyclales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_376591_1 543728.Vapar_1090 2.59e-111 331.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VM4Z@28216|Betaproteobacteria,4ABJ2@80864|Comamonadaceae 28216|Betaproteobacteria S peptidase dimerisation domain protein yxeP_2 - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_909853_1 1122599.AUGR01000011_gene4065 8.22e-09 63.2 COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,1T1XV@1236|Gammaproteobacteria,1XJ40@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - 2.7.13.3 ko:K02480 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,sCache_2 k59_839125_1 1313301.AUGC01000005_gene373 1.8e-23 104.0 COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,4NGRJ@976|Bacteroidetes 976|Bacteroidetes O PFAM Pregnancy-associated plasma protein-A - - - - - - - - - - - - Calx-beta,Cleaved_Adhesin,PKD,Peptidase_M43,fn3 k59_1055732_1 196367.JNFG01000011_gene6149 2.2e-89 270.0 2C967@1|root,2Z7VR@2|Bacteria,1R46W@1224|Proteobacteria,2W8FC@28216|Betaproteobacteria,1K4AU@119060|Burkholderiaceae 28216|Betaproteobacteria S DNA-sulfur modification-associated - - - - - - - - - - - - DndB k59_349240_1 1157708.KB907452_gene3857 2.77e-13 68.2 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,4A9P4@80864|Comamonadaceae 28216|Betaproteobacteria Q Permease MlaE ttg2B - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_349240_2 1504672.669784126 1.2e-62 195.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,4ADFP@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM Mammalian cell entry related domain protein mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_376612_1 575590.HMPREF0156_00935 1.91e-70 226.0 arCOG14100@1|root,2Z924@2|Bacteria,4NEE9@976|Bacteroidetes 976|Bacteroidetes S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_942622_1 338969.Rfer_0728 3.23e-48 166.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,4AA2G@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,S4_2,tRNA-synt_1b k59_804428_1 925409.KI911562_gene555 2.18e-93 282.0 COG0473@1|root,COG0473@2|Bacteria,4NEBE@976|Bacteroidetes,1INYR@117747|Sphingobacteriia 976|Bacteroidetes C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_349258_1 1348657.M622_02655 4.32e-49 170.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VHBK@28216|Betaproteobacteria,2KVTF@206389|Rhodocyclales 206389|Rhodocyclales V COG0286 Type I restriction-modification system methyltransferase subunit - - - - - - - - - - - - HsdM_N,N6_Mtase k59_349270_1 945713.IALB_0237 2.23e-07 58.2 COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3290@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_552688_2 1000565.METUNv1_03863 2.39e-82 248.0 COG0457@1|root,COG0457@2|Bacteria,1QVJZ@1224|Proteobacteria 1224|Proteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 k59_528153_1 946483.Cenrod_1359 2.53e-131 383.0 COG3664@1|root,COG3664@2|Bacteria,1MX9Q@1224|Proteobacteria,2W20Q@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM glycoside hydrolase family 39 - - - - - - - - - - - - - k59_306230_1 159087.Daro_2264 8.58e-68 222.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,2KW8G@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23 k59_839166_1 1123487.KB892834_gene2990 8.53e-08 59.3 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVEE@206389|Rhodocyclales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg k59_456860_2 313624.NSP_25570 5.8e-61 196.0 COG2189@1|root,COG2189@2|Bacteria,1G2XK@1117|Cyanobacteria,1HU8N@1161|Nostocales 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_17467_1 365046.Rta_34700 8.97e-101 296.0 2DBAF@1|root,2Z82V@2|Bacteria,1MWRM@1224|Proteobacteria,2VM7J@28216|Betaproteobacteria,4AD3J@80864|Comamonadaceae 28216|Betaproteobacteria S CRISPR-associated protein (Cas_Cas5) cas5d - - ko:K19119 - - - - ko00000,ko02048 - - - Cas_Cas5d k59_17467_2 1033802.SSPSH_003226 0.000633 43.5 28HN3@1|root,2Z7WH@2|Bacteria,1MWH8@1224|Proteobacteria,1RYMP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S crispr-associated protein - - - ko:K19117 - - - - ko00000,ko02048 - - - Cas_Csd1 k59_528170_1 1115515.EV102420_30_00540 1.39e-110 327.0 COG3817@1|root,COG3817@2|Bacteria,1MXGD@1224|Proteobacteria,1RNC0@1236|Gammaproteobacteria,3XQNJ@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF979) - - - - - - - - - - - - DUF979 k59_979734_1 983917.RGE_20480 4.02e-171 496.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2VJ6Z@28216|Betaproteobacteria,1KN6U@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) phoX - - ko:K07093 - - - - ko00000 - - - DUF839 k59_911196_1 1005048.CFU_4384 4.05e-87 270.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VHEY@28216|Betaproteobacteria,47231@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor gabR_6 - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_55357_1 1242864.D187_003164 3.79e-76 248.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,42QQG@68525|delta/epsilon subdivisions,2WMXN@28221|Deltaproteobacteria,2YXY4@29|Myxococcales 28221|Deltaproteobacteria G Ricin-type beta-trefoil gdhB - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH,Ricin_B_lectin k59_620636_1 1000565.METUNv1_03803 9.24e-79 253.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,2KUHM@206389|Rhodocyclales 206389|Rhodocyclales S Dynamin family - - - - - - - - - - - - Dynamin_N k59_805863_1 1232410.KI421418_gene2208 4.38e-95 293.0 COG1215@1|root,COG1215@2|Bacteria,1R9CM@1224|Proteobacteria 1224|Proteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_840929_1 543728.Vapar_5021 1.33e-34 129.0 COG1522@1|root,COG1940@1|root,COG1522@2|Bacteria,COG1940@2|Bacteria,1NFM0@1224|Proteobacteria,2WG1U@28216|Betaproteobacteria,4AGIZ@80864|Comamonadaceae 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - HTH_24,ROK k59_840929_2 595537.Varpa_5737 1.56e-26 103.0 COG1129@1|root,COG1129@2|Bacteria,1P3ZB@1224|Proteobacteria,2VKUZ@28216|Betaproteobacteria,4AH6G@80864|Comamonadaceae 28216|Betaproteobacteria G ATPases associated with a variety of cellular activities - - 3.6.3.17 ko:K02056,ko:K10545 ko02010,map02010 M00215,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.4 - - ABC_tran k59_586734_1 1122951.ATUE01000008_gene269 1.34e-24 94.4 COG1145@1|root,COG1145@2|Bacteria,1NC5J@1224|Proteobacteria,1SSZ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 k59_1058055_1 1198452.Jab_2c27280 3.18e-69 216.0 COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,2VHT7@28216|Betaproteobacteria,473BU@75682|Oxalobacteraceae 28216|Betaproteobacteria U ABC-2 type transporter - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_1058055_2 1198452.Jab_2c27240 9.8e-34 121.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,476D2@75682|Oxalobacteraceae 28216|Betaproteobacteria K Bacterial regulatory proteins, crp family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_981148_1 1300345.LF41_2549 1.45e-60 197.0 296I5@1|root,2ZTTN@2|Bacteria,1RFYP@1224|Proteobacteria,1SYR3@1236|Gammaproteobacteria,1X9H9@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF2785) - - - - - - - - - - - - DUF2785 k59_554470_1 1238190.AMQY01000025_gene3 5.75e-08 55.1 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XI42@135619|Oceanospirillales 135619|Oceanospirillales NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_554470_2 452637.Oter_2550 2.48e-39 137.0 COG0745@1|root,COG0745@2|Bacteria,46SS3@74201|Verrucomicrobia,3K7XM@414999|Opitutae 414999|Opitutae K Two component transcriptional regulator, winged helix family - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_378090_2 755732.Fluta_2324 4.59e-30 119.0 COG0306@1|root,COG0306@2|Bacteria,4NE7J@976|Bacteroidetes,1I0VI@117743|Flavobacteriia 976|Bacteroidetes P phosphate transporter pitA - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_321968_1 1196835.A458_20165 5.83e-55 187.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,1RYEY@1236|Gammaproteobacteria,1Z2HH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family intF GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896 - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_714448_1 998674.ATTE01000001_gene1473 9.82e-132 389.0 COG1653@1|root,COG1653@2|Bacteria,1MXZJ@1224|Proteobacteria,1RRP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K10232 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 - - SBP_bac_1 k59_36258_1 1000565.METUNv1_00204 2.95e-53 167.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,2KX43@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_36258_2 1000565.METUNv1_00205 4.81e-64 196.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KWM1@206389|Rhodocyclales 206389|Rhodocyclales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_36258_3 1000565.METUNv1_00206 2.03e-36 130.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,2KV65@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_286100_1 1384056.N787_03860 8.86e-47 166.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,1X379@135614|Xanthomonadales 135614|Xanthomonadales H AbgT putative transporter family - - - - - - - - - - - - ABG_transport k59_429020_1 1000565.METUNv1_03510 2.06e-122 362.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,2KU70@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1035630_1 1000565.METUNv1_01879 7.62e-38 137.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KURK@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_321978_1 269798.CHU_2678 2.28e-16 73.6 COG1983@1|root,COG1983@2|Bacteria,4NUNU@976|Bacteroidetes,47RWN@768503|Cytophagia 976|Bacteroidetes KT PFAM PspC domain - - - - - - - - - - - - PspC k59_179206_1 261292.Nit79A3_0883 0.000179 43.1 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,371YV@32003|Nitrosomonadales 28216|Betaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_179206_3 1458427.BAWN01000006_gene422 7.48e-26 99.0 COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VT4U@28216|Betaproteobacteria,4AJIV@80864|Comamonadaceae 28216|Betaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_393231_1 1198452.Jab_2c19000 4.44e-60 206.0 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,2VH7D@28216|Betaproteobacteria,476TK@75682|Oxalobacteraceae 28216|Betaproteobacteria O DNA-K related protein - - - - - - - - - - - - DUF3731,HSP70 k59_393231_2 1198452.Jab_2c18990 2.05e-10 60.1 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,2VJ41@28216|Betaproteobacteria,47652@75682|Oxalobacteraceae 28216|Betaproteobacteria O Hsp70 protein - - - - - - - - - - - - HSP70 k59_1071547_1 1000565.METUNv1_02946 3.69e-159 451.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,2KUY8@206389|Rhodocyclales 206389|Rhodocyclales M acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_107539_1 977880.RALTA_B1435 4.17e-63 208.0 COG1835@1|root,COG1835@2|Bacteria,1NSVZ@1224|Proteobacteria,2VKZ5@28216|Betaproteobacteria,1K8TN@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_785883_1 999541.bgla_1g03870 8.13e-08 49.7 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_785883_2 596154.Alide2_0851 9.44e-76 226.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,4AE73@80864|Comamonadaceae 28216|Betaproteobacteria FG Histidine triad (Hit) protein hitA - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_143309_1 1000565.METUNv1_02295 5.42e-101 308.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,2KU69@206389|Rhodocyclales 206389|Rhodocyclales C Sulfite reductase cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_571481_1 743299.Acife_2178 3.03e-88 278.0 COG0419@1|root,COG0419@2|Bacteria,1R8F1@1224|Proteobacteria,1RQ6D@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ATPase involved in DNA repair - - - - - - - - - - - - AAA_23 k59_821454_1 1000565.METUNv1_00446 2.48e-95 290.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VJRK@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1,Glu_cyclase_2,Lactonase k59_964140_1 1234364.AMSF01000058_gene851 5.62e-104 305.0 COG0286@1|root,COG0286@2|Bacteria,1NRAS@1224|Proteobacteria,1SN7R@1236|Gammaproteobacteria 1236|Gammaproteobacteria V site-specific DNA-methyltransferase (adenine-specific) activity - - - - - - - - - - - - - k59_714478_2 1000565.METUNv1_00397 2.31e-236 652.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,2KUKP@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_535836_1 420662.Mpe_A1392 2.2e-155 444.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,1KJ7A@119065|unclassified Burkholderiales 28216|Betaproteobacteria P NMT1-like family nasF - - ko:K02051,ko:K15576,ko:K22067 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000,ko02022 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - NMT1_2 k59_36282_1 1000565.METUNv1_00583 5.28e-182 512.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,2KV9X@206389|Rhodocyclales 28216|Betaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5,6.2.1.9 ko:K01903,ko:K14067 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_750023_1 1349767.GJA_1958 9.21e-100 301.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VJ87@28216|Betaproteobacteria,472QN@75682|Oxalobacteraceae 28216|Betaproteobacteria U Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate dctA - - ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - - SDF k59_652_1 1000565.METUNv1_00046 5.52e-241 716.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_821460_1 1000565.METUNv1_02015 4.52e-170 523.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,2KVBJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_999953_1 925409.KI911562_gene1042 2.87e-93 281.0 COG1173@1|root,COG1173@2|Bacteria,4NGTQ@976|Bacteroidetes,1IQI5@117747|Sphingobacteriia 976|Bacteroidetes EP PFAM Binding-protein-dependent transport system inner membrane component dppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_785926_1 1408433.JHXV01000004_gene3405 1.32e-15 76.3 COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,1HXDA@117743|Flavobacteriia,2PBBH@246874|Cryomorphaceae 976|Bacteroidetes M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.23 ko:K13019 ko00520,map00520 - R09600 RC00290 ko00000,ko00001,ko01000,ko01005 - - - Epimerase_2 k59_785926_2 867900.Celly_2127 5.15e-26 107.0 COG0726@1|root,COG0726@2|Bacteria,4NF79@976|Bacteroidetes,1HWXT@117743|Flavobacteriia,1F8M7@104264|Cellulophaga 976|Bacteroidetes G polysaccharide deacetylase - - - - - - - - - - - - - k59_429086_1 1000565.METUNv1_00667 1.17e-16 77.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,2KUC0@206389|Rhodocyclales 206389|Rhodocyclales I phytoene - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_429086_2 1000565.METUNv1_00669 3.39e-80 243.0 COG0500@1|root,COG0500@2|Bacteria,1RDRV@1224|Proteobacteria,2WI0N@28216|Betaproteobacteria,2KZY2@206389|Rhodocyclales 206389|Rhodocyclales H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_179269_2 1000565.METUNv1_00825 3.64e-21 96.3 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2VJHA@28216|Betaproteobacteria,2KWAS@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_286153_1 1000565.METUNv1_01474 3.87e-94 280.0 COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,2VTJW@28216|Betaproteobacteria,2KYZQ@206389|Rhodocyclales 206389|Rhodocyclales S Histidine biosynthesis protein - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_714512_1 1000565.METUNv1_02949 4.47e-151 432.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,2KURQ@206389|Rhodocyclales 206389|Rhodocyclales C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_714512_2 1000565.METUNv1_02950 7.24e-134 390.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KUV1@206389|Rhodocyclales 206389|Rhodocyclales S modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_250465_1 614083.AWQR01000018_gene1908 3.19e-12 64.7 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VQGX@28216|Betaproteobacteria,4ADSX@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidase C26 puuD - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_250465_2 614083.AWQR01000018_gene1909 7.84e-59 196.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VHEY@28216|Betaproteobacteria,4A9Y8@80864|Comamonadaceae 28216|Betaproteobacteria K aminotransferase class I and II gabR_6 - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_643316_1 749222.Nitsa_1810 5.54e-35 125.0 2C2E9@1|root,32RAA@2|Bacteria,1RF5M@1224|Proteobacteria,433I8@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_322058_1 29581.BW37_05342 4.02e-31 110.0 COG2501@1|root,COG2501@2|Bacteria,1N7NW@1224|Proteobacteria,2VVQY@28216|Betaproteobacteria,4752X@75682|Oxalobacteraceae 28216|Betaproteobacteria S S4 domain ybcJ - - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 k59_322058_2 883126.HMPREF9710_03744 5.65e-16 71.6 2AG4B@1|root,3168Z@2|Bacteria,1PX39@1224|Proteobacteria,2WCKQ@28216|Betaproteobacteria,477UY@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_535867_1 1000565.METUNv1_02547 1.81e-98 291.0 28JUM@1|root,2Z9JN@2|Bacteria,1NDV6@1224|Proteobacteria,2VJ3P@28216|Betaproteobacteria,2KWGF@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_678637_1 614083.AWQR01000027_gene3783 4.41e-137 393.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VJCQ@28216|Betaproteobacteria,4AB5Q@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_429104_1 1000565.METUNv1_01659 1.9e-251 702.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,2KZRQ@206389|Rhodocyclales 206389|Rhodocyclales H Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_750053_1 1000565.METUNv1_00042 4.47e-121 347.0 COG1309@1|root,COG1309@2|Bacteria,1N659@1224|Proteobacteria,2VS47@28216|Betaproteobacteria,2KX9V@206389|Rhodocyclales 206389|Rhodocyclales K MAATS-type transcriptional repressor, C-terminal region - - - ko:K03577 - M00647 - - ko00000,ko00002,ko03000 - - - TetR_C_2,TetR_N k59_750053_2 1000565.METUNv1_00041 2.5e-188 540.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,2KUWP@206389|Rhodocyclales 206389|Rhodocyclales O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_3 k59_698_1 485918.Cpin_3979 4.56e-06 48.5 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator narL - - ko:K02485,ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_698_2 1340493.JNIF01000003_gene4543 3.18e-12 67.4 COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria 57723|Acidobacteria L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_785953_1 1000565.METUNv1_00321 4.07e-61 191.0 COG2882@1|root,COG2882@2|Bacteria,1N21N@1224|Proteobacteria,2VU9D@28216|Betaproteobacteria,2KWXQ@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar export protein FliJ fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ k59_785953_2 1000565.METUNv1_00322 1.27e-217 608.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2VHQ5@28216|Betaproteobacteria,2KUH3@206389|Rhodocyclales 206389|Rhodocyclales NU ATPase FliI YscN family fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab k59_214647_1 338969.Rfer_0385 2.98e-38 139.0 COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2VN6N@28216|Betaproteobacteria,4AEZ2@80864|Comamonadaceae 28216|Betaproteobacteria C e3 binding domain - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_214647_2 1366050.N234_08605 5.93e-29 105.0 COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2VWCN@28216|Betaproteobacteria,1KA3Y@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_214647_3 1163409.UUA_11288 2.09e-85 264.0 COG3000@1|root,COG3000@2|Bacteria,1R763@1224|Proteobacteria,1S0C8@1236|Gammaproteobacteria,1X5RH@135614|Xanthomonadales 135614|Xanthomonadales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_179302_1 1000565.METUNv1_01603 1.11e-172 496.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VR0W@28216|Betaproteobacteria,2KXU2@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_357666_1 1000565.METUNv1_02299 2.58e-227 664.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VPB3@28216|Betaproteobacteria,2KVVY@206389|Rhodocyclales 206389|Rhodocyclales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_4,TPR_8 k59_964711_1 748247.AZKH_3165 1.88e-39 145.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VQA9@28216|Betaproteobacteria,2KY7M@206389|Rhodocyclales 206389|Rhodocyclales J Hydantoinase B/oxoprolinase - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_964711_2 322710.Avin_11370 3.93e-76 234.0 28KRF@1|root,2ZA8Z@2|Bacteria,1R9AM@1224|Proteobacteria,1S9YY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_286866_1 1449076.JOOE01000003_gene3378 3.29e-36 133.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,2JZZ1@204457|Sphingomonadales 204457|Sphingomonadales P cation diffusion facilitator family transporter - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_286866_2 243365.CV_1359 2.82e-45 154.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KR4C@206351|Neisseriales 206351|Neisseriales S Psort location CytoplasmicMembrane, score 9.46 - - - - - - - - - - - - UPF0016 k59_465270_1 365044.Pnap_2519 1.94e-131 389.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria,4AC3U@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ABC-1 domain protein - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_679142_2 1198452.Jab_2c30570 9.28e-73 229.0 COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,2VNQ8@28216|Betaproteobacteria,473SU@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyl transferase 4-like wbpZ - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_143937_1 1000565.METUNv1_01506 4.26e-158 458.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,2KUDK@206389|Rhodocyclales 206389|Rhodocyclales H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_822076_1 1123487.KB892838_gene3869 7.57e-61 196.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,2KU8S@206389|Rhodocyclales 206389|Rhodocyclales J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_822080_1 925409.KI911562_gene2272 4.28e-68 218.0 COG2259@1|root,COG2259@2|Bacteria,4NGNF@976|Bacteroidetes,1IPIJ@117747|Sphingobacteriia 976|Bacteroidetes O DoxX family doxX - - - - - - - - - - - DoxX k59_893580_1 614083.AWQR01000002_gene2989 6.72e-76 243.0 COG0457@1|root,COG0457@2|Bacteria,1NNCT@1224|Proteobacteria,2VK0Z@28216|Betaproteobacteria,4ACBW@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_8 k59_36958_1 1000565.METUNv1_00740 7.82e-69 213.0 COG3167@1|root,COG3167@2|Bacteria,1NEXJ@1224|Proteobacteria,2VX69@28216|Betaproteobacteria,2KXE3@206389|Rhodocyclales 206389|Rhodocyclales NU carbon utilization - - - - - - - - - - - - - k59_36958_2 1000565.METUNv1_00739 8.09e-78 238.0 29FH2@1|root,302EQ@2|Bacteria,1PVA7@1224|Proteobacteria,2WB6K@28216|Betaproteobacteria,2KXNM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_750593_2 375286.mma_0871 1.17e-05 48.1 COG0477@1|root,COG2814@2|Bacteria,1PE5A@1224|Proteobacteria,2VHTJ@28216|Betaproteobacteria,473JI@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Uncharacterised MFS-type transporter YbfB emrB_1 - - - - - - - - - - - MFS_1,Sugar_tr k59_1107574_1 477228.YO5_11110 1.96e-08 56.2 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,1RN84@1236|Gammaproteobacteria,1Z10V@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_1107574_2 1000565.METUNv1_03345 4.42e-126 363.0 COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,2VI8R@28216|Betaproteobacteria,2KUIF@206389|Rhodocyclales 206389|Rhodocyclales C Cob(II)yrinic acid a,c-diamide reductase - - 1.13.11.79 ko:K04719 ko00740,ko01100,map00740,map01100 - R09083 RC00435,RC02413 ko00000,ko00001,ko01000 - - - Nitroreductase k59_1107574_3 266264.Rmet_3938 2.24e-71 230.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria,1K1C9@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 k59_322959_1 1000565.METUNv1_03988 3.23e-121 349.0 COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,2VIX6@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the UPF0176 family - - - ko:K07146 - - - - ko00000 - - - Rhodanese k59_786678_1 1000565.METUNv1_02785 2.61e-138 401.0 COG0705@1|root,COG0705@2|Bacteria,1PRTS@1224|Proteobacteria,2VM82@28216|Betaproteobacteria,2KXF8@206389|Rhodocyclales 206389|Rhodocyclales S Rhomboid family - - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Rhomboid k59_607556_1 864073.HFRIS_021738 2.14e-09 55.1 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,474RA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Mycobacterial 4 TMS phage holin, superfamily IV - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_822092_1 649638.Trad_0736 8.67e-47 164.0 COG0438@1|root,COG0438@2|Bacteria,1WJTX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_644234_1 864051.BurJ1DRAFT_4162 1.57e-74 238.0 COG2010@1|root,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria,1KNJH@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,DUF302 k59_251158_1 1000565.METUNv1_00266 1.63e-125 366.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales 206389|Rhodocyclales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_928786_1 1000565.METUNv1_02937 2.08e-184 522.0 COG1366@1|root,COG1366@2|Bacteria,1R08G@1224|Proteobacteria,2VIGK@28216|Betaproteobacteria,2KVYW@206389|Rhodocyclales 206389|Rhodocyclales T Belongs to the anti-sigma-factor antagonist family - - - - - - - - - - - - STAS_2 k59_394034_1 614083.AWQR01000010_gene1542 2.37e-17 80.1 COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria,4AAHV@80864|Comamonadaceae 28216|Betaproteobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_394034_2 614083.AWQR01000010_gene1541 4.91e-66 209.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,4AC0J@80864|Comamonadaceae 28216|Betaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_822104_1 1000565.METUNv1_00944 8.14e-111 335.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,2KUXB@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_607573_1 929558.SMGD1_1451 7.89e-30 122.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YN16@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GGDEF EAL family protein - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_576008_1 29581.BW37_04465 8.49e-48 158.0 COG1305@1|root,COG1305@2|Bacteria,1R4TK@1224|Proteobacteria,2VQIV@28216|Betaproteobacteria,474T7@75682|Oxalobacteraceae 28216|Betaproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_1111407_1 666681.M301_0043 1.19e-39 144.0 28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1111407_2 317013.NY99_07500 4.68e-11 60.8 COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,1SEV5@1236|Gammaproteobacteria,1X8UI@135614|Xanthomonadales 135614|Xanthomonadales C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_112543_2 497964.CfE428DRAFT_3536 5.95e-58 189.0 COG1376@1|root,COG1376@2|Bacteria,46VIF@74201|Verrucomicrobia 2|Bacteria S PFAM ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - PG_binding_1,YkuD k59_899306_1 864051.BurJ1DRAFT_2239 3.15e-20 97.1 COG1361@1|root,COG2304@1|root,COG2931@1|root,COG2982@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q TIGRFAM outer membrane adhesin like proteiin - - - - - - - - - - - - Cadherin_3,DUF4347,He_PIG,HemolysinCabind,VWA_2 k59_5827_1 1266925.JHVX01000006_gene2063 7.61e-34 135.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2VKKT@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_437789_1 640081.Dsui_2686 4.08e-93 293.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_683163_1 629265.PMA4326_19605 2.28e-72 226.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,1Z9IH@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR2 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_861713_1 358220.C380_23260 6.67e-70 230.0 COG3307@1|root,COG3307@2|Bacteria,1R841@1224|Proteobacteria,2WFP2@28216|Betaproteobacteria,4AB0I@80864|Comamonadaceae 28216|Betaproteobacteria M O-antigen ligase like membrane protein - - - - - - - - - - - - PglL_A,Wzy_C,Wzy_C_2 k59_791818_1 1000565.METUNv1_00693 2.86e-120 353.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VMT8@28216|Betaproteobacteria,2KV87@206389|Rhodocyclales 206389|Rhodocyclales M Phospholipase A1 - - - - - - - - - - - - PLA1 k59_791818_2 1000565.METUNv1_00692 0.0 934.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VP9Y@28216|Betaproteobacteria,2KVNY@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_791818_3 1000565.METUNv1_00691 3.29e-71 225.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria,2KW07@206389|Rhodocyclales 206389|Rhodocyclales S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_42330_1 614083.AWQR01000009_gene600 3.24e-24 101.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VN72@28216|Betaproteobacteria 28216|Betaproteobacteria M Pfam Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721,ko:K00786 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA,PMT_2 k59_42330_2 1268622.AVS7_01593 2.41e-30 107.0 COG1942@1|root,COG1942@2|Bacteria,1N8I6@1224|Proteobacteria,2VW8C@28216|Betaproteobacteria,4AFEI@80864|Comamonadaceae 28216|Betaproteobacteria G 4-oxalocrotonate tautomerase - - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - Tautomerase k59_42330_3 338969.Rfer_0766 1.4e-21 90.9 COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,2VJP1@28216|Betaproteobacteria,4AC4S@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Glutamine amidotransferase, class-II yafJ - - - - - - - - - - - GATase_4 k59_147890_1 1000565.METUNv1_03068 1.37e-91 288.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KV2P@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_147890_2 1000565.METUNv1_03069 1.68e-73 232.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,2KV57@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2 k59_5845_1 1500894.JQNN01000001_gene467 2e-90 276.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family nolF - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_77950_1 1000565.METUNv1_00655 0.0 923.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,2KVGD@206389|Rhodocyclales 206389|Rhodocyclales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1080499_1 748247.AZKH_4524 4.83e-26 109.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VNQ5@28216|Betaproteobacteria,2KZTM@206389|Rhodocyclales 206389|Rhodocyclales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_1006063_1 398578.Daci_2776 1.55e-103 303.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,4ABQK@80864|Comamonadaceae 28216|Betaproteobacteria C cytochrome c oxidase, cbb3-type, subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_683175_1 1000565.METUNv1_00375 3.05e-07 52.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_683175_2 1000565.METUNv1_00374 4.93e-309 867.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KUIP@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_292768_1 1000565.METUNv1_02155 9.83e-140 399.0 COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,2VK7W@28216|Betaproteobacteria,2KVGX@206389|Rhodocyclales 206389|Rhodocyclales D Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_292768_2 1000565.METUNv1_02156 7.46e-148 423.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,2KVPQ@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_509140_1 929562.Emtol_3684 0.000219 48.9 COG1506@1|root,COG1506@2|Bacteria,4NGW1@976|Bacteroidetes,47MCA@768503|Cytophagia 976|Bacteroidetes E Secretory lipase - - - - - - - - - - - - LIP,Peptidase_S9 k59_1006081_2 1000565.METUNv1_01305 2.55e-49 162.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,2KV4J@206389|Rhodocyclales 206389|Rhodocyclales F Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage - - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_610775_2 1120977.JHUX01000005_gene2696 1.24e-111 350.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,3NJ42@468|Moraxellaceae 1236|Gammaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_4025 PEPcase k59_112581_1 1123257.AUFV01000001_gene1939 5.41e-54 189.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2I5@1236|Gammaproteobacteria,1X59N@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_187758_1 1100720.ALKN01000030_gene1164 1.14e-82 262.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,4AAM2@80864|Comamonadaceae 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1041883_1 1121022.ABENE_04845 8.45e-44 159.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_5 k59_187760_1 1288494.EBAPG3_190 9.61e-84 259.0 COG1055@1|root,COG1055@2|Bacteria,1N68M@1224|Proteobacteria,2VH3A@28216|Betaproteobacteria,371YR@32003|Nitrosomonadales 28216|Betaproteobacteria P Putative Na+/H+ antiporter - - - - - - - - - - - - Na_H_antiport_3 k59_576057_1 929556.Solca_2915 9.61e-80 250.0 COG0477@1|root,COG2814@2|Bacteria,4NESW@976|Bacteroidetes,1IPCU@117747|Sphingobacteriia 976|Bacteroidetes EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_112595_1 279714.FuraDRAFT_0338 5.29e-104 320.0 COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria,2KQNM@206351|Neisseriales 206351|Neisseriales C Cytochrome C oxidase subunit II, periplasmic domain protein nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_861756_1 1000565.METUNv1_00171 1.11e-89 281.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,2KV11@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1006104_1 504472.Slin_1136 3.15e-10 66.6 COG1629@1|root,COG4771@2|Bacteria,4PN3U@976|Bacteroidetes,47Y97@768503|Cytophagia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_330516_1 1000565.METUNv1_02917 6.81e-43 151.0 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,2KVTK@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_330516_3 1000565.METUNv1_02919 3.65e-22 92.4 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KUJH@206389|Rhodocyclales 206389|Rhodocyclales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_1111462_1 1235457.C404_05185 3.3e-41 144.0 COG0583@1|root,COG0583@2|Bacteria,1QFR1@1224|Proteobacteria,2VIBT@28216|Betaproteobacteria,1K74X@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1111462_2 1235457.C404_05180 3.36e-26 101.0 COG1280@1|root,COG1280@2|Bacteria,1RD4I@1224|Proteobacteria,2VQ25@28216|Betaproteobacteria,1K7ZZ@119060|Burkholderiaceae 28216|Betaproteobacteria E efflux protein - - - - - - - - - - - - LysE k59_218546_1 1000565.METUNv1_02919 7.72e-117 342.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KUJH@206389|Rhodocyclales 206389|Rhodocyclales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_187794_1 1123367.C666_08740 2.05e-59 197.0 COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2VKCH@28216|Betaproteobacteria 28216|Betaproteobacteria Q 4-hydroxyphenylacetate - - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_187794_2 754477.Q7C_1396 2.27e-19 85.5 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,1S7F3@1236|Gammaproteobacteria,462YT@72273|Thiotrichales 72273|Thiotrichales Q PFAM Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_78014_1 1000565.METUNv1_00690 4.65e-125 373.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2VPXS@28216|Betaproteobacteria,2KVYX@206389|Rhodocyclales 206389|Rhodocyclales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_576084_1 1215092.PA6_009_00950 1.34e-57 195.0 COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_652258_1 1198452.Jab_1c12220 8.45e-47 164.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,472N5@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_256618_1 1000565.METUNv1_03016 2.47e-262 737.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,2KV6T@206389|Rhodocyclales 206389|Rhodocyclales K RNA binding - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_330567_1 1000565.METUNv1_02575 4.17e-118 364.0 COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,2VN60@28216|Betaproteobacteria,2KYVB@206389|Rhodocyclales 206389|Rhodocyclales L DEAD-like helicases superfamily - - - - - - - - - - - - - k59_330567_2 338969.Rfer_3900 7.39e-07 50.4 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,4AJCJ@80864|Comamonadaceae 28216|Betaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,HTH_DeoR,WYL k59_1080628_1 296591.Bpro_2320 1.22e-31 117.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,4AA8R@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1080628_2 614083.AWQR01000005_gene964 4.48e-43 152.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,4AAW6@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_719900_1 305700.B447_10967 3.11e-22 92.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,2VTYZ@28216|Betaproteobacteria,2KXFY@206389|Rhodocyclales 206389|Rhodocyclales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_719900_2 1000565.METUNv1_03645 1.94e-35 129.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,2KUUY@206389|Rhodocyclales 206389|Rhodocyclales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_256629_1 1410670.JHXF01000015_gene2274 4.11e-47 176.0 COG3378@1|root,COG4983@1|root,COG3378@2|Bacteria,COG4983@2|Bacteria,1TQP9@1239|Firmicutes,24AY6@186801|Clostridia,3WHX7@541000|Ruminococcaceae 186801|Clostridia S Phage plasmid primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,PriCT_1,Prim-Pol k59_1041928_1 522306.CAP2UW1_2714 2.17e-37 130.0 297U7@1|root,2ZV0V@2|Bacteria,1RE3I@1224|Proteobacteria,2VRCN@28216|Betaproteobacteria,1KQQQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1041928_2 1205753.A989_14427 2.37e-10 58.5 COG3070@1|root,COG3070@2|Bacteria,1N0ND@1224|Proteobacteria,1SE8F@1236|Gammaproteobacteria,1X7XP@135614|Xanthomonadales 135614|Xanthomonadales K TfoX N-terminal domain - - - - - - - - - - - - TfoX_N k59_5927_1 58123.JOFJ01000013_gene4927 0.000221 47.0 COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria,4EG93@85012|Streptosporangiales 201174|Actinobacteria P Periplasmic binding protein yvrC - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_509251_1 497964.CfE428DRAFT_6349 2.7e-40 146.0 COG3039@1|root,COG3039@2|Bacteria,46WXW@74201|Verrucomicrobia 74201|Verrucomicrobia L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_683239_1 1121035.AUCH01000015_gene2598 1.71e-66 214.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KUAY@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_683239_2 1304883.KI912532_gene3236 8.29e-06 45.1 COG4390@1|root,COG4390@2|Bacteria,1N8RK@1224|Proteobacteria,2VUJW@28216|Betaproteobacteria,2KWNK@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - - - - - - - - - - DUF2322 k59_719910_1 981383.AEWH01000035_gene861 7.28e-54 173.0 COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli 91061|Bacilli J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_719910_2 1340493.JNIF01000003_gene3220 1.16e-25 95.9 COG0199@1|root,COG0199@2|Bacteria,3Y5HM@57723|Acidobacteria 57723|Acidobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_754679_1 497964.CfE428DRAFT_4282 5.13e-115 336.0 COG1013@1|root,COG1013@2|Bacteria,46SRY@74201|Verrucomicrobia 74201|Verrucomicrobia C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1111488_1 4555.Si020795m 8.19e-275 766.0 COG0843@1|root,KOG4769@2759|Eukaryota,37QZZ@33090|Viridiplantae,3GEEJ@35493|Streptophyta,3KME8@4447|Liliopsida,3IAIW@38820|Poales 35493|Streptophyta C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B cox1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902600 1.9.3.1 ko:K02256 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko01000,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX1 k59_1111488_2 1123488.ATUF01000004_gene1612 2.25e-06 56.6 COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4D4CF@85005|Actinomycetales 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_78059_1 365044.Pnap_1919 1.46e-31 119.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VJI2@28216|Betaproteobacteria,4AAGM@80864|Comamonadaceae 28216|Betaproteobacteria EJ PFAM Asparaginase glutaminase ansB - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_78059_2 1000565.METUNv1_03200 1.17e-41 149.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVBI@206389|Rhodocyclales 206389|Rhodocyclales JKL Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_187883_1 313606.M23134_07566 6.77e-62 214.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47P32@768503|Cytophagia 976|Bacteroidetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_1006919_2 866771.HMPREF9296_0461 7.19e-16 75.1 COG0652@1|root,COG0652@2|Bacteria,4NMKP@976|Bacteroidetes,2G31W@200643|Bacteroidia 976|Bacteroidetes M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_510191_1 1000565.METUNv1_01551 4.83e-238 662.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVA7@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_293500_2 1000565.METUNv1_02240 9.34e-154 441.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VH25@28216|Betaproteobacteria,2KUQ7@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_400252_1 159087.Daro_0648 4.8e-36 125.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KWBK@206389|Rhodocyclales 206389|Rhodocyclales O redox protein, regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC k59_400252_2 76114.ebA942 2.72e-34 123.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,2VQRE@28216|Betaproteobacteria,2KUDE@206389|Rhodocyclales 206389|Rhodocyclales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_611179_1 1000565.METUNv1_00425 6.32e-10 57.8 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,2KVNK@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_611179_2 1000565.METUNv1_00426 1.98e-117 338.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,2VH0C@28216|Betaproteobacteria,2KUIH@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_510197_1 1000565.METUNv1_00395 1.54e-262 722.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,2KUZS@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_471041_2 1000565.METUNv1_03991 0.0 941.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1111957_1 159450.NH14_30405 3.93e-215 610.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1K4CC@119060|Burkholderiaceae 28216|Betaproteobacteria I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_792594_1 1003200.AXXA_23500 1.88e-06 56.6 COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,2VN4Y@28216|Betaproteobacteria,3T367@506|Alcaligenaceae 28216|Betaproteobacteria L RecF RecN SMC N terminal domain-containing protein - - - - - - - - - - - - AAA_23,AAA_27 k59_471045_1 1000565.METUNv1_00846 1.31e-102 303.0 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,2KVYJ@206389|Rhodocyclales 206389|Rhodocyclales L May be involved in recombination rdgC - - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_576586_1 1000565.METUNv1_03313 4.26e-146 426.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,2KUXG@206389|Rhodocyclales 206389|Rhodocyclales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_188838_1 1000565.METUNv1_03998 5.4e-260 721.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VJS8@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_364426_1 1158294.JOMI01000008_gene16 1.17e-11 60.8 2E4EA@1|root,333UA@2|Bacteria,4NVHU@976|Bacteroidetes,2G2HU@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1050723_1 365046.Rta_34540 6.33e-101 302.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,4AAQ5@80864|Comamonadaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_940067_1 357808.RoseRS_1485 3.28e-42 157.0 COG0366@1|root,COG0366@2|Bacteria,2G7SV@200795|Chloroflexi 200795|Chloroflexi G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase k59_157313_1 929703.KE386491_gene2254 2.3e-42 143.0 COG1225@1|root,COG1225@2|Bacteria,4NNHI@976|Bacteroidetes,47PTD@768503|Cytophagia 976|Bacteroidetes O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_157313_2 1121904.ARBP01000010_gene2408 5.48e-33 120.0 COG0164@1|root,COG0164@2|Bacteria,4NGVR@976|Bacteroidetes,47KXS@768503|Cytophagia 976|Bacteroidetes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_157325_1 1122951.ATUE01000005_gene2228 1.38e-107 330.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3NIGW@468|Moraxellaceae 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_225231_1 1177181.T9A_01718 1.32e-19 93.6 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,1XIPK@135619|Oceanospirillales 135619|Oceanospirillales M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_522915_1 1000565.METUNv1_01403 4.76e-94 292.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,2KU79@206389|Rhodocyclales 206389|Rhodocyclales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_86207_2 1000565.METUNv1_03382 1.54e-255 714.0 2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria,2KVGT@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_86207_3 95619.PM1_0202990 1.32e-35 125.0 COG4315@1|root,COG4315@2|Bacteria,1MZC6@1224|Proteobacteria,1SJ36@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - Lipoprotein_15 k59_479780_1 1000565.METUNv1_00937 1.03e-134 389.0 COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,2KVPE@206389|Rhodocyclales 206389|Rhodocyclales P Bacterial extracellular solute-binding protein cysP - - ko:K02048 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - SBP_bac_11 k59_907698_1 936053.I1BJX4 1.36e-35 139.0 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_836604_1 1163408.UU9_05209 4.31e-57 187.0 COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,1RRBB@1236|Gammaproteobacteria,1X52I@135614|Xanthomonadales 135614|Xanthomonadales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_836604_2 395494.Galf_1023 0.000489 44.7 COG0840@1|root,COG3829@1|root,COG0840@2|Bacteria,COG3829@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria 28216|Betaproteobacteria NT chemotaxis tsr - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,HAMP,MCPsignal,PAS,PAS_8,PAS_9,TarH,dCache_1,sCache_2 k59_452974_1 1123514.KB905901_gene89 5.52e-53 176.0 COG4567@1|root,COG4567@2|Bacteria,1NYHM@1224|Proteobacteria 1224|Proteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg k59_1090916_1 292415.Tbd_1366 5.27e-48 173.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2W14J@28216|Betaproteobacteria 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_202392_1 640081.Dsui_0697 8.76e-43 160.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KW95@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_345220_1 697282.Mettu_1727 1.39e-41 158.0 COG0457@1|root,COG0642@1|root,COG2202@1|root,COG3437@1|root,COG0457@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,1RRGT@1236|Gammaproteobacteria,1XGYT@135618|Methylococcales 135618|Methylococcales T Response regulator receiver - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_549781_1 1000565.METUNv1_02376 8.71e-132 384.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KUN4@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_479828_1 1000565.METUNv1_00477 5.01e-41 154.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KY21@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Response_reg k59_1119740_1 757424.Hsero_2409 2.75e-08 54.7 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,2VKDH@28216|Betaproteobacteria,475F7@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_303113_2 1000565.METUNv1_00404 4.25e-98 288.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,2KWAR@206389|Rhodocyclales 206389|Rhodocyclales L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1014871_1 159087.Daro_0449 5.92e-74 226.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,2KW4U@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_374073_1 946483.Cenrod_1069 6.49e-06 51.2 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9,SBP_bac_3 k59_583398_1 338969.Rfer_2130 4.78e-116 341.0 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2VHVN@28216|Betaproteobacteria,4AAK4@80864|Comamonadaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component dppC2 - - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_583398_2 62928.azo0221 4.82e-05 45.4 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,2KVAJ@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily dppD - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_158067_1 1163617.SCD_n00570 2.24e-16 78.2 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type II secretion system pilC2 - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_158067_2 580332.Slit_0683 3.57e-19 90.1 2CG4C@1|root,2Z8MQ@2|Bacteria,1R6PQ@1224|Proteobacteria,2VHKG@28216|Betaproteobacteria,44WGT@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_940671_1 1247649.D560_3752 7.11e-30 115.0 COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,2VNQ2@28216|Betaproteobacteria,3T9IP@506|Alcaligenaceae 28216|Betaproteobacteria M HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_940671_2 296591.Bpro_3453 3.18e-47 160.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,4AJWS@80864|Comamonadaceae 28216|Betaproteobacteria V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1014882_1 1538295.JY96_18280 1.04e-89 283.0 COG1404@1|root,COG3866@1|root,COG1404@2|Bacteria,COG3866@2|Bacteria,1RFAV@1224|Proteobacteria,2W9R2@28216|Betaproteobacteria,1KN7Q@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix k59_407163_1 911045.PSE_p0301 0.000613 45.4 COG3209@1|root,COG3209@2|Bacteria,1NBF7@1224|Proteobacteria,2UIVP@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566 k59_51340_1 1499967.BAYZ01000185_gene4530 5.6e-42 159.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 k59_617624_1 1095769.CAHF01000022_gene341 1.13e-27 115.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_871611_1 987059.RBXJA2T_14561 7.29e-87 276.0 COG0427@1|root,COG0427@2|Bacteria,1PX5H@1224|Proteobacteria,2W10N@28216|Betaproteobacteria,1KN6G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C k59_1119777_1 1198452.Jab_2c04710 1.34e-20 92.8 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472V1@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase cph2_3 - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,PAS_4 k59_907769_1 1000565.METUNv1_03820 1.01e-104 328.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales 206389|Rhodocyclales P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_667500_1 358220.C380_20970 5.15e-07 50.4 COG3434@1|root,COG3434@2|Bacteria,1R7PA@1224|Proteobacteria,2VPD4@28216|Betaproteobacteria,4ACZ8@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD k59_667500_2 535289.Dtpsy_3111 9.27e-34 130.0 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,2VM4I@28216|Betaproteobacteria,4AAE6@80864|Comamonadaceae 28216|Betaproteobacteria N TIGRFAM Flagellar hook-associated protein 3 flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_453105_1 95619.PM1_0218545 6.34e-56 196.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_266200_1 1003200.AXXA_05158 2.44e-29 113.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VMNH@28216|Betaproteobacteria,3T90Z@506|Alcaligenaceae 28216|Betaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein aphA1 - - - - - - - - - - - Hist_deacetyl k59_549856_1 266264.Rmet_2600 6.35e-15 75.1 COG1414@1|root,COG1414@2|Bacteria,1MYP0@1224|Proteobacteria,2VQQA@28216|Betaproteobacteria,1K3EZ@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_549856_2 1157708.KB907454_gene3021 1.04e-41 147.0 COG1960@1|root,COG1960@2|Bacteria,1Q5ZF@1224|Proteobacteria,2VJHY@28216|Betaproteobacteria,4ADVH@80864|Comamonadaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_158101_2 159087.Daro_3879 2.4e-12 66.6 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,2KUF0@206389|Rhodocyclales 206389|Rhodocyclales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_977201_1 1000565.METUNv1_00271 1.89e-172 504.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria,2KW6S@206389|Rhodocyclales 206389|Rhodocyclales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_940701_1 468059.AUHA01000002_gene555 1.15e-46 157.0 293VW@1|root,2ZRB2@2|Bacteria,4NMK7@976|Bacteroidetes,1ISN4@117747|Sphingobacteriia 976|Bacteroidetes S TIGRFAM gliding motility-associated lipoprotein GldD gldD - - - - - - - - - - - - k59_940701_2 1121405.dsmv_2891 1.07e-07 53.5 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2MK10@213118|Desulfobacterales 28221|Deltaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_617644_1 1502852.FG94_04466 1.5e-58 195.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_801971_1 1122951.ATUE01000008_gene95 1.42e-79 239.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,3NJTK@468|Moraxellaceae 1236|Gammaproteobacteria K Transcriptional regulator iscR GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_1090976_1 500640.CIT292_08808 0.00011 42.0 2AHMX@1|root,317ZV@2|Bacteria,1PZIR@1224|Proteobacteria,1SU9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1014927_1 887062.HGR_15789 3.18e-117 350.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,4AB1S@80864|Comamonadaceae 28216|Betaproteobacteria E gamma-glutamyltransferase ggt1 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_691846_1 388051.AUFE01000052_gene286 3.8e-27 107.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,1K0QB@119060|Burkholderiaceae 28216|Betaproteobacteria K GntR family frlR - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_617651_1 1122621.ATZA01000010_gene167 1.37e-80 256.0 COG0770@1|root,COG0770@2|Bacteria,4NDWD@976|Bacteroidetes,1IQA5@117747|Sphingobacteriia 976|Bacteroidetes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_762347_1 1054213.HMPREF9946_00658 1.05e-67 217.0 COG0300@1|root,COG0300@2|Bacteria,1QU2C@1224|Proteobacteria,2TX5A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_86330_1 351348.Maqu_0995 2.32e-65 209.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_617653_1 1166018.FAES_2088 1.21e-70 233.0 COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,47KP4@768503|Cytophagia 976|Bacteroidetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_940719_1 983544.Lacal_2791 8.19e-05 45.8 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1HX9X@117743|Flavobacteriia 976|Bacteroidetes N Gliding motility protein GldG gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_940719_2 1408473.JHXO01000011_gene3063 7.52e-30 119.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,2FQ8Z@200643|Bacteroidia 976|Bacteroidetes N ABC-type uncharacterized transport system gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_549912_1 365044.Pnap_1608 8.42e-36 127.0 2F4QE@1|root,33XDG@2|Bacteria,1NW4U@1224|Proteobacteria,2W2J6@28216|Betaproteobacteria,4AHX9@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_479952_1 1217658.F987_02006 3.65e-27 113.0 COG2207@1|root,COG2207@2|Bacteria,1RIUK@1224|Proteobacteria,1S7V5@1236|Gammaproteobacteria,3NT3G@468|Moraxellaceae 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_667579_1 649349.Lbys_3496 4.55e-28 108.0 2AE6H@1|root,3140B@2|Bacteria,4NSDV@976|Bacteroidetes,47RV6@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_940730_1 94122.Shewana3_4016 5.29e-54 192.0 COG0642@1|root,COG2202@1|root,COG3614@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QACP@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg,dCache_1 k59_345409_1 1000565.METUNv1_03161 1.46e-27 104.0 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,2VW7C@28216|Betaproteobacteria,2KX95@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_345409_2 305700.B447_19729 2.16e-26 109.0 COG3203@1|root,COG3203@2|Bacteria,1Q1XX@1224|Proteobacteria,2VRRG@28216|Betaproteobacteria,2KVVA@206389|Rhodocyclales 206389|Rhodocyclales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_158157_1 1535422.ND16A_2986 1.18e-53 189.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QWC6@1224|Proteobacteria,1RPDJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein hyfA - - ko:K12136 - - - - ko00000,ko01000 - - iEcolC_1368.EcolC_1195,iUMNK88_1353.UMNK88_3076 Fer4,Fer4_3,Fer4_4,Fer4_6,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3,cNMP_binding k59_1052123_1 614083.AWQR01000005_gene1233 9.84e-110 345.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_802018_1 358220.C380_01130 7.74e-79 241.0 COG1309@1|root,COG1309@2|Bacteria,1R5SG@1224|Proteobacteria,2VNT5@28216|Betaproteobacteria,4ABGC@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein TetR - - - ko:K22294 - - - - ko00000,ko03000 - - - TetR_N k59_940733_1 411902.CLOBOL_06322 4.71e-12 63.9 2DNK9@1|root,32XXG@2|Bacteria,1V9Y9@1239|Firmicutes,24JHZ@186801|Clostridia,2227U@1506553|Lachnoclostridium 186801|Clostridia S Phage protein (N4 Gp49/phage Sf6 gene 66) family - - - - - - - - - - - - Phage_gp49_66 k59_940733_2 194699.Q775A5_BPBPP 2.81e-21 88.2 4QBNJ@10239|Viruses,4QWE0@35237|dsDNA viruses no RNA stage,4QQAU@28883|Caudovirales,4QNSD@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF2815) - - - - - - - - - - - - - k59_453196_1 1116375.VEJY3_11610 6.89e-12 63.5 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1XWX6@135623|Vibrionales 135623|Vibrionales N Flagellar protein FliS fliS GO:0003674,GO:0005198 - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_667593_1 1094466.KQS_02310 3.23e-42 155.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia,2NU0J@237|Flavobacterium 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_667593_2 1094466.KQS_02315 2.77e-10 58.2 COG0221@1|root,COG0221@2|Bacteria,4NGBU@976|Bacteroidetes,1HX3R@117743|Flavobacteriia,2NTT9@237|Flavobacterium 976|Bacteroidetes C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_977250_1 1279017.AQYJ01000029_gene3707 9.28e-29 111.0 COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,1S64S@1236|Gammaproteobacteria,46803@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF934 k59_977250_2 1122951.ATUE01000006_gene1267 2.06e-30 118.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,3NKEQ@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_345420_1 1000565.METUNv1_04024 9.03e-140 410.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,2KUSS@206389|Rhodocyclales 206389|Rhodocyclales L Single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_496504_1 1122951.ATUE01000011_gene486 7.73e-68 206.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,3NNKC@468|Moraxellaceae 1236|Gammaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_952215_1 287.DR97_2972 5.45e-75 229.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1YDAH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_952215_2 1504981.KO116_0381 3.79e-19 85.5 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1XIP5@135619|Oceanospirillales 135619|Oceanospirillales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_814643_1 1184267.A11Q_1752 1.46e-83 262.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2MSMA@213481|Bdellovibrionales,2WKM4@28221|Deltaproteobacteria 213481|Bdellovibrionales C methylmalonate-semialdehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_135892_2 1000565.METUNv1_02239 1.29e-71 227.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKJI@28216|Betaproteobacteria,2KVFT@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_280764_1 760117.JN27_05895 3.24e-40 142.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,473Y2@75682|Oxalobacteraceae 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_852694_1 358220.C380_19735 1.18e-74 231.0 COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2VJ5U@28216|Betaproteobacteria,4AJCK@80864|Comamonadaceae 28216|Betaproteobacteria S EamA-like transporter family rarD - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_28560_1 404380.Gbem_3568 3.88e-85 272.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,42MXU@68525|delta/epsilon subdivisions,2WUC0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L EcoEI R protein C-terminal - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,Helicase_C,ResIII k59_742029_1 348824.LPU83_2023 1.17e-15 80.9 2C22H@1|root,305QB@2|Bacteria,1RFAD@1224|Proteobacteria,2U8GY@28211|Alphaproteobacteria,4BEFE@82115|Rhizobiaceae 28211|Alphaproteobacteria S Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_627923_1 1198452.Jab_2c30030 9.75e-53 176.0 COG1639@1|root,COG1639@2|Bacteria,1R4P9@1224|Proteobacteria,2VPZE@28216|Betaproteobacteria,478PN@75682|Oxalobacteraceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_920115_1 1000565.METUNv1_02624 1.1e-44 146.0 2DTN8@1|root,33M1H@2|Bacteria,1PVKM@1224|Proteobacteria,2VYTX@28216|Betaproteobacteria,2KXJM@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3135) - - - - - - - - - - - - DUF3135 k59_920115_2 1000565.METUNv1_00924 1.53e-40 142.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,2KUAP@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - ko:K13635 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1030176_1 1005048.CFU_3072 2.83e-54 182.0 COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VISE@28216|Betaproteobacteria,474HG@75682|Oxalobacteraceae 28216|Betaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_135953_1 1207076.ALAT01000183_gene3031 4.17e-136 398.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1Z15X@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1030207_1 1144312.PMI09_00567 9.73e-78 239.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2TQPI@28211|Alphaproteobacteria,4BB7T@82115|Rhizobiaceae 28211|Alphaproteobacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1030207_2 1163617.SCD_n02911 2.11e-86 259.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,2VQ02@28216|Betaproteobacteria 28216|Betaproteobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_496685_1 742817.HMPREF9449_01999 3.67e-124 362.0 COG2025@1|root,COG2025@2|Bacteria,4NFSE@976|Bacteroidetes,2FMEK@200643|Bacteroidia,22W4A@171551|Porphyromonadaceae 976|Bacteroidetes C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_952318_1 795666.MW7_1594 7.95e-51 171.0 COG1974@1|root,COG1974@2|Bacteria,1PTZE@1224|Proteobacteria,2VV6A@28216|Betaproteobacteria,1K89A@119060|Burkholderiaceae 28216|Betaproteobacteria KT Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_742106_1 614083.AWQR01000014_gene2464 1.45e-22 92.0 COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2VIQH@28216|Betaproteobacteria,4ACY5@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short k59_742106_2 614083.AWQR01000014_gene2466 3.61e-33 121.0 COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,2VRS9@28216|Betaproteobacteria,4ADMR@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_496690_2 648757.Rvan_3436 1.75e-10 59.7 2E633@1|root,330S6@2|Bacteria,1NDGF@1224|Proteobacteria,2UG8W@28211|Alphaproteobacteria,3N98K@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_496690_3 1187851.A33M_1276 1.46e-27 101.0 COG5554@1|root,COG5554@2|Bacteria,1N7DQ@1224|Proteobacteria,2UF73@28211|Alphaproteobacteria,3FDHZ@34008|Rhodovulum 28211|Alphaproteobacteria Q NifT/FixU protein fixU - - ko:K02593 - - - - ko00000 - - - NifT k59_238911_1 1500893.JQNB01000001_gene3316 5.01e-65 209.0 COG3000@1|root,COG3000@2|Bacteria,1R763@1224|Proteobacteria,1S0C8@1236|Gammaproteobacteria,1X5RH@135614|Xanthomonadales 135614|Xanthomonadales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_854231_1 1395516.PMO01_14735 4.9e-29 120.0 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,1RNRK@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Large exoproteins involved in heme utilization or adhesion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Fil_haemagg,Fil_haemagg_2,Haemagg_act k59_238944_1 1121035.AUCH01000020_gene2686 1.37e-91 285.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KV2C@206389|Rhodocyclales 206389|Rhodocyclales NT COG0643 Chemotaxis protein histidine kinase and related kinases - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_498317_1 614083.AWQR01000006_gene263 8.22e-132 379.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,4AB1F@80864|Comamonadaceae 28216|Betaproteobacteria P CBS domain containing protein corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_29893_1 1301098.PKB_4565 2.77e-49 163.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component mlaE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_706683_1 1000565.METUNv1_02684 9.66e-103 306.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KW8Q@206389|Rhodocyclales 206389|Rhodocyclales S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_173918_1 1121035.AUCH01000019_gene2850 3.82e-131 383.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,2KV2X@206389|Rhodocyclales 206389|Rhodocyclales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_921363_1 1005048.CFU_3559 8.8e-124 377.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,473JT@75682|Oxalobacteraceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_706690_1 1168065.DOK_02186 1.23e-75 238.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1J4CX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_03375 S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_953389_2 391587.KAOT1_04982 3.58e-52 177.0 COG0112@1|root,COG0112@2|Bacteria,4NE30@976|Bacteroidetes,1HXUW@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_854304_1 1276756.AUEX01000007_gene1372 6.06e-98 297.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,4ABF1@80864|Comamonadaceae 28216|Betaproteobacteria S peptidase U62, modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_102774_1 640081.Dsui_0943 2.29e-19 87.8 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,2KV00@206389|Rhodocyclales 206389|Rhodocyclales C Dinitrogenase iron-molybdenum cofactor - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_498403_1 391008.Smal_2904 1.41e-17 88.6 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1X2YV@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_137207_1 1286631.X805_39070 3.14e-44 158.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2VHG5@28216|Betaproteobacteria,1KJV5@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_815943_1 1392490.JHZX01000001_gene746 1.48e-24 100.0 COG3693@1|root,COG3693@2|Bacteria,4NE5Z@976|Bacteroidetes,1HYN4@117743|Flavobacteriia 976|Bacteroidetes G Beta-xylanase - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_10 k59_815943_2 649349.Lbys_2332 2.23e-54 183.0 COG2211@1|root,COG2211@2|Bacteria,4NE3B@976|Bacteroidetes,47NF2@768503|Cytophagia 976|Bacteroidetes G COGs COG2211 Na melibiose symporter and related transporter gph - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_854353_2 880070.Cycma_0644 1.15e-37 138.0 COG0064@1|root,COG0064@2|Bacteria,4NF3B@976|Bacteroidetes,47K7E@768503|Cytophagia 976|Bacteroidetes J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_953439_1 614083.AWQR01000039_gene1452 1.08e-94 286.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,4AAGS@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_706762_1 296591.Bpro_2290 1.79e-28 112.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,4AB55@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_921448_1 1279009.ADICEAN_00260 3.1e-20 92.0 COG1835@1|root,COG1835@2|Bacteria,4NPI2@976|Bacteroidetes,47JPN@768503|Cytophagia 976|Bacteroidetes I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_889854_1 96561.Dole_0042 2.45e-43 152.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,2MHRN@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_889854_2 66377.JOBH01000006_gene319 1.42e-11 62.0 COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria 201174|Actinobacteria O Belongs to the glutathione peroxidase family btuE - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_102844_1 595537.Varpa_0970 6.52e-52 165.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2VRGP@28216|Betaproteobacteria,4ADKY@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_567143_1 925775.XVE_0433 1.4e-08 62.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,1X51R@135614|Xanthomonadales 135614|Xanthomonadales M cellulose synthase bcsB - - ko:K20541 - - - - ko00000,ko02000 4.D.3.1.6 - - BcsB k59_30028_1 614083.AWQR01000001_gene3030 3.28e-86 262.0 COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,2VI7P@28216|Betaproteobacteria,4A9NX@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluF - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_992155_1 232237.Q7Y5F9_9CAUD 8.69e-20 85.5 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_1134667_1 614083.AWQR01000034_gene3564 7.33e-23 97.4 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,4AAF6@80864|Comamonadaceae 28216|Betaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_706798_1 1268622.AVS7_03776 5.73e-60 187.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,4AEEA@80864|Comamonadaceae 28216|Betaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_628920_1 1304883.KI912532_gene259 2.18e-86 262.0 COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,2WHDA@28216|Betaproteobacteria,2KXUH@206389|Rhodocyclales 206389|Rhodocyclales I Alpha/beta hydrolase of unknown function (DUF915) - - - - - - - - - - - - - k59_282102_1 864051.BurJ1DRAFT_0453 7.03e-33 127.0 COG0470@1|root,COG0470@2|Bacteria,1MVEE@1224|Proteobacteria,2VP7K@28216|Betaproteobacteria,1KKMZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DNA polymerase III - - - - - - - - - - - - - k59_282102_2 218491.ECA2874 2.4e-58 189.0 28MTH@1|root,2ZB1P@2|Bacteria,1R6K1@1224|Proteobacteria,1S3MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF4007) - - - - - - - - - - - - DUF4007 k59_1134687_2 338969.Rfer_0769 1.75e-28 116.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,4ACZ5@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM glycosyl transferase family 39 arnT - - - - - - - - - - - PMT_2 k59_921497_2 338969.Rfer_2626 5.42e-16 71.6 2E3H4@1|root,32YFT@2|Bacteria,1N8PU@1224|Proteobacteria,2VVRT@28216|Betaproteobacteria,4AFD1@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - ZapB k59_498532_1 640510.BC1001_3406 1.03e-30 124.0 28I2U@1|root,2Z86S@2|Bacteria,1P33F@1224|Proteobacteria,2VP36@28216|Betaproteobacteria,1K0WX@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3443) - - - - - - - - - - - - DUF3443 k59_854469_2 640512.BC1003_1976 2.92e-77 245.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VJZG@28216|Betaproteobacteria,1K349@119060|Burkholderiaceae 28216|Betaproteobacteria U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_854478_1 946077.W5A_06500 7.25e-53 174.0 COG2103@1|root,COG2103@2|Bacteria,4NEPY@976|Bacteroidetes,1HXU4@117743|Flavobacteriia 976|Bacteroidetes G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS k59_137320_1 1121920.AUAU01000007_gene507 6.72e-91 282.0 COG3227@1|root,COG3227@2|Bacteria 2|Bacteria E Zinc metalloprotease (Elastase) - - 3.4.24.27 ko:K08603,ko:K20273 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - FTP,PepSY,Peptidase_M4,Peptidase_M4_C k59_854495_1 1123508.JH636450_gene7211 4.4e-41 154.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,2IXFD@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_743982_1 414684.RC1_1750 1.42e-21 91.3 2A16B@1|root,30PCB@2|Bacteria,1Q29I@1224|Proteobacteria,2V9PI@28211|Alphaproteobacteria,2JU5S@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - FliJ k59_854502_1 323850.Shew_0485 2.1e-17 77.8 COG1278@1|root,COG1278@2|Bacteria,1N1M6@1224|Proteobacteria,1S9AQ@1236|Gammaproteobacteria,2QBXI@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM Cold-shock protein, DNA-binding - - - - - - - - - - - - CSD,Excalibur k59_854502_2 1000565.METUNv1_03580 1.67e-59 194.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2W9R7@28216|Betaproteobacteria,2KZDB@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_30085_1 987059.RBXJA2T_05873 1.89e-40 144.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,1KKN7@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_647231_1 1000565.METUNv1_00123 2.18e-155 442.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KVK1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_647231_2 1000565.METUNv1_00124 5.23e-71 216.0 2CJFN@1|root,32ZIB@2|Bacteria,1N7QI@1224|Proteobacteria,2VX2C@28216|Betaproteobacteria,2KX8A@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_182983_1 1000565.METUNv1_02153 3.03e-178 531.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KYID@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_789016_1 1121033.AUCF01000044_gene4582 1.27e-50 174.0 COG1344@1|root,COG1344@2|Bacteria,1MXC4@1224|Proteobacteria,2TRIP@28211|Alphaproteobacteria,2JTNX@204441|Rhodospirillales 204441|Rhodospirillales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - - - - - - - - - - Flagellin_C,Flagellin_N k59_930592_1 1000565.METUNv1_00072 3.42e-151 437.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,2KXXX@206389|Rhodocyclales 206389|Rhodocyclales C Aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_647248_2 76114.ebA6625 2.39e-08 55.1 28KC1@1|root,2Z9Z1@2|Bacteria,1MW96@1224|Proteobacteria,2VNCU@28216|Betaproteobacteria,2KY2B@206389|Rhodocyclales 206389|Rhodocyclales S Type-1V conjugative transfer system mating pair stabilisation - - - ko:K12058 - - - - ko00000,ko02044 3.A.7.11.1 - - TraN k59_1002429_1 338969.Rfer_2373 1.97e-70 218.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VQUX@28216|Betaproteobacteria,4AB0Y@80864|Comamonadaceae 28216|Betaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_432882_1 1384054.N790_11960 3.87e-176 516.0 COG0657@1|root,COG2072@1|root,COG0657@2|Bacteria,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria,1X6KD@135614|Xanthomonadales 135614|Xanthomonadales IP Flavin-binding monooxygenase-like - - - - - - - - - - - - Abhydrolase_3,FMO-like,Pyr_redox_3 k59_432882_2 323848.Nmul_A0149 6.58e-54 174.0 COG3305@1|root,COG3305@2|Bacteria,1RKBI@1224|Proteobacteria,2WBN8@28216|Betaproteobacteria,374DQ@32003|Nitrosomonadales 28216|Betaproteobacteria S Predicted membrane protein (DUF2127) - - - - - - - - - - - - DUF2127 k59_1038805_1 1000565.METUNv1_00084 6.69e-206 578.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KV3K@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains ntrC - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_74074_1 1267211.KI669560_gene1988 5.37e-117 344.0 COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1INZ7@117747|Sphingobacteriia 976|Bacteroidetes I acyl-CoA dehydrogenase gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_752438_1 1000565.METUNv1_02753 1.78e-12 66.6 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,2VIUT@28216|Betaproteobacteria,2KUKV@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_752438_2 1000565.METUNv1_02752 1.53e-135 395.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,2KU7R@206389|Rhodocyclales 206389|Rhodocyclales DM COG0739 Membrane proteins related to metalloendopeptidases - - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_752438_4 1121035.AUCH01000001_gene1983 3.07e-33 121.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,2KU8F@206389|Rhodocyclales 206389|Rhodocyclales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_789030_2 1144325.PMI22_00480 1.03e-27 114.0 COG0741@1|root,COG0741@2|Bacteria,1R43Q@1224|Proteobacteria,1RPI2@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - PG_binding_1,SLT k59_1109347_1 1000565.METUNv1_03897 1.86e-119 358.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,2KV5Q@206389|Rhodocyclales 206389|Rhodocyclales M surface antigen (D15) - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA k59_538205_1 269482.Bcep1808_5994 8.68e-237 660.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,1K02B@119060|Burkholderiaceae 28216|Betaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_74085_1 1000565.METUNv1_04063 1.08e-195 564.0 COG4206@1|root,COG4206@2|Bacteria,1QUWU@1224|Proteobacteria,2WGQG@28216|Betaproteobacteria,2KV16@206389|Rhodocyclales 206389|Rhodocyclales H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_824092_1 1000565.METUNv1_03157 1.16e-80 249.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,2KVER@206389|Rhodocyclales 206389|Rhodocyclales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metX - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_824092_2 1336241.JAEB01000026_gene932 9.71e-13 63.9 COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24NFX@186801|Clostridia 186801|Clostridia S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_859419_1 266117.Rxyl_2440 2.59e-141 407.0 COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria,4CPZF@84995|Rubrobacteria 84995|Rubrobacteria S Acetyl xylan esterase (AXE1) - - - ko:K06889 - - - - ko00000 - - - AXE1 k59_1075634_1 1538295.JY96_08800 6.09e-18 82.0 COG1196@1|root,COG1196@2|Bacteria,1NGZ2@1224|Proteobacteria,2VIWY@28216|Betaproteobacteria 28216|Betaproteobacteria D SMC domain protein - - - - - - - - - - - - AAA_21,AAA_29,SMC_N k59_1075634_2 887062.HGR_12437 1.29e-42 147.0 28KTK@1|root,2ZAAP@2|Bacteria,1RCI8@1224|Proteobacteria,2VQ6W@28216|Betaproteobacteria,4AH5G@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_824100_1 106648.BBLJ01000008_gene510 1.9e-10 60.8 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,3NN5T@468|Moraxellaceae 1236|Gammaproteobacteria U general secretion pathway protein gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_752458_1 261292.Nit79A3_0430 1.82e-48 176.0 COG1216@1|root,COG2120@1|root,COG1216@2|Bacteria,COG2120@2|Bacteria,1MZSD@1224|Proteobacteria,2VUX2@28216|Betaproteobacteria,3736Y@32003|Nitrosomonadales 28216|Betaproteobacteria M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_transf_7C,Glycos_transf_2,PIG-L k59_325904_1 1000565.METUNv1_02975 5.69e-66 220.0 COG1566@1|root,COG1566@2|Bacteria,1QVR9@1224|Proteobacteria,2W3A9@28216|Betaproteobacteria 28216|Betaproteobacteria V Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_4 k59_467473_1 1000565.METUNv1_02120 3.61e-113 340.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,2KVEZ@206389|Rhodocyclales 206389|Rhodocyclales M Outer membrane efflux protein - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_467473_2 497321.C664_10123 7.39e-64 200.0 COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,2KWJR@206389|Rhodocyclales 206389|Rhodocyclales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_74108_2 1245469.S58_61930 2.1e-27 101.0 2EMFD@1|root,33F45@2|Bacteria,1NMV1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_74108_3 287.DR97_4557 2.16e-45 163.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1YFEJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M RHS Repeat - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_896063_1 1000565.METUNv1_02799 3.1e-92 274.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,2KVQS@206389|Rhodocyclales 206389|Rhodocyclales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_896063_2 1000565.METUNv1_02798 5.79e-96 285.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,2KW5P@206389|Rhodocyclales 206389|Rhodocyclales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_39476_1 743299.Acife_1711 5.63e-06 48.1 2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,1SF7K@1236|Gammaproteobacteria,2ND4D@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_39476_2 743722.Sph21_0329 5.67e-59 185.0 COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,1ITFK@117747|Sphingobacteriia 976|Bacteroidetes M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_504466_1 1000565.METUNv1_00569 4.73e-114 342.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,2KVHT@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_966549_1 1392488.JHZY01000004_gene3247 6.68e-19 81.3 COG0590@1|root,COG0590@2|Bacteria,4NNJ2@976|Bacteroidetes,1I17S@117743|Flavobacteriia,2XJ6T@283735|Leeuwenhoekiella 976|Bacteroidetes FJ MafB19-like deaminase tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_966549_2 1469557.JSWF01000012_gene1200 4.76e-54 177.0 COG3358@1|root,COG3358@2|Bacteria,4NNWJ@976|Bacteroidetes,1I20T@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 k59_504476_1 1000565.METUNv1_03791 2.6e-97 292.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,2KV7M@206389|Rhodocyclales 206389|Rhodocyclales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_504476_2 1000565.METUNv1_03790 2.02e-90 276.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,2KV1D@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_325938_1 637389.Acaty_c0097 3.67e-59 188.0 28HUJ@1|root,2Z819@2|Bacteria,1MW8B@1224|Proteobacteria,1S2QX@1236|Gammaproteobacteria,2NDSN@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_718314_1 1000565.METUNv1_00711 6.56e-52 172.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,2KUVW@206389|Rhodocyclales 206389|Rhodocyclales M UDP-glucose 4-epimerase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_718314_3 1000565.METUNv1_00713 1.8e-82 247.0 COG4968@1|root,COG4968@2|Bacteria,1QVCD@1224|Proteobacteria,2WGQ3@28216|Betaproteobacteria,2KWT8@206389|Rhodocyclales 206389|Rhodocyclales U Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_327400_1 375286.mma_0623 6.33e-64 196.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,474GR@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_327405_1 1349767.GJA_2836 1.74e-55 196.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,472QP@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1003540_1 243365.CV_2733 1.38e-49 176.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KPQ3@206351|Neisseriales 206351|Neisseriales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_1003540_2 264198.Reut_A0570 3.32e-43 157.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K044@119060|Burkholderiaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtC - - ko:K03296,ko:K07788,ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_468460_1 614083.AWQR01000021_gene225 3.93e-120 350.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,4A9RQ@80864|Comamonadaceae 28216|Betaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_789985_1 1000565.METUNv1_00477 6.46e-120 367.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KY21@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Response_reg k59_1077218_1 95619.PM1_0217380 4.15e-70 228.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_290507_1 1249627.D779_3612 2e-09 58.2 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator, LysR - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_290507_2 1000565.METUNv1_02371 3.16e-13 68.2 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,2KVF4@206389|Rhodocyclales 1224|Proteobacteria G Fructose-1-6-bisphosphatase, N-terminal domain fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11,3.1.3.37 ko:K01086,ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_1039872_1 1000565.METUNv1_03924 1.42e-32 124.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,2KUZ2@206389|Rhodocyclales 206389|Rhodocyclales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1039872_2 1000565.METUNv1_03925 4.43e-78 237.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KWHT@206389|Rhodocyclales 206389|Rhodocyclales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_860190_1 1000565.METUNv1_02250 6.4e-71 214.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,2KWR4@206389|Rhodocyclales 206389|Rhodocyclales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_75342_1 880071.Fleli_3989 1.17e-36 147.0 COG1361@1|root,COG3291@1|root,COG4886@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,CBM_3,CHU_C,DUF285,Glyco_hydro_9,PKD,Peptidase_M43,VCBS k59_397663_1 1218084.BBJK01000002_gene281 5.16e-63 210.0 COG0028@1|root,COG0028@2|Bacteria,1MXG0@1224|Proteobacteria,2VK74@28216|Betaproteobacteria,1K1TY@119060|Burkholderiaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_967264_1 1123255.JHYS01000004_gene1018 1.82e-60 210.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,4ABCW@80864|Comamonadaceae 28216|Betaproteobacteria T ATP-binding region, ATPase domain protein pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_789991_1 1000565.METUNv1_03786 7.95e-260 716.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,2KUVI@206389|Rhodocyclales 206389|Rhodocyclales M UDP binding domain - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1039885_1 1123367.C666_08955 8.78e-166 478.0 COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,2VNRY@28216|Betaproteobacteria,2KXBD@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262 k59_860200_1 1000565.METUNv1_00635 1.2e-12 65.9 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales 206389|Rhodocyclales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_860200_2 1000565.METUNv1_00636 1.57e-153 433.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,2KV09@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_753195_1 1121935.AQXX01000072_gene3 6.21e-50 182.0 COG1572@1|root,COG2304@1|root,COG3209@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,1QU09@1224|Proteobacteria,1T39R@1236|Gammaproteobacteria 1236|Gammaproteobacteria N Protein involved in outer membrane biogenesis - - - - - - - - - - - - He_PIG,RHS_repeat k59_184596_1 1198452.Jab_2c07840 7.28e-90 271.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,4730V@75682|Oxalobacteraceae 28216|Betaproteobacteria O PFAM 20S proteasome, A and B subunits - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1003566_1 1000565.METUNv1_00571 7.94e-110 327.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,2KUEC@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1003566_2 1000565.METUNv1_00570 1.67e-166 468.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,2KUVF@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_184597_1 362418.IW19_09625 8.68e-06 53.9 2CI9I@1|root,30JUG@2|Bacteria,4NTXT@976|Bacteroidetes,1IKY3@117743|Flavobacteriia,2NXQW@237|Flavobacterium 976|Bacteroidetes S Protein of unknown function (DUF2931) - - - - - - - - - - - - DUF2931 k59_361694_1 483216.BACEGG_00712 5.97e-07 53.1 COG2972@1|root,COG2972@2|Bacteria,4NFDP@976|Bacteroidetes,2FPUC@200643|Bacteroidia,4AN73@815|Bacteroidaceae 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase k59_40548_1 614083.AWQR01000014_gene2434 9.25e-61 194.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,4AAAK@80864|Comamonadaceae 28216|Betaproteobacteria E HAD-superfamily hydrolase, subfamily IB, PSPase-like - - - - - - - - - - - - HAD k59_753201_2 1000565.METUNv1_03456 2.28e-47 164.0 COG0515@1|root,COG0589@1|root,COG0515@2|Bacteria,COG0589@2|Bacteria,1MV1P@1224|Proteobacteria,2VM52@28216|Betaproteobacteria,2KYMH@206389|Rhodocyclales 206389|Rhodocyclales KLT Universal stress protein family - - - - - - - - - - - - Pkinase,Usp k59_681721_1 1215092.PA6_018_00150 2.11e-16 80.5 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1YIZ1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 k59_681721_2 1000565.METUNv1_00478 1.45e-25 106.0 COG2911@1|root,COG2911@2|Bacteria,1QWGG@1224|Proteobacteria,2WGYX@28216|Betaproteobacteria,2KZX3@206389|Rhodocyclales 206389|Rhodocyclales S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_1003581_1 398578.Daci_4753 1.59e-29 124.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,4AECM@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM AMP-dependent synthetase and ligase - - - ko:K04784 ko01053,map01053 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_648951_1 666681.M301_1784 1.27e-119 352.0 COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2VQE7@28216|Betaproteobacteria,2KNG3@206350|Nitrosomonadales 206350|Nitrosomonadales S PFAM alpha beta hydrolase fold - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Hydrolase_4 k59_897211_1 1000565.METUNv1_02843 2.12e-63 202.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,2KVI6@206389|Rhodocyclales 206389|Rhodocyclales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_897211_2 1286631.X805_19730 2.54e-43 157.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2VIWG@28216|Betaproteobacteria,1KJRG@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_1039922_1 365044.Pnap_4588 3.89e-163 508.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE k59_369058_1 614083.AWQR01000006_gene346 2.81e-17 75.5 COG0662@1|root,COG0662@2|Bacteria,1QVI4@1224|Proteobacteria,2WGS5@28216|Betaproteobacteria,4AJXG@80864|Comamonadaceae 28216|Betaproteobacteria G Mannose-6-phosphate isomerase - - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer k59_369058_2 1192868.CAIU01000029_gene3892 2.64e-29 110.0 COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2TUCZ@28211|Alphaproteobacteria,43GSM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G ABC-type sugar transport system periplasmic component - - - ko:K17315 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - SBP_bac_1 k59_904004_1 1353529.M899_1996 2.67e-35 129.0 COG3897@1|root,COG3897@2|Bacteria,1MUWA@1224|Proteobacteria,42NV1@68525|delta/epsilon subdivisions,2WJZ9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Lysine methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_16,PrmA k59_369059_1 1000565.METUNv1_01184 7.89e-159 455.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,2KU64@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_544998_1 864051.BurJ1DRAFT_0943 1.06e-53 196.0 COG2374@1|root,COG4625@1|root,COG2374@2|Bacteria,COG4625@2|Bacteria,1MX52@1224|Proteobacteria,2VK7U@28216|Betaproteobacteria,1KK7E@119065|unclassified Burkholderiales 28216|Betaproteobacteria S endonuclease exonuclease phosphatase - - - ko:K07004 - - - - ko00000 - - - Exo_endo_phos,LTD k59_937061_1 1000565.METUNv1_00411 4.11e-199 561.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,2KVFJ@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_195430_1 85643.Tmz1t_3162 5.22e-65 225.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria 28216|Betaproteobacteria L Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - AAA_29,SbcCD_C k59_758521_1 498211.CJA_2218 6.57e-42 147.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1FGQK@10|Cellvibrio 1236|Gammaproteobacteria K Sigma-70 factor, region 1.2 rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_261413_1 1000565.METUNv1_01868 1.02e-118 355.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,2KUNY@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_832600_2 396588.Tgr7_2175 0.000128 48.1 COG0790@1|root,COG0790@2|Bacteria,1PFSC@1224|Proteobacteria,1TJ65@1236|Gammaproteobacteria,1WY15@135613|Chromatiales 135613|Chromatiales S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_1010887_1 1415630.U771_13900 4.51e-64 217.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_46943_1 614083.AWQR01000005_gene1246 2.66e-106 322.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,4A9MZ@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_579851_1 575540.Isop_0693 2.72e-19 86.7 COG0714@1|root,COG0714@2|Bacteria,2IYBI@203682|Planctomycetes 203682|Planctomycetes S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_475143_1 1000565.METUNv1_03652 6.64e-109 316.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,2KW7R@206389|Rhodocyclales 206389|Rhodocyclales H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_758532_1 365046.Rta_34510 9.91e-17 79.7 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9WN@80864|Comamonadaceae 28216|Betaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_758532_2 1157708.KB907459_gene2059 3.53e-58 185.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,4ADJC@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM N-acetylmuramoyl-L-alanine amidase family 2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_1045484_1 1120966.AUBU01000002_gene2362 2.51e-10 66.2 COG3291@1|root,COG3291@2|Bacteria,4NIBR@976|Bacteroidetes,47NDA@768503|Cytophagia 976|Bacteroidetes S PKD domain - - - - - - - - - - - - CHU_C,PKD k59_403560_1 1121897.AUGO01000004_gene896 3.4e-09 58.2 COG1216@1|root,COG1216@2|Bacteria,4PKUM@976|Bacteroidetes,1IJFR@117743|Flavobacteriia,2P0UW@237|Flavobacterium 976|Bacteroidetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_937078_1 1000565.METUNv1_00450 3.55e-82 250.0 COG2197@1|root,COG2197@2|Bacteria,1N4IH@1224|Proteobacteria,2VU70@28216|Betaproteobacteria,2KXGI@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_338054_1 551789.ATVJ01000002_gene3123 9.42e-16 82.8 COG3307@1|root,COG3307@2|Bacteria,1R5EX@1224|Proteobacteria,2TTQF@28211|Alphaproteobacteria,43WCA@69657|Hyphomonadaceae 28211|Alphaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_972757_1 468059.AUHA01000003_gene1567 3.9e-39 138.0 COG1309@1|root,COG1309@2|Bacteria,4NQ99@976|Bacteroidetes,1ISRH@117747|Sphingobacteriia 976|Bacteroidetes K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_724251_2 1000565.METUNv1_00662 1.54e-187 528.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2VI2X@28216|Betaproteobacteria,2KVMX@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_904043_1 1189620.AJXL01000022_gene2878 1.31e-06 51.2 COG0784@1|root,COG3290@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,1IKKI@117743|Flavobacteriia,2P0QX@237|Flavobacterium 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg k59_904043_2 1057002.KB905370_gene3448 5.29e-38 136.0 COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2TUTF@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Senescence marker protein-30 family protein - - - ko:K14274 ko00040,map00040 - R02427 RC00713 ko00000,ko00001,ko01000 - - - SGL k59_866823_1 1000565.METUNv1_00478 5.06e-110 348.0 COG2911@1|root,COG2911@2|Bacteria,1QWGG@1224|Proteobacteria,2WGYX@28216|Betaproteobacteria,2KZX3@206389|Rhodocyclales 206389|Rhodocyclales S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_298050_1 679191.HMPREF9018_0095 1.17e-15 83.2 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FMH3@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_10545_1 1000565.METUNv1_04025 1.14e-95 287.0 COG4255@1|root,COG4255@2|Bacteria,1R59K@1224|Proteobacteria,2VKW9@28216|Betaproteobacteria,2KVHV@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - - - - - - - - - - PhosphMutase k59_338075_1 1000565.METUNv1_03791 1.86e-15 74.7 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,2KV7M@206389|Rhodocyclales 206389|Rhodocyclales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_338075_2 1122185.N792_03085 3.81e-26 105.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales 135614|Xanthomonadales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_338078_1 1071679.BG57_28140 8.22e-55 184.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1K1I5@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_660307_1 1000565.METUNv1_00989 7.17e-115 339.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,2KUGI@206389|Rhodocyclales 206389|Rhodocyclales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - - - - - - - - - - NMT1_2 k59_195502_1 1100720.ALKN01000024_gene1553 7.4e-140 404.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_516862_1 1408164.MOLA814_02439 5.06e-14 69.3 COG0450@1|root,COG0450@2|Bacteria,1QWIV@1224|Proteobacteria,2WHWS@28216|Betaproteobacteria 28216|Betaproteobacteria O Redoxin - - - - - - - - - - - - AhpC-TSA k59_516862_2 580332.Slit_0297 2.32e-47 158.0 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2VQ90@28216|Betaproteobacteria,44W5P@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM Methyltransferase type 12 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_369141_2 1121912.AUHD01000018_gene3448 2.04e-10 62.8 COG2885@1|root,COG2885@2|Bacteria,4NNT0@976|Bacteroidetes,1I214@117743|Flavobacteriia 976|Bacteroidetes M OmpA family - - - - - - - - - - - - OmpA k59_545067_1 1000565.METUNv1_03520 7.28e-88 278.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,2VMV8@28216|Betaproteobacteria,2KVSP@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_545067_2 1000565.METUNv1_03519 2.4e-72 218.0 COG1846@1|root,COG1846@2|Bacteria,1N0TY@1224|Proteobacteria,2VV7T@28216|Betaproteobacteria,2KZMT@206389|Rhodocyclales 206389|Rhodocyclales K MarR family - - - - - - - - - - - - HTH_24 k59_614121_1 1211112.ALJC01000093_gene1367 6.08e-48 171.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_445994_1 864073.HFRIS_019823 2.7e-101 302.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,472AM@75682|Oxalobacteraceae 28216|Betaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_46992_1 296591.Bpro_3291 2.77e-96 286.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,4AAY0@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM Serine O-acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_46992_2 1100720.ALKN01000007_gene2957 3.64e-20 87.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2VI2D@28216|Betaproteobacteria,4AB0R@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_403600_1 1000565.METUNv1_02538 2.22e-54 175.0 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales 206389|Rhodocyclales S FixH family - - - ko:K09926 - - - - ko00000 - - - FixH k59_797243_1 313606.M23134_01726 1.6e-15 82.4 COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40 k59_261494_1 172088.AUGA01000002_gene5774 1.32e-22 105.0 COG5545@1|root,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria,3JWBU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Virulence-associated protein E - - - - - - - - - - - - Prim-Pol,Toprim_3,VirE k59_516913_1 454957.IA64_08190 1.35e-73 231.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1X3CD@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_10594_1 397945.Aave_4772 8.6e-72 227.0 COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,2VQKH@28216|Betaproteobacteria,4AG3S@80864|Comamonadaceae 28216|Betaproteobacteria K helix-turn-helix- domain containing protein, AraC type eutR - - ko:K04033 - - - - ko00000,ko03000 - - - HTH_18 k59_1010950_1 211165.AJLN01000116_gene3529 1.94e-47 173.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_403616_1 1454004.AW11_01373 2.15e-27 106.0 COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,2VR6V@28216|Betaproteobacteria 28216|Betaproteobacteria N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly flgA - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_338142_1 1198452.Jab_2c24540 1.2e-102 306.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,473CZ@75682|Oxalobacteraceae 28216|Betaproteobacteria O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_832670_1 1123377.AUIV01000007_gene1269 7.55e-34 134.0 COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,1R3YH@1224|Proteobacteria,1RX87@1236|Gammaproteobacteria,1X5U4@135614|Xanthomonadales 135614|Xanthomonadales KT Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - Peptidase_M56,TonB_C k59_475231_2 1120977.JHUX01000005_gene2827 1.88e-103 307.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,3NJ5K@468|Moraxellaceae 1236|Gammaproteobacteria Q ATPases associated with a variety of cellular activities mlaF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_758607_1 1305737.JAFX01000001_gene2731 1.77e-53 171.0 COG1764@1|root,COG1764@2|Bacteria,4NQKB@976|Bacteroidetes,47QKW@768503|Cytophagia 976|Bacteroidetes O OsmC-like protein - - - ko:K04063 - - - - ko00000 - - - OsmC k59_866909_2 1000565.METUNv1_01273 2.64e-68 213.0 COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,2KW4N@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_195598_2 1121106.JQKB01000016_gene5268 5.34e-26 108.0 COG0500@1|root,COG2520@1|root,COG2226@2|Bacteria,COG2520@2|Bacteria,1RIYU@1224|Proteobacteria,2U2ZF@28211|Alphaproteobacteria,2JSTB@204441|Rhodospirillales 204441|Rhodospirillales Q Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_1045550_1 1000565.METUNv1_03201 4.33e-88 279.0 COG4772@1|root,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,2WGQ6@28216|Betaproteobacteria,2KVN0@206389|Rhodocyclales 206389|Rhodocyclales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_545127_1 1201288.M900_A0098 1.39e-60 200.0 COG3677@1|root,COG3677@2|Bacteria,1NUJD@1224|Proteobacteria,42ZJP@68525|delta/epsilon subdivisions,2MTUZ@213481|Bdellovibrionales,2WUVR@28221|Deltaproteobacteria 213481|Bdellovibrionales L Transposase - - - - - - - - - - - - - k59_660419_1 1000565.METUNv1_02605 1.25e-171 483.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2VHMJ@28216|Betaproteobacteria,2KV8A@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_47040_1 1218084.BBJK01000099_gene6274 1.08e-27 109.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,1K0G7@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily oppD - - ko:K02031,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_47040_2 1071679.BG57_03580 1.17e-85 259.0 COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2VIGP@28216|Betaproteobacteria,1KFGR@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component oppC - - ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k59_195605_1 159087.Daro_3858 1.28e-19 87.0 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,2KVYJ@206389|Rhodocyclales 206389|Rhodocyclales L May be involved in recombination rdgC - - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_195605_2 598467.BrE312_2142 9.35e-45 151.0 2E9IJ@1|root,31606@2|Bacteria,1MY9P@1224|Proteobacteria,1S8MY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_545130_1 1226994.AMZB01000104_gene1408 2.81e-07 57.4 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YCZY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - 2.7.13.3 ko:K02030,ko:K07679 ko02020,ko05133,map02020,map05133 M00236,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - CHASE,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_545130_2 365044.Pnap_3754 1.85e-28 108.0 COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2VSFP@28216|Betaproteobacteria,4ADVG@80864|Comamonadaceae 28216|Betaproteobacteria C nitroreductase aoxC - - - - - - - - - - - Nitroreductase k59_546165_1 1000565.METUNv1_01100 1.06e-119 349.0 COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2VJ5J@28216|Betaproteobacteria,2KY45@206389|Rhodocyclales 206389|Rhodocyclales P NMT1-like family - - - - - - - - - - - - NMT1 k59_759453_1 765420.OSCT_1052 1.62e-50 176.0 COG0504@1|root,COG0504@2|Bacteria,2G5U0@200795|Chloroflexi,376WB@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_725335_1 1504672.669785688 4.58e-105 309.0 COG0559@1|root,COG0559@2|Bacteria,1N0XX@1224|Proteobacteria,2VME0@28216|Betaproteobacteria,4AACC@80864|Comamonadaceae 28216|Betaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_662065_1 1005048.CFU_0197 8.53e-78 254.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,473SF@75682|Oxalobacteraceae 28216|Betaproteobacteria KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_404455_1 343516.Q286Z8_9CAUD 3.05e-57 200.0 4QGU6@10239|Viruses,4QYG2@35237|dsDNA viruses no RNA stage,4QPT8@28883|Caudovirales,4QP2X@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_118254_1 338966.Ppro_1408 6.89e-47 169.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RGKE@1224|Proteobacteria,42QA9@68525|delta/epsilon subdivisions 1224|Proteobacteria T Histidine kinase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF,GAF_2,Guanylate_cyc,HATPase_c,HD_5,HisKA,dCache_1 k59_154556_1 1123504.JQKD01000006_gene1566 1.34e-126 367.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,4ACTM@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Band 7 protein - - - - - - - - - - - - Band_7_1,HTH_17,SHOCT k59_614877_1 196367.JNFG01000007_gene6781 1.93e-28 107.0 COG1309@1|root,COG1309@2|Bacteria,1RH2C@1224|Proteobacteria,2W3K0@28216|Betaproteobacteria,1K6VN@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_614877_2 196367.JNFG01000007_gene6780 4.13e-20 83.6 2DAZQ@1|root,32TWF@2|Bacteria,1MZUJ@1224|Proteobacteria,2W47F@28216|Betaproteobacteria,1K8W0@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - Tautomerase k59_546196_1 1519464.HY22_08460 6.89e-25 110.0 COG2373@1|root,COG2373@2|Bacteria 2|Bacteria U Large extracellular alpha-helical protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,CarboxypepD_reg,Thiol-ester_cl k59_83281_1 1123508.JH636439_gene815 4.94e-60 196.0 COG4813@1|root,COG4813@2|Bacteria,2IZ2S@203682|Planctomycetes 203682|Planctomycetes G Trehalose utilisation - - - - - - - - - - - - ThuA k59_154565_1 338969.Rfer_2850 2.78e-97 300.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,4AC24@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aldehyde ferredoxin oxidoreductase aorA - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_370458_1 1500257.JQNM01000014_gene2953 2.36e-18 89.7 COG3934@1|root,COG3934@2|Bacteria,1R8MX@1224|Proteobacteria,2UF43@28211|Alphaproteobacteria,4BDF7@82115|Rhizobiaceae 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - - k59_48050_1 1123377.AUIV01000001_gene951 2.07e-24 95.9 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1X6DH@135614|Xanthomonadales 135614|Xanthomonadales J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_48050_2 981336.F944_00914 8.59e-43 140.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,3NPB6@468|Moraxellaceae 1236|Gammaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_48050_3 1265503.KB905173_gene4164 1.37e-07 53.1 COG2965@1|root,COG2965@2|Bacteria,1RHIE@1224|Proteobacteria,1S6H5@1236|Gammaproteobacteria,2Q76W@267889|Colwelliaceae 1236|Gammaproteobacteria L Binds single-stranded DNA at the primosome assembly site (PAS) priB GO:0000228,GO:0000428,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005658,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006270,GO:0006276,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016070,GO:0018130,GO:0019438,GO:0030880,GO:0030894,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0043596,GO:0043601,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0046483,GO:0050896,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990077,GO:1990099,GO:1990234,GO:1990837 - ko:K02686 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SSB k59_476322_1 1000565.METUNv1_00419 1.72e-122 384.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVEE@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg k59_476322_3 1000565.METUNv1_00417 8.1e-145 438.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,2WGSC@28216|Betaproteobacteria,2KVJK@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4 k59_1011863_1 1000565.METUNv1_01195 1.07e-107 343.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_462430_2 1000565.METUNv1_04060 5.88e-31 110.0 2E8DM@1|root,332S3@2|Bacteria,1ND1I@1224|Proteobacteria,2VX0K@28216|Betaproteobacteria,2KX9Z@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_462430_3 1000565.METUNv1_04059 4.46e-18 79.7 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,2KVJA@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S ferredoxin, iron-sulfur binding - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_7 k59_534094_2 1051985.l11_07830 2.86e-30 121.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,2KQ4F@206351|Neisseriales 206351|Neisseriales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_556886_1 338969.Rfer_0481 6.12e-133 388.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,4AAZ5@80864|Comamonadaceae 28216|Betaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_588515_1 1121447.JONL01000001_gene465 3.8e-42 157.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MHE4@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_697653_1 1000565.METUNv1_00755 1.83e-24 101.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,2KUBR@206389|Rhodocyclales 206389|Rhodocyclales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_697653_2 1000565.METUNv1_00754 7.64e-98 296.0 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,2VVFV@28216|Betaproteobacteria,2KWMY@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4115) - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_588519_1 1121035.AUCH01000002_gene1588 7.97e-52 174.0 COG3221@1|root,COG3221@2|Bacteria,1R49P@1224|Proteobacteria,2VN1C@28216|Betaproteobacteria,2KVS5@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - - - - - - - - - - Phosphonate-bd k59_462447_1 375286.mma_1352 3.1e-54 178.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,473MA@75682|Oxalobacteraceae 28216|Betaproteobacteria D Maf-like protein yceF - - ko:K06287 - - - - ko00000 - - - Maf k59_588520_1 351348.Maqu_1513 1.15e-08 59.7 2E302@1|root,32Y0M@2|Bacteria,1NAV6@1224|Proteobacteria,1SGP2@1236|Gammaproteobacteria,46AUJ@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_588520_2 1156919.QWC_20902 1.49e-38 138.0 COG4643@1|root,COG4643@2|Bacteria,1PH4V@1224|Proteobacteria,2W9H5@28216|Betaproteobacteria,3T7P0@506|Alcaligenaceae 28216|Betaproteobacteria P DNA integration - - - ko:K06919 - - - - ko00000 - - - - k59_462462_1 743299.Acife_2180 9.1e-64 204.0 28K0U@1|root,2Z9QP@2|Bacteria,1R4IB@1224|Proteobacteria,1S0W6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_462462_2 1123392.AQWL01000001_gene1675 2.31e-42 153.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2VGZB@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM DNA methylase N-4 N-6 - - 2.1.1.72 ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1061317_1 1304885.AUEY01000001_gene3149 4.73e-14 72.4 28JZ9@1|root,2Z9PC@2|Bacteria,1R7GE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1061317_2 1122951.ATUE01000010_gene347 1.66e-92 282.0 COG1638@1|root,COG1638@2|Bacteria,1PF2X@1224|Proteobacteria,1RQTV@1236|Gammaproteobacteria,3NK45@468|Moraxellaceae 1236|Gammaproteobacteria G TRAP-type C4-dicarboxylate transport system periplasmic component adeT - - - - - - - - - - - - k59_127884_1 85643.Tmz1t_1392 1.75e-96 293.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VK3J@28216|Betaproteobacteria,2KVS1@206389|Rhodocyclales 206389|Rhodocyclales E Diaminopimelate decarboxylase - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_412576_1 365046.Rta_33250 4.6e-47 169.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,4ABFF@80864|Comamonadaceae 28216|Betaproteobacteria S SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_272731_1 1122951.ATUE01000005_gene1907 1.09e-192 557.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,3NJZQ@468|Moraxellaceae 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_767458_1 543728.Vapar_4700 5.24e-107 315.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJHD@28216|Betaproteobacteria,4ACKX@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the arginase family - - 3.5.3.7 ko:K12255 ko00330,ko01100,map00330,map01100 - R01990 RC00024,RC00329 ko00000,ko00001,ko01000 - - - Arginase k59_412579_1 1217713.F993_01805 4.36e-39 142.0 COG1075@1|root,COG1075@2|Bacteria,1NB6J@1224|Proteobacteria,1RS95@1236|Gammaproteobacteria,3NJGV@468|Moraxellaceae 1236|Gammaproteobacteria S alpha/beta hydrolase fold - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_462496_1 1111728.ATYS01000034_gene35 1.07e-09 57.4 COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,1S9KM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yidB - - - - - - - - - - - DUF937 k59_462496_2 296591.Bpro_1341 2.04e-47 162.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,4AAMV@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - HemN_C,Radical_SAM k59_381133_1 1123360.thalar_00481 3.14e-33 126.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2U5GT@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_843459_1 760192.Halhy_1566 2.77e-28 117.0 COG3291@1|root,COG3291@2|Bacteria,4NMA6@976|Bacteroidetes 976|Bacteroidetes O Pregnancy-associated plasma protein-A - - - - - - - - - - - - Peptidase_M43,fn3 k59_945703_1 640081.Dsui_0368 1.03e-88 263.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,2KW86@206389|Rhodocyclales 206389|Rhodocyclales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_21180_1 614083.AWQR01000005_gene924 2.6e-73 233.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,4AAKI@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_21180_2 614083.AWQR01000005_gene925 1.63e-08 50.4 COG3197@1|root,COG3197@2|Bacteria,1PUR2@1224|Proteobacteria,2VXMN@28216|Betaproteobacteria,4AG10@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM cytochrome oxidase maturation protein, cbb3-type ccoS - - - - - - - - - - - FixS k59_622085_1 713587.THITH_13505 1.5e-07 55.8 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales 135613|Chromatiales L TIGRFAM Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_127932_1 1121904.ARBP01000002_gene6714 3.59e-36 139.0 COG2244@1|root,COG2244@2|Bacteria,4NK13@976|Bacteroidetes 976|Bacteroidetes S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt k59_231071_1 402626.Rpic_2266 3.17e-30 115.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1JZSY@119060|Burkholderiaceae 28216|Betaproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_556982_1 640081.Dsui_3307 5.81e-50 165.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,2VNV6@28216|Betaproteobacteria,2KUAF@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C k59_556982_2 640081.Dsui_3306 2.67e-46 158.0 2DBUZ@1|root,2ZB8W@2|Bacteria,1QWGF@1224|Proteobacteria,2VM8U@28216|Betaproteobacteria,2KVDM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_210925_1 1000565.METUNv1_00715 1.5e-69 219.0 COG2165@1|root,COG2165@2|Bacteria,1MZ5I@1224|Proteobacteria,2VU7P@28216|Betaproteobacteria,2KXCN@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, pseudopilin - - - - - - - - - - - - - k59_355491_1 85643.Tmz1t_0116 1.03e-24 98.2 COG0625@1|root,COG0625@2|Bacteria,1PPF9@1224|Proteobacteria,2VQQZ@28216|Betaproteobacteria,2KYGR@206389|Rhodocyclales 206389|Rhodocyclales O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_3,GST_N k59_164101_1 794846.AJQU01000040_gene5018 2.35e-79 245.0 COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria,4B80F@82115|Rhizobiaceae 28211|Alphaproteobacteria F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_272796_1 670307.HYPDE_26888 8.94e-23 105.0 COG3210@1|root,COG5295@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5295@2|Bacteria,COG5492@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria U TIGRFAM filamentous haemagglutinin family outer membrane protein - - - - - - - - - - - - ESPR,FG-GAP_2,Glug,Haemagg_act k59_983094_1 1218076.BAYB01000041_gene5639 2.03e-13 68.9 COG0847@1|root,COG0847@2|Bacteria,1N4WX@1224|Proteobacteria,2W4QX@28216|Betaproteobacteria 28216|Betaproteobacteria L dna polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_588609_1 977880.RALTA_B0337 9.78e-37 139.0 COG1511@1|root,COG1511@2|Bacteria,1QTXE@1224|Proteobacteria,2WGGR@28216|Betaproteobacteria,1K38B@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF802) - - - - - - - - - - - - DUF802 k59_734232_2 398578.Daci_3217 7.73e-47 164.0 COG2932@1|root,COG2932@2|Bacteria,1Q94I@1224|Proteobacteria,2VW1H@28216|Betaproteobacteria 28216|Betaproteobacteria K Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_1061472_1 1029823.AFIE01000065_gene451 7.87e-105 317.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,3NJM4@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_878268_1 1123255.JHYS01000004_gene965 1.84e-111 328.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,4AAJE@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_57525_1 28152.DJ57_2258 1.39e-49 174.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,1RZ7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_913188_1 1247649.D560_3906 4.65e-83 253.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,3T47H@506|Alcaligenaceae 28216|Betaproteobacteria L DDE domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_913188_2 497321.C664_17255 7.58e-43 141.0 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,2VUEP@28216|Betaproteobacteria,2KZKR@206389|Rhodocyclales 206389|Rhodocyclales L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_534332_1 1198452.Jab_2c30270 3.77e-84 266.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4725A@75682|Oxalobacteraceae 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_983130_1 448385.sce5468 3.27e-51 181.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_534335_2 365044.Pnap_3843 1.6e-21 91.7 COG0284@1|root,COG0284@2|Bacteria,1MWH5@1224|Proteobacteria,2VHAB@28216|Betaproteobacteria,4ACAT@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_622133_1 62928.azo1164 8.09e-28 106.0 2EDC2@1|root,3378B@2|Bacteria,1NBY0@1224|Proteobacteria,2W4WH@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_843565_1 614083.AWQR01000044_gene2010 1.51e-100 310.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,4AAEW@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1061513_1 1163409.UUA_12985 1.55e-84 259.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,1RPDI@1236|Gammaproteobacteria,1X58G@135614|Xanthomonadales 135614|Xanthomonadales L CRISPR-associated protein - - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_677520_1 981327.F925_02127 5.11e-13 73.6 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,3NITQ@468|Moraxellaceae 1236|Gammaproteobacteria P NMT1-like family - - - ko:K22067 - - - - ko00000,ko02022 - - - NMT1_2 k59_734263_1 1286170.RORB6_07965 2.84e-73 227.0 COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,1T1HV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_487087_1 1000565.METUNv1_02001 2.61e-114 347.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,2KUCJ@206389|Rhodocyclales 206389|Rhodocyclales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_843566_1 402626.Rpic_3601 1.16e-78 247.0 COG3203@1|root,COG3203@2|Bacteria,1R8AR@1224|Proteobacteria,2VHQG@28216|Betaproteobacteria,1K4MG@119060|Burkholderiaceae 28216|Betaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_57554_1 1085623.GNIT_2515 1.25e-15 83.2 COG5276@1|root,COG5276@2|Bacteria,1R5D5@1224|Proteobacteria,1RMBK@1236|Gammaproteobacteria,4664J@72275|Alteromonadaceae 1236|Gammaproteobacteria S Calx-beta domain - - - - - - - - - - - - Calx-beta,LVIVD,P_proprotein k59_734266_1 1000565.METUNv1_00882 7.04e-117 346.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VH0H@28216|Betaproteobacteria,2KW11@206389|Rhodocyclales 206389|Rhodocyclales M COG2148 Sugar transferases involved in lipopolysaccharide synthesis gumD - - ko:K03606 ko05111,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3 k59_697795_1 1461577.CCMH01000004_gene1178 6.84e-23 96.7 COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,1HWP1@117743|Flavobacteriia 976|Bacteroidetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_462684_1 62928.azo2527 7.93e-124 362.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2VPD5@28216|Betaproteobacteria,2KWNS@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome P450 - - - - - - - - - - - - p450 k59_1125224_1 1304883.KI912532_gene404 2.57e-102 313.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUBK@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_534380_1 196490.AUEZ01000011_gene6309 5.13e-81 253.0 COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2TUS1@28211|Alphaproteobacteria,3JRWA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_677552_2 614083.AWQR01000046_gene3336 3.44e-79 244.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2VHMJ@28216|Betaproteobacteria,4AAE3@80864|Comamonadaceae 28216|Betaproteobacteria N PFAM OmpA MotB domain protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_355660_1 1198452.Jab_1c13660 3.11e-134 405.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,472M3@75682|Oxalobacteraceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_128029_1 1000565.METUNv1_03877 1.94e-158 446.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,2KUPT@206389|Rhodocyclales 206389|Rhodocyclales L exodeoxyribonuclease III - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_381345_1 748247.AZKH_4082 2.36e-148 431.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,2KV3F@206389|Rhodocyclales 206389|Rhodocyclales C Nitrogenase component 1 type Oxidoreductase - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_767586_2 399795.CtesDRAFT_PD5089 2.32e-44 145.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2VVTR@28216|Betaproteobacteria,4AEUX@80864|Comamonadaceae 28216|Betaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_767586_3 391735.Veis_5012 1.21e-19 89.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,4AA59@80864|Comamonadaceae 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_462722_1 1504672.669783312 3.99e-92 280.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,4AA4T@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_165285_2 1480694.DC28_11525 1.6e-43 152.0 COG0842@1|root,COG0842@2|Bacteria 2|Bacteria V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_1095591_1 1267211.KI669560_gene2478 9e-38 137.0 COG2374@1|root,COG2374@2|Bacteria,4NEHG@976|Bacteroidetes,1IS63@117747|Sphingobacteriia 976|Bacteroidetes S Endonuclease exonuclease phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_274012_2 349521.HCH_03960 1.13e-36 139.0 COG2345@1|root,COG2345@2|Bacteria,1MXT0@1224|Proteobacteria,1SZZ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_1063316_1 1123261.AXDW01000010_gene283 4.57e-112 330.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1X397@135614|Xanthomonadales 135614|Xanthomonadales C also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_998173_1 365046.Rta_35410 1.35e-64 218.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,4AA7Z@80864|Comamonadaceae 28216|Betaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_35608_1 1000565.METUNv1_01833 6.53e-130 381.0 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - C5-epim_C,Wzy_C k59_35608_2 1095769.CAHF01000006_gene1730 9.52e-18 81.6 28JUE@1|root,2Z9JG@2|Bacteria,1R961@1224|Proteobacteria,2VNJ0@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_959080_1 1280696.ATVY01000056_gene3293 9.19e-25 103.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,4BYP1@830|Butyrivibrio 186801|Clostridia G Fructose-bisphosphate aldolase class-II fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_926868_1 1198452.Jab_2c16950 7.47e-110 327.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VJAJ@28216|Betaproteobacteria,476IB@75682|Oxalobacteraceae 28216|Betaproteobacteria JKL helicase superfamily c-terminal domain rhlE - - - - - - - - - - - DEAD,Helicase_C k59_633468_1 1408473.JHXO01000009_gene3374 9.99e-70 229.0 COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,4NEV7@976|Bacteroidetes,2FKZX@200643|Bacteroidia 976|Bacteroidetes J NOL1 NOP2 sun family protein rsmF - - - - - - - - - - - Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA k59_998199_1 1005048.CFU_4371 4.04e-132 395.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,4725N@75682|Oxalobacteraceae 28216|Betaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_959107_1 1095769.CAHF01000001_gene3509 1.16e-17 80.5 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,472US@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Dienelactone hydrolase family clcD - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_959107_2 95619.PM1_0213430 6.77e-47 163.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_959109_1 543728.Vapar_5771 3.46e-143 408.0 COG1028@1|root,COG1028@2|Bacteria,1MXFZ@1224|Proteobacteria,2VINF@28216|Betaproteobacteria,4AC6Y@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_35648_2 1331060.RLDS_13285 2.05e-15 75.9 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,2JZYW@204457|Sphingomonadales 204457|Sphingomonadales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_959128_2 1100721.ALKO01000029_gene38 9.63e-13 68.6 COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VISE@28216|Betaproteobacteria,4ABDZ@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_782033_1 396588.Tgr7_1539 1.06e-32 123.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_782033_2 1122951.ATUE01000006_gene1246 1.14e-27 109.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,3NJBR@468|Moraxellaceae 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1140828_1 381666.H16_A0007 2.22e-31 119.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria 1224|Proteobacteria L Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_782062_1 1406840.Q763_00050 1.76e-63 220.0 COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1HYJD@117743|Flavobacteriia,2NS7F@237|Flavobacterium 976|Bacteroidetes S Peptidase C25 porU - - - - - - - - - - - Peptidase_C25 k59_426475_1 1123393.KB891316_gene1370 1.35e-93 287.0 COG1215@1|root,COG1215@2|Bacteria,1R9CM@1224|Proteobacteria 1224|Proteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_926980_1 1121373.KB903633_gene771 1.73e-58 183.0 COG0394@1|root,COG0394@2|Bacteria,4NNN6@976|Bacteroidetes,47PU6@768503|Cytophagia 976|Bacteroidetes T Protein-tyrosine phosphatase, low molecular weight arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_927001_1 614083.AWQR01000003_gene2938 2.08e-18 84.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,4AA59@80864|Comamonadaceae 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_927001_2 1121116.KB894766_gene430 7.07e-31 111.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2VVTR@28216|Betaproteobacteria,4AEUX@80864|Comamonadaceae 28216|Betaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_927001_3 1123255.JHYS01000002_gene2382 6.47e-41 140.0 COG0594@1|root,COG0594@2|Bacteria,1RI80@1224|Proteobacteria,2VSD0@28216|Betaproteobacteria,4AEFM@80864|Comamonadaceae 28216|Betaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme - - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_927034_1 880071.Fleli_0127 1.62e-37 144.0 COG2208@1|root,COG3292@1|root,COG2208@2|Bacteria,COG3292@2|Bacteria,4PMED@976|Bacteroidetes,47Y31@768503|Cytophagia 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - Reg_prop,SpoIIE,Y_Y_Y k59_712985_1 748247.AZKH_4060 1.73e-133 392.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,2KV00@206389|Rhodocyclales 206389|Rhodocyclales C Dinitrogenase iron-molybdenum cofactor - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_1140917_1 1121033.AUCF01000016_gene5507 1.68e-37 134.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TT8X@28211|Alphaproteobacteria,2JQQR@204441|Rhodospirillales 204441|Rhodospirillales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_959262_1 700598.Niako_6724 1.9e-41 149.0 COG0389@1|root,COG0389@2|Bacteria,4NGPH@976|Bacteroidetes,1IPQQ@117747|Sphingobacteriia 976|Bacteroidetes L COGs COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair umuC - - ko:K03502 - - - - ko00000,ko03400 - - - DUF4113,IMS,IMS_C,IMS_HHH k59_959262_2 925409.KI911562_gene1113 2.8e-15 74.3 COG1801@1|root,COG1801@2|Bacteria,4NHAD@976|Bacteroidetes,1IP8N@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_499674_1 1000565.METUNv1_01973 3.92e-59 201.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KVZ6@206389|Rhodocyclales 206389|Rhodocyclales S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_1106416_1 1000565.METUNv1_02901 1.21e-167 483.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,2KV0F@206389|Rhodocyclales 206389|Rhodocyclales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_35694_1 543632.JOJL01000014_gene9183 3.47e-13 70.5 COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4D9Y8@85008|Micromonosporales 201174|Actinobacteria G phosphoglycerate mutase - - 3.1.3.85 ko:K22306 - - - - ko00000,ko01000 - - - His_Phos_1 k59_35694_2 438753.AZC_2523 2.18e-34 125.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2TT9A@28211|Alphaproteobacteria,3EZM9@335928|Xanthobacteraceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_571060_1 1000565.METUNv1_03314 4.01e-179 509.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales 206389|Rhodocyclales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_356920_1 543728.Vapar_0276 2.4e-102 303.0 COG1802@1|root,COG1802@2|Bacteria,1MW9G@1224|Proteobacteria,2VQ9U@28216|Betaproteobacteria,4AASN@80864|Comamonadaceae 28216|Betaproteobacteria K Regulatory protein GntR HTH - - - - - - - - - - - - FCD,GntR k59_571063_1 1454004.AW11_02203 1.03e-09 58.2 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria 28216|Betaproteobacteria E Asparagine synthase asnB1 - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_571063_2 1000565.METUNv1_03758 1.61e-207 580.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KUXN@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_713832_1 391596.PBAL39_09461 4.19e-82 255.0 COG0356@1|root,COG0356@2|Bacteria,4NEPK@976|Bacteroidetes,1IPTF@117747|Sphingobacteriia 976|Bacteroidetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1035049_1 197221.22294101 9.54e-51 178.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria 1117|Cyanobacteria O O-linked N-acetylglucosamine transferase SPINDLY family - - - - - - - - - - - - Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_499694_2 1000565.METUNv1_02294 3.72e-119 343.0 COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2VSQB@28216|Betaproteobacteria,2KWPT@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF934) - - - - - - - - - - - - DUF934 k59_713841_1 1121004.ATVC01000039_gene2368 1.92e-56 197.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,2KSKX@206351|Neisseriales 206351|Neisseriales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_642469_1 1000565.METUNv1_01661 1.78e-110 323.0 COG1161@1|root,COG1161@2|Bacteria,1MV5H@1224|Proteobacteria,2VHAG@28216|Betaproteobacteria,2KVMC@206389|Rhodocyclales 206389|Rhodocyclales S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity - - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_499698_1 1265502.KB905975_gene589 1.22e-36 124.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,4AEUE@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the sulfur carrier protein TusA family sirA - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_499698_2 296591.Bpro_3726 6.99e-95 283.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,4AC80@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysM GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_142806_1 1177181.T9A_00470 6.68e-103 305.0 COG3687@1|root,COG3687@2|Bacteria,1MWGV@1224|Proteobacteria,1RZKP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_713858_1 640081.Dsui_2730 1.95e-107 313.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,2KUMD@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the SUA5 family yrdC - - - - - - - - - - - Sua5_yciO_yrdC k59_713858_2 522306.CAP2UW1_2976 1.1e-80 247.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,1KQ12@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S DNA polymerase alpha chain like domain - GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_107099_1 29581.BW37_02157 3.66e-18 86.3 COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria,4791Q@75682|Oxalobacteraceae 28216|Betaproteobacteria T Y_Y_Y domain - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1 k59_428342_1 755732.Fluta_1214 3.47e-40 142.0 COG0626@1|root,COG0626@2|Bacteria,4NF0Q@976|Bacteroidetes,1HXPE@117743|Flavobacteriia,2PA8D@246874|Cryomorphaceae 976|Bacteroidetes E PFAM Cys Met metabolism PLP-dependent enzyme metC - 2.5.1.48,4.4.1.1,4.4.1.8 ko:K01739,ko:K01758,ko:K01760 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_428342_2 1237149.C900_02621 1.29e-25 98.2 COG1393@1|root,COG1393@2|Bacteria,4NSAW@976|Bacteroidetes 976|Bacteroidetes P Belongs to the ArsC family - - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_249883_1 85643.Tmz1t_2116 2.6e-107 324.0 2DBCS@1|root,2Z8FF@2|Bacteria,1QVT2@1224|Proteobacteria,2WGTR@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_48_1 595537.Varpa_3290 1.09e-52 177.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VJI2@28216|Betaproteobacteria,4AAGM@80864|Comamonadaceae 28216|Betaproteobacteria EJ PFAM Asparaginase glutaminase ansB - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_48_2 1000565.METUNv1_03413 1.49e-75 240.0 COG4943@1|root,COG4943@2|Bacteria,1MVTH@1224|Proteobacteria,2VNSA@28216|Betaproteobacteria 28216|Betaproteobacteria T signal transduction protein containing sensor and EAL - - - - - - - - - - - - CSS-motif,EAL k59_749555_1 614083.AWQR01000010_gene1534 1.94e-104 325.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,4AAM8@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_499719_1 1218084.BBJK01000124_gene7011 3.49e-98 316.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K35G@119060|Burkholderiaceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9,SBP_bac_3,dCache_1 k59_499719_2 1100720.ALKN01000034_gene570 1.55e-134 400.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2VJHS@28216|Betaproteobacteria,4AA9C@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Sulfatase - - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_571086_1 204773.HEAR0899 7.15e-40 146.0 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,472TC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8 k59_285577_1 1449049.JONW01000009_gene4558 1.21e-15 76.6 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2KF79@204458|Caulobacterales 204458|Caulobacterales I poly(R)-hydroxyalkanoic acid synthase - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_285577_2 1000565.METUNv1_03297 4.65e-50 177.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales 206389|Rhodocyclales KNT COG0643 Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_142825_1 887898.HMPREF0551_0642 1.11e-163 466.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,1K04Y@119060|Burkholderiaceae 28216|Betaproteobacteria S Polyphosphate kinase 2 (PPK2) ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_35745_1 1000565.METUNv1_02231 4.64e-128 377.0 COG1538@1|root,COG1538@2|Bacteria,1PKUI@1224|Proteobacteria,2VMC6@28216|Betaproteobacteria,2KX9S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_35745_2 1192759.AKIB01000061_gene2003 3.06e-13 72.0 2E43T@1|root,32Z04@2|Bacteria,1R9ZK@1224|Proteobacteria,2U6I7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_820963_1 1000565.METUNv1_03515 5.21e-106 312.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,2KUZK@206389|Rhodocyclales 206389|Rhodocyclales S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_606758_1 1121035.AUCH01000014_gene2459 8.65e-64 212.0 COG4656@1|root,COG4656@2|Bacteria,1QD61@1224|Proteobacteria,2VJTD@28216|Betaproteobacteria,2KV7Y@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB k59_606758_2 62928.azo0516 1.17e-54 177.0 COG2878@1|root,COG2878@2|Bacteria,1RE44@1224|Proteobacteria,2VR3H@28216|Betaproteobacteria,2KWC7@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_606758_3 665029.EAMY_1722 4.77e-74 229.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,3X52J@551|Erwinia 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_606758_4 1286631.X805_35000 9.56e-226 629.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1KJQM@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_606758_5 1071679.BG57_19865 1.57e-74 225.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1K6Y7@119060|Burkholderiaceae 28216|Betaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters iscU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_606758_6 1538295.JY96_18600 2.63e-53 170.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1KKSP@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Required for insertion of 4Fe-4S clusters erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_606758_7 243233.MCA0250 1.02e-51 165.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1XGGY@135618|Methylococcales 135618|Methylococcales C Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_606758_8 864073.HFRIS_009625 2.44e-193 557.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,472BD@75682|Oxalobacteraceae 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_321314_2 1123399.AQVE01000057_gene317 5.7e-22 97.8 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - RHS_repeat k59_142828_2 1000565.METUNv1_01934 5.64e-159 454.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KVC9@206389|Rhodocyclales 206389|Rhodocyclales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_464052_1 1121035.AUCH01000005_gene108 2.47e-229 652.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales 206389|Rhodocyclales C Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_428376_2 1000565.METUNv1_03433 6.06e-99 296.0 COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2VXJI@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_428376_3 1000565.METUNv1_03434 8.46e-22 89.0 COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2VU9I@28216|Betaproteobacteria,2KZF6@206389|Rhodocyclales 206389|Rhodocyclales S DoxX - - - - - - - - - - - - DoxX k59_785287_1 1349767.GJA_57 1.21e-19 87.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,4723Z@75682|Oxalobacteraceae 28216|Betaproteobacteria E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_392657_1 1000565.METUNv1_02572 1.47e-223 619.0 COG1857@1|root,COG1857@2|Bacteria,1MVNH@1224|Proteobacteria,2VP5P@28216|Betaproteobacteria,2KYSV@206389|Rhodocyclales 206389|Rhodocyclales L CT1975-like protein - - - ko:K19124 - - - - ko00000,ko02048 - - - Cas_CT1975 k59_392657_2 1000565.METUNv1_02571 3.28e-157 443.0 2A1HF@1|root,30PR5@2|Bacteria,1PWCJ@1224|Proteobacteria,2WBXB@28216|Betaproteobacteria,2KZE7@206389|Rhodocyclales 206389|Rhodocyclales S CRISPR-associated protein (Cas_Cas5) - - - ko:K19125 - - - - ko00000,ko02048 - - - Cas_Cas5d k59_392657_3 1000565.METUNv1_02570 6.03e-157 441.0 2DMV2@1|root,32TV5@2|Bacteria,1RCB3@1224|Proteobacteria,2VTY3@28216|Betaproteobacteria 28216|Betaproteobacteria S CRISPR_assoc casE - - ko:K19126 - - - - ko00000,ko02048 - - - CRISPR_assoc k59_392657_4 870187.Thini_0238 7.67e-31 112.0 COG2886@1|root,COG2886@2|Bacteria,1N9SY@1224|Proteobacteria,1SRR2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0175) - - - - - - - - - - - - UPF0175 k59_392657_6 565033.GACE_1107 1.54e-06 48.1 COG2405@1|root,arCOG00717@2157|Archaea 2157|Archaea S nucleic acid-binding protein contains PIN domain - - - - - - - - - - - - DUF3368 k59_392657_7 1000565.METUNv1_02569 4.39e-215 594.0 COG1518@1|root,COG1518@2|Bacteria,1MUXH@1224|Proteobacteria,2VMT9@28216|Betaproteobacteria,2KY6C@206389|Rhodocyclales 206389|Rhodocyclales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - - - - - - - - - - Cas_Cas1 k59_392657_8 1000565.METUNv1_02568 2.43e-64 196.0 COG0847@1|root,COG0847@2|Bacteria,1N05B@1224|Proteobacteria,2VUI9@28216|Betaproteobacteria,2KZ4B@206389|Rhodocyclales 206389|Rhodocyclales L CRISPR-associated protein (Cas_Cas2CT1978) - - - - - - - - - - - - Cas_Cas2CT1978 k59_678189_1 204773.HEAR2830 1.06e-33 129.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2VIDP@28216|Betaproteobacteria,476ZQ@75682|Oxalobacteraceae 28216|Betaproteobacteria M Beta-lactamase - - - - - - - - - - - - Beta-lactamase,META k59_392659_1 629773.AORY01000001_gene2262 7.44e-38 134.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,2K4AW@204457|Sphingomonadales 204457|Sphingomonadales S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep k59_285602_1 1000565.METUNv1_03751 2.7e-189 545.0 2DBM3@1|root,2Z9WX@2|Bacteria,1R676@1224|Proteobacteria,2VPUB@28216|Betaproteobacteria,2KWS6@206389|Rhodocyclales 206389|Rhodocyclales S TIGRFAM PEP-CTERM system associated protein - - - - - - - - - - - - - k59_856647_1 946483.Cenrod_1902 2.1e-53 187.0 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_4,PAS_9,Response_reg k59_35764_1 1040989.AWZU01000087_gene2199 2.62e-59 200.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3K2JR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_892360_1 497321.C664_08213 1.45e-18 84.3 COG1247@1|root,COG1247@2|Bacteria,1PJY7@1224|Proteobacteria 1224|Proteobacteria M Acetyltransferase (GNAT) family - - - - - - - - - - - - - k59_321333_1 1000565.METUNv1_04007 1.25e-175 491.0 COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,2VK9S@28216|Betaproteobacteria,2KVCJ@206389|Rhodocyclales 206389|Rhodocyclales T phosphatase - - - - - - - - - - - - PP2C_2 k59_321333_2 76114.ebA4497 1.3e-147 427.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,2KVAK@206389|Rhodocyclales 206389|Rhodocyclales C NAD(P) transhydrogenase, alpha subunit pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_95_1 1000565.METUNv1_02257 9.44e-198 587.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KUZA@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1106503_1 305700.B447_02733 6.67e-79 254.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,2VJKQ@28216|Betaproteobacteria,2KV2F@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_428413_1 1000565.METUNv1_02507 1.18e-31 122.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KV93@206389|Rhodocyclales 206389|Rhodocyclales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_285622_1 1000565.METUNv1_03787 8e-138 397.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,2KUCT@206389|Rhodocyclales 206389|Rhodocyclales M Male sterility protein - - 5.1.3.7 ko:K02473 ko00520,ko01100,map00520,map01100 - R00418 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_285622_2 1000565.METUNv1_03788 3.15e-140 404.0 COG0741@1|root,COG0790@1|root,COG0741@2|Bacteria,COG0790@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria,2KV7Z@206389|Rhodocyclales 206389|Rhodocyclales M Lytic transglycosylase - - - - - - - - - - - - SLT,Sel1 k59_285622_3 1454004.AW11_00353 9.15e-68 216.0 COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,2VQ55@28216|Betaproteobacteria 28216|Betaproteobacteria O peptidase S1 and S6, chymotrypsin Hap - - - - - - - - - - - - Trypsin_2 k59_35794_1 338969.Rfer_1911 1.85e-106 318.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,4A9MU@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM aminotransferase, class I and II alaA - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_214235_1 686340.Metal_3889 4.21e-68 229.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XEQ3@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_214235_2 358220.C380_23110 3.47e-23 99.4 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2VIDH@28216|Betaproteobacteria,4AAUQ@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_357038_1 1000565.METUNv1_01589 2.68e-07 50.8 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,2KVW9@206389|Rhodocyclales 206389|Rhodocyclales S Inhibitor of apoptosis-promoting Bax1 - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_357038_2 1000565.METUNv1_01590 4.68e-72 229.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,2KVES@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_749597_1 391596.PBAL39_14479 2.49e-44 145.0 COG3549@1|root,COG3549@2|Bacteria,4NSZ2@976|Bacteroidetes,1J14E@117747|Sphingobacteriia 976|Bacteroidetes S COG3549 Plasmid maintenance system killer protein - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_749597_2 1267211.KI669560_gene2657 1.05e-43 143.0 COG3093@1|root,COG3093@2|Bacteria,4NSBZ@976|Bacteroidetes,1ITK1@117747|Sphingobacteriia 976|Bacteroidetes K Helix-turn-helix - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_571135_1 948106.AWZT01000063_gene4073 9.82e-41 154.0 COG0784@1|root,COG0834@1|root,COG3829@1|root,COG4251@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,1KIGI@119060|Burkholderiaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,SBP_bac_3 k59_785326_1 1328313.DS2_08605 1.04e-140 433.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465AJ@72275|Alteromonadaceae 1236|Gammaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_821002_1 1000565.METUNv1_01848 3.56e-31 118.0 COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria 28216|Betaproteobacteria S short chain amide porin - - - - - - - - - - - - - k59_821002_2 1000565.METUNv1_01848 1.78e-96 295.0 COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria 28216|Betaproteobacteria S short chain amide porin - - - - - - - - - - - - - k59_142864_1 1000565.METUNv1_01511 2.71e-272 755.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,2KVX2@206389|Rhodocyclales 206389|Rhodocyclales C aldehyde ferredoxin oxidoreductase aorA - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_749602_2 225937.HP15_824 5.8e-60 194.0 COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,1S3H1@1236|Gammaproteobacteria,46DGI@72275|Alteromonadaceae 1236|Gammaproteobacteria G phosphoglycerate mutase - - - - - - - - - - - - His_Phos_1 k59_392706_1 1100720.ALKN01000028_gene2618 1.37e-15 74.7 COG3639@1|root,COG3639@2|Bacteria,1N3HU@1224|Proteobacteria,2VMR7@28216|Betaproteobacteria,4AAAB@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_392706_2 1100720.ALKN01000028_gene2619 1.09e-46 159.0 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2VKCA@28216|Betaproteobacteria,4AAV0@80864|Comamonadaceae 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component phnE - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_713948_1 1000565.METUNv1_01637 1.07e-28 117.0 2EMF3@1|root,2ZKNW@2|Bacteria,1RAZA@1224|Proteobacteria,2VQE2@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_107795_1 1000565.METUNv1_02612 6.75e-144 410.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,2KVRQ@206389|Rhodocyclales 206389|Rhodocyclales H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_893161_1 614083.AWQR01000038_gene1441 5e-09 57.8 COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,2VTQI@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_893161_2 1000565.METUNv1_02024 1.52e-80 250.0 COG0438@1|root,COG0438@2|Bacteria,1NE5D@1224|Proteobacteria,2VWY9@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_464883_1 748247.AZKH_0332 1.16e-46 161.0 2CJJV@1|root,30VBX@2|Bacteria,1RGSF@1224|Proteobacteria,2VS5D@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_536067_1 1000565.METUNv1_02593 4.24e-98 316.0 COG1639@1|root,COG3852@1|root,COG1639@2|Bacteria,COG3852@2|Bacteria,1R444@1224|Proteobacteria,2VJPB@28216|Betaproteobacteria,2KZQ9@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HATPase_c,HDOD k59_357904_1 1000565.METUNv1_03297 5.63e-125 398.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales 206389|Rhodocyclales KNT COG0643 Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_357904_2 1348657.M622_11235 7.86e-120 367.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_982_1 1000565.METUNv1_02632 3.54e-189 536.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,2VHVZ@28216|Betaproteobacteria,2KV50@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar biosynthesis regulator FlhF flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_107799_1 1000565.METUNv1_01947 8.56e-255 743.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales 206389|Rhodocyclales E glutamate synthase gls1 - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_512599_1 236097.ADG881_128 3.04e-123 361.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1XHTS@135619|Oceanospirillales 135619|Oceanospirillales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metX - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1113121_1 1111732.AZOD01000009_gene1227 4.75e-06 47.0 COG4570@1|root,COG4570@2|Bacteria,1NMFN@1224|Proteobacteria,1SSHS@1236|Gammaproteobacteria,1X8VR@135614|Xanthomonadales 135614|Xanthomonadales L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC - - - - - - - - - - - - - k59_1113121_4 194699.Q775B8_BPBPP 3.96e-41 144.0 4QP0S@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1113121_5 298386.PBPRB0566 4.57e-09 57.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,1RZWT@1236|Gammaproteobacteria,1XZBB@135623|Vibrionales 135623|Vibrionales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_258768_1 631362.Thi970DRAFT_03729 6.18e-15 83.2 COG1572@1|root,COG2911@1|root,COG3210@1|root,COG4625@1|root,COG4932@1|root,COG1572@2|Bacteria,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T4WQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Protein conserved in bacteria - - - - - - - - - - - - Cadherin,DUF4347 k59_366100_1 296591.Bpro_1622 5.07e-168 476.0 COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,4ABK8@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_401446_1 1114922.CIFAM_04_01760 4.62e-24 102.0 COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,1RRDM@1236|Gammaproteobacteria,3WV9X@544|Citrobacter 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0149) yecA - - ko:K07039 - - - - ko00000 - - - SEC-C,UPF0149 k59_721763_1 1485544.JQKP01000015_gene2099 6.9e-16 74.7 COG1669@1|root,COG1669@2|Bacteria,1R0XG@1224|Proteobacteria,2WHY0@28216|Betaproteobacteria 28216|Betaproteobacteria L Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 k59_721763_2 1163408.UU9_10522 8.51e-58 183.0 2AXM7@1|root,32QW1@2|Bacteria,1RKID@1224|Proteobacteria,1S7EY@1236|Gammaproteobacteria,1XAGV@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_258794_1 292415.Tbd_1042 9.08e-77 256.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GAF,GAF_2,GGDEF,NMT1,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_512663_1 439235.Dalk_3876 8.62e-45 151.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2MKR0@213118|Desulfobacterales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_333978_1 202954.BBNK01000008_gene1488 1.04e-48 169.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,3NJ00@468|Moraxellaceae 1236|Gammaproteobacteria M zinc metalloprotease rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_333978_2 1121374.KB891586_gene2469 9.23e-13 69.3 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_441608_1 1169143.KB911035_gene2284 1.59e-42 142.0 COG2030@1|root,COG2030@2|Bacteria,1RC6U@1224|Proteobacteria,2VQU2@28216|Betaproteobacteria,1K2E0@119060|Burkholderiaceae 28216|Betaproteobacteria I PFAM MaoC domain protein dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_441608_2 1157708.KB907462_gene968 3.2e-51 172.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMXZ@28216|Betaproteobacteria,4AH7A@80864|Comamonadaceae 28216|Betaproteobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_685178_1 1100721.ALKO01000003_gene2450 4.29e-80 249.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,4ACK5@80864|Comamonadaceae 28216|Betaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_81530_1 1122951.ATUE01000008_gene169 1.31e-146 423.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,3NIXJ@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_831903_1 1000565.METUNv1_03599 3.69e-171 486.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VJ0X@28216|Betaproteobacteria,2KVB0@206389|Rhodocyclales 206389|Rhodocyclales F Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_831908_1 290397.Adeh_3754 4.92e-21 91.3 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Formate dehydrogenase, alpha subunit fdhA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016622,GO:0016903,GO:0018282,GO:0018289,GO:0018291,GO:0019538,GO:0022607,GO:0031163,GO:0032991,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0047111,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:1901564,GO:1902494 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_831908_2 557598.LHK_00802 9e-37 132.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VHPC@28216|Betaproteobacteria,2KQ4I@206351|Neisseriales 206351|Neisseriales C formate dehydrogenase fdoH - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_11,Fer4_4,Form-deh_trans k59_1114721_1 338969.Rfer_1894 9.22e-32 121.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2VH7I@28216|Betaproteobacteria,4AEW0@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1,Sugar_tr k59_757922_1 1000565.METUNv1_04055 9.5e-168 490.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_10 k59_474346_1 1265502.KB905930_gene1571 3.04e-79 258.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,4AAPA@80864|Comamonadaceae 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1010259_1 614083.AWQR01000039_gene1493 6.44e-42 150.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VH58@28216|Betaproteobacteria,4AB0M@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cytochrom_C k59_796280_1 1000565.METUNv1_03497 4.05e-124 376.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,2KVA6@206389|Rhodocyclales 206389|Rhodocyclales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_260662_1 614083.AWQR01000030_gene2740 2.93e-109 327.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,4AAN9@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_757937_2 1219049.SP5_035_01160 2.2e-10 65.5 2EGG4@1|root,33A85@2|Bacteria,1NISE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1087192_1 204773.HEAR0429 7.29e-107 317.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2VH12@28216|Betaproteobacteria,472JF@75682|Oxalobacteraceae 28216|Betaproteobacteria P transporter, permease nasE - - ko:K15577 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - BPD_transp_1 k59_686761_1 78245.Xaut_2330 3.09e-11 62.8 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,3EY3I@335928|Xanthobacteraceae 28211|Alphaproteobacteria C PFAM aldo keto reductase - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red k59_686761_2 189753.AXAS01000037_gene7859 2.8e-11 63.9 COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,3JT2S@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase fixR - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_260686_1 393595.ABO_0081 2.47e-78 237.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1XJJM@135619|Oceanospirillales 135619|Oceanospirillales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_297296_1 1000565.METUNv1_02007 3.22e-16 77.0 COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2WA5U@28216|Betaproteobacteria,2KXHH@206389|Rhodocyclales 206389|Rhodocyclales S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB k59_297296_2 1000565.METUNv1_02006 2.08e-168 494.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUJZ@206389|Rhodocyclales 206389|Rhodocyclales T Cache 3/Cache 2 fusion domain - - - - - - - - - - - - Cache_3-Cache_2,MCPsignal k59_659083_1 589865.DaAHT2_1636 8.02e-66 216.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_46294_1 243365.CV_3861 4.12e-85 273.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2VPHV@28216|Betaproteobacteria 28216|Betaproteobacteria D Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail k59_659095_1 640081.Dsui_2769 3.68e-65 223.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VMEI@28216|Betaproteobacteria,2KX67@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,Thiol-ester_cl k59_659100_2 1380370.JIBA01000019_gene1136 9.85e-10 58.9 COG2267@1|root,COG2267@2|Bacteria,2I0NW@201174|Actinobacteria,4FI10@85021|Intrasporangiaceae 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_936510_1 62928.azo2966 1.07e-66 207.0 COG2259@1|root,COG2259@2|Bacteria,1RDYW@1224|Proteobacteria 1224|Proteobacteria S Doxx family mhqP - - ko:K15977 - - - - ko00000 - - - DoxX k59_757965_1 1439940.BAY1663_01585 8.06e-22 91.3 COG1502@1|root,COG1502@2|Bacteria,1NXTE@1224|Proteobacteria 1224|Proteobacteria I phospholipase d transphosphatidylase - - - - - - - - - - - - PLDc_2 k59_757965_2 232721.Ajs_2204 2.69e-83 263.0 28HBW@1|root,2Z7NV@2|Bacteria,1N8Z2@1224|Proteobacteria,2VITM@28216|Betaproteobacteria,4AC15@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1998) - - - - - - - - - - - - DUF1998 k59_152464_1 614083.AWQR01000040_gene753 6.37e-97 292.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VH77@28216|Betaproteobacteria,4AAT7@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FMN-dependent alpha-hydroxy acid dehydrogenase lldD - 1.1.2.3,1.1.3.15 ko:K00101,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00196,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_297315_1 1286631.X805_26810 2.28e-91 282.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,1KK9D@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nitrogenase cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_579324_1 794903.OPIT5_26140 1.57e-162 481.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46TNN@74201|Verrucomicrobia,3K7A5@414999|Opitutae 414999|Opitutae G Belongs to the PEP-utilizing enzyme family - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_297316_1 375286.mma_2095 4.31e-143 424.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,4735N@75682|Oxalobacteraceae 28216|Betaproteobacteria NT CheY binding cheA GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_544320_1 398578.Daci_1285 4.15e-41 145.0 COG0665@1|root,COG0665@2|Bacteria,1R7JH@1224|Proteobacteria,2VP2K@28216|Betaproteobacteria,4ACSV@80864|Comamonadaceae 28216|Betaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_544320_2 595537.Varpa_1139 5.29e-05 45.4 COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,4ACCU@80864|Comamonadaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1087247_1 1000565.METUNv1_00380 1.49e-107 327.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_903477_1 1145276.T479_05885 2.38e-18 90.9 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,3IZG9@400634|Lysinibacillus 91061|Bacilli Q COG1020 Non-ribosomal peptide synthetase modules and related proteins pksM3 - - ko:K13611,ko:K13614,ko:K15654 ko01054,ko02024,map01054,map02024 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_116529_1 1124780.ANNU01000021_gene3023 2.4e-69 228.0 COG1018@1|root,COG1018@2|Bacteria,4NF24@976|Bacteroidetes,47KY6@768503|Cytophagia 976|Bacteroidetes C PFAM 2Fe-2S iron-sulfur cluster binding domain dmpP - - ko:K02613 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_444820_1 1198452.Jab_2c02840 8.9e-126 362.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,472J2@75682|Oxalobacteraceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_297322_1 1437448.AZRT01000050_gene161 6.41e-32 123.0 COG0863@1|root,COG0863@2|Bacteria,1PCSC@1224|Proteobacteria,2U4M6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_297322_2 1236000.L0AQZ2_9CAUD 6.96e-23 93.2 4QEGD@10239|Viruses,4QVU1@35237|dsDNA viruses no RNA stage,4QPN9@28883|Caudovirales,4QJCM@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_544329_1 395494.Galf_1712 1.81e-61 197.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,2VNBH@28216|Betaproteobacteria 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_544329_2 1304883.KI912532_gene223 7.85e-29 114.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,2KV5X@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_972186_1 930169.B5T_03017 1.56e-63 206.0 COG3250@1|root,COG3250@2|Bacteria,1R87I@1224|Proteobacteria,1RZ7F@1236|Gammaproteobacteria,1XJ8X@135619|Oceanospirillales 135619|Oceanospirillales G Protein of unknown function (DUF2804) - - - - - - - - - - - - DUF2804 k59_757976_1 1123487.KB892841_gene4301 6.84e-88 275.0 28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,2KW13@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_757976_2 1122135.KB893134_gene3729 1.18e-26 106.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB,YceI k59_723534_1 1095769.CAHF01000022_gene396 1.47e-53 178.0 COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria,2WETH@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_81633_1 1453496.AT03_13765 3.39e-51 179.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II JD73_00810 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C_2,PP-binding k59_544333_1 1000565.METUNv1_00046 2.02e-140 441.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_757987_1 1000565.METUNv1_02991 3.03e-94 282.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,2KWHK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_796387_1 1031711.RSPO_c02166 1.88e-57 189.0 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_579347_1 243160.BMA1789 4e-16 75.5 2DRVE@1|root,33D8G@2|Bacteria,1P1ND@1224|Proteobacteria,2W3YJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1044981_1 159087.Daro_2462 6.75e-46 157.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,2KUXV@206389|Rhodocyclales 206389|Rhodocyclales S metal-dependent phosphoesterases (PHP family) - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_1044981_2 1000565.METUNv1_00830 2.2e-131 374.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,2KUMD@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the SUA5 family yrdC - - - - - - - - - - - Sua5_yciO_yrdC k59_796393_1 580332.Slit_2092 1.38e-41 142.0 COG2703@1|root,COG2703@2|Bacteria,1NEJC@1224|Proteobacteria,2VXCP@28216|Betaproteobacteria 28216|Betaproteobacteria P Hemerythrin-like metal-binding protein - - - - - - - - - - - - Hemerythrin k59_194470_1 977880.RALTA_A1036 3.76e-88 263.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1K15D@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_474451_1 1000565.METUNv1_00462 1.27e-98 295.0 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,2KV4I@206389|Rhodocyclales 206389|Rhodocyclales P ZIP Zinc transporter - - - ko:K16267 - - - - ko00000,ko02000 2.A.5.4.11 - - Zip k59_46349_1 1000565.METUNv1_02045 5.32e-127 374.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales 206389|Rhodocyclales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_221484_1 1000565.METUNv1_03442 1.21e-125 390.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,2KUJ2@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_613648_1 1000565.METUNv1_02968 1.45e-115 350.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,2KUGX@206389|Rhodocyclales 206389|Rhodocyclales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_796403_2 1433126.BN938_1266 1.66e-07 55.1 COG2071@1|root,COG2071@2|Bacteria,4PM5S@976|Bacteroidetes,2G0PJ@200643|Bacteroidia,22VCR@171550|Rikenellaceae 976|Bacteroidetes S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_972211_1 1000565.METUNv1_00265 1.61e-74 243.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales 206389|Rhodocyclales C Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_972211_2 1000565.METUNv1_00266 1.18e-61 199.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales 206389|Rhodocyclales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_337047_2 253839.SSNG_05644 3.08e-13 69.7 COG0236@1|root,COG0736@1|root,COG0236@2|Bacteria,COG0736@2|Bacteria,2GRVS@201174|Actinobacteria 201174|Actinobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein - - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_936566_1 224911.27351467 5.56e-74 239.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,3JQYV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G ABC transporter gguA - 3.6.3.17 ko:K10548 ko02010,map02010 M00216 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.5 - - ABC_tran k59_579365_1 1458427.BAWN01000021_gene1379 4.54e-110 323.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,4AA7B@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_723582_1 305900.GV64_23245 3.02e-95 308.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XH56@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_214396_2 1000565.METUNv1_00478 0.0 1259.0 COG2911@1|root,COG2911@2|Bacteria,1QWGG@1224|Proteobacteria,2WGYX@28216|Betaproteobacteria,2KZX3@206389|Rhodocyclales 206389|Rhodocyclales S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_36049_1 1000565.METUNv1_02251 3.78e-115 330.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,2KUIE@206389|Rhodocyclales 206389|Rhodocyclales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_368_2 1000565.METUNv1_00891 2.66e-168 482.0 COG3206@1|root,COG3206@2|Bacteria,1RK0N@1224|Proteobacteria,2VHPS@28216|Betaproteobacteria,2KZRD@206389|Rhodocyclales 206389|Rhodocyclales M G-rich domain on putative tyrosine kinase gumC - - - - - - - - - - - GNVR,Wzz k59_107341_1 1000565.METUNv1_02015 9.87e-210 631.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,2KVBJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_321678_1 1000565.METUNv1_02457 1.07e-215 607.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KVJ8@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - FHA,GAF,HD,HD_5 k59_357326_1 159087.Daro_1189 3.28e-51 171.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,2KW9T@206389|Rhodocyclales 206389|Rhodocyclales S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase k59_357326_2 159087.Daro_1190 2.18e-42 144.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,2KVCY@206389|Rhodocyclales 206389|Rhodocyclales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_371_1 614083.AWQR01000014_gene2477 1.22e-85 273.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,4AAGE@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_714899_1 1000565.METUNv1_04051 1.38e-18 82.8 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales 206389|Rhodocyclales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_714899_2 1000565.METUNv1_04050 6.93e-109 317.0 COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales 206389|Rhodocyclales H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_821807_1 1000565.METUNv1_02057 4.01e-124 370.0 COG1132@1|root,COG1132@2|Bacteria,1NU64@1224|Proteobacteria,2VZ6D@28216|Betaproteobacteria,2KY8F@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_1072102_1 1000565.METUNv1_00414 9.09e-11 61.2 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KUMQ@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_1072102_2 1131814.JAFO01000001_gene4630 7.99e-19 84.3 COG0727@1|root,COG0727@2|Bacteria,1RCAS@1224|Proteobacteria,2U68A@28211|Alphaproteobacteria,3F1JW@335928|Xanthobacteraceae 28211|Alphaproteobacteria S PFAM Uncharacterised protein family (UPF0153) - - - - - - - - - - - - CxxCxxCC k59_322520_1 159087.Daro_0232 1.84e-68 231.0 COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07677,ko:K07679,ko:K11527,ko:K20974 ko02020,ko02025,ko02026,ko05133,map02020,map02025,map02026,map05133 M00474,M00477,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_750339_2 522306.CAP2UW1_3170 6.02e-41 147.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria 28216|Betaproteobacteria L RNA-directed DNA polymerase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,Intron_maturas2,RVT_1 k59_72143_1 1000565.METUNv1_02705 4.77e-157 470.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVF1@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_964461_1 1000565.METUNv1_00396 3.92e-202 579.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,2KVHX@206389|Rhodocyclales 206389|Rhodocyclales C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1107338_1 640081.Dsui_1271 1.42e-21 98.2 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,2KV1S@206389|Rhodocyclales 206389|Rhodocyclales D peptidase, M23 - - - - - - - - - - - - Peptidase_M23 k59_357996_1 342610.Patl_0859 7e-12 64.7 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,1S0S0@1236|Gammaproteobacteria,2Q3IG@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C FAD binding domain - - 1.14.13.218 ko:K20940 ko00405,ko01130,map00405,map01130 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_357996_2 1232683.ADIMK_2587 1.22e-70 217.0 COG0662@1|root,COG0662@2|Bacteria,1QU63@1224|Proteobacteria,1T2PT@1236|Gammaproteobacteria 1236|Gammaproteobacteria G PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_928613_1 1123037.AUDE01000021_gene2159 4.35e-13 77.4 COG4935@1|root,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia 976|Bacteroidetes O Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - CHU_C,P_proprotein,Reprolysin_4,TSP_3 k59_643815_1 85643.Tmz1t_2545 1.92e-22 94.7 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,2KVDB@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_643815_2 1000565.METUNv1_01120 2.91e-180 528.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,2KVN8@206389|Rhodocyclales 206389|Rhodocyclales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_857315_1 1000565.METUNv1_02024 1.05e-25 103.0 COG0438@1|root,COG0438@2|Bacteria,1NE5D@1224|Proteobacteria,2VWY9@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_250820_1 1000565.METUNv1_01179 4.45e-267 744.0 COG2204@1|root,COG2204@2|Bacteria,1QVPI@1224|Proteobacteria,2WHXV@28216|Betaproteobacteria 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg,TPR_16 k59_250820_4 740709.A10D4_10641 4.13e-10 59.7 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,2QEYA@267893|Idiomarinaceae 1236|Gammaproteobacteria K the result is increased expression of ompC and repression of ompF ompR GO:0000156,GO:0000160,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0035556,GO:0043565,GO:0044212,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_393680_1 1502852.FG94_00568 7.35e-45 153.0 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,472W5@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF882) - - - - - - - - - - - - Peptidase_M15_2 k59_928615_1 1000565.METUNv1_02975 4.79e-28 118.0 COG1566@1|root,COG1566@2|Bacteria,1QVR9@1224|Proteobacteria,2W3A9@28216|Betaproteobacteria 28216|Betaproteobacteria V Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_4 k59_643826_2 1288494.EBAPG3_1010 0.000178 48.9 COG3211@1|root,COG3211@2|Bacteria,1R690@1224|Proteobacteria,2VMQX@28216|Betaproteobacteria,3725Y@32003|Nitrosomonadales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,VPEP k59_1036059_1 1144319.PMI16_03274 5.69e-83 251.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,472P7@75682|Oxalobacteraceae 28216|Betaproteobacteria S Small MutS-related domain smrA - - - - - - - - - - - Smr k59_72157_1 204773.HEAR2963 1.34e-76 248.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2VHP6@28216|Betaproteobacteria,4724W@75682|Oxalobacteraceae 28216|Betaproteobacteria M TonB dependent receptor phuR - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_643834_1 1121456.ATVA01000014_gene632 1.14e-07 53.1 COG1783@1|root,COG1783@2|Bacteria,1RAGC@1224|Proteobacteria,42Z29@68525|delta/epsilon subdivisions,2WTUP@28221|Deltaproteobacteria,2MCJK@213115|Desulfovibrionales 28221|Deltaproteobacteria S phage Terminase large subunit - - - - - - - - - - - - - k59_465005_1 1148.1653075 5.46e-21 99.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3300@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG3300@2|Bacteria,1GPYK@1117|Cyanobacteria,1H507@1142|Synechocystis 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_4,PAS_9,PHY,Response_reg k59_393689_1 56107.Cylst_1563 1.66e-24 98.6 COG4446@1|root,COG4446@2|Bacteria,1G6W2@1117|Cyanobacteria,1HNRG@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_750358_1 614083.AWQR01000001_gene3114 4.77e-05 45.1 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ACGH@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_750358_2 358220.C380_03380 1.44e-72 230.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ACGH@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_928616_1 1000565.METUNv1_00886 8.32e-248 696.0 COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VHXV@28216|Betaproteobacteria,2KVPM@206389|Rhodocyclales 206389|Rhodocyclales EH COG0147 Anthranilate para-aminobenzoate synthases component I pabB - 2.6.1.85,4.1.3.38 ko:K03342 ko00790,map00790 - R01716,R05553 RC00010,RC01418,RC01843,RC02148 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4,Chorismate_bind k59_107904_1 1000565.METUNv1_01431 5.22e-07 50.4 COG1918@1|root,COG1918@2|Bacteria 2|Bacteria P iron ion homeostasis feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_250837_2 1454004.AW11_01632 2.35e-49 177.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1KPVM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1072161_1 1116472.MGMO_115c00230 2.08e-87 276.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1XEHG@135618|Methylococcales 135618|Methylococcales F Belongs to the 5'-nucleotidase family - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_857334_1 296591.Bpro_1338 5.68e-79 243.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,4A9Q3@80864|Comamonadaceae 28216|Betaproteobacteria T protein phosphatase 2C domain protein pphA - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_107911_1 1000565.METUNv1_01604 6.53e-122 359.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVV3@206389|Rhodocyclales 206389|Rhodocyclales T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_643848_1 497321.C664_04986 3.34e-126 367.0 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,2VI3P@28216|Betaproteobacteria,2KUKX@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase dnaL - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_643848_2 1000565.METUNv1_03279 9.05e-100 291.0 COG2110@1|root,COG2110@2|Bacteria,1MVYN@1224|Proteobacteria,2VH7H@28216|Betaproteobacteria 28216|Betaproteobacteria S Appr-1-p processing - - - - - - - - - - - - Macro k59_643848_3 1000565.METUNv1_03280 1.1e-134 387.0 COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2VSJD@28216|Betaproteobacteria,2KW55@206389|Rhodocyclales 206389|Rhodocyclales I acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_643848_4 1000565.METUNv1_03281 1.82e-16 76.3 COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2VH4B@28216|Betaproteobacteria,2KU7J@206389|Rhodocyclales 206389|Rhodocyclales S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_1000322_1 1000565.METUNv1_00742 1.67e-131 399.0 COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria,2KV4B@206389|Rhodocyclales 206389|Rhodocyclales U Bacterial type II/III secretion system short domain - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - STN,Secretin,Secretin_N k59_1000322_2 1000565.METUNv1_00743 1.64e-55 173.0 COG2944@1|root,COG2944@2|Bacteria,1N48U@1224|Proteobacteria,2VUHQ@28216|Betaproteobacteria,2KWYQ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 k59_465027_1 350058.Mvan_5172 4.94e-80 253.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,2338P@1762|Mycobacteriaceae 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.44 ko:K00666,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_286612_1 596151.DesfrDRAFT_3235 5.98e-06 55.5 COG0642@1|root,COG3452@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3452@2|Bacteria,COG3829@2|Bacteria,1N6GE@1224|Proteobacteria,43D2R@68525|delta/epsilon subdivisions,2WUT1@28221|Deltaproteobacteria,2M913@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_4,PAS_9 k59_72176_1 1000565.METUNv1_01364 9.6e-135 412.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KURD@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07239 - - - - ko00000 2.A.6.1 - - ACR_tran k59_358055_1 485918.Cpin_1632 2.87e-98 288.0 COG0098@1|root,COG0098@2|Bacteria,4NG1Z@976|Bacteroidetes,1IQ9B@117747|Sphingobacteriia 976|Bacteroidetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_678961_1 365044.Pnap_1957 7.12e-32 123.0 COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,4AGRG@80864|Comamonadaceae 28216|Betaproteobacteria IJ Formyl transferase hoxX - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N k59_678961_2 1000565.METUNv1_03207 8.08e-214 599.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUEY@206389|Rhodocyclales 206389|Rhodocyclales T Bacterial regulatory protein, Fis family hoxA - - ko:K19641 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_322603_1 395495.Lcho_4114 1.07e-128 379.0 COG3292@1|root,COG3292@2|Bacteria,1N0TN@1224|Proteobacteria,2VMZM@28216|Betaproteobacteria,1KNDQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_322603_2 748247.AZKH_0320 2.19e-119 355.0 COG3292@1|root,COG3292@2|Bacteria,1QU1S@1224|Proteobacteria,2VPDV@28216|Betaproteobacteria 28216|Betaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_536180_1 1000565.METUNv1_00612 3.69e-114 334.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,2KVMS@206389|Rhodocyclales 206389|Rhodocyclales OU signal peptide peptidase - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_536180_2 1000565.METUNv1_00613 2.79e-72 223.0 COG0313@1|root,COG0313@2|Bacteria,1RARW@1224|Proteobacteria,2VQ34@28216|Betaproteobacteria,2KW5K@206389|Rhodocyclales 206389|Rhodocyclales H Uroporphyrin-III C tetrapyrrole - - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_107924_1 1000565.METUNv1_00671 7.24e-118 343.0 COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,2KVYR@206389|Rhodocyclales 206389|Rhodocyclales M of murein hydrolase - - - - - - - - - - - - LrgB k59_821860_1 1149133.ppKF707_5001 6.09e-62 194.0 COG0789@1|root,COG0789@2|Bacteria,1RGW6@1224|Proteobacteria,1S6HG@1236|Gammaproteobacteria,1YGMX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_465038_1 640081.Dsui_2885 8.62e-60 208.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg k59_358061_1 1000565.METUNv1_00041 2.6e-237 670.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,2KUWP@206389|Rhodocyclales 206389|Rhodocyclales O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_3 k59_107929_2 395495.Lcho_0243 1.36e-50 176.0 COG3851@1|root,COG3851@2|Bacteria,1QUAD@1224|Proteobacteria,2WHPU@28216|Betaproteobacteria,1KPMH@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3 k59_1107393_1 1158292.JPOE01000005_gene738 6.15e-16 75.9 COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,1NEHF@1224|Proteobacteria,2VNNV@28216|Betaproteobacteria,1KNQR@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Pfam:DUF955 - - - - - - - - - - - - HTH_3,Peptidase_M78 k59_1107393_2 1158292.JPOE01000005_gene737 7.15e-123 352.0 COG5340@1|root,COG5340@2|Bacteria,1P6MT@1224|Proteobacteria,2VPJY@28216|Betaproteobacteria,1KNS0@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_1,AbiEi_3_N,AbiEi_4 k59_501099_1 483216.BACEGG_01561 2.95e-18 87.8 COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,4NFDB@976|Bacteroidetes,2FPXJ@200643|Bacteroidia,4ANIW@815|Bacteroidaceae 976|Bacteroidetes M Nucleotidyl transferase gmhB - 2.7.7.71 ko:K15669 ko00540,map00540 - R09772 RC00002 ko00000,ko00001,ko01000 - - - CBS,NTP_transferase k59_501099_2 1392487.JIAD01000001_gene1365 1.47e-05 47.8 COG0110@1|root,COG0110@2|Bacteria,1V2RI@1239|Firmicutes,24GV6@186801|Clostridia,25WPQ@186806|Eubacteriaceae 186801|Clostridia S sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family - - - - - - - - - - - - Hexapep,Hexapep_2 k59_786399_1 388051.AUFE01000004_gene856 1.46e-39 147.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2VIAB@28216|Betaproteobacteria,1K06D@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA ligase ligD - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_786399_2 932677.PAJ_0999 4.82e-25 95.5 COG4572@1|root,COG4572@2|Bacteria,1N93H@1224|Proteobacteria,1S94E@1236|Gammaproteobacteria,3W15I@53335|Pantoea 1236|Gammaproteobacteria S In Escherichia coli this protein putatively regulates the sodium proton (also pH-independent calcium proton) antiporter chaA chaB - - ko:K06197 - - - - ko00000 - - - ChaB k59_786399_3 1403819.BATR01000016_gene484 8.33e-84 256.0 COG1028@1|root,COG1028@2|Bacteria,46SN5@74201|Verrucomicrobia,2IUJB@203494|Verrucomicrobiae 203494|Verrucomicrobiae IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_714998_1 1121939.L861_09600 4.1e-11 62.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XHT9@135619|Oceanospirillales 135619|Oceanospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_714998_2 1122951.ATUE01000013_gene1517 2.13e-107 322.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,3NIRD@468|Moraxellaceae 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_322618_2 1000565.METUNv1_03659 4e-121 358.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,2KUM9@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_286635_1 1000565.METUNv1_00387 4.66e-129 370.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,2KUH7@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_678965_1 1000565.METUNv1_02489 1.56e-216 616.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - DUF2222,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_678965_2 1000565.METUNv1_02488 4e-147 421.0 COG2984@1|root,COG2984@2|Bacteria,1NACH@1224|Proteobacteria,2VSU8@28216|Betaproteobacteria,2KWT6@206389|Rhodocyclales 206389|Rhodocyclales S transport system, periplasmic component - - - - - - - - - - - - ABC_sub_bind k59_1036101_2 653733.Selin_0873 1.58e-61 203.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - ko:K07257 - - - - ko00000 - - - Aldo_ket_red k59_1036101_3 1163617.SCD_n02906 5.55e-190 537.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_1036101_4 1163617.SCD_n02907 1.02e-216 600.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2VHGF@28216|Betaproteobacteria 28216|Betaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_2 k59_1036101_5 1000565.METUNv1_03520 6.79e-26 106.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,2VMV8@28216|Betaproteobacteria,2KVSP@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_501113_1 1380387.JADM01000006_gene1070 1.54e-84 260.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1XHVA@135619|Oceanospirillales 135619|Oceanospirillales C Converts isocitrate to alpha ketoglutarate icdA - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_786410_1 232721.Ajs_2205 5.04e-108 317.0 COG1502@1|root,COG1502@2|Bacteria,1NXTE@1224|Proteobacteria,2VNR4@28216|Betaproteobacteria,4AG8V@80864|Comamonadaceae 28216|Betaproteobacteria I Phospholipase D Active site motif - - - - - - - - - - - - PLDc_2 k59_187500_1 477184.KYC_22251 2.31e-53 177.0 COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,2VHF0@28216|Betaproteobacteria,3T8N0@506|Alcaligenaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_437602_1 637905.SVI_0574 6.45e-28 112.0 COG1232@1|root,COG1232@2|Bacteria,1QZ0K@1224|Proteobacteria 1224|Proteobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_437602_2 1005048.CFU_0764 6.47e-34 125.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,473PP@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_827521_1 1123367.C666_08930 5.34e-61 203.0 COG0419@1|root,COG0419@2|Bacteria,1N7NZ@1224|Proteobacteria,2VHJG@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain - - - ko:K19171 - - - - ko00000,ko02048 - - - AAA_23 k59_827521_2 1123367.C666_08935 9.37e-61 187.0 arCOG09464@1|root,307RI@2|Bacteria,1N4HH@1224|Proteobacteria 1224|Proteobacteria S DNA sulfur modification protein DndE - - - ko:K19172 - - - - ko00000,ko02048 - - - DndE k59_827523_1 1268622.AVS7_03878 9.9e-100 293.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,4A9QD@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family phbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_256422_1 1000565.METUNv1_03875 1.75e-281 851.0 COG3210@1|root,COG3210@2|Bacteria,1QDZF@1224|Proteobacteria,2VPRR@28216|Betaproteobacteria,2KZTG@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Haemagg_act k59_399653_1 1000565.METUNv1_01929 1.37e-246 686.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,2KUJD@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_399653_2 1000565.METUNv1_01928 3.56e-41 135.0 2EPEP@1|root,33H1B@2|Bacteria,1NHDJ@1224|Proteobacteria,2VXNY@28216|Betaproteobacteria,2KZUH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3460) - - - - - - - - - - - - DUF3460 k59_399653_3 1000565.METUNv1_01927 8.4e-103 319.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_147794_1 1097668.BYI23_B004770 2.15e-34 138.0 28IJ1@1|root,2Z8K0@2|Bacteria,1R5PC@1224|Proteobacteria,2W0IK@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_899209_1 1073999.BN137_3369 1.34e-118 361.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1RPS2@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_719735_1 755732.Fluta_0087 1.19e-45 168.0 COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia,2PBEH@246874|Cryomorphaceae 976|Bacteroidetes M SPTR CHU large protein - - - - - - - - - - - - CHU_C,PKD,SprB,TIG k59_292640_1 338969.Rfer_3659 4.42e-39 140.0 COG2271@1|root,COG2271@2|Bacteria,1QZ70@1224|Proteobacteria,2WHIE@28216|Betaproteobacteria 28216|Betaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_292640_2 517433.PanABDRAFT_0047 1.45e-19 86.3 COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S4E5@1236|Gammaproteobacteria,3W03V@53335|Pantoea 1236|Gammaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_399662_1 335283.Neut_2536 1.31e-07 58.5 2BSN5@1|root,32MQR@2|Bacteria,1MYG6@1224|Proteobacteria,2VVN3@28216|Betaproteobacteria 28216|Betaproteobacteria S Plasmid replication region DNA-binding N-term - - - - - - - - - - - - KfrA_N k59_508946_1 1000565.METUNv1_02293 6.25e-131 374.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2VIR0@28216|Betaproteobacteria,2KU98@206389|Rhodocyclales 206389|Rhodocyclales EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_651987_1 1000565.METUNv1_02521 2.69e-271 749.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,2KXTE@206389|Rhodocyclales 206389|Rhodocyclales C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S k59_77842_1 1000565.METUNv1_00922 3.06e-140 407.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,2KUM2@206389|Rhodocyclales 206389|Rhodocyclales S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC k59_791758_1 866536.Belba_0225 1.17e-23 97.8 COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,47K34@768503|Cytophagia 976|Bacteroidetes H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1005933_1 1000565.METUNv1_02471 2.77e-80 248.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,2KVN9@206389|Rhodocyclales 206389|Rhodocyclales S Permease YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1005933_2 1000565.METUNv1_02472 9.64e-150 429.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,2KUBZ@206389|Rhodocyclales 206389|Rhodocyclales S Permease YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_791761_1 338969.Rfer_3430 1.25e-69 227.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,4AA27@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_540577_1 1121920.AUAU01000018_gene1801 6.44e-102 305.0 COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria 57723|Acidobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1111369_1 614083.AWQR01000011_gene2320 5.16e-115 355.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,4AA22@80864|Comamonadaceae 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_147827_1 1000565.METUNv1_02451 7.31e-87 278.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_147827_2 1000565.METUNv1_02452 6.25e-151 428.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KUQG@206389|Rhodocyclales 206389|Rhodocyclales T Serine/threonine phosphatases, family 2C, catalytic domain pppL - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_1080371_2 543728.Vapar_4677 6.3e-75 225.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria,4ADIJ@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1080374_1 1209072.ALBT01000032_gene2110 2.71e-44 163.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1FIIZ@10|Cellvibrio 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_861647_1 925409.KI911562_gene1224 1.41e-75 235.0 COG2255@1|root,COG2255@2|Bacteria,4NEB9@976|Bacteroidetes,1IR3Y@117747|Sphingobacteriia 976|Bacteroidetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_652034_1 1000565.METUNv1_01282 4.38e-25 99.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,2KUKC@206389|Rhodocyclales 206389|Rhodocyclales P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_652034_2 1000565.METUNv1_01283 2.49e-158 453.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2WGQX@28216|Betaproteobacteria,2KZWD@206389|Rhodocyclales 206389|Rhodocyclales E ATPases associated with a variety of cellular activities - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran k59_1005967_1 1003200.AXXA_28025 1.09e-62 207.0 COG0507@1|root,COG5362@1|root,COG0507@2|Bacteria,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2W8BI@28216|Betaproteobacteria,3T6FT@506|Alcaligenaceae 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_470342_1 243231.GSU0064 7.06e-29 118.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,42N7I@68525|delta/epsilon subdivisions,2WJG8@28221|Deltaproteobacteria,43TS1@69541|Desulfuromonadales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_861659_1 1122603.ATVI01000005_gene3252 3.65e-49 177.0 COG0382@1|root,COG0392@1|root,COG0382@2|Bacteria,COG0392@2|Bacteria,1MXCM@1224|Proteobacteria,1RRWB@1236|Gammaproteobacteria,1X353@135614|Xanthomonadales 135614|Xanthomonadales H UbiA prenyltransferase family - - - - - - - - - - - - HAD,UbiA k59_187637_1 1000565.METUNv1_02983 7.39e-106 311.0 COG2972@1|root,COG2972@2|Bacteria,1QYRK@1224|Proteobacteria,2WHJ2@28216|Betaproteobacteria 28216|Betaproteobacteria T Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365,HAMP k59_77889_1 1000565.METUNv1_00228 2.77e-146 419.0 28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2VMSI@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_77889_2 1000565.METUNv1_00229 1.95e-96 285.0 COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQ4T@28216|Betaproteobacteria,2KWHY@206389|Rhodocyclales 206389|Rhodocyclales Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_77889_3 1000565.METUNv1_00230 2.05e-51 167.0 COG2050@1|root,COG2050@2|Bacteria,1RHP8@1224|Proteobacteria,2VWKH@28216|Betaproteobacteria 28216|Betaproteobacteria Q Thioesterase superfamily protein - - - - - - - - - - - - 4HBT k59_77889_4 1000565.METUNv1_00231 1.34e-49 160.0 COG2329@1|root,COG2329@2|Bacteria,1N062@1224|Proteobacteria,2VUQE@28216|Betaproteobacteria,2KYZ3@206389|Rhodocyclales 206389|Rhodocyclales S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_77889_5 375286.mma_1410 2.05e-27 104.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,47419@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_363553_1 1504672.669785519 5.93e-07 49.7 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2VT72@28216|Betaproteobacteria,4AED9@80864|Comamonadaceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_363553_2 1504672.669785518 2.09e-82 251.0 COG3821@1|root,COG3821@2|Bacteria,1PPR3@1224|Proteobacteria,2VR42@28216|Betaproteobacteria,4AHJE@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function, DUF599 - - - - - - - - - - - - DUF599 k59_363553_3 1000565.METUNv1_02342 2.18e-15 71.2 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,2KWFN@206389|Rhodocyclales 206389|Rhodocyclales O Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_510697_1 1387312.BAUS01000004_gene1609 3.87e-20 91.7 COG0642@1|root,COG3300@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3300@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KKHS@206350|Nitrosomonadales 206350|Nitrosomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MHYT,PAS_3,PAS_9,Response_reg k59_78967_1 1000565.METUNv1_01406 4.13e-120 353.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,2KUC4@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_78967_2 243233.MCA0112 2.13e-15 72.4 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,1RPVD@1236|Gammaproteobacteria,1XDQ3@135618|Methylococcales 135618|Methylococcales C PFAM Inorganic pyrophosphatase ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_653829_1 614083.AWQR01000003_gene2933 1.51e-118 362.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,4AA3D@80864|Comamonadaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_684012_1 398578.Daci_0606 2.67e-07 52.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJIY@28216|Betaproteobacteria,4AD77@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family vioA - 2.6.1.33 ko:K20429 - - R02773 RC00006,RC00781 ko00000,ko01000 - - - DegT_DnrJ_EryC1 k59_684012_2 561230.PC1_2569 1.78e-26 112.0 COG0457@1|root,COG3914@1|root,COG4797@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,COG4797@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria,1MSJH@122277|Pectobacterium 1236|Gammaproteobacteria O Predicted methyltransferase regulatory domain - - - - - - - - - - - - Glyco_transf_41,MethyTransf_Reg,Methyltransf_12,Methyltransf_25,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_755411_1 700598.Niako_6932 5.21e-50 168.0 COG3170@1|root,COG3170@2|Bacteria,4NF47@976|Bacteroidetes,1IS3D@117747|Sphingobacteriia 976|Bacteroidetes NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_471369_1 614083.AWQR01000002_gene3009 1.18e-62 216.0 COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria,4ACV5@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_653862_2 89187.ISM_14390 1.02e-14 76.3 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,46NBR@74030|Roseovarius 28211|Alphaproteobacteria C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_755412_1 761193.Runsl_2717 3.32e-42 139.0 2EGEP@1|root,33A6N@2|Bacteria,4NXT1@976|Bacteroidetes,47T7P@768503|Cytophagia 976|Bacteroidetes - - - - 5.3.3.4 ko:K03464 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R06990 RC01109 ko00000,ko00001,ko00002,ko01000 - - - MIase k59_510737_1 1219031.BBJR01000074_gene942 1.37e-07 52.8 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,4ADP4@80864|Comamonadaceae 28216|Betaproteobacteria L Methyltransferase rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_510737_2 1458427.BAWN01000004_gene170 2.8e-75 229.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,4ABJ9@80864|Comamonadaceae 28216|Betaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_969671_1 743299.Acife_1622 1.26e-36 140.0 COG1231@1|root,COG1231@2|Bacteria,1P3D9@1224|Proteobacteria,1S0H2@1236|Gammaproteobacteria,2ND3H@225057|Acidithiobacillales 225057|Acidithiobacillales E Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_541466_1 104623.Ser39006_00639 4.22e-52 174.0 COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,1RNG0@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_541466_2 614083.AWQR01000007_gene407 1.22e-67 213.0 COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VTZB@28216|Betaproteobacteria 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_257545_1 1000565.METUNv1_00044 2.42e-115 342.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2VH5S@28216|Betaproteobacteria,2KVN3@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1112244_1 1123257.AUFV01000003_gene1135 2.12e-85 261.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,1X4RN@135614|Xanthomonadales 135614|Xanthomonadales I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_828934_1 1198452.Jab_1c13560 3.69e-68 217.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,472CB@75682|Oxalobacteraceae 28216|Betaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_720765_1 62928.azo3097 2.37e-92 291.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,2KUMB@206389|Rhodocyclales 206389|Rhodocyclales P Von Willebrand factor type A norD - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA k59_720765_2 1123487.KB892868_gene1285 5.47e-70 221.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,2KUQN@206389|Rhodocyclales 206389|Rhodocyclales K Crp Fnr family transcriptional regulator - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_720765_3 1000565.METUNv1_03876 1.99e-55 178.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,2KVAG@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases nnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_862803_1 1484460.JSWG01000009_gene32 6.54e-30 119.0 28IZ7@1|root,2Z8WQ@2|Bacteria,4NIAK@976|Bacteroidetes,1I09F@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_293908_2 349163.Acry_2508 3.9e-59 199.0 2DUCN@1|root,33PZW@2|Bacteria,1NTHY@1224|Proteobacteria 1224|Proteobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_510789_1 1177181.T9A_03074 8.23e-63 197.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1XH7Z@135619|Oceanospirillales 135619|Oceanospirillales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding k59_510789_2 519989.ECTPHS_06347 2.19e-24 94.7 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1WY24@135613|Chromatiales 135613|Chromatiales O redox protein, regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC k59_576880_1 1000565.METUNv1_01367 1.44e-64 210.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria,2KUCC@206389|Rhodocyclales 206389|Rhodocyclales M COG0845 Membrane-fusion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_1082325_1 1150469.RSPPHO_01651 6.56e-218 658.0 COG0642@1|root,COG3829@1|root,COG5002@1|root,COG0642@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TZDS@28211|Alphaproteobacteria,2JZ03@204441|Rhodospirillales 204441|Rhodospirillales T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_189458_1 338969.Rfer_0064 4.59e-70 230.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4A9RM@80864|Comamonadaceae 28216|Betaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_653961_1 1000565.METUNv1_00821 1.09e-186 536.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_510831_1 1198452.Jab_1c17460 2.64e-65 206.0 2DTTH@1|root,33MJW@2|Bacteria,1NGH2@1224|Proteobacteria 1198452.Jab_1c17460|- - - - - - - - - - - - - - - - k59_1112279_1 1000565.METUNv1_01930 2.18e-226 647.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KYB2@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9,Response_reg k59_933873_1 1198452.Jab_2c30370 3.66e-25 101.0 COG0834@1|root,COG0834@2|Bacteria,1RH2S@1224|Proteobacteria,2VTUM@28216|Betaproteobacteria,475PR@75682|Oxalobacteraceae 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_828982_1 196367.JNFG01000020_gene4674 1.18e-83 256.0 COG0596@1|root,COG0596@2|Bacteria,1RB3Q@1224|Proteobacteria,2WEMP@28216|Betaproteobacteria 28216|Betaproteobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_933874_1 1116472.MGMO_11c00060 1.67e-118 355.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,1XE5J@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_1042689_1 1238182.C882_0939 1.06e-42 150.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,2JSD0@204441|Rhodospirillales 204441|Rhodospirillales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_471436_1 1157708.KB907456_gene2339 2.37e-81 248.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,4AA9M@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the BI1 family yccA - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_79053_1 261292.Nit79A3_1754 4.52e-06 47.4 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,3733D@32003|Nitrosomonadales 28216|Betaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_653973_1 1000565.METUNv1_03772 1.72e-93 281.0 COG1216@1|root,COG1216@2|Bacteria,1R1SJ@1224|Proteobacteria 1224|Proteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - - k59_576900_1 1000565.METUNv1_02447 1.61e-130 379.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,2KV9X@206389|Rhodocyclales 206389|Rhodocyclales F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1055811_1 614083.AWQR01000006_gene261 4.8e-78 240.0 2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,2VS4A@28216|Betaproteobacteria,4ADQE@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_268926_2 925409.KI911562_gene2667 2.61e-23 98.6 COG0414@1|root,COG0414@2|Bacteria,4NFT9@976|Bacteroidetes,1IQ34@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_228005_2 1101195.Meth11DRAFT_1448 1.41e-17 82.0 COG4772@1|root,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,2WGQ6@28216|Betaproteobacteria,2KPAY@206350|Nitrosomonadales 206350|Nitrosomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1017279_1 443152.MDG893_20454 2.08e-48 167.0 COG2207@1|root,COG2207@2|Bacteria,1RENI@1224|Proteobacteria,1S6HJ@1236|Gammaproteobacteria,46B8M@72275|Alteromonadaceae 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_979748_2 748247.AZKH_4592 8.32e-51 164.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding - - - - - - - - - - - - PBP_like_2 k59_160628_1 1003200.AXXA_27995 1.34e-42 149.0 2AXQF@1|root,31PR8@2|Bacteria,1RKX8@1224|Proteobacteria,2W377@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_552730_2 59538.XP_005966935.1 3.52e-45 164.0 COG0415@1|root,KOG0133@2759|Eukaryota,38BKX@33154|Opisthokonta,3B995@33208|Metazoa,3CX0G@33213|Bilateria,480B2@7711|Chordata,48ZHT@7742|Vertebrata,3J7G6@40674|Mammalia,4IWA6@91561|Cetartiodactyla 33208|Metazoa LT Cryptochrome circadian clock 2 - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_349348_1 1122951.ATUE01000005_gene1875 6.05e-117 349.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,3NJ0F@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_764450_1 1122135.KB893146_gene1487 1.02e-18 84.0 COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH sulfate adenylyltransferase subunit 2 cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_764450_2 765913.ThidrDRAFT_0505 5.62e-12 66.2 COG1682@1|root,COG1682@2|Bacteria,1MWG4@1224|Proteobacteria,1S11D@1236|Gammaproteobacteria,1WXF5@135613|Chromatiales 135613|Chromatiales GM PFAM ABC-2 type transporter - - - ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 - - ABC2_membrane k59_456919_1 1502852.FG94_01049 1.38e-05 52.8 COG2203@1|root,COG3292@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,475JP@75682|Oxalobacteraceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Reg_prop,Y_Y_Y k59_585463_1 1100721.ALKO01000036_gene2739 9.61e-33 117.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,4AA9Y@80864|Comamonadaceae 28216|Betaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_585463_2 365046.Rta_15380 2.1e-84 255.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ6F@28216|Betaproteobacteria,4A9WZ@80864|Comamonadaceae 28216|Betaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_456925_1 1502852.FG94_04477 5.16e-09 56.2 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2VNAZ@28216|Betaproteobacteria,473PB@75682|Oxalobacteraceae 28216|Betaproteobacteria JM Nucleotidyl transferase - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_456925_2 1266925.JHVX01000005_gene1985 5.17e-38 137.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,372GG@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM NAD-dependent epimerase dehydratase galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_206173_1 296591.Bpro_2193 1.17e-65 212.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,4AB3M@80864|Comamonadaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_206173_2 614083.AWQR01000031_gene2671 1.97e-39 132.0 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,4AF4Z@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_268960_1 614083.AWQR01000010_gene1601 3.35e-67 212.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VMR5@28216|Betaproteobacteria,4ABTE@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_268960_2 257310.BB1390 2.99e-19 83.2 COG0454@1|root,COG0456@2|Bacteria,1RH71@1224|Proteobacteria,2VTSP@28216|Betaproteobacteria,3T7F3@506|Alcaligenaceae 28216|Betaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_585478_1 1000565.METUNv1_01398 6.51e-98 290.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,2KU7X@206389|Rhodocyclales 206389|Rhodocyclales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_585478_2 1000565.METUNv1_01399 4.84e-12 60.8 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KXCI@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_804497_1 1000565.METUNv1_03785 3.27e-49 184.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria,2KV97@206389|Rhodocyclales 206389|Rhodocyclales NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_306309_1 987059.RBXJA2T_00744 5.79e-37 133.0 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,2VH23@28216|Betaproteobacteria,1KIZ9@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Belongs to the UPF0246 family yaaA - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_306309_2 1458357.BG58_16195 3.38e-65 204.0 COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VQUA@28216|Betaproteobacteria,1K6XY@119060|Burkholderiaceae 28216|Betaproteobacteria KT SMART metal-dependent phosphohydrolase, HD region - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - HD_4 k59_979790_1 1458427.BAWN01000005_gene308 7.87e-75 236.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,4AB52@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_306318_1 393595.ABO_1755 1.67e-42 146.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales 135619|Oceanospirillales IQ reductase - - - - - - - - - - - - adh_short k59_124503_1 1182590.BN5_00974 1.35e-29 115.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1YIXM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Cold shock protein domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_376704_1 338969.Rfer_1648 1.83e-59 190.0 COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,2VQGS@28216|Betaproteobacteria,4ACFV@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0502 family yceH - - ko:K09915 - - - - ko00000 - - - DUF480 k59_376704_2 614083.AWQR01000013_gene1670 2.69e-41 145.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,4A9NJ@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_874407_1 395495.Lcho_0333 1.07e-112 345.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KISZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T chemotaxis sensory transducer - - - ko:K03406,ko:K03776,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS,PAS_3,PAS_8,sCache_2 k59_694417_1 395495.Lcho_4317 3.92e-80 248.0 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2VKTZ@28216|Betaproteobacteria,1KMG2@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_552783_1 1071073.KI530534_gene611 5.17e-69 224.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,1ZB07@1386|Bacillus 91061|Bacilli G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system araG - 3.6.3.17 ko:K10548 ko02010,map02010 M00216 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.5 - - ABC_tran k59_1055921_2 1000565.METUNv1_00803 3.34e-147 440.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales 206389|Rhodocyclales CM Acyl-CoA synthetase (NDP forming) yfiQ - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_206229_1 1005048.CFU_3720 1.15e-26 99.4 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,474HD@75682|Oxalobacteraceae 28216|Betaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_694427_1 1123278.KB893590_gene5410 4.09e-49 177.0 COG2133@1|root,COG3386@1|root,COG4386@1|root,COG2133@2|Bacteria,COG3386@2|Bacteria,COG4386@2|Bacteria,4PNUT@976|Bacteroidetes,47YJ9@768503|Cytophagia 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - NHL k59_585507_2 614083.AWQR01000005_gene1168 1.97e-33 130.0 COG1231@1|root,COG1231@2|Bacteria,1NVGR@1224|Proteobacteria,2VJU0@28216|Betaproteobacteria,4AB24@80864|Comamonadaceae 28216|Betaproteobacteria E Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_482809_1 94122.Shewana3_3089 9.38e-88 274.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,2Q8J1@267890|Shewanellaceae 1236|Gammaproteobacteria E POT family dtpA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680 - ko:K03305 - - - - ko00000 2.A.17 - iB21_1397.B21_01594,iBWG_1329.BWG_1449,iEC042_1314.EC042_1803,iECBD_1354.ECBD_2009,iECB_1328.ECB_01604,iECDH10B_1368.ECDH10B_1768,iECDH1ME8569_1439.ECDH1ME8569_1578,iECD_1391.ECD_01604,iECH74115_1262.ECH74115_4843,iECSP_1301.ECSP_4476,iECUMN_1333.ECUMN_1925,iECs_1301.ECs4368,iETEC_1333.ETEC_1669,iEcDH1_1363.EcDH1_2006,iEcSMS35_1347.EcSMS35_1565,iEcolC_1368.EcolC_1995,iJO1366.b1634,iUMNK88_1353.UMNK88_2094,iY75_1357.Y75_RS08570,iZ_1308.Z4896 PTR2 k59_1055935_1 1267211.KI669560_gene1035 3.23e-104 311.0 COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1IPBP@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1092617_1 1424334.W822_00330 8.79e-100 300.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2VKCE@28216|Betaproteobacteria,3T1U9@506|Alcaligenaceae 28216|Betaproteobacteria C FAD dependent oxidoreductase soxB - 1.4.99.5,1.5.3.1 ko:K00303,ko:K10816 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 - R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 - - - DAO k59_1092617_2 640511.BC1002_3842 4.58e-44 144.0 COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2VU5D@28216|Betaproteobacteria,1K8MN@119060|Burkholderiaceae 28216|Betaproteobacteria E Sarcosine oxidase delta subunit soxD - 1.5.3.1 ko:K00304 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxD k59_88757_1 1278309.KB907101_gene623 8.61e-93 280.0 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,1XHM2@135619|Oceanospirillales 135619|Oceanospirillales P ABC transporter permease oppC - - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_160696_1 1000565.METUNv1_02301 1.06e-65 217.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,2KV1E@206389|Rhodocyclales 206389|Rhodocyclales O COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_206262_1 641149.HMPREF9016_00038 4.9e-84 256.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,2KPSP@206351|Neisseriales 206351|Neisseriales P Binding-protein-dependent transport system inner membrane component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_671627_1 1122951.ATUE01000005_gene2122 6.68e-97 301.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,3NJYU@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_804566_1 700598.Niako_0108 3.12e-93 303.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,4NFKH@976|Bacteroidetes,1IP8F@117747|Sphingobacteriia 976|Bacteroidetes E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1017407_1 1547437.LL06_13525 3.34e-80 263.0 COG2937@1|root,COG2937@2|Bacteria,1QYER@1224|Proteobacteria,2TZA7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the GPAT DAPAT family - - - - - - - - - - - - - k59_694474_1 991.IW20_00705 7.67e-62 201.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,1HXDC@117743|Flavobacteriia,2NTT1@237|Flavobacterium 976|Bacteroidetes I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_694474_2 1123248.KB893348_gene303 4.41e-30 110.0 COG0511@1|root,COG0511@2|Bacteria,4NM8U@976|Bacteroidetes,1ISET@117747|Sphingobacteriia 976|Bacteroidetes I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_124574_1 1500894.JQNN01000001_gene2409 2.81e-13 72.8 COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,2VMS5@28216|Betaproteobacteria,47335@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF898) - - - - - - - - - - - - DUF898 k59_1056011_1 296591.Bpro_3154 1.8e-50 166.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,4AC2Q@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_671654_1 1198452.Jab_1c13540 1.23e-107 315.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,4731B@75682|Oxalobacteraceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_206322_1 1122951.ATUE01000008_gene76 2.67e-124 380.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,3NISD@468|Moraxellaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_124591_1 76114.ebA1212 5.16e-88 277.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,2VH5K@28216|Betaproteobacteria,2KV8U@206389|Rhodocyclales 206389|Rhodocyclales KLT Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090 - - - - ko00000,ko01000 - - - PP2C_2,Pkinase k59_482891_1 1120972.AUMH01000005_gene926 9.36e-25 105.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4HAJN@91061|Bacilli 91061|Bacilli K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_585570_1 391008.Smal_2499 1.26e-07 55.5 29FMF@1|root,302J2@2|Bacteria,1PVG1@1224|Proteobacteria,1T934@1236|Gammaproteobacteria,1XBM2@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_124597_1 580332.Slit_1976 7.01e-65 216.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,44V5I@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_552894_2 1123367.C666_04120 1.62e-37 137.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,2KVGA@206389|Rhodocyclales 206389|Rhodocyclales H COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase - - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_979889_1 1000565.METUNv1_03721 1.25e-94 286.0 COG2946@1|root,COG2946@2|Bacteria,1RDKM@1224|Proteobacteria,2VNHY@28216|Betaproteobacteria,2KX1X@206389|Rhodocyclales 206389|Rhodocyclales L Replication initiation factor - - - - - - - - - - - - Rep_trans k59_160758_1 522306.CAP2UW1_2935 9.08e-17 78.6 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,1KPSH@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_160758_2 395495.Lcho_2218 5.22e-39 132.0 2E33J@1|root,32Y3P@2|Bacteria,1N9JJ@1224|Proteobacteria,2VXE1@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_482906_1 1157708.KB907464_gene495 1.66e-89 282.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4AAAN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_694511_1 338969.Rfer_1385 2.16e-107 322.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,4A9XR@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM peptidase U32 yhbU_1 - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_54017_1 1502852.FG94_02182 1.15e-52 183.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,472DV@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein E, N-terminal domain pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_19341_1 580332.Slit_2162 1.87e-61 215.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_270913_1 243090.RB977 4.47e-50 181.0 COG1228@1|root,COG1228@2|Bacteria,2IYFS@203682|Planctomycetes 203682|Planctomycetes Q COG1228 Imidazolonepropionase and related - - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_410985_1 1000565.METUNv1_00393 2.26e-19 85.9 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KUP4@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_410985_2 1000565.METUNv1_00394 7.76e-75 226.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,2KUI7@206389|Rhodocyclales 206389|Rhodocyclales C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_270921_1 927658.AJUM01000017_gene3072 9.98e-29 119.0 COG0845@1|root,COG0845@2|Bacteria,4NG8S@976|Bacteroidetes,2FMQN@200643|Bacteroidia,3XIS8@558415|Marinilabiliaceae 976|Bacteroidetes M Protein of unknown function (DUF3347) cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23,HlyD_D4 k59_944210_1 1000565.METUNv1_01162 4.67e-166 469.0 COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,2VHF0@28216|Betaproteobacteria,2KV22@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - ko:K03717 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1123418_1 614083.AWQR01000009_gene522 9.23e-60 186.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,4ADJT@80864|Comamonadaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_1123418_2 614083.AWQR01000009_gene523 4.79e-58 180.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,4AEBE@80864|Comamonadaceae 28216|Betaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_321729_3 1121035.AUCH01000016_gene2171 4.77e-53 172.0 COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,2KWQ3@206389|Rhodocyclales 206389|Rhodocyclales S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_428804_1 1000565.METUNv1_00119 7.82e-98 287.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,2KVWJ@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_428804_2 1000565.METUNv1_00118 9.25e-111 323.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,2KWEB@206389|Rhodocyclales 206389|Rhodocyclales S periplasmic or secreted lipoprotein - - - - - - - - - - - - BON k59_321737_1 497321.C664_00175 1.63e-07 51.6 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales 206389|Rhodocyclales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_321737_2 1000565.METUNv1_01315 1.74e-53 177.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,2KYRE@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_464406_1 862908.BMS_3104 3e-29 120.0 COG0399@1|root,COG0535@1|root,COG0399@2|Bacteria,COG0535@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2MURS@213481|Bdellovibrionales,2WITE@28221|Deltaproteobacteria 213481|Bdellovibrionales E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.109 ko:K19715 - - R11395 RC00160 ko00000,ko01000,ko01005 - - - DegT_DnrJ_EryC1 k59_178979_1 1123255.JHYS01000009_gene2307 6.08e-39 137.0 COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,4AAP3@80864|Comamonadaceae 28216|Betaproteobacteria J tRNA rRNA methyltransferase, SpoU spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_178979_2 1123401.JHYQ01000006_gene53 2.85e-17 78.2 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,460NW@72273|Thiotrichales 72273|Thiotrichales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_606975_1 391735.Veis_0778 2.93e-108 342.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4A9T5@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_2 - - ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran k59_285923_1 1000565.METUNv1_03749 4.29e-261 728.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria,2KUAM@206389|Rhodocyclales 206389|Rhodocyclales M Polysaccharide chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_285923_2 1000565.METUNv1_03748 1.48e-127 365.0 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,2VKB3@28216|Betaproteobacteria,2KVHI@206389|Rhodocyclales 206389|Rhodocyclales M COG1596 Periplasmic protein involved in polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export k59_285923_3 1000565.METUNv1_03747 1.33e-199 563.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VKX2@28216|Betaproteobacteria,2KV6R@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_285923_4 1000565.METUNv1_03746 1.15e-143 421.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VP40@28216|Betaproteobacteria,2KUSJ@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_285923_5 1000565.METUNv1_03745 5.23e-137 395.0 COG0476@1|root,COG0476@2|Bacteria,1QUMS@1224|Proteobacteria,2VN2Y@28216|Betaproteobacteria,2KUIK@206389|Rhodocyclales 206389|Rhodocyclales H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 - - - - - - - - - - - - ThiF k59_285923_6 1000565.METUNv1_03744 1.81e-41 148.0 COG0778@1|root,COG0778@2|Bacteria,1PDX3@1224|Proteobacteria,2VNSD@28216|Betaproteobacteria,2KUNZ@206389|Rhodocyclales 206389|Rhodocyclales C Nitroreductase family moeY - - - - - - - - - - - Nitroreductase k59_535678_1 614083.AWQR01000009_gene693 1.15e-83 259.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,4AAX7@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidoglycan-binding LysM - - - - - - - - - - - - LysM k59_856891_1 1000565.METUNv1_02613 8.18e-117 337.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,2VJ1T@28216|Betaproteobacteria,2KUYV@206389|Rhodocyclales 206389|Rhodocyclales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_856891_2 1000565.METUNv1_02612 1.46e-30 114.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,2KVRQ@206389|Rhodocyclales 206389|Rhodocyclales H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_250255_1 1000565.METUNv1_00838 9.03e-102 320.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KV2V@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_999754_2 1349767.GJA_4394 2.11e-59 194.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,472HH@75682|Oxalobacteraceae 28216|Betaproteobacteria E PFAM Peptidase family M20 M25 M40 amaB1 - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_357399_1 1000565.METUNv1_00327 1.24e-229 639.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUM3@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_107401_1 208444.JNYY01000001_gene4746 2.07e-09 59.3 COG1028@1|root,COG1028@2|Bacteria,2I33G@201174|Actinobacteria,4E2A6@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_178991_1 1125973.JNLC01000012_gene913 3.14e-63 206.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,3JUD5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_178991_2 1000565.METUNv1_02514 1.68e-98 290.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria 28216|Betaproteobacteria P Molybdate ABC transporter modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_285933_1 1000565.METUNv1_03671 9.47e-83 280.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_107403_1 536227.CcarbDRAFT_0581 0.00024 46.2 2AE3R@1|root,313WY@2|Bacteria,1V0F3@1239|Firmicutes,24IGF@186801|Clostridia,36MPA@31979|Clostridiaceae 186801|Clostridia S TIR domain - - - - - - - - - - - - TIR_2 k59_893695_1 296591.Bpro_0203 7.11e-98 291.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,4A9UB@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_893695_2 1265502.KB905955_gene459 1.23e-11 62.4 2ASHY@1|root,31HYC@2|Bacteria,1RIM4@1224|Proteobacteria,2VSD6@28216|Betaproteobacteria,4AEK4@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_822173_1 1000565.METUNv1_02651 7.28e-86 271.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,2KVUK@206389|Rhodocyclales 206389|Rhodocyclales N Belongs to the flagella basal body rod proteins family flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_536477_1 90814.KL370891_gene517 2.11e-24 97.1 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,460ET@72273|Thiotrichales 72273|Thiotrichales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_536477_2 1002339.HMPREF9373_0543 1.83e-62 202.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,3NQM0@468|Moraxellaceae 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_251258_1 1205680.CAKO01000040_gene666 2.66e-91 275.0 COG1177@1|root,COG1177@2|Bacteria,1N0SF@1224|Proteobacteria,2TRZ7@28211|Alphaproteobacteria,2JRMV@204441|Rhodospirillales 204441|Rhodospirillales E Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_394111_1 1000565.METUNv1_00364 6.19e-301 824.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KUR5@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_394111_2 1000565.METUNv1_00363 3.54e-63 199.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,2KWC2@206389|Rhodocyclales 206389|Rhodocyclales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_180247_1 1000565.METUNv1_02256 3.67e-188 561.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_501601_1 1380358.JADJ01000007_gene3135 2.17e-13 71.2 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1XN7U@135619|Oceanospirillales 135619|Oceanospirillales E alpha/beta hydrolase fold - - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_501601_2 1121033.AUCF01000001_gene1916 1.03e-28 107.0 2DNH0@1|root,32XFP@2|Bacteria,1N4P7@1224|Proteobacteria,2UE5N@28211|Alphaproteobacteria,2JTGU@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_679249_1 936053.I1BZV7 1.31e-60 214.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta 33154|Opisthokonta G retrotransposable element Tf2 155 kDa protein type 1-like - - - - - - - - - - - - Asp_protease_2,RVT_1,rve k59_715381_1 614083.AWQR01000012_gene1347 2.46e-75 247.0 COG1511@1|root,COG1511@2|Bacteria,1R6MB@1224|Proteobacteria,2VKRK@28216|Betaproteobacteria,4AGFT@80864|Comamonadaceae 28216|Betaproteobacteria S domain protein - - - ko:K01421 - - - - ko00000 - - - ABC2_membrane_3 k59_536481_1 614083.AWQR01000006_gene286 2.01e-48 167.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,4AA4K@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM carboxyl transferase accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_536481_2 398578.Daci_5972 6.02e-71 221.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,4AAYE@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.18 ko:K13766,ko:K15312 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000,ko01008 - - - ECH_1 k59_72459_1 1000565.METUNv1_01529 3.91e-158 459.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,2KUFZ@206389|Rhodocyclales 206389|Rhodocyclales C COG1960 Acyl-CoA dehydrogenases - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_215284_1 395494.Galf_0744 3.49e-77 241.0 COG0551@1|root,COG0551@2|Bacteria,1R81P@1224|Proteobacteria,2VV8R@28216|Betaproteobacteria 28216|Betaproteobacteria L Nuclease-related domain - - - - - - - - - - - - NERD k59_1072724_1 1000565.METUNv1_00393 8.49e-200 558.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KUP4@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_786787_1 3055.AAB93440 3.82e-57 190.0 COG1290@1|root,KOG4663@2759|Eukaryota,37PDF@33090|Viridiplantae,34GP0@3041|Chlorophyta 3041|Chlorophyta C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis cob - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_251283_1 1000565.METUNv1_00274 1.43e-11 62.8 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales 28216|Betaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain epsR - - - - - - - - - - - GerE,Response_reg k59_251283_2 1000565.METUNv1_00273 2.92e-216 615.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - DUF2222,HATPase_c,HisKA,Response_reg,dCache_1 k59_964818_1 987059.RBXJA2T_08260 3.07e-14 66.2 2DNMC@1|root,32Y3R@2|Bacteria,1N8DI@1224|Proteobacteria,2VVNN@28216|Betaproteobacteria,1KMH0@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF2788) - - - - - - - - - - - - DUF2788 k59_964818_2 1000565.METUNv1_00493 2.71e-146 416.0 COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,2KWGH@206389|Rhodocyclales 206389|Rhodocyclales S Predicted integral membrane protein (DUF2189) - - - - - - - - - - - - DUF2189 k59_964818_3 1000565.METUNv1_00492 1.19e-215 615.0 COG0840@1|root,COG0840@2|Bacteria,1MWU2@1224|Proteobacteria,2VNA8@28216|Betaproteobacteria,2KVE4@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - - - - - - - - - - MCPsignal k59_715396_1 614083.AWQR01000007_gene348 7.75e-53 175.0 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,4AA6Q@80864|Comamonadaceae 28216|Betaproteobacteria L May be involved in recombination rdgC - - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_715396_2 397945.Aave_0024 4.6e-24 99.0 2DG9F@1|root,32U6V@2|Bacteria,1N0HX@1224|Proteobacteria,2VTXA@28216|Betaproteobacteria 28216|Betaproteobacteria S LTXXQ motif family protein - - - - - - - - - - - - LTXXQ k59_287004_2 62928.azo2483 5.42e-92 276.0 COG0406@1|root,COG0406@2|Bacteria,1QVCI@1224|Proteobacteria,2WGQ8@28216|Betaproteobacteria,2KW8R@206389|Rhodocyclales 206389|Rhodocyclales G Histidine phosphatase superfamily (branch 1) - - - - - - - - - - - - His_Phos_1 k59_358479_1 985255.APHJ01000021_gene1291 1.74e-51 177.0 COG0577@1|root,COG0577@2|Bacteria,4NFUG@976|Bacteroidetes,1HZ09@117743|Flavobacteriia,2P6EB@244698|Gillisia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_72476_1 1123367.C666_00180 2.66e-82 257.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,2KVNW@206389|Rhodocyclales 206389|Rhodocyclales H Capsular polysaccharide biosynthesis protein CapK - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_893735_1 1123487.KB892864_gene2230 7.72e-102 303.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKC6@28216|Betaproteobacteria,2KYXC@206389|Rhodocyclales 206389|Rhodocyclales G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_358491_1 1123234.AUKI01000011_gene1241 1.73e-44 160.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,4NG2F@976|Bacteroidetes,1HXCP@117743|Flavobacteriia 976|Bacteroidetes G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_465429_1 1090320.KB900605_gene2245 3.79e-51 172.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,2K289@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA thioesterase - - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_822216_2 1434929.X946_690 8.11e-08 56.6 2A7WD@1|root,30WW4@2|Bacteria,1PIMC@1224|Proteobacteria,2W77P@28216|Betaproteobacteria,1KE0Z@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1072747_2 296591.Bpro_4657 2.18e-68 210.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,4AE3J@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose aut - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_430149_1 1236959.BAMT01000012_gene3082 0.000133 43.9 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KNFH@206350|Nitrosomonadales 206350|Nitrosomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_144062_1 666681.M301_2157 9.46e-19 82.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,2KMBR@206350|Nitrosomonadales 206350|Nitrosomonadales F PFAM deoxynucleoside kinase - - - - - - - - - - - - dNK k59_144062_2 583345.Mmol_1886 1.26e-63 202.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,2KKFU@206350|Nitrosomonadales 206350|Nitrosomonadales H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_108295_2 240016.ABIZ01000001_gene1337 1.21e-69 224.0 COG4335@1|root,COG4335@2|Bacteria,46U62@74201|Verrucomicrobia,2IVNE@203494|Verrucomicrobiae 203494|Verrucomicrobiae L DNA alkylation repair - - - - - - - - - - - - DNA_alkylation k59_679287_1 292415.Tbd_1837 5.99e-40 138.0 COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2VTZ3@28216|Betaproteobacteria,1KT83@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_287021_1 1266925.JHVX01000013_gene1629 2.14e-10 62.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2VR4C@28216|Betaproteobacteria,371P7@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_287021_2 521719.ATXQ01000007_gene1153 2.49e-37 139.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1YDS6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008757,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0010340,GO:0016053,GO:0016740,GO:0016741,GO:0016787,GO:0016788,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032259,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0791,iSBO_1134.SBO_0664,iSFV_1184.SFV_0760,iSF_1195.SF0727,iSFxv_1172.SFxv_0792,iSSON_1240.SSON_0756,iS_1188.S0768,iSbBS512_1146.SbBS512_E2575 Methyltransf_11 k59_287021_3 1000565.METUNv1_02241 1.02e-87 268.0 COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,2WHVH@28216|Betaproteobacteria 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 k59_287021_4 1500894.JQNN01000001_gene3552 5.18e-17 80.5 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VH25@28216|Betaproteobacteria,472WQ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_501668_1 1000565.METUNv1_01128 9.23e-49 165.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,2KU6M@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the radical SAM superfamily. PqqE family pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_14,Radical_SAM,SPASM k59_465437_1 614083.AWQR01000023_gene133 2.1e-43 154.0 COG3144@1|root,COG3144@2|Bacteria,1N1NZ@1224|Proteobacteria,2VVFG@28216|Betaproteobacteria,4AF4R@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar hook-length control - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k59_1107698_1 1000565.METUNv1_03335 1.61e-54 173.0 COG1661@1|root,COG1661@2|Bacteria,1RIME@1224|Proteobacteria,2VTIC@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF296) - - - ko:K06934 - - - - ko00000 - - - DUF296 k59_358504_1 580332.Slit_0708 1.3e-53 184.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,44VEJ@713636|Nitrosomonadales 28216|Betaproteobacteria O Hsp90 protein htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1036532_1 614083.AWQR01000055_gene1960 5.37e-57 190.0 28HAQ@1|root,2Z7N0@2|Bacteria,1N5R2@1224|Proteobacteria,2VKW4@28216|Betaproteobacteria,4AGAD@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - DUF2157 k59_822228_1 1000565.METUNv1_01923 1.51e-115 338.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,2KUA5@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_679292_1 1000565.METUNv1_03649 2.13e-81 244.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,2KWPK@206389|Rhodocyclales 206389|Rhodocyclales K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_45167_2 296591.Bpro_1394 1.45e-68 221.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,4A9YV@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family urtB - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_80537_1 1000565.METUNv1_00061 2.27e-117 355.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VHHU@28216|Betaproteobacteria,2KVK7@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_1113780_2 700598.Niako_4425 9.95e-11 60.5 COG1595@1|root,COG1595@2|Bacteria,4NM40@976|Bacteroidetes,1IRKZ@117747|Sphingobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - - - - - - - - - - Sigma70_r2 k59_473298_1 1198452.Jab_1c12840 5.31e-06 47.8 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4728E@75682|Oxalobacteraceae 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_8709_2 1000565.METUNv1_00681 9.31e-59 188.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,2KVFV@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_442841_1 1000565.METUNv1_00566 7.58e-104 318.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,2KUV2@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_657148_1 1000565.METUNv1_00676 2.16e-90 275.0 COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,2VN7N@28216|Betaproteobacteria,2KUR6@206389|Rhodocyclales 206389|Rhodocyclales T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg k59_151165_1 857087.Metme_0166 4.06e-43 155.0 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,1RQ8C@1236|Gammaproteobacteria,1XDKK@135618|Methylococcales 135618|Methylococcales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_151165_2 686340.Metal_3891 3.6e-160 472.0 COG1538@1|root,COG1538@2|Bacteria,1P0S2@1224|Proteobacteria,1SYX4@1236|Gammaproteobacteria,1XE3N@135618|Methylococcales 135618|Methylococcales MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_45181_1 1000565.METUNv1_02076 1.86e-27 114.0 COG2199@1|root,COG3920@1|root,COG2199@2|Bacteria,COG3920@2|Bacteria,1RGCV@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GAPES3,GGDEF,HATPase_c,MHYT,Reg_prop,SBP_bac_3,Y_Y_Y k59_45181_2 1236959.BAMT01000019_gene710 2.96e-52 168.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,2VU5Y@28216|Betaproteobacteria,2KMXB@206350|Nitrosomonadales 206350|Nitrosomonadales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_45181_3 1000565.METUNv1_02078 1.89e-96 283.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,2VQ18@28216|Betaproteobacteria,2KW3V@206389|Rhodocyclales 206389|Rhodocyclales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_45181_4 1000565.METUNv1_02079 1.31e-76 248.0 COG1273@1|root,COG1273@2|Bacteria,1QVC4@1224|Proteobacteria,2WGPK@28216|Betaproteobacteria,2KWNJ@206389|Rhodocyclales 206389|Rhodocyclales S zinc-ribbon domain - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_864853_1 1000565.METUNv1_02641 1.67e-73 222.0 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,2VUJ4@28216|Betaproteobacteria,2KWX8@206389|Rhodocyclales 206389|Rhodocyclales N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_864853_2 1000565.METUNv1_02642 6.37e-78 233.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2VSK1@28216|Betaproteobacteria,2KWN2@206389|Rhodocyclales 206389|Rhodocyclales N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_864853_3 1000565.METUNv1_02643 2.48e-27 105.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2VSF6@28216|Betaproteobacteria,2KWMP@206389|Rhodocyclales 206389|Rhodocyclales N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_722428_1 1121033.AUCF01000004_gene4875 5.74e-67 208.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria,2JTHR@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_220503_1 4565.EPlTAEP00000010100 4.44e-153 450.0 COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,3KM7Q@4447|Liliopsida,3IE0D@38820|Poales 35493|Streptophyta C Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone - - 1.6.5.3 ko:K03883 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - NADH5_C,Proton_antipo_M,Proton_antipo_N k59_45194_2 1304883.KI912532_gene2272 2.57e-28 106.0 COG0243@1|root,COG0243@2|Bacteria,1MWPS@1224|Proteobacteria,2VHYH@28216|Betaproteobacteria,2KYCY@206389|Rhodocyclales 206389|Rhodocyclales C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin k59_335196_1 1123392.AQWL01000009_gene1050 2.28e-44 153.0 COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VPIW@28216|Betaproteobacteria,1KSZ2@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyl transferase WecB/TagA/CpsF family - - - - - - - - - - - - Glyco_tran_WecB k59_657194_1 545695.TREAZ_1458 1.62e-22 95.9 COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes 203691|Spirochaetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1113823_1 279714.FuraDRAFT_1008 1.09e-20 90.5 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VPW8@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase subunit III norE - 1.9.3.1 ko:K02164,ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081,R00294 RC00016,RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10,3.D.4.4,3.D.4.6 - - COX3 k59_722439_1 1000565.METUNv1_00352 2.94e-192 540.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,2KVPI@206389|Rhodocyclales 206389|Rhodocyclales S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_335219_1 1216967.L100_11714 6.64e-64 202.0 2DB8X@1|root,2Z7T1@2|Bacteria,4NJ4R@976|Bacteroidetes,1I1UR@117743|Flavobacteriia 976|Bacteroidetes S PFAM Suppressor of fused protein (SUFU) - - - - - - - - - - - - SUFU k59_513916_2 1196835.A458_20165 7.2e-59 197.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,1RYEY@1236|Gammaproteobacteria,1Z2HH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family intF GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896 - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_473363_1 1502770.JQMG01000001_gene2372 1.29e-59 197.0 COG0778@1|root,COG0778@2|Bacteria,1RDTR@1224|Proteobacteria,2W846@28216|Betaproteobacteria,2KNVX@206350|Nitrosomonadales 206350|Nitrosomonadales C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1085591_1 614083.AWQR01000044_gene2008 1.32e-18 83.6 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,4AAIN@80864|Comamonadaceae 28216|Betaproteobacteria M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_296185_1 561230.PC1_2873 1.83e-27 107.0 2DQPP@1|root,337Z2@2|Bacteria,1N81K@1224|Proteobacteria,1SFR0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_296185_2 1129374.AJE_10458 2.73e-22 96.3 COG4637@1|root,COG4938@1|root,COG4637@2|Bacteria,COG4938@2|Bacteria,1NEEG@1224|Proteobacteria,1RZMD@1236|Gammaproteobacteria,468W7@72275|Alteromonadaceae 1236|Gammaproteobacteria S AAA ATPase domain - - - - - - - - - - - - AAA_15,DUF3696 k59_1113837_1 316067.Geob_3226 7.58e-08 55.1 COG0784@1|root,COG0834@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg k59_1113837_2 1124983.PFLCHA0_c33500 1.1e-32 123.0 COG0329@1|root,COG0329@2|Bacteria,1R45B@1224|Proteobacteria,1RS1N@1236|Gammaproteobacteria,1YNME@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_685831_1 1005048.CFU_0729 5.27e-67 211.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,4725E@75682|Oxalobacteraceae 28216|Betaproteobacteria P Rhodanese Homology Domain sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_685831_2 1144319.PMI16_01443 1.1e-51 170.0 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,4724R@75682|Oxalobacteraceae 28216|Betaproteobacteria P Divalent heavy-metal cations transporter - - - ko:K16267 - - - - ko00000,ko02000 2.A.5.4.11 - - Zip k59_192629_1 1242864.D187_008636 8.46e-39 149.0 COG4191@1|root,COG4191@2|Bacteria,1NQWQ@1224|Proteobacteria,42TV1@68525|delta/epsilon subdivisions,2WVT9@28221|Deltaproteobacteria 2|Bacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HDOD,PAS_4 k59_80604_1 631362.Thi970DRAFT_04011 3.26e-69 235.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1WWR1@135613|Chromatiales 135613|Chromatiales KL DNA RNA helicase - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_1009287_1 1127518.H9C102_9CAUD 4.57e-37 143.0 4QJD7@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_902632_1 1120956.JHZK01000005_gene2281 8.26e-10 60.1 COG3698@1|root,COG3698@2|Bacteria,1NH9S@1224|Proteobacteria,2TT5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S periplasmic protein - - - - - - - - - - - - NAGPA k59_902632_2 1238182.C882_3275 3.88e-13 70.5 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,2JZR9@204441|Rhodospirillales 204441|Rhodospirillales P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - ko:K07232 - - - - ko00000 - - - ChaC k59_657260_1 1122605.KB893648_gene3664 7.31e-43 156.0 COG0706@1|root,COG0706@2|Bacteria,4NESJ@976|Bacteroidetes,1IQAZ@117747|Sphingobacteriia 976|Bacteroidetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_151252_1 927677.ALVU02000001_gene2675 5.71e-55 195.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria 1117|Cyanobacteria Q Amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_723613_1 1000565.METUNv1_00084 3.27e-106 319.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KV3K@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains ntrC - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_337111_1 365044.Pnap_2140 1.35e-80 253.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2VI2F@28216|Betaproteobacteria,4A9WG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD k59_116628_1 883126.HMPREF9710_03468 2.56e-20 92.0 COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,473TS@75682|Oxalobacteraceae 28216|Betaproteobacteria S transport system, periplasmic component - - - - - - - - - - - - NMT1_3 k59_337133_1 398578.Daci_1337 6.79e-34 128.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,4AB4R@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_337133_2 614083.AWQR01000001_gene3100 3.48e-29 108.0 COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2VS9I@28216|Betaproteobacteria,4AED0@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_723639_2 305700.B447_05123 2.16e-62 192.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,2KWP9@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_903576_1 76114.ebA5328 2.93e-42 154.0 COG1032@1|root,COG1032@2|Bacteria,1PK5W@1224|Proteobacteria,2VJIN@28216|Betaproteobacteria,2KVTD@206389|Rhodocyclales 206389|Rhodocyclales C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM k59_796483_1 272134.KB731324_gene3254 5.05e-13 71.6 COG3222@1|root,COG3222@2|Bacteria,1G536@1117|Cyanobacteria,1HAJD@1150|Oscillatoriales 1117|Cyanobacteria S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_1045045_1 338969.Rfer_0273 1.18e-102 315.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria,4ACZX@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fcs - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding k59_194621_1 1276756.AUEX01000013_gene1471 3.56e-143 426.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4AA18@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_260860_2 266265.Bxe_A3055 3.84e-08 55.5 29F88@1|root,3025X@2|Bacteria,1NBJS@1224|Proteobacteria,2VWHK@28216|Betaproteobacteria,1KB80@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_152625_1 1198452.Jab_1c20820 4.89e-59 199.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria,478GF@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_758079_1 243365.CV_0612 4.49e-52 177.0 COG2984@1|root,COG2984@2|Bacteria,1PEQ1@1224|Proteobacteria,2W4ER@28216|Betaproteobacteria 28216|Betaproteobacteria S ABC transporter substrate binding protein - - - - - - - - - - - - - k59_337168_1 670292.JH26_02520 7.71e-39 135.0 COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,2U6ZZ@28211|Alphaproteobacteria,1JUYI@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_686907_1 666685.R2APBS1_1751 3.6e-26 109.0 COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,1S0F7@1236|Gammaproteobacteria,1X8DY@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_579424_1 1000565.METUNv1_01414 6.98e-159 448.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,2KV99@206389|Rhodocyclales 206389|Rhodocyclales U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_579424_2 1000565.METUNv1_01415 1.49e-77 233.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,2KWZE@206389|Rhodocyclales 206389|Rhodocyclales U Biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_758084_1 1000565.METUNv1_01001 9.09e-97 285.0 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2VKKB@28216|Betaproteobacteria,2KX5M@206389|Rhodocyclales 206389|Rhodocyclales O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C,GST_N_3 k59_686909_1 543728.Vapar_0461 7.41e-106 321.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,4AACX@80864|Comamonadaceae 28216|Betaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_544473_1 748247.AZKH_2091 2.31e-78 247.0 COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,2VKWI@28216|Betaproteobacteria,2KV4U@206389|Rhodocyclales 206389|Rhodocyclales T Cache 3/Cache 2 fusion domain - - 2.7.13.3 ko:K02480 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,sCache_2 k59_445051_1 1198452.Jab_1c07570 4.47e-63 215.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,473FB@75682|Oxalobacteraceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_445051_2 883126.HMPREF9710_00395 2.16e-06 50.1 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,472PH@75682|Oxalobacteraceae 28216|Betaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion mdtA1 - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_297469_2 762376.AXYL_04624 1.99e-12 65.5 2FBPB@1|root,343UB@2|Bacteria,1P394@1224|Proteobacteria,2W41R@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_515976_1 1122951.ATUE01000005_gene1552 6.53e-52 176.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RPKP@1236|Gammaproteobacteria,3NKH4@468|Moraxellaceae 1236|Gammaproteobacteria S CobW/HypB/UreG, nucleotide-binding domain yeiR GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - - - - - - - - - - CobW_C,cobW k59_1114922_1 1504672.669785709 8.73e-32 131.0 COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,2WGSC@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_686912_1 1000565.METUNv1_01108 4.69e-34 127.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria,2KV6E@206389|Rhodocyclales 206389|Rhodocyclales E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1,4.4.1.8 ko:K01758,ko:K01760 ko00260,ko00270,ko00450,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R01001,R01286,R02408,R04770,R04930,R04941,R09366 RC00056,RC00069,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_686912_2 1007105.PT7_2514 3.2e-51 166.0 COG3290@1|root,COG3290@2|Bacteria,1QWJA@1224|Proteobacteria 1224|Proteobacteria T PAS fold - - - - - - - - - - - - PAS,PAS_4 k59_686912_3 1000565.METUNv1_00343 2.33e-30 120.0 COG1538@1|root,COG1538@2|Bacteria,1R744@1224|Proteobacteria,2VJW4@28216|Betaproteobacteria,2KYCU@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_866256_1 29581.BW37_05505 1.4e-06 48.9 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,472NJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_866256_2 1005048.CFU_3255 7.58e-57 183.0 COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2WENS@28216|Betaproteobacteria,4749G@75682|Oxalobacteraceae 28216|Betaproteobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_659410_1 1237149.C900_04022 1.25e-78 247.0 COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes,47MHR@768503|Cytophagia 976|Bacteroidetes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1114931_1 929562.Emtol_1186 2.23e-75 249.0 COG3002@1|root,COG3002@2|Bacteria,4NECE@976|Bacteroidetes,47MDY@768503|Cytophagia 976|Bacteroidetes S Belongs to the UPF0753 family - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_194675_1 1000565.METUNv1_03040 6.46e-73 221.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VQR5@28216|Betaproteobacteria,2KWQV@206389|Rhodocyclales 206389|Rhodocyclales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1087512_1 1121861.KB899943_gene3903 3.76e-22 91.3 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2JS6P@204441|Rhodospirillales 204441|Rhodospirillales O Redoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_832134_1 744872.Spica_0738 2.63e-56 185.0 COG0395@1|root,COG0395@2|Bacteria,2J9P9@203691|Spirochaetes 203691|Spirochaetes P Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k59_936657_1 1177154.Y5S_03777 8.74e-137 389.0 2DUNM@1|root,33REW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_445091_1 596154.Alide2_4184 2.52e-97 290.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,4ABGR@80864|Comamonadaceae 28216|Betaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_337233_1 234831.PSM_B0479 6.28e-101 297.0 2F10E@1|root,33U1X@2|Bacteria,1RHYK@1224|Proteobacteria,1SNRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_474620_1 1123401.JHYQ01000035_gene3491 5.68e-08 58.5 COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,1RQ66@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_732955_1 864051.BurJ1DRAFT_1750 1.73e-70 238.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,2W0AD@28216|Betaproteobacteria,1KMY4@119065|unclassified Burkholderiales 28216|Betaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - - k59_56093_1 748280.NH8B_0950 6e-75 231.0 2BYE4@1|root,32R37@2|Bacteria,1MYFN@1224|Proteobacteria,2VTEJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - DUF1566 k59_732967_1 1000565.METUNv1_01326 4.14e-89 266.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,2KVBA@206389|Rhodocyclales 206389|Rhodocyclales O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_732967_2 1000565.METUNv1_01325 1.02e-29 112.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,2KV37@206389|Rhodocyclales 206389|Rhodocyclales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_911874_1 748247.AZKH_1245 0.000145 49.3 COG0840@1|root,COG2703@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUJI@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_2,sCache_2 k59_379002_1 296591.Bpro_0300 1.49e-119 362.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,4ABCX@80864|Comamonadaceae 28216|Betaproteobacteria V TIGRFAM type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_460348_1 1304885.AUEY01000056_gene1438 1.7e-30 118.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2MJCW@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM N-6 DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_460348_2 1219072.VHA01S_019_00650 3.84e-56 187.0 COG0732@1|root,COG0732@2|Bacteria,1MXSQ@1224|Proteobacteria,1S320@1236|Gammaproteobacteria,1XXDQ@135623|Vibrionales 135623|Vibrionales V COG0732 Restriction endonuclease S subunits - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_911888_1 1000565.METUNv1_00354 3.03e-136 396.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,2KUCB@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_1123786_1 365044.Pnap_2576 1.61e-27 109.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,4A9RZ@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1123786_2 338969.Rfer_2777 7.01e-33 118.0 2E6EI@1|root,33120@2|Bacteria,1NA6C@1224|Proteobacteria,2VW1M@28216|Betaproteobacteria,4AEZA@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_766341_1 1198452.Jab_1c11670 1.28e-26 107.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,47297@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA topoisomerase topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_766341_2 1198452.Jab_1c11660 8.85e-48 155.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,4745B@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_19782_1 321955.AAGP01000013_gene719 1.44e-17 86.7 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4F8VZ@85019|Brevibacteriaceae 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_56135_2 365046.Rta_18960 8.36e-60 192.0 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,4ADK6@80864|Comamonadaceae 28216|Betaproteobacteria S Tetratricopeptide repeat-like domain - - - - - - - - - - - - TPR_21 k59_1059282_1 76114.ebA1330 2.58e-91 290.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KUWE@206389|Rhodocyclales 206389|Rhodocyclales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_126648_1 1121035.AUCH01000005_gene197 7.32e-67 210.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2VIKF@28216|Betaproteobacteria,2KVVZ@206389|Rhodocyclales 206389|Rhodocyclales D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_911919_2 1178482.BJB45_17765 3.9e-22 92.4 COG0500@1|root,COG2226@2|Bacteria,1MXYF@1224|Proteobacteria,1RNWC@1236|Gammaproteobacteria,1XNVM@135619|Oceanospirillales 135619|Oceanospirillales Q Methyltransferase domain - - - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_587400_1 1217656.F964_01064 2.3e-87 264.0 COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,1RNZ8@1236|Gammaproteobacteria,3NKY1@468|Moraxellaceae 1236|Gammaproteobacteria C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_766361_1 596154.Alide2_0044 4.36e-90 291.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,4A9VI@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_309114_1 595537.Varpa_2212 2.26e-90 293.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,4ACU7@80864|Comamonadaceae 28216|Betaproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_271416_1 1163409.UUA_15558 7.1e-12 66.6 2EJH9@1|root,33D87@2|Bacteria,1NHKW@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_587416_1 1270193.JARP01000001_gene2246 5.86e-81 263.0 COG0474@1|root,COG0474@2|Bacteria,4NERM@976|Bacteroidetes,1HY67@117743|Flavobacteriia,2NT0H@237|Flavobacterium 976|Bacteroidetes P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_696501_1 497321.C664_05231 1.8e-21 87.4 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria,2KWTZ@206389|Rhodocyclales 206389|Rhodocyclales J chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_696501_2 765911.Thivi_0047 1.41e-122 358.0 COG2843@1|root,COG2843@2|Bacteria,1PGVS@1224|Proteobacteria,1RXHX@1236|Gammaproteobacteria,1X1CU@135613|Chromatiales 135613|Chromatiales M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_379112_2 1000565.METUNv1_02085 6.49e-114 330.0 COG2413@1|root,COG2413@2|Bacteria,1RFTH@1224|Proteobacteria,2VJC9@28216|Betaproteobacteria,2KUIR@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1123839_2 981335.G4W952_9CAUD 5.34e-133 405.0 4QFZI@10239|Viruses,4QX8G@35237|dsDNA viruses no RNA stage,4QPD8@28883|Caudovirales 28883|Caudovirales S Terminase-like family - - - - - - - - - - - - - k59_911960_1 1177179.A11A3_02022 2.84e-45 166.0 COG0726@1|root,COG3868@1|root,COG0726@2|Bacteria,COG3868@2|Bacteria,1MXYK@1224|Proteobacteria,1RMK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Glycoside-hydrolase family GH114 pelA - - ko:K21006 ko02025,map02025 - - - ko00000,ko00001 - - - Glyco_hydro_114 k59_271446_1 596151.DesfrDRAFT_2402 1.36e-59 196.0 COG0037@1|root,COG0037@2|Bacteria,1R4D0@1224|Proteobacteria,42QGB@68525|delta/epsilon subdivisions,2X69D@28221|Deltaproteobacteria,2MGZX@213115|Desulfovibrionales 28221|Deltaproteobacteria H TIGRFAM N-acetyl sugar amidotransferase - - - - - - - - - - - - - k59_696515_1 296591.Bpro_1148 5.27e-85 264.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,4AD65@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily fbpC - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1019928_2 990285.RGCCGE502_13964 1.17e-80 248.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,4B99V@82115|Rhizobiaceae 28211|Alphaproteobacteria C Aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_485453_1 1177154.Y5S_00995 8.46e-84 263.0 COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,1RR6Y@1236|Gammaproteobacteria,1XJCM@135619|Oceanospirillales 135619|Oceanospirillales C cytochrome P450 - - - - - - - - - - - - p450 k59_460496_1 225937.HP15_1191 7.13e-30 111.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,464SC@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_841974_1 1502852.FG94_03180 5.31e-56 184.0 COG4758@1|root,COG4758@2|Bacteria,1RFX6@1224|Proteobacteria,2WCSU@28216|Betaproteobacteria,4772Z@75682|Oxalobacteraceae 28216|Betaproteobacteria S membrane - - - - - - - - - - - - - k59_379158_1 76114.ebA1102 3.19e-91 276.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,2KUIY@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_162793_1 887062.HGR_00275 6.96e-22 89.7 COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2VRPF@28216|Betaproteobacteria,4AJCE@80864|Comamonadaceae 28216|Betaproteobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_162793_2 338969.Rfer_3388 8.31e-43 144.0 COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,2WFNG@28216|Betaproteobacteria,4AE66@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM OsmC family protein - - - - - - - - - - - - OsmC k59_1059384_1 358220.C380_17665 2.91e-46 160.0 COG2324@1|root,COG2324@2|Bacteria,1RA24@1224|Proteobacteria 1224|Proteobacteria S Carotenoid biosynthesis protein - - - - - - - - - - - - Caroten_synth k59_621212_1 338969.Rfer_1986 1.15e-90 272.0 COG1639@1|root,COG1639@2|Bacteria,1NQD3@1224|Proteobacteria,2VPTF@28216|Betaproteobacteria,4ABWF@80864|Comamonadaceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_696539_2 1000565.METUNv1_02400 7.34e-101 293.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,2KWBU@206389|Rhodocyclales 206389|Rhodocyclales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_532110_1 1123508.JH636439_gene1078 9.27e-16 82.0 COG2165@1|root,COG2165@2|Bacteria,2IYXI@203682|Planctomycetes 203682|Planctomycetes NU Protein of unknown function (DUF1559) - - - - - - - - - - - - N_methyl,SBP_bac_10 k59_555504_1 1000565.METUNv1_03037 1.87e-42 162.0 COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,2VN4Y@28216|Betaproteobacteria,2KYER@206389|Rhodocyclales 206389|Rhodocyclales L AAA domain - - - - - - - - - - - - AAA_23 k59_696557_1 1122951.ATUE01000005_gene2217 1.66e-134 399.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,3NIUT@468|Moraxellaceae 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_675295_1 614083.AWQR01000019_gene3786 8.57e-34 119.0 COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,4AEG5@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_675295_2 614083.AWQR01000019_gene3787 3.31e-59 188.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,4AAWM@80864|Comamonadaceae 28216|Betaproteobacteria U Mota tolq exbb proton channel tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB k59_56223_1 1000565.METUNv1_01312 3.5e-82 256.0 COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,2KW2J@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - - - - - - - - - - ZipA_C k59_733114_2 614083.AWQR01000026_gene3558 6.86e-19 84.7 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_766446_1 614083.AWQR01000005_gene1170 2.07e-53 187.0 COG1231@1|root,COG1231@2|Bacteria,1NVGR@1224|Proteobacteria,2VJU0@28216|Betaproteobacteria,4AB24@80864|Comamonadaceae 28216|Betaproteobacteria E Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_842052_1 95619.PM1_0200625 9.41e-186 523.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria 1236|Gammaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_532181_1 1198452.Jab_2c33250 6.33e-16 78.2 COG5126@1|root,COG5126@2|Bacteria,1NC1I@1224|Proteobacteria,2VW5S@28216|Betaproteobacteria 28216|Betaproteobacteria DTZ EF-hand, calcium binding motif - - - - - - - - - - - - EF-hand_5,EF-hand_7 k59_485544_1 1000565.METUNv1_01056 4.89e-70 226.0 COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,2VKWI@28216|Betaproteobacteria,2KV4U@206389|Rhodocyclales 206389|Rhodocyclales T Cache 3/Cache 2 fusion domain - - 2.7.13.3 ko:K02480 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,sCache_2 k59_19923_1 595537.Varpa_5988 6.55e-29 104.0 2EGTE@1|root,33AJI@2|Bacteria,1N5DW@1224|Proteobacteria,2VUCZ@28216|Betaproteobacteria,4AF85@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of Unknown Function (DUF350) - - - - - - - - - - - - DUF350 k59_19923_2 358220.C380_23610 6.16e-37 139.0 COG1379@1|root,COG1379@2|Bacteria,1MVED@1224|Proteobacteria,2VJM0@28216|Betaproteobacteria,4AAC2@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4178) - - - - - - - - - - - - DUF4178 k59_555558_1 1380387.JADM01000006_gene1237 2.64e-39 137.0 COG1309@1|root,COG1309@2|Bacteria,1RGJ3@1224|Proteobacteria,1S5R9@1236|Gammaproteobacteria,1XS74@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1020036_1 1333856.L686_17300 6.52e-16 82.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,1Z1CM@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria N Flagellar hook protein FlgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_944695_2 1121033.AUCF01000004_gene4997 1.47e-12 66.6 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,2JQSW@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K12368 ko02010,ko02030,map02010,map02030 M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_56261_2 522306.CAP2UW1_2592 1.03e-29 114.0 COG2207@1|root,COG2207@2|Bacteria,1N8IV@1224|Proteobacteria,2WF2K@28216|Betaproteobacteria 28216|Betaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_696595_1 1000565.METUNv1_03461 2.32e-92 283.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KVWV@206389|Rhodocyclales 206389|Rhodocyclales S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_696595_2 1000565.METUNv1_03462 1.61e-12 66.6 COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,2KXG7@206389|Rhodocyclales 206389|Rhodocyclales S Alkaline phosphatase - - - - - - - - - - - - - k59_944700_1 365044.Pnap_2945 2.64e-91 275.0 COG0703@1|root,COG0703@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,4ABJG@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK_2 - - ko:K15546 - - - - ko00000,ko03000 - - - HTH_3,HTH_31,SKI k59_532220_1 62928.azo1613 8.17e-118 365.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales 206389|Rhodocyclales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_555577_1 936053.I1CFZ0 5.24e-42 161.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi 4751|Fungi Z retrotransposable element tf2 155 kda protein type 1-like - - - - - - - - - - - - Asp_protease_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve,zf-CCHC k59_91399_1 1094466.KQS_05795 3.09e-32 128.0 COG0535@1|root,COG0535@2|Bacteria,4NEGK@976|Bacteroidetes,1HYIP@117743|Flavobacteriia,2NSD2@237|Flavobacterium 976|Bacteroidetes S radical SAM domain protein - - - - - - - - - - - - - k59_555599_1 232721.Ajs_3878 2.14e-183 527.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,4ABF6@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Phospholipid glycerol acyltransferase aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase,MFS_1 k59_411565_1 1000565.METUNv1_03393 0.000695 41.6 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,2KV8T@206389|Rhodocyclales 206389|Rhodocyclales U MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_411565_2 1000565.METUNv1_03392 1.94e-73 223.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,2KWWA@206389|Rhodocyclales 206389|Rhodocyclales S Tol-pal system-associated acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_555605_1 1198452.Jab_2c28650 3.6e-64 220.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,473JA@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_808225_2 1250006.JHZZ01000001_gene1563 1.83e-19 83.2 2CENM@1|root,32S06@2|Bacteria,4NVR4@976|Bacteroidetes,1I5EG@117743|Flavobacteriia,3VWT1@52959|Polaribacter 976|Bacteroidetes - - - - - - - - - - - - - - - k59_463015_2 93220.LV28_00425 4.39e-11 65.1 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,1K0NX@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_945986_2 1000565.METUNv1_00277 3.03e-57 186.0 COG0745@1|root,COG0745@2|Bacteria,1R7VB@1224|Proteobacteria,2VI0D@28216|Betaproteobacteria,2KVAH@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2,Response_reg k59_677911_1 29581.BW37_00450 2.46e-18 85.1 COG1192@1|root,COG1192@2|Bacteria 2|Bacteria D plasmid maintenance - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,MipZ k59_285713_4 987059.RBXJA2T_04503 2.16e-34 132.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1070986_2 1000565.METUNv1_01313 1.13e-93 301.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales 206389|Rhodocyclales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_250020_1 1056820.KB900652_gene3372 1.91e-77 257.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,2PPBG@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L DNA polymerase alpha chain like domain dnaE2 GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_999525_1 929713.NIASO_20055 7.47e-147 426.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1IRQA@117747|Sphingobacteriia 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - - k59_392788_1 596154.Alide2_0986 5.07e-93 286.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,4AAEI@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM peptidase M16 domain protein - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_214_1 640081.Dsui_3364 1.83e-84 273.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,2KVJ1@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_285719_2 640081.Dsui_2721 1.16e-54 175.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,2KWPI@206389|Rhodocyclales 206389|Rhodocyclales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1071002_1 981336.F944_03075 5.09e-39 137.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,3NJVA@468|Moraxellaceae 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt k59_1071002_2 1336245.JAGO01000013_gene1580 1.28e-13 71.6 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XHRG@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_178714_1 522306.CAP2UW1_4442 5.33e-45 148.0 COG4113@1|root,COG4113@2|Bacteria,1RIR6@1224|Proteobacteria,2VSUI@28216|Betaproteobacteria 28216|Betaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_178714_2 1122603.ATVI01000005_gene3871 2.49e-20 83.6 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_499939_1 398767.Glov_2003 1.08e-46 172.0 COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X6YR@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_142954_1 1000565.METUNv1_00677 1.2e-183 525.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales 206389|Rhodocyclales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_214309_1 1000565.METUNv1_03387 2.72e-200 566.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUDD@206389|Rhodocyclales 206389|Rhodocyclales S of ABC transporters with duplicated ATPase ybiT - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_214309_2 1000565.METUNv1_03388 1.02e-38 139.0 COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,2VHD9@28216|Betaproteobacteria,2KUNH@206389|Rhodocyclales 206389|Rhodocyclales U glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_963831_1 1173263.Syn7502_01820 3.22e-38 146.0 COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria,1GMRW@1117|Cyanobacteria,1GZJS@1129|Synechococcus 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_321501_1 1000565.METUNv1_03175 2.65e-42 140.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,2KWWQ@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_321501_2 1000565.METUNv1_03176 1.12e-110 332.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_250048_1 614083.AWQR01000010_gene1568 7.55e-112 330.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,4AAYY@80864|Comamonadaceae 28216|Betaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_107232_1 640081.Dsui_1866 3.88e-21 87.4 COG2199@1|root,COG3706@2|Bacteria,1QXNF@1224|Proteobacteria,2WHUX@28216|Betaproteobacteria,2KZXI@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_107232_2 1265503.KB905163_gene2234 1.73e-17 83.6 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1RWN0@1236|Gammaproteobacteria,2Q810@267889|Colwelliaceae 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS,Response_reg k59_178736_1 1198452.Jab_2c33490 7.81e-52 172.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,472UD@75682|Oxalobacteraceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_535538_1 1123073.KB899242_gene1304 1.15e-74 239.0 COG0654@1|root,COG0654@2|Bacteria,1NSGN@1224|Proteobacteria,1T22A@1236|Gammaproteobacteria,1XA19@135614|Xanthomonadales 135614|Xanthomonadales CH Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_1071041_1 765869.BDW_03445 1.99e-48 176.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_999551_1 1000565.METUNv1_02920 2.98e-138 397.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2VHZZ@28216|Betaproteobacteria,2KUW8@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_999551_2 1000565.METUNv1_02921 3.18e-101 301.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,2KWAY@206389|Rhodocyclales 206389|Rhodocyclales S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_464221_2 864051.BurJ1DRAFT_3301 1.22e-36 130.0 COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,2VQJ7@28216|Betaproteobacteria,1KKJD@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_714067_1 1000565.METUNv1_00866 2.09e-129 376.0 COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,2VH2D@28216|Betaproteobacteria,2KVGU@206389|Rhodocyclales 28216|Betaproteobacteria E glycosyl transferase family trpD3 - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_142971_1 1095769.CAHF01000025_gene648 5.22e-75 230.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,472G3@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N k59_142971_2 1129794.C427_2891 1.22e-113 345.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4645Y@72275|Alteromonadaceae 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CZB,DUF4118,EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_9,Protoglobin k59_856770_1 1000565.METUNv1_03671 1.25e-123 393.0 COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis yapH - - ko:K13735,ko:K19231 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.12 - - Autotransporter,ESPR,Haemagg_act,PATR k59_107242_2 1000565.METUNv1_02005 2.2e-68 214.0 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2VHM4@28216|Betaproteobacteria,2KUB4@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ k59_606873_1 1150600.ADIARSV_3063 9.92e-16 83.2 COG3291@1|root,COG3291@2|Bacteria,4NJ47@976|Bacteroidetes,1IPFX@117747|Sphingobacteriia 976|Bacteroidetes N C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,PKD k59_214330_1 1000565.METUNv1_02416 3.46e-231 647.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VNYV@28216|Betaproteobacteria,2KV5E@206389|Rhodocyclales 206389|Rhodocyclales T Bacterial regulatory protein, Fis family - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_250894_2 1000565.METUNv1_01820 2.21e-70 220.0 COG3568@1|root,COG3568@2|Bacteria,1R8DZ@1224|Proteobacteria,2WGET@28216|Betaproteobacteria,2M04Q@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_107948_1 640081.Dsui_0919 9.3e-48 164.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KUMQ@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_857374_1 1163617.SCD_n00906 2.41e-57 200.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2W14J@28216|Betaproteobacteria 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_1072235_2 1000565.METUNv1_01435 9.36e-07 49.7 2BTZF@1|root,32P80@2|Bacteria,1N8SX@1224|Proteobacteria,2VW68@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_750405_1 1000565.METUNv1_03995 1.41e-127 375.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,2KUU8@206389|Rhodocyclales 206389|Rhodocyclales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_322648_1 1000565.METUNv1_02942 8.05e-53 177.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales 206389|Rhodocyclales J Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_322648_2 1000565.METUNv1_02941 1.8e-88 261.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VQR5@28216|Betaproteobacteria,2M00A@206389|Rhodocyclales 206389|Rhodocyclales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_643925_1 1000565.METUNv1_01397 2.67e-122 351.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,2KUU9@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_322655_1 1366050.N234_22015 9.91e-42 155.0 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K16H@119060|Burkholderiaceae 28216|Betaproteobacteria NT histidine kinase HAMP region domain protein cheD2 - - ko:K03406,ko:K03776,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,TarH k59_179858_1 1000565.METUNv1_02684 1.42e-30 116.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KW8Q@206389|Rhodocyclales 206389|Rhodocyclales S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_179858_2 1000565.METUNv1_02683 6.59e-182 528.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales 206389|Rhodocyclales E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_393778_1 266265.Bxe_B2869 1.22e-80 253.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VIZQ@28216|Betaproteobacteria,1K0GN@119060|Burkholderiaceae 28216|Betaproteobacteria S CBS domain containing protein corC1 - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_393778_2 1101195.Meth11DRAFT_0514 7.1e-28 113.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KMH3@206350|Nitrosomonadales 206350|Nitrosomonadales T GAF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS k59_501157_1 1123392.AQWL01000009_gene1041 0.000302 42.4 2AG0P@1|root,3164R@2|Bacteria,1PWV4@1224|Proteobacteria,2WCDT@28216|Betaproteobacteria,1KTH7@119069|Hydrogenophilales 119069|Hydrogenophilales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_501157_2 1000565.METUNv1_00707 3.11e-110 320.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VHTZ@28216|Betaproteobacteria,2KVHA@206389|Rhodocyclales 206389|Rhodocyclales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_607413_1 1000565.METUNv1_02401 6.55e-175 494.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,2KUY4@206389|Rhodocyclales 206389|Rhodocyclales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_607413_2 1000565.METUNv1_02402 5.64e-41 148.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KVHE@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_143772_1 1090319.KE386571_gene1883 0.000215 49.3 COG1572@1|root,COG1572@2|Bacteria,1QUT4@1224|Proteobacteria,2TW6F@28211|Alphaproteobacteria,2KEC1@204457|Sphingomonadales 204457|Sphingomonadales NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - VPEP k59_643937_1 338969.Rfer_2975 1.35e-70 224.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,4AAT8@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_358115_1 502025.Hoch_4860 1.68e-89 275.0 COG0688@1|root,COG0688@2|Bacteria,1PCNR@1224|Proteobacteria,42NZ3@68525|delta/epsilon subdivisions,2WZZS@28221|Deltaproteobacteria,2Z0HE@29|Myxococcales 28221|Deltaproteobacteria I Belongs to the phosphatidylserine decarboxylase family - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PSDC,PS_Dcarbxylase k59_571845_1 1000565.METUNv1_02301 3.27e-61 204.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,2KV1E@206389|Rhodocyclales 206389|Rhodocyclales O COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_358118_1 1157708.KB907454_gene3134 5.72e-83 251.0 COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,2VP6N@28216|Betaproteobacteria,4AEAT@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM Helix-turn-helix, type 11 domain protein - - - - - - - - - - - - HTH_11,WYL k59_36770_1 207954.MED92_13383 3.47e-11 66.2 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RPKP@1236|Gammaproteobacteria,1XIRM@135619|Oceanospirillales 135619|Oceanospirillales S Cobalamin synthesis protein - - - - - - - - - - - - CobW_C,cobW k59_36770_2 519989.ECTPHS_03046 1.47e-27 113.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_322680_1 1122951.ATUE01000005_gene2219 9.97e-110 328.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,3NKAA@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3206 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_643954_1 485918.Cpin_0233 5.4e-51 182.0 COG0770@1|root,COG0787@1|root,COG0770@2|Bacteria,COG0787@2|Bacteria,4NEXM@976|Bacteroidetes,1IP9R@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1,6.3.2.10 ko:K01775,ko:K01929 ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502 - R00401,R04573,R04617 RC00064,RC00141,RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_M k59_857404_1 1223521.BBJX01000004_gene2363 8.17e-26 97.8 COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,4AEWA@80864|Comamonadaceae 28216|Betaproteobacteria S Lipopolysaccharide assembly protein A domain - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_857404_2 614083.AWQR01000005_gene1140 9.67e-48 154.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,4AEE7@80864|Comamonadaceae 28216|Betaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_393793_2 85643.Tmz1t_3601 2.08e-106 340.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,2VJSS@28216|Betaproteobacteria,2KWGA@206389|Rhodocyclales 206389|Rhodocyclales L EcoEI R protein C-terminal hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF4145,EcoEI_R_C,HSDR_N,Helicase_C,ResIII k59_358121_1 1038860.AXAP01000064_gene4013 9.81e-76 241.0 COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,3JSN9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_358121_2 1268068.PG5_64430 6.05e-24 101.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_36780_1 1000565.METUNv1_03251 1.27e-106 330.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,2KUE2@206389|Rhodocyclales 206389|Rhodocyclales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_679001_1 1000565.METUNv1_01950 4.67e-70 224.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_679001_2 1000565.METUNv1_01949 2.35e-33 123.0 2DZ51@1|root,34CFR@2|Bacteria,1P4XD@1224|Proteobacteria,2W5BH@28216|Betaproteobacteria,2KZF2@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_179874_1 1000565.METUNv1_02947 1.39e-58 191.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KV7G@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_179874_3 1123367.C666_00120 8.33e-188 543.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KUFR@206389|Rhodocyclales 206389|Rhodocyclales M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_179874_4 1000565.METUNv1_02949 2.54e-22 93.6 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,2KURQ@206389|Rhodocyclales 206389|Rhodocyclales C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_821919_1 1121007.AUML01000016_gene260 9.78e-11 62.0 COG0659@1|root,COG0659@2|Bacteria,4NE9G@976|Bacteroidetes,1HYXB@117743|Flavobacteriia,2YI8N@290174|Aquimarina 976|Bacteroidetes P Sulfate permease family sulP - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Sulfate_transp k59_821919_2 1041826.FCOL_03680 3.6e-81 246.0 COG0288@1|root,COG0288@2|Bacteria,4NH0X@976|Bacteroidetes,1HXY7@117743|Flavobacteriia,2NVS1@237|Flavobacterium 976|Bacteroidetes P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_143787_1 365046.Rta_23475 2.67e-166 478.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,4A9K8@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_821920_1 76114.ebA3839 2.65e-77 233.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,2KUBB@206389|Rhodocyclales 206389|Rhodocyclales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_821920_2 1000565.METUNv1_02275 3.77e-33 115.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KWPF@206389|Rhodocyclales 206389|Rhodocyclales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_643969_2 1000565.METUNv1_03897 7.06e-52 178.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,2KV5Q@206389|Rhodocyclales 206389|Rhodocyclales M surface antigen (D15) - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA k59_358139_1 983917.RGE_43290 2.58e-108 327.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,1KIXS@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1036166_2 1000565.METUNv1_01936 4.76e-54 171.0 COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria,2KWZ7@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the frataxin cyaY - - ko:K06202 - - - - ko00000 - - - Frataxin_Cyay k59_571866_1 1379698.RBG1_1C00001G0622 5.46e-05 45.8 COG1566@1|root,COG1566@2|Bacteria 2|Bacteria V PFAM secretion protein HlyD family protein - - - ko:K01993,ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_1176_1 279714.FuraDRAFT_1787 1.16e-133 396.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2VKTE@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase with PAS PAC and GAF - - - - - - - - - - - - GAF_2,GGDEF,PAS,PAS_3,PAS_4 k59_679014_1 1000565.METUNv1_02550 3.8e-92 288.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,2KVF9@206389|Rhodocyclales 206389|Rhodocyclales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_143798_1 1538295.JY96_16320 5.56e-107 322.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1KJ18@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_179897_1 1000565.METUNv1_00505 2.81e-118 363.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales 206389|Rhodocyclales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_715100_1 1384054.N790_07980 1.75e-45 166.0 COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1NECV@1224|Proteobacteria,1S0P0@1236|Gammaproteobacteria,1XCDA@135614|Xanthomonadales 135614|Xanthomonadales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GGDEF,PAS_3 k59_865169_2 743720.Psefu_2853 1.76e-37 131.0 COG2318@1|root,COG2318@2|Bacteria,1RHRP@1224|Proteobacteria,1S2K9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DinB family - - - - - - - - - - - - DinB k59_613053_1 1005048.CFU_0561 0.000141 45.8 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,4743V@75682|Oxalobacteraceae 28216|Betaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_613053_2 204773.HEAR2914 1.66e-24 93.6 2E53D@1|root,32ZWH@2|Bacteria,1N979@1224|Proteobacteria,2VVRY@28216|Betaproteobacteria,4750N@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_151512_1 497321.C664_18432 2.75e-25 97.4 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,2KWM4@206389|Rhodocyclales 206389|Rhodocyclales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_151512_2 1397284.AYMN01000025_gene4207 4.33e-23 95.5 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,401II@613|Serratia 1236|Gammaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074 Metallophos k59_657690_1 1288494.EBAPG3_29600 3.44e-40 149.0 COG3307@1|root,COG3307@2|Bacteria,1RK09@1224|Proteobacteria,2VT4W@28216|Betaproteobacteria,373K5@32003|Nitrosomonadales 28216|Betaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_657690_2 118161.KB235919_gene6148 7.85e-70 224.0 COG1216@1|root,COG1216@2|Bacteria,1G10I@1117|Cyanobacteria,3VMVH@52604|Pleurocapsales 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_335655_1 1003200.AXXA_27990 9.03e-128 377.0 28HXV@1|root,2Z83C@2|Bacteria,1PJBP@1224|Proteobacteria,2W8RH@28216|Betaproteobacteria,3T5DR@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1086032_1 1000565.METUNv1_00756 1.71e-235 653.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,2KUKY@206389|Rhodocyclales 206389|Rhodocyclales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_865190_1 1136138.JH604625_gene3662 1.17e-126 366.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394 Aminotran_4 k59_1114058_1 1000565.METUNv1_01055 1.27e-76 233.0 COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VS1F@28216|Betaproteobacteria,2KZRB@206389|Rhodocyclales 206389|Rhodocyclales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_220769_1 1000565.METUNv1_00496 1.12e-151 453.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,2KUDV@206389|Rhodocyclales 206389|Rhodocyclales P COG0474 Cation transport ATPase - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_80817_1 266762.HQ36_04340 4.24e-32 125.0 COG1530@1|root,COG1530@2|Bacteria,4NED1@976|Bacteroidetes,2FMXV@200643|Bacteroidia,22WM6@171551|Porphyromonadaceae 976|Bacteroidetes J ribonuclease G rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_657703_1 1000565.METUNv1_02295 1e-66 217.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,2KU69@206389|Rhodocyclales 206389|Rhodocyclales C Sulfite reductase cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_865195_1 29581.BW37_05176 5.47e-78 256.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,475WI@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - CHASE,CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_7,PAS_9,Response_reg k59_402391_2 261292.Nit79A3_2571 1.78e-10 60.5 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,371SS@32003|Nitrosomonadales 28216|Betaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1009563_2 1000565.METUNv1_02767 5.95e-56 182.0 COG1639@1|root,COG1639@2|Bacteria,1R4ZN@1224|Proteobacteria,2VQ1P@28216|Betaproteobacteria,2KVUP@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_80819_1 1000565.METUNv1_01665 5.22e-176 495.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,2KV8P@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rmlB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_722710_2 1000565.METUNv1_00331 7.82e-61 194.0 COG5581@1|root,COG5581@2|Bacteria,1RFI4@1224|Proteobacteria,2VS7C@28216|Betaproteobacteria,2KWST@206389|Rhodocyclales 206389|Rhodocyclales M Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility ycgR - - - - - - - - - - - PilZ,YcgR k59_220781_1 543728.Vapar_1812 3.62e-92 271.0 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2VPZP@28216|Betaproteobacteria,4AA91@80864|Comamonadaceae 28216|Betaproteobacteria P Iron-storage protein bfr - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_578687_1 1000565.METUNv1_02336 1.49e-39 145.0 COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,2VK1M@28216|Betaproteobacteria,2KUAQ@206389|Rhodocyclales 206389|Rhodocyclales S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - VWA_CoxE k59_578687_2 1000565.METUNv1_02337 4.12e-74 230.0 COG2014@1|root,COG2014@2|Bacteria,1MV5Z@1224|Proteobacteria,2VPCD@28216|Betaproteobacteria,2KUXD@206389|Rhodocyclales 206389|Rhodocyclales S Putative heavy-metal chelation - - - - - - - - - - - - DUF364,DUF4213 k59_473673_1 869210.Marky_1283 3.53e-79 267.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1WIA7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM Conserved region in glutamate synthase - - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_657736_1 5011.R4X6L0 3.18e-05 51.2 KOG1911@1|root,KOG1911@2759|Eukaryota,3A4VP@33154|Opisthokonta,3P4Q4@4751|Fungi,3QU9J@4890|Ascomycota,3MD29@451866|Taphrinomycotina 4751|Fungi B Chromodomain protein 2 - GO:0000183,GO:0000228,GO:0000775,GO:0000785,GO:0000790,GO:0000792,GO:0003674,GO:0003682,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005720,GO:0005721,GO:0006325,GO:0006338,GO:0006342,GO:0006348,GO:0006355,GO:0006996,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0019219,GO:0019222,GO:0030466,GO:0030702,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031491,GO:0031493,GO:0031618,GO:0031934,GO:0031974,GO:0031981,GO:0040029,GO:0042393,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044877,GO:0045814,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051276,GO:0060255,GO:0065007,GO:0070013,GO:0071840,GO:0080090,GO:0098687,GO:1902679,GO:1903506,GO:1903507,GO:1990421,GO:1990707,GO:2000112,GO:2000113,GO:2001141 - ko:K11585 - - - - ko00000,ko03036 - - - Chromo,Chromo_shadow k59_151551_1 1000565.METUNv1_01872 0.0 1176.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,2KUE7@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_259914_1 1347342.BN863_20650 9.6e-20 94.4 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1HX4C@117743|Flavobacteriia 976|Bacteroidetes S PFAM ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_45534_1 536019.Mesop_0161 1.43e-41 149.0 COG0697@1|root,COG0697@2|Bacteria,1NDKG@1224|Proteobacteria,2U0DF@28211|Alphaproteobacteria,43IVC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EG EamA-like transporter family MA20_44015 - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_443470_1 1198452.Jab_2c30800 2.67e-83 259.0 COG0259@1|root,COG3945@1|root,COG0259@2|Bacteria,COG3945@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,472YJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - Hemerythrin,PNP_phzG_C,Putative_PNPOx k59_865235_1 946483.Cenrod_1121 9.74e-53 169.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,4AE26@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_865235_2 946483.Cenrod_1122 2.91e-21 86.7 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,4ADYR@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver pilG - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_296548_1 338969.Rfer_2914 3.03e-47 159.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,4A9NK@80864|Comamonadaceae 28216|Betaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_296548_2 365046.Rta_07920 1.06e-33 122.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,4AC09@80864|Comamonadaceae 28216|Betaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_338191_1 391735.Veis_1514 1.03e-18 84.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,4ABIN@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_338191_2 1121035.AUCH01000009_gene873 3.41e-67 207.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,2VSNM@28216|Betaproteobacteria,2KWGS@206389|Rhodocyclales 206389|Rhodocyclales F Pyrimidine operon attenuation protein uracil phosphoribosyltransferase pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_153430_1 1123255.JHYS01000003_gene2985 9.08e-26 100.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,4AA23@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_153430_2 614083.AWQR01000018_gene1876 1.24e-31 114.0 2E3TT@1|root,32YR7@2|Bacteria,1N9R9@1224|Proteobacteria,2VW0P@28216|Betaproteobacteria,4AFD6@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_832702_1 1304878.AUGD01000002_gene1856 3.64e-38 141.0 2CHRY@1|root,30Z9E@2|Bacteria,1RGQK@1224|Proteobacteria,2U9J0@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - RecT k59_261544_2 1000565.METUNv1_01293 2.98e-105 317.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,2KV3Y@206389|Rhodocyclales 206389|Rhodocyclales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_298169_1 929562.Emtol_0442 5.08e-68 216.0 COG2367@1|root,COG2367@2|Bacteria,4NDYP@976|Bacteroidetes,47MZ5@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_195627_1 455436.DS989810_gene667 6e-15 74.7 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,4656E@72275|Alteromonadaceae 1236|Gammaproteobacteria S Pyrroloquinoline quinone biosynthesis protein E pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_195627_2 279714.FuraDRAFT_3387 2.81e-28 105.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,2VRTS@28216|Betaproteobacteria 28216|Betaproteobacteria S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_153434_1 266264.Rmet_2819 1.33e-22 95.5 COG2890@1|root,COG2890@2|Bacteria,1MV12@1224|Proteobacteria,2VJVT@28216|Betaproteobacteria,1K32W@119060|Burkholderiaceae 28216|Betaproteobacteria J Pfam Methyltransferase small hemK1 - - - - - - - - - - - MTS k59_153434_2 1000565.METUNv1_02577 1.52e-67 207.0 COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,2VRST@28216|Betaproteobacteria,2KWVR@206389|Rhodocyclales 206389|Rhodocyclales S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_153434_3 243233.MCA1622 7.89e-32 113.0 COG4456@1|root,COG4456@2|Bacteria,1N2HQ@1224|Proteobacteria 1224|Proteobacteria S Virulence-associated protein - - - ko:K18829 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_579944_1 485917.Phep_2955 3.04e-11 63.9 COG3391@1|root,COG3391@2|Bacteria,4NER2@976|Bacteroidetes,1IQ4S@117747|Sphingobacteriia 976|Bacteroidetes M 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase,Phosphoesterase k59_153439_2 614083.AWQR01000030_gene2719 2.15e-46 153.0 COG0071@1|root,COG0071@2|Bacteria,1N535@1224|Proteobacteria,2VVND@28216|Betaproteobacteria,4AF0D@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_545154_1 1000565.METUNv1_00277 2.15e-63 201.0 COG0745@1|root,COG0745@2|Bacteria,1R7VB@1224|Proteobacteria,2VI0D@28216|Betaproteobacteria,2KVAH@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2,Response_reg k59_47062_1 1177154.Y5S_03545 2.03e-108 322.0 28HN1@1|root,2Z7WF@2|Bacteria,1R5H4@1224|Proteobacteria,1RN0K@1236|Gammaproteobacteria,1XN0Z@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_47074_1 596154.Alide2_4454 1.32e-44 155.0 COG0189@1|root,COG0189@2|Bacteria,1QVU3@1224|Proteobacteria,2WH5E@28216|Betaproteobacteria,4AAK1@80864|Comamonadaceae 28216|Betaproteobacteria HJ glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_47074_2 59538.XP_005977027.1 3.79e-37 136.0 COG0014@1|root,KOG4165@2759|Eukaryota,38GA1@33154|Opisthokonta,3B9IB@33208|Metazoa,3CRE1@33213|Bilateria,482X4@7711|Chordata,48ZBW@7742|Vertebrata,3J5RJ@40674|Mammalia,4J54E@91561|Cetartiodactyla 33208|Metazoa E Aldehyde dehydrogenase 18 family member A1 - - - - - - - - - - - - Aldedh k59_758641_1 85643.Tmz1t_0111 1e-241 669.0 COG1672@1|root,COG1672@2|Bacteria,1MWQD@1224|Proteobacteria,2VK8E@28216|Betaproteobacteria,2KVKI@206389|Rhodocyclales 206389|Rhodocyclales S AAA domain - - - - - - - - - - - - AAA_16 k59_1115605_1 749222.Nitsa_1810 1.82e-32 119.0 2C2E9@1|root,32RAA@2|Bacteria,1RF5M@1224|Proteobacteria,433I8@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_47088_1 1000565.METUNv1_00464 1.03e-166 479.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KUWX@206389|Rhodocyclales 206389|Rhodocyclales I Poly(R)-hydroxyalkanoic acid synthase, class I - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_153475_1 1005048.CFU_0185 2.85e-87 266.0 COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,2VJKI@28216|Betaproteobacteria,478DB@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein phnD - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_937205_1 1000565.METUNv1_03581 1.96e-114 344.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2W9QE@28216|Betaproteobacteria,2KZ9H@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_10705_1 1408473.JHXO01000015_gene1925 1.71e-07 59.7 COG2247@1|root,COG2911@1|root,COG4733@1|root,COG2247@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4PHY6@976|Bacteroidetes,2FTM3@200643|Bacteroidia 976|Bacteroidetes M cellulase activity - - - - - - - - - - - - - k59_517083_2 1000565.METUNv1_01215 5.15e-89 266.0 28JV9@1|root,2Z9K8@2|Bacteria,1MVTX@1224|Proteobacteria,2VP25@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_261603_3 745310.G432_05020 3.26e-67 208.0 2DS48@1|root,33EFF@2|Bacteria,1NQPI@1224|Proteobacteria,2UNN0@28211|Alphaproteobacteria,2KAYT@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_446192_1 1074889.MADAR_410 1.26e-06 50.8 COG0234@1|root,COG0234@2|Bacteria,4NS7D@976|Bacteroidetes,1I3WW@117743|Flavobacteriia,3IVJ3@39782|Blattabacteriaceae 976|Bacteroidetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_338294_1 497321.C664_12105 6.55e-51 166.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,2KWAK@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome B561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_338294_2 420662.Mpe_A0353 1.19e-13 72.4 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1KJIN@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_475328_2 1000565.METUNv1_01230 2.25e-40 139.0 COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,2KV78@206389|Rhodocyclales 206389|Rhodocyclales G to the hyi family hfi - 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_517093_2 492774.JQMB01000021_gene3708 2.91e-18 85.1 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE4,EAL,GGDEF,HAMP,PAS_7 k59_614220_1 742767.HMPREF9456_01912 4.53e-54 187.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,2FMBR@200643|Bacteroidia,22WPI@171551|Porphyromonadaceae 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_222150_1 358220.C380_03380 2.06e-114 337.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ACGH@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_222150_2 1122603.ATVI01000012_gene1137 8.13e-09 56.6 COG3687@1|root,COG3687@2|Bacteria,1R8U6@1224|Proteobacteria,1RQUW@1236|Gammaproteobacteria,1X4PI@135614|Xanthomonadales 135614|Xanthomonadales S Predicted metal-dependent hydrolase - - - - - - - - - - - - Metal_hydrol k59_867009_1 614083.AWQR01000030_gene2761 2.07e-99 308.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJD4@28216|Betaproteobacteria,4AD48@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_96710_1 926549.KI421517_gene1960 7.18e-09 62.0 COG1007@1|root,COG1007@2|Bacteria,4NF94@976|Bacteroidetes,47KJD@768503|Cytophagia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1097230_2 1366055.S5M3Y0_9CAUD 9.03e-35 124.0 4QB2U@10239|Viruses,4QVJC@35237|dsDNA viruses no RNA stage,4QTMH@28883|Caudovirales 28883|Caudovirales S Pfam:GTA_holin_3TM - - - - - - - - - - - - - k59_315530_1 1122951.ATUE01000008_gene63 8.88e-61 200.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,3NJGA@468|Moraxellaceae 1236|Gammaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_625037_2 592029.DDD_3235 1.34e-47 156.0 COG3011@1|root,COG3011@2|Bacteria,4NQ93@976|Bacteroidetes,1I30U@117743|Flavobacteriia,3HKF2@363408|Nonlabens 976|Bacteroidetes S Protein of unknown function, DUF393 yuxK - - - - - - - - - - - DUF393 k59_1129014_2 323848.Nmul_A2728 2.33e-05 48.1 COG3211@1|root,COG3211@2|Bacteria,1R690@1224|Proteobacteria,2VMQX@28216|Betaproteobacteria,3725Y@32003|Nitrosomonadales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,VPEP k59_811313_2 1000565.METUNv1_02162 6.73e-48 168.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KVGM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_737582_1 596153.Alide_4552 6.63e-108 315.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,4ACDX@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_882052_1 640081.Dsui_3372 1.27e-47 170.0 28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,2VK1A@28216|Betaproteobacteria,2KVYD@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_24699_1 1166016.W5S_3577 9.48e-08 52.8 COG1396@1|root,COG1396@2|Bacteria,1R7U3@1224|Proteobacteria,1T0MU@1236|Gammaproteobacteria,1MRXA@122277|Pectobacterium 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_847892_1 1173022.Cri9333_1993 1.35e-14 78.6 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_386824_1 395495.Lcho_4134 2.18e-44 155.0 COG3303@1|root,COG3303@2|Bacteria,1RG2D@1224|Proteobacteria,2VRXP@28216|Betaproteobacteria,1KNJI@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_916459_1 93220.LV28_13020 6.69e-24 98.2 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,1K23R@119060|Burkholderiaceae 28216|Betaproteobacteria H 2-dehydropantoate 2-reductase panE2 - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_491446_1 338969.Rfer_0195 7.15e-07 50.8 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,4A9TY@80864|Comamonadaceae 28216|Betaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine rimN - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_491446_2 887062.HGR_16770 1.46e-96 291.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,4AAU4@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1025579_1 472759.Nhal_1225 2.63e-13 70.9 COG2204@1|root,COG5001@1|root,COG2204@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WW1B@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1025579_2 640081.Dsui_0303 2.14e-94 284.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,2KUZN@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_60993_1 748247.AZKH_3613 8.37e-35 127.0 2D326@1|root,32TE3@2|Bacteria,1N94A@1224|Proteobacteria 1224|Proteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_1,Sulfotransfer_3 k59_60993_2 1000565.METUNv1_03763 1e-33 127.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,2KVNW@206389|Rhodocyclales 206389|Rhodocyclales H Capsular polysaccharide biosynthesis protein CapK - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_96761_1 477184.KYC_19909 4.25e-05 51.6 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,3T32D@506|Alcaligenaceae 28216|Betaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N,FliC,FliC_SP k59_276664_1 883126.HMPREF9710_01525 3e-22 93.6 COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,2VVYM@28216|Betaproteobacteria,4756W@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 k59_847918_1 1121035.AUCH01000005_gene60 1.94e-137 405.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KUN3@206389|Rhodocyclales 206389|Rhodocyclales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_24735_1 85643.Tmz1t_2284 8.02e-59 204.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales 206389|Rhodocyclales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_948986_2 1304883.KI912532_gene2342 3.15e-07 53.9 COG0642@1|root,COG2205@2|Bacteria,1R2VB@1224|Proteobacteria 1224|Proteobacteria T protein histidine kinase activity - - - - - - - - - - - - - k59_986994_1 1348657.M622_03030 4.16e-174 500.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VICV@28216|Betaproteobacteria,2KUY2@206389|Rhodocyclales 206389|Rhodocyclales L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_315615_1 1005048.CFU_1483 1.12e-33 125.0 COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2VKZ6@28216|Betaproteobacteria,4742A@75682|Oxalobacteraceae 28216|Betaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA2 - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_315615_2 626418.bglu_1g25480 1.15e-14 70.5 2ADKK@1|root,313B9@2|Bacteria,1RKP2@1224|Proteobacteria,2VSDK@28216|Betaproteobacteria,1K2S2@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1857) - - - - - - - - - - - - DUF1857 k59_625083_1 748247.AZKH_0534 2.47e-123 355.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria,2KUG6@206389|Rhodocyclales 206389|Rhodocyclales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_315623_1 1276756.AUEX01000003_gene795 7.37e-105 312.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,4AC1Q@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family bktB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_315623_2 1504672.669784929 2.43e-27 106.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,4A9SJ@80864|Comamonadaceae 28216|Betaproteobacteria BQ PFAM histone deacetylase superfamily hda - - - - - - - - - - - Hist_deacetyl k59_882158_1 398720.MED217_13811 2.65e-66 212.0 COG0133@1|root,COG0133@2|Bacteria,4NDWP@976|Bacteroidetes,1HXYK@117743|Flavobacteriia,2XIJP@283735|Leeuwenhoekiella 976|Bacteroidetes E Pyridoxal-phosphate dependent enzyme trpB - 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_882164_1 1121413.JMKT01000015_gene253 9e-13 72.4 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria,2MAPG@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM eight transmembrane protein EpsH epsH - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_591981_1 1000565.METUNv1_00201 2.76e-115 347.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJR2@28216|Betaproteobacteria,2KWPD@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - CHASE3,HATPase_c,HisKA_3 k59_61042_1 1349767.GJA_5135 1.52e-53 174.0 2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,2WIH6@28216|Betaproteobacteria,4796W@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF3455) - - - - - - - - - - - - DUF3455 k59_61042_2 749927.AMED_0265 1.62e-12 65.1 COG1522@1|root,COG1522@2|Bacteria,2GQ0S@201174|Actinobacteria,4E4NC@85010|Pseudonocardiales 201174|Actinobacteria K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_1025657_1 365044.Pnap_3557 2.77e-36 132.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,4AE79@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_949033_1 391735.Veis_0437 1.27e-84 252.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,4ADKI@80864|Comamonadaceae 28216|Betaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_949033_2 1276756.AUEX01000001_gene1142 7.27e-45 153.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,4ADQI@80864|Comamonadaceae 28216|Betaproteobacteria S Phosphoribosyl transferase domain comF - - - - - - - - - - - Pribosyltran k59_1067151_1 519989.ECTPHS_04438 1.78e-34 143.0 COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2SI@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_737669_1 1198452.Jab_2c25380 1.86e-121 362.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,473DP@75682|Oxalobacteraceae 28216|Betaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_813125_1 1122201.AUAZ01000035_gene3770 1.94e-16 74.3 2EGFU@1|root,33A7T@2|Bacteria,1NGW0@1224|Proteobacteria,1SGN2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_318401_1 1288494.EBAPG3_29580 5.5e-25 105.0 COG3664@1|root,COG3664@2|Bacteria,1MX9Q@1224|Proteobacteria,2W20Q@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM glycoside hydrolase family 39 - - - - - - - - - - - - - k59_1131205_1 1123504.JQKD01000005_gene4718 7.11e-134 404.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,4AAPA@80864|Comamonadaceae 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_494269_1 1122951.ATUE01000006_gene1501 4.67e-134 395.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,3NJJ4@468|Moraxellaceae 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_885657_1 261292.Nit79A3_3531 2.32e-45 164.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,371QR@32003|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_739745_1 1120980.JQKH01000058_gene1267 1.4e-25 111.0 COG0463@1|root,COG2148@1|root,COG0463@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,2KQD3@206351|Neisseriales 206351|Neisseriales M Psort location CytoplasmicMembrane, score - - 2.7.8.40 ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,Glycos_transf_2,Hexapep k59_390393_1 998674.ATTE01000001_gene2863 2.31e-05 48.5 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,45ZY9@72273|Thiotrichales 72273|Thiotrichales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_279069_1 1458275.AZ34_06320 8.83e-73 234.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VJNN@28216|Betaproteobacteria,4A9S2@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family aldHT - 1.2.1.3 ko:K00128,ko:K22187 ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_390412_1 159087.Daro_0662 1.94e-129 381.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUM4@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_26905_1 1175306.GWL_12910 5.14e-97 291.0 COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VPP7@28216|Betaproteobacteria,4724Q@75682|Oxalobacteraceae 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_739769_1 1121033.AUCF01000001_gene2406 9.96e-89 263.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2JRP3@204441|Rhodospirillales 204441|Rhodospirillales S Polyhydroxyalkanoate synthesis repressor - - - - - - - - - - - - PHB_acc,PHB_acc_N k59_170383_2 1408813.AYMG01000012_gene1039 5.56e-12 66.2 COG1629@1|root,COG1629@2|Bacteria,4NH4T@976|Bacteroidetes,1IQJD@117747|Sphingobacteriia 976|Bacteroidetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_739773_1 748280.NH8B_1815 3.36e-71 224.0 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,2VKPU@28216|Betaproteobacteria,2KS8N@206351|Neisseriales 206351|Neisseriales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_850647_1 1282356.H045_13075 1.02e-09 58.9 COG2198@1|root,COG2198@2|Bacteria,1NBYP@1224|Proteobacteria,1SCGW@1236|Gammaproteobacteria,1YQZ3@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T Histidine Phosphotransfer domain hptB - - ko:K20976 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - Hpt k59_563957_1 1500890.JQNL01000001_gene2305 3.74e-37 146.0 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,1T1MJ@1236|Gammaproteobacteria,1X4X8@135614|Xanthomonadales 135614|Xanthomonadales U Autotransporter beta-domain yapH - - - - - - - - - - - ESPR,PATR k59_418084_1 1163407.UU7_07516 1.25e-89 289.0 COG3587@1|root,COG3587@2|Bacteria,1QUSI@1224|Proteobacteria,1T4KI@1236|Gammaproteobacteria 1236|Gammaproteobacteria V type III restriction enzyme, res subunit - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - ResIII k59_918522_1 1337093.MBE-LCI_1180 1.18e-07 58.2 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,2P873@245186|Loktanella 28211|Alphaproteobacteria C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_850661_1 1502770.JQMG01000001_gene2 8.17e-08 60.8 COG2304@1|root,COG2931@1|root,COG5295@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria 28216|Betaproteobacteria Q TIGRFAM outer membrane adhesin like proteiin - - - - - - - - - - - - Cadherin_3,DUF4347,He_PIG,HemolysinCabind,VWA_2 k59_494359_1 1297569.MESS2_50078 1.8e-38 132.0 COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,2UEUU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_134337_1 1198452.Jab_1c12670 4.56e-114 336.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,476XT@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II/IV secretion system protein - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_593896_1 159087.Daro_1056 2.87e-95 287.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,2KVDU@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 transport system, periplasmic component - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_950888_2 338969.Rfer_2608 1.18e-47 164.0 COG2199@1|root,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,2WEF3@28216|Betaproteobacteria,4ADFW@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_418107_1 1163408.UU9_12867 2.01e-35 130.0 COG2863@1|root,COG2863@2|Bacteria,1RGTS@1224|Proteobacteria,1S4NI@1236|Gammaproteobacteria,1X63V@135614|Xanthomonadales 135614|Xanthomonadales C Cytochrome - - - - - - - - - - - - Cytochrom_C k59_418107_2 1504672.669783283 4.47e-06 49.7 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VH58@28216|Betaproteobacteria,4AB0M@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cytochrom_C k59_418109_1 580332.Slit_2195 1.62e-27 115.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_563999_1 1122603.ATVI01000010_gene1066 8.27e-20 90.9 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,1X41W@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_38570_1 338969.Rfer_3865 6.67e-08 52.8 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,4A9SD@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_38570_2 614083.AWQR01000009_gene698 6.05e-90 281.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,4A9UJ@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_145125_1 614083.AWQR01000026_gene3557 1.15e-41 146.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,4ADW3@80864|Comamonadaceae 28216|Betaproteobacteria P SMART Rhodanese domain protein - - - - - - - - - - - - Lactamase_B,Rhodanese k59_359885_1 1000565.METUNv1_02122 1.5e-54 186.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,2KUT7@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase yfhK - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_751839_1 748247.AZKH_0433 4.04e-05 47.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,2KXXX@206389|Rhodocyclales 206389|Rhodocyclales C Aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_751839_2 1000565.METUNv1_00077 3.54e-51 172.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KUFP@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_109461_1 398578.Daci_2155 1.17e-163 471.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4AA1A@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family rhlE2 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_109461_2 397945.Aave_1147 6.46e-21 89.4 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,4AA6V@80864|Comamonadaceae 28216|Betaproteobacteria S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_466616_1 1276756.AUEX01000005_gene2662 7.2e-69 224.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_466616_2 232721.Ajs_3907 6.58e-99 295.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,4AAM5@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_680350_1 1144319.PMI16_01360 2.48e-153 449.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,475WM@75682|Oxalobacteraceae 28216|Betaproteobacteria EQ Hydantoinase B/oxoprolinase oplaH - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_503436_1 1000565.METUNv1_03771 1.41e-83 254.0 COG4424@1|root,COG4424@2|Bacteria,1QVF4@1224|Proteobacteria,2VMVK@28216|Betaproteobacteria,2KY2S@206389|Rhodocyclales 206389|Rhodocyclales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_503436_2 1000565.METUNv1_03770 4.92e-99 296.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,2VUX2@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_transf_7C,Glycos_transf_2,PIG-L k59_823363_1 614083.AWQR01000005_gene1161 1.44e-105 309.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,4ABJC@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related aapP - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_216415_1 757424.Hsero_3132 1.25e-13 75.5 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJ7P@28216|Betaproteobacteria,4760X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_216416_1 1276756.AUEX01000037_gene290 9.31e-37 133.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,4ABX2@80864|Comamonadaceae 28216|Betaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_216416_2 944435.AXAJ01000004_gene2158 6.34e-24 99.8 COG0596@1|root,COG0596@2|Bacteria,1QTWQ@1224|Proteobacteria,2WGGA@28216|Betaproteobacteria,1K2V9@119060|Burkholderiaceae 28216|Betaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_608632_1 1000565.METUNv1_03783 4.31e-226 642.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,2VIZD@28216|Betaproteobacteria,2KV0R@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HATPase_c k59_608632_2 545276.KB898732_gene2406 1.07e-10 61.2 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1WWWA@135613|Chromatiales 135613|Chromatiales M Sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_182037_1 265072.Mfla_1493 8.95e-35 127.0 COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,2VI3V@28216|Betaproteobacteria,2KMQF@206350|Nitrosomonadales 206350|Nitrosomonadales T Low molecular weight phosphatase family - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_182037_2 159087.Daro_2636 1.89e-103 308.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales 28216|Betaproteobacteria P COG0798 Arsenite efflux pump ACR3 and related permeases - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_680358_1 1348657.M622_08555 1.29e-06 48.9 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,2KUDP@206389|Rhodocyclales 206389|Rhodocyclales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_680358_2 640081.Dsui_3197 9.3e-82 252.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,2KU88@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1074611_1 1000565.METUNv1_01840 0.0 1592.0 COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria,2KVVQ@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1074611_2 1000565.METUNv1_01839 1.98e-173 488.0 COG2197@1|root,COG2197@2|Bacteria,1MVNV@1224|Proteobacteria,2VH9E@28216|Betaproteobacteria,2KVF5@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_1074611_3 375286.mma_0907 1.1e-15 75.1 2DKJT@1|root,309RD@2|Bacteria,1R36E@1224|Proteobacteria,2VRFQ@28216|Betaproteobacteria,477CC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Chlorite dismutase - - - - - - - - - - - - Chlor_dismutase k59_895122_1 1000565.METUNv1_01863 1.06e-152 446.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,2KUEG@206389|Rhodocyclales 206389|Rhodocyclales M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_1037959_1 864051.BurJ1DRAFT_4350 1.94e-112 341.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,1KIT0@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_2522_1 1000565.METUNv1_03252 1.06e-141 408.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,2KV12@206389|Rhodocyclales 206389|Rhodocyclales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_395550_1 338969.Rfer_4118 1.27e-29 119.0 COG0374@1|root,COG0374@2|Bacteria,1R6ND@1224|Proteobacteria,2VQXM@28216|Betaproteobacteria,4AFPV@80864|Comamonadaceae 28216|Betaproteobacteria C Ni,Fe-hydrogenase I large subunit hoxV - - - - - - - - - - - NiFeSe_Hases k59_1001769_2 1123392.AQWL01000002_gene2071 1.82e-33 124.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VQAV@28216|Betaproteobacteria,1KSQ0@119069|Hydrogenophilales 119069|Hydrogenophilales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_788290_1 1000565.METUNv1_00885 2.11e-14 72.4 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria 28216|Betaproteobacteria S aminopeptidase - - - - - - - - - - - - Aminopep k59_788290_2 1123269.NX02_00420 1.23e-58 188.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,2K25N@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_930020_1 1157708.KB907464_gene447 1.97e-36 130.0 COG0640@1|root,COG0640@2|Bacteria,1MWCW@1224|Proteobacteria,2VQYZ@28216|Betaproteobacteria,4AJIR@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 k59_930020_2 1157708.KB907464_gene446 6.78e-27 109.0 COG2124@1|root,COG2124@2|Bacteria,1RA4D@1224|Proteobacteria,2VQ8P@28216|Betaproteobacteria,4ADYJ@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_395558_1 1000565.METUNv1_00310 1.12e-78 242.0 2D5F0@1|root,32TIY@2|Bacteria,1N1FC@1224|Proteobacteria,2VYG3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_646263_1 666681.M301_1786 1.19e-96 289.0 COG4359@1|root,COG4359@2|Bacteria,1REUD@1224|Proteobacteria,2VJXZ@28216|Betaproteobacteria,2KNSD@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM HAD-superfamily hydrolase subfamily IB - - - - - - - - - - - - - k59_252799_2 1278971.AOGF01000034_gene1742 3.36e-16 78.2 2DZDP@1|root,32V80@2|Bacteria,1NFT2@1224|Proteobacteria,1SDI2@1236|Gammaproteobacteria,1YAC1@135625|Pasteurellales 135625|Pasteurellales - - Z012_02125 - - - - - - - - - - - - k59_895141_1 1000565.METUNv1_02528 1.01e-205 601.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2VJF3@28216|Betaproteobacteria,2KW03@206389|Rhodocyclales 206389|Rhodocyclales L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_38629_1 948106.AWZT01000001_gene5329 1.73e-23 104.0 2ADGG@1|root,3136M@2|Bacteria,1PRWM@1224|Proteobacteria,2WA1H@28216|Betaproteobacteria,1K1KW@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_38629_2 987059.RBXJA2T_02497 1.82e-103 313.0 COG0382@1|root,COG0560@1|root,COG0382@2|Bacteria,COG0560@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,1KMY2@119065|unclassified Burkholderiales 28216|Betaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - HAD,UbiA k59_431968_1 312284.A20C1_11829 5.34e-09 62.8 COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,3UWS3@52018|unclassified Actinobacteria (class) 201174|Actinobacteria I Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - Acyl_transf_3 k59_716842_2 381666.H16_A0009 1.51e-103 313.0 COG4268@1|root,COG4268@2|Bacteria,1PK1W@1224|Proteobacteria,2W8CQ@28216|Betaproteobacteria,1KEU6@119060|Burkholderiaceae 28216|Betaproteobacteria V McrBC 5-methylcytosine restriction system component - - - ko:K19147 - - - - ko00000,ko02048 - - - McrBC k59_38635_1 981369.JQMJ01000004_gene6222 1.25e-11 68.9 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,2NGK6@228398|Streptacidiphilus 201174|Actinobacteria T Transcriptional regulatory protein, C terminal - - - ko:K07669,ko:K07672 ko02020,map02020 M00460,M00463 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1074649_4 1000565.METUNv1_01617 8.72e-24 98.6 COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,2VTKH@28216|Betaproteobacteria,2KZHD@206389|Rhodocyclales 206389|Rhodocyclales S Fic/DOC family - - - - - - - - - - - - Fic k59_1074649_5 1000565.METUNv1_01618 3.79e-17 73.9 2CC2C@1|root,32U71@2|Bacteria,1N3IW@1224|Proteobacteria,2VVH1@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1074649_6 1255043.TVNIR_2283 2.98e-28 103.0 COG4456@1|root,COG4456@2|Bacteria,1N85E@1224|Proteobacteria,1SH20@1236|Gammaproteobacteria,1X1TX@135613|Chromatiales 135613|Chromatiales S Antidote-toxin recognition MazE, bacterial antitoxin - - - ko:K18829 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_324964_1 1000565.METUNv1_03398 3.85e-50 166.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,2KW31@206389|Rhodocyclales 206389|Rhodocyclales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_6,TolA_bind_tri k59_324964_2 1000565.METUNv1_03399 4.74e-132 378.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KVAA@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_324964_3 1000565.METUNv1_03400 1.27e-130 382.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_288518_1 498211.CJA_0768 1.42e-48 164.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1FGU2@10|Cellvibrio 1236|Gammaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_503502_1 1095769.CAHF01000003_gene1016 1.53e-37 137.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,472CJ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_503502_2 1005048.CFU_0502 1.23e-34 132.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,4723Z@75682|Oxalobacteraceae 28216|Betaproteobacteria E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_788319_1 1000565.METUNv1_03755 3.13e-22 93.6 COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2VNEW@28216|Betaproteobacteria,2KVBP@206389|Rhodocyclales 206389|Rhodocyclales V Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_788319_2 1000565.METUNv1_03754 4.05e-176 493.0 COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,2VIB9@28216|Betaproteobacteria,2KU7E@206389|Rhodocyclales 206389|Rhodocyclales G polysaccharide deactylase family protein - - - - - - - - - - - - DUF3473,Polysacc_deac_1 k59_1001788_1 1000565.METUNv1_03047 5.38e-278 779.0 COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2VMGW@28216|Betaproteobacteria,2KVV8@206389|Rhodocyclales 206389|Rhodocyclales M Transglycosylase - - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase k59_1001788_2 1000565.METUNv1_03046 1.32e-64 199.0 COG0720@1|root,COG0720@2|Bacteria,1PSH6@1224|Proteobacteria,2VUV7@28216|Betaproteobacteria,2KZ2A@206389|Rhodocyclales 206389|Rhodocyclales H 6-pyruvoyl tetrahydropterin synthase - - - - - - - - - - - - PTPS k59_646301_2 1000565.METUNv1_01201 3.31e-89 265.0 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,2VW1U@28216|Betaproteobacteria,2KXP0@206389|Rhodocyclales 206389|Rhodocyclales NU PilX N-terminal - - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_751894_1 720554.Clocl_2659 1.24e-41 159.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,24EGZ@186801|Clostridia,3WI6H@541000|Ruminococcaceae 186801|Clostridia Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_823407_2 1201290.M902_0616 1.73e-31 114.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2MUAU@213481|Bdellovibrionales,2WPSJ@28221|Deltaproteobacteria 213481|Bdellovibrionales S Belongs to the UPF0178 family yaiI - - ko:K09768 - - - - ko00000 - - - DUF188 k59_288541_1 1094980.Mpsy_1718 4.28e-34 133.0 arCOG02342@1|root,arCOG02349@1|root,arCOG02342@2157|Archaea,arCOG02349@2157|Archaea,2Y7NW@28890|Euryarchaeota,2NAB7@224756|Methanomicrobia 224756|Methanomicrobia T Pfam:Cache_1 - - - - - - - - - - - - HATPase_c,HisKA_2,PAS_3,dCache_1 k59_288541_2 1408433.JHXV01000015_gene1712 7.64e-22 91.3 COG3279@1|root,COG3279@2|Bacteria,4NKXC@976|Bacteroidetes,1I0BK@117743|Flavobacteriia,2PAUQ@246874|Cryomorphaceae 976|Bacteroidetes K Response regulator of the LytR AlgR family - - - - - - - - - - - - LytTR,Response_reg k59_109537_1 338969.Rfer_0716 2.83e-107 320.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2VIF1@28216|Betaproteobacteria,4AD4G@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Acetyl-CoA hydrolase transferase - - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_646314_1 1336243.JAEA01000010_gene3391 3.95e-29 113.0 COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TTW8@28211|Alphaproteobacteria,1JUDB@119045|Methylobacteriaceae 28211|Alphaproteobacteria P PFAM NMT1 THI5 like MA20_40330 - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_1074682_1 930169.B5T_02486 1.5e-08 61.2 COG3391@1|root,COG3509@1|root,COG3391@2|Bacteria,COG3509@2|Bacteria,1QX6H@1224|Proteobacteria,1T3DD@1236|Gammaproteobacteria,1XP6B@135619|Oceanospirillales 135619|Oceanospirillales Q Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 k59_432015_1 1198452.Jab_2c15860 6.98e-118 372.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,2VKQ5@28216|Betaproteobacteria,476ZU@75682|Oxalobacteraceae 28216|Betaproteobacteria L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_858848_1 397945.Aave_2210 6.02e-126 382.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2VHT2@28216|Betaproteobacteria,4A9NW@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_788331_1 572477.Alvin_2334 9.1e-09 67.8 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG2202@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_1001800_1 159087.Daro_1018 3.57e-123 371.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,2KVFW@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase/oxoprolinase N-terminal region acxA - 6.4.1.6 ko:K10855 - - - - ko00000,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_252849_2 1287276.X752_05280 1.87e-47 159.0 COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,2U8QT@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_182132_1 93220.LV28_00675 4.94e-90 273.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae 28216|Betaproteobacteria P Phosphate transporter pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_859443_1 1538295.JY96_18695 1.09e-131 385.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VHNP@28216|Betaproteobacteria,1KJFU@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_1109383_1 983917.RGE_10830 3.26e-96 286.0 COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VPIW@28216|Betaproteobacteria,1KJDM@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the glycosyltransferase 26 family tagA - 2.4.1.187 ko:K05946,ko:K13660 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB,STAS_2 k59_289420_1 1000565.METUNv1_01195 1.27e-84 278.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_253627_1 1000565.METUNv1_03846 4.08e-180 509.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales 206389|Rhodocyclales H enzyme of heme biosynthesis hemY - - ko:K02498 - - - - ko00000 - - - HemY_N k59_183108_1 95619.PM1_0203450 3.37e-43 159.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_896097_1 1000565.METUNv1_02266 2.44e-08 51.6 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KWRX@206389|Rhodocyclales 206389|Rhodocyclales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_896097_2 1000565.METUNv1_02265 2.05e-125 358.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,2KVFP@206389|Rhodocyclales 206389|Rhodocyclales J 50S ribosomal protein L4 rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_896097_3 1000565.METUNv1_02264 1.19e-91 271.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,2KV3R@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1085310_10 439375.Oant_0213 1.05e-31 130.0 COG0468@1|root,COG0468@2|Bacteria,1PK58@1224|Proteobacteria,2UB77@28211|Alphaproteobacteria 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_24 k59_830761_1 1000565.METUNv1_02833 4.61e-183 513.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KV8E@206389|Rhodocyclales 206389|Rhodocyclales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_296008_1 1123367.C666_03215 7.2e-85 276.0 COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,2KY1X@206389|Rhodocyclales 206389|Rhodocyclales E Peptidase M1 membrane alanine aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_442660_1 595537.Varpa_3283 2.41e-29 115.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,4ABKN@80864|Comamonadaceae 28216|Betaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_442660_2 614083.AWQR01000031_gene2587 1.18e-20 86.7 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,4AA9V@80864|Comamonadaceae 28216|Betaproteobacteria U Mota tolq exbb proton channel exbB2 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_45098_1 1198452.Jab_2c33080 6.47e-111 340.0 COG4772@1|root,COG4772@2|Bacteria,1QUXZ@1224|Proteobacteria 1224|Proteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_543027_1 397945.Aave_1746 1.82e-74 246.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,1R7CK@1224|Proteobacteria,2VM2P@28216|Betaproteobacteria 28216|Betaproteobacteria H PFAM DNA methylase N-4 N-6 domain protein - - - - - - - - - - - - N6_N4_Mtase k59_296010_1 527002.yaldo0001_25040 3.83e-12 70.5 COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,1RS3Y@1236|Gammaproteobacteria,41FWD@629|Yersinia 1236|Gammaproteobacteria H Belongs to the carbohydrate kinase PfkB family pfkB GO:0000287,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008443,GO:0009024,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11 ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_793,iUTI89_1310.UTI89_C1916 PfkB k59_971098_1 640081.Dsui_2123 4.67e-81 249.0 COG2200@1|root,COG2200@2|Bacteria,1RM23@1224|Proteobacteria,2VSFS@28216|Betaproteobacteria,2KZUA@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL k59_151050_2 318829.MGG_07750T0 2.82e-05 47.8 29U1Q@1|root,2RXHP@2759|Eukaryota,3AFCJ@33154|Opisthokonta,3PB2W@4751|Fungi,3QKXE@4890|Ascomycota,214AF@147550|Sordariomycetes 4751|Fungi S RNA ligase - - - - - - - - - - - - RNA_ligase k59_296018_1 930169.B5T_01454 1.73e-90 276.0 COG3239@1|root,COG3239@2|Bacteria,1QKDT@1224|Proteobacteria,1RQCX@1236|Gammaproteobacteria,1XNQW@135619|Oceanospirillales 135619|Oceanospirillales I fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_830775_1 1123504.JQKD01000026_gene4279 3.09e-106 333.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,4A9XE@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1085343_1 296591.Bpro_4900 6.9e-124 374.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,4AABC@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_656984_1 1179778.PMM47T1_26757 2.55e-81 256.0 COG2208@1|root,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,1RMG2@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT PFAM Stage II sporulation E family protein - - - - - - - - - - - - CBS,SpoIIE k59_334994_1 1121939.L861_02445 2.73e-38 139.0 COG0673@1|root,COG0673@2|Bacteria,1RJ53@1224|Proteobacteria 1224|Proteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_45110_1 62928.azo2523 1.14e-54 173.0 COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2VSU2@28216|Betaproteobacteria,2KYSN@206389|Rhodocyclales 206389|Rhodocyclales S Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_656989_2 1000565.METUNv1_02234 9.35e-48 170.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria,2KW15@206389|Rhodocyclales 206389|Rhodocyclales M Sulfatase - - - - - - - - - - - - Sulfatase k59_474156_1 983917.RGE_20950 4.91e-104 318.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria,1KP4U@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS k59_831748_1 1000565.METUNv1_01295 2.27e-116 342.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,2KW5H@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_831748_2 1266925.JHVX01000003_gene471 3.19e-15 73.9 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,3721N@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_903284_1 1000565.METUNv1_01934 1.77e-151 435.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KVC9@206389|Rhodocyclales 206389|Rhodocyclales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_444423_1 1198452.Jab_1c24730 2.68e-29 107.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,4743K@75682|Oxalobacteraceae 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_444423_2 1198452.Jab_1c24720 4.73e-38 141.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,475I6@75682|Oxalobacteraceae 28216|Betaproteobacteria EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_336581_1 626418.bglu_1g22550 4.83e-12 67.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K1BU@119060|Burkholderiaceae 28216|Betaproteobacteria NT Chemotaxis sensory transducer - - - ko:K03406,ko:K03776,ko:K05874,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_336581_2 1157708.KB907450_gene6170 4.36e-08 52.4 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria,4AA0S@80864|Comamonadaceae 28216|Betaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_46091_1 95619.PM1_0221145 5.66e-67 215.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 k59_368010_1 925409.KI911562_gene155 4.81e-16 75.5 COG0640@1|root,COG0640@2|Bacteria,4NS23@976|Bacteroidetes,1IT8B@117747|Sphingobacteriia 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_DeoR k59_613469_3 479433.Caci_3032 5.37e-18 87.0 COG4333@1|root,COG4333@2|Bacteria,2GTHH@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1643) - - - - - - - - - - - - DUF1643 k59_1010117_1 930166.CD58_17475 2.7e-67 212.0 COG0845@1|root,COG0845@2|Bacteria,1R99C@1224|Proteobacteria,1RZS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_544100_1 1000565.METUNv1_02592 4.72e-36 130.0 COG3678@1|root,COG3678@2|Bacteria,1NBYM@1224|Proteobacteria,2VXG9@28216|Betaproteobacteria 28216|Betaproteobacteria NPTU Heavy-metal resistance - - - - - - - - - - - - LTXXQ,Metal_resist k59_972008_2 1000565.METUNv1_02165 7.9e-24 98.2 COG0596@1|root,COG0596@2|Bacteria,1QTTM@1224|Proteobacteria,2WGQ4@28216|Betaproteobacteria,2KXIW@206389|Rhodocyclales 206389|Rhodocyclales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_9659_1 614083.AWQR01000020_gene192 1.26e-90 272.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2VRTK@28216|Betaproteobacteria,4ACHD@80864|Comamonadaceae 28216|Betaproteobacteria D Belongs to the ParA family fleN - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA k59_1086975_1 1000565.METUNv1_02402 7.56e-100 305.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KVHE@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_658796_1 1198452.Jab_2c03340 7.46e-216 607.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2VN7E@28216|Betaproteobacteria,475HV@75682|Oxalobacteraceae 28216|Betaproteobacteria U POT family - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_9673_1 879212.DespoDRAFT_03347 4.98e-22 94.4 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,42T54@68525|delta/epsilon subdivisions,2WQRG@28221|Deltaproteobacteria,2MKGG@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_9673_2 522306.CAP2UW1_0857 4.86e-48 171.0 COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,2VX6D@28216|Betaproteobacteria 28216|Betaproteobacteria S Heparinase II - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_81458_1 522306.CAP2UW1_0844 2.74e-58 191.0 2DKYH@1|root,30WKQ@2|Bacteria,1RCXC@1224|Proteobacteria,2VR6P@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM EpsI family protein - - - - - - - - - - - - DUF3485 k59_444527_1 1037409.BJ6T_20600 6.32e-30 116.0 COG3916@1|root,COG3916@2|Bacteria,1R87K@1224|Proteobacteria,2TVRZ@28211|Alphaproteobacteria,3K6JZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria QT Autoinducer synthase - - 2.3.1.184 ko:K13060 ko00270,ko01100,ko02024,ko02025,map00270,map01100,map02024,map02025 - R08940 RC00021,RC00039 ko00000,ko00001,ko01000 - - - Autoind_synth k59_1044813_1 1237149.C900_03218 1.53e-06 48.9 COG1028@1|root,COG1028@2|Bacteria,4NICN@976|Bacteroidetes,47JB0@768503|Cytophagia 976|Bacteroidetes IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1044813_2 762903.Pedsa_1200 3.38e-37 135.0 COG1011@1|root,COG1011@2|Bacteria,4NQT8@976|Bacteroidetes,1IS3Y@117747|Sphingobacteriia 976|Bacteroidetes S HAD-superfamily hydrolase subfamily IA, variant 3 yihX - 3.1.3.10 ko:K20866 ko00010,ko01120,map00010,map01120 - R00947 RC00078 ko00000,ko00001,ko01000 - - - HAD_2 k59_297151_2 272568.GDI3670 7.95e-98 328.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria,2UM25@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_297151_3 1226322.HMPREF1545_02859 2.73e-18 94.7 COG5362@1|root,COG5362@2|Bacteria,1TSQB@1239|Firmicutes,24ACE@186801|Clostridia 186801|Clostridia S TIGRFAM Phage - - - - - - - - - - - - - k59_81471_1 1000565.METUNv1_02560 3.68e-97 294.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,2KUJ7@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_46153_2 1198452.Jab_1c12350 7.74e-80 245.0 COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,47311@75682|Oxalobacteraceae 28216|Betaproteobacteria F Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH k59_865906_1 365046.Rta_21010 4.58e-40 143.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,4AB8Q@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_865906_2 338969.Rfer_2045 7.88e-37 134.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,4AAT0@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Type II secretion system protein E pilT2 - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1087036_1 582744.Msip34_1022 2.24e-17 82.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2VKXB@28216|Betaproteobacteria,2KMI3@206350|Nitrosomonadales 206350|Nitrosomonadales P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_444561_1 159087.Daro_0675 4.73e-81 265.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_194169_1 1000565.METUNv1_03029 2.39e-64 213.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUI4@206389|Rhodocyclales 206389|Rhodocyclales P COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_936399_1 46234.ANA_C13154 5.41e-95 290.0 COG0399@1|root,COG0399@2|Bacteria,1G0XH@1117|Cyanobacteria,1HR4E@1161|Nostocales 1117|Cyanobacteria M DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_402889_1 1304883.KI912532_gene2664 1.08e-29 123.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales 206389|Rhodocyclales CM Acyl-CoA synthetase (NDP forming) - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_796181_1 399739.Pmen_2006 1.2e-42 150.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1RPPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_658868_1 290400.Jann_1557 4.11e-53 187.0 COG2340@1|root,COG5549@1|root,COG2340@2|Bacteria,COG5549@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF4214 k59_831844_1 1122951.ATUE01000005_gene1639 3.93e-96 291.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,3NJYF@468|Moraxellaceae 1236|Gammaproteobacteria C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_444575_1 1000565.METUNv1_00339 7.47e-46 162.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,2KUEF@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_152304_1 614083.AWQR01000053_gene3396 8.78e-65 204.0 COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,4AE27@80864|Comamonadaceae 28216|Betaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_152304_2 614083.AWQR01000005_gene1217 6.21e-14 68.9 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,4AAQ9@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - Hemerythrin,PNP_phzG_C,Putative_PNPOx k59_972064_1 614083.AWQR01000034_gene3568 6.2e-89 282.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,4AA54@80864|Comamonadaceae 28216|Betaproteobacteria CO PFAM cytochrome c biogenesis protein, transmembrane region - - 1.8.1.8 ko:K04084,ko:K08344 - - - - ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.5 - - DsbC,DsbD,Thioredoxin_7 k59_972064_2 1123255.JHYS01000005_gene788 0.000261 42.4 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,4AEJ7@80864|Comamonadaceae 28216|Betaproteobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_936410_1 83406.HDN1F_04190 1.18e-149 430.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alkane 1-monooxygenase - - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase,Rubredoxin k59_194204_1 1000565.METUNv1_02636 3.17e-77 238.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2VKC4@28216|Betaproteobacteria,2KV6P@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_194204_2 1000565.METUNv1_02637 2.05e-12 64.3 COG3418@1|root,COG3418@2|Bacteria,1NGUP@1224|Proteobacteria,2VXS1@28216|Betaproteobacteria,2KXI1@206389|Rhodocyclales 206389|Rhodocyclales N FlgN protein - - - ko:K02399 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgN k59_579223_1 614083.AWQR01000020_gene181 3.11e-138 412.0 COG1181@1|root,COG1181@2|Bacteria,1QWAW@1224|Proteobacteria,2VITI@28216|Betaproteobacteria,4ABKK@80864|Comamonadaceae 28216|Betaproteobacteria M RimK-like ATP-grasp domain cphA2 - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_221350_1 157783.LK03_14275 2.5e-45 163.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,1RMA1@1236|Gammaproteobacteria 1236|Gammaproteobacteria E ABC-type oligopeptide transport system, periplasmic component yejA GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042493,GO:0042597,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_221350_2 1415778.JQMM01000001_gene1910 6.03e-07 53.9 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1J524@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_936412_1 1000565.METUNv1_02767 6.41e-106 313.0 COG1639@1|root,COG1639@2|Bacteria,1R4ZN@1224|Proteobacteria,2VQ1P@28216|Betaproteobacteria,2KVUP@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_763970_1 1000565.METUNv1_01598 4.31e-65 201.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,2KWMD@206389|Rhodocyclales 206389|Rhodocyclales O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_763970_2 1000565.METUNv1_01597 3.96e-251 703.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,2KUNW@206389|Rhodocyclales 206389|Rhodocyclales O Cytochrome c ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_16891_2 1458427.BAWN01000004_gene155 8.62e-13 67.4 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,2VH5G@28216|Betaproteobacteria,4AJ0N@80864|Comamonadaceae 28216|Betaproteobacteria S Fic/DOC family - - - - - - - - - - - - Fic k59_408863_1 1304883.KI912532_gene1280 6.31e-158 450.0 COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2VJB9@28216|Betaproteobacteria,2KURI@206389|Rhodocyclales 206389|Rhodocyclales P membrane protein, TerC - - - ko:K05794 - - - - ko00000 - - - TerC k59_763973_1 1000565.METUNv1_02750 1.23e-123 355.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,2KU8F@206389|Rhodocyclales 206389|Rhodocyclales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_1092229_1 316055.RPE_3261 9.78e-160 460.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_670552_1 1198452.Jab_1c10720 3.67e-37 143.0 COG2203@1|root,COG3292@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,475JP@75682|Oxalobacteraceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Reg_prop,Y_Y_Y k59_53292_1 338969.Rfer_3493 7.54e-103 315.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,4AAVU@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_268317_1 204773.HEAR2914 1.54e-06 46.2 2E53D@1|root,32ZWH@2|Bacteria,1N979@1224|Proteobacteria,2VVRY@28216|Betaproteobacteria,4750N@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_268317_2 757424.Hsero_4157 7.32e-92 275.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,4735S@75682|Oxalobacteraceae 28216|Betaproteobacteria C Heme copper-type cytochrome quinol oxidase, subunit 3 coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1054996_1 1123502.AQXD01000002_gene539 1.07e-63 214.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XDGM@135614|Xanthomonadales 135614|Xanthomonadales V Peptidase C39 family - - - - - - - - - - - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1054996_2 172088.AUGA01000011_gene2702 1.31e-13 73.6 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TTX9@28211|Alphaproteobacteria,3JRHM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M TIGRFAM type I secretion membrane fusion protein, HlyD family - - - ko:K02022,ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_305577_2 1144342.PMI40_03626 8.15e-47 162.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,472SE@75682|Oxalobacteraceae 28216|Betaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_979226_1 1004785.AMBLS11_07380 5.72e-18 85.9 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria,466IR@72275|Alteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,LapD_MoxY_N k59_979226_2 1278309.KB907102_gene8 3.36e-11 64.7 COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,1RQWW@1236|Gammaproteobacteria,1XIRH@135619|Oceanospirillales 135619|Oceanospirillales M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_763994_1 59538.XP_005975314.1 2.18e-122 363.0 COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3BCEE@33208|Metazoa,3CU79@33213|Bilateria,489CP@7711|Chordata,497ZQ@7742|Vertebrata,3J34Z@40674|Mammalia,4J1PP@91561|Cetartiodactyla 33208|Metazoa C ATP synthase, H transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle ATP5A1 - - ko:K02132 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_527313_1 243231.GSU1154 4.79e-23 108.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,43C4H@68525|delta/epsilon subdivisions,2X7EX@28221|Deltaproteobacteria 28221|Deltaproteobacteria U domain, Protein - - - - - - - - - - - - - k59_305589_1 1198452.Jab_2c33360 1.69e-09 54.3 2C5KN@1|root,302D6@2|Bacteria,1PV6X@1224|Proteobacteria,2WB4J@28216|Betaproteobacteria,47501@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_305589_2 1198452.Jab_2c33370 2.38e-95 285.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,2VH2Y@28216|Betaproteobacteria,475J6@75682|Oxalobacteraceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_838651_1 10224.XP_002738747.1 8.59e-26 102.0 KOG0084@1|root,KOG0084@2759|Eukaryota,38DXZ@33154|Opisthokonta,3BEKS@33208|Metazoa,3CWWC@33213|Bilateria 33208|Metazoa U GTPase activity RAB1A GO:0000003,GO:0000045,GO:0000139,GO:0000166,GO:0000278,GO:0000280,GO:0000281,GO:0000407,GO:0000902,GO:0000904,GO:0000910,GO:0001816,GO:0001882,GO:0001883,GO:0002790,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006890,GO:0006897,GO:0006900,GO:0006901,GO:0006903,GO:0006914,GO:0006928,GO:0006950,GO:0006952,GO:0006996,GO:0007017,GO:0007018,GO:0007030,GO:0007033,GO:0007049,GO:0007112,GO:0007140,GO:0007154,GO:0007155,GO:0007165,GO:0007264,GO:0007265,GO:0007267,GO:0007275,GO:0007276,GO:0007399,GO:0008088,GO:0008089,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009306,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009893,GO:0009894,GO:0009914,GO:0009987,GO:0010256,GO:0010506,GO:0010604,GO:0010646,GO:0010647,GO:0010720,GO:0010769,GO:0010770,GO:0010817,GO:0010970,GO:0010975,GO:0010976,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016043,GO:0016050,GO:0016192,GO:0016236,GO:0016241,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019058,GO:0019068,GO:0019222,GO:0019538,GO:0019953,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023056,GO:0023061,GO:0030072,GO:0030133,GO:0030154,GO:0030252,GO:0030334,GO:0030658,GO:0030659,GO:0030705,GO:0031090,GO:0031323,GO:0031325,GO:0031329,GO:0031344,GO:0031346,GO:0031396,GO:0031398,GO:0031399,GO:0031401,GO:0031410,GO:0031589,GO:0031982,GO:0031984,GO:0032024,GO:0032153,GO:0032154,GO:0032155,GO:0032268,GO:0032270,GO:0032400,GO:0032401,GO:0032402,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032637,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0033036,GO:0033043,GO:0033059,GO:0033116,GO:0033206,GO:0033365,GO:0033500,GO:0034045,GO:0034067,GO:0034446,GO:0034613,GO:0034622,GO:0035459,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0040011,GO:0040012,GO:0042175,GO:0042470,GO:0042592,GO:0042742,GO:0042886,GO:0043025,GO:0043085,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043473,GO:0043687,GO:0043933,GO:0044085,GO:0044087,GO:0044088,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044267,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044464,GO:0044703,GO:0045184,GO:0045202,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046879,GO:0046883,GO:0046887,GO:0046903,GO:0046907,GO:0047496,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048232,GO:0048285,GO:0048468,GO:0048518,GO:0048522,GO:0048609,GO:0048699,GO:0048731,GO:0048770,GO:0048814,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0050663,GO:0050708,GO:0050714,GO:0050767,GO:0050769,GO:0050773,GO:0050775,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050796,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051270,GO:0051301,GO:0051321,GO:0051338,GO:0051347,GO:0051438,GO:0051443,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0051875,GO:0051904,GO:0051905,GO:0051960,GO:0051962,GO:0060255,GO:0060284,GO:0061024,GO:0061640,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070382,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072384,GO:0072606,GO:0072657,GO:0072741,GO:0080090,GO:0090087,GO:0090110,GO:0090114,GO:0090276,GO:0090277,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098791,GO:0098793,GO:0098805,GO:0098827,GO:0098930,GO:0099111,GO:0099503,GO:0099518,GO:0120035,GO:0140013,GO:1900006,GO:1901265,GO:1901363,GO:1901564,GO:1902115,GO:1903018,GO:1903020,GO:1903046,GO:1903047,GO:1903320,GO:1903322,GO:1903530,GO:1903532,GO:1904666,GO:1904668,GO:1904951,GO:1905037,GO:1905345,GO:1990778,GO:2000026,GO:2000145,GO:2000785 - ko:K07874,ko:K07875 ko05134,map05134 - - - ko00000,ko00001,ko04031,ko04131,ko04147 - - - Ras k59_456098_1 1215092.PA6_020_00240 1.53e-68 223.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1YDM0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_456115_1 1094466.KQS_02640 3.15e-36 127.0 2DN31@1|root,32V8P@2|Bacteria,4NT9U@976|Bacteroidetes,1I4N4@117743|Flavobacteriia,2NWDJ@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_456115_2 1267211.KI669560_gene736 5.59e-34 122.0 COG0663@1|root,COG0663@2|Bacteria,4NG5P@976|Bacteroidetes,1IVF8@117747|Sphingobacteriia 976|Bacteroidetes S Hexapeptide repeat of succinyl-transferase paaY - - ko:K02617,ko:K08279 - - - - ko00000 - - - Hexapep k59_408911_1 232721.Ajs_2196 1.16e-61 199.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2VRG0@28216|Betaproteobacteria,4AD2Z@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_873788_1 313606.M23134_06957 1e-08 58.5 COG3040@1|root,COG3040@2|Bacteria,4NNFA@976|Bacteroidetes,47R64@768503|Cytophagia 976|Bacteroidetes M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_873788_2 595537.Varpa_4134 2.47e-19 86.7 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,4A9P0@80864|Comamonadaceae 28216|Betaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_348509_1 1680.BADO_1246 2.23e-07 55.8 2C08P@1|root,31YSD@2|Bacteria,2I2GB@201174|Actinobacteria,4D1M5@85004|Bifidobacteriales 201174|Actinobacteria S Domain of unknown function (DUF4417) - - - - - - - - - - - - DUF4417 k59_482157_1 1266908.AQPB01000053_gene554 1.62e-74 247.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1WWFC@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_53346_1 1439940.BAY1663_04341 2.64e-66 208.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RRWM@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_456129_1 1158292.JPOE01000005_gene738 4.16e-28 109.0 COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,1NEHF@1224|Proteobacteria,2VNNV@28216|Betaproteobacteria,1KNQR@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Pfam:DUF955 - - - - - - - - - - - - HTH_3,Peptidase_M78 k59_456129_2 1158292.JPOE01000005_gene739 2.63e-113 325.0 COG2405@1|root,COG2405@2|Bacteria,1REYX@1224|Proteobacteria,2W5KZ@28216|Betaproteobacteria,1KP53@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_456129_3 1268622.AVS7_02388 5.09e-57 189.0 COG4924@1|root,COG4924@2|Bacteria,1P11B@1224|Proteobacteria,2VKST@28216|Betaproteobacteria,4AEV6@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria C-term(DUF2220) - - - - - - - - - - - - DUF2220,DUF3322 k59_123955_1 1185876.BN8_03368 8.82e-09 56.2 COG0662@1|root,COG0662@2|Bacteria,4NPM0@976|Bacteroidetes,47Q7D@768503|Cytophagia 976|Bacteroidetes G Cupin domain - - - - - - - - - - - - Cupin_2 k59_764016_1 1041146.ATZB01000032_gene443 1.19e-29 112.0 COG1225@1|root,COG1225@2|Bacteria,1RA5K@1224|Proteobacteria,2U6EF@28211|Alphaproteobacteria 28211|Alphaproteobacteria O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_764016_2 748247.AZKH_0776 1.53e-60 189.0 COG1433@1|root,COG1433@2|Bacteria,1RIKC@1224|Proteobacteria,2VSNY@28216|Betaproteobacteria,2KWKF@206389|Rhodocyclales 206389|Rhodocyclales S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - - k59_205393_1 1198452.Jab_1c20320 4.07e-115 336.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,472GF@75682|Oxalobacteraceae 28216|Betaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_619231_1 1454004.AW11_03721 5.82e-34 135.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1KQ8U@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_16988_1 65393.PCC7424_2738 7.42e-07 56.2 COG0515@1|root,COG1672@1|root,COG3899@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,COG3899@2|Bacteria,1G4QT@1117|Cyanobacteria,3KKPT@43988|Cyanothece 1117|Cyanobacteria KLT Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,AAA_35,GAF,GAF_2,HATPase_c,HisKA,PAS_4,Pkinase k59_456158_1 340.xcc-b100_2818 7.19e-13 68.9 COG0582@1|root,COG0582@2|Bacteria,1QHP9@1224|Proteobacteria,1TFD0@1236|Gammaproteobacteria,1X9BN@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_456158_3 1298867.AUES01000067_gene5135 2.02e-13 65.1 COG3311@1|root,COG3311@2|Bacteria,1NHNR@1224|Proteobacteria,2UM8H@28211|Alphaproteobacteria,3K20Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_979276_1 1437824.BN940_08551 5.78e-21 86.3 COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,2VQ2B@28216|Betaproteobacteria,3T7IJ@506|Alcaligenaceae 28216|Betaproteobacteria S Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_979276_2 395495.Lcho_3637 2.34e-136 390.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,1KKIV@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase ligB - 1.13.11.57,1.13.11.8 ko:K04099,ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA,LigB k59_1055107_1 443152.MDG893_20534 3.21e-11 63.9 2EH64@1|root,33AY0@2|Bacteria,1NKW6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_942280_2 1120999.JONM01000002_gene526 4.96e-08 53.5 COG0742@1|root,COG0742@2|Bacteria,1MX8Z@1224|Proteobacteria,2WGYF@28216|Betaproteobacteria,2KU5A@206351|Neisseriales 206351|Neisseriales J Putative SAM-dependent methyltransferase - - 2.1.1.242 ko:K15984 - - - - ko00000,ko01000,ko03009 - - - SAM_MT k59_1016830_1 1502852.FG94_02300 1.19e-12 67.0 COG0583@1|root,COG0583@2|Bacteria,1NU67@1224|Proteobacteria,2VZMR@28216|Betaproteobacteria,478N8@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1016830_2 1005048.CFU_0658 9.34e-63 199.0 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,478R3@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sigma-70, region 4 rpoE1 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_838722_1 1122951.ATUE01000005_gene1757 1.82e-33 119.0 COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,1S5UP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the frataxin family cyaY GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008199,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016530,GO:0016722,GO:0016724,GO:0018282,GO:0018283,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0033554,GO:0034599,GO:0034986,GO:0036211,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0071840,GO:0098771,GO:0140104,GO:1901564 - ko:K06202 - - - - ko00000 - - iECW_1372.ECW_m4108,iEKO11_1354.EKO11_4552,iWFL_1372.ECW_m4108 Frataxin_Cyay k59_942298_2 1000565.METUNv1_02796 1.08e-61 206.0 COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,2KUQ6@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_909544_2 748247.AZKH_1699 8.62e-83 264.0 COG3598@1|root,COG4643@1|root,COG3598@2|Bacteria,COG4643@2|Bacteria,1R4EA@1224|Proteobacteria,2VKG4@28216|Betaproteobacteria,2KWQR@206389|Rhodocyclales 206389|Rhodocyclales L AAA domain - - - - - - - - - - - - AAA_25,PriCT_2 k59_693925_1 640081.Dsui_0551 6.54e-92 285.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,2KV3F@206389|Rhodocyclales 206389|Rhodocyclales C Nitrogenase component 1 type Oxidoreductase - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_693925_2 136993.KB900626_gene4102 9.09e-11 58.9 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,2U9AX@28211|Alphaproteobacteria,36YQA@31993|Methylocystaceae 28211|Alphaproteobacteria S Dinitrogenase iron-molybdenum cofactor nifX - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_670769_1 614083.AWQR01000014_gene2432 1.53e-80 251.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,4AA1V@80864|Comamonadaceae 28216|Betaproteobacteria S AI-2E family transporter perM - - - - - - - - - - - AI-2E_transport k59_348651_1 399795.CtesDRAFT_PD2093 1.99e-68 216.0 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,2VIQA@28216|Betaproteobacteria,4AAX9@80864|Comamonadaceae 28216|Betaproteobacteria ET extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_482266_1 596154.Alide2_4686 4.98e-115 344.0 COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,4ABE1@80864|Comamonadaceae 28216|Betaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_693944_1 1121481.AUAS01000001_gene4769 2.67e-52 178.0 COG1215@1|root,COG1215@2|Bacteria,4NFI8@976|Bacteroidetes,47PPF@768503|Cytophagia 976|Bacteroidetes M Pfam:DUF2029 - - - - - - - - - - - - GT87 k59_552253_1 1123236.KB899394_gene3154 7.29e-60 207.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria,468ST@72275|Alteromonadaceae 1236|Gammaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_483886_2 1313421.JHBV01000033_gene2372 1.87e-19 86.3 COG1215@1|root,COG1215@2|Bacteria,4NF0S@976|Bacteroidetes,1IRP2@117747|Sphingobacteriia 976|Bacteroidetes M involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_125465_1 716544.wcw_0164 4.38e-38 136.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity ubiE8 - - - - - - - - - - - LicD,Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_765272_1 1175306.GWL_45720 5.62e-115 344.0 COG0789@1|root,COG0789@2|Bacteria,1RCE4@1224|Proteobacteria,2VR0N@28216|Betaproteobacteria,472QB@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_765272_2 987059.RBXJA2T_15003 1.39e-17 80.5 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,1KNEX@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_270044_1 614083.AWQR01000015_gene2494 1.65e-54 175.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,4AC4U@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_270044_2 614083.AWQR01000015_gene2493 1.28e-48 171.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,4A9QW@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_1122780_1 983548.Krodi_0364 1.11e-86 283.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,1HXXA@117743|Flavobacteriia,37DH8@326319|Dokdonia 976|Bacteroidetes K RNA polymerase beta subunit external 1 domain rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_54909_1 331869.BAL199_17178 1.74e-15 73.9 2DNPG@1|root,32YEX@2|Bacteria,1N9QI@1224|Proteobacteria,2UHED@28211|Alphaproteobacteria,4BSN4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1057404_1 1177181.T9A_02291 6.94e-68 228.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria,1RQT4@1236|Gammaproteobacteria,1XNZ0@135619|Oceanospirillales 135619|Oceanospirillales E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_731864_1 3055.DAA00911 5.51e-107 310.0 COG1290@1|root,KOG4663@2759|Eukaryota,37QS7@33090|Viridiplantae,34J8E@3041|Chlorophyta 3041|Chlorophyta C Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions petB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02635 ko00195,ko01100,map00195,map01100 M00162 - - ko00000,ko00001,ko00002,ko00194 - - - Cytochrome_B k59_673149_1 640081.Dsui_2221 1.04e-86 265.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,2KUMJ@206389|Rhodocyclales 206389|Rhodocyclales S AFG1-like ATPase afg - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_1122800_1 1267211.KI669560_gene1326 3.05e-49 159.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,1IT9T@117747|Sphingobacteriia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_458550_1 1121897.AUGO01000002_gene2130 7.69e-22 99.4 COG2274@1|root,COG2274@2|Bacteria,4NFJF@976|Bacteroidetes,1HWYH@117743|Flavobacteriia,2NSS2@237|Flavobacterium 976|Bacteroidetes V ABC transporter ATP-binding protein - - - - - - - - - - - - ABC_membrane,ABC_tran k59_307543_2 1184267.A11Q_1852 2.37e-44 150.0 COG2771@1|root,COG2771@2|Bacteria,1QU5E@1224|Proteobacteria,4319G@68525|delta/epsilon subdivisions,2MT4X@213481|Bdellovibrionales,2WWCU@28221|Deltaproteobacteria 213481|Bdellovibrionales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_483949_1 1000565.METUNv1_02135 9.39e-41 134.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,2VTZ4@28216|Betaproteobacteria,2KWW7@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_243289_1 1265502.KB905933_gene1967 8.47e-62 194.0 COG1132@1|root,COG1132@2|Bacteria,1RDIA@1224|Proteobacteria,2VR6J@28216|Betaproteobacteria,4AE61@80864|Comamonadaceae 28216|Betaproteobacteria V Domain of unknown function (DUF1854) - - - - - - - - - - - - DUF1854 k59_107068_1 748247.AZKH_3544 6.58e-08 53.9 COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,2KUR4@206389|Rhodocyclales 206389|Rhodocyclales K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_107068_2 640081.Dsui_1931 2.23e-63 198.0 COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2VSBM@28216|Betaproteobacteria,2KWF6@206389|Rhodocyclales 206389|Rhodocyclales K overlaps another CDS with the same product name nirG - - - - - - - - - - - HTH_AsnC-type k59_1104487_1 290315.Clim_2254 6.04e-104 306.0 28NCD@1|root,2ZBFF@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - SH3_3 k59_925126_1 1095769.CAHF01000011_gene2281 2.1e-111 330.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,475SF@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_748805_1 351746.Pput_4129 4.25e-11 62.8 COG1484@1|root,COG1484@2|Bacteria,1MZNW@1224|Proteobacteria,1RQFW@1236|Gammaproteobacteria,1YX86@136845|Pseudomonas putida group 1236|Gammaproteobacteria L IstB-like ATP binding protein dnaC - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 k59_819815_1 366649.XFF4834R_chr42170 3.05e-22 100.0 COG2931@1|root,COG3468@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,1T45Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Domains in Na-Ca exchangers and integrin-beta4 - - - - - - - - - - - - Calx-beta k59_243369_1 1437824.BN940_02996 1.53e-117 345.0 COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria 28216|Betaproteobacteria L restriction endonuclease - - - ko:K07448 - - - - ko00000,ko02048 - - - Mrr_N,Mrr_cat k59_243385_1 887062.HGR_07936 7.92e-22 94.4 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,4AAHX@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_748850_1 1353529.M899_0083 1.56e-62 209.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2WIQ9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_34023_1 1502852.FG94_04782 1.77e-74 233.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,476A9@75682|Oxalobacteraceae 28216|Betaproteobacteria E Alanine dehydrogenase/PNT, C-terminal domain ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1104562_1 384765.SIAM614_09803 4.6e-15 75.1 COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TQZR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components MA20_14685 - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1104562_2 391603.FBALC1_00717 1.04e-18 85.9 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,1HXA7@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase zraS_1 - - - - - - - - - - - HATPase_c,HisKA k59_1104588_1 316055.RPE_0335 4.45e-12 66.2 2A5NH@1|root,30UD9@2|Bacteria,1Q6QQ@1224|Proteobacteria,2U4FF@28211|Alphaproteobacteria,3JRZ1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_748885_1 1120999.JONM01000005_gene3850 3.79e-65 213.0 COG1463@1|root,COG1463@2|Bacteria,1PP5N@1224|Proteobacteria,2VV89@28216|Betaproteobacteria,2KT5H@206351|Neisseriales 206351|Neisseriales Q MlaD protein - - - - - - - - - - - - MlaD k59_711028_1 929713.NIASO_11055 9.97e-125 359.0 COG1246@1|root,COG1246@2|Bacteria,4NGXY@976|Bacteroidetes,1J0ZE@117747|Sphingobacteriia 976|Bacteroidetes E Acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_70434_1 748280.NH8B_2378 2.19e-77 240.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type II secretion system tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_1139216_1 1463841.JOIR01000018_gene1027 4.56e-14 77.0 COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria 201174|Actinobacteria I Belongs to the type-B carboxylesterase lipase family - - - - - - - - - - - - COesterase k59_925204_1 580332.Slit_0111 2.71e-11 63.9 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,44VWM@713636|Nitrosomonadales 28216|Betaproteobacteria NU Pilus assembly protein, PilP pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_925204_2 365044.Pnap_0674 2.05e-34 125.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,4AANW@80864|Comamonadaceae 28216|Betaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_996464_1 365046.Rta_19580 3.93e-116 345.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,4AA39@80864|Comamonadaceae 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_322241_2 1000565.METUNv1_02096 1.17e-174 494.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2VJ3C@28216|Betaproteobacteria,2KVXZ@206389|Rhodocyclales 206389|Rhodocyclales O protein required for cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_853_1 1000565.METUNv1_01028 1.48e-95 287.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,2KUUI@206389|Rhodocyclales 206389|Rhodocyclales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine sua5 - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_750171_1 700598.Niako_2569 3.74e-52 179.0 COG1538@1|root,COG1538@2|Bacteria,4NEMI@976|Bacteroidetes,1INTW@117747|Sphingobacteriia 976|Bacteroidetes MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_607203_1 1000565.METUNv1_03377 2.57e-144 409.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,2KUUC@206389|Rhodocyclales 206389|Rhodocyclales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_607203_2 1000565.METUNv1_03378 1.13e-86 256.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,2KWB0@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_643527_1 1283077.M1HLI2_9CAUD 1.7e-56 207.0 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_821631_1 1244869.H261_12401 2.89e-52 176.0 COG1410@1|root,COG1410@2|Bacteria,1NSVT@1224|Proteobacteria 1224|Proteobacteria E Pterin binding enzyme - - - - - - - - - - - - Pterin_bind k59_821631_2 760568.Desku_2708 2.22e-09 59.3 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae 186801|Clostridia C PFAM 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - DUF4445,Fer2 k59_535986_1 1348657.M622_12570 3.81e-154 461.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,2KV9I@206389|Rhodocyclales 206389|Rhodocyclales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1071834_1 1000565.METUNv1_02805 4.77e-20 81.6 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,2KX9K@206389|Rhodocyclales 206389|Rhodocyclales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1071834_2 1000565.METUNv1_02806 5e-98 285.0 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,2KW54@206389|Rhodocyclales 206389|Rhodocyclales H Molybdopterin converting factor, large subunit moaE - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_1000105_1 644801.Psest_4045 1.11e-123 364.0 COG2865@1|root,COG2865@2|Bacteria,1MXG1@1224|Proteobacteria,1S9M1@1236|Gammaproteobacteria,1Z3NQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Putative DNA-binding domain - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AlbA_2,HATPase_c_4 k59_322258_1 614083.AWQR01000025_gene3751 3.04e-89 269.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VNMX@28216|Betaproteobacteria,4AAMC@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase pldB - 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_786125_1 1323663.AROI01000009_gene3648 2.38e-101 313.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_643541_2 1000565.METUNv1_03845 8.91e-169 482.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,2KW9U@206389|Rhodocyclales 206389|Rhodocyclales H HemX, putative uroporphyrinogen-III C-methyltransferase hemX - 2.1.1.107 ko:K02496 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - HemX k59_643541_3 1000565.METUNv1_03844 8.24e-114 335.0 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,2KVD0@206389|Rhodocyclales 206389|Rhodocyclales H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_643541_4 1000565.METUNv1_03843 1.82e-137 396.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,2KVQ9@206389|Rhodocyclales 206389|Rhodocyclales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_821646_1 748247.AZKH_3545 1.98e-103 310.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,2KVXA@206389|Rhodocyclales 206389|Rhodocyclales S cytochrome d1 heme nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_214781_1 1000565.METUNv1_02380 7.92e-150 423.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,2KVV2@206389|Rhodocyclales 206389|Rhodocyclales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_72010_1 1000565.METUNv1_03465 1.85e-105 308.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,2KUMH@206389|Rhodocyclales 206389|Rhodocyclales O protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1000124_1 1005048.CFU_3767 9.72e-88 271.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,472KR@75682|Oxalobacteraceae 28216|Betaproteobacteria P Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_322293_1 106648.BBLJ01000047_gene3744 2.17e-52 182.0 COG3185@1|root,COG3185@2|Bacteria,1MVR0@1224|Proteobacteria,1RR9Q@1236|Gammaproteobacteria,3NM7A@468|Moraxellaceae 1236|Gammaproteobacteria E Pfam:DUF1446 atuA - - - - - - - - - - - AtuA k59_107736_1 94122.Shewana3_0582 7.61e-14 76.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2QAC7@267890|Shewanellaceae 1236|Gammaproteobacteria T PFAM chemotaxis sensory transducer - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_821658_1 376686.Fjoh_1374 1.91e-16 76.6 COG1878@1|root,COG1878@2|Bacteria,4NFXM@976|Bacteroidetes,1HWQP@117743|Flavobacteriia,2NSD1@237|Flavobacterium 976|Bacteroidetes S Metal-dependent hydrolase - - - - - - - - - - - - Cyclase k59_821658_2 945713.IALB_0322 1.46e-42 154.0 COG0821@1|root,COG0821@2|Bacteria 2|Bacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iHN637.CLJU_RS06430,iIT341.HP0625,iJN678.gcpE,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037 GcpE k59_714734_1 1134474.O59_000169 2.9e-119 353.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1FFV5@10|Cellvibrio 1236|Gammaproteobacteria H S-adenosyl-L-homocysteine hydrolase, NAD binding domain ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - iYL1228.KPN_02462 AdoHcyase,AdoHcyase_NAD k59_1107205_1 683837.lse_1470 1.86e-05 51.6 COG1587@1|root,COG1587@2|Bacteria,1VF07@1239|Firmicutes,4HPUZ@91061|Bacilli,26J5X@186820|Listeriaceae 91061|Bacilli H Uroporphyrinogen-III synthase hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_214792_1 1000565.METUNv1_01390 3.93e-70 224.0 COG3851@1|root,COG3851@2|Bacteria,1QUAD@1224|Proteobacteria,2WHPU@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3 k59_214792_2 1000565.METUNv1_01389 2.81e-18 82.0 COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria,2KUG5@206389|Rhodocyclales 206389|Rhodocyclales I Alpha/beta hydrolase family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_322301_1 1122951.ATUE01000006_gene1136 6.22e-119 346.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,3NKV6@468|Moraxellaceae 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_322301_2 1122951.ATUE01000006_gene1137 1.38e-13 69.7 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,3NJ1X@468|Moraxellaceae 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_179509_1 1000565.METUNv1_01331 2.39e-67 218.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2VH2B@28216|Betaproteobacteria,2KVS2@206389|Rhodocyclales 206389|Rhodocyclales V extrusion protein MatE norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_179509_2 1000565.METUNv1_01330 4.05e-189 530.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,2KVCI@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_607227_1 1000565.METUNv1_00993 1.61e-83 278.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_500786_3 666681.M301_2725 2.15e-19 89.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,2KKK9@206350|Nitrosomonadales 206350|Nitrosomonadales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_143531_1 1317122.ATO12_00705 2.5e-35 134.0 COG1020@1|root,COG1020@2|Bacteria,4NGU4@976|Bacteroidetes,1I04Z@117743|Flavobacteriia,2YHGT@290174|Aquimarina 976|Bacteroidetes Q AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_464835_1 105559.Nwat_3050 6.72e-45 167.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_72030_1 1123355.JHYO01000006_gene2278 7.2e-21 90.5 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,36Y7H@31993|Methylocystaceae 28211|Alphaproteobacteria M Lytic transglycolase rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_500804_1 697282.Mettu_3590 3.41e-51 175.0 COG2206@1|root,COG2206@2|Bacteria,1R53C@1224|Proteobacteria,1RZQD@1236|Gammaproteobacteria,1XG32@135618|Methylococcales 135618|Methylococcales T PFAM Metal-dependent phosphohydrolase, HD region, subdomain - - - - - - - - - - - - HD k59_750219_1 75379.Tint_3218 3.03e-85 259.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,1KPGY@119065|unclassified Burkholderiales 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_3 k59_143535_1 1000565.METUNv1_02586 8.95e-106 309.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,2KVMH@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_143535_2 1000565.METUNv1_02585 5.43e-70 213.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,2KWM4@206389|Rhodocyclales 206389|Rhodocyclales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_393512_1 1000565.METUNv1_02011 1.92e-41 152.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,2KV14@206389|Rhodocyclales 206389|Rhodocyclales M Membrane-bound lytic murein transglycosylase mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_107754_1 1000565.METUNv1_00140 1.37e-184 524.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,2KU87@206389|Rhodocyclales 206389|Rhodocyclales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_107754_2 1000565.METUNv1_00139 2.16e-156 446.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,2KUH4@206389|Rhodocyclales 206389|Rhodocyclales D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_36510_1 1121896.JMLU01000041_gene551 2.58e-05 43.9 2EGD6@1|root,33A4Z@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_36510_2 1000565.METUNv1_03871 1.45e-148 422.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,2KUK6@206389|Rhodocyclales 206389|Rhodocyclales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_643602_1 1408813.AYMG01000009_gene3144 9.4e-95 280.0 COG2057@1|root,COG2057@2|Bacteria,4NG9J@976|Bacteroidetes,1IQBC@117747|Sphingobacteriia 976|Bacteroidetes I PFAM Coenzyme A transferase scoB - 2.8.3.5,2.8.3.6 ko:K01029,ko:K01032 ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120 - R00410,R02990 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_607243_1 1417296.U879_08500 8.24e-71 223.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_607243_2 545276.KB898732_gene2401 1.7e-09 57.8 COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1WW64@135613|Chromatiales 135613|Chromatiales M Belongs to the mannose-6-phosphate isomerase type 2 family - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_429386_1 1000565.METUNv1_02026 6.53e-220 634.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_464849_1 1000565.METUNv1_02617 6.39e-67 224.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria,2KVKM@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_464849_2 395494.Galf_1027 1.75e-22 90.9 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,2VWS3@28216|Betaproteobacteria,44WKJ@713636|Nitrosomonadales 28216|Betaproteobacteria T STAS domain - - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS_2 k59_464849_3 1000565.METUNv1_02614 4.16e-105 313.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,2KUJP@206389|Rhodocyclales 206389|Rhodocyclales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1107239_1 1123487.KB892866_gene1745 1.61e-75 235.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,2KV5M@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,Response_reg k59_286414_1 1123354.AUDR01000013_gene488 2.8e-120 350.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VJ2H@28216|Betaproteobacteria 28216|Betaproteobacteria Q taurine catabolism dioxygenase - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_714786_2 76114.ebA5991 2.39e-68 214.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,2KV64@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_928556_2 107636.JQNK01000009_gene2405 1.49e-49 162.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2U6GH@28211|Alphaproteobacteria,3707E@31993|Methylocystaceae 28211|Alphaproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_928556_3 987059.RBXJA2T_11473 4.25e-103 302.0 297UU@1|root,2ZV1D@2|Bacteria,1MXFE@1224|Proteobacteria,2VIEE@28216|Betaproteobacteria,1KJPW@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_36533_1 1454004.AW11_03639 1.93e-76 251.0 COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,2VN4Y@28216|Betaproteobacteria 28216|Betaproteobacteria L RecF RecN SMC N terminal domain-containing protein - - - - - - - - - - - - AAA_23,AAA_27 k59_655342_1 159450.NH14_26715 7.1e-29 115.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2VII5@28216|Betaproteobacteria,1K35E@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_756122_1 1144319.PMI16_01035 1.03e-74 226.0 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,2VRJ4@28216|Betaproteobacteria,4743W@75682|Oxalobacteraceae 28216|Betaproteobacteria G Peptidyl-prolyl cis-trans fkpB - 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_970292_1 1000565.METUNv1_00906 3.82e-55 178.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KVC2@206389|Rhodocyclales 206389|Rhodocyclales L Hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_970292_3 1000565.METUNv1_00904 1.5e-168 479.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,2KUK8@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_472232_1 13735.ENSPSIP00000020169 2.32e-28 108.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,48B0V@7711|Chordata,499U9@7742|Vertebrata,4CK8P@8459|Testudines 33208|Metazoa L K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,rve,zf-CCHC,zf-H2C2 k59_190822_2 596153.Alide_0683 1.26e-46 164.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,4AAVU@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_863750_1 1198452.Jab_2c21200 3.15e-107 316.0 COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,2VKEP@28216|Betaproteobacteria,473FG@75682|Oxalobacteraceae 28216|Betaproteobacteria G xylanase chitin deacetylase arnD - - - - - - - - - - - Polysacc_deac_1 k59_901430_1 1472716.KBK24_0104265 4.21e-48 160.0 COG0500@1|root,COG0500@2|Bacteria,1MWPI@1224|Proteobacteria,2VQG5@28216|Betaproteobacteria,1K4TK@119060|Burkholderiaceae 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_114430_1 1268622.AVS7_03796 2.7e-135 391.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,4A9JU@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_114430_2 398578.Daci_5431 4.29e-19 83.2 COG3017@1|root,COG3017@2|Bacteria,1N2F2@1224|Proteobacteria,2VUJH@28216|Betaproteobacteria,4AF6I@80864|Comamonadaceae 28216|Betaproteobacteria M Outer membrane lipoprotein lolB - - ko:K02494 - - - - ko00000 - - - LolB k59_190829_1 365044.Pnap_4588 3.13e-93 305.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE k59_1043311_1 1000565.METUNv1_03858 1.94e-236 657.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,2KUHQ@206389|Rhodocyclales 206389|Rhodocyclales E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_512167_2 1123257.AUFV01000007_gene281 2.51e-35 129.0 COG1309@1|root,COG1309@2|Bacteria,1MUJ5@1224|Proteobacteria,1RN9W@1236|Gammaproteobacteria,1X3N6@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional regulator fabR - - ko:K22105 - - - - ko00000,ko03000 - - - TetR_N k59_333513_1 580332.Slit_0443 1.2e-24 99.8 COG2165@1|root,COG2165@2|Bacteria,1REMT@1224|Proteobacteria,2VR8U@28216|Betaproteobacteria,44W0Y@713636|Nitrosomonadales 28216|Betaproteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_333513_2 760192.Halhy_1613 0.000349 44.7 COG0745@1|root,COG3852@1|root,COG0745@2|Bacteria,COG3852@2|Bacteria,4PN2Z@976|Bacteroidetes,1J0WK@117747|Sphingobacteriia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_756136_1 497321.C664_12975 2.82e-61 202.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,2KUT0@206389|Rhodocyclales 206389|Rhodocyclales M 3-Deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_1083748_1 95619.PM1_0200995 1.52e-30 112.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_1083748_2 768671.ThimaDRAFT_3347 3.17e-38 139.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_901438_1 1348657.M622_03660 9.64e-31 110.0 COG4390@1|root,COG4390@2|Bacteria,1N8RK@1224|Proteobacteria,2VUJW@28216|Betaproteobacteria,2KWNK@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - - - - - - - - - - DUF2322 k59_901438_2 1000565.METUNv1_00168 2.44e-60 198.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KUAY@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_577606_1 1000565.METUNv1_00378 4.9e-47 155.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,2VVP0@28216|Betaproteobacteria,2KXBI@206389|Rhodocyclales 206389|Rhodocyclales J RNA-binding protein containing KH domain possibly ribosomal protein - - - - - - - - - - - - CRS1_YhbY k59_577606_2 1000565.METUNv1_00377 8.79e-98 286.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,2KUSV@206389|Rhodocyclales 206389|Rhodocyclales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_190842_1 1124982.MSI_22640 4.12e-15 72.8 COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes 203691|Spirochaetes L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1083754_1 614083.AWQR01000009_gene537 1.71e-102 311.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VHRA@28216|Betaproteobacteria,4A9T3@80864|Comamonadaceae 28216|Betaproteobacteria P ABC transporter gguA - 3.6.3.17 ko:K10548 ko02010,map02010 M00216 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.5 - - ABC_tran k59_793931_1 1123255.JHYS01000010_gene447 3.02e-97 299.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2VJ02@28216|Betaproteobacteria,4AEDN@80864|Comamonadaceae 28216|Betaproteobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_655389_1 1276756.AUEX01000005_gene2706 9.99e-140 414.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,4AB6C@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_756146_1 977880.RALTA_B0675 3.55e-48 173.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,1K0YQ@119060|Burkholderiaceae 28216|Betaproteobacteria KQ PFAM sigma-54 factor interaction domain-containing protein - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_970324_1 365046.Rta_36950 9.29e-05 50.4 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,4AC9D@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_829882_1 1000565.METUNv1_03805 1.5e-93 291.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_829882_2 1000565.METUNv1_03806 3.25e-77 236.0 COG3017@1|root,COG3017@2|Bacteria,1N5H9@1224|Proteobacteria,2VUJP@28216|Betaproteobacteria,2KX7X@206389|Rhodocyclales 206389|Rhodocyclales M Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein lolB - - ko:K02494 - - - - ko00000 - - - LolB k59_114458_1 1123073.KB899241_gene2493 1.06e-160 471.0 COG0330@1|root,COG0330@2|Bacteria,1MW1D@1224|Proteobacteria,1SN0S@1236|Gammaproteobacteria,1X5JY@135614|Xanthomonadales 135614|Xanthomonadales O SPFH domain / Band 7 family - - - - - - - - - - - - Band_7 k59_863790_1 1000565.METUNv1_02420 1.61e-89 270.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,2KW45@206389|Rhodocyclales 206389|Rhodocyclales M VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_577624_1 1000565.METUNv1_02412 2.72e-100 307.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUQA@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1112959_1 1005048.CFU_3018 7.5e-88 264.0 COG3279@1|root,COG3279@2|Bacteria,1R9Q4@1224|Proteobacteria,2WEES@28216|Betaproteobacteria,473Y1@75682|Oxalobacteraceae 28216|Betaproteobacteria KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_655423_1 1382230.ASAP_2763 2.93e-15 73.9 2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_333564_1 1000565.METUNv1_02377 1.81e-59 201.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2WGQE@28216|Betaproteobacteria,2KUAH@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9 k59_333564_2 1000565.METUNv1_02378 1.3e-51 163.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,2KWXA@206389|Rhodocyclales 206389|Rhodocyclales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_795125_1 331869.BAL199_13068 7.02e-19 88.2 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_685854_1 1454004.AW11_02348 2.74e-73 243.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1KPNC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_259644_1 1122951.ATUE01000006_gene866 2.15e-75 246.0 28J7E@1|root,2Z92U@2|Bacteria,1NAE1@1224|Proteobacteria,1RRQ0@1236|Gammaproteobacteria,3NIGH@468|Moraxellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_513994_1 1328313.DS2_05580 4.49e-38 145.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,463YC@72275|Alteromonadaceae 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_795136_2 1000565.METUNv1_03778 6.39e-12 65.5 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KYI9@206389|Rhodocyclales 206389|Rhodocyclales M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_151269_1 342113.DM82_5063 5.18e-57 182.0 COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2VQ1J@28216|Betaproteobacteria,1K50F@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH dehydrogenase NAD(P)H nitroreductase rutE - - ko:K09019 ko00240,ko01100,map00240,map01100 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Nitroreductase k59_220573_1 765912.Thimo_0486 1.16e-47 171.0 COG1289@1|root,COG1289@2|Bacteria,1MX9H@1224|Proteobacteria,1RSD7@1236|Gammaproteobacteria,1WXR6@135613|Chromatiales 135613|Chromatiales S Fusaric acid resistance protein - - - - - - - - - - - - FUSC k59_902659_1 398527.Bphyt_0041 2.18e-59 199.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VKAQ@28216|Betaproteobacteria,1KFGH@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the amidase family - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_8808_1 62928.azo0004 1.06e-93 291.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VK6V@28216|Betaproteobacteria,2KYFC@206389|Rhodocyclales 206389|Rhodocyclales L HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_335327_1 477228.YO5_18782 2.39e-85 258.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1Z2D8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_473434_1 1000565.METUNv1_02705 2.48e-84 275.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVF1@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_722504_1 441768.ACL_0341 0.000228 45.1 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_543272_1 519989.ECTPHS_01354 2.55e-55 178.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales 135613|Chromatiales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_543272_2 349521.HCH_01355 1.35e-30 110.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XM21@135619|Oceanospirillales 135619|Oceanospirillales O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_971295_1 688245.CtCNB1_2075 1.31e-51 172.0 COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,4AAQM@80864|Comamonadaceae 28216|Betaproteobacteria P Sulfate ABC transporter, inner membrane subunit CysW cysW - - ko:K02047 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - BPD_transp_1 k59_1113893_1 365044.Pnap_1634 7.04e-59 201.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,4AAY1@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_657348_1 1121904.ARBP01000015_gene205 4.41e-31 124.0 COG4166@1|root,COG4166@2|Bacteria,4NFT5@976|Bacteroidetes,47NYD@768503|Cytophagia 976|Bacteroidetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_473441_1 1000565.METUNv1_03265 5.5e-115 336.0 COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2VJR1@28216|Betaproteobacteria,2KW7X@206389|Rhodocyclales 206389|Rhodocyclales H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_864964_1 1123393.KB891330_gene803 2.82e-64 213.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,1KRZZ@119069|Hydrogenophilales 119069|Hydrogenophilales M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_80652_1 669262.COK_2295 2.26e-27 111.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1Y7RE@135625|Pasteurellales 135625|Pasteurellales C fumarate reductase, flavoprotein subunit frdA GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_80652_2 1279038.KB907337_gene210 7.45e-115 336.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2U3AH@28211|Alphaproteobacteria,2JRIM@204441|Rhodospirillales 204441|Rhodospirillales C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_3,Fer4_8 k59_971305_1 640081.Dsui_1554 1.16e-47 171.0 COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_971305_2 28229.ND2E_4175 4.13e-45 164.0 COG2203@1|root,COG3221@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3221@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_335374_1 1198452.Jab_1c17390 1.04e-88 274.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,472U1@75682|Oxalobacteraceae 28216|Betaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_971315_1 1448139.AI20_11915 3.65e-90 281.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1RPS2@1236|Gammaproteobacteria,1Y5C9@135624|Aeromonadales 135624|Aeromonadales V Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_971319_2 1000565.METUNv1_03478 2.46e-13 67.8 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,2KUZ9@206389|Rhodocyclales 206389|Rhodocyclales E 5,10-methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1113918_1 1223521.BBJX01000002_gene2827 3.11e-177 511.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1MVWM@1224|Proteobacteria,2VK4W@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - - - - - - - - - - GGDEF,Response_reg k59_259713_1 1000565.METUNv1_01946 3.15e-203 568.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,2KVNM@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the dGTPase family. Type 2 subfamily dgt1 - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_259713_2 1000565.METUNv1_01945 6.86e-126 367.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KURZ@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_80675_1 1000565.METUNv1_02285 1.21e-179 508.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,2KVBF@206389|Rhodocyclales 206389|Rhodocyclales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_220626_1 29486.NJ56_13370 4.12e-33 128.0 COG3405@1|root,COG3405@2|Bacteria,1MW17@1224|Proteobacteria,1RNEU@1236|Gammaproteobacteria,41D9C@629|Yersinia 1236|Gammaproteobacteria G Glycosyl hydrolases family 8 bcsZ GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0008810,GO:0016787,GO:0016798 3.2.1.4 ko:K20542 - - - - ko00000,ko01000 - GH8 - Glyco_hydro_8 k59_685919_1 338969.Rfer_3746 2.42e-118 345.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2VK37@28216|Betaproteobacteria,4AAFN@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Creatininase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_402256_2 1229909.NSED_07760 2.02e-12 62.0 arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_443128_2 1000565.METUNv1_00848 2.36e-13 68.9 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,2KUX1@206389|Rhodocyclales 206389|Rhodocyclales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_795212_1 4577.GRMZM5G804358_P02 7.44e-92 285.0 COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GJ6Q@35493|Streptophyta,3KPUK@4447|Liliopsida,3ICWT@38820|Poales 35493|Streptophyta C Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) nad4 - - - - - - - - - - - Proton_antipo_M k59_578573_1 748247.AZKH_p0611 1.8e-76 236.0 COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2VK8R@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the 3-hydroxyisobutyrate dehydrogenase family - - 1.1.1.411 ko:K08319 - - - - ko00000,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1044209_1 1121897.AUGO01000007_gene485 2.52e-51 165.0 298UU@1|root,2ZVYZ@2|Bacteria,4NPH1@976|Bacteroidetes,1I8RV@117743|Flavobacteriia,2NWGH@237|Flavobacterium 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_384022_1 1000565.METUNv1_00446 8.84e-63 206.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VJRK@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1,Glu_cyclase_2,Lactonase k59_590167_1 1123248.KB893319_gene4038 6.67e-103 304.0 COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes,1IQSP@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_845599_1 1000565.METUNv1_00673 4.5e-51 170.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,2KVDU@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 transport system, periplasmic component - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_845599_2 1123514.KB905899_gene1992 2.08e-05 45.1 COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,1SDBW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S effector of murein hydrolase LrgA - - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA k59_22843_1 1380394.JADL01000001_gene2376 1.56e-13 75.5 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1QTVB@1224|Proteobacteria,2TW7E@28211|Alphaproteobacteria,2JZ2B@204441|Rhodospirillales 204441|Rhodospirillales T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg k59_845603_1 1095769.CAHF01000022_gene54 8.97e-61 192.0 COG1802@1|root,COG1802@2|Bacteria,1R90Y@1224|Proteobacteria,2VKEN@28216|Betaproteobacteria,472FA@75682|Oxalobacteraceae 28216|Betaproteobacteria K PFAM Bacterial regulatory proteins, gntR family, FCD domain gntR3 - - - - - - - - - - - FCD,GntR k59_845603_2 1121441.AUCX01000024_gene1752 1.16e-47 166.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42UBK@68525|delta/epsilon subdivisions,2WQU5@28221|Deltaproteobacteria,2MGYF@213115|Desulfovibrionales 28221|Deltaproteobacteria T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD,HD_5 k59_1126970_1 614083.AWQR01000022_gene116 1.86e-79 245.0 COG4286@1|root,COG4286@2|Bacteria,1MVTY@1224|Proteobacteria,2W2U2@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterised protein family (UPF0160) - - - - - - - - - - - - UPF0160 k59_232574_1 1000565.METUNv1_00452 4.5e-145 426.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KY7E@206389|Rhodocyclales 206389|Rhodocyclales K GAF domain - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_489149_1 1121035.AUCH01000012_gene2998 7.12e-84 259.0 COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,2VHZ6@28216|Betaproteobacteria,2KV85@206389|Rhodocyclales 206389|Rhodocyclales E Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_414245_1 1121035.AUCH01000020_gene2638 8.43e-30 121.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,2KVEA@206389|Rhodocyclales 206389|Rhodocyclales O Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_16,TPR_19,TPR_8 k59_1064293_1 272943.RSP_2882 2.72e-09 63.2 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,1FBXW@1060|Rhodobacter 28211|Alphaproteobacteria K Two component transcriptional regulator, LuxR family - - - - - - - - - - - - GerE,Response_reg k59_22877_1 1230342.CTM_10938 1.1e-17 88.6 COG0249@1|root,COG0249@2|Bacteria,1TPJP@1239|Firmicutes,247IW@186801|Clostridia,36DYT@31979|Clostridiaceae 186801|Clostridia L DNA mismatch repair protein MutS mutS4 - - - - - - - - - - - MutS_III,MutS_V k59_809612_1 614083.AWQR01000007_gene388 8.31e-33 121.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,4AD3Y@80864|Comamonadaceae 28216|Betaproteobacteria T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_809612_2 1123255.JHYS01000002_gene2699 3.39e-42 145.0 COG0500@1|root,COG0500@2|Bacteria,1QVCU@1224|Proteobacteria,2VP24@28216|Betaproteobacteria,4AB80@80864|Comamonadaceae 28216|Betaproteobacteria Q methyltransferase - - - - - - - - - - - - - k59_489191_1 614083.AWQR01000045_gene2039 1.51e-40 149.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,4A9NR@80864|Comamonadaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_947303_1 1120999.JONM01000001_gene1305 1.06e-50 179.0 COG3511@1|root,COG3511@2|Bacteria,1R78F@1224|Proteobacteria,2VXFB@28216|Betaproteobacteria 28216|Betaproteobacteria M Phosphoesterase family - - - - - - - - - - - - Phosphoesterase k59_414271_2 55529.EKX47288 7.86e-21 94.4 COG0144@1|root,KOG1122@2759|Eukaryota 2759|Eukaryota J rRNA (cytosine-C5-)-methyltransferase activity - GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_914794_1 1000565.METUNv1_02166 5.39e-98 301.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,2KU8A@206389|Rhodocyclales 206389|Rhodocyclales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_313183_1 1000565.METUNv1_02544 7.05e-91 278.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,2KUND@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_489222_1 614083.AWQR01000018_gene1776 6.9e-142 413.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,4AA30@80864|Comamonadaceae 28216|Betaproteobacteria J ribonuclease, Rne Rng family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_232628_1 504487.JCM19302_1711 2.29e-68 217.0 COG1215@1|root,COG1215@2|Bacteria,4NEG0@976|Bacteroidetes,1HXHU@117743|Flavobacteriia 976|Bacteroidetes M glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_59237_2 1217718.ALOU01000002_gene4640 2.3e-99 290.0 COG0175@1|root,COG0175@2|Bacteria,1R52W@1224|Proteobacteria,2VKQC@28216|Betaproteobacteria,1K96Z@119060|Burkholderiaceae 28216|Betaproteobacteria EH Phosphoadenosine phosphosulfate reductase - - - - - - - - - - - - PAPS_reduct k59_590250_1 358220.C380_14765 8.38e-61 202.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VGZY@28216|Betaproteobacteria,4AAS5@80864|Comamonadaceae 28216|Betaproteobacteria K aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2,GntR k59_769081_1 667632.KB890181_gene849 4.45e-72 253.0 COG3736@1|root,COG3736@2|Bacteria,1PDFE@1224|Proteobacteria,2WB1R@28216|Betaproteobacteria,1K4XM@119060|Burkholderiaceae 28216|Betaproteobacteria U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase k59_769081_3 1218084.BBJK01000041_gene3707 7.48e-06 51.2 2AH0P@1|root,3179J@2|Bacteria,1PYJB@1224|Proteobacteria,2WDRE@28216|Betaproteobacteria,1KAV2@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_769081_4 1123392.AQWL01000013_gene2419 2.54e-108 317.0 2CJX8@1|root,2ZAA9@2|Bacteria,1RFA5@1224|Proteobacteria,2VS1G@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_880132_1 640511.BC1002_5470 1.35e-61 196.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,1K4XA@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM LemA family protein lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_590267_2 614083.AWQR01000013_gene1669 1.79e-60 196.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2VHX0@28216|Betaproteobacteria,4A9ZN@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_880142_1 338969.Rfer_0659 4.69e-85 266.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria,4ADEV@80864|Comamonadaceae 28216|Betaproteobacteria M G-rich domain on putative tyrosine kinase - - - - - - - - - - - - GNVR,Wzz k59_1064402_1 1380394.JADL01000016_gene401 2.04e-71 240.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JQ03@204441|Rhodospirillales 204441|Rhodospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_769108_1 644801.Psest_4044 1.6e-82 269.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1Z17A@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_769108_2 644801.Psest_4045 5.08e-40 143.0 COG2865@1|root,COG2865@2|Bacteria,1MXG1@1224|Proteobacteria,1S9M1@1236|Gammaproteobacteria,1Z3NQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Putative DNA-binding domain - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AlbA_2,HATPase_c_4 k59_985060_1 338969.Rfer_3308 7.94e-75 243.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,4A9M7@80864|Comamonadaceae 28216|Betaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_880165_1 1201290.M902_1276 8.38e-55 186.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2MSS3@213481|Bdellovibrionales,2WJUK@28221|Deltaproteobacteria 213481|Bdellovibrionales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_232680_1 666681.M301_2457 5.34e-69 221.0 COG0477@1|root,COG0477@2|Bacteria,1QUAG@1224|Proteobacteria,2WHA4@28216|Betaproteobacteria,2KKM8@206350|Nitrosomonadales 206350|Nitrosomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_414342_2 644801.Psest_4045 2.06e-62 203.0 COG2865@1|root,COG2865@2|Bacteria,1MXG1@1224|Proteobacteria,1S9M1@1236|Gammaproteobacteria,1Z3NQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Putative DNA-binding domain - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AlbA_2,HATPase_c_4 k59_214065_1 62928.azo2482 4.64e-87 293.0 COG0642@1|root,COG3829@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_880203_2 365046.Rta_01860 6.14e-28 104.0 2ASHY@1|root,31HYC@2|Bacteria,1RIM4@1224|Proteobacteria,2VSD6@28216|Betaproteobacteria,4AEK4@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_59328_1 1000565.METUNv1_03298 3.18e-68 228.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1064509_1 391735.Veis_1671 2.77e-73 230.0 COG2199@1|root,COG3706@2|Bacteria,1R6GI@1224|Proteobacteria,2VM5N@28216|Betaproteobacteria,4A9XC@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_59337_1 1265502.KB905941_gene2905 2.35e-51 184.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,4ABCW@80864|Comamonadaceae 28216|Betaproteobacteria T ATP-binding region, ATPase domain protein pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_623649_1 595536.ADVE02000001_gene1026 1.27e-47 167.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TU35@28211|Alphaproteobacteria,36Y7U@31993|Methylocystaceae 28211|Alphaproteobacteria P Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_987390_1 1346791.M529_10280 8.71e-34 134.0 COG0369@1|root,COG3182@1|root,COG0369@2|Bacteria,COG3182@2|Bacteria,1MWYV@1224|Proteobacteria,2TW5P@28211|Alphaproteobacteria,2K3CY@204457|Sphingomonadales 204457|Sphingomonadales P Flavodoxin - - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_1,NAD_binding_1,PepSY_TM k59_234542_1 62928.azo2964 5.02e-72 226.0 COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VKAX@28216|Betaproteobacteria,2KVSI@206389|Rhodocyclales 206389|Rhodocyclales S Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist k59_625360_1 1163617.SCD_n00622 8.39e-131 391.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1026054_1 395964.KE386496_gene223 1.48e-66 219.0 COG3182@1|root,COG3182@2|Bacteria,1MUX8@1224|Proteobacteria,2TVQ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_168419_1 1122951.ATUE01000007_gene814 1.08e-05 47.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,3NJA8@468|Moraxellaceae 1236|Gammaproteobacteria O Glycoprotease family yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_168419_2 1415780.JPOG01000001_gene1361 1.42e-27 105.0 COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,1SAHQ@1236|Gammaproteobacteria,1X6ZN@135614|Xanthomonadales 135614|Xanthomonadales S Acyl-ACP thioesterase - - - - - - - - - - - - 4HBT_2,Acyl-ACP_TE k59_234552_1 1122951.ATUE01000005_gene1612 8.4e-95 301.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,3NJYW@468|Moraxellaceae 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_625366_1 197221.22294696 6.52e-05 52.8 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - - ko:K10297 - - - - ko00000,ko04121 - - - Beta_helix,NosD,Pectinesterase,Pkinase,SH3_3 k59_25137_1 1210884.HG799466_gene12567 8.83e-26 111.0 COG0526@1|root,COG0526@2|Bacteria,2IWVQ@203682|Planctomycetes 203682|Planctomycetes CO PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain - - - - - - - - - - - - AhpC-TSA,Cu2_monoox_C k59_387577_1 1454004.AW11_02899 3.27e-59 204.0 COG0699@1|root,COG1396@1|root,COG0699@2|Bacteria,COG1396@2|Bacteria,1R3H5@1224|Proteobacteria,2W19D@28216|Betaproteobacteria 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_491954_1 931627.MycrhDRAFT_2420 1.75e-07 59.7 COG2730@1|root,COG2730@2|Bacteria,2I2VY@201174|Actinobacteria,23FHM@1762|Mycobacteriaceae 201174|Actinobacteria G Calx-beta domain celA - 3.2.1.4 ko:K01179,ko:K20628 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,Cellulase,fn3 k59_949335_1 1040989.AWZU01000020_gene2010 3.71e-08 58.2 COG5485@1|root,COG5485@2|Bacteria,1NG9D@1224|Proteobacteria,2UKJ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_61430_1 159087.Daro_1047 3.88e-97 288.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,2KUDT@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases fnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1097542_1 365046.Rta_01600 1.35e-102 309.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,4A9Z8@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily lplT - - - - - - - - - - - MFS_1 k59_1067842_2 557598.LHK_00100 5.76e-42 142.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,2KQZV@206351|Neisseriales 206351|Neisseriales J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_625412_1 1349767.GJA_5516 3.05e-51 162.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VUTM@28216|Betaproteobacteria,478Q6@75682|Oxalobacteraceae 28216|Betaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_625412_2 1215092.PA6_108_00020 1.93e-169 476.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria,1YKUK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_592353_1 1198452.Jab_2c16760 1.25e-95 288.0 COG2207@1|root,COG2207@2|Bacteria,1R7PM@1224|Proteobacteria,2VVAX@28216|Betaproteobacteria,475HN@75682|Oxalobacteraceae 28216|Betaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_811761_1 1122604.JONR01000021_gene561 4.53e-15 73.6 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,1RQ3P@1236|Gammaproteobacteria,1X5PT@135614|Xanthomonadales 135614|Xanthomonadales GK ROK family - - - - - - - - - - - - ROK k59_811761_2 1000565.METUNv1_03431 1.47e-39 132.0 COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2WAK1@28216|Betaproteobacteria,2KZDG@206389|Rhodocyclales 206389|Rhodocyclales S Predicted integral membrane protein (DUF2282) - - - - - - - - - - - - DUF2282 k59_592360_1 497321.C664_16665 2.05e-63 202.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2VI0A@28216|Betaproteobacteria,2KV75@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor switch protein fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_592360_2 640081.Dsui_1750 6.17e-45 150.0 COG1580@1|root,COG1580@2|Bacteria,1RARK@1224|Proteobacteria,2VTGH@28216|Betaproteobacteria,2KWNP@206389|Rhodocyclales 206389|Rhodocyclales N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_1067864_1 1221522.B723_11070 9.36e-45 160.0 COG1524@1|root,COG1524@2|Bacteria,1MUYY@1224|Proteobacteria 1224|Proteobacteria S PFAM PglZ domain - - - - - - - - - - - - PglZ k59_1067864_2 1221522.B723_11075 3.79e-62 207.0 COG4930@1|root,COG4930@2|Bacteria,1MWGE@1224|Proteobacteria,1RQKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent Lon-type protease - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - Lon_2,Lon_C,MIT_C k59_848493_1 614083.AWQR01000017_gene2266 3.32e-95 279.0 COG5573@1|root,COG5573@2|Bacteria,1RDSH@1224|Proteobacteria,2VREG@28216|Betaproteobacteria,4AE9V@80864|Comamonadaceae 28216|Betaproteobacteria S PIN domain vapC - - - - - - - - - - - PIN k59_848493_2 614083.AWQR01000017_gene2267 3.05e-19 85.9 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,4A9XW@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_929058_1 1117647.M5M_04120 6.56e-53 169.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1J670@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_929058_2 1297581.H919_04784 7.9e-59 185.0 COG0386@1|root,COG0386@2|Bacteria,1V3M3@1239|Firmicutes,4HH5Q@91061|Bacilli,21VKX@150247|Anoxybacillus 91061|Bacilli O Glutathione peroxidase bsaA - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_536736_1 1000565.METUNv1_04039 1.04e-26 103.0 COG0810@1|root,COG0810@2|Bacteria,1RFY5@1224|Proteobacteria,2VR5E@28216|Betaproteobacteria 28216|Betaproteobacteria M TonB C terminal - - - - - - - - - - - - TonB_2 k59_536736_2 1000565.METUNv1_04040 1.33e-94 292.0 COG3746@1|root,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,2VNJT@28216|Betaproteobacteria 28216|Betaproteobacteria P Putative porin - - - - - - - - - - - - Porin_5 k59_430553_1 1163617.SCD_n02075 1.46e-64 226.0 COG0784@1|root,COG2198@1|root,COG3850@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG3850@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1 k59_929062_1 1349767.GJA_5235 2.18e-61 193.0 COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,2VRMP@28216|Betaproteobacteria,474SQ@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_465643_1 305700.B447_01751 5.12e-59 196.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VKIS@28216|Betaproteobacteria,2KVRE@206389|Rhodocyclales 206389|Rhodocyclales S FAD-dependent pyridine - - - - - - - - - - - - Pyr_redox_2 k59_1073151_1 1198452.Jab_1c04480 9.16e-66 216.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,475P3@75682|Oxalobacteraceae 28216|Betaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_323562_1 1000565.METUNv1_00993 5.73e-29 123.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_1073155_1 395495.Lcho_1540 3.04e-45 155.0 COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,2VRX3@28216|Betaproteobacteria 28216|Betaproteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - - k59_644821_1 402777.KB235903_gene442 4.5e-05 52.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1659_1 1000565.METUNv1_03266 4.69e-166 471.0 COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,2VJTR@28216|Betaproteobacteria,2KUUH@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT - 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT k59_1659_2 1000565.METUNv1_03267 1.16e-139 402.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VI5H@28216|Betaproteobacteria,2KX2B@206389|Rhodocyclales 206389|Rhodocyclales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_1659_3 1000565.METUNv1_03268 1.04e-29 107.0 COG4654@1|root,COG4654@2|Bacteria,1QZDF@1224|Proteobacteria,2WHK1@28216|Betaproteobacteria,2KZXU@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_465649_1 1122604.JONR01000003_gene1388 3.58e-24 101.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X5SP@135614|Xanthomonadales 135614|Xanthomonadales T Putative diguanylate phosphodiesterase - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,PAS_3,PAS_8,PAS_9 k59_465649_3 1000565.METUNv1_04031 1.72e-33 123.0 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2WGMM@28216|Betaproteobacteria,2KZNU@206389|Rhodocyclales 206389|Rhodocyclales I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_37459_1 1175306.GWL_24570 6.16e-115 346.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,472SG@75682|Oxalobacteraceae 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_37459_2 1000565.METUNv1_01513 2.5e-87 268.0 COG0834@1|root,COG0834@2|Bacteria,1RIGN@1224|Proteobacteria,2VMMR@28216|Betaproteobacteria,2KYWE@206389|Rhodocyclales 206389|Rhodocyclales ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_37459_3 1000565.METUNv1_02219 1.36e-128 381.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUHI@206389|Rhodocyclales 206389|Rhodocyclales G PQQ-like domain - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_929073_2 1000565.METUNv1_02180 5.35e-16 71.2 COG3666@1|root,COG3666@2|Bacteria,1Q0X4@1224|Proteobacteria,2W5U9@28216|Betaproteobacteria,2KZNE@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_72725_1 1000565.METUNv1_02334 1.66e-97 288.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,2KWQ6@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - - - - - - - - - - 5-FTHF_cyc-lig k59_144274_1 391735.Veis_1177 6.07e-103 325.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,4ADF5@80864|Comamonadaceae 28216|Betaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - DUF3883,Helicase_C,ResIII,SNF2_N k59_108574_1 1000565.METUNv1_02369 4.1e-236 664.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_607898_1 1000565.METUNv1_03257 1.69e-106 323.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KUBX@206389|Rhodocyclales 206389|Rhodocyclales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_180714_1 1121033.AUCF01000003_gene3296 1.83e-57 192.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2JR3D@204441|Rhodospirillales 204441|Rhodospirillales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_180714_2 566466.NOR53_2886 0.000214 44.7 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1J9B2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_323588_1 1304883.KI912532_gene2227 5.08e-85 259.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,2KVRT@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_644845_1 1000565.METUNv1_02619 3.07e-07 50.8 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria,2KV3U@206389|Rhodocyclales 206389|Rhodocyclales T Chemotaxis signal transduction protein - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_644845_2 1000565.METUNv1_02618 3.55e-95 285.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria,2KVCH@206389|Rhodocyclales 206389|Rhodocyclales T Chemotaxis signal transduction protein - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_607902_1 1249627.D779_1399 4.14e-54 174.0 COG0745@1|root,COG0745@2|Bacteria,1RGWV@1224|Proteobacteria,1S3TC@1236|Gammaproteobacteria,1WYBZ@135613|Chromatiales 135613|Chromatiales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1073185_2 159087.Daro_3427 9.73e-147 423.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,2KV2M@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_536762_1 1000565.METUNv1_02256 3.64e-130 404.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_822512_1 1000565.METUNv1_00355 2.91e-47 158.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VT9V@28216|Betaproteobacteria,2KZ02@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory proteins, crp family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_822512_2 29581.BW37_03659 9.09e-28 112.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,472VX@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1000939_1 1000565.METUNv1_02318 1.13e-97 290.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2WEFN@28216|Betaproteobacteria,2KW6T@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl-CoA hydratase carnithine racemase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_72734_1 522306.CAP2UW1_1635 2.11e-94 286.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VM08@28216|Betaproteobacteria,1KQ46@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Alcohol dehydrogenase GroES-like domain adh - 1.1.1.1,1.1.1.258 ko:K12957,ko:K13953,ko:K19961 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00930,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00930,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R05283,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_72734_2 1000565.METUNv1_02003 2.21e-36 134.0 COG3211@1|root,COG3211@2|Bacteria,1R690@1224|Proteobacteria,2VMQX@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,VPEP k59_751009_1 1000565.METUNv1_02843 1.93e-62 202.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,2KVI6@206389|Rhodocyclales 206389|Rhodocyclales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_108585_1 998088.B565_0582 6.81e-46 163.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1Y3VZ@135624|Aeromonadales 135624|Aeromonadales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_108585_2 580340.Tlie_1683 2.67e-37 134.0 COG0179@1|root,COG0179@2|Bacteria,3TATB@508458|Synergistetes 508458|Synergistetes Q fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_37481_1 1395571.TMS3_0124985 1.62e-97 300.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_251664_1 1198452.Jab_1c03840 2.8e-36 140.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2VTFV@28216|Betaproteobacteria 28216|Betaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347,HemolysinCabind k59_252384_2 3827.XP_004500763.1 8.82e-05 42.7 2E0P3@1|root,2S834@2759|Eukaryota,37X8F@33090|Viridiplantae,3GMBS@35493|Streptophyta,4JQTN@91835|fabids 35493|Streptophyta J 30S ribosomal protein S31 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009536,GO:0009657,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0032544,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K19033 - - - - br01610,ko00000,ko03011 - - - RPS31 k59_252384_3 700598.Niako_6028 1.08e-07 52.8 COG4942@1|root,COG4942@2|Bacteria 2|Bacteria D peptidase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - PDDEXK_2 k59_38203_1 1000565.METUNv1_02371 2.05e-191 536.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,2KVF4@206389|Rhodocyclales 1224|Proteobacteria G Fructose-1-6-bisphosphatase, N-terminal domain fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11,3.1.3.37 ko:K01086,ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_716438_2 1000565.METUNv1_03038 9.29e-144 415.0 COG0420@1|root,COG0420@2|Bacteria,1MY4X@1224|Proteobacteria,2VJXS@28216|Betaproteobacteria,2KXXW@206389|Rhodocyclales 206389|Rhodocyclales L Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_537285_1 1000565.METUNv1_00168 2.89e-145 420.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KUAY@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_181570_1 395495.Lcho_2036 2.64e-101 320.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KKDW@119065|unclassified Burkholderiales 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_395158_1 543728.Vapar_5778 3.35e-125 364.0 COG0500@1|root,COG2226@2|Bacteria,1PG85@1224|Proteobacteria,2WC4M@28216|Betaproteobacteria,4AIUN@80864|Comamonadaceae 28216|Betaproteobacteria H ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_288070_1 1000565.METUNv1_00499 1.07e-43 147.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VIBS@28216|Betaproteobacteria,2KUSB@206389|Rhodocyclales 206389|Rhodocyclales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Pro_CA k59_288070_2 1163617.SCD_n02805 3.42e-85 268.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2VKXB@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the alkaline phosphatase family phoA2 - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_359534_1 1198452.Jab_2c08080 3.34e-87 275.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,473C1@75682|Oxalobacteraceae 28216|Betaproteobacteria E - Amino acid transport and metabolism asnB1 - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_537286_1 1123399.AQVE01000001_gene675 1.95e-51 165.0 COG1359@1|root,COG1359@2|Bacteria,1N2BB@1224|Proteobacteria,1SRMI@1236|Gammaproteobacteria,4631T@72273|Thiotrichales 72273|Thiotrichales S (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - - - - - - - - - - - k59_537286_2 399739.Pmen_0850 1.32e-69 211.0 COG0599@1|root,COG0599@2|Bacteria,1RH7V@1224|Proteobacteria,1S6K3@1236|Gammaproteobacteria,1YH62@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_645716_1 159087.Daro_1614 7.63e-84 279.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg k59_680060_1 420662.Mpe_A0942 9.08e-60 201.0 2DBNG@1|root,2ZA3W@2|Bacteria,1P5DN@1224|Proteobacteria,2VPD3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1037606_1 543728.Vapar_0561 4.59e-132 382.0 COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2VHZT@28216|Betaproteobacteria,4A9X5@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.5.7 ko:K01502 ko00643,ko01120,map00643,map01120 - R05358 RC01336 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_716452_1 936455.KI421499_gene5482 6.69e-57 205.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JT1B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase MA20_03720 - - - - - - - - - - - EAL,GGDEF,MHYT,PAS_4,PAS_7,PAS_8,PAS_9 k59_751570_1 1000565.METUNv1_02622 4.09e-180 518.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KV2C@206389|Rhodocyclales 206389|Rhodocyclales NT COG0643 Chemotaxis protein histidine kinase and related kinases - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_252411_1 929556.Solca_4469 2.99e-35 129.0 COG0136@1|root,COG0136@2|Bacteria,4NE4V@976|Bacteroidetes,1IQCT@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_645724_1 1395516.PMO01_11510 1.44e-13 69.3 COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,1RQSN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_645724_2 395019.Bmul_4140 5.71e-41 142.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,1K027@119060|Burkholderiaceae 28216|Betaproteobacteria Q fumarylacetoacetate (FAA) hydrolase - - 3.7.1.20 ko:K16165 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R01085 RC00326,RC00446 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_359543_1 338969.Rfer_1942 1.3e-97 289.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria,4ABCH@80864|Comamonadaceae 28216|Betaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_502997_1 1000565.METUNv1_02795 4.03e-146 433.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,2KVAJ@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1001501_1 1157708.KB907450_gene6560 1.16e-19 84.0 COG0071@1|root,COG0071@2|Bacteria,1N535@1224|Proteobacteria,2VVND@28216|Betaproteobacteria,4AF0D@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_109171_1 1000565.METUNv1_00890 6.31e-29 110.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VIY9@28216|Betaproteobacteria,2KYDR@206389|Rhodocyclales 206389|Rhodocyclales M Polysaccharide biosynthesis/export protein gumB - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_109171_2 1000565.METUNv1_00891 2.92e-101 306.0 COG3206@1|root,COG3206@2|Bacteria,1RK0N@1224|Proteobacteria,2VHPS@28216|Betaproteobacteria,2KZRD@206389|Rhodocyclales 206389|Rhodocyclales M G-rich domain on putative tyrosine kinase gumC - - - - - - - - - - - GNVR,Wzz k59_1108504_2 420324.KI912063_gene6695 9.22e-155 448.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,1JRZC@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_01130 - - - - - - - - - - - MFS_1 k59_572928_1 1000565.METUNv1_02942 1.32e-180 510.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales 206389|Rhodocyclales J Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_431481_1 1000565.METUNv1_01006 1.15e-117 357.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VI9T@28216|Betaproteobacteria,2KVW2@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase B/oxoprolinase acxB - 6.4.1.6 ko:K10854 - - - - ko00000,ko01000 - - - Hydantoinase_B k59_431484_1 1123504.JQKD01000008_gene5358 3.67e-115 334.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VPUN@28216|Betaproteobacteria,4AD0X@80864|Comamonadaceae 28216|Betaproteobacteria E Metallopeptidase family M24 - - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_894769_1 1000565.METUNv1_01494 7.81e-36 127.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2VR6A@28216|Betaproteobacteria,2KWI6@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_894769_2 1000565.METUNv1_01495 1.06e-116 339.0 COG1266@1|root,COG1266@2|Bacteria,1RJZQ@1224|Proteobacteria,2VSUQ@28216|Betaproteobacteria 28216|Betaproteobacteria S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_324511_2 862908.BMS_3138 1.78e-17 86.3 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_252434_1 1136138.JH604623_gene3341 5.67e-26 100.0 COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,1S61S@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional liuR - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_252434_2 59538.XP_005979502.1 1.88e-56 186.0 COG1960@1|root,KOG0141@2759|Eukaryota,38CQN@33154|Opisthokonta,3BAWC@33208|Metazoa,3CTM0@33213|Bilateria,4808A@7711|Chordata,48YSQ@7742|Vertebrata,3JC6P@40674|Mammalia,4J50Y@91561|Cetartiodactyla 33208|Metazoa EI isovaleryl-CoA dehydrogenase - GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006551,GO:0006552,GO:0006807,GO:0008150,GO:0008152,GO:0008470,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016491,GO:0016627,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1108517_1 85643.Tmz1t_0597 7.11e-71 231.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,2KUAB@206389|Rhodocyclales 206389|Rhodocyclales O Mg chelatase subunit ChlI - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1108517_2 1000565.METUNv1_03147 2.63e-79 243.0 2B8F5@1|root,321Q6@2|Bacteria,1RKTZ@1224|Proteobacteria,2WHV8@28216|Betaproteobacteria,2KXCY@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1108517_3 1000565.METUNv1_03148 7.25e-42 142.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,2KUYU@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_431504_1 1082931.KKY_707 5.52e-09 63.9 COG5283@1|root,COG5283@2|Bacteria,1R5FU@1224|Proteobacteria,2VFQ8@28211|Alphaproteobacteria,3N7TR@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ - - - - - - - - - - - - - k59_359576_1 1121035.AUCH01000019_gene2870 5.52e-81 245.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VK0C@28216|Betaproteobacteria,2KW5Q@206389|Rhodocyclales 206389|Rhodocyclales K response regulator dctR - - ko:K11712 ko02020,map02020 - - - ko00000,ko00001,ko02022 - - - GerE,Response_reg k59_2260_1 1144313.PMI10_02587 2.01e-61 212.0 COG1629@1|root,COG1629@2|Bacteria,4NF88@976|Bacteroidetes,1HX7Z@117743|Flavobacteriia,2NV7C@237|Flavobacterium 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_38278_1 1000565.METUNv1_00475 1.26e-198 555.0 COG2199@1|root,COG3706@2|Bacteria,1R6GI@1224|Proteobacteria,2VM5N@28216|Betaproteobacteria,2KWR2@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_38278_2 94122.Shewana3_2014 3.89e-39 140.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,2QBE7@267890|Shewanellaceae 1236|Gammaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_716499_1 1000565.METUNv1_03838 6.3e-203 569.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales 28216|Betaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_511865_1 1000565.METUNv1_01666 3.96e-115 349.0 COG2982@1|root,COG2982@2|Bacteria,1RD61@1224|Proteobacteria,2VS09@28216|Betaproteobacteria,2KWG8@206389|Rhodocyclales 206389|Rhodocyclales M AsmA-like C-terminal region - - - - - - - - - - - - AsmA_2 k59_1112792_2 700598.Niako_5792 2.43e-52 166.0 COG0776@1|root,COG0776@2|Bacteria,4NT0D@976|Bacteroidetes,1ISXQ@117747|Sphingobacteriia 976|Bacteroidetes L Belongs to the bacterial histone-like protein family hupA - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_755978_1 640081.Dsui_0728 4.7e-104 315.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,2KUM9@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_655069_1 1218076.BAYB01000022_gene3935 4.26e-127 366.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VJXG@28216|Betaproteobacteria,1KGUX@119060|Burkholderiaceae 28216|Betaproteobacteria G Aldolase - - - - - - - - - - - - Aldolase_II k59_863557_1 1121035.AUCH01000023_gene3442 1.58e-125 377.0 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,2VPI9@28216|Betaproteobacteria,2KXT9@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1083458_1 1144342.PMI40_01878 5.37e-91 275.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,4730B@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_114257_1 925409.KI911562_gene1084 3.43e-96 296.0 COG0614@1|root,COG0614@2|Bacteria,4PNPI@976|Bacteroidetes 976|Bacteroidetes P abc-type fe3 -hydroxamate transport system, periplasmic component - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_114257_2 925409.KI911562_gene1083 3.16e-17 80.9 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1J0P3@117747|Sphingobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - GO:0001871,GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009987,GO:0010467,GO:0016020,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030246,GO:0030247,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:2001070 - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_333235_1 398527.Bphyt_6719 3.97e-49 177.0 COG3614@1|root,COG5001@1|root,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_934478_1 1028801.RG1141_CH14800 1.76e-14 72.4 2CS66@1|root,32SQF@2|Bacteria,1MZFX@1224|Proteobacteria,2V6NH@28211|Alphaproteobacteria,4BKPF@82115|Rhizobiaceae 28211|Alphaproteobacteria S Family of unknown function (DUF5343) - - - - - - - - - - - - DUF5343 k59_934478_2 1198452.Jab_1c04600 4.86e-18 83.2 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,2VHYS@28216|Betaproteobacteria 28216|Betaproteobacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_611936_1 1000565.METUNv1_00289 1.22e-128 369.0 COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,2VI3H@28216|Betaproteobacteria,2KXZR@206389|Rhodocyclales 206389|Rhodocyclales S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - - k59_440799_1 987059.RBXJA2T_17559 1.07e-09 58.5 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,1KK8R@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_149859_1 338969.Rfer_3379 2.61e-134 388.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,4AAWG@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family urtC - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_934481_2 1504672.669784480 2.78e-41 146.0 COG2941@1|root,COG3011@1|root,COG2941@2|Bacteria,COG3011@2|Bacteria,1PSDW@1224|Proteobacteria,2VUPG@28216|Betaproteobacteria,4AIAR@80864|Comamonadaceae 28216|Betaproteobacteria H Protein of unknown function, DUF393 - - - - - - - - - - - - COQ7,DUF393 k59_934481_3 1000565.METUNv1_03416 9.58e-34 134.0 COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_970166_1 76114.ebA3749 1.96e-32 116.0 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,2KVY3@206389|Rhodocyclales 206389|Rhodocyclales E Lactoylglutathione lyase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_863587_1 1313421.JHBV01000024_gene5052 5.18e-51 171.0 COG3279@1|root,COG3279@2|Bacteria,4NHI4@976|Bacteroidetes 976|Bacteroidetes T LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_934495_1 1000565.METUNv1_03462 5.64e-102 311.0 COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,2KXG7@206389|Rhodocyclales 206389|Rhodocyclales S Alkaline phosphatase - - - - - - - - - - - - - k59_440851_1 1000565.METUNv1_03746 8.6e-43 150.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VP40@28216|Betaproteobacteria,2KUSJ@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_440851_2 1000565.METUNv1_03745 3.04e-34 125.0 COG0476@1|root,COG0476@2|Bacteria,1QUMS@1224|Proteobacteria,2VN2Y@28216|Betaproteobacteria,2KUIK@206389|Rhodocyclales 206389|Rhodocyclales H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 - - - - - - - - - - - - ThiF k59_79636_1 391735.Veis_2335 2.29e-35 134.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,4A9JQ@80864|Comamonadaceae 28216|Betaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_79636_2 365046.Rta_36260 2.78e-79 243.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,4A9KZ@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_970192_1 1095769.CAHF01000003_gene968 7.45e-94 279.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,472AK@75682|Oxalobacteraceae 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_149902_1 1000565.METUNv1_01119 1.27e-154 443.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,2KVDB@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_149902_2 1000565.METUNv1_01118 1.89e-12 62.0 COG2938@1|root,COG2938@2|Bacteria 2|Bacteria C An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH sdhE GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 1.3.5.1,1.3.5.4 ko:K00240,ko:K09159 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000,ko02048 - - - Sdh5 k59_793790_1 398578.Daci_2771 1.08e-69 225.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,4AA7T@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_793790_2 338969.Rfer_2628 2.01e-125 362.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,4ABTB@80864|Comamonadaceae 28216|Betaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_970203_1 272562.CA_C2522 6.04e-07 52.4 COG0463@1|root,COG0463@2|Bacteria,1V3ZF@1239|Firmicutes,24INV@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_44088_2 596153.Alide_1665 2.14e-10 58.9 2E6H8@1|root,3314G@2|Bacteria,1NFU2@1224|Proteobacteria,2VX6F@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_793801_1 1120977.JHUX01000005_gene2753 1.61e-60 210.0 COG1570@1|root,COG1570@2|Bacteria,1QWH2@1224|Proteobacteria,1T2VA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_1008093_1 1401065.HMPREF2130_01595 3.04e-26 108.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,3T1K5@506|Alcaligenaceae 28216|Betaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_1008096_1 748247.AZKH_3032 6.5e-54 185.0 COG2206@1|root,COG2206@2|Bacteria,1MWDU@1224|Proteobacteria,2VIAF@28216|Betaproteobacteria,2KZ48@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_114337_2 351016.RAZWK3B_12834 1.72e-29 119.0 COG3258@1|root,COG3474@1|root,COG3258@2|Bacteria,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,2P23W@2433|Roseobacter 28211|Alphaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III soxD - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_219609_2 1341151.ASZU01000006_gene2772 1.42e-05 48.1 COG1547@1|root,COG1547@2|Bacteria,1V7AS@1239|Firmicutes,4HNQM@91061|Bacilli,27CEC@186824|Thermoactinomycetaceae 91061|Bacilli S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 k59_1112867_1 768671.ThimaDRAFT_3752 3.71e-47 171.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WXJY@135613|Chromatiales 135613|Chromatiales CO Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbC,DsbD,Thioredoxin_7 k59_512027_1 1175306.GWL_01800 2.71e-171 489.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,472R1@75682|Oxalobacteraceae 28216|Betaproteobacteria G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1008098_1 207559.Dde_3425 3.12e-39 144.0 COG0732@1|root,COG0732@2|Bacteria,1R5R8@1224|Proteobacteria,42Q25@68525|delta/epsilon subdivisions,2WMEQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_542118_1 1219031.BBJR01000001_gene637 1.8e-12 62.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria,4AF0Y@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_542118_2 887062.HGR_00170 4.45e-65 202.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,4ADPE@80864|Comamonadaceae 28216|Betaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_472158_1 338969.Rfer_2273 1.09e-107 320.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,4AC1Q@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family bktB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_829772_1 543728.Vapar_1635 4.57e-107 322.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4AB5M@80864|Comamonadaceae 28216|Betaproteobacteria T TIGRFAM nitrogen regulation protein NR(I) ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_655234_1 1454004.AW11_00061 6.61e-76 239.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VKXU@28216|Betaproteobacteria 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_829775_1 1219031.BBJR01000040_gene2696 0.000658 41.2 COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria,4ACV5@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_829775_2 1000565.METUNv1_01841 1.38e-47 164.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,2KVJH@206389|Rhodocyclales 206389|Rhodocyclales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_5 k59_512044_1 1123261.AXDW01000009_gene106 8.37e-13 73.6 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,1RZRJ@1236|Gammaproteobacteria,1XA50@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - GT87 k59_44114_1 365046.Rta_19080 1.8e-10 61.2 COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2VHNW@28216|Betaproteobacteria,4AAB6@80864|Comamonadaceae 28216|Betaproteobacteria E Cys Met metabolism pyridoxal-phosphate-dependent metC - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_44114_2 338969.Rfer_2230 3.43e-09 54.3 2EGJB@1|root,33ABH@2|Bacteria,1NI1G@1224|Proteobacteria,2VXT5@28216|Betaproteobacteria,4AFVV@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_191869_1 614083.AWQR01000028_gene3175 1.35e-160 471.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,4AB1Y@80864|Comamonadaceae 28216|Betaproteobacteria KL SMART helicase c2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_295669_1 887062.HGR_13674 3.89e-89 276.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,2VINN@28216|Betaproteobacteria,4ABA4@80864|Comamonadaceae 28216|Betaproteobacteria L Exonuclease, RNase T and DNA polymerase III sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_756681_2 744872.Spica_1877 1.65e-21 87.8 COG0864@1|root,COG0864@2|Bacteria,2J98M@203691|Spirochaetes 203691|Spirochaetes K Transcriptional regulator - - - - - - - - - - - - NikR_C k59_472923_1 596154.Alide2_3812 8.87e-114 330.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VKH2@28216|Betaproteobacteria,4ACGF@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase, catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_935163_1 267608.RSc2263 4.69e-36 133.0 2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,1K3DF@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 k59_935163_2 335284.Pcryo_0148 9.73e-57 193.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,3NK5D@468|Moraxellaceae 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_366505_1 1500894.JQNN01000001_gene3237 1.57e-105 329.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,472M6@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_472926_1 399795.CtesDRAFT_PD3960 3.2e-85 285.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,4ABJ6@80864|Comamonadaceae 28216|Betaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin PilY1-like protein pilY - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_656488_1 1223521.BBJX01000007_gene1583 3.44e-209 600.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,4AAEC@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_191890_1 1000565.METUNv1_03390 8.04e-50 169.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,2KU7G@206389|Rhodocyclales 206389|Rhodocyclales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein rnfF - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_191890_2 1000565.METUNv1_03389 1.34e-115 338.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,2KUJJ@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_830514_1 397945.Aave_3041 3.8e-21 90.1 COG1116@1|root,COG1116@2|Bacteria,1MUKI@1224|Proteobacteria,2VMBI@28216|Betaproteobacteria,4AAP9@80864|Comamonadaceae 28216|Betaproteobacteria P Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system ssuB - - ko:K15555 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.2 - - ABC_tran k59_830514_2 1268622.AVS7_01382 1.13e-34 119.0 COG3585@1|root,COG3585@2|Bacteria,1N06J@1224|Proteobacteria,2WG91@28216|Betaproteobacteria,4AEYI@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM TOBE domain protein ssuF - - - - - - - - - - - TOBE k59_830514_3 365044.Pnap_0564 3.23e-10 60.1 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VM7G@28216|Betaproteobacteria,4AD6B@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Sigma54_activat k59_1084892_2 666681.M301_0899 4.58e-43 150.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,2KM43@206350|Nitrosomonadales 206350|Nitrosomonadales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1043812_1 365044.Pnap_0242 1.08e-92 279.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,4AAQD@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_44851_1 857571.EA1_01396 1.54e-71 224.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,3NJR4@468|Moraxellaceae 1236|Gammaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_442240_1 700598.Niako_4998 3.3e-73 244.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1J0TP@117747|Sphingobacteriia 976|Bacteroidetes H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_722096_2 1244869.H261_11094 9.81e-25 103.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TTX9@28211|Alphaproteobacteria,2JPNC@204441|Rhodospirillales 204441|Rhodospirillales M HlyD family secretion protein - - - ko:K02022 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1043822_1 1266908.AQPB01000051_gene2466 1.04e-40 155.0 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,1S4MJ@1236|Gammaproteobacteria,1X0RU@135613|Chromatiales 135613|Chromatiales S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_44869_1 1123367.C666_07405 5.94e-123 355.0 COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,2VRVY@28216|Betaproteobacteria,2KVK5@206389|Rhodocyclales 206389|Rhodocyclales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_830557_1 1000565.METUNv1_00132 2.05e-62 199.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,2KU6A@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_830557_2 1000565.METUNv1_00133 9.53e-66 210.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,2KV6H@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_542815_1 1000565.METUNv1_00468 3.79e-139 404.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,2KVP0@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_472985_1 640081.Dsui_0963 1.61e-40 143.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,2VISF@28216|Betaproteobacteria,2KUYD@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase family U32 - - - - - - - - - - - - Peptidase_U32 k59_472985_2 580332.Slit_0581 1.65e-46 153.0 COG3154@1|root,COG3154@2|Bacteria,1RB7T@1224|Proteobacteria,2VTWW@28216|Betaproteobacteria 28216|Betaproteobacteria I Sterol-binding domain protein - - - - - - - - - - - - SCP2 k59_656571_2 1502852.FG94_03524 2.38e-42 148.0 2E3S7@1|root,32YPT@2|Bacteria,1N7D4@1224|Proteobacteria,2VUS8@28216|Betaproteobacteria,476IC@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_935212_1 313606.M23134_08158 1.8e-30 124.0 COG0457@1|root,COG2208@1|root,COG0457@2|Bacteria,COG2208@2|Bacteria,4NJKM@976|Bacteroidetes,47NZZ@768503|Cytophagia 976|Bacteroidetes KT Stage II sporulation protein E (SpoIIE) - - - - - - - - - - - - SpoIIE,TPR_12,TPR_8 k59_442287_1 1121035.AUCH01000003_gene1320 1.64e-140 414.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,2KVJZ@206389|Rhodocyclales 206389|Rhodocyclales I carboxylase pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_836757_1 338969.Rfer_0702 3.27e-63 210.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,4ACXV@80864|Comamonadaceae 28216|Betaproteobacteria M Bacterial sugar transferase wcaJ - 2.7.8.40 ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_524247_1 930169.B5T_03557 7.16e-49 167.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XHYN@135619|Oceanospirillales 135619|Oceanospirillales D Reduces the stability of FtsZ polymers in the presence of ATP zapE - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_802031_1 194699.Q775D3_BPBPP 7.8e-89 284.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNG7@10744|Podoviridae 10744|Podoviridae S lytic transglycosylase activity - GO:0008150,GO:0016032,GO:0019058,GO:0030260,GO:0039678,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0046718,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_524248_1 1000565.METUNv1_04045 3.82e-86 286.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_728735_1 338969.Rfer_3421 4.11e-109 324.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,4A9UG@80864|Comamonadaceae 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_123441_2 359.CN09_09195 4.19e-09 54.3 28UES@1|root,2ZGJS@2|Bacteria,1PBHX@1224|Proteobacteria,2UW6B@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_304993_1 864051.BurJ1DRAFT_3943 5.28e-113 333.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,1KKF7@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_693379_1 497964.CfE428DRAFT_4469 4.99e-79 271.0 COG3511@1|root,COG3540@1|root,COG3511@2|Bacteria,COG3540@2|Bacteria,46UZ7@74201|Verrucomicrobia 74201|Verrucomicrobia M Phosphoesterase family - - 3.1.4.3 ko:K01114 ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919 - R01312,R02027,R02052,R03332,R07381 RC00017,RC00425 ko00000,ko00001,ko01000,ko02042 - - - Phosphoesterase k59_551563_1 1000565.METUNv1_00103 2.24e-163 475.0 COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria,2KUK9@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase-like ATPases - - - - - - - - - - - - - k59_455364_1 1206737.BAGF01000142_gene5701 8.53e-26 101.0 2A4XC@1|root,30TJ6@2|Bacteria,2I8C7@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_455364_2 1217713.F993_00614 1.07e-14 73.9 28TBT@1|root,2ZFK9@2|Bacteria,1QPYG@1224|Proteobacteria,1TNQV@1236|Gammaproteobacteria,3NR4B@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_204664_1 331869.BAL199_23729 1.05e-43 151.0 COG2199@1|root,COG3706@2|Bacteria,1QZ3H@1224|Proteobacteria,2TY4B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_941859_1 640512.BC1003_2952 3.37e-10 62.8 COG0500@1|root,COG0859@1|root,COG0859@2|Bacteria,COG2226@2|Bacteria,1QUID@1224|Proteobacteria,2WHCP@28216|Betaproteobacteria,1K0X0@119060|Burkholderiaceae 28216|Betaproteobacteria MQ Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9,Methyltransf_23 k59_941859_2 243233.MCA1513 2.96e-41 143.0 COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria 1224|Proteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - Glyco_transf_8 k59_52843_1 688245.CtCNB1_4573 3.24e-57 186.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,4AA97@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM Thioredoxin domain - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_52843_2 1123255.JHYS01000014_gene563 8.1e-30 109.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,4ADQH@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_618873_1 1156919.QWC_12613 4.55e-06 55.1 2EK6T@1|root,33DX6@2|Bacteria,1PHQT@1224|Proteobacteria,2W4KB@28216|Betaproteobacteria 2|Bacteria S overlaps another CDS with the same product name - - - - - - - - - - - - Pectate_lyase_3,Peptidase_S74 k59_1054340_1 1242864.D187_004469 7.38e-12 65.5 29AZZ@1|root,30PVG@2|Bacteria,1Q1Z7@1224|Proteobacteria,434V6@68525|delta/epsilon subdivisions,2WZ6B@28221|Deltaproteobacteria,2Z1F3@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_669895_1 1415630.U771_13900 1.99e-72 238.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_763617_1 194699.Q775D1_BPBPP 1.18e-86 276.0 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_551593_1 1316936.K678_10726 4.27e-11 63.5 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2TVPG@28211|Alphaproteobacteria,2JRR0@204441|Rhodospirillales 204441|Rhodospirillales P carbonic anhydrase - - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase k59_873269_1 1276756.AUEX01000024_gene48 3.32e-111 331.0 COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,2VI4N@28216|Betaproteobacteria,4AC50@80864|Comamonadaceae 28216|Betaproteobacteria O Cytochrome C assembly protein ccsB - - - - - - - - - - - Cytochrom_C_asm k59_551594_1 1157708.KB907463_gene852 3.64e-64 196.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,4ADWK@80864|Comamonadaceae 28216|Betaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_551594_2 1158292.JPOE01000002_gene3721 4.76e-08 53.1 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,1KJXX@119065|unclassified Burkholderiales 28216|Betaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_347773_1 614083.AWQR01000033_gene2854 5.63e-177 500.0 COG0683@1|root,COG0683@2|Bacteria,1N1MX@1224|Proteobacteria,2VJMT@28216|Betaproteobacteria,4AC97@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_375717_1 614083.AWQR01000031_gene2613 3.96e-05 44.7 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,4AAY1@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_375717_2 296591.Bpro_3065 3.14e-52 165.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,4AEG8@80864|Comamonadaceae 28216|Betaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_551600_1 338969.Rfer_0198 1.09e-60 195.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,4AA97@80864|Comamonadaceae 28216|Betaproteobacteria O PFAM Thioredoxin domain - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_803559_1 83406.HDN1F_18670 9.57e-103 314.0 COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1J5C7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iECDH10B_1368.ECDH10B_2448,iECDH1ME8569_1439.ECDH1ME8569_2223,iETEC_1333.ETEC_2421,iEcDH1_1363.EcDH1_1371,iPC815.YPO2553,iUMNK88_1353.UMNK88_2836 Complex1_30kDa,Complex1_49kDa k59_803559_2 1122951.ATUE01000005_gene1803 5.96e-05 44.3 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,3NK9H@468|Moraxellaceae 1236|Gammaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iYL1228.KPN_02675 2Fe-2S_thioredx k59_838216_1 1276756.AUEX01000035_gene2222 2.43e-16 77.4 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,4A9JB@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_838216_2 614083.AWQR01000017_gene2303 2.84e-43 145.0 2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,2WAGW@28216|Betaproteobacteria,4AEUM@80864|Comamonadaceae 28216|Betaproteobacteria S CNP1-like family - - - - - - - - - - - - CNP1 k59_730112_1 1236959.BAMT01000014_gene2871 8.02e-62 207.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2VI7W@28216|Betaproteobacteria,2KNHB@206350|Nitrosomonadales 206350|Nitrosomonadales L Recombinase zinc beta ribbon domain - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_408497_1 1267211.KI669560_gene721 2.05e-24 94.0 COG0599@1|root,COG0599@2|Bacteria,4NNRB@976|Bacteroidetes,1ISNQ@117747|Sphingobacteriia 976|Bacteroidetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_408497_2 237368.SCABRO_03886 2.4e-32 115.0 2CCSR@1|root,32RWC@2|Bacteria,2J1M5@203682|Planctomycetes 203682|Planctomycetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_375738_1 1268622.AVS7_01568 1.32e-102 305.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,4AARU@80864|Comamonadaceae 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_375738_2 1223521.BBJX01000023_gene3078 8.55e-05 43.1 COG3312@1|root,COG3312@2|Bacteria,1RJ13@1224|Proteobacteria,2VT87@28216|Betaproteobacteria,4AEH3@80864|Comamonadaceae 28216|Betaproteobacteria C ATP synthase - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATP-synt_I k59_669946_1 1267535.KB906767_gene3517 1.22e-21 97.1 COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria,2JMXU@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_909092_1 1318628.MARLIPOL_14495 6.82e-27 114.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,46A57@72275|Alteromonadaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CZB,EAL,GAF_2,GGDEF,Hemerythrin,PAS_4,PAS_9,Protoglobin k59_1016371_2 1304883.KI912532_gene585 2.13e-58 190.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2VNH9@28216|Betaproteobacteria,2KU7D@206389|Rhodocyclales 206389|Rhodocyclales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_978843_1 29581.BW37_01882 5.63e-96 299.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,473A6@75682|Oxalobacteraceae 28216|Betaproteobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_87796_1 1000565.METUNv1_02097 2.06e-131 378.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,2KVHR@206389|Rhodocyclales 206389|Rhodocyclales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_16512_2 338963.Pcar_1576 1.41e-35 130.0 COG0842@1|root,COG0842@2|Bacteria,1PD5Q@1224|Proteobacteria,42TZM@68525|delta/epsilon subdivisions,2WQ44@28221|Deltaproteobacteria 28221|Deltaproteobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_763669_2 690597.JH730961_gene4395 5.22e-38 137.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RPBX@1236|Gammaproteobacteria,1YN1W@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria ET ABC transporter gltI GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - iECH74115_1262.ECH74115_0748,iECSE_1348.ECSE_0725,iECSP_1301.ECSP_0707,iECW_1372.ECW_m0710,iECs_1301.ECs0694,iEKO11_1354.EKO11_3211,iG2583_1286.G2583_0819,iSFV_1184.SFV_0671,iSF_1195.SF0626,iS_1188.S0648,iWFL_1372.ECW_m0710,iZ_1308.Z0805 SBP_bac_3 k59_763670_1 62928.azo0455 7.65e-82 257.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,2KUZW@206389|Rhodocyclales 206389|Rhodocyclales S Cobalamin synthesis protein cobW C-terminal domain - - - - - - - - - - - - CobW_C,cobW k59_693467_1 1100720.ALKN01000031_gene1266 9.41e-113 330.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,4AAVN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_1121244_1 887062.HGR_00475 1.18e-91 281.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,4A9JN@80864|Comamonadaceae 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_204795_1 935567.JAES01000017_gene2432 2.62e-78 252.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_267893_1 497321.C664_01350 1.1e-66 238.0 COG5281@1|root,COG5283@1|root,COG5281@2|Bacteria,COG5283@2|Bacteria,1QZFN@1224|Proteobacteria 1224|Proteobacteria D domain protein - - - - - - - - - - - - - k59_52924_1 292415.Tbd_2823 6.01e-54 182.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2VIPG@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_455513_1 1236501.BAJU01000001_gene5 4.86e-07 53.5 COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_455513_2 491952.Mar181_1577 4.9e-17 83.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,1XJM9@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_9 k59_481709_1 338969.Rfer_1217 9.46e-37 134.0 2B80Y@1|root,3218R@2|Bacteria,1RJ6E@1224|Proteobacteria,2VUZ8@28216|Betaproteobacteria,4AHIH@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4337) - - - - - - - - - - - - DUF4337 k59_618929_2 596153.Alide_3593 4.68e-15 75.5 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_978888_1 1123367.C666_10205 2.55e-94 297.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VM93@28216|Betaproteobacteria,2KXZC@206389|Rhodocyclales 206389|Rhodocyclales NT Pfam:Cache_1 - - - - - - - - - - - - HAMP,MCPsignal,dCache_1 k59_1092025_1 375286.mma_2769 4.9e-114 338.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2VJ0N@28216|Betaproteobacteria 28216|Betaproteobacteria OU PFAM peptidase S49 - - - - - - - - - - - - Peptidase_S49 k59_1092025_2 375286.mma_2768 2.77e-21 91.7 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2VKKT@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_204832_2 292.DM42_1422 4.28e-41 145.0 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2VKF6@28216|Betaproteobacteria,1K1M5@119060|Burkholderiaceae 28216|Betaproteobacteria C glycerophosphoryl diester phosphodiesterase ugpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_481736_2 159087.Daro_1934 1.09e-24 107.0 COG0784@1|root,COG3290@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1 k59_204844_1 1397284.AYMN01000010_gene2944 6.26e-83 256.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,40127@613|Serratia 1236|Gammaproteobacteria S Alanine dehydrogenase/PNT, C-terminal domain yahK - - ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_123576_1 1304883.KI912532_gene440 1.31e-71 235.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,2KUCJ@206389|Rhodocyclales 206389|Rhodocyclales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_204859_1 1313301.AUGC01000006_gene44 3.88e-73 243.0 COG0495@1|root,COG0495@2|Bacteria,4NE5K@976|Bacteroidetes 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,DUF559,tRNA-synt_1,tRNA-synt_1_2 k59_551726_1 1000565.METUNv1_01141 1.58e-132 394.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,2KUTN@206389|Rhodocyclales 206389|Rhodocyclales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1016453_1 1000565.METUNv1_03642 1.87e-41 147.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KV3Q@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN1 - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1016453_2 1000565.METUNv1_03641 2.44e-63 194.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,2KWTT@206389|Rhodocyclales 206389|Rhodocyclales J sigma 54 modulation protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_52981_1 349521.HCH_05456 2.55e-50 172.0 COG0745@1|root,COG2172@1|root,COG0745@2|Bacteria,COG2172@2|Bacteria,1R7VB@1224|Proteobacteria,1S026@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator receiver - - - - - - - - - - - - HATPase_c_2,Response_reg k59_455614_1 406124.ACPC01000020_gene3905 5.74e-20 90.9 COG0463@1|root,COG0463@2|Bacteria,1TSFF@1239|Firmicutes,4HCPR@91061|Bacilli,1ZS5R@1386|Bacillus 91061|Bacilli M Glycosyltransferase like family 2 tuaG - - ko:K16698 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_585587_1 1122970.AUHC01000025_gene22 7.44e-69 228.0 2A4DH@1|root,2ZZED@2|Bacteria,1PNT6@1224|Proteobacteria,2V1C3@28211|Alphaproteobacteria,2KBCW@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_701862_3 395495.Lcho_1351 3.38e-13 65.9 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,2VR48@28216|Betaproteobacteria,1KKXN@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Nitrogen fixation protein NifX nifX - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_315864_2 1158050.KB895457_gene2300 7.84e-20 85.1 COG0662@1|root,COG0662@2|Bacteria,2IKT6@201174|Actinobacteria 201174|Actinobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_916648_1 1158756.AQXQ01000011_gene603 7.77e-25 107.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X0GR@135613|Chromatiales 135613|Chromatiales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3 k59_491730_1 497321.C664_06738 2.63e-60 192.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VPW8@28216|Betaproteobacteria,2KVSD@206389|Rhodocyclales 206389|Rhodocyclales C Heme copper-type cytochrome quinol oxidase, subunit 3 - - - ko:K02164 - - R00294 RC02794 ko00000 3.D.4.10 - - COX3 k59_491730_2 1121035.AUCH01000016_gene2131 7.21e-08 51.2 2EH8J@1|root,33B0E@2|Bacteria,1NEWF@1224|Proteobacteria,2VXG1@28216|Betaproteobacteria,2KX83@206389|Rhodocyclales 206389|Rhodocyclales S Prokaryotic Cytochrome C oxidase subunit IV - - - - - - - - - - - - COX4_pro k59_916665_1 1198452.Jab_2c23900 5.87e-61 194.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2VIU6@28216|Betaproteobacteria,473JQ@75682|Oxalobacteraceae 28216|Betaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_916665_2 1198452.Jab_2c23890 2.97e-17 78.6 COG3190@1|root,COG3190@2|Bacteria,1PQ30@1224|Proteobacteria,2VWHP@28216|Betaproteobacteria,47529@75682|Oxalobacteraceae 28216|Betaproteobacteria N Flagellar biosynthesis protein, FliO fliO - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO k59_1025889_1 700598.Niako_4137 5.36e-64 211.0 COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,1IQ7X@117747|Sphingobacteriia 976|Bacteroidetes D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C k59_770944_1 1095769.CAHF01000001_gene3457 3.07e-43 159.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,472Y3@75682|Oxalobacteraceae 28216|Betaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_770944_2 1175306.GWL_02160 6.08e-12 68.6 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,47344@75682|Oxalobacteraceae 28216|Betaproteobacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_562001_1 864073.HFRIS_006954 4.16e-17 79.7 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,473WZ@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Major facilitator superfamily lplT - - - - - - - - - - - MFS_1 k59_562001_2 1005048.CFU_2423 5.75e-33 124.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,472AV@75682|Oxalobacteraceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_1129353_2 498211.CJA_1323 9.65e-51 178.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1FH3I@10|Cellvibrio 1236|Gammaproteobacteria C Domain of unknown function (DUF3362) ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_737879_2 1122951.ATUE01000005_gene2001 7.13e-71 222.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,3NJW4@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0282,ic_1306.c0493 F420_oxidored,P5CR_dimer k59_1067577_1 1239415.CM001837_gene1439 3.78e-86 271.0 COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,1HXYZ@117743|Flavobacteriia,37E09@326319|Dokdonia 976|Bacteroidetes C Cytochrome C and Quinol oxidase polypeptide I coxN - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_770979_1 1123367.C666_11875 3.7e-33 134.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KXVB@206389|Rhodocyclales 206389|Rhodocyclales T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,dCache_1 k59_882596_1 1122951.ATUE01000007_gene782 8.54e-113 328.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,3NIVD@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_491845_1 903818.KI912269_gene318 1.56e-21 94.0 COG2199@1|root,COG3706@2|Bacteria,3Y80X@57723|Acidobacteria 57723|Acidobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_491845_2 583345.Mmol_0541 3.91e-65 216.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,2KM2J@206350|Nitrosomonadales 206350|Nitrosomonadales C TIGRFAM cytochrome c oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_592233_1 1538295.JY96_05470 4.31e-79 255.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria,1KPG2@119065|unclassified Burkholderiales 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1129401_1 1502852.FG94_00625 1.99e-44 164.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_592252_1 1198452.Jab_1c09000 1.38e-156 465.0 COG1196@1|root,COG1196@2|Bacteria,1NGZ2@1224|Proteobacteria,2VIWY@28216|Betaproteobacteria,476FU@75682|Oxalobacteraceae 28216|Betaproteobacteria D P-loop containing region of AAA domain - - - - - - - - - - - - AAA_21,AAA_29,SMC_N k59_168378_1 640081.Dsui_1650 1.77e-39 149.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,2KU93@206389|Rhodocyclales 206389|Rhodocyclales P ATPase, P-type (transporting), HAD superfamily, subfamily IC copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_882611_3 754331.AEME01000001_gene15 1.09e-20 102.0 COG1835@1|root,COG1835@2|Bacteria,1P5AN@1224|Proteobacteria,1RYT0@1236|Gammaproteobacteria,3XQM9@561|Escherichia 1236|Gammaproteobacteria I DNA/protein translocase of phage P22 injectosome - - - - - - - - - - - - Inj_translocase k59_882611_4 10754.VG16_BPP22 5.83e-15 87.4 4QEN7@10239|Viruses,4QW0U@35237|dsDNA viruses no RNA stage,4QSNP@28883|Caudovirales,4QNFM@10744|Podoviridae 10744|Podoviridae S viral entry into host cell - GO:0006810,GO:0008150,GO:0016032,GO:0019058,GO:0030260,GO:0039678,GO:0044403,GO:0044409,GO:0044419,GO:0044766,GO:0046718,GO:0046794,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0099002,GO:1902579 - - - - - - - - - - - k59_563613_3 1042209.HK44_020735 9.52e-62 214.0 28PW1@1|root,2ZCGG@2|Bacteria,1R4C8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_235804_1 485918.Cpin_5021 5.82e-61 194.0 COG0637@1|root,COG0637@2|Bacteria,4NPDJ@976|Bacteroidetes,1IXJG@117747|Sphingobacteriia 976|Bacteroidetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_1130968_1 1209072.ALBT01000045_gene2658 1.11e-35 125.0 COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,1SABC@1236|Gammaproteobacteria,1FIAA@10|Cellvibrio 1236|Gammaproteobacteria S PRC-barrel domain - - - - - - - - - - - - PRC k59_1027769_1 1122236.KB905146_gene1897 5.59e-61 203.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KKF0@206350|Nitrosomonadales 206350|Nitrosomonadales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_739460_1 1349767.GJA_3205 3.97e-73 229.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,47351@75682|Oxalobacteraceae 28216|Betaproteobacteria F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_885194_1 1000565.METUNv1_00181 6.46e-77 231.0 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2VT6I@28216|Betaproteobacteria,2KZAQ@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the Fur family - - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_134027_1 857087.Metme_2375 2.48e-09 61.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales 135618|Methylococcales T Diguanylate cyclase phosphodiesterase with PAS PAC - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_134027_2 700598.Niako_6192 7.18e-14 70.9 COG3287@1|root,COG3287@2|Bacteria,4NGTB@976|Bacteroidetes,1IW55@117747|Sphingobacteriia 976|Bacteroidetes S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_1070358_1 580332.Slit_2306 1.02e-25 107.0 2DRTJ@1|root,33CZM@2|Bacteria,1QF7V@1224|Proteobacteria,2VXR2@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3617) - - - - - - - - - - - - DUF3617 k59_950641_1 1000565.METUNv1_02804 1.94e-48 166.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,2KVAD@206389|Rhodocyclales 206389|Rhodocyclales H Molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_950641_2 1000565.METUNv1_02803 9.14e-44 145.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KWDE@206389|Rhodocyclales 206389|Rhodocyclales H molybdopterin-guanine dinucleotide biosynthesis protein - - - ko:K03753 - - - - ko00000 - - - MobB k59_1130992_1 1005048.CFU_0453 6.16e-28 110.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,472MX@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type IV pilus assembly protein PilM; pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_563642_1 1304865.JAGF01000001_gene1215 2.4e-67 228.0 COG0643@1|root,COG0643@2|Bacteria,2IBKY@201174|Actinobacteria,4F1S9@85016|Cellulomonadaceae 201174|Actinobacteria T Histidine Phosphotransfer domain cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_318090_2 1000565.METUNv1_01832 3.18e-76 237.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,2KVNC@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_563644_2 438753.AZC_3592 2.1e-45 155.0 COG0258@1|root,COG0258@2|Bacteria,1MYSI@1224|Proteobacteria,2U60N@28211|Alphaproteobacteria 28211|Alphaproteobacteria L 5'-3' exonuclease, N-terminal resolvase-like domain - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc_N k59_1131011_1 395495.Lcho_1161 1.66e-248 711.0 COG1203@1|root,COG1203@2|Bacteria,1MX7A@1224|Proteobacteria,2VJQY@28216|Betaproteobacteria,1KMWW@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DEAD DEAH box helicase - - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD,Helicase_C k59_1131011_2 243233.MCA0656 4.7e-59 187.0 2DBAF@1|root,2Z82V@2|Bacteria,1MWRM@1224|Proteobacteria,1RWB1@1236|Gammaproteobacteria,1XF97@135618|Methylococcales 135618|Methylococcales S CRISPR-associated protein (Cas_Cas5) - - - ko:K19119 - - - - ko00000,ko02048 - - - Cas_Cas5d k59_885276_1 755732.Fluta_0300 4.39e-34 133.0 COG5107@1|root,COG5107@2|Bacteria,4NEPG@976|Bacteroidetes,1IKD1@117743|Flavobacteriia,2PAST@246874|Cryomorphaceae 976|Bacteroidetes A Domain of Unknown Function (DUF349) - - - - - - - - - - - - DUF349 k59_390015_1 522306.CAP2UW1_1355 1.72e-101 313.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,1KQM5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_8 k59_134073_1 50452.A0A087H8D5 2.49e-24 107.0 COG1171@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1250@2759|Eukaryota,37NRU@33090|Viridiplantae,3GGV0@35493|Streptophyta,3HXPF@3699|Brassicales 35493|Streptophyta I 3-hydroxyisobutyryl-CoA hydrolase activity - GO:0000943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003887,GO:0003964,GO:0004518,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006508,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019538,GO:0032196,GO:0032197,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140096,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576 - - - - - - - - - - Chromo,RVP_2,RVT_1,Retrotrans_gag,rve k59_62939_1 1000565.METUNv1_00145 6.32e-120 358.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,2KUNQ@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_318134_1 1198452.Jab_2c01170 2.63e-164 473.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,473HJ@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_278800_1 1353529.M899_2210 1.29e-54 184.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2MTB6@213481|Bdellovibrionales,2WJQV@28221|Deltaproteobacteria 213481|Bdellovibrionales E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_850317_1 338969.Rfer_0577 2.38e-37 137.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,4A9K8@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_850317_2 338969.Rfer_2901 8.8e-45 162.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,4A9MR@80864|Comamonadaceae 28216|Betaproteobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family arnT - - - - - - - - - - - - k59_494005_1 1169154.KB897781_gene5457 1.13e-22 94.0 COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria 201174|Actinobacteria M aspartate racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_1070479_1 640081.Dsui_1592 1.04e-55 187.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VKV7@28216|Betaproteobacteria,2KV4R@206389|Rhodocyclales 206389|Rhodocyclales CH UbiH UbiF VisC COQ6 family ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_170137_1 929556.Solca_3465 1.2e-102 316.0 COG1132@1|root,COG1132@2|Bacteria,4NEBS@976|Bacteroidetes,1IPPE@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_739540_1 338969.Rfer_1297 2.11e-30 118.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,4AB70@80864|Comamonadaceae 28216|Betaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_739540_2 1286631.X805_16800 2.24e-60 189.0 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,1KKSR@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Nudix hydrolase ntpA - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_99028_1 631362.Thi970DRAFT_04656 1.14e-07 50.1 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria,1WZ82@135613|Chromatiales 135613|Chromatiales K TIGRFAM Addiction module antidote protein, HigA - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_99028_2 365044.Pnap_2637 6.15e-51 179.0 COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria,4AB1K@80864|Comamonadaceae 28216|Betaproteobacteria CK PFAM FMN-binding domain protein - - - ko:K19339 - - - - ko00000,ko03000 - - - FMN_bind,Fer4_10,Fer4_5 k59_134099_1 472759.Nhal_1119 9.01e-30 113.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_1070509_1 640081.Dsui_1630 1.86e-79 244.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KUZH@206389|Rhodocyclales 206389|Rhodocyclales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_170163_1 395019.Bmul_1893 1.35e-97 303.0 COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2VP1K@28216|Betaproteobacteria,1JZQ1@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the TPP enzyme family iolD - 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08603 RC02331 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_918301_1 543728.Vapar_1537 1.88e-71 241.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria,4AGCU@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_390103_1 404380.Gbem_0423 5.38e-11 60.8 COG3224@1|root,COG3224@2|Bacteria,1QUU7@1224|Proteobacteria,43BCJ@68525|delta/epsilon subdivisions,2X6RH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Antibiotic biosynthesis monooxygenase - - - ko:K09932 - - - - ko00000 - - - ABM k59_626579_1 614083.AWQR01000025_gene3661 5.52e-125 358.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHZJ@28216|Betaproteobacteria,4A9YT@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_390113_1 614083.AWQR01000012_gene1350 3.77e-75 237.0 COG1252@1|root,COG1252@2|Bacteria,1QUKT@1224|Proteobacteria,2WGU5@28216|Betaproteobacteria,4ADZF@80864|Comamonadaceae 28216|Betaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1131075_1 1000565.METUNv1_00936 2e-177 504.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2WGNQ@28216|Betaproteobacteria 28216|Betaproteobacteria K Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Sigma54_activat k59_563748_1 1000565.METUNv1_00188 6.27e-90 270.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,2KU6F@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1027923_1 1000565.METUNv1_02600 2.67e-161 467.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VMI4@28216|Betaproteobacteria,2KW0C@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_950741_1 661478.OP10G_2489 2.06e-16 78.2 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1001288_1 1000565.METUNv1_02388 6.32e-211 606.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,2KU6Z@206389|Rhodocyclales 206389|Rhodocyclales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_73011_1 700598.Niako_4541 3.31e-34 134.0 COG4585@1|root,COG4585@2|Bacteria,4NS8E@976|Bacteroidetes 976|Bacteroidetes T Histidine kinase - - 2.7.13.3 ko:K07778 ko02020,map02020 M00479 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3 k59_787618_2 391615.ABSJ01000017_gene1710 1.55e-54 179.0 COG2197@1|root,COG2197@2|Bacteria,1RGXD@1224|Proteobacteria,1S3QG@1236|Gammaproteobacteria,1JA95@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_431144_1 1349767.GJA_2391 3.63e-52 175.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,4729D@75682|Oxalobacteraceae 28216|Betaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_822872_1 1382306.JNIM01000001_gene1786 2.57e-09 63.2 COG1506@1|root,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi 200795|Chloroflexi EU PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_1108311_2 1000565.METUNv1_01440 3.14e-92 276.0 COG0560@1|root,COG0560@2|Bacteria 2|Bacteria E Phosphoserine phosphatase - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD,Hydrolase k59_608219_1 1286631.X805_20060 7.7e-197 573.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KISZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T chemotaxis sensory transducer - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9 k59_572739_1 1000565.METUNv1_00267 1.15e-163 466.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KUX8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S11 family pbp - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_572739_2 1000565.METUNv1_00268 2.99e-152 431.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VNV2@28216|Betaproteobacteria,2KUPV@206389|Rhodocyclales 206389|Rhodocyclales C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG k59_572739_3 1000565.METUNv1_00269 1.44e-15 75.5 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales 206389|Rhodocyclales C Domain of unknown function (DUF3390) - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_287842_1 1000565.METUNv1_00367 3.93e-169 477.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,2KUP3@206389|Rhodocyclales 206389|Rhodocyclales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_502730_2 243159.AFE_1868 0.000413 42.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,2NCNH@225057|Acidithiobacillales 225057|Acidithiobacillales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_215923_1 1000565.METUNv1_01938 3.26e-128 371.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,2KV8N@206389|Rhodocyclales 206389|Rhodocyclales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1037361_1 1198452.Jab_1c24410 5.5e-69 219.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,472IF@75682|Oxalobacteraceae 28216|Betaproteobacteria E Required for the activity of the bacterial periplasmic transport system of putrescine potF - - ko:K11069,ko:K11073 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - SBP_bac_8 k59_1037361_2 743720.Psefu_0367 0.000135 44.7 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1YXSE@136845|Pseudomonas putida group 1236|Gammaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potG GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02052,ko:K11076 ko02010,ko02024,map02010,map02024 M00193,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.2 - iSDY_1059.SDY_0740,iYL1228.KPN_00886 ABC_tran,TOBE_2 k59_679874_1 1000565.METUNv1_00415 4.39e-61 212.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg k59_466063_1 521000.PROVRETT_06008 1.24e-89 301.0 28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,1RQIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_466063_3 1121344.JHZO01000003_gene977 2.95e-112 343.0 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,248E9@186801|Clostridia,3WH9W@541000|Ruminococcaceae 186801|Clostridia S Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_2,Terminase_3,Terminase_3C k59_894529_2 1000565.METUNv1_02045 1.89e-63 207.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales 206389|Rhodocyclales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1073812_1 1000565.METUNv1_02366 6.43e-45 157.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,2KV4V@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1073812_2 1000565.METUNv1_02367 4.3e-62 201.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,2KUQV@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_431171_1 886293.Sinac_3371 2.32e-28 119.0 COG2010@1|root,COG2010@2|Bacteria,2IYIY@203682|Planctomycetes 203682|Planctomycetes C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_359323_1 420662.Mpe_A1957 1.31e-48 164.0 COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2VMQB@28216|Betaproteobacteria,1KJ73@119065|unclassified Burkholderiales 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_359323_2 365044.Pnap_1628 4.13e-21 87.8 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,4AA4Y@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_645437_1 1000565.METUNv1_03297 0.0 1548.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales 206389|Rhodocyclales KNT COG0643 Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_537124_2 1121035.AUCH01000007_gene601 8.33e-17 79.3 COG2346@1|root,COG2346@2|Bacteria,1N1UU@1224|Proteobacteria,2VZUZ@28216|Betaproteobacteria 28216|Betaproteobacteria S COG2346, Truncated hemoglobins - - - - - - - - - - - - - k59_502750_2 1000565.METUNv1_00125 1.87e-80 246.0 28P0I@1|root,2ZBX5@2|Bacteria,1RB8U@1224|Proteobacteria,2VQ6K@28216|Betaproteobacteria,2KW9E@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3025) - - - - - - - - - - - - DUF3025 k59_858317_1 596154.Alide2_3531 3.88e-15 78.2 COG3203@1|root,COG3203@2|Bacteria,1R5T2@1224|Proteobacteria,2VMH6@28216|Betaproteobacteria,4ACZH@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM porin Gram-negative type - - - - - - - - - - - - Porin_4 k59_1108336_1 388399.SSE37_07523 1.52e-48 171.0 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TSTC@28211|Alphaproteobacteria 28211|Alphaproteobacteria CH Catalyzes the formation of catechol from phenol - - 1.14.13.7 ko:K03380 ko00623,ko00627,ko01120,map00623,map00627,map01120 - R00815,R03566 RC00046,RC00236 ko00000,ko00001,ko01000 - - - FAD_binding_3,Phe_hydrox_dim k59_108990_1 1000565.METUNv1_02622 1.59e-104 320.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KV2C@206389|Rhodocyclales 206389|Rhodocyclales NT COG0643 Chemotaxis protein histidine kinase and related kinases - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_608237_1 1000565.METUNv1_02375 1.31e-166 479.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KU63@206389|Rhodocyclales 206389|Rhodocyclales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_144703_1 582744.Msip34_1750 2.67e-77 258.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KKGJ@206350|Nitrosomonadales 206350|Nitrosomonadales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_287862_1 365046.Rta_27720 2.55e-47 176.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,4ACTE@80864|Comamonadaceae 28216|Betaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - HCBP_related,HemolysinCabind k59_431189_2 1346791.M529_10765 4.41e-26 109.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2K25R@204457|Sphingomonadales 204457|Sphingomonadales C aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_2054_2 215803.DB30_6246 4.15e-14 71.6 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,42QW3@68525|delta/epsilon subdivisions,2WNT9@28221|Deltaproteobacteria,2YWWY@29|Myxococcales 28221|Deltaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_181328_2 388413.ALPR1_16229 2.97e-06 53.5 COG3637@1|root,COG3637@2|Bacteria,4NQ11@976|Bacteroidetes,47M42@768503|Cytophagia 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_894553_1 338969.Rfer_3705 2.2e-19 85.5 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,2VN5G@28216|Betaproteobacteria,4ADIY@80864|Comamonadaceae 28216|Betaproteobacteria NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_894553_2 1538295.JY96_06595 8.43e-66 202.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria,1KKZU@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Response regulator receiver cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_324221_1 1000565.METUNv1_03259 1.1e-92 277.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,2VHQA@28216|Betaproteobacteria,2KU9Q@206389|Rhodocyclales 206389|Rhodocyclales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_502763_1 76114.ebA3079 4.03e-67 226.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria,2KV3B@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_502763_2 1000565.METUNv1_00706 8.44e-78 241.0 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria,2KWPG@206389|Rhodocyclales 206389|Rhodocyclales S Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - RecA,SulA k59_1001332_1 1276756.AUEX01000020_gene3412 1.38e-72 233.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,4AC0A@80864|Comamonadaceae 28216|Betaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_73046_1 1267211.KI669560_gene1927 2.31e-43 150.0 2C8ZM@1|root,33PDW@2|Bacteria,4P0QI@976|Bacteroidetes,1IW7S@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_215949_2 614083.AWQR01000009_gene515 1.22e-79 236.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,4AE45@80864|Comamonadaceae 28216|Betaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_109003_1 1000565.METUNv1_03783 1.43e-162 474.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,2VIZD@28216|Betaproteobacteria,2KV0R@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HATPase_c k59_109003_2 1000565.METUNv1_03784 3.97e-15 73.9 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUUN@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1108353_1 391587.KAOT1_19052 1.41e-13 69.3 COG3324@1|root,COG3324@2|Bacteria,4NMFV@976|Bacteroidetes,1I2RH@117743|Flavobacteriia 976|Bacteroidetes S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase k59_858335_1 85643.Tmz1t_3517 6.83e-64 199.0 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2VPZP@28216|Betaproteobacteria,2KW26@206389|Rhodocyclales 206389|Rhodocyclales P iron-storage protein - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_858335_2 565045.NOR51B_1449 5.53e-42 139.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1J6E3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_9 k59_252203_1 1517416.IDAT_00700 4.88e-113 335.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,1RQG2@1236|Gammaproteobacteria,2QF8B@267893|Idiomarinaceae 1236|Gammaproteobacteria C homogentisate 1,2-dioxygenase hmgA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004411,GO:0005488,GO:0005506,GO:0005575,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051213,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_359360_1 1000565.METUNv1_03443 3.68e-72 221.0 COG0662@1|root,COG0662@2|Bacteria,1RHRM@1224|Proteobacteria,2VSY4@28216|Betaproteobacteria,2KX04@206389|Rhodocyclales 206389|Rhodocyclales G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_359360_2 1000565.METUNv1_03442 5.12e-59 203.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,2KUJ2@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1073872_1 1000565.METUNv1_01110 8.25e-194 540.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWRJ@206389|Rhodocyclales 206389|Rhodocyclales T Forkhead associated domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_1073872_2 1000565.METUNv1_01111 1.59e-125 364.0 COG2301@1|root,COG2301@2|Bacteria,1Q91U@1224|Proteobacteria,2VJJY@28216|Betaproteobacteria,2KUFC@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the HpcH HpaI aldolase family citE - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_502781_2 1349767.GJA_886 4.79e-08 56.6 2EJQF@1|root,33DF9@2|Bacteria,1P2QI@1224|Proteobacteria,2W42V@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - VPEP k59_894951_1 1000565.METUNv1_02664 1.95e-217 605.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,2KUYW@206389|Rhodocyclales 206389|Rhodocyclales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_894951_2 1000565.METUNv1_02665 1.27e-142 408.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,2KV5S@206389|Rhodocyclales 206389|Rhodocyclales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_324740_1 1000565.METUNv1_00871 1.85e-122 372.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,2KUS5@206389|Rhodocyclales 206389|Rhodocyclales C nitrite reductase NAD(P)H nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_324740_2 748247.AZKH_0836 3.29e-50 161.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2VSP4@28216|Betaproteobacteria,2KX2K@206389|Rhodocyclales 206389|Rhodocyclales P Rieske-like [2Fe-2S] domain - - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_324740_3 1000565.METUNv1_00869 2.57e-50 170.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,2KUW4@206389|Rhodocyclales 206389|Rhodocyclales P MFS/sugar transport protein narK - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_537451_1 568706.BN118_0866 1.91e-50 164.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,3T2YE@506|Alcaligenaceae 28216|Betaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_537451_2 1000565.METUNv1_03800 1.76e-59 187.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,2KWFM@206389|Rhodocyclales 206389|Rhodocyclales L methyltransferase - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_216286_1 1121035.AUCH01000027_gene3384 8.54e-55 201.0 COG2931@1|root,COG2931@2|Bacteria,1Q12G@1224|Proteobacteria,2W60Q@28216|Betaproteobacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.1.4.50 ko:K01127 ko00563,map00563 - R06623 - ko00000,ko00001,ko01000 - - - Calx-beta,DUF5122,FG-GAP,HemolysinCabind k59_573079_1 1000565.METUNv1_00143 4.58e-142 413.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,2KVHS@206389|Rhodocyclales 206389|Rhodocyclales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_573079_2 1265502.KB905949_gene957 1.29e-65 218.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,4AA27@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_894956_1 1000565.METUNv1_02438 3.82e-62 191.0 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,2KWKQ@206389|Rhodocyclales 206389|Rhodocyclales F phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_894956_2 1000565.METUNv1_02439 4.81e-67 204.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales 206389|Rhodocyclales FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_395386_3 658612.MD26_04780 8.17e-74 232.0 28SNA@1|root,2ZEYI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1001666_1 1123392.AQWL01000010_gene2291 2.99e-15 74.3 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria 28216|Betaproteobacteria U PFAM ABC-1 domain protein - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1001666_2 1123392.AQWL01000010_gene2292 3.1e-92 277.0 2DN0A@1|root,32UPR@2|Bacteria,1N1BR@1224|Proteobacteria,2VVZG@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_680238_1 1504672.669785689 8.64e-110 335.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,4A9RF@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_2409_1 1131269.AQVV01000085_gene1710 1.09e-12 69.7 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - PQQ_2,PQQ_3 k59_788138_1 1112217.PPL19_01210 1.18e-36 135.0 2EZWV@1|root,33T15@2|Bacteria,1NQXM@1224|Proteobacteria,1SK4I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_1037840_1 85643.Tmz1t_0171 1.62e-33 128.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,2VI36@28216|Betaproteobacteria,2KVSH@206389|Rhodocyclales 206389|Rhodocyclales C Isocitrate dehydrogenase icd2 - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1037840_2 1504672.669785428 4.99e-28 114.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,4AAEC@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1006903_1 1041142.ATTP01000010_gene1481 6.28e-32 121.0 COG1216@1|root,COG1216@2|Bacteria,1RAIR@1224|Proteobacteria,2UDYT@28211|Alphaproteobacteria,4BKCI@82115|Rhizobiaceae 28211|Alphaproteobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1006903_2 994573.T472_0210240 5.12e-05 52.4 COG0463@1|root,COG0463@2|Bacteria,1UNFC@1239|Firmicutes,24XAN@186801|Clostridia 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_969342_1 349521.HCH_05484 7.73e-56 175.0 COG1359@1|root,COG1359@2|Bacteria,1MZM5@1224|Proteobacteria 1224|Proteobacteria S (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - - - - - - - - - - - k59_653274_1 1313421.JHBV01000141_gene1065 1.83e-20 95.9 COG3188@1|root,COG3291@1|root,COG3188@2|Bacteria,COG3291@2|Bacteria,4NHVA@976|Bacteroidetes,1IPIV@117747|Sphingobacteriia 976|Bacteroidetes NU oxidoreductase activity - - - - - - - - - - - - PA14 k59_1006919_1 1121898.Q766_08800 7.29e-59 189.0 COG1137@1|root,COG1137@2|Bacteria,4NDUG@976|Bacteroidetes,1HX61@117743|Flavobacteriia,2NU9K@237|Flavobacterium 976|Bacteroidetes S ABC transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_440282_1 395019.Bmul_3681 1.56e-71 226.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,1KGPQ@119060|Burkholderiaceae 28216|Betaproteobacteria G )transporter - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_969876_4 497321.C664_01130 8.91e-56 183.0 2CWYZ@1|root,32T0P@2|Bacteria,1MZEM@1224|Proteobacteria,2VUKY@28216|Betaproteobacteria,2KX31@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_969876_5 637390.AFOH01000040_gene2348 9.67e-219 625.0 COG0270@1|root,COG0270@2|Bacteria,1MV9D@1224|Proteobacteria,1RPD1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_969876_6 243924.LT42_17275 3.37e-139 409.0 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,1RP4Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - ko:K14059 - - - - ko00000 - - - Arm-DNA-bind_2,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_969876_7 522373.Smlt1850 3.56e-40 140.0 28MZ2@1|root,2ZB5W@2|Bacteria,1MZ8Q@1224|Proteobacteria,1SRS5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_969876_8 1552758.NC00_01300 3.23e-74 226.0 COG4678@1|root,COG4678@2|Bacteria,1R92U@1224|Proteobacteria,1S23X@1236|Gammaproteobacteria,1X979@135614|Xanthomonadales 135614|Xanthomonadales G Phage lysozyme - - - - - - - - - - - - Phage_lysozyme k59_969876_12 1005994.GTGU_01416 2.07e-25 116.0 COG5434@1|root,COG5434@2|Bacteria,1RCW1@1224|Proteobacteria,1T1PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Phage_T7_tail k59_969876_13 343509.SG1196 1.71e-211 605.0 COG5410@1|root,COG5410@2|Bacteria,1N0W2@1224|Proteobacteria,1S03G@1236|Gammaproteobacteria 1236|Gammaproteobacteria K chromosome segregation - - - - - - - - - - - - - k59_969876_15 1157708.KB907450_gene5438 2.62e-263 759.0 28IJ1@1|root,2Z8K0@2|Bacteria,1R5PC@1224|Proteobacteria,2W0IK@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_969876_17 1157708.KB907450_gene5436 6.27e-35 145.0 COG0741@1|root,COG0741@2|Bacteria,1PZGG@1224|Proteobacteria,2W3V9@28216|Betaproteobacteria 28216|Betaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_969876_20 343509.SG1191 2.21e-31 117.0 COG1247@1|root,COG1247@2|Bacteria,1RM31@1224|Proteobacteria,1S7YI@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_969876_21 1279038.KB907345_gene3489 5.35e-85 291.0 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_969876_22 1097668.BYI23_B004710 1.8e-51 171.0 2DZ82@1|root,32V6V@2|Bacteria,1N3UK@1224|Proteobacteria,2VY68@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_969876_24 1097668.BYI23_B004690 7.05e-52 179.0 28JRN@1|root,2Z9H7@2|Bacteria,1R9A9@1224|Proteobacteria,2W185@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_969876_25 1005994.GTGU_01427 1.95e-60 201.0 28MND@1|root,2ZAXY@2|Bacteria,1R92K@1224|Proteobacteria,1S1CS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_969876_28 1005994.GTGU_01429 2.17e-192 556.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,1RZ7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_969876_34 1000565.METUNv1_01701 1.41e-85 257.0 2EN9I@1|root,33FXA@2|Bacteria,1NN3A@1224|Proteobacteria,2VXZF@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_969876_35 1000565.METUNv1_01702 1.21e-57 194.0 COG3756@1|root,COG3756@2|Bacteria,1N7P7@1224|Proteobacteria,2VTUI@28216|Betaproteobacteria,2KWQK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_969876_38 580332.Slit_1940 6.42e-22 87.8 COG4197@1|root,COG4197@2|Bacteria,1NHMT@1224|Proteobacteria,2VXKP@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT - - - - - - - - - - - - YdaS_antitoxin k59_969876_39 269482.Bcep1808_1159 1.19e-36 136.0 COG2932@1|root,COG2932@2|Bacteria,1N1RS@1224|Proteobacteria,2WEUP@28216|Betaproteobacteria,1KFX5@119060|Burkholderiaceae 28216|Betaproteobacteria K Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_969876_46 640081.Dsui_0178 1.66e-155 441.0 COG2887@1|root,COG2887@2|Bacteria,1R4U3@1224|Proteobacteria,2VKHK@28216|Betaproteobacteria,2KYVJ@206389|Rhodocyclales 206389|Rhodocyclales L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_969876_47 640081.Dsui_0177 3.22e-126 369.0 28JXH@1|root,2ZA3Z@2|Bacteria,1R8CZ@1224|Proteobacteria,2VMM6@28216|Betaproteobacteria,2KZ12@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_969876_48 1301098.PKB_0742 1.59e-50 171.0 2DMKC@1|root,32S64@2|Bacteria,1N3QF@1224|Proteobacteria,1S8NZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - HNH_3 k59_969876_49 1003200.AXXA_29695 9.8e-10 56.2 2EMS1@1|root,33FEG@2|Bacteria,1NNKZ@1224|Proteobacteria,2W5F0@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1042967_1 1101195.Meth11DRAFT_1461 7.25e-09 55.8 2BUPI@1|root,32Q0I@2|Bacteria,1PJP2@1224|Proteobacteria,2W82W@28216|Betaproteobacteria,2KNJ8@206350|Nitrosomonadales 206350|Nitrosomonadales - - - - - - - - - - - - - - - k59_1042967_2 159087.Daro_1794 7.6e-34 121.0 COG0517@1|root,COG0517@2|Bacteria,1QWGH@1224|Proteobacteria,2WGZ1@28216|Betaproteobacteria,2KZQ2@206389|Rhodocyclales 206389|Rhodocyclales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_755753_1 1237149.C900_01627 7.81e-38 144.0 COG4775@1|root,COG4775@2|Bacteria,4NF9Y@976|Bacteroidetes,47KUK@768503|Cytophagia 976|Bacteroidetes M PFAM surface antigen variable number repeat - - - - - - - - - - - - Bac_surface_Ag,POTRA k59_793429_1 1000565.METUNv1_00743 2.39e-09 53.9 COG2944@1|root,COG2944@2|Bacteria,1N48U@1224|Proteobacteria,2VUHQ@28216|Betaproteobacteria,2KWYQ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 k59_440329_1 1000565.METUNv1_02523 4.14e-140 403.0 COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,2KW5M@206389|Rhodocyclales 206389|Rhodocyclales P Transcriptional regulator of molybdate metabolism, LysR family protein - - - - - - - - - - - - HTH_1,PBP_like k59_219409_2 59538.XP_005971648.1 4e-35 132.0 COG0516@1|root,KOG2550@2759|Eukaryota,38FT7@33154|Opisthokonta,3BAKM@33208|Metazoa,3CZ6R@33213|Bilateria,47ZBY@7711|Chordata,48YPE@7742|Vertebrata,3J810@40674|Mammalia,4J8SD@91561|Cetartiodactyla 33208|Metazoa F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors - - - - - - - - - - - - CBS,IMPDH k59_365299_1 640511.BC1002_5089 3.23e-39 142.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VVIX@28216|Betaproteobacteria,1K0FV@119060|Burkholderiaceae 28216|Betaproteobacteria T Diguanylate cyclase with PAS PAC sensor - - - - - - - - - - - - GGDEF,PAS,PAS_4 k59_1083007_1 398578.Daci_1946 3.77e-20 87.4 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2W259@28216|Betaproteobacteria 28216|Betaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_1083007_2 398578.Daci_1945 8.34e-32 120.0 2DTUK@1|root,33MQ2@2|Bacteria,1NPI3@1224|Proteobacteria,2W420@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_541827_1 1123399.AQVE01000011_gene1245 2.16e-25 106.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RQ1V@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the IUNH family - - - - - - - - - - - - IU_nuc_hydro k59_1042986_1 1000565.METUNv1_04023 1.95e-183 520.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VJK2@28216|Betaproteobacteria,2KUNA@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_684461_1 216142.LT40_17820 1.39e-75 249.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Acyltransferase - - - - - - - - - - - - Acyl_transf_3 k59_684461_2 983917.RGE_04280 5.89e-26 107.0 COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,2VTMV@28216|Betaproteobacteria,1KNC3@119065|unclassified Burkholderiales 28216|Betaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_332827_2 1000565.METUNv1_03772 8.94e-41 142.0 COG1216@1|root,COG1216@2|Bacteria,1R1SJ@1224|Proteobacteria 1224|Proteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - - k59_829438_1 113395.AXAI01000001_gene3389 8.03e-83 250.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,3JTSH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_440393_1 1122951.ATUE01000008_gene35 7.3e-116 355.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,3NM2Z@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_1083065_1 1249627.D779_2014 9.9e-48 162.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_365337_2 1000565.METUNv1_00567 3.77e-61 189.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VSQE@28216|Betaproteobacteria,2KWP0@206389|Rhodocyclales 206389|Rhodocyclales C Ferredoxin, 2Fe-2S type, ISC system - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_219425_1 887062.HGR_12052 4.3e-17 80.1 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,4AA3F@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_219425_2 614083.AWQR01000009_gene579 2.93e-144 416.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria 1224|Proteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - - - - - - - - - - - Peptidase_M19 k59_654717_1 1278073.MYSTI_05966 1.65e-46 164.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_114011_1 1123367.C666_18345 1.07e-22 96.3 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KUAS@206389|Rhodocyclales 206389|Rhodocyclales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_654718_1 1304883.KI912532_gene1694 2.73e-73 234.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,2KZZK@206389|Rhodocyclales 206389|Rhodocyclales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_684490_1 1000565.METUNv1_03066 9.39e-97 295.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KV06@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_294446_1 1286106.MPL1_10803 6.34e-73 239.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,45ZS9@72273|Thiotrichales 72273|Thiotrichales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_541858_1 62928.azo3438 8.21e-38 145.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - DUF2222,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_541858_2 999541.bgla_1g09870 5.57e-37 125.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria,1K8BW@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_541858_3 1000565.METUNv1_02491 1.88e-88 263.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,2KWFJ@206389|Rhodocyclales 206389|Rhodocyclales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_190218_1 521674.Plim_2734 1.87e-24 107.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,2IWZR@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1112629_1 582744.Msip34_0008 5.86e-12 66.6 2DP14@1|root,3303I@2|Bacteria,1N7JW@1224|Proteobacteria,2VW7N@28216|Betaproteobacteria,2KN9U@206350|Nitrosomonadales 206350|Nitrosomonadales - - - - - - - - - - - - - - - k59_1112629_2 1000565.METUNv1_02675 2.1e-17 80.5 2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,2VSJ5@28216|Betaproteobacteria,2KWQC@206389|Rhodocyclales 206389|Rhodocyclales S Glycine-zipper domain - - - - - - - - - - - - Gly-zipper_OmpA,Gly-zipper_YMGG k59_691173_1 1159870.KB907784_gene2630 1.38e-77 243.0 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,3T2QH@506|Alcaligenaceae 28216|Betaproteobacteria E Glycine D-amino acid oxidases (deaminating) - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_157477_1 1198452.Jab_1c19940 3.68e-107 315.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,47366@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_691184_1 322710.Avin_44260 2.57e-65 207.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity JD73_00815 - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1051001_1 1201288.M900_0222 1.33e-84 262.0 2BKCR@1|root,32ETA@2|Bacteria,1RJ21@1224|Proteobacteria,430EX@68525|delta/epsilon subdivisions,2MT09@213481|Bdellovibrionales,2WVVF@28221|Deltaproteobacteria 213481|Bdellovibrionales - - - - - - - - - - - - - - - k59_265538_2 1000565.METUNv1_02473 4.57e-81 242.0 COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,2KWXJ@206389|Rhodocyclales 206389|Rhodocyclales S membrane protein domain - - - - - - - - - - - - RDD k59_302423_1 886379.AEWI01000012_gene1168 6.54e-53 188.0 COG0038@1|root,COG0038@2|Bacteria,4NZYS@976|Bacteroidetes,2G0DB@200643|Bacteroidia,3XJ2T@558415|Marinilabiliaceae 976|Bacteroidetes P Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_85757_1 1095769.CAHF01000013_gene3190 2.82e-45 152.0 COG3456@1|root,COG3456@2|Bacteria,1QWSG@1224|Proteobacteria,2WI9Y@28216|Betaproteobacteria 28216|Betaproteobacteria T conserved protein contains FHA domain - - - - - - - - - - - - - k59_85757_2 1219031.BBJR01000050_gene1614 4.95e-06 48.9 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,4A9Q3@80864|Comamonadaceae 28216|Betaproteobacteria T protein phosphatase 2C domain protein pphA - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_582920_1 375286.mma_2361 4.86e-42 167.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VHH4@28216|Betaproteobacteria 28216|Betaproteobacteria U COG3210 Large exoproteins involved in heme utilization or adhesion - - - - - - - - - - - - DUF3739,ESPR,Haemagg_act k59_85760_1 927658.AJUM01000022_gene1140 4.09e-09 63.2 COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes,2FMYC@200643|Bacteroidia,3XKHF@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolases family 28 - - - - - - - - - - - - Glyco_hydro_28,Glyco_hydro_88,Pectate_lyase_3 k59_452176_1 546267.NEIPOLOT_00440 3.12e-09 54.7 COG5005@1|root,COG5005@2|Bacteria 2|Bacteria S Phage virion morphogenesis - - - - - - - - - - - - Phage_tail_S k59_761840_1 365044.Pnap_1721 2.59e-67 218.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,4AAW6@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_582930_1 614083.AWQR01000020_gene176 5.8e-96 286.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,4A9TM@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_761843_1 1000565.METUNv1_03764 8.08e-25 102.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,2KVCF@206389|Rhodocyclales 206389|Rhodocyclales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_1014383_1 1276756.AUEX01000024_gene60 1.61e-117 372.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,4ABRN@80864|Comamonadaceae 28216|Betaproteobacteria E glutamate synthase, alpha subunit domain protein gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_617165_4 439235.Dalk_4583 2.89e-15 72.8 2EI48@1|root,33BVK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_801367_1 497321.C664_11455 2.68e-136 399.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,2KV1Y@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_940241_1 1121035.AUCH01000020_gene2632 3.43e-82 261.0 COG0028@1|root,COG0028@2|Bacteria,1MYUS@1224|Proteobacteria,2VM1Y@28216|Betaproteobacteria,2KU67@206389|Rhodocyclales 206389|Rhodocyclales EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_549208_1 1121904.ARBP01000002_gene6718 6.34e-28 110.0 COG2242@1|root,COG2242@2|Bacteria,4NV0U@976|Bacteroidetes,47UY2@768503|Cytophagia 976|Bacteroidetes H Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_157537_1 1469607.KK073769_gene5796 6.06e-37 143.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1GC4I@1117|Cyanobacteria,1HR9F@1161|Nostocales 1117|Cyanobacteria KLT Protein kinase G tetratricopeptide repeat - - 2.7.11.1 ko:K14949 ko05152,map05152 - - - ko00000,ko00001,ko01000,ko01001 - - - Pkinase,PknG_TPR,PknG_rubred k59_85812_1 1123248.KB893381_gene1014 1.67e-27 115.0 COG0457@1|root,COG0457@2|Bacteria,4NIEU@976|Bacteroidetes,1IPR2@117747|Sphingobacteriia 976|Bacteroidetes NU PFAM Tetratricopeptide - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_761877_1 397945.Aave_3696 4.33e-98 287.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,4AAIY@80864|Comamonadaceae 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_761883_2 563192.HMPREF0179_00180 3.74e-62 209.0 2DBB8@1|root,2Z867@2|Bacteria,1NDFK@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3383) - - - - - - - - - - - - DUF3383 k59_907319_1 887062.HGR_06636 1.53e-103 318.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_1051166_1 491205.JARQ01000003_gene2087 7.84e-11 68.2 COG2374@1|root,COG4932@1|root,COG2374@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein XK27_02140 - - ko:K07004 - - - - ko00000 - - - 5_nucleotid_C,CHB_HEX_C_1,Calx-beta,Exo_endo_phos,Gram_pos_anchor,HemolysinCabind,LTD,Metallophos,SLH k59_940273_1 614083.AWQR01000002_gene2982 5.75e-79 252.0 COG0624@1|root,COG3195@1|root,COG0624@2|Bacteria,COG3195@2|Bacteria,1MVUX@1224|Proteobacteria,2VIGB@28216|Betaproteobacteria,4AB68@80864|Comamonadaceae 28216|Betaproteobacteria E Amidase, hydantoinase carbamoylase family uraD - 3.5.1.6,3.5.1.87,3.5.3.9 ko:K02083,ko:K06016 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00046 R00905,R02423,R04666 RC00064,RC00096 ko00000,ko00001,ko00002,ko01000,ko01002 - - - M20_dimer,OHCU_decarbox,Peptidase_M20,Peptidase_M28 k59_940274_1 1198452.Jab_2c30360 6.21e-92 285.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,472R0@75682|Oxalobacteraceae 28216|Betaproteobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family arnT - - - - - - - - - - - - k59_1051178_1 1353276.JADR01000006_gene1220 2.14e-38 142.0 COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,4P5EA@976|Bacteroidetes,1IJ7J@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,PAS_3,PAS_9 k59_201759_1 1502852.FG94_03900 5.06e-54 186.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,473JC@75682|Oxalobacteraceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_201763_1 159087.Daro_3133 2.79e-14 70.9 COG3258@1|root,COG4654@1|root,COG3258@2|Bacteria,COG4654@2|Bacteria,1QTYW@1224|Proteobacteria,2VIQV@28216|Betaproteobacteria,2KV9A@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_201763_2 159087.Daro_3132 7.26e-69 211.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,2KWNG@206389|Rhodocyclales 206389|Rhodocyclales S Sulfur oxidation protein SoxY soxY - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_802681_2 339670.Bamb_4737 1.83e-45 155.0 COG1309@1|root,COG1309@2|Bacteria,1N1Q3@1224|Proteobacteria,2VQ9Q@28216|Betaproteobacteria,1K9V8@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_N k59_266939_1 981223.AIED01000028_gene379 1.92e-102 313.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,3NIS9@468|Moraxellaceae 1236|Gammaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009987,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019058,GO:0019068,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0044183,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0097159,GO:0097367,GO:0101031,GO:1901265,GO:1901363,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_762928_1 1122951.ATUE01000006_gene1287 3.61e-17 74.3 COG0695@1|root,COG0695@2|Bacteria 2|Bacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins XAC3035 - - ko:K06191 - - - - ko00000 - - - DUF836,Glutaredoxin k59_762928_2 1182590.BN5_01710 9.42e-40 140.0 COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,1YDFH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L TatD related DNase tatD GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1053101_1 608538.HTH_0152 1.62e-06 56.2 COG0843@1|root,COG0843@2|Bacteria 2|Bacteria C heme-copper terminal oxidase activity - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_15671_1 82995.CR62_16655 2.97e-91 283.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,1RS66@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Participates in initiation and elongation during chromosome replication - - - - - - - - - - - - - k59_52041_1 1000565.METUNv1_01236 3.37e-44 154.0 COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,2KW5M@206389|Rhodocyclales 28216|Betaproteobacteria P Transcriptional regulator of molybdate metabolism, LysR family protein - - - - - - - - - - - - HTH_1,PBP_like k59_52041_2 1000565.METUNv1_01017 2e-71 225.0 COG3284@1|root,COG3284@2|Bacteria,1R9CQ@1224|Proteobacteria 1224|Proteobacteria KQ Transcriptional regulator - - - - - - - - - - - - - k59_1015585_1 883126.HMPREF9710_00534 2.1e-82 251.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,473FX@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_762929_1 929558.SMGD1_1761 3.73e-11 67.4 COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42UYY@68525|delta/epsilon subdivisions 1224|Proteobacteria PT Diguanylate cyclase, possibly nitrate nitrite or cation sensing (GGDEF HAMP linker domain, Hemerythrin HHE domain) - - 2.7.7.65 ko:K21088 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - GGDEF,Hemerythrin,NIT,PilJ,dCache_3 k59_583986_1 1064535.MELS_1091 6.91e-49 181.0 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,4H2HP@909932|Negativicutes 909932|Negativicutes S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_15679_1 1000565.METUNv1_00757 2.57e-30 113.0 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,2KWT1@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - - - - - - - - - - TPR_21 k59_15679_2 1000565.METUNv1_00758 9.27e-98 296.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,2KVKZ@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_550670_1 1122951.ATUE01000006_gene1497 2.03e-136 394.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,3NK7D@468|Moraxellaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadA GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2612,iECNA114_1301.ECNA114_4154,iECOK1_1307.ECOK1_4314,iECP_1309.ECP_4058,iECS88_1305.ECS88_4293,iECSF_1327.ECSF_3702,iEcE24377_1341.EcE24377A_4364,iLF82_1304.LF82_0613,iNRG857_1313.NRG857_19195,iPC815.YPO3767 Thiolase_C,Thiolase_N k59_15684_1 1088721.NSU_0767 7.66e-13 74.3 2EG1N@1|root,339TN@2|Bacteria,1NEFY@1224|Proteobacteria,2UGTQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S prophage protein Bartonella henselae str. Houston-1 gi 49237922 emb CAF27125.1 - - - - - - - - - - - - - k59_550678_1 399795.CtesDRAFT_PD5115 6.21e-55 177.0 COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2VJDD@28216|Betaproteobacteria,4ACUF@80864|Comamonadaceae 28216|Betaproteobacteria P Membrane protein TerC - - - - - - - - - - - - TerC k59_908400_1 1095769.CAHF01000025_gene658 3.98e-74 227.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2VK5E@28216|Betaproteobacteria,4747A@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_266978_1 887062.HGR_00799 9.2e-98 310.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,dCache_1 k59_266982_1 1286632.P278_25370 1.51e-40 146.0 COG1853@1|root,COG1853@2|Bacteria,4NF4H@976|Bacteroidetes,1HWZA@117743|Flavobacteriia 976|Bacteroidetes S Conserved protein domain typically associated with flavoprotein - - - - - - - - - - - - Flavin_Reduct k59_480749_2 1000565.METUNv1_02443 1.61e-187 529.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,2KV5H@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the peptidase S1C family - - - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_226494_1 29581.BW37_04067 5.79e-72 230.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,472A6@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_226494_2 1198452.Jab_2c03420 1.03e-07 52.4 COG0637@1|root,COG0637@2|Bacteria,1MX3R@1224|Proteobacteria,2WGNJ@28216|Betaproteobacteria,475HR@75682|Oxalobacteraceae 28216|Betaproteobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_480774_1 87626.PTD2_11784 0.000666 44.7 COG5662@1|root,COG5662@2|Bacteria,1RJ4M@1224|Proteobacteria,1S23M@1236|Gammaproteobacteria,2Q1EH@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Protein of unknown function (DUF3379) EBIG1770 - - - - - - - - - - - DUF3379 k59_480774_2 1000565.METUNv1_00113 8.21e-39 133.0 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE8 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_203617_1 243090.RB3373 0.000256 45.1 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,2J1U9@203682|Planctomycetes 203682|Planctomycetes T AAA ATPase domain - - 2.7.13.3 ko:K02486 - - - - ko00000,ko01000,ko01001,ko02022 - - - AAA_16,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_346548_1 614083.AWQR01000030_gene2756 2.16e-23 93.2 COG3265@1|root,COG3265@2|Bacteria,1RHD0@1224|Proteobacteria,2VSY0@28216|Betaproteobacteria,4AEM1@80864|Comamonadaceae 28216|Betaproteobacteria F TIGRFAM Carbohydrate kinase, thermoresistant glucokinase idnK - 2.7.1.12 ko:K00851 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 - R01737 RC00002,RC00017 ko00000,ko00001,ko01000 - - - AAA_33,SKI k59_346548_2 1286631.X805_25020 1.05e-24 101.0 COG1609@1|root,COG1609@2|Bacteria,1MUEP@1224|Proteobacteria,2VKIB@28216|Betaproteobacteria,1KJCF@119065|unclassified Burkholderiales 28216|Betaproteobacteria K helix_turn _helix lactose operon repressor gntR - - ko:K06145 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_1053213_1 1242864.D187_001888 3.15e-76 240.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,438FH@68525|delta/epsilon subdivisions,2X3QH@28221|Deltaproteobacteria,2YWUI@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the xylose isomerase family xylA - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_122655_1 1123253.AUBD01000001_gene1501 2.46e-44 150.0 COG1100@1|root,COG1100@2|Bacteria,1N5QS@1224|Proteobacteria,1RRJ1@1236|Gammaproteobacteria,1X3WC@135614|Xanthomonadales 135614|Xanthomonadales S AAA domain - - - - - - - - - - - - AAA_24 k59_122655_2 795666.MW7_1082 3.36e-72 223.0 COG3617@1|root,COG3617@2|Bacteria,1N09A@1224|Proteobacteria,2VWEW@28216|Betaproteobacteria,1KAYV@119060|Burkholderiaceae 28216|Betaproteobacteria K Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Bro-N,ORF6C k59_1015672_1 395495.Lcho_2219 1.16e-19 82.4 COG4190@1|root,COG4190@2|Bacteria,1RKR6@1224|Proteobacteria,2VWG1@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_1015672_2 1265502.KB905950_gene889 1.58e-16 72.4 2DAFR@1|root,32TVC@2|Bacteria,1R3F7@1224|Proteobacteria,2WIHA@28216|Betaproteobacteria 28216|Betaproteobacteria S ParD-like antitoxin of type II bacterial toxin-antitoxin system - - - - - - - - - - - - ParD_like k59_668761_2 443143.GM18_3355 5.23e-35 138.0 COG3267@1|root,COG3267@2|Bacteria,1PZNE@1224|Proteobacteria,42STP@68525|delta/epsilon subdivisions,2WP32@28221|Deltaproteobacteria 28221|Deltaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_941308_2 316067.Geob_2130 8.39e-28 112.0 COG0463@1|root,COG0463@2|Bacteria,1RF0J@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase family 2 - - 2.4.1.60 ko:K13005 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_2 k59_584059_1 1198452.Jab_1c11860 1.13e-57 180.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,47450@75682|Oxalobacteraceae 28216|Betaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1091489_1 358220.C380_20180 2.05e-31 124.0 COG0811@1|root,COG1196@1|root,COG0811@2|Bacteria,COG1196@2|Bacteria,1QVYF@1224|Proteobacteria,2VH31@28216|Betaproteobacteria,4AJYP@80864|Comamonadaceae 28216|Betaproteobacteria D Domain of unknown function (DUF802) - - - - - - - - - - - - DUF802 k59_1091489_2 296591.Bpro_0505 4.28e-39 136.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2VJJE@28216|Betaproteobacteria,4ADKF@80864|Comamonadaceae 28216|Betaproteobacteria N OmpA family yiaD_2 - - - - - - - - - - - OmpA k59_1015677_2 1026882.MAMP_01578 2.77e-57 204.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,461X9@72273|Thiotrichales 72273|Thiotrichales NU Type IV fimbrial biogenesis protein PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_525445_1 93220.LV28_06630 1.55e-95 288.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1JZSY@119060|Burkholderiaceae 28216|Betaproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_550779_1 349521.HCH_06112 2.65e-117 340.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1XI2U@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_978040_1 1279017.AQYJ01000024_gene1172 8.39e-55 193.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,465IY@72275|Alteromonadaceae 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_908464_1 1163407.UU7_01137 6.62e-73 232.0 COG0399@1|root,COG0399@2|Bacteria,1QTGA@1224|Proteobacteria,1S1EX@1236|Gammaproteobacteria,1X5GY@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_63780_1 42099.EPrPV00000024807 4.17e-31 119.0 2990X@1|root,2RG2A@2759|Eukaryota,1MK3J@121069|Pythiales 42099.EPrPV00000024807|- - - - - - - - - - - - - - - - k59_495122_2 1000565.METUNv1_00288 1.36e-98 288.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,2KW34@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_740554_1 1123367.C666_00920 5.97e-85 261.0 COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2VH92@28216|Betaproteobacteria,2KUZ0@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system cysA - 3.6.3.25 ko:K02045 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.1,3.A.1.6.3 - - ABC_tran,TOBE_3 k59_1099066_1 1122951.ATUE01000005_gene1786 7.86e-113 337.0 COG0403@1|root,COG0403@2|Bacteria,1QXPU@1224|Proteobacteria,1T3FD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glycine dehydrogenase - - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_951358_2 1353529.M899_0145 4.92e-41 152.0 COG2911@1|root,COG2911@2|Bacteria,1PQTA@1224|Proteobacteria,42PYT@68525|delta/epsilon subdivisions,2MT6E@213481|Bdellovibrionales,2WIZ6@28221|Deltaproteobacteria 213481|Bdellovibrionales M TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_391421_1 1282360.ABAC460_19745 1.75e-11 66.2 COG3534@1|root,COG3534@2|Bacteria 2|Bacteria G alpha-L-arabinofuranosidase - - - - - - - - - - - - Glyco_hydro_43,Laminin_G_3 k59_391421_2 639030.JHVA01000001_gene1924 1.53e-10 66.2 COG3118@1|root,COG3118@2|Bacteria,3Y69N@57723|Acidobacteria,2JMI3@204432|Acidobacteriia 204432|Acidobacteriia O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_1028896_1 1304883.KI912532_gene2084 1.51e-96 305.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,2KV6D@206389|Rhodocyclales 206389|Rhodocyclales I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_134952_1 1116472.MGMO_126c00070 2.7e-17 78.2 2C84F@1|root,334ZR@2|Bacteria,1N6VS@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_134952_2 338969.Rfer_1080 1.01e-37 134.0 COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,2VM56@28216|Betaproteobacteria,4ACXJ@80864|Comamonadaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - ko:K15268 - - - - ko00000,ko02000 2.A.7.3.2 - - EamA k59_564611_1 1453498.LG45_06830 1.02e-58 195.0 COG2377@1|root,COG2377@2|Bacteria,4NFZU@976|Bacteroidetes,1HWX7@117743|Flavobacteriia,2NTIS@237|Flavobacterium 976|Bacteroidetes O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_319183_1 1276756.AUEX01000005_gene2860 9.36e-148 441.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,4AA3D@80864|Comamonadaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_171186_1 1349767.GJA_5233 1.73e-55 195.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,4791Y@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - 4HB_MCP_1,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg k59_951397_2 261292.Nit79A3_0994 1.22e-82 253.0 COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,372C9@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component cysT - - ko:K02046,ko:K15496 ko00920,ko02010,map00920,map02010 M00185,M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.6.5 - - BPD_transp_1 k59_1132012_1 69395.JQLZ01000002_gene1367 1.55e-86 269.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2KFBR@204458|Caulobacterales 204458|Caulobacterales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1028956_1 946483.Cenrod_1793 5.4e-53 188.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,HAMP,MCPsignal,TarH k59_851487_1 1223521.BBJX01000020_gene2945 8.93e-83 268.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,4AAPA@80864|Comamonadaceae 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_627230_2 338969.Rfer_1563 1.06e-77 243.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,4AC62@80864|Comamonadaceae 28216|Betaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_564662_1 1121935.AQXX01000079_gene1546 5.43e-38 139.0 COG3464@1|root,COG3464@2|Bacteria,1R97S@1224|Proteobacteria,1RRBR@1236|Gammaproteobacteria 1236|Gammaproteobacteria L TrfA protein - - - - - - - - - - - - TrfA k59_100099_2 1123256.KB907943_gene459 1.11e-18 85.5 COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T2N9@1236|Gammaproteobacteria,1XDFX@135614|Xanthomonadales 135614|Xanthomonadales T PAS fold - - - - - - - - - - - - GGDEF k59_418739_1 663610.JQKO01000016_gene1590 9.96e-23 100.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,3NBJ5@45404|Beijerinckiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1,Sugar_tr k59_1028977_1 452637.Oter_1491 1.1e-44 159.0 COG3014@1|root,COG3014@2|Bacteria 2|Bacteria S protein conserved in bacteria - - - - - - - - - - - - PMT_2 k59_319244_1 1268622.AVS7_03426 5.17e-35 134.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHCY@28216|Betaproteobacteria,4ABPM@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9 k59_319244_2 748247.AZKH_0832 0.000188 43.9 COG4564@1|root,COG4564@2|Bacteria,1RBG4@1224|Proteobacteria,2VRWI@28216|Betaproteobacteria 28216|Betaproteobacteria T COG0840 Methyl-accepting chemotaxis protein - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - sCache_2 k59_100132_1 381666.H16_B0328 4.25e-64 211.0 2BV0W@1|root,32QDG@2|Bacteria,1PK4B@1224|Proteobacteria,2W2N8@28216|Betaproteobacteria,1KDPQ@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_919195_1 399795.CtesDRAFT_PD2831 9.51e-25 110.0 COG2199@1|root,COG2199@2|Bacteria,1RE33@1224|Proteobacteria,2VRWV@28216|Betaproteobacteria,4AE1D@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,dCache_1 k59_851543_1 338969.Rfer_2580 1.63e-105 317.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,4A9KD@80864|Comamonadaceae 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_740728_1 1131814.JAFO01000001_gene3555 2.69e-68 214.0 COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2U59W@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Nitroreductase pnbA - - - - - - - - - - - Nitroreductase k59_886998_1 68199.JNZO01000026_gene5724 2.01e-11 69.7 COG1403@1|root,COG1403@2|Bacteria,2I9UA@201174|Actinobacteria 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - - k59_627264_1 1415780.JPOG01000001_gene2332 1.32e-81 254.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1X38D@135614|Xanthomonadales 135614|Xanthomonadales M synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1099171_1 1348338.ADILRU_0575 5.24e-05 51.2 COG2197@1|root,COG2197@2|Bacteria,2GXUH@201174|Actinobacteria,4FQHW@85023|Microbacteriaceae 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_319296_1 1348657.M622_18765 1.39e-18 82.0 COG2703@1|root,COG2703@2|Bacteria,1MZJ3@1224|Proteobacteria,2VVGT@28216|Betaproteobacteria 28216|Betaproteobacteria P PFAM Hemerythrin HHE cation binding domain protein - - - - - - - - - - - - - k59_236741_1 614083.AWQR01000022_gene84 1.4e-95 297.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,4AA2X@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ABC transporter related uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_391681_1 1267211.KI669560_gene997 3.22e-80 245.0 COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,1IPF1@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_1132118_1 1452718.JBOY01000052_gene1211 4.7e-25 108.0 COG2199@1|root,COG3706@2|Bacteria,1MZQ8@1224|Proteobacteria,1RS4B@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase yneF - 2.7.7.65 ko:K21020 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GGDEF,MASE1 k59_63979_1 748247.AZKH_1699 1.43e-64 220.0 COG3598@1|root,COG4643@1|root,COG3598@2|Bacteria,COG4643@2|Bacteria,1R4EA@1224|Proteobacteria,2VKG4@28216|Betaproteobacteria,2KWQR@206389|Rhodocyclales 206389|Rhodocyclales L AAA domain - - - - - - - - - - - - AAA_25,PriCT_2 k59_1029094_2 287.DR97_5244 2.88e-67 204.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1YG9S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_9 k59_495401_1 1268622.AVS7_03997 2.57e-24 98.2 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,4AAN8@80864|Comamonadaceae 28216|Betaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_495401_2 338969.Rfer_2781 2.88e-54 177.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,4AACE@80864|Comamonadaceae 28216|Betaproteobacteria O protein-L-isoaspartate O-methyltransferase pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_564783_1 1123253.AUBD01000001_gene1471 3.16e-44 164.0 COG5281@1|root,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1S3MM@1236|Gammaproteobacteria,1XC2I@135614|Xanthomonadales 135614|Xanthomonadales D tape measure protein - - - - - - - - - - - - - k59_991783_1 497321.C664_12140 1.68e-80 270.0 COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,2KVVR@206389|Rhodocyclales 206389|Rhodocyclales M COG0744 Membrane carboxypeptidase (penicillin-binding protein) - - - - - - - - - - - - Transgly,Transpeptidase k59_281740_1 1349767.GJA_4787 8.43e-86 266.0 2CG46@1|root,2Z7W3@2|Bacteria,1NFW3@1224|Proteobacteria,2VN3X@28216|Betaproteobacteria,4769H@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_65951_1 159087.Daro_1701 2.2e-11 59.7 2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,2VVSC@28216|Betaproteobacteria,2KX6Q@206389|Rhodocyclales 206389|Rhodocyclales S Coenzyme PQQ synthesis protein D (PqqD) pqqD - - ko:K06138 - - - - ko00000 - - - PqqD k59_65951_2 159087.Daro_1700 3.84e-160 449.0 COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2VI0X@28216|Betaproteobacteria,2KUDW@206389|Rhodocyclales 206389|Rhodocyclales H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_65951_3 472759.Nhal_3510 0.000157 43.1 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,1RMM9@1236|Gammaproteobacteria,1WY17@135613|Chromatiales 135613|Chromatiales H May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_136929_1 1268622.AVS7_02506 9.26e-101 305.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,4AA4J@80864|Comamonadaceae 28216|Betaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport nrtA - - ko:K02051,ko:K15576 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - NMT1_2 k59_743425_1 305700.B447_13379 6.46e-32 121.0 2DB9W@1|root,2Z7Z9@2|Bacteria,1MZFV@1224|Proteobacteria,2VHWP@28216|Betaproteobacteria,2KVEW@206389|Rhodocyclales 206389|Rhodocyclales C Methane/Phenol/Toluene Hydroxylase - - - ko:K16243 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002 - - - Phenol_Hydrox k59_743425_2 292.DM42_5001 4.21e-29 106.0 2CJVU@1|root,32S7J@2|Bacteria,1N03Q@1224|Proteobacteria,2VUNQ@28216|Betaproteobacteria,1K9D4@119060|Burkholderiaceae 28216|Betaproteobacteria C MmoB/DmpM family - - - ko:K16244 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002 - - - MmoB_DmpM k59_743425_3 305700.B447_13369 8.51e-58 192.0 COG3350@1|root,COG3350@2|Bacteria,1MWWK@1224|Proteobacteria,2VH88@28216|Betaproteobacteria,2KUMX@206389|Rhodocyclales 206389|Rhodocyclales S YHS domain - - - ko:K16242 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002,ko01000 - - - Phenol_Hydrox,YHS k59_953168_1 365044.Pnap_1076 1.67e-77 241.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,4A9YA@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red k59_953168_2 543728.Vapar_3773 1.24e-09 56.2 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,4ABKA@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ebsC - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_596260_1 929562.Emtol_2849 1.24e-70 238.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47K8C@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_921127_1 1408813.AYMG01000013_gene1169 5.48e-125 363.0 COG3507@1|root,COG3507@2|Bacteria,4NDUM@976|Bacteroidetes,1IS1C@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_498025_1 614083.AWQR01000014_gene2443 1.16e-87 285.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4A9T5@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_136940_2 580332.Slit_2498 8.54e-43 143.0 COG4654@1|root,COG4654@2|Bacteria,1MZJM@1224|Proteobacteria,2VV99@28216|Betaproteobacteria,44WKN@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM cytochrome c class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_281783_1 319225.Plut_1023 3.63e-27 101.0 COG0724@1|root,COG0724@2|Bacteria,1FE64@1090|Chlorobi 1090|Chlorobi S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_29682_1 700598.Niako_4404 9.79e-97 311.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1INN6@117747|Sphingobacteriia 976|Bacteroidetes P TonB-dependent receptor plug domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_65988_1 1000565.METUNv1_01290 3.75e-48 166.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,2KVNR@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_953206_1 338969.Rfer_0297 9.2e-44 154.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2VKP6@28216|Betaproteobacteria,4AE1J@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, arabinose operon control protein - - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_628686_1 614083.AWQR01000005_gene1088 9.47e-80 246.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,4AA08@80864|Comamonadaceae 28216|Betaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_2 k59_854053_1 29581.BW37_00724 3.18e-77 256.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,473MX@75682|Oxalobacteraceae 28216|Betaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_863059_1 765911.Thivi_1009 4.95e-12 67.0 COG0642@1|root,COG0745@1|root,COG2198@1|root,COG3829@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,COG3829@2|Bacteria,1NWAF@1224|Proteobacteria,1SRJQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - EAL,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_863059_2 338969.Rfer_4055 1.45e-14 75.1 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4AD7J@80864|Comamonadaceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9,dCache_1 k59_79206_1 1000565.METUNv1_00822 5.48e-212 597.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,2KUQ9@206389|Rhodocyclales 206389|Rhodocyclales FP Exopolyphosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_79206_2 1000565.METUNv1_00823 1.3e-168 482.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria,2KUN0@206389|Rhodocyclales 206389|Rhodocyclales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_79206_3 1000565.METUNv1_00824 1.18e-134 385.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJK6@28216|Betaproteobacteria,2KVH1@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_400698_1 296591.Bpro_3277 4.46e-17 79.3 COG3850@1|root,COG3850@2|Bacteria,1N23T@1224|Proteobacteria,2VQFG@28216|Betaproteobacteria,4AJST@80864|Comamonadaceae 28216|Betaproteobacteria T Type IV pili methyl-accepting chemotaxis transducer N-term - - - - - - - - - - - - PilJ k59_400698_2 1286631.X805_40060 1.63e-40 149.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KIU4@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_219308_1 1226994.AMZB01000059_gene3628 1.37e-20 86.7 2BA7A@1|root,33YWN@2|Bacteria,1NYYV@1224|Proteobacteria,1TC0T@1236|Gammaproteobacteria,1YJMJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1007555_1 614083.AWQR01000014_gene2454 1.88e-140 401.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,4AAWU@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_3 moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_577063_1 580332.Slit_1783 1.03e-75 244.0 COG0517@1|root,COG4191@1|root,COG0517@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - CBS,HATPase_c,HisKA,Response_reg,dCache_1 k59_541679_1 760117.JN27_22050 7.23e-27 109.0 2980Z@1|root,2ZV71@2|Bacteria,1N8NK@1224|Proteobacteria,2VSYS@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_541679_2 159087.Daro_2413 1.18e-12 72.8 COG0726@1|root,COG1216@1|root,COG0726@2|Bacteria,COG1216@2|Bacteria,1MVKH@1224|Proteobacteria,2VIWN@28216|Betaproteobacteria,2KVT6@206389|Rhodocyclales 206389|Rhodocyclales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_611591_1 1000565.METUNv1_02500 2.12e-06 47.0 2CU7M@1|root,32SUS@2|Bacteria,1N1WF@1224|Proteobacteria,2VUS0@28216|Betaproteobacteria,2KWRI@206389|Rhodocyclales 206389|Rhodocyclales S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_611591_2 1123487.KB892841_gene4260 1.61e-47 161.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,2KVPB@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain tst - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_684277_1 497321.C664_09245 4.14e-53 168.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,2KW6N@206389|Rhodocyclales 206389|Rhodocyclales J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_684277_2 1000565.METUNv1_02289 3.85e-60 189.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,2KUIJ@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_511178_1 1121035.AUCH01000013_gene3147 9.82e-143 416.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,2KUJQ@206389|Rhodocyclales 206389|Rhodocyclales C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_7063_2 202954.BBNK01000008_gene1472 6.55e-44 147.0 COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,3NJ8F@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions rraA GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008428,GO:0009892,GO:0009894,GO:0009895,GO:0010605,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0032069,GO:0032074,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1902369 - ko:K02553 - - - - ko00000,ko03019 - - iJR904.b3929 RraA-like k59_113793_1 195250.CM001776_gene3422 7.89e-36 138.0 COG0745@1|root,COG0745@2|Bacteria,1G027@1117|Cyanobacteria,1H2TU@1129|Synechococcus 1117|Cyanobacteria T Hpt domain - - - - - - - - - - - - Hpt,Response_reg,Trans_reg_C k59_900761_2 1206731.BAGB01000041_gene8273 2.22e-05 48.5 COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_793257_1 522306.CAP2UW1_2205 1.04e-80 253.0 COG0745@1|root,COG0745@2|Bacteria,1QIP8@1224|Proteobacteria,2VNRG@28216|Betaproteobacteria 28216|Betaproteobacteria KT CRISPR-associated protein NE0113 (Cas_NE0113) - - - - - - - - - - - - Cas_NE0113 k59_720994_1 1464048.JNZS01000031_gene2936 6.67e-12 62.4 COG3152@1|root,COG3152@2|Bacteria,2IQHK@201174|Actinobacteria,4DFBW@85008|Micromonosporales 201174|Actinobacteria S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_720994_2 1000565.METUNv1_02180 4.59e-25 97.1 COG3666@1|root,COG3666@2|Bacteria,1Q0X4@1224|Proteobacteria,2W5U9@28216|Betaproteobacteria,2KZNE@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_333769_1 95619.PM1_0206105 2.83e-52 176.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily dppF - - ko:K12372,ko:K19230 ko01503,ko02010,map01503,map02010 M00324,M00739 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.5 - - ABC_tran,oligo_HPY k59_333769_2 1449050.JNLE01000005_gene4146 1.34e-08 55.8 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_863939_1 105559.Nwat_2289 7.16e-17 84.3 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1WWQT@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_721664_1 358220.C380_19825 1.51e-52 182.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9WN@80864|Comamonadaceae 28216|Betaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_721664_2 365046.Rta_34520 1.77e-85 256.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,4ADJC@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM N-acetylmuramoyl-L-alanine amidase family 2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_934775_1 1000565.METUNv1_03794 7.35e-237 662.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,2KUH9@206389|Rhodocyclales 206389|Rhodocyclales M D-Ala-D-Ala carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_934775_2 1000565.METUNv1_03795 1.83e-121 353.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,2VNGX@28216|Betaproteobacteria,2KUD0@206389|Rhodocyclales 206389|Rhodocyclales D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_1113055_1 644801.Psest_2771 1.14e-27 107.0 COG3619@1|root,COG3619@2|Bacteria,1NNMJ@1224|Proteobacteria,1SAT6@1236|Gammaproteobacteria,1YZTZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Protein of unknown function (DUF1275) - - - - - - - - - - - - DUF1275 k59_1113055_2 1000565.METUNv1_02213 4.29e-80 244.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2WGQC@28216|Betaproteobacteria,2KW6Z@206389|Rhodocyclales 206389|Rhodocyclales C Oxidoreductase NAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_685053_2 1209984.BN978_06531 1.32e-22 100.0 COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,23ETP@1762|Mycobacteriaceae 201174|Actinobacteria IQ Dehydrogenase reductase - - - - - - - - - - - iNJ661.Rv1928c adh_short_C2 k59_44373_1 1000565.METUNv1_03059 8.87e-27 100.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,2KWJJ@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_44373_2 1000565.METUNv1_03060 1.6e-200 562.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KUP7@206389|Rhodocyclales 206389|Rhodocyclales LU Rossmann fold nucleotide-binding protein involved in DNA uptake - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_512465_1 1000565.METUNv1_02622 9.87e-72 235.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KV2C@206389|Rhodocyclales 206389|Rhodocyclales NT COG0643 Chemotaxis protein histidine kinase and related kinases - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_830049_2 497321.C664_09793 8.42e-21 85.9 2EFX9@1|root,32YGP@2|Bacteria,1N7MN@1224|Proteobacteria,2VW9F@28216|Betaproteobacteria,2KXDY@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_191122_1 1392838.AWNM01000078_gene1122 5.43e-81 276.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_612223_2 1123487.KB892864_gene2204 2.24e-18 87.8 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KVME@206389|Rhodocyclales 206389|Rhodocyclales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_333802_1 862908.BMS_2933 1.83e-40 142.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2MUNY@213481|Bdellovibrionales,2WKG2@28221|Deltaproteobacteria 213481|Bdellovibrionales T PFAM sigma-54 factor interaction domain-containing protein flbD - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_333802_2 1201290.M902_1966 1.52e-08 56.2 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Beta-lactamase,DUF3471,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 k59_1113063_1 397945.Aave_4536 5.14e-51 166.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,4AB50@80864|Comamonadaceae 28216|Betaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1113063_2 296591.Bpro_4448 1.37e-61 191.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,4AEBS@80864|Comamonadaceae 28216|Betaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_333811_1 748247.AZKH_p0553 2.56e-21 94.4 COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,2VMQ1@28216|Betaproteobacteria,2KXPY@206389|Rhodocyclales 28216|Betaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR k59_333811_2 1123020.AUIE01000023_gene5001 0.000178 44.3 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_721678_2 1131462.DCF50_p1011 4.31e-14 76.6 COG2931@1|root,COG2931@2|Bacteria,1UY2D@1239|Firmicutes,249CK@186801|Clostridia,26086@186807|Peptococcaceae 186801|Clostridia Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - k59_794130_1 887062.HGR_06961 9.07e-78 253.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2VHPF@28216|Betaproteobacteria,4AB26@80864|Comamonadaceae 28216|Betaproteobacteria M Bacterial cellulose synthase subunit - - - ko:K20541 - - - - ko00000,ko02000 4.D.3.1.6 - - BcsB k59_191141_3 644076.SCH4B_3098 2.29e-17 81.6 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2TQWR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_655725_1 1120977.JHUX01000003_gene727 7.59e-89 275.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,3NJHT@468|Moraxellaceae 1236|Gammaproteobacteria C Soluble pyridine nucleotide transhydrogenase sthA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521 Pyr_redox_2,Pyr_redox_dim k59_612236_1 1000565.METUNv1_01293 8.49e-30 115.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,2KV3Y@206389|Rhodocyclales 206389|Rhodocyclales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_612236_2 1000565.METUNv1_01292 1.89e-105 327.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_79931_1 1163617.SCD_n02568 1.19e-22 102.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_901670_1 1123487.KB892866_gene1768 6.92e-36 128.0 COG3437@1|root,COG3437@2|Bacteria,1RDJ3@1224|Proteobacteria,2VR5G@28216|Betaproteobacteria,2KWE0@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_366026_1 1423144.Gal_01022 3.79e-08 58.5 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,34EEC@302485|Phaeobacter 28211|Alphaproteobacteria K helix_turn_helix, cAMP Regulatory protein MA20_39330 - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_863981_1 1461694.ATO9_18050 4.18e-28 105.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2PE1T@252301|Oceanicola 28211|Alphaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_863981_2 744872.Spica_0379 1.37e-16 79.3 COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes 203691|Spirochaetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_191160_1 1000565.METUNv1_00046 1.68e-127 406.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_366029_1 391735.Veis_1698 3.2e-34 127.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,4AAEK@80864|Comamonadaceae 28216|Betaproteobacteria E Required for the activity of the bacterial periplasmic transport system of putrescine potF - - ko:K11069,ko:K11073 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - SBP_bac_8 k59_366029_2 365046.Rta_01890 3.67e-49 165.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,4ACYJ@80864|Comamonadaceae 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_901676_1 748247.AZKH_p0163 1.03e-64 217.0 COG1018@1|root,COG3894@1|root,COG1018@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2VZBE@28216|Betaproteobacteria 28216|Betaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_970525_1 614083.AWQR01000005_gene1014 2.32e-233 657.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,4ABZP@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase phosphodiesterase yjcC - - - - - - - - - - - CBS,EAL,GGDEF k59_1008437_1 421072.IO89_17680 1.07e-41 156.0 COG3250@1|root,COG3250@2|Bacteria,4NGZH@976|Bacteroidetes,1HY22@117743|Flavobacteriia,3HIKG@358033|Chryseobacterium 976|Bacteroidetes M alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106,Glyco_hydro_2_N k59_44417_1 640081.Dsui_2856 4.3e-27 115.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria,2KVKM@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_295188_1 1000565.METUNv1_03883 6e-163 477.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KY8Z@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_1084149_1 1125863.JAFN01000001_gene2842 2.47e-07 58.9 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42TH2@68525|delta/epsilon subdivisions,2WQPG@28221|Deltaproteobacteria 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_612257_1 760117.JN27_10120 1.24e-44 145.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,474U3@75682|Oxalobacteraceae 28216|Betaproteobacteria G PTS HPr component phosphorylation site ptsH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_114689_1 321846.PS417_08230 8.59e-122 357.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RNG4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the DegT DnrJ EryC1 family ddhC - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_1113108_1 596154.Alide2_4686 5.07e-133 392.0 COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,4ABE1@80864|Comamonadaceae 28216|Betaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_295205_1 1288494.EBAPG3_6890 5.48e-102 300.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2VH7A@28216|Betaproteobacteria,371M9@32003|Nitrosomonadales 28216|Betaproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_258756_1 522306.CAP2UW1_3107 6.46e-59 198.0 COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2VHJN@28216|Betaproteobacteria 28216|Betaproteobacteria C L-Lactate permease glcA - - ko:K00427,ko:K03303 - - - - ko00000,ko02000 2.A.14,2.A.14.1.1 - - Lactate_perm k59_685124_2 1439940.BAY1663_00288 2.83e-48 170.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase k59_295208_1 1000565.METUNv1_00755 2.79e-199 558.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,2KUBR@206389|Rhodocyclales 206389|Rhodocyclales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_258762_1 1000565.METUNv1_02975 3.37e-73 240.0 COG1566@1|root,COG1566@2|Bacteria,1QVR9@1224|Proteobacteria,2W3A9@28216|Betaproteobacteria 28216|Betaproteobacteria V Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_4 k59_306769_2 62928.azo3788 1.44e-76 233.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2VI8M@28216|Betaproteobacteria,2KV5F@206389|Rhodocyclales 206389|Rhodocyclales C Prokaryotic cytochrome b561 - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_350080_1 358220.C380_13925 1.13e-89 293.0 COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,2VPE3@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_764807_1 1000565.METUNv1_02799 1.93e-58 187.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,2KVQS@206389|Rhodocyclales 206389|Rhodocyclales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_764807_2 1000565.METUNv1_02800 4.66e-94 275.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,2KWIG@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_269417_2 748727.CLJU_c01490 1.95e-22 99.4 COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae 186801|Clostridia M NLP P60 protein - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3 k59_943003_1 1502770.JQMG01000001_gene2375 2.38e-45 154.0 2DKYH@1|root,30WKQ@2|Bacteria,1RCXC@1224|Proteobacteria,2VR6P@28216|Betaproteobacteria,2KN4S@206350|Nitrosomonadales 206350|Nitrosomonadales S TIGRFAM EpsI family protein - - - - - - - - - - - - DUF3485 k59_943003_2 583345.Mmol_1025 4.09e-06 47.4 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria 28216|Betaproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_457599_1 1198452.Jab_2c00980 9.25e-70 225.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,47679@75682|Oxalobacteraceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - ko:K18903 - M00698 - - ko00000,ko00002,ko01504,ko02000 1.B.17.3.3 - - OEP k59_206800_1 1163617.SCD_n01413 5.62e-33 131.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_3,PAS_9,Response_reg k59_874843_1 1198452.Jab_2c17170 2.38e-08 53.9 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,4724G@75682|Oxalobacteraceae 28216|Betaproteobacteria J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_874843_2 1198452.Jab_2c17160 1.94e-112 331.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,472JS@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_483252_1 1000565.METUNv1_03514 6.01e-261 746.0 COG0642@1|root,COG3614@1|root,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,2WHGB@28216|Betaproteobacteria,2KY19@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_731381_2 1000565.METUNv1_00226 3.34e-157 450.0 COG4977@1|root,COG4977@2|Bacteria,1MXAU@1224|Proteobacteria,2VPXJ@28216|Betaproteobacteria,2KXCC@206389|Rhodocyclales 206389|Rhodocyclales K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_731381_3 1000565.METUNv1_00227 3.19e-30 110.0 2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,2VYVD@28216|Betaproteobacteria 28216|Betaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_672228_1 1276756.AUEX01000009_gene1836 1.59e-23 91.7 2EIWR@1|root,33CN2@2|Bacteria,1NI5Y@1224|Proteobacteria,2VYR5@28216|Betaproteobacteria,4AIBR@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1122342_1 62928.azo0514 4.44e-81 253.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2VKUY@28216|Betaproteobacteria,2KVVJ@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_980204_1 1198452.Jab_2c34190 1.73e-23 95.1 COG4566@1|root,COG4566@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K14987 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_529022_1 1000565.METUNv1_01356 4.44e-83 254.0 COG0491@1|root,COG0491@2|Bacteria,1RDXA@1224|Proteobacteria,2VSBH@28216|Betaproteobacteria,2KWZP@206389|Rhodocyclales 206389|Rhodocyclales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1056580_1 159087.Daro_1564 2.91e-65 206.0 COG1131@1|root,COG1131@2|Bacteria,1MXHE@1224|Proteobacteria,2VN8A@28216|Betaproteobacteria,2KVJR@206389|Rhodocyclales 206389|Rhodocyclales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1056580_2 1304883.KI912532_gene2096 2.62e-13 68.2 COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2VJGG@28216|Betaproteobacteria,2KUBY@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - ko:K02574 - - - - ko00000 - - - Fer4,Fer4_5 k59_1056589_2 497321.C664_04407 1.16e-53 172.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2VQ6H@28216|Betaproteobacteria,2KW2X@206389|Rhodocyclales 206389|Rhodocyclales KT PAS fold - - - - - - - - - - - - PAS_3 k59_839755_1 1454004.AW11_03386 1.25e-112 331.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1KQA5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P phosphate transporter pit - - ko:K03306,ko:K16322 - - - - ko00000,ko02000 2.A.20,2.A.20.1 - - PHO4 k59_206861_1 1122236.KB905143_gene44 2.45e-46 163.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2VHR0@28216|Betaproteobacteria,2KMAH@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM metal-dependent phosphohydrolase HD sub domain - - - - - - - - - - - - DUF3391,HD_5 k59_694845_1 1000565.METUNv1_03469 7.93e-90 269.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,2KUBV@206389|Rhodocyclales 206389|Rhodocyclales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_161089_1 1121870.AUAA01000010_gene1622 1.86e-08 53.9 COG4445@1|root,COG4445@2|Bacteria,4NFY4@976|Bacteroidetes,1HYKM@117743|Flavobacteriia,3HH23@358033|Chryseobacterium 976|Bacteroidetes FJ tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) miaE - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_161089_2 929556.Solca_3885 1.94e-57 189.0 COG2220@1|root,COG2220@2|Bacteria,4NENZ@976|Bacteroidetes,1IQQV@117747|Sphingobacteriia 976|Bacteroidetes S beta-lactamase romA - - - - - - - - - - - Lactamase_B_2 k59_269484_1 1121918.ARWE01000001_gene2821 1.27e-101 308.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria,43T0V@69541|Desulfuromonadales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_839764_1 1124780.ANNU01000035_gene273 3.1e-63 204.0 COG2008@1|root,COG2008@2|Bacteria,4NEIH@976|Bacteroidetes,47KXF@768503|Cytophagia 976|Bacteroidetes E Threonine aldolase ltaA - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_89212_1 640081.Dsui_1577 1.01e-146 427.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,2KV9Z@206389|Rhodocyclales 206389|Rhodocyclales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_483289_1 3988.XP_002534847.1 7.54e-51 172.0 KOG1199@1|root,KOG1199@2759|Eukaryota 2759|Eukaryota S 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity - - 1.1.1.178,1.1.1.35 ko:K08683 ko00280,ko01100,ko01110,ko01130,ko05010,map00280,map01100,map01110,map01130,map05010 - R04203 RC00525 ko00000,ko00001,ko01000,ko03029,ko04147 - - - adh_short k59_839766_1 1000565.METUNv1_00736 1.92e-81 253.0 COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,2VJ0W@28216|Betaproteobacteria,2KV1F@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1122373_1 983917.RGE_08230 4.7e-22 102.0 COG2831@1|root,COG2831@2|Bacteria,1MWWH@1224|Proteobacteria,2VU6Q@28216|Betaproteobacteria,1KME1@119065|unclassified Burkholderiales 28216|Betaproteobacteria U PFAM Ig domain protein, group 1 domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - - k59_228456_1 614083.AWQR01000030_gene2837 3.73e-16 77.4 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2VISJ@28216|Betaproteobacteria,4ABG7@80864|Comamonadaceae 28216|Betaproteobacteria CH PFAM monooxygenase FAD-binding - - 1.14.13.1 ko:K00480 ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220 - R00818,R05632,R06915,R06936,R06939 RC00389 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_228456_2 1320556.AVBP01000007_gene605 8.57e-16 79.0 COG3511@1|root,COG3511@2|Bacteria,1MVNS@1224|Proteobacteria,2U1QU@28211|Alphaproteobacteria,43QTK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Phosphoesterase family - - - - - - - - - - - - Phosphoesterase k59_54379_2 614083.AWQR01000055_gene1962 9.46e-81 248.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria,4ABEC@80864|Comamonadaceae 28216|Betaproteobacteria K response regulator lytT - - - - - - - - - - - LytTR,Response_reg k59_350245_1 1157708.KB907459_gene2060 8.2e-48 167.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9WN@80864|Comamonadaceae 28216|Betaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_350245_2 296591.Bpro_1111 7.33e-42 154.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,2WHEY@28216|Betaproteobacteria,4AJW2@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_1092916_2 1538295.JY96_17360 3.15e-21 90.1 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,2VUXR@28216|Betaproteobacteria,1KPBZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria P ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_839789_1 1268622.AVS7_02109 8.14e-08 51.6 COG1256@1|root,COG1256@2|Bacteria,1NMP9@1224|Proteobacteria,2VVX1@28216|Betaproteobacteria,4AFNB@80864|Comamonadaceae 28216|Betaproteobacteria N Flagellar basal body rod protein - - - - - - - - - - - - Flg_bb_rod,Flg_bbr_C k59_839789_2 296591.Bpro_5302 3.39e-38 141.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,4AAF0@80864|Comamonadaceae 28216|Betaproteobacteria C Pyrrolo-quinoline quinone exaA1 - 1.1.2.9,1.1.9.1 ko:K17760,ko:K20936 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ k59_350256_1 397945.Aave_2353 4e-56 191.0 COG4626@1|root,COG4626@2|Bacteria 2|Bacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_1122391_2 1288298.rosmuc_01688 2.13e-06 52.8 COG2021@1|root,COG2021@2|Bacteria,1RDEH@1224|Proteobacteria,2U267@28211|Alphaproteobacteria,46NGU@74030|Roseovarius 28211|Alphaproteobacteria E hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_89246_1 1217718.ALOU01000010_gene929 5.09e-56 188.0 COG3339@1|root,COG3619@1|root,COG3339@2|Bacteria,COG3619@2|Bacteria,1NNMJ@1224|Proteobacteria,2VIM6@28216|Betaproteobacteria,1K2V4@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1275) - - - - - - - - - - - - DUF1232,DUF1275 k59_529104_1 1123393.KB891330_gene828 2.08e-42 147.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,1KRBV@119069|Hydrogenophilales 119069|Hydrogenophilales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_529104_2 159087.Daro_0355 1.6e-57 180.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,2KWF2@206389|Rhodocyclales 206389|Rhodocyclales J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_731437_1 1000565.METUNv1_03505 1.39e-70 228.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria,2KVVX@206389|Rhodocyclales 206389|Rhodocyclales P COG0659 Sulfate permease and related transporters (MFS superfamily) sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_731437_2 1000565.METUNv1_03507 9.02e-88 262.0 COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,2VN1E@28216|Betaproteobacteria,2KUEP@206389|Rhodocyclales 206389|Rhodocyclales K transcriptional - - - - - - - - - - - - FCD,GntR k59_764896_1 246199.CUS_6364 2.32e-96 295.0 COG1479@1|root,COG1479@2|Bacteria,1UFE8@1239|Firmicutes,259DV@186801|Clostridia,3WQMZ@541000|Ruminococcaceae 186801|Clostridia S Protein of unknown function DUF262 - - - - - - - - - - - - DUF262 k59_764896_2 395494.Galf_0682 4.79e-106 342.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,44VA1@713636|Nitrosomonadales 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE k59_89267_1 358220.C380_07035 7.67e-39 137.0 28JGK@1|root,2Z9AA@2|Bacteria,1MWFY@1224|Proteobacteria,2VQFN@28216|Betaproteobacteria,4ADDS@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3034) - - - - - - - - - - - - DUF3034 k59_89267_2 864051.BurJ1DRAFT_3217 1.54e-18 83.2 COG2346@1|root,COG2346@2|Bacteria,1N005@1224|Proteobacteria,2VUH2@28216|Betaproteobacteria,1KMQ4@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_1122413_1 398578.Daci_1945 2.85e-100 301.0 2DTUK@1|root,33MQ2@2|Bacteria,1NPI3@1224|Proteobacteria,2W420@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_379339_1 1121033.AUCF01000013_gene1609 1.08e-112 336.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JPFJ@204441|Rhodospirillales 204441|Rhodospirillales S peptidase U62, modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1059578_1 1348657.M622_18480 7.18e-103 317.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VHBK@28216|Betaproteobacteria,2KVTF@206389|Rhodocyclales 206389|Rhodocyclales V COG0286 Type I restriction-modification system methyltransferase subunit - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_877006_1 1000565.METUNv1_02831 1.47e-195 548.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,2KVUF@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1094127_1 862908.BMS_2731 2.67e-54 188.0 COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Z2A@68525|delta/epsilon subdivisions,2MTND@213481|Bdellovibrionales,2WUNW@28221|Deltaproteobacteria 213481|Bdellovibrionales K Sigma-54 interaction domain - - - ko:K02584,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_532273_2 1159870.KB907784_gene1024 0.0 1387.0 COG3513@1|root,COG3513@2|Bacteria,1MVT9@1224|Proteobacteria,2VJ7J@28216|Betaproteobacteria,3T7JZ@506|Alcaligenaceae 28216|Betaproteobacteria L HNH endonuclease cas9 - - ko:K09952 - - - - ko00000,ko01000,ko02048 - - - HNH_4 k59_532273_3 535289.Dtpsy_0059 1.36e-154 440.0 COG1518@1|root,COG1518@2|Bacteria,1MX9W@1224|Proteobacteria,2VNWK@28216|Betaproteobacteria,4ACAR@80864|Comamonadaceae 28216|Betaproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_56332_1 207559.Dde_2879 2.16e-27 109.0 COG1215@1|root,COG1215@2|Bacteria,1REMC@1224|Proteobacteria,43AGJ@68525|delta/epsilon subdivisions,2WRT0@28221|Deltaproteobacteria,2MBRU@213115|Desulfovibrionales 28221|Deltaproteobacteria M glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_982036_1 43989.cce_3030 3.41e-35 145.0 COG1680@1|root,COG2931@1|root,COG1680@2|Bacteria,COG2931@2|Bacteria,1GE22@1117|Cyanobacteria,3KIGP@43988|Cyanothece 1117|Cyanobacteria V PFAM beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_230135_1 1123229.AUBC01000029_gene3519 1.88e-38 136.0 COG3861@1|root,COG3861@2|Bacteria,1NU42@1224|Proteobacteria,2TTV5@28211|Alphaproteobacteria,3JVXC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Photosynthetic reaction puhA - - ko:K13991 ko02020,map02020 - - - ko00000,ko00001,ko00194 - - - PRC,PRCH k59_230135_2 1443111.JASG01000002_gene88 2e-15 76.6 COG2211@1|root,COG2211@2|Bacteria,1QZ99@1224|Proteobacteria,2TZ09@28211|Alphaproteobacteria 28211|Alphaproteobacteria G BT1 family - - - ko:K08226 - - - - ko00000,ko02000 2.A.1.41 - - PUCC k59_842157_1 864073.HFRIS_013354 8.73e-90 291.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,472TT@75682|Oxalobacteraceae 28216|Betaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1059624_1 522306.CAP2UW1_3811 0.000355 40.4 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,1KR57@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_1059624_2 640081.Dsui_1746 4.96e-109 320.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2VIU6@28216|Betaproteobacteria,2KV4G@206389|Rhodocyclales 206389|Rhodocyclales N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_1020131_2 1095769.CAHF01000011_gene2022 2.82e-55 184.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_485677_1 247634.GPB2148_1196 1.53e-22 96.3 COG0583@1|root,COG0583@2|Bacteria,1R9J8@1224|Proteobacteria,1S0JZ@1236|Gammaproteobacteria,1J5I6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0583 Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_944771_1 614083.AWQR01000009_gene582 3.86e-121 359.0 COG0775@1|root,COG0775@2|Bacteria,1MUMQ@1224|Proteobacteria,2VKRE@28216|Betaproteobacteria,4AACG@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations amn - 3.2.2.4 ko:K01241 ko00230,map00230 - R00182 RC00063,RC00318 ko00000,ko00001,ko01000 - - - AMNp_N,PNP_UDP_1 k59_532346_1 700598.Niako_5270 2.14e-39 135.0 COG2050@1|root,COG2050@2|Bacteria,4NNXM@976|Bacteroidetes,1IY7V@117747|Sphingobacteriia 976|Bacteroidetes Q Domain of unknown function (DUF4442) - - - - - - - - - - - - DUF4442 k59_314449_1 102125.Xen7305DRAFT_00042900 1.52e-21 98.6 COG0612@1|root,COG0612@2|Bacteria,1G303@1117|Cyanobacteria,3VHKZ@52604|Pleurocapsales 1117|Cyanobacteria S PFAM Peptidase M16 inactive domain ymxG - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_846862_1 1156919.QWC_20892 3.63e-32 125.0 COG1475@1|root,COG1475@2|Bacteria,1NBHA@1224|Proteobacteria,2VWAS@28216|Betaproteobacteria,3T8GX@506|Alcaligenaceae 28216|Betaproteobacteria L DNA binding - - - - - - - - - - - - - k59_846862_2 765911.Thivi_1551 5.02e-34 118.0 COG3311@1|root,COG3311@2|Bacteria 2|Bacteria K DNA excision - - - ko:K07733 - - - - ko00000,ko03000 - - - Phage_AlpA k59_314465_1 1538295.JY96_17430 4.37e-108 328.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KK83@119065|unclassified Burkholderiales 28216|Betaproteobacteria JKL Belongs to the DEAD box helicase family rhlE1 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - - - - - - - - - - DEAD,Helicase_C k59_385541_1 497321.C664_13047 2.99e-31 122.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VU24@28216|Betaproteobacteria,2KZS9@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_948202_2 744872.Spica_1545 2.46e-13 68.9 COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2J5NQ@203691|Spirochaetes 203691|Spirochaetes C pyridine nucleotide-disulphide oxidoreductase dimerisation - - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k59_736837_1 1094558.ME5_01837 4.2e-99 295.0 COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Abhydrolase_1,Hydrolase_4 k59_490447_1 640081.Dsui_0933 3.3e-100 310.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,2KUF0@206389|Rhodocyclales 206389|Rhodocyclales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_915746_1 1417599.U6C6F9_9CAUD 1.22e-135 402.0 4QBD3@10239|Viruses,4QXFU@35237|dsDNA viruses no RNA stage,4QQ7Z@28883|Caudovirales,4QNJ0@10744|Podoviridae 10744|Podoviridae S P22 coat protein - gene protein 5 - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0008150,GO:0009987,GO:0016032,GO:0016043,GO:0019012,GO:0019028,GO:0019030,GO:0019058,GO:0019068,GO:0019069,GO:0019075,GO:0022607,GO:0039620,GO:0042802,GO:0042803,GO:0044085,GO:0044403,GO:0044419,GO:0044423,GO:0046729,GO:0046797,GO:0046983,GO:0051704,GO:0071840 - - - - - - - - - - - k59_915746_4 500635.MITSMUL_03138 2.6e-05 50.8 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - - k59_233480_1 1218074.BAXZ01000005_gene1389 8.79e-32 119.0 COG1309@1|root,COG1309@2|Bacteria,1N659@1224|Proteobacteria,2VS47@28216|Betaproteobacteria,1K29V@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator acrR - - ko:K03577 - M00647 - - ko00000,ko00002,ko03000 - - - TetR_C_2,TetR_N k59_736857_2 1095769.CAHF01000011_gene2695 1.13e-60 187.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,2VSCI@28216|Betaproteobacteria,474K8@75682|Oxalobacteraceae 28216|Betaproteobacteria S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_131062_1 281687.CJA14038b 5.64e-30 129.0 COG2801@1|root,2QT1S@2759|Eukaryota,39MJN@33154|Opisthokonta,3CP6B@33208|Metazoa,3E5AG@33213|Bilateria,40RED@6231|Nematoda,1M8IQ@119089|Chromadorea,40RYG@6236|Rhabditida 33208|Metazoa L transposition - - - - - - - - - - - - RVT_1,zf-CCHC k59_1065778_1 887327.HMPREF0476_1400 2.87e-59 192.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,2KPXV@206351|Neisseriales 206351|Neisseriales G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_1128166_1 1123248.KB893334_gene2759 2.26e-32 124.0 COG0732@1|root,COG0732@2|Bacteria,4NK11@976|Bacteroidetes,1IUNC@117747|Sphingobacteriia 976|Bacteroidetes V Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_1128166_2 85643.Tmz1t_3600 3.64e-11 64.3 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria,2KWA9@206389|Rhodocyclales 206389|Rhodocyclales L N-6 DNA Methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_560566_1 1000565.METUNv1_03805 1.6e-66 219.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_810594_1 1118054.CAGW01000017_gene4422 2.18e-40 144.0 COG0274@1|root,COG1051@1|root,COG0274@2|Bacteria,COG1051@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,26QH3@186822|Paenibacillaceae 91061|Bacilli F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - iSB619.SA_RS00835,iYO844.BSU39420 DeoC k59_986120_1 572544.Ilyop_1055 3.03e-31 124.0 COG0286@1|root,COG0286@2|Bacteria,3785A@32066|Fusobacteria 32066|Fusobacteria L HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_986120_2 1297569.MESS2_p80004 2.01e-49 164.0 2DU31@1|root,33NR4@2|Bacteria,1P40K@1224|Proteobacteria,2UWR5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4433) - - - - - - - - - - - - DUF4433 k59_810600_1 929703.KE386491_gene3404 6.72e-07 47.0 COG0333@1|root,COG0333@2|Bacteria,4NUXU@976|Bacteroidetes,47S89@768503|Cytophagia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_810600_2 926549.KI421517_gene1547 1.28e-34 125.0 COG1399@1|root,COG1399@2|Bacteria,4NMQT@976|Bacteroidetes,47QNM@768503|Cytophagia 976|Bacteroidetes S Uncharacterized ACR, COG1399 - - - - - - - - - - - - DUF177 k59_385627_1 1000565.METUNv1_01860 5.66e-171 483.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VH3S@28216|Betaproteobacteria,2KUAT@206389|Rhodocyclales 206389|Rhodocyclales E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_881236_1 1000565.METUNv1_03486 7.32e-10 57.0 COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2VMRF@28216|Betaproteobacteria,2KWN7@206389|Rhodocyclales 206389|Rhodocyclales O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly ureE - - ko:K03187 - - - - ko00000 - - - UreE_C,UreE_N k59_881236_2 1123255.JHYS01000002_gene2570 1.53e-194 550.0 COG1672@1|root,COG1672@2|Bacteria,1R8WG@1224|Proteobacteria,2VQHA@28216|Betaproteobacteria,4AJB5@80864|Comamonadaceae 28216|Betaproteobacteria S AAA ATPase domain - - - - - - - - - - - - - k59_1096745_1 639283.Snov_2149 9.95e-60 191.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,3EYN2@335928|Xanthobacteraceae 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1096745_2 1121033.AUCF01000001_gene2295 2.75e-06 49.3 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2JQPF@204441|Rhodospirillales 204441|Rhodospirillales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1128196_1 1000565.METUNv1_02456 2.16e-101 315.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - - - - - - - - - - GAF,T2SSE,T2SSE_N k59_810615_1 991.IW20_00670 4.82e-43 157.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1HZ0Y@117743|Flavobacteriia,2NTGW@237|Flavobacterium 976|Bacteroidetes EU Peptidase S9 pop GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - PD40,Peptidase_S9 k59_700817_1 1000565.METUNv1_02362 6.01e-69 227.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales 206389|Rhodocyclales T Type IV pili methyl-accepting chemotaxis transducer N-term - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3,PilJ k59_770010_1 755732.Fluta_0107 2.98e-43 159.0 COG5316@1|root,COG5316@2|Bacteria,4NGER@976|Bacteroidetes,1IJGS@117743|Flavobacteriia 976|Bacteroidetes P Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139,DUF4140,Plug k59_314578_1 666684.AfiDRAFT_1384 2e-71 224.0 28NJ8@1|root,2ZBKG@2|Bacteria,1R9DI@1224|Proteobacteria,2UAEF@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_490523_1 204773.HEAR0983 2.59e-38 135.0 COG1846@1|root,COG1846@2|Bacteria,1N7BV@1224|Proteobacteria,2VT79@28216|Betaproteobacteria,474XJ@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_593382_1 595537.Varpa_1061 1.09e-83 257.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VIST@28216|Betaproteobacteria,4AARE@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_772096_1 1121033.AUCF01000016_gene5513 7.57e-49 161.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,2JTCZ@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_278471_1 395494.Galf_0180 3.38e-147 429.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,44V7S@713636|Nitrosomonadales 28216|Betaproteobacteria J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1069921_1 748247.AZKH_p0170 4.25e-98 292.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,2KVJ6@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - Formyl_trans_N k59_317745_1 763034.HMPREF9446_01260 6.18e-25 102.0 COG1561@1|root,COG1561@2|Bacteria,4NEU4@976|Bacteroidetes,2FPBF@200643|Bacteroidia,4AKRI@815|Bacteroidaceae 976|Bacteroidetes S stress-induced protein - - - - - - - - - - - - DUF1732,YicC_N k59_317745_2 938709.AUSH02000045_gene329 1.23e-11 64.7 COG0697@1|root,COG0697@2|Bacteria,4NGZ3@976|Bacteroidetes 976|Bacteroidetes EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_812721_1 700598.Niako_5805 1.93e-70 238.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1IPY5@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_133790_2 1236517.BAKO01000005_gene978 1.29e-54 187.0 COG1216@1|root,COG1216@2|Bacteria,4NIW6@976|Bacteroidetes,2FSMP@200643|Bacteroidia 976|Bacteroidetes S Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glycos_transf_2 k59_1069946_1 1158050.KB895459_gene2582 1.47e-16 83.6 COG3511@1|root,COG3511@2|Bacteria,2IC2P@201174|Actinobacteria 201174|Actinobacteria M Phosphoesterase family - - - - - - - - - - - - Phosphoesterase k59_772117_1 1120936.KB907208_gene885 2.54e-64 203.0 COG1335@1|root,COG1335@2|Bacteria,2GKZR@201174|Actinobacteria,4ENEH@85012|Streptosporangiales 201174|Actinobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_563398_1 925409.KI911562_gene549 1.82e-53 185.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1IQWY@117747|Sphingobacteriia 976|Bacteroidetes E ACT domain thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_563398_2 1227739.Hsw_0012 8.38e-27 107.0 COG0083@1|root,COG0083@2|Bacteria,4NE2M@976|Bacteroidetes,47KGY@768503|Cytophagia 976|Bacteroidetes E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1069966_1 134676.ACPL_2255 7.46e-08 58.5 COG2207@1|root,COG2207@2|Bacteria,2IBP1@201174|Actinobacteria,4DGSW@85008|Micromonosporales 201174|Actinobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_1069970_1 1349767.GJA_2980 5.16e-46 154.0 COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2VSMR@28216|Betaproteobacteria,47258@75682|Oxalobacteraceae 28216|Betaproteobacteria K ANTAR nasT - - ko:K07183 - - - - ko00000,ko02022 - - - ANTAR,Response_reg k59_1130757_1 1198452.Jab_1c19480 6.77e-82 265.0 COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria,472RY@75682|Oxalobacteraceae 28216|Betaproteobacteria U Secretin and TonB N terminus short domain - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Cohesin,STN,Secretin,Secretin_N k59_169830_1 316274.Haur_4010 4.27e-40 147.0 COG1475@1|root,COG1475@2|Bacteria,2G735@200795|Chloroflexi,375G7@32061|Chloroflexia 32061|Chloroflexia K DNA binding - - - - - - - - - - - - DUF4032 k59_626369_1 378806.STAUR_7495 3.39e-30 115.0 COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,42QQ7@68525|delta/epsilon subdivisions,2WN8Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Linear amide C-N hydrolases, choloylglycine hydrolase family - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_849995_1 471854.Dfer_2139 7.97e-06 47.4 COG3395@1|root,COG3395@2|Bacteria,4NFF9@976|Bacteroidetes,47N65@768503|Cytophagia 976|Bacteroidetes S Putative nucleotide-binding of sugar-metabolising enzyme - - - - - - - - - - - - DUF1357_C,DUF1537 k59_849995_2 700598.Niako_3587 4.59e-64 201.0 COG4126@1|root,COG4126@2|Bacteria,4NHAM@976|Bacteroidetes,1IQAE@117747|Sphingobacteriia 976|Bacteroidetes E Asp Glu hydantoin racemase - - - - - - - - - - - - Asp_Glu_race k59_417573_1 1100721.ALKO01000008_gene2584 2.19e-84 256.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,4AC1G@80864|Comamonadaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_950473_1 365046.Rta_18690 1.24e-56 181.0 COG0638@1|root,COG0638@2|Bacteria,1QZDX@1224|Proteobacteria,2WHKN@28216|Betaproteobacteria,4AJZG@80864|Comamonadaceae 28216|Betaproteobacteria O Proteasome subunit - - - - - - - - - - - - Proteasome k59_950473_2 94624.Bpet3018 9.25e-08 52.4 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,3T2C5@506|Alcaligenaceae 28216|Betaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_626381_1 296591.Bpro_2408 6.22e-113 338.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,4AAW4@80864|Comamonadaceae 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_884889_1 688270.Celal_1775 8.76e-70 230.0 COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,4NENE@976|Bacteroidetes,1HXXF@117743|Flavobacteriia 976|Bacteroidetes P H( )-stimulated, divalent metal cation uptake system mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp,Usp k59_317842_1 667632.KB890164_gene2216 3.36e-48 169.0 28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,1K17Y@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_278565_1 279714.FuraDRAFT_2785 7.98e-113 333.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VHQB@28216|Betaproteobacteria 28216|Betaproteobacteria E ornithine cyclodeaminase - - 1.5.1.1 ko:K19743 ko00310,ko00330,ko00960,ko01100,map00310,map00330,map00960,map01100 - R01246,R01249,R02201,R02203 RC00135 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_563471_1 1000565.METUNv1_02719 6.32e-59 187.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,2KVHW@206389|Rhodocyclales 206389|Rhodocyclales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_563471_2 1000565.METUNv1_02718 3.02e-36 128.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,2KWJQ@206389|Rhodocyclales 206389|Rhodocyclales S HAD-hyrolase-like - - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_884948_1 1000565.METUNv1_02375 2.51e-52 178.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KU63@206389|Rhodocyclales 206389|Rhodocyclales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_1070128_2 1254432.SCE1572_43275 4.96e-08 56.2 COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria 1224|Proteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcpB - 1.11.1.15 ko:K03386,ko:K03564 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Redoxin k59_389729_2 1122951.ATUE01000006_gene1000 1.33e-59 194.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,1RRA4@1236|Gammaproteobacteria,3NIJ6@468|Moraxellaceae 1236|Gammaproteobacteria S Nitronate monooxygenase - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_278601_2 1100721.ALKO01000003_gene1953 8.65e-83 251.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VJXH@28216|Betaproteobacteria,4AAWP@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM nitrate ABC transporter, ATPase subunits C and D nasD - - ko:K02049,ko:K15578 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.17 - - ABC_tran k59_26497_1 1286631.X805_26280 1.41e-53 185.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1KJ35@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_884975_1 1385517.N800_03000 1.69e-89 276.0 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,1SKFF@1236|Gammaproteobacteria,1X3I6@135614|Xanthomonadales 135614|Xanthomonadales H glutamate--cysteine ligase gsh1 - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_317904_1 886293.Sinac_6199 1.2e-59 196.0 COG0500@1|root,COG0500@2|Bacteria,2IYP3@203682|Planctomycetes 203682|Planctomycetes Q O-methyltransferase - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_98792_1 1121033.AUCF01000011_gene1787 3.52e-38 133.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,2U7P9@28211|Alphaproteobacteria,2JT0Z@204441|Rhodospirillales 204441|Rhodospirillales NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_169933_1 1079460.ATTQ01000022_gene794 5.46e-104 317.0 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria,4B7KR@82115|Rhizobiaceae 28211|Alphaproteobacteria E ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_893346_1 1000565.METUNv1_02493 3.88e-64 197.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2VR2S@28216|Betaproteobacteria,2KWCD@206389|Rhodocyclales 206389|Rhodocyclales J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_893346_2 1000565.METUNv1_02495 3.77e-26 106.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,2KUSZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_214988_1 1000565.METUNv1_01185 8.71e-113 329.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VIX7@28216|Betaproteobacteria,2KU9Y@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_644990_1 1276756.AUEX01000040_gene343 2.91e-88 268.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2VK8J@28216|Betaproteobacteria,4ABGG@80864|Comamonadaceae 28216|Betaproteobacteria J Ribosomal RNA methyltransferase RrmJ FtsJ tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_1073318_2 706587.Desti_1823 7.13e-56 198.0 COG0745@1|root,COG3290@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_37580_1 365044.Pnap_2790 4.29e-126 383.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,4A9N2@80864|Comamonadaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_787270_1 765914.ThisiDRAFT_0591 5e-102 346.0 COG0642@1|root,COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X2PZ@135613|Chromatiales 135613|Chromatiales T catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - - - - - - - - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4,Response_reg k59_1108027_1 1000565.METUNv1_01008 7.46e-58 191.0 COG4447@1|root,COG4447@2|Bacteria,1RCCJ@1224|Proteobacteria,2VJGM@28216|Betaproteobacteria,2KVJ7@206389|Rhodocyclales 206389|Rhodocyclales S Photosynthesis system II assembly factor YCF48 - - - - - - - - - - - - PSII_BNR k59_858012_1 1000565.METUNv1_03846 2.94e-20 88.6 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales 206389|Rhodocyclales H enzyme of heme biosynthesis hemY - - ko:K02498 - - - - ko00000 - - - HemY_N k59_858012_3 1000565.METUNv1_03848 1.54e-45 158.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2VQ3C@28216|Betaproteobacteria,2KWSC@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_822601_1 1000565.METUNv1_00111 3.03e-86 280.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,2KUEK@206389|Rhodocyclales 206389|Rhodocyclales KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_1073342_1 159087.Daro_0815 1.51e-35 129.0 COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,2VH2D@28216|Betaproteobacteria,2KVGU@206389|Rhodocyclales 206389|Rhodocyclales E glycosyl transferase family - - - - - - - - - - - - Glycos_trans_3N,Glycos_transf_3 k59_251777_1 1458275.AZ34_17330 1.79e-110 319.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,4A9NY@80864|Comamonadaceae 28216|Betaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_394590_1 1000565.METUNv1_01076 1.67e-79 259.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_430763_1 1286093.C266_17591 1.49e-112 344.0 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,1K4KH@119060|Burkholderiaceae 28216|Betaproteobacteria P Arsenite-activated ATPase (ArsA) arsA - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase,CbiA k59_72807_1 365046.Rta_31650 2.43e-97 304.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_536866_1 485918.Cpin_6518 3.61e-30 108.0 COG0184@1|root,COG0184@2|Bacteria,4NS7U@976|Bacteroidetes,1ISVD@117747|Sphingobacteriia 976|Bacteroidetes J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_536866_2 1317122.ATO12_23265 2.32e-25 99.0 COG3631@1|root,COG3631@2|Bacteria,4NQGX@976|Bacteroidetes,1I3NE@117743|Flavobacteriia,2YJ5R@290174|Aquimarina 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_251794_1 1000565.METUNv1_01195 1.25e-61 214.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_287508_1 1286631.X805_05890 2.08e-154 441.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1KKA7@119065|unclassified Burkholderiales 28216|Betaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_465790_1 1000565.METUNv1_04045 6.41e-58 202.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_502306_1 1000565.METUNv1_02550 1.74e-151 441.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,2KVF9@206389|Rhodocyclales 206389|Rhodocyclales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_787305_1 1000565.METUNv1_02611 7.14e-121 372.0 COG0840@1|root,COG3829@1|root,COG0840@2|Bacteria,COG3829@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KU84@206389|Rhodocyclales 206389|Rhodocyclales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS,PAS_9,TarH k59_536869_1 83406.HDN1F_30170 7.57e-27 106.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_572477_1 1000565.METUNv1_02057 8.04e-114 343.0 COG1132@1|root,COG1132@2|Bacteria,1NU64@1224|Proteobacteria,2VZ6D@28216|Betaproteobacteria,2KY8F@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_572477_2 1123393.KB891316_gene1276 1.12e-150 429.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,1KRK5@119069|Hydrogenophilales 119069|Hydrogenophilales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - Formyl_trans_N k59_572477_3 1000565.METUNv1_02075 5.59e-82 249.0 COG3707@1|root,COG3707@2|Bacteria,1QZ0F@1224|Proteobacteria,2WHZP@28216|Betaproteobacteria 28216|Betaproteobacteria T ANTAR - - - ko:K22010 - M00839 - - ko00000,ko00002,ko02022 - - - ANTAR,Response_reg k59_108711_1 1000565.METUNv1_03241 2.9e-27 109.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,2KV0D@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain hoxJ - 2.7.13.3 ko:K19661 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4 k59_108711_2 1229781.C272_11663 4.1e-07 53.5 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - - - - - - - - - - EamA k59_858038_1 1123487.KB892866_gene1602 3e-54 196.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KUCK@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - CBS,CZB,EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_858038_2 159087.Daro_2792 3.76e-120 350.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,2KVET@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_965203_1 66692.ABC2862 1.76e-22 92.4 2B9XI@1|root,323AV@2|Bacteria,1V7VV@1239|Firmicutes,4HK2T@91061|Bacilli,1ZMSA@1386|Bacillus 91061|Bacilli S Protein of unknown function (DUF1071) - - - - - - - - - - - - DUF1071 k59_965203_2 1348657.M622_18510 2.13e-35 130.0 COG4227@1|root,COG4227@2|Bacteria,1MU8I@1224|Proteobacteria,2VMTV@28216|Betaproteobacteria,2KZ44@206389|Rhodocyclales 206389|Rhodocyclales L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738 k59_37627_1 305700.B447_00780 1.33e-200 567.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,2KVI3@206389|Rhodocyclales 206389|Rhodocyclales S SpoVR family - - - - - - - - - - - - SpoVR k59_394603_1 1000565.METUNv1_04065 3.3e-134 394.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,2KW7P@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,Response_reg k59_394603_2 1000565.METUNv1_04064 7.34e-114 331.0 COG2197@1|root,COG2197@2|Bacteria,1QW4D@1224|Proteobacteria,2VRAH@28216|Betaproteobacteria,2KWHM@206389|Rhodocyclales 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_394603_3 1000565.METUNv1_04063 1.37e-158 466.0 COG4206@1|root,COG4206@2|Bacteria,1QUWU@1224|Proteobacteria,2WGQG@28216|Betaproteobacteria,2KV16@206389|Rhodocyclales 206389|Rhodocyclales H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1001060_1 1294143.H681_20610 5.45e-21 92.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_430805_1 420662.Mpe_A1334 4.33e-37 140.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,1KPH5@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA1 - - ko:K07799 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_359000_1 1121035.AUCH01000021_gene2716 1.29e-64 201.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,2KWCE@206389|Rhodocyclales 206389|Rhodocyclales J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_359000_2 1304883.KI912532_gene2224 1.42e-14 72.4 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,2KVE3@206389|Rhodocyclales 206389|Rhodocyclales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_465806_1 755732.Fluta_1925 3.2e-20 87.8 COG0274@1|root,COG0274@2|Bacteria,4NGE3@976|Bacteroidetes,1ICQK@117743|Flavobacteriia,2PBS2@246874|Cryomorphaceae 976|Bacteroidetes F DeoC/LacD family aldolase deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_679652_1 1000565.METUNv1_00050 1.99e-62 201.0 COG1639@1|root,COG1639@2|Bacteria,1RASR@1224|Proteobacteria,2VR0D@28216|Betaproteobacteria,2KWNY@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_679652_2 1000565.METUNv1_00051 1.76e-237 662.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2VIT3@28216|Betaproteobacteria,2KUC5@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD_5,Response_reg k59_679652_4 1000565.METUNv1_00053 4.88e-106 310.0 COG1776@1|root,COG1776@2|Bacteria,1N4CX@1224|Proteobacteria,2WG21@28216|Betaproteobacteria 28216|Betaproteobacteria NT CheC-like family - - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC k59_1001067_1 1100721.ALKO01000003_gene1945 1.85e-65 220.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,4AJ2F@80864|Comamonadaceae 28216|Betaproteobacteria M Surface antigen - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_108722_1 1000565.METUNv1_01028 1e-82 254.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,2KUUI@206389|Rhodocyclales 206389|Rhodocyclales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine sua5 - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_715935_1 1216976.AX27061_3193 1.06e-37 145.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,3T1G5@506|Alcaligenaceae 28216|Betaproteobacteria NT Four helix bundle sensory module for signal transduction - - - ko:K03406,ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,TarH k59_608027_1 1157708.KB907450_gene5438 3.32e-40 153.0 28IJ1@1|root,2Z8K0@2|Bacteria,1R5PC@1224|Proteobacteria,2W0IK@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_679662_1 1000565.METUNv1_00177 2.15e-131 399.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,2KV9I@206389|Rhodocyclales 206389|Rhodocyclales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_965225_1 1000565.METUNv1_03424 7.5e-140 405.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2VN6Q@28216|Betaproteobacteria,2KV6K@206389|Rhodocyclales 206389|Rhodocyclales M Biotin-lipoyl like - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_965225_2 1000565.METUNv1_03425 1.42e-62 213.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY9@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_929240_1 596153.Alide_0470 1.19e-139 403.0 2DB8P@1|root,2Z7SB@2|Bacteria,1R765@1224|Proteobacteria,2VN78@28216|Betaproteobacteria,4AD0F@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_251838_1 1000565.METUNv1_01202 4.22e-210 615.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_215700_1 1000565.METUNv1_03594 9.69e-103 300.0 COG1396@1|root,COG1396@2|Bacteria,1MVQY@1224|Proteobacteria,2VI57@28216|Betaproteobacteria,2KYN4@206389|Rhodocyclales 206389|Rhodocyclales K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_645105_1 338969.Rfer_3433 4.59e-65 206.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,4A9RQ@80864|Comamonadaceae 28216|Betaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_645105_2 614083.AWQR01000021_gene224 1.37e-39 134.0 COG3116@1|root,COG3116@2|Bacteria,1N95M@1224|Proteobacteria,2VVTP@28216|Betaproteobacteria,4AEUR@80864|Comamonadaceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_929244_1 196367.JNFG01000204_gene432 2.38e-61 201.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2VH8K@28216|Betaproteobacteria,1K0KX@119060|Burkholderiaceae 28216|Betaproteobacteria E L-Serine dehydratase sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_929244_2 314287.GB2207_02217 4.58e-32 121.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,1RRHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Sarcosine oxidase, subunit beta soxB - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_679668_1 338969.Rfer_3416 1.51e-50 167.0 COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2VQPA@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1001085_1 279714.FuraDRAFT_2295 1.94e-70 217.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,2KQYA@206351|Neisseriales 206351|Neisseriales M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_965231_1 365044.Pnap_2705 3.61e-32 120.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VJPZ@28216|Betaproteobacteria,4A9Y3@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K13641 - - - - ko00000,ko03000 - - - HTH_IclR,IclR k59_965231_2 365044.Pnap_2704 4.49e-60 201.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2VJYH@28216|Betaproteobacteria,4ACA3@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein - - 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09884 RC00991 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_430848_1 1000565.METUNv1_00055 1.3e-121 359.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,2KUWY@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the mannose-6-phosphate isomerase type 2 family algA - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_751157_2 596154.Alide2_0428 9.39e-10 62.8 COG3598@1|root,COG3598@2|Bacteria,1PWN4@1224|Proteobacteria,2VP4D@28216|Betaproteobacteria,4AC3K@80864|Comamonadaceae 28216|Betaproteobacteria L AAA domain - - - ko:K06919 - - - - ko00000 - - - AAA_25 k59_108743_1 700598.Niako_2926 4.77e-84 271.0 COG1198@1|root,COG1198@2|Bacteria,4NFHB@976|Bacteroidetes,1IQGH@117747|Sphingobacteriia 976|Bacteroidetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_645109_1 936136.ARRT01000006_gene4136 6.77e-130 373.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,4BB11@82115|Rhizobiaceae 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_645109_2 1000565.METUNv1_02958 5.4e-307 842.0 2DBUQ@1|root,2ZB76@2|Bacteria,1R4DM@1224|Proteobacteria,2VP87@28216|Betaproteobacteria,2KVUH@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_645109_3 1000565.METUNv1_02957 5.35e-18 79.3 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,2VRCD@28216|Betaproteobacteria,2KWCR@206389|Rhodocyclales 206389|Rhodocyclales S Uncharacterised protein family (UPF0227) - - - ko:K07000 - - - - ko00000 - - - UPF0227 k59_72845_4 1127134.NOCYR_0367 4.69e-18 86.3 COG5519@1|root,COG5519@2|Bacteria,2HFY4@201174|Actinobacteria,4G40A@85025|Nocardiaceae 201174|Actinobacteria L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - Prim-Pol k59_251860_1 1000565.METUNv1_02513 9.43e-22 93.6 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,2KU8K@206389|Rhodocyclales 206389|Rhodocyclales P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_251860_2 94624.Bpet3561 3.59e-72 223.0 COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,2VJ5Z@28216|Betaproteobacteria,3T4A7@506|Alcaligenaceae 28216|Betaproteobacteria D Di-iron-containing protein involved in the repair of iron-sulfur clusters ytfE - - ko:K07322 - - - - ko00000 - - - Hemerythrin,ScdA_N k59_751163_1 1458427.BAWN01000003_gene144 7.09e-86 271.0 COG2066@1|root,COG2905@1|root,COG2066@2|Bacteria,COG2905@2|Bacteria,1MWB5@1224|Proteobacteria,2VIM8@28216|Betaproteobacteria,4ADKU@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the glutaminase family glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase k59_822680_1 1000565.METUNv1_02256 5.81e-209 616.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_858087_1 1000565.METUNv1_01876 1.82e-117 351.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,2KVUU@206389|Rhodocyclales 206389|Rhodocyclales C Malate synthase - - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_858087_2 1000565.METUNv1_01875 7e-133 382.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,2KV2D@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_394667_1 358220.C380_23125 1.22e-79 241.0 COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,2VQHV@28216|Betaproteobacteria,4ADQF@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_503828_1 1198452.Jab_1c08350 5.27e-09 55.8 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,472H4@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_503828_2 1198452.Jab_1c08300 3.4e-90 271.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,47677@75682|Oxalobacteraceae 28216|Betaproteobacteria S Displays ATPase and GTPase activities yhbJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_537827_1 1123073.KB899241_gene2896 6.14e-84 266.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1X3K4@135614|Xanthomonadales 135614|Xanthomonadales P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_145371_1 1218076.BAYB01000013_gene2789 9.13e-13 68.6 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,2VJ11@28216|Betaproteobacteria,1K0QM@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the NifD NifK NifE NifN family nifE - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_680599_1 1158292.JPOE01000002_gene2329 5.27e-123 362.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2VNHE@28216|Betaproteobacteria,1KMMF@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1074986_1 1121015.N789_06335 1.37e-21 96.3 COG0596@1|root,COG0596@2|Bacteria,1QVQ5@1224|Proteobacteria,1S5PD@1236|Gammaproteobacteria,1X5RP@135614|Xanthomonadales 135614|Xanthomonadales S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1 k59_864164_1 744872.Spica_1865 5.24e-95 291.0 COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes 203691|Spirochaetes P Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system mglA - 3.6.3.17 ko:K02056,ko:K10441,ko:K10542,ko:K10548 ko02010,map02010 M00212,M00214,M00216,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.5 - - ABC_tran k59_295379_1 1278307.KB907016_gene3415 4.73e-05 47.4 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2QIT6@267894|Psychromonadaceae 1236|Gammaproteobacteria T Domain of unknown function (DUF3369) - - - - - - - - - - - - DUF3369,HD,HD_5,Response_reg k59_334147_1 1000565.METUNv1_03166 6.68e-102 310.0 COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2WHI7@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_334147_2 1000565.METUNv1_03164 7.01e-54 177.0 COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2VJMU@28216|Betaproteobacteria,2KVWH@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_656079_1 1000565.METUNv1_03581 2.93e-53 182.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2W9QE@28216|Betaproteobacteria,2KZ9H@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_656079_2 1000565.METUNv1_03580 2.04e-12 66.2 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2W9R7@28216|Betaproteobacteria,2KZDB@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_258910_1 640081.Dsui_2841 7.25e-24 100.0 COG0641@1|root,COG0641@2|Bacteria,1NG2E@1224|Proteobacteria,2VMIE@28216|Betaproteobacteria,2KZTI@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_258910_2 640081.Dsui_2842 1.3e-37 128.0 2EH27@1|root,33AU6@2|Bacteria,1NN3U@1224|Proteobacteria,2W66U@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_656088_1 1122951.ATUE01000006_gene1305 3.03e-106 328.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,3NJC4@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_864190_1 1000565.METUNv1_01279 1.97e-90 267.0 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2VQPS@28216|Betaproteobacteria,2KYRI@206389|Rhodocyclales 206389|Rhodocyclales E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - - k59_864190_2 570967.JMLV01000002_gene1898 2.68e-91 277.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,2JRR1@204441|Rhodospirillales 204441|Rhodospirillales P COG0725 ABC-type molybdate transport system, periplasmic component modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_80088_1 1504672.669787054 6.42e-55 180.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,4AAC1@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_80088_2 159087.Daro_1180 3.03e-55 179.0 COG0745@1|root,COG0745@2|Bacteria,1R8UQ@1224|Proteobacteria,2VQE1@28216|Betaproteobacteria,2KW6W@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_864195_1 1122176.KB903536_gene1868 1.35e-07 57.4 COG3391@1|root,COG3391@2|Bacteria,4NSPG@976|Bacteroidetes 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - - k59_80091_1 477184.KYC_12643 2.2e-36 137.0 28N2X@1|root,2ZB8P@2|Bacteria,1R4KJ@1224|Proteobacteria,2WDTP@28216|Betaproteobacteria,3T8AJ@506|Alcaligenaceae 28216|Betaproteobacteria S sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7 - - - - - - - - - - - - - k59_80091_4 511.JT27_00555 1.09e-22 91.7 COG4570@1|root,COG4570@2|Bacteria,1NMFN@1224|Proteobacteria,2W5GT@28216|Betaproteobacteria,3T82Y@506|Alcaligenaceae 28216|Betaproteobacteria L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC - - - - - - - - - - - - - k59_970712_1 85643.Tmz1t_1063 1.05e-75 228.0 COG1487@1|root,COG1487@2|Bacteria,1Q93E@1224|Proteobacteria,2VV83@28216|Betaproteobacteria 28216|Betaproteobacteria S PIN domain - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_970712_2 1255043.TVNIR_2283 1.35e-10 57.8 COG4456@1|root,COG4456@2|Bacteria,1N85E@1224|Proteobacteria,1SH20@1236|Gammaproteobacteria,1X1TX@135613|Chromatiales 135613|Chromatiales S Antidote-toxin recognition MazE, bacterial antitoxin - - - ko:K18829 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_685294_2 864051.BurJ1DRAFT_0040 5.38e-36 129.0 COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VI89@28216|Betaproteobacteria,1KKRH@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Glutathione S-transferase gst - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_2,GST_N_3 k59_864204_1 338966.Ppro_2714 1.1e-39 152.0 COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,1PEPF@1224|Proteobacteria,439XC@68525|delta/epsilon subdivisions,2X1UM@28221|Deltaproteobacteria,43UUE@69541|Desulfuromonadales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HisKA_3,PAS_3 k59_1113278_1 1265502.KB905929_gene2254 6.92e-172 504.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2VHT2@28216|Betaproteobacteria,4A9NW@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_512886_1 1198452.Jab_1c24870 2.32e-38 142.0 COG3497@1|root,COG3497@2|Bacteria,1R3SE@1224|Proteobacteria,2VPMY@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage tail sheath protein subtilisin-like domain - - - ko:K06907 - - - - ko00000 - - - - k59_512886_2 1198452.Jab_1c24880 2.61e-46 154.0 2C2EC@1|root,32S1H@2|Bacteria,1MZBC@1224|Proteobacteria,2VVF0@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_219976_1 1000565.METUNv1_02445 7.3e-27 114.0 COG3170@1|root,COG3170@2|Bacteria,1RE27@1224|Proteobacteria,2VRNH@28216|Betaproteobacteria,2KW0V@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_1008657_1 614083.AWQR01000038_gene1400 5.61e-67 212.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,4AADT@80864|Comamonadaceae 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_441859_1 497321.C664_01545 4.94e-36 139.0 COG3852@1|root,COG4191@1|root,COG5002@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2W8ZR@28216|Betaproteobacteria,2KYIZ@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_935018_1 1000565.METUNv1_02929 1.13e-57 193.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,2KV1S@206389|Rhodocyclales 206389|Rhodocyclales D peptidase, M23 - - - - - - - - - - - - Peptidase_M23 k59_830316_1 62928.azo0408 3.88e-64 219.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KVQE@206389|Rhodocyclales 206389|Rhodocyclales T chemotaxis protein - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_334230_1 257313.BP0172 3.87e-42 150.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,3T2TP@506|Alcaligenaceae 28216|Betaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_334230_2 1000565.METUNv1_01237 2.15e-219 611.0 28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,2KVDQ@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2863) - - - - - - - - - - - - DUF2863 k59_543847_1 1121939.L861_16080 7.49e-36 133.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1XH2G@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_543847_2 391735.Veis_3225 5.15e-33 125.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2VH8K@28216|Betaproteobacteria,4AA7J@80864|Comamonadaceae 28216|Betaproteobacteria E serine dehydratase beta chain sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_1114380_1 399795.CtesDRAFT_PD3391 6e-101 310.0 COG0270@1|root,COG0270@2|Bacteria,1P5BJ@1224|Proteobacteria,2VK6K@28216|Betaproteobacteria,4AJD0@80864|Comamonadaceae 28216|Betaproteobacteria L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_260271_1 748280.NH8B_0778 1.51e-40 149.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VHFE@28216|Betaproteobacteria,2KPXM@206351|Neisseriales 206351|Neisseriales P Chloride transporter, ClC family - - - - - - - - - - - - Voltage_CLC k59_260278_1 1121920.AUAU01000004_gene729 1.17e-89 270.0 COG0037@1|root,COG0037@2|Bacteria,3Y548@57723|Acidobacteria 57723|Acidobacteria D PP-loop family - - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_515003_1 365044.Pnap_2855 4.06e-102 306.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,4AA00@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM isocitrate lyase and phosphorylmutase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_260285_1 338969.Rfer_2967 2.42e-88 262.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,4AAHE@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase sspA - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_578977_1 314260.PB2503_06397 1.46e-24 110.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria D protein involved in exopolysaccharide biosynthesis - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,GNVR,Wzz k59_757622_1 1123248.KB893381_gene1078 4.76e-39 145.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1IWKA@117747|Sphingobacteriia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - FG-GAP,UnbV_ASPIC,VCBS k59_336276_1 748247.AZKH_0194 2.09e-28 118.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVEE@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_578980_2 296591.Bpro_3368 3.94e-44 147.0 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VR37@28216|Betaproteobacteria,4AHU2@80864|Comamonadaceae 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_903149_1 509635.N824_21495 6.55e-36 135.0 COG2815@1|root,COG2815@2|Bacteria,4NSUI@976|Bacteroidetes,1ISPM@117747|Sphingobacteriia 976|Bacteroidetes S PFAM PASTA domain spk1 - 2.7.11.1,6.3.2.4 ko:K01921,ko:K08884,ko:K12132 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01001,ko01011 - - - PASTA k59_336287_1 1122951.ATUE01000013_gene1512 6.46e-48 156.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,1S6SA@1236|Gammaproteobacteria,3NNHR@468|Moraxellaceae 1236|Gammaproteobacteria C Succinate dehydrogenase hydrophobic membrane anchor subunit sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1086650_1 365044.Pnap_2311 2.51e-85 258.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,4AAY0@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM Serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_1086650_2 365044.Pnap_2312 2.33e-09 54.7 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,2VX71@28216|Betaproteobacteria 28216|Betaproteobacteria S May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_831599_1 375286.mma_2736 2.56e-11 62.8 COG0790@1|root,COG0790@2|Bacteria,1PV7Z@1224|Proteobacteria,2WB58@28216|Betaproteobacteria,476BJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - - - - - - - - - - - k59_116147_1 397945.Aave_3465 8.18e-70 221.0 COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,2VI94@28216|Betaproteobacteria,4ACEF@80864|Comamonadaceae 28216|Betaproteobacteria S Bile acid sodium symporter - - - ko:K14347 - - - - ko00000,ko02000,ko04147 2.A.93.1 - - SBF_like k59_193756_1 614083.AWQR01000010_gene1577 4.16e-35 132.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,4A9TZ@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_193756_2 1268622.AVS7_02667 1.29e-11 65.1 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria,4AGED@80864|Comamonadaceae 28216|Betaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,NIT k59_757650_1 631362.Thi970DRAFT_04326 8.82e-19 87.4 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales 135613|Chromatiales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_367826_1 1000565.METUNv1_01305 1.65e-92 276.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,2KV4J@206389|Rhodocyclales 206389|Rhodocyclales F Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage - - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_367826_2 420662.Mpe_A1813 1.82e-94 278.0 COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2VQ0U@28216|Betaproteobacteria,1KKMP@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def2 - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_367826_3 1000565.METUNv1_01303 5.58e-45 162.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_936205_1 279714.FuraDRAFT_0381 4.62e-21 89.4 COG0861@1|root,COG0861@2|Bacteria,1MXSK@1224|Proteobacteria,2VHZ5@28216|Betaproteobacteria,2KRRC@206351|Neisseriales 206351|Neisseriales P Integral membrane protein TerC family - - - - - - - - - - - - TerC k59_936205_2 640081.Dsui_1264 1.3e-31 117.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,2KWHE@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the phosphoglycerate mutase family gpmB - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_444196_1 1123257.AUFV01000009_gene2159 4.14e-170 488.0 COG3950@1|root,COG3950@2|Bacteria,1NT0V@1224|Proteobacteria,1RXY6@1236|Gammaproteobacteria,1X94Z@135614|Xanthomonadales 135614|Xanthomonadales S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 k59_152028_1 375286.mma_3380 6.9e-64 214.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,472XR@75682|Oxalobacteraceae 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_723127_2 1449347.JQLN01000004_gene6929 6.01e-29 110.0 COG1694@1|root,COG1694@2|Bacteria,2IQYH@201174|Actinobacteria,2M3VZ@2063|Kitasatospora 201174|Actinobacteria S Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - PRA-PH k59_613376_1 1000565.METUNv1_01859 1.6e-05 46.2 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_831635_1 614083.AWQR01000031_gene2629 1.52e-32 118.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2VJHT@28216|Betaproteobacteria,4ACJF@80864|Comamonadaceae 28216|Betaproteobacteria C PKHD-type hydroxylase ybiX - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_831635_2 614083.AWQR01000031_gene2628 5.01e-11 63.5 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,4AD9Q@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM TonB family protein tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_474055_2 399795.CtesDRAFT_PD2918 4.56e-06 45.4 2DSZH@1|root,33I26@2|Bacteria,1NJQ9@1224|Proteobacteria,2VXPA@28216|Betaproteobacteria,4AG5B@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3149) - - - - - - - - - - - - DUF3149 k59_515145_1 1121035.AUCH01000005_gene14 1.48e-20 89.4 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_193850_1 1000565.METUNv1_03805 1.75e-95 296.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_444240_1 543728.Vapar_2750 7.35e-75 234.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,4AB6N@80864|Comamonadaceae 28216|Betaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1010002_1 305700.B447_04162 9.45e-56 181.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHJD@28216|Betaproteobacteria,2KYBW@206389|Rhodocyclales 206389|Rhodocyclales O Glutathione S-transferase - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C_2,GST_N k59_686506_1 1000565.METUNv1_02802 1.68e-109 323.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2WI38@28216|Betaproteobacteria 28216|Betaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - - - - - - - - - - - Iso_dh k59_9530_1 1000565.METUNv1_03847 1.23e-160 461.0 COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,2VMS5@28216|Betaproteobacteria,2KW4H@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF898) - - - - - - - - - - - - DUF898 k59_831670_1 317025.Tcr_1150 5.45e-65 224.0 COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,45ZZR@72273|Thiotrichales 72273|Thiotrichales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9 k59_313419_1 1177179.A11A3_00930 1.15e-59 193.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1XJ9U@135619|Oceanospirillales 135619|Oceanospirillales S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_313419_2 1298593.TOL_0031 2.32e-17 78.6 COG3151@1|root,COG3151@2|Bacteria,1RA4E@1224|Proteobacteria,1SA3I@1236|Gammaproteobacteria,1XJWR@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09920 - - - - ko00000 - - - DUF1249 k59_414440_1 7209.EFO28128.2 1.85e-06 57.4 COG1132@1|root,KOG0054@2759|Eukaryota,38CH6@33154|Opisthokonta,3BAG8@33208|Metazoa,3CSJ8@33213|Bilateria,40CED@6231|Nematoda,1KTPA@119089|Chromadorea 33208|Metazoa Q ABC transporter transmembrane region mrp-5 - - ko:K05668,ko:K05673,ko:K21863 ko01523,ko02010,ko04024,ko04976,map01523,map02010,map04024,map04976 - - - ko00000,ko00001,ko02000,ko04040 1.A.1.11.15,3.A.1.208.15,3.A.1.208.7 - - ABC_membrane,ABC_tran k59_1023715_2 1500894.JQNN01000001_gene2598 6.7e-23 97.1 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,2VHVZ@28216|Betaproteobacteria,4728P@75682|Oxalobacteraceae 28216|Betaproteobacteria N SRP54-type protein, GTPase domain flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_1064650_1 1000565.METUNv1_01392 1.23e-23 96.3 COG0265@1|root,COG0265@2|Bacteria,1RDHW@1224|Proteobacteria,2VRY7@28216|Betaproteobacteria,2KZ9R@206389|Rhodocyclales 28216|Betaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - TPR_2,TPR_8,Trypsin_2 k59_313453_1 1267535.KB906767_gene890 6.01e-20 91.3 COG0531@1|root,COG0531@2|Bacteria,3Y7AX@57723|Acidobacteria 57723|Acidobacteria E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_313453_2 378806.STAUR_7495 3.27e-41 145.0 COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,42QQ7@68525|delta/epsilon subdivisions,2WN8Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Linear amide C-N hydrolases, choloylglycine hydrolase family - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_166211_1 1248760.ANFZ01000018_gene750 1.39e-21 95.9 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K0Z1@204457|Sphingomonadales 204457|Sphingomonadales NT chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_166211_2 1515746.HR45_07075 3.52e-08 57.4 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2Q95S@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_947508_1 159087.Daro_0174 6.72e-91 296.0 COG0110@1|root,COG0663@1|root,COG1020@1|root,COG0110@2|Bacteria,COG0663@2|Bacteria,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,2KW0H@206389|Rhodocyclales 206389|Rhodocyclales Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Hexapep,PP-binding k59_130169_1 292.DM42_1773 2.03e-148 444.0 COG0470@1|root,COG0470@2|Bacteria,1MVEE@1224|Proteobacteria,2VP7K@28216|Betaproteobacteria,1KBKF@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase III - - - - - - - - - - - - - k59_880323_1 1114970.PSF113_2303 3.01e-40 139.0 COG3708@1|root,COG3708@2|Bacteria,1N1C4@1224|Proteobacteria,1S7YJ@1236|Gammaproteobacteria,1YQ76@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K Bacterial transcription activator, effector binding domain - - - - - - - - - - - - Cass2 k59_623734_2 555793.WSK_0357 7.52e-18 77.8 COG3860@1|root,COG3860@2|Bacteria,1N8HB@1224|Proteobacteria,2UGZ1@28211|Alphaproteobacteria,2K70F@204457|Sphingomonadales 204457|Sphingomonadales S Transcriptional regulator - - - - - - - - - - - - - k59_985230_1 1296415.JACC01000003_gene3084 1.61e-74 248.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,2YGHV@290174|Aquimarina 976|Bacteroidetes G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_414478_1 1000565.METUNv1_02955 2.6e-47 164.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,2KUYN@206389|Rhodocyclales 206389|Rhodocyclales M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_130175_2 395494.Galf_1027 2.19e-17 77.4 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,2VWS3@28216|Betaproteobacteria,44WKJ@713636|Nitrosomonadales 28216|Betaproteobacteria T STAS domain - - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS_2 k59_590435_1 1223521.BBJX01000011_gene9 2.43e-65 209.0 COG1373@1|root,COG1373@2|Bacteria,1R4HK@1224|Proteobacteria,2VMYI@28216|Betaproteobacteria 28216|Betaproteobacteria S ATPase (AAA superfamily - - - - - - - - - - - - - k59_985236_1 76114.ebA3059 9.64e-20 85.9 2BW01@1|root,32RUH@2|Bacteria,1N665@1224|Proteobacteria,2VVCA@28216|Betaproteobacteria,2KWYH@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_489497_1 398527.Bphyt_1300 7.25e-116 343.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,1K12P@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_59438_1 1122951.ATUE01000008_gene159 3.49e-104 312.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,3NKCG@468|Moraxellaceae 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1127270_1 1000565.METUNv1_02087 5.84e-60 189.0 COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - - - - - - - - - - DUF2244 k59_1127270_2 1000565.METUNv1_02086 1.37e-103 313.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,2KUZ4@206389|Rhodocyclales 206389|Rhodocyclales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_985244_2 1101195.Meth11DRAFT_1454 8.11e-17 81.6 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2VQQ0@28216|Betaproteobacteria,2KNX3@206350|Nitrosomonadales 206350|Nitrosomonadales C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_769270_1 1112274.KI911560_gene503 2.4e-16 77.0 COG3038@1|root,COG3038@2|Bacteria,1Q1ZX@1224|Proteobacteria,2WA52@28216|Betaproteobacteria,2KNXX@206350|Nitrosomonadales 206350|Nitrosomonadales C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_915031_1 1000565.METUNv1_03462 8.55e-124 367.0 COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,2KXG7@206389|Rhodocyclales 206389|Rhodocyclales S Alkaline phosphatase - - - - - - - - - - - - - k59_313514_1 1000565.METUNv1_01292 1.07e-100 313.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_736152_1 1000565.METUNv1_02625 1.74e-142 425.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KUCK@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1023785_1 748247.AZKH_4078 5.24e-119 345.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2VIK4@28216|Betaproteobacteria,2KUME@206389|Rhodocyclales 206389|Rhodocyclales P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_590466_1 472759.Nhal_0612 1.79e-16 83.2 COG0438@1|root,COG0438@2|Bacteria,1R01U@1224|Proteobacteria,1RREV@1236|Gammaproteobacteria,1WWC3@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 k59_1064750_1 1123393.KB891332_gene2834 5.07e-91 287.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KRIV@119069|Hydrogenophilales 119069|Hydrogenophilales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C2 k59_274960_1 365044.Pnap_1162 6.2e-111 339.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VQA9@28216|Betaproteobacteria,4AHFV@80864|Comamonadaceae 28216|Betaproteobacteria EQ PFAM Hydantoinase B oxoprolinase - - 6.4.1.8 ko:K10701 ko00642,ko01120,ko01220,map00642,map01120,map01220 - R05453 RC00040 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_845995_1 420662.Mpe_A0093 2.72e-58 192.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,1KK3K@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_590480_1 1000565.METUNv1_02335 3.3e-137 404.0 COG0714@1|root,COG0714@2|Bacteria,1PM35@1224|Proteobacteria,2VM64@28216|Betaproteobacteria,2KW19@206389|Rhodocyclales 206389|Rhodocyclales O AAA domain (dynein-related subfamily) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5 k59_736174_1 640081.Dsui_0607 4.13e-19 80.9 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,2KWBC@206389|Rhodocyclales 206389|Rhodocyclales S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_736174_2 522306.CAP2UW1_3603 1.53e-81 253.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,1KPWU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L Belongs to the methyltransferase superfamily rlmL - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_559614_1 1000565.METUNv1_00201 6.21e-69 225.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJR2@28216|Betaproteobacteria,2KWPD@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - CHASE3,HATPase_c,HisKA_3 k59_232870_1 640081.Dsui_2935 4.43e-96 290.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,2KVAK@206389|Rhodocyclales 206389|Rhodocyclales C NAD(P) transhydrogenase, alpha subunit pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1096236_1 266264.Rmet_2163 3.4e-57 199.0 COG0699@1|root,COG1396@1|root,COG0699@2|Bacteria,COG1396@2|Bacteria,1R3H5@1224|Proteobacteria,2W19D@28216|Betaproteobacteria 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_313579_1 136993.KB900626_gene2227 1.13e-83 262.0 COG0491@1|root,COG0491@2|Bacteria,1R6GR@1224|Proteobacteria,2U3IN@28211|Alphaproteobacteria,36ZA7@31993|Methylocystaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_985310_1 296591.Bpro_2988 1.24e-47 159.0 COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKUM@28216|Betaproteobacteria,4ABGV@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_985310_2 312284.A20C1_07928 4.84e-05 45.8 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,3UWHM@52018|unclassified Actinobacteria (class) 201174|Actinobacteria P COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_846028_1 1071679.BG57_20865 5.45e-113 333.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,1K2VU@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_559629_2 1121033.AUCF01000005_gene5328 6.81e-14 72.4 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TZDS@28211|Alphaproteobacteria,2JZ03@204441|Rhodospirillales 204441|Rhodospirillales T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_166308_1 614083.AWQR01000021_gene218 2.4e-85 264.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,4ABEI@80864|Comamonadaceae 28216|Betaproteobacteria D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_130271_1 686340.Metal_2289 2.53e-75 246.0 COG1816@1|root,COG1816@2|Bacteria 2|Bacteria F deaminase activity CP_0600 - 3.5.4.2,3.5.4.4 ko:K01488,ko:K21053 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01244,R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase,Cas_NE0113 k59_623809_1 883126.HMPREF9710_03870 5.33e-10 60.1 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,473P4@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter C-terminal domain uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_985322_1 1297570.MESS4_120222 6.49e-07 50.4 COG1055@1|root,COG1055@2|Bacteria,1MXKG@1224|Proteobacteria,2TRB1@28211|Alphaproteobacteria,43J4Q@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Putative citrate transport - - - - - - - - - - - - CitMHS_2 k59_985322_2 296591.Bpro_2046 6.97e-160 461.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,4AARZ@80864|Comamonadaceae 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_384611_1 1121033.AUCF01000008_gene5584 8.94e-56 187.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,2JPBT@204441|Rhodospirillales 204441|Rhodospirillales S Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_384611_2 936455.KI421499_gene689 6.58e-18 83.6 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JWSI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Phosphoglucose isomerase pgi GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_559646_1 1000565.METUNv1_02812 4.91e-115 343.0 COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria,2KYFR@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c k59_985325_1 1504672.669782951 6.35e-108 333.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,4A9VA@80864|Comamonadaceae 28216|Betaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_166319_1 1123277.KB893217_gene4435 1.82e-64 219.0 COG4206@1|root,COG4206@2|Bacteria,4NK95@976|Bacteroidetes,47MFX@768503|Cytophagia 976|Bacteroidetes H Outer membrane protein beta-barrel family - - - - - - - - - - - - OMP_b-brl_3,Plug k59_59518_1 1349767.GJA_1143 1.63e-79 245.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,472NX@75682|Oxalobacteraceae 28216|Betaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_590519_1 643473.KB235930_gene1881 3.93e-11 71.6 COG1361@1|root,COG2931@1|root,COG3210@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1GJ9G@1117|Cyanobacteria,1HR22@1161|Nostocales 1117|Cyanobacteria QU PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme - - 3.4.21.10 ko:K01317 - - - - ko00000,ko01000,ko01002,ko04131 - - - DUF4347,Lactonase k59_915124_1 1276756.AUEX01000005_gene2845 4.27e-35 123.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,2VRC4@28216|Betaproteobacteria,4AE4Z@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_915124_2 365044.Pnap_2355 2.23e-13 64.7 COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria 1224|Proteobacteria S Transmembrane anti-sigma factor - - - - - - - - - - - - zf-HC2 k59_769352_1 1120977.JHUX01000004_gene2188 2.27e-55 182.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1RYHF@1236|Gammaproteobacteria,3NKC7@468|Moraxellaceae 1236|Gammaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_769352_2 1122194.AUHU01000002_gene2490 9.53e-27 107.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,465ZV@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_700019_1 1244869.H261_13409 1.49e-28 117.0 COG4191@1|root,COG4191@2|Bacteria,1REIK@1224|Proteobacteria,2US9W@28211|Alphaproteobacteria,2JWWW@204441|Rhodospirillales 204441|Rhodospirillales T C4-dicarboxylate transport sensor protein dctB - - - - - - - - - - - - GAF_2,PAS k59_132656_1 1499967.BAYZ01000028_gene1345 7.98e-09 58.5 COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB k59_387939_1 375286.mma_0047 2.57e-17 79.0 COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,2VRT2@28216|Betaproteobacteria,47483@75682|Oxalobacteraceae 28216|Betaproteobacteria H Nicotinamide mononucleotide transporter pnuC - - ko:K03811 - - - - ko00000,ko02000 4.B.1.1 - - NMN_transporter k59_387939_2 29581.BW37_01521 4.33e-46 163.0 COG3591@1|root,COG3591@2|Bacteria,1MYRM@1224|Proteobacteria,2WFYI@28216|Betaproteobacteria,4790B@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 k59_492196_1 391735.Veis_0459 2.69e-108 339.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria,2W9Z8@28216|Betaproteobacteria,4AHQE@80864|Comamonadaceae 28216|Betaproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_387942_1 172045.KS04_13745 1.16e-20 95.1 COG1566@1|root,COG1566@2|Bacteria,4NEQJ@976|Bacteroidetes,1I163@117743|Flavobacteriia,34PSP@308865|Elizabethkingia 976|Bacteroidetes V HlyD membrane-fusion protein of T1SS - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_702290_1 558884.JRGM01000008_gene3441 7.3e-46 163.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,1RP5M@1236|Gammaproteobacteria,1Y3DN@135624|Aeromonadales 135624|Aeromonadales V Multidrug resistance protein MdtK - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_416556_1 1121920.AUAU01000009_gene1880 6.97e-83 253.0 COG0564@1|root,COG0564@2|Bacteria 2|Bacteria J pseudouridine synthase activity - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_883010_1 936053.I1BM10 4.16e-51 188.0 COG2801@1|root,KOG0017@2759|Eukaryota,3AFVE@33154|Opisthokonta,3PCPI@4751|Fungi,1GXN4@112252|Fungi incertae sedis 4751|Fungi B Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,rve k59_388012_1 640081.Dsui_0243 3.6e-84 265.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,2KUNQ@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_848717_1 614083.AWQR01000025_gene3740 2.61e-109 336.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,4AAXI@80864|Comamonadaceae 28216|Betaproteobacteria C Phosphate acetyl butaryl transferase maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_738218_1 375286.mma_0278 4.79e-146 422.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,473A8@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.2,1.4.1.3 ko:K00260,ko:K00261 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_738218_2 1198452.Jab_1c23960 1.28e-87 267.0 COG0583@1|root,COG0583@2|Bacteria,1R4QT@1224|Proteobacteria,2VI4T@28216|Betaproteobacteria,47314@75682|Oxalobacteraceae 28216|Betaproteobacteria K PFAM Bacterial regulatory helix-turn-helix protein, lysR family, LysR substrate binding domain - - - ko:K21645 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1068207_1 946483.Cenrod_1477 5.31e-46 168.0 COG0642@1|root,COG0784@1|root,COG3850@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG3850@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_702346_1 930166.CD58_15765 4.22e-07 52.8 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_9 k59_702346_2 1005048.CFU_3292 9.02e-36 125.0 COG4539@1|root,COG4539@2|Bacteria,1N1G8@1224|Proteobacteria,2VRIU@28216|Betaproteobacteria,474DD@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF962) - - - - - - - - - - - - DUF962 k59_562434_2 864073.HFRIS_020326 3.66e-20 89.4 COG1680@1|root,COG1680@2|Bacteria,1R49D@1224|Proteobacteria,2WCNR@28216|Betaproteobacteria,477YU@75682|Oxalobacteraceae 28216|Betaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_97566_1 1122951.ATUE01000010_gene297 3.72e-40 142.0 COG1024@1|root,COG1024@2|Bacteria,1RIVB@1224|Proteobacteria,1S80Y@1236|Gammaproteobacteria,3NMHS@468|Moraxellaceae 1236|Gammaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_25404_1 1000565.METUNv1_02507 1.92e-135 414.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KV93@206389|Rhodocyclales 206389|Rhodocyclales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_811945_1 1316927.ATKI01000078_gene898 7.28e-65 223.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YQ2C@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Condensation domain - - - ko:K15659 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_168758_1 365046.Rta_22830 5.66e-73 240.0 COG1538@1|root,COG1538@2|Bacteria,1MUHM@1224|Proteobacteria,2VKX1@28216|Betaproteobacteria,4AGG7@80864|Comamonadaceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_562460_1 1198452.Jab_2c02880 2.52e-127 378.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,473HI@75682|Oxalobacteraceae 28216|Betaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_811961_1 1219031.BBJR01000034_gene2266 1.85e-16 80.9 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria 28216|Betaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_2972_2 1000565.METUNv1_02426 2.27e-188 531.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,2KUKJ@206389|Rhodocyclales 206389|Rhodocyclales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_73802_1 1000565.METUNv1_03215 1.72e-50 161.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,2VUFZ@28216|Betaproteobacteria,2KX2G@206389|Rhodocyclales 206389|Rhodocyclales S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_73802_2 1000565.METUNv1_03214 1.09e-28 111.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VJKH@28216|Betaproteobacteria,2KUUA@206389|Rhodocyclales 206389|Rhodocyclales KO Hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_538704_2 497964.CfE428DRAFT_1388 2.92e-31 117.0 COG1595@1|root,COG1595@2|Bacteria,46STJ@74201|Verrucomicrobia 74201|Verrucomicrobia K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_824721_1 485918.Cpin_1224 1.17e-38 134.0 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,1IPM8@117747|Sphingobacteriia 976|Bacteroidetes T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_824721_2 1122605.KB893626_gene2575 1.95e-35 131.0 COG5002@1|root,COG5002@2|Bacteria,4NETP@976|Bacteroidetes,1IQ3E@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_574209_1 1538295.JY96_01940 1.72e-17 83.6 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,2VH5K@28216|Betaproteobacteria,1KKHY@119065|unclassified Burkholderiales 28216|Betaproteobacteria KLT Serine/threonine phosphatases, family 2C, catalytic domain prkC2 - 2.7.11.1,3.1.3.16 ko:K01090,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PP2C_2,Pkinase,TPR_16,TPR_19,TPR_8 k59_183928_1 1000565.METUNv1_03163 9.06e-12 63.9 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,2KVA8@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_183928_2 1000565.METUNv1_03162 3.42e-240 676.0 COG5001@1|root,COG5001@2|Bacteria,1QYKY@1224|Proteobacteria,2WEWC@28216|Betaproteobacteria,2KYIW@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_896686_1 1249480.B649_07830 2.63e-92 275.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,42Z24@68525|delta/epsilon subdivisions,2YRNA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PKHD-type hydroxylase - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_146142_1 1042209.HK44_009125 1.85e-14 77.0 COG2984@1|root,COG2984@2|Bacteria,1NACH@1224|Proteobacteria,1SEI1@1236|Gammaproteobacteria,1YN9Q@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind k59_146142_2 1397527.Q670_07095 1.78e-07 54.3 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XI95@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_397173_1 1122603.ATVI01000001_gene1883 1.12e-51 176.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1X4P9@135614|Xanthomonadales 135614|Xanthomonadales S Methyltransferase - - - - - - - - - - - - Methyltransf_33 k59_574210_1 1288963.ADIS_4752 1.49e-68 219.0 COG0499@1|root,COG0499@2|Bacteria,4NEKE@976|Bacteroidetes,47KGI@768503|Cytophagia 976|Bacteroidetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_254166_1 880072.Desac_0141 3.82e-44 166.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg k59_290045_1 543728.Vapar_3510 2.69e-73 220.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,4AE1G@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_290045_2 1504672.669786539 3.08e-96 280.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,4ACEJ@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_40088_1 159087.Daro_1113 2.97e-94 277.0 COG3470@1|root,COG3470@2|Bacteria,1RA2Z@1224|Proteobacteria,2VQ7Y@28216|Betaproteobacteria,2KUXI@206389|Rhodocyclales 206389|Rhodocyclales P Fe2+ transport protein - - - ko:K07230 - - - - ko00000,ko02000 2.A.108.2.10,2.A.108.2.4,2.A.108.2.9 - - Iron_transport k59_40088_2 1123392.AQWL01000005_gene3037 8.09e-09 59.7 COG3659@1|root,COG3659@2|Bacteria,1Q8C7@1224|Proteobacteria,2VJFC@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM Carbohydrate-selective porin OprB - - - - - - - - - - - - OprB k59_1003098_1 1502770.JQMG01000001_gene993 6.74e-27 98.6 2DDM5@1|root,2ZII8@2|Bacteria,1P40F@1224|Proteobacteria,2W552@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_326821_1 1000565.METUNv1_00623 1.23e-65 214.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,2KUYZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_326821_3 1000565.METUNv1_00622 1.65e-10 60.5 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_718012_1 1000565.METUNv1_01940 2.31e-68 210.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,2KWD2@206389|Rhodocyclales 206389|Rhodocyclales NU fimbrial biogenesis protein PilN pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_718012_2 1000565.METUNv1_01941 4.13e-129 370.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,2KW2A@206389|Rhodocyclales 206389|Rhodocyclales NU Pilus assembly protein PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_718012_3 1000565.METUNv1_01942 1.58e-99 291.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,2KWK4@206389|Rhodocyclales 206389|Rhodocyclales NU pilus assembly protein PilP pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_110608_1 338969.Rfer_2792 0.0 1279.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,4A9MX@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narG - 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_254173_1 1000565.METUNv1_01121 5.49e-134 389.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,2KVIM@206389|Rhodocyclales 206389|Rhodocyclales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) odhB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_254173_2 1000565.METUNv1_01122 4.04e-06 47.4 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUQ1@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_183942_1 1000565.METUNv1_03579 3.47e-17 79.7 COG1032@1|root,COG1032@2|Bacteria,1PK5W@1224|Proteobacteria,2VJIN@28216|Betaproteobacteria,2KVTD@206389|Rhodocyclales 206389|Rhodocyclales C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM k59_326825_1 144197.XP_008294618.1 6.58e-11 67.8 KOG4428@1|root,KOG4428@2759|Eukaryota,38H7J@33154|Opisthokonta,3BB65@33208|Metazoa,3CVR4@33213|Bilateria,485BD@7711|Chordata,49KTZ@7742|Vertebrata,4A63Z@7898|Actinopterygii 33208|Metazoa T Inositol polyphosphate-4-phosphatase, type Ia INPP4A GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006793,GO:0006796,GO:0006797,GO:0006798,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009987,GO:0016311,GO:0016312,GO:0016316,GO:0016787,GO:0016788,GO:0016791,GO:0017161,GO:0019637,GO:0019751,GO:0023052,GO:0034593,GO:0034596,GO:0036092,GO:0042578,GO:0043436,GO:0043647,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046030,GO:0046474,GO:0046486,GO:0046488,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052828,GO:0052866,GO:0065007,GO:0071704,GO:0090407,GO:0106017,GO:1901575,GO:1901576,GO:1901615 3.1.3.66 ko:K01109 ko00562,ko01100,ko04070,map00562,map01100,map04070 M00131 R04372,R07299 RC00078 ko00000,ko00001,ko00002,ko01000 - - - PH k59_538722_1 1000565.METUNv1_01317 5.93e-107 313.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2VHUX@28216|Betaproteobacteria,2KUZC@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_505368_1 748247.AZKH_4087 1.33e-17 82.8 2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,2VUB3@28216|Betaproteobacteria,2KX42@206389|Rhodocyclales 206389|Rhodocyclales S NifQ - - - ko:K15790 - - - - ko00000 - - - NifQ k59_505368_2 1538295.JY96_18355 8.15e-18 76.3 COG1146@1|root,COG1146@2|Bacteria,1QW5F@1224|Proteobacteria,2WHBY@28216|Betaproteobacteria,1KPCU@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Fer4_7 k59_1003116_1 1000565.METUNv1_02079 1.03e-32 130.0 COG1273@1|root,COG1273@2|Bacteria,1QVC4@1224|Proteobacteria,2WGPK@28216|Betaproteobacteria,2KWNJ@206389|Rhodocyclales 206389|Rhodocyclales S zinc-ribbon domain - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_1003116_2 1000565.METUNv1_02080 1.1e-69 218.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,2KUJE@206389|Rhodocyclales 206389|Rhodocyclales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_789640_1 1100720.ALKN01000045_gene289 1.83e-74 237.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria,4AAWF@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_397216_1 575590.HMPREF0156_00935 1.93e-64 209.0 arCOG14100@1|root,2Z924@2|Bacteria,4NEE9@976|Bacteroidetes 976|Bacteroidetes S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_397216_2 575590.HMPREF0156_00934 2.58e-28 112.0 COG0433@1|root,COG0433@2|Bacteria,4NI3B@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_74876_1 1123228.AUIH01000072_gene1659 9e-31 119.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1XHCG@135619|Oceanospirillales 135619|Oceanospirillales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_74876_2 930166.CD58_02700 9.79e-35 125.0 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,1S5WF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase yqiA GO:0003674,GO:0003824,GO:0016787,GO:0016788 - ko:K07000 - - - - ko00000 - - - UPF0227 k59_1039490_1 1000565.METUNv1_02405 1.59e-205 577.0 COG2114@1|root,COG2114@2|Bacteria,1QWGZ@1224|Proteobacteria,2WEJJ@28216|Betaproteobacteria,2KZV9@206389|Rhodocyclales 206389|Rhodocyclales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_110632_1 269798.CHU_1054 1.13e-85 268.0 COG3046@1|root,COG3046@2|Bacteria,4NECD@976|Bacteroidetes,47N6N@768503|Cytophagia 976|Bacteroidetes S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_1003147_1 1000565.METUNv1_00775 2.32e-83 258.0 COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,2KVEP@206389|Rhodocyclales 206389|Rhodocyclales M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_433970_1 1000565.METUNv1_03798 3.3e-131 385.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,2KV63@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1109809_1 1000565.METUNv1_01897 3.31e-105 320.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,2KUTU@206389|Rhodocyclales 206389|Rhodocyclales L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_859914_1 1000565.METUNv1_02254 1.24e-101 296.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,2KW86@206389|Rhodocyclales 206389|Rhodocyclales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_859914_2 1000565.METUNv1_02253 9.19e-120 345.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,2KUA3@206389|Rhodocyclales 206389|Rhodocyclales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_40140_1 234621.RER_43020 2.28e-43 162.0 COG3250@1|root,COG3250@2|Bacteria,2GM69@201174|Actinobacteria,4FZNM@85025|Nocardiaceae 201174|Actinobacteria G beta-mannosidase - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_326888_1 443143.GM18_0058 3.67e-24 106.0 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - DUF1566,EF-hand_5,FGE-sulfatase,Lactamase_B_2,PD40,Peptidase_S9 k59_896753_1 1304883.KI912532_gene2274 3.23e-63 209.0 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,2KVDI@206389|Rhodocyclales 206389|Rhodocyclales S transport system, permease and ATPase - - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2,ABC_tran k59_896753_2 1000565.METUNv1_03918 1.01e-08 55.5 COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2VJN9@28216|Betaproteobacteria,2KX9X@206389|Rhodocyclales 206389|Rhodocyclales S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_468101_1 543728.Vapar_6002 3.83e-14 67.4 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,2VSDU@28216|Betaproteobacteria,4ADW6@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_468101_2 1144319.PMI16_00686 2.82e-34 125.0 COG0840@1|root,COG0840@2|Bacteria,1RG1E@1224|Proteobacteria,2VRUW@28216|Betaproteobacteria,47678@75682|Oxalobacteraceae 28216|Betaproteobacteria NT methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal,PilJ k59_789663_1 700598.Niako_5689 3.82e-100 301.0 COG0137@1|root,COG0137@2|Bacteria,4NE3R@976|Bacteroidetes,1INXV@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_824798_2 1288494.EBAPG3_16930 2.59e-40 149.0 2BQTM@1|root,32JQC@2|Bacteria,1PW95@1224|Proteobacteria,2WBU8@28216|Betaproteobacteria,373TM@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_74907_1 996637.SGM_3992 1.67e-35 136.0 COG2610@1|root,COG2610@2|Bacteria,2GITQ@201174|Actinobacteria 201174|Actinobacteria EG Gluconate gnuT - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease k59_505440_1 1122951.ATUE01000008_gene257 7.84e-108 324.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,3NJSC@468|Moraxellaceae 1236|Gammaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1778,iPC815.YPO3335 Fumerase,Fumerase_C k59_184031_1 375286.mma_1311 6.23e-68 216.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,4729P@75682|Oxalobacteraceae 28216|Betaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family alaA - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_505448_1 760117.JN27_22230 1.3e-53 177.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,473AP@75682|Oxalobacteraceae 28216|Betaproteobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_326907_1 1000565.METUNv1_01516 1.24e-294 817.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KV0U@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional activator of acetoin glycerol metabolism - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_789679_1 314231.FP2506_06631 3.14e-36 130.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,2PJ0A@255475|Aurantimonadaceae 28211|Alphaproteobacteria U N-terminal TM domain of oligopeptide transport permease C dppC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_789679_2 614083.AWQR01000018_gene1917 8.4e-88 266.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4AA2A@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily dppD - - ko:K02031,ko:K12371 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_609446_1 748280.NH8B_2160 1.43e-58 200.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,2KPYV@206351|Neisseriales 206351|Neisseriales I Transporter, major facilitator family protein - - - - - - - - - - - - Acyltransferase,MFS_1 k59_718070_1 375286.mma_3363 1.52e-23 99.4 COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4725Y@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_718070_2 626418.bglu_1g03050 2.41e-46 160.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1K15K@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1076710_1 1000565.METUNv1_03992 2.45e-167 507.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971,DUF748 k59_184061_2 1000565.METUNv1_03740 1.18e-253 703.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,2VKXR@28216|Betaproteobacteria,2KVG6@206389|Rhodocyclales 206389|Rhodocyclales T Sh3 type 3 domain protein - - - - - - - - - - - - - k59_74950_1 1304883.KI912532_gene2732 1.32e-37 134.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,2KVET@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_74950_2 1304883.KI912532_gene2733 7.3e-80 244.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,2KVN7@206389|Rhodocyclales 206389|Rhodocyclales S Catalytic LigB subunit of aromatic ring-opening dioxygenase ygiD - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_1003212_1 1000565.METUNv1_03496 3.7e-58 189.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,2KW06@206389|Rhodocyclales 206389|Rhodocyclales O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1003212_2 62928.azo0024 2.31e-76 234.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VSIN@28216|Betaproteobacteria,2KX02@206389|Rhodocyclales 206389|Rhodocyclales S MobA-like NTP transferase domain - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_681476_1 1150469.RSPPHO_03274 9.29e-59 189.0 2DTV2@1|root,33MS7@2|Bacteria,1NKAB@1224|Proteobacteria 2|Bacteria - - - - - - - - - - - - - - - k59_789721_1 85643.Tmz1t_1452 2.47e-42 145.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,2KV5Z@206389|Rhodocyclales 206389|Rhodocyclales JM Nucleotidyl transferase - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_789721_2 1000565.METUNv1_03867 7.3e-56 182.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KUFJ@206389|Rhodocyclales 206389|Rhodocyclales S phosphotransferase related to Ser Thr protein kinases - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_74960_1 1238182.C882_2365 5.88e-48 169.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2JR59@204441|Rhodospirillales 204441|Rhodospirillales F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_1090752_1 1158050.KB895454_gene1250 6.52e-12 67.4 COG1643@1|root,COG1643@2|Bacteria,2GMAW@201174|Actinobacteria,1W7YU@1268|Micrococcaceae 201174|Actinobacteria L ATP-dependent helicase HrpB hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_1090752_2 1122963.AUHB01000005_gene2746 1.7e-20 91.7 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,36XI8@31993|Methylocystaceae 28211|Alphaproteobacteria F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_344763_1 1286093.C266_11066 2.64e-16 87.8 COG2831@1|root,COG2831@2|Bacteria,1MXF6@1224|Proteobacteria,2VJHW@28216|Betaproteobacteria,1K4KY@119060|Burkholderiaceae 28216|Betaproteobacteria U Hemolysin activator HlyB domain protein - - - - - - - - - - - - POTRA_2,POTRA_3,ShlB k59_201991_1 1000565.METUNv1_01569 2.75e-49 162.0 2BK8A@1|root,32ENA@2|Bacteria,1NQ7J@1224|Proteobacteria,2W50V@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_523589_1 946483.Cenrod_0229 5.13e-60 209.0 COG1002@1|root,COG1002@2|Bacteria,1MWRH@1224|Proteobacteria,2VMKD@28216|Betaproteobacteria,4ACZU@80864|Comamonadaceae 28216|Betaproteobacteria V type II restriction enzyme, methylase - - - - - - - - - - - - N6_Mtase k59_373766_1 1121015.N789_00925 6.42e-06 48.5 COG4461@1|root,COG4461@2|Bacteria,1NGDW@1224|Proteobacteria,1T4BR@1236|Gammaproteobacteria,1XDDJ@135614|Xanthomonadales 135614|Xanthomonadales S Lysozyme inhibitor LprI - - - - - - - - - - - - LprI k59_1119510_1 1198452.Jab_2c23460 1.11e-133 389.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,472ID@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_14669_1 1223521.BBJX01000004_gene2607 2.76e-56 189.0 COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2VK8I@28216|Betaproteobacteria,4AD35@80864|Comamonadaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_225601_1 745310.G432_04965 1.51e-07 58.9 COG3210@1|root,COG3468@1|root,COG4625@1|root,COG3210@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,2TSB7@28211|Alphaproteobacteria,2K2RZ@204457|Sphingomonadales 204457|Sphingomonadales U protein with a C-terminal OMP (outer membrane protein) domain - - - ko:K19231 - - - - ko00000,ko02000 1.B.12 - - Autotransporter,PATR k59_302807_1 614083.AWQR01000010_gene1613 1.03e-119 359.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,4ABP4@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM phosphoesterase, RecJ domain protein recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_14692_1 59374.Fisuc_2311 1.97e-10 61.6 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_618493_1 1353529.M899_2143 3.75e-12 64.3 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,42RT9@68525|delta/epsilon subdivisions,2MTFT@213481|Bdellovibrionales,2WNJ0@28221|Deltaproteobacteria 213481|Bdellovibrionales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_1658 Fer4_14,Radical_SAM k59_226775_1 159087.Daro_1470 4.83e-13 68.2 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,2KVEH@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_226775_2 522306.CAP2UW1_4153 3.97e-70 218.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,1KQT5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Cytochrome c oxidase assembly protein CtaG/Cox11 ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_729727_1 29581.BW37_01718 2.33e-66 231.0 COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,476AX@75682|Oxalobacteraceae 28216|Betaproteobacteria U TIGRFAM filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - ESPR,Haemagg_act k59_454749_1 1454004.AW11_03331 1.47e-63 211.0 COG1226@1|root,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria 1224|Proteobacteria P Ion transport 2 domain protein - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_454749_2 159087.Daro_1730 2.06e-44 146.0 2FHBX@1|root,34967@2|Bacteria,1P0BQ@1224|Proteobacteria,2W40F@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_692957_1 296591.Bpro_0203 3.01e-103 305.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,4A9UB@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_692957_2 614083.AWQR01000022_gene3 1.26e-37 126.0 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,4AFCT@80864|Comamonadaceae 28216|Betaproteobacteria S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_122994_1 1121957.ATVL01000006_gene2685 1.93e-06 52.0 COG3291@1|root,COG3291@2|Bacteria,4NG09@976|Bacteroidetes,47NP4@768503|Cytophagia 976|Bacteroidetes S Fungalysin metallopeptidase (M36) - - - - - - - - - - - - FTP,PA,PKD,Peptidase_M36 k59_122994_2 1191523.MROS_0708 1.89e-16 77.8 2D6MI@1|root,32TMJ@2|Bacteria 2|Bacteria S PAP2 superfamily C-terminal - - - - - - - - - - - - PAP2_C k59_267374_1 1005048.CFU_3692 3.49e-85 269.0 COG2319@1|root,COG2319@2|Bacteria,1PZS8@1224|Proteobacteria,2W29C@28216|Betaproteobacteria,477NI@75682|Oxalobacteraceae 28216|Betaproteobacteria S Wd-40 repeat - - - - - - - - - - - - - k59_692961_1 1268622.AVS7_01211 3.63e-06 45.8 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,4AEQV@80864|Comamonadaceae 28216|Betaproteobacteria S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_692961_2 1100721.ALKO01000019_gene1406 5.05e-51 166.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,4ADYP@80864|Comamonadaceae 28216|Betaproteobacteria S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_304514_1 1157708.KB907450_gene6308 8.55e-140 412.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,4A9US@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1053711_1 1120977.JHUX01000003_gene678 1e-40 143.0 2E62S@1|root,330RV@2|Bacteria,1N7P9@1224|Proteobacteria,1SHBI@1236|Gammaproteobacteria,3NIQW@468|Moraxellaceae 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_304529_1 29581.BW37_01801 1.17e-23 99.8 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,472BS@75682|Oxalobacteraceae 28216|Betaproteobacteria M NlpB/DapX lipoprotein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_304529_2 1095769.CAHF01000013_gene3163 4.99e-25 96.7 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,2VSTN@28216|Betaproteobacteria,4741Q@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_454792_1 338969.Rfer_3026 1.82e-113 338.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,4AAVV@80864|Comamonadaceae 28216|Betaproteobacteria S CBS domain containing protein - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_872860_1 56110.Oscil6304_2312 2.06e-46 164.0 COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1H75A@1150|Oscillatoriales 1117|Cyanobacteria S PFAM CBS domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_669287_2 1198452.Jab_1c02890 6.31e-46 149.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_669287_3 1198452.Jab_1c02880 4.63e-29 110.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,472Q7@75682|Oxalobacteraceae 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_159283_1 1198452.Jab_1c02780 4.47e-47 160.0 COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VJA3@28216|Betaproteobacteria,472B7@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_692995_1 504472.Slin_1835 5.53e-36 139.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47K02@768503|Cytophagia 976|Bacteroidetes S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_525980_1 614083.AWQR01000047_gene3268 1.18e-48 159.0 COG2146@1|root,COG2146@2|Bacteria 2|Bacteria P nitrite reductase [NAD(P)H] activity - - 2.7.1.3 ko:K00846,ko:K05710 ko00051,ko00360,ko01100,ko01120,ko01220,map00051,map00360,map01100,map01120,map01220 M00545 R00866,R03819,R06782,R06783 RC00002,RC00017,RC00098,RC00608 br01602,ko00000,ko00001,ko00002,ko01000,ko04147 - - - PfkB,Rieske k59_304554_2 1125701.HMPREF1221_00332 4.15e-19 84.7 COG1699@1|root,COG1699@2|Bacteria,2J7ZU@203691|Spirochaetes 203691|Spirochaetes N Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW k59_584332_1 640511.BC1002_6750 2.41e-87 270.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,1K2N3@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - ko:K06714 - - - - ko00000,ko03000 - - - HTH_8,PAS_4,Sigma54_activat k59_226821_1 640081.Dsui_1222 1.19e-109 325.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria,2KUG3@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_551166_1 349106.PsycPRwf_2230 1.2e-28 115.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,3NJF2@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 AnmK k59_481196_1 83406.HDN1F_25800 8.66e-38 130.0 COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,1S64N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_481196_2 83406.HDN1F_25790 4.92e-46 162.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4DZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_204180_1 1532557.JL37_08620 6.45e-42 147.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,3T2WP@506|Alcaligenaceae 28216|Betaproteobacteria S Belongs to the MtfA family mtfA - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_226837_1 261292.Nit79A3_3369 1.24e-78 249.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VII4@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_454855_1 504472.Slin_3090 8.42e-40 143.0 COG3183@1|root,COG3183@2|Bacteria,4NTGK@976|Bacteroidetes,47RKJ@768503|Cytophagia 976|Bacteroidetes L PFAM HNH endonuclease - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH k59_408175_1 1000565.METUNv1_02564 6.64e-33 122.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VK20@28216|Betaproteobacteria,2KZT3@206389|Rhodocyclales 206389|Rhodocyclales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_729807_1 887062.HGR_14314 5.62e-87 277.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,4A9N1@80864|Comamonadaceae 28216|Betaproteobacteria NT Signal transducing histidine kinase, homodimeric cheA GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_1091728_1 595537.Varpa_0969 3.87e-48 165.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,4A9J9@80864|Comamonadaceae 28216|Betaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_87442_1 998674.ATTE01000001_gene2230 3.79e-07 52.4 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,460KX@72273|Thiotrichales 72273|Thiotrichales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_87442_2 1000565.METUNv1_02797 1.39e-87 266.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,2KUK0@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_526065_2 1158292.JPOE01000002_gene3530 1.97e-91 271.0 COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,2VJ48@28216|Betaproteobacteria,1KJCN@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_763335_3 1007869.M9MUG9_9CAUD 2.27e-14 79.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QHVT@10662|Myoviridae 10662|Myoviridae S amidase activity - - - - - - - - - - - - - k59_347234_1 1121405.dsmv_0468 1.92e-37 140.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIF7@213118|Desulfobacterales 28221|Deltaproteobacteria U General secretion pathway protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_693082_1 1198452.Jab_2c31770 2.44e-72 230.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,473DE@75682|Oxalobacteraceae 28216|Betaproteobacteria MU TIGRFAM type I secretion outer membrane protein, TolC family tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_693082_2 1198452.Jab_2c31750 3.31e-62 192.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,4748U@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_551251_1 395495.Lcho_2410 3.39e-75 233.0 COG1879@1|root,COG1879@2|Bacteria,1MV17@1224|Proteobacteria,2VTNC@28216|Betaproteobacteria 28216|Betaproteobacteria G Periplasmic binding protein domain - - - ko:K02058 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_669439_2 614083.AWQR01000030_gene2732 7.56e-85 253.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,4ADGI@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_204270_1 373126.Q2A0C0_9VIRU 5.15e-12 73.6 4QCM6@10239|Viruses 10239|Viruses S actin binding - - - - - - - - - - - - - k59_618618_1 397945.Aave_1234 3.4e-10 65.1 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,4AB5U@80864|Comamonadaceae 28216|Betaproteobacteria T SMART Nucleotide binding protein, PINc phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_526131_1 1480694.DC28_10155 1.02e-83 259.0 COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes 203691|Spirochaetes G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_87487_1 1000565.METUNv1_02015 1.04e-196 595.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,2KVBJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_267536_1 29581.BW37_01573 9.79e-165 468.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,4739F@75682|Oxalobacteraceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_408233_1 1234364.AMSF01000058_gene848 5.08e-96 309.0 COG1196@1|root,COG1196@2|Bacteria,1R0Q9@1224|Proteobacteria,1T4NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_803268_1 1121033.AUCF01000013_gene1536 4.89e-79 243.0 COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,2TTTD@28211|Alphaproteobacteria,2JSCE@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function, DUF599 - - - - - - - - - - - - DUF599 k59_618638_1 614083.AWQR01000037_gene3457 6.22e-09 55.8 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2VMUD@28216|Betaproteobacteria,4AB2N@80864|Comamonadaceae 28216|Betaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_618638_2 614083.AWQR01000029_gene2113 2.06e-59 186.0 2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,2VYVD@28216|Betaproteobacteria 28216|Betaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_481317_1 1121033.AUCF01000001_gene2295 2.33e-113 347.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2JQPF@204441|Rhodospirillales 204441|Rhodospirillales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_408237_1 864051.BurJ1DRAFT_0459 4.85e-182 521.0 2DB95@1|root,2Z7UM@2|Bacteria,1MX5I@1224|Proteobacteria,2VMZ7@28216|Betaproteobacteria,1KND6@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_408237_2 1217718.ALOU01000002_gene4641 1.06e-13 70.9 COG1674@1|root,COG1674@2|Bacteria,1NR1U@1224|Proteobacteria,2VMUS@28216|Betaproteobacteria,1KC97@119060|Burkholderiaceae 28216|Betaproteobacteria D FtsK/SpoIIIE family - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE k59_997366_2 1244869.H261_06696 7.38e-20 87.4 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TRET@28211|Alphaproteobacteria,2JPKH@204441|Rhodospirillales 204441|Rhodospirillales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family dctA - - ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - - SDF k59_142557_1 1348657.M622_19305 7.7e-102 305.0 28HY4@1|root,2Z83J@2|Bacteria,1Q1KZ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_244434_1 883126.HMPREF9710_01223 1.54e-05 45.8 COG1639@1|root,COG4191@1|root,COG1639@2|Bacteria,COG4191@2|Bacteria,1R444@1224|Proteobacteria,2VJPB@28216|Betaproteobacteria,475CW@75682|Oxalobacteraceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - GAF,GAF_3,HATPase_c,HDOD k59_820560_1 1198452.Jab_2c18400 9.16e-16 70.5 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,474K5@75682|Oxalobacteraceae 28216|Betaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_820560_2 1349767.GJA_3357 5.73e-16 76.3 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,473NY@75682|Oxalobacteraceae 28216|Betaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1105694_1 1366050.N234_08405 7.57e-49 169.0 COG3339@1|root,COG3619@1|root,COG3339@2|Bacteria,COG3619@2|Bacteria,1NNMJ@1224|Proteobacteria,2VIM6@28216|Betaproteobacteria,1K2V4@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1275) - - - - - - - - - - - - DUF1275 k59_1105698_1 1120999.JONM01000005_gene3907 1.02e-32 125.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,2KPRY@206351|Neisseriales 206351|Neisseriales T HDOD domain - - - - - - - - - - - - EAL,HDOD k59_601383_1 1267211.KI669560_gene2760 1.24e-111 328.0 COG1235@1|root,COG1235@2|Bacteria,4NDWB@976|Bacteroidetes,1INS0@117747|Sphingobacteriia 976|Bacteroidetes S of the beta-lactamase superfamily I phnP - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_34899_1 887062.HGR_10215 2.69e-128 394.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,2VHIR@28216|Betaproteobacteria,4AA52@80864|Comamonadaceae 28216|Betaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_926035_1 857087.Metme_1979 2.37e-35 132.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,1XH1V@135618|Methylococcales 1236|Gammaproteobacteria L IS66 C-terminal element - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_926035_2 1323663.AROI01000002_gene1208 1.48e-06 48.9 COG2963@1|root,COG2963@2|Bacteria,1N7SX@1224|Proteobacteria,1SGP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_142642_1 1121920.AUAU01000010_gene61 3.82e-10 59.3 COG0500@1|root,COG2226@2|Bacteria,3Y5HG@57723|Acidobacteria 57723|Acidobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 k59_601465_2 1234364.AMSF01000033_gene430 2.64e-32 117.0 COG1765@1|root,COG1765@2|Bacteria,1PHC3@1224|Proteobacteria,1TA7C@1236|Gammaproteobacteria,1X8WZ@135614|Xanthomonadales 135614|Xanthomonadales O OsmC-like protein - - - - - - - - - - - - OsmC k59_997485_1 497964.CfE428DRAFT_4389 1.48e-24 106.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia 2|Bacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_926100_1 1123367.C666_08905 1.7e-66 219.0 COG1196@1|root,COG1196@2|Bacteria,1R4R0@1224|Proteobacteria 1224|Proteobacteria D COG0419 ATPase involved in DNA repair - - - ko:K19171 - - - - ko00000,ko02048 - - - AAA_23 k59_1140137_2 1437882.AZRU01000095_gene1240 4.22e-88 275.0 COG0600@1|root,COG1116@1|root,COG0600@2|Bacteria,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1YF59@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K02049,ko:K15578 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.17 - - ABC_tran k59_142702_1 85643.Tmz1t_1558 1.62e-56 186.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,2KURQ@206389|Rhodocyclales 206389|Rhodocyclales C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_425834_1 323261.Noc_0044 1.4e-05 53.5 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_244617_1 7460.GB41025-PA 3.11e-14 76.6 KOG1911@1|root,KOG1911@2759|Eukaryota,3A4DJ@33154|Opisthokonta,3BRD1@33208|Metazoa,3D884@33213|Bilateria,41ZRX@6656|Arthropoda,3SN0B@50557|Insecta,46I7S@7399|Hymenoptera 33208|Metazoa B Chromo (CHRromatin Organisation MOdifier) domain - - - - - - - - - - - - Chromo k59_35029_1 445961.IW15_19290 7.02e-41 146.0 COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,1HZ2G@117743|Flavobacteriia,3ZNUM@59732|Chryseobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 30 family - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_35029_2 1450525.JATV01000019_gene2401 1.3e-37 137.0 COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,1HZ2G@117743|Flavobacteriia,2NSZB@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 30 family - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_632809_2 543728.Vapar_2366 5.19e-26 101.0 2E95F@1|root,333E6@2|Bacteria,1N8N7@1224|Proteobacteria,2VWX5@28216|Betaproteobacteria,4AEYG@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3619) - - - - - - - - - - - - DUF3619 k59_926196_1 397945.Aave_3997 7.44e-53 174.0 COG3416@1|root,COG3416@2|Bacteria,1QVQQ@1224|Proteobacteria,2WH56@28216|Betaproteobacteria,4AAHQ@80864|Comamonadaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - bZIP_2 k59_601602_1 1047013.AQSP01000139_gene2394 5.08e-49 166.0 COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria 2|Bacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - DUF3318,Peptidase_M48 k59_820729_2 218491.ECA2876 2.86e-186 519.0 COG0175@1|root,COG0175@2|Bacteria,1PZ96@1224|Proteobacteria,1SBUC@1236|Gammaproteobacteria,1MRAZ@122277|Pectobacterium 1236|Gammaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_712253_1 1144275.COCOR_02593 3.04e-41 159.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - ko:K16416 ko01052,map01052 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_244709_1 1504981.KO116_4179 3.56e-21 97.8 COG1215@1|root,COG3170@1|root,COG1215@2|Bacteria,COG3170@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Cellulose synthase bcsA - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - BcsB,Cellulose_synt,Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ k59_601639_1 1158294.JOMI01000003_gene2688 7.26e-61 201.0 COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,2FPFC@200643|Bacteroidia 976|Bacteroidetes H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_712272_1 1286093.C266_15362 1e-138 403.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,1K4X3@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_781465_1 76114.ebA6267 4.57e-96 289.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,2KWZW@206389|Rhodocyclales 206389|Rhodocyclales V COG1131 ABC-type multidrug transport system, ATPase component nosF - - ko:K19340 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC_tran k59_781465_2 748247.AZKH_2412 1.23e-14 73.2 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria,2KVYI@206389|Rhodocyclales 206389|Rhodocyclales P COG3420 Nitrous oxidase accessory protein nosD - - ko:K07218 - - - - ko00000 - - - NosD k59_244758_1 596154.Alide2_1301 2.25e-69 216.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,4A9WC@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_244758_2 365046.Rta_28220 4.54e-08 53.1 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,4A9QY@80864|Comamonadaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_997695_1 864051.BurJ1DRAFT_0007 2.62e-51 172.0 COG3181@1|root,COG3181@2|Bacteria,1PGX3@1224|Proteobacteria,2W9KN@28216|Betaproteobacteria,1KNIC@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_244767_1 1000565.METUNv1_00805 2.54e-90 281.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,2KUJ4@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4 k59_997698_1 118166.JH976537_gene4474 3.36e-90 285.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1G5IK@1117|Cyanobacteria,1HEEQ@1150|Oscillatoriales 1117|Cyanobacteria C Dehydrogenase E1 component - - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_107150_1 1000565.METUNv1_00883 2.05e-133 390.0 COG5338@1|root,COG5338@2|Bacteria,1RJTK@1224|Proteobacteria,2VSP8@28216|Betaproteobacteria,2KZ1S@206389|Rhodocyclales 206389|Rhodocyclales S Putative beta-barrel porin 2 - - - - - - - - - - - - BBP2_2 k59_678232_1 1000565.METUNv1_04018 1.09e-17 81.6 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,2KZZK@206389|Rhodocyclales 206389|Rhodocyclales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_678232_2 525897.Dbac_3171 1.19e-17 84.3 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42P1P@68525|delta/epsilon subdivisions,2WJ99@28221|Deltaproteobacteria,2M8RW@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48,TAT_signal,TPR_16,TPR_19 k59_464117_1 1000565.METUNv1_02961 1.65e-105 325.0 COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,2KV3G@206389|Rhodocyclales 206389|Rhodocyclales E COG1982 Arginine lysine ornithine decarboxylases adiA - 4.1.1.19 ko:K01584 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N k59_321388_1 1198452.Jab_2c03620 1.01e-82 263.0 COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,2VMMS@28216|Betaproteobacteria 28216|Betaproteobacteria G Aamy_C - - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,CBM_20 k59_535472_1 1266925.JHVX01000003_gene685 1.46e-184 523.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,372QC@32003|Nitrosomonadales 28216|Betaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_749612_1 1000565.METUNv1_01640 7.52e-64 215.0 COG3064@1|root,COG3064@2|Bacteria,1QWHV@1224|Proteobacteria 1224|Proteobacteria M Membrane - - - - - - - - - - - - - k59_749612_2 1000565.METUNv1_01657 2.15e-22 95.5 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VHFE@28216|Betaproteobacteria,2KVID@206389|Rhodocyclales 206389|Rhodocyclales P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC k59_249987_1 1304883.KI912532_gene1862 1.24e-148 431.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,2KVK4@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_178644_1 1000565.METUNv1_01449 3.72e-150 427.0 COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,2VK09@28216|Betaproteobacteria,2KZYB@206389|Rhodocyclales 28216|Betaproteobacteria H Methylene-tetrahydromethanopterin dehydrogenase, N-terminal - - - ko:K10714 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R08059 RC00202 ko00000,ko00001,ko01000 - - - Mpt_N k59_178650_1 1000565.METUNv1_01054 3.31e-56 196.0 COG1289@1|root,COG1289@2|Bacteria,1MWR1@1224|Proteobacteria,2VJEF@28216|Betaproteobacteria,2KZHZ@206389|Rhodocyclales 206389|Rhodocyclales S FUSC-like inner membrane protein yccS - - - - - - - - - - - - FUSC-like,FUSC_2 k59_178650_2 296591.Bpro_0646 7.26e-27 106.0 COG3576@1|root,COG3576@2|Bacteria,1QTUS@1224|Proteobacteria,2VNJ5@28216|Betaproteobacteria,4ACS9@80864|Comamonadaceae 28216|Betaproteobacteria S Pfam:Pyridox_oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_249995_1 1000565.METUNv1_01834 3.08e-81 249.0 28JUE@1|root,2Z9JG@2|Bacteria,1R961@1224|Proteobacteria,2VNJ0@28216|Betaproteobacteria,2KYD6@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_821039_1 666681.M301_0511 3.59e-63 207.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KNE7@206350|Nitrosomonadales 206350|Nitrosomonadales T GAF domain - - - - - - - - - - - - GAF,HD_5 k59_428478_1 398767.Glov_3528 7.75e-30 113.0 COG0834@1|root,COG0834@2|Bacteria,1RDJ0@1224|Proteobacteria,4315G@68525|delta/epsilon subdivisions,2WX1M@28221|Deltaproteobacteria 28221|Deltaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_249999_1 1000565.METUNv1_02934 9.85e-37 127.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,2VREE@28216|Betaproteobacteria,2KWBD@206389|Rhodocyclales 206389|Rhodocyclales O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_249999_2 1000565.METUNv1_02935 2.89e-194 548.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,2KVM8@206389|Rhodocyclales 206389|Rhodocyclales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_392752_1 1000565.METUNv1_00339 3.09e-272 758.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,2KUEF@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_321427_1 426114.THI_2914 4.12e-132 387.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KJ33@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_1106566_1 887062.HGR_04633 1.15e-99 298.0 COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,4AB1B@80864|Comamonadaceae 28216|Betaproteobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase trxB2 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_1070952_1 926550.CLDAP_35510 5.23e-05 45.1 COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi 200795|Chloroflexi EGP Major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_3 k59_178671_1 1125973.JNLC01000015_gene3312 2.7e-11 62.8 COG0508@1|root,COG0596@1|root,COG0508@2|Bacteria,COG0596@2|Bacteria,1QWX5@1224|Proteobacteria,2TX7D@28211|Alphaproteobacteria,3K0XI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_178671_2 78245.Xaut_4044 6.84e-88 268.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,3EY87@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain - - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_678261_1 1000565.METUNv1_01844 1.25e-32 119.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2VIX4@28216|Betaproteobacteria,2KUB2@206389|Rhodocyclales 206389|Rhodocyclales S Urea ABC transporter ATP-binding protein urtd urtD - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_678261_2 1000565.METUNv1_01845 4.2e-59 187.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,2KV7I@206389|Rhodocyclales 206389|Rhodocyclales E ABC transporter, ATP-binding protein urtE - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_1035223_1 1131814.JAFO01000001_gene1700 1.77e-54 182.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,3EYMU@335928|Xanthobacteraceae 28211|Alphaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_642663_1 1000565.METUNv1_00864 1.46e-82 249.0 295CM@1|root,2ZSQM@2|Bacteria,1PA63@1224|Proteobacteria,2W6CW@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_928093_1 1100720.ALKN01000028_gene2532 7.91e-100 297.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,4ACAC@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator rbcR - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_214278_1 1154860.SAG0136_11345 2.7e-20 88.6 28J2E@1|root,2Z8YX@2|Bacteria,1TRF9@1239|Firmicutes,4HD03@91061|Bacilli 91061|Bacilli S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_178682_1 159087.Daro_2198 3.14e-77 241.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,2KU8Y@206389|Rhodocyclales 206389|Rhodocyclales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_178682_2 1300350.DSW25_11495 3.68e-08 53.5 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,3ZW97@60136|Sulfitobacter 28211|Alphaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_821055_1 1000565.METUNv1_03646 1.95e-80 243.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_714008_1 1397527.Q670_03110 7e-125 385.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_178690_2 1121939.L861_07145 1.32e-58 191.0 COG0583@1|root,COG0583@2|Bacteria,1MW8C@1224|Proteobacteria,1S0C4@1236|Gammaproteobacteria,1XHF1@135619|Oceanospirillales 135619|Oceanospirillales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_535508_1 1000565.METUNv1_02913 7.66e-102 299.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,2KW1M@206389|Rhodocyclales 206389|Rhodocyclales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_535508_3 1000565.METUNv1_02915 1.06e-92 302.0 COG2304@1|root,COG2374@1|root,COG2304@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,2VK7U@28216|Betaproteobacteria,2KY0R@206389|Rhodocyclales 206389|Rhodocyclales Q Endonuclease/Exonuclease/phosphatase family - - - ko:K07004 - - - - ko00000 - - - Exo_endo_phos k59_357127_1 1196322.A370_05624 1.46e-15 78.2 COG5002@1|root,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24ZB0@186801|Clostridia,36QRP@31979|Clostridiaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_357127_2 935863.AWZR01000001_gene1552 6.46e-18 78.6 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,1S4GM@1236|Gammaproteobacteria,1X8ZK@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein CheY - - - - - - - - - - - - Response_reg k59_250018_1 1000565.METUNv1_00838 5.91e-77 252.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KV2V@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_250018_2 1000565.METUNv1_00839 1.11e-67 206.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,2KWPI@206389|Rhodocyclales 206389|Rhodocyclales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_250018_3 1000565.METUNv1_00840 2.54e-154 441.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,2KVRT@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_785413_1 1000565.METUNv1_01883 2.05e-183 519.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,2KUGY@206389|Rhodocyclales 206389|Rhodocyclales S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_285713_2 76114.ebA2840 8.27e-106 316.0 COG0846@1|root,COG0846@2|Bacteria,1QA4R@1224|Proteobacteria,2VHMN@28216|Betaproteobacteria,2KUUM@206389|Rhodocyclales 206389|Rhodocyclales K COG0846 NAD-dependent protein deacetylases, SIR2 family - - - - - - - - - - - - SIR2 k59_285713_3 1000565.METUNv1_02017 5.39e-51 167.0 2ATZM@1|root,31JJE@2|Bacteria,1RIFX@1224|Proteobacteria,2VSS3@28216|Betaproteobacteria,2KWZ4@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_79824_1 365046.Rta_20050 7.54e-91 286.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAYN@80864|Comamonadaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase NAD-binding fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1112989_1 1000565.METUNv1_02270 7.26e-29 109.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,2KVIT@206389|Rhodocyclales 206389|Rhodocyclales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1112989_4 1000565.METUNv1_02267 4.81e-13 67.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,2KVE2@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_863849_1 1122951.ATUE01000006_gene1157 4.85e-36 124.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,3NNG8@468|Moraxellaceae 1236|Gammaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_863849_2 83406.HDN1F_10580 2.67e-26 97.8 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_863849_3 1046625.AFQY01000002_gene1616 3.82e-27 103.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,3NISA@468|Moraxellaceae 1236|Gammaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_1112991_1 1000565.METUNv1_03581 3.76e-139 410.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2W9QE@28216|Betaproteobacteria,2KZ9H@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_401282_2 640081.Dsui_1216 6.72e-73 221.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,2KW2N@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - - - - - - - - - - tRNA_edit k59_794020_1 614083.AWQR01000038_gene1395 1.09e-28 108.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,4AB4P@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_794020_2 614083.AWQR01000038_gene1394 1.18e-74 224.0 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2VT0P@28216|Betaproteobacteria,4ADXB@80864|Comamonadaceae 28216|Betaproteobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_7781_1 243233.MCA0657 4.26e-52 185.0 COG1203@1|root,COG1713@1|root,COG1203@2|Bacteria,COG1713@2|Bacteria,1MX7A@1224|Proteobacteria,1RQBR@1236|Gammaproteobacteria,1XE50@135618|Methylococcales 135618|Methylococcales L Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD k59_655540_1 991905.SL003B_3516 1.6e-54 189.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_721609_1 1198452.Jab_1c00970 6.92e-06 46.6 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,472AY@75682|Oxalobacteraceae 28216|Betaproteobacteria U Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_721609_2 1198452.Jab_1c00980 2.18e-98 293.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,472A9@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC-type multidrug transport system, ATPase component ybhF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_190988_1 653045.Strvi_7745 1.7e-131 395.0 COG4626@1|root,COG4626@2|Bacteria,2IB7D@201174|Actinobacteria 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_114540_2 706587.Desti_5049 1.74e-13 75.1 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2MS09@213462|Syntrophobacterales 28221|Deltaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_577694_1 1123487.KB892835_gene3329 6.97e-79 250.0 COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2VK8I@28216|Betaproteobacteria,2KUGN@206389|Rhodocyclales 206389|Rhodocyclales E Binding-protein-dependent transport system inner membrane component - - - ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_901553_1 688270.Celal_1591 4.85e-08 60.1 COG1361@1|root,COG1506@1|root,COG3291@1|root,COG3405@1|root,COG3693@1|root,COG4932@1|root,COG1361@2|Bacteria,COG1506@2|Bacteria,COG3291@2|Bacteria,COG3405@2|Bacteria,COG3693@2|Bacteria,COG4932@2|Bacteria,4NDZC@976|Bacteroidetes,1IKB7@117743|Flavobacteriia 976|Bacteroidetes M Domain of unknown function DUF11 - - - - - - - - - - - - CHU_C,DUF11 k59_512356_1 1209072.ALBT01000023_gene3978 1.37e-38 137.0 COG5285@1|root,COG5285@2|Bacteria,1RC3C@1224|Proteobacteria,1S4A7@1236|Gammaproteobacteria,1FI5U@10|Cellvibrio 1236|Gammaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_441278_1 397945.Aave_2208 5.52e-64 207.0 COG2301@1|root,COG2301@2|Bacteria,1Q91U@1224|Proteobacteria,2VJJY@28216|Betaproteobacteria,4AAAQ@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the HpcH HpaI aldolase family citE - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_863880_1 279238.Saro_3003 7.94e-67 223.0 28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,2TST4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_794058_2 322710.Avin_44300 3.62e-97 291.0 COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,1S0QF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_512375_1 1000565.METUNv1_00876 3.73e-109 321.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VHAW@28216|Betaproteobacteria,2KVG1@206389|Rhodocyclales 206389|Rhodocyclales I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases tsaR - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_829994_1 1000565.METUNv1_03816 3.17e-103 308.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,2KUCX@206389|Rhodocyclales 206389|Rhodocyclales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1113022_2 1000565.METUNv1_00062 1.28e-106 314.0 29AFQ@1|root,2ZXFW@2|Bacteria,1RGFB@1224|Proteobacteria,2VQD0@28216|Betaproteobacteria,2KYP8@206389|Rhodocyclales 206389|Rhodocyclales S Transcription factor zinc-finger - - - - - - - - - - - - zf-TFIIB k59_441307_1 266835.14024852 2.51e-26 109.0 COG0412@1|root,COG0412@2|Bacteria,1R5J6@1224|Proteobacteria,2UE6V@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dienelactone hydrolase - - - - - - - - - - - - DLH,Peptidase_S9 k59_830003_1 232721.Ajs_4103 6.53e-67 217.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,4AAEX@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_830003_2 338969.Rfer_0374 0.000647 41.2 COG0583@1|root,COG0583@2|Bacteria,1QYAP@1224|Proteobacteria,2VHXD@28216|Betaproteobacteria,4ABRM@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, LysR family - - - ko:K21699 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_295083_1 264198.Reut_A3368 5.96e-111 326.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2VIR5@28216|Betaproteobacteria,1K0HC@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_333743_1 1268622.AVS7_02393 5.12e-25 98.2 2D113@1|root,32T9N@2|Bacteria,1N3N7@1224|Proteobacteria,2VTZS@28216|Betaproteobacteria,4AHME@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_333743_2 83406.HDN1F_07160 1.91e-44 152.0 COG2253@1|root,COG2253@2|Bacteria,1PZRM@1224|Proteobacteria,1S18R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_7832_1 76114.ebA838 1.17e-106 321.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KURK@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_655632_1 305700.B447_05168 4.44e-42 150.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,2KVCM@206389|Rhodocyclales 206389|Rhodocyclales NU twitching motility protein - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_333749_1 596153.Alide_2695 4.98e-163 486.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_333749_2 596153.Alide_2708 5.8e-18 82.4 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria 28216|Betaproteobacteria S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_79891_1 1268622.AVS7_02634 4.41e-15 70.1 COG3313@1|root,COG3313@2|Bacteria,1N711@1224|Proteobacteria,2VW2B@28216|Betaproteobacteria,4AE63@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3717) - - - ko:K06938 - - - - ko00000 - - - DUF1289,DUF3717 k59_79891_2 232721.Ajs_4027 2.7e-77 234.0 COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,4ABM5@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM YaeQ family protein yaeQ - - - - - - - - - - - YaeQ k59_901609_1 614083.AWQR01000029_gene2073 3.31e-56 186.0 COG0859@1|root,COG0859@2|Bacteria,1PRP7@1224|Proteobacteria,2VMYH@28216|Betaproteobacteria,4AG62@80864|Comamonadaceae 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_901609_2 1276756.AUEX01000024_gene41 1.08e-88 270.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,4A9S3@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_934765_2 1000565.METUNv1_00660 1.12e-78 256.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - 4HB_MCP_1,CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_7,PAS_8,PAS_9,Response_reg k59_473568_1 153948.NAL212_2874 2.64e-37 144.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,371Z5@32003|Nitrosomonadales 28216|Betaproteobacteria T SMART Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_402325_1 1122194.AUHU01000005_gene1106 0.000706 41.2 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,466BN@72275|Alteromonadaceae 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iEC042_1314.EC042_2517,iSbBS512_1146.SbBS512_E2652 Proton_antipo_M k59_402325_2 399739.Pmen_2424 2.23e-48 169.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1YEWN@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iEC042_1314.EC042_2517,iSbBS512_1146.SbBS512_E2652 Proton_antipo_M k59_722622_1 1000565.METUNv1_00147 1.07e-155 442.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,2KUQH@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_722622_2 1122619.KB892335_gene933 4.7e-07 50.8 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2VRGP@28216|Betaproteobacteria,3T3VY@506|Alcaligenaceae 28216|Betaproteobacteria K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_1085915_1 395495.Lcho_4212 2.36e-50 181.0 COG3852@1|root,COG5002@1|root,COG3852@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VKT5@28216|Betaproteobacteria,1KPCY@119065|unclassified Burkholderiales 28216|Betaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9 k59_613014_1 1502852.FG94_04646 1.8e-34 127.0 COG2885@1|root,COG2885@2|Bacteria,1REH1@1224|Proteobacteria,2VRF2@28216|Betaproteobacteria,476Y7@75682|Oxalobacteraceae 28216|Betaproteobacteria M Domain of unknown function (DUF4398) - - - - - - - - - - - - DUF4398,OmpA k59_971404_1 614083.AWQR01000047_gene3277 3.17e-46 166.0 COG2202@1|root,COG4585@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,COG5002@2|Bacteria,1N1PW@1224|Proteobacteria,2VU49@28216|Betaproteobacteria 28216|Betaproteobacteria T histidine kinase, dimerisation and phosphoacceptor region - - - - - - - - - - - - HATPase_c,HisKA_3 k59_296419_1 543728.Vapar_3922 5.5e-57 189.0 COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,4ABH2@80864|Comamonadaceae 28216|Betaproteobacteria S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_296419_2 420662.Mpe_A0782 3.78e-15 74.7 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,1KJED@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Amidohydrolase family atzB - 3.5.4.32 ko:K18456 - - - - ko00000,ko01000 - - - Amidohydro_1 k59_151454_1 1189620.AJXL01000031_gene2739 2.04e-18 85.1 COG1816@1|root,COG1816@2|Bacteria,4NG5W@976|Bacteroidetes,1IIAJ@117743|Flavobacteriia,2NSQD@237|Flavobacterium 976|Bacteroidetes F adenosine add - 3.5.4.4 ko:K01488,ko:K19572 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_402335_2 1031711.RSPO_c02351 1.55e-53 174.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,1K2IF@119060|Burkholderiaceae 28216|Betaproteobacteria K Iron-sulfur cluster assembly transcription factor iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_613023_2 85643.Tmz1t_0065 5.17e-07 54.3 2DBQ4@1|root,2ZABV@2|Bacteria,1R8WU@1224|Proteobacteria,2VP1M@28216|Betaproteobacteria,2KZK8@206389|Rhodocyclales 206389|Rhodocyclales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_543417_1 1000565.METUNv1_01076 0.0 955.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_543417_2 1000565.METUNv1_00991 1.68e-189 541.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_543417_3 981369.JQMJ01000004_gene2316 7.75e-16 76.6 COG2197@1|root,COG2197@2|Bacteria,2GIXB@201174|Actinobacteria,2NEEZ@228398|Streptacidiphilus 201174|Actinobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_578626_4 1500894.JQNN01000001_gene3749 2.27e-97 295.0 COG5265@1|root,COG5265@2|Bacteria,1MWU5@1224|Proteobacteria,2VHDB@28216|Betaproteobacteria 28216|Betaproteobacteria O HPr kinase - - - - - - - - - - - - - k59_578626_5 864051.BurJ1DRAFT_3199 2.15e-105 322.0 28JAH@1|root,2Z95A@2|Bacteria,1MXKT@1224|Proteobacteria,2VI69@28216|Betaproteobacteria,1KMZ7@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 k59_578626_6 1000565.METUNv1_02381 3.11e-78 238.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,2KUHS@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1044281_1 296591.Bpro_3227 2.91e-64 199.0 COG0589@1|root,COG0589@2|Bacteria,1NDDA@1224|Proteobacteria,2VUKE@28216|Betaproteobacteria,4AI33@80864|Comamonadaceae 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_971429_1 522306.CAP2UW1_3441 2.44e-20 89.4 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,1KQEF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_971429_2 1249627.D779_2005 9.49e-15 71.2 COG1366@1|root,COG1366@2|Bacteria,1N8B6@1224|Proteobacteria,1SGMB@1236|Gammaproteobacteria,1WZN4@135613|Chromatiales 135613|Chromatiales T PFAM Sulphate transporter antisigma-factor antagonist STAS - - - - - - - - - - - - STAS_2 k59_193000_1 580332.Slit_1395 2.21e-15 77.0 COG2202@1|root,COG3447@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44WDA@713636|Nitrosomonadales 28216|Betaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF,MASE1,PAS_3,PAS_9 k59_193000_2 614083.AWQR01000030_gene2753 7.03e-81 248.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VIST@28216|Betaproteobacteria,4AARE@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_80768_1 640081.Dsui_3065 1.96e-121 356.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_115720_2 864073.HFRIS_005528 2.47e-53 181.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2VNY1@28216|Betaproteobacteria,473K7@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase regB - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_514305_1 864563.HMPREF9166_1126 1.45e-57 198.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,Radical_SAM k59_722668_1 1304885.AUEY01000071_gene109 4.49e-37 140.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,42P0H@68525|delta/epsilon subdivisions,2WJK7@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_402365_1 1123255.JHYS01000017_gene1414 1e-79 259.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,4A9K5@80864|Comamonadaceae 28216|Betaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_367292_1 1005048.CFU_2496 3.97e-59 194.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,473KE@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_865169_1 164757.Mjls_4988 1.81e-22 90.9 2D8VC@1|root,32TS1@2|Bacteria,2IMXY@201174|Actinobacteria,23A2A@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_380395_1 700598.Niako_5539 2.72e-47 168.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - 5_nucleotid_C,HemolysinCabind,Laminin_G_3,VCBS k59_556411_2 1122211.JMLW01000009_gene1407 1.02e-24 100.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1XH8Y@135619|Oceanospirillales 135619|Oceanospirillales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_733772_2 614083.AWQR01000005_gene1132 1.79e-56 181.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,4ACGN@80864|Comamonadaceae 28216|Betaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_461771_1 1437882.AZRU01000211_gene2718 2.83e-13 67.8 COG4382@1|root,COG4382@2|Bacteria,1N7CA@1224|Proteobacteria,1SECS@1236|Gammaproteobacteria,1YK3G@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF1018) - - - - - - - - - - - - DUF1018 k59_163583_1 1385517.N800_06735 0.000331 48.9 COG3087@1|root,COG3087@2|Bacteria,1PI1K@1224|Proteobacteria,1T6BU@1236|Gammaproteobacteria,1XB7I@135614|Xanthomonadales 135614|Xanthomonadales D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_533426_1 266264.Rmet_0024 1.89e-69 224.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2VN2I@28216|Betaproteobacteria,1K659@119060|Burkholderiaceae 28216|Betaproteobacteria M Peptidase family M28 cgp - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_877736_1 1038869.AXAN01000008_gene4920 5.39e-05 42.0 COG3847@1|root,COG3847@2|Bacteria 2|Bacteria U Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap k59_733789_1 1163617.SCD_n02305 4.21e-40 148.0 COG1538@1|root,COG1538@2|Bacteria,1R744@1224|Proteobacteria,2VJW4@28216|Betaproteobacteria 28216|Betaproteobacteria MU PFAM Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_556444_1 1392540.P256_01017 1e-149 430.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,3NIY6@468|Moraxellaceae 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - iJN746.PP_1177 Ribonuc_red_sm k59_92184_1 1198452.Jab_2c31480 2.04e-57 189.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,472ZB@75682|Oxalobacteraceae 28216|Betaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase nasD - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_92184_2 640512.BC1003_1357 5.86e-34 130.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KG4U@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_588188_1 745310.G432_03490 3.1e-69 231.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QUPD@1224|Proteobacteria,2TW3N@28211|Alphaproteobacteria,2K28S@204457|Sphingomonadales 204457|Sphingomonadales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7,Pyr_redox_2,Pyr_redox_3,cNMP_binding k59_676633_1 999541.bgla_1g28090 9.96e-11 60.8 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1JZNK@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_676633_2 204773.HEAR0744 2.59e-58 199.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,4730T@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase family M3 prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_807483_1 748247.AZKH_1221 5.73e-71 221.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,2KUXZ@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_982691_1 522306.CAP2UW1_0615 4.1e-55 182.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1KPRK@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V ATP-binding protein ybhF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_982691_2 795666.MW7_3291 1.78e-43 149.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,1JZYY@119060|Burkholderiaceae 28216|Betaproteobacteria V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_621810_1 1268622.AVS7_03862 8.77e-132 387.0 COG1961@1|root,COG1961@2|Bacteria,1MV0C@1224|Proteobacteria,2VIRY@28216|Betaproteobacteria 28216|Betaproteobacteria L Recombinase - - - - - - - - - - - - Recombinase,Resolvase k59_767113_2 329726.AM1_2389 5.54e-12 65.9 COG1846@1|root,COG1846@2|Bacteria,1G6G4@1117|Cyanobacteria 1117|Cyanobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 k59_230712_1 1000565.METUNv1_02495 3.1e-165 478.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,2KUSZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1020936_1 360910.BAV1306 1.02e-25 105.0 2EB84@1|root,3358M@2|Bacteria,1N7EA@1224|Proteobacteria,2VWD8@28216|Betaproteobacteria,3T70Z@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_982701_1 477974.Daud_0246 5.22e-30 113.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,260SK@186807|Peptococcaceae 186801|Clostridia E TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_163642_2 1980924.B2ZYK2_9CAUD 4.26e-12 68.2 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_163642_3 1097668.BYI23_B004770 2.27e-06 51.6 28IJ1@1|root,2Z8K0@2|Bacteria,1R5PC@1224|Proteobacteria,2W0IK@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_354734_1 614083.AWQR01000005_gene1045 4.65e-78 243.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,4AAK8@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_588207_1 1127692.HMPREF9075_01964 3.5e-48 166.0 COG1083@1|root,COG1083@2|Bacteria,4NM98@976|Bacteroidetes,1I17Z@117743|Flavobacteriia 976|Bacteroidetes M Cytidylyltransferase - - 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 - R01117,R04215 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3 k59_588207_2 1168067.JAGP01000001_gene1335 2.45e-43 152.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,45ZV0@72273|Thiotrichales 72273|Thiotrichales M NeuB family - - 2.5.1.101,2.5.1.56,2.5.1.97 ko:K01654,ko:K15898,ko:K18430 ko00520,ko01100,map00520,map01100 - R01804,R04435,R09841,R10304 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_842992_1 543728.Vapar_4585 1.76e-134 418.0 COG0553@1|root,COG1787@1|root,COG0553@2|Bacteria,COG1787@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,4ABAD@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM SNF2-related protein - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - DUF3670,Helicase_C,Mrr_cat,SNF2_N k59_767128_1 795666.MW7_1016 7.61e-50 159.0 2EIXK@1|root,33CNU@2|Bacteria,1NJGK@1224|Proteobacteria,2VYGE@28216|Betaproteobacteria,1KEYP@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_767128_2 795666.MW7_1015 2.39e-56 182.0 COG1100@1|root,COG1100@2|Bacteria,1N5QS@1224|Proteobacteria,2VJJ9@28216|Betaproteobacteria,1K6E6@119060|Burkholderiaceae 28216|Betaproteobacteria S AAA domain - - - - - - - - - - - - AAA_24 k59_877782_1 925409.KI911562_gene1982 2.91e-88 289.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,4NFKH@976|Bacteroidetes,1IP8F@117747|Sphingobacteriia 976|Bacteroidetes E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_877783_1 349521.HCH_01530 8e-12 71.2 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_877783_2 1088721.NSU_0588 2.22e-22 92.0 COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,2UCGB@28211|Alphaproteobacteria,2KBEW@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2 k59_412276_1 497964.CfE428DRAFT_0776 1.43e-111 343.0 COG0613@1|root,COG0613@2|Bacteria 2|Bacteria Q PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - DUF5001,PHP k59_20795_1 946077.W5A_02395 3.19e-12 65.5 COG1277@1|root,COG1277@2|Bacteria,4NGGR@976|Bacteroidetes,1HXF5@117743|Flavobacteriia 976|Bacteroidetes S nitrous oxide - - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2,ABC2_membrane_5 k59_20795_2 945713.IALB_0859 4.85e-27 105.0 2DTQQ@1|root,33MAW@2|Bacteria 2|Bacteria S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_210517_1 1121035.AUCH01000004_gene418 2.13e-27 110.0 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,2KUEH@206389|Rhodocyclales 206389|Rhodocyclales P Anion-transporting ATPase arsA - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase,CbiA k59_210517_2 1163617.SCD_n02179 8.33e-71 218.0 COG2913@1|root,COG2913@2|Bacteria,1RM59@1224|Proteobacteria,2VSG5@28216|Betaproteobacteria 28216|Betaproteobacteria J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_210517_3 1304883.KI912532_gene798 8.6e-40 142.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KUSD@206389|Rhodocyclales 206389|Rhodocyclales KT Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_697382_2 1496688.ER33_08640 5.68e-61 197.0 COG0330@1|root,COG0330@2|Bacteria,1G34Q@1117|Cyanobacteria 1117|Cyanobacteria O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_556538_1 1121870.AUAA01000005_gene1043 7.48e-20 87.0 COG0596@1|root,COG0596@2|Bacteria,4PKKR@976|Bacteroidetes,1IJBZ@117743|Flavobacteriia,3HIHJ@358033|Chryseobacterium 976|Bacteroidetes S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6,UPF0227 k59_556538_2 1122605.KB893643_gene707 2.64e-22 96.3 COG0681@1|root,COG0681@2|Bacteria,4NFTP@976|Bacteroidetes,1IRAK@117747|Sphingobacteriia 976|Bacteroidetes U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_697400_1 358220.C380_05395 1.51e-16 78.2 COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,2VKME@28216|Betaproteobacteria,4ABF4@80864|Comamonadaceae 28216|Betaproteobacteria O TIGRFAM Xanthine dehydrogenase accessory protein XdhC xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_912847_1 595460.RRSWK_06835 8.34e-16 82.0 COG0323@1|root,COG0323@2|Bacteria,2IXI2@203682|Planctomycetes 203682|Planctomycetes L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_807578_1 614083.AWQR01000011_gene2384 1.4e-81 252.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VHMS@28216|Betaproteobacteria,4ABPG@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_556571_2 1000565.METUNv1_00052 7.26e-61 189.0 COG2201@1|root,COG2201@2|Bacteria 2|Bacteria NT protein-glutamate methylesterase activity - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_163741_1 698440.XP_007294064.1 2.55e-84 264.0 COG0265@1|root,KOG0096@1|root,KOG0096@2759|Eukaryota,KOG3129@2759|Eukaryota,38BBN@33154|Opisthokonta,3NW2J@4751|Fungi,3QPIC@4890|Ascomycota,20VZN@147548|Leotiomycetes 4751|Fungi U GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle GSP1 GO:0000054,GO:0000166,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005085,GO:0005087,GO:0005088,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006403,GO:0006405,GO:0006406,GO:0006606,GO:0006611,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0006997,GO:0007346,GO:0008104,GO:0008150,GO:0008152,GO:0008536,GO:0009889,GO:0009987,GO:0010389,GO:0010467,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010972,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016021,GO:0016043,GO:0016070,GO:0016072,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016973,GO:0017016,GO:0017038,GO:0017076,GO:0017111,GO:0019001,GO:0019219,GO:0019222,GO:0019899,GO:0022613,GO:0023052,GO:0031123,GO:0031125,GO:0031224,GO:0031267,GO:0031323,GO:0031326,GO:0031503,GO:0031935,GO:0031938,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033043,GO:0033044,GO:0033365,GO:0033750,GO:0034470,GO:0034504,GO:0034613,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042254,GO:0042886,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045184,GO:0045786,GO:0045930,GO:0046483,GO:0046907,GO:0048519,GO:0048523,GO:0050657,GO:0050658,GO:0050789,GO:0050794,GO:0051020,GO:0051028,GO:0051128,GO:0051168,GO:0051169,GO:0051170,GO:0051171,GO:0051179,GO:0051234,GO:0051236,GO:0051252,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0051726,GO:0060255,GO:0060968,GO:0065007,GO:0065009,GO:0070727,GO:0071166,GO:0071426,GO:0071427,GO:0071428,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901360,GO:1901363,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902275,GO:1902749,GO:1902750,GO:1903506,GO:2000112,GO:2001141 - ko:K07936 ko03008,ko03013,ko05166,ko05169,map03008,map03013,map05166,map05169 - - - ko00000,ko00001,ko03009,ko03016,ko03019,ko03036,ko04031,ko04147 - - - Ras k59_1021048_2 1134474.O59_002723 1.16e-27 107.0 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S92R@1236|Gammaproteobacteria,1FH7J@10|Cellvibrio 1236|Gammaproteobacteria S Serine aminopeptidase, S33 - - - ko:K07018 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4,Peptidase_S15,Thioesterase k59_354910_1 1192124.LIG30_3608 9.78e-48 170.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K1AF@119060|Burkholderiaceae 28216|Betaproteobacteria T histidine kinase HAMP region domain protein - - - ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,TarH,sCache_2 k59_676843_1 1121937.AUHJ01000001_gene478 3.34e-37 145.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,4645X@72275|Alteromonadaceae 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1094657_1 700598.Niako_0731 3.87e-60 210.0 COG4206@1|root,COG4206@2|Bacteria,4NHTX@976|Bacteroidetes,1IRJA@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_354933_1 1123073.KB899241_gene3157 5.27e-13 73.9 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1X345@135614|Xanthomonadales 135614|Xanthomonadales U General secretion pathway protein xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1124804_1 1123487.KB892868_gene1238 5.51e-08 56.6 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2W8ZR@28216|Betaproteobacteria,2KYIZ@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_412353_1 870187.Thini_1618 8.34e-42 152.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,45ZV0@72273|Thiotrichales 72273|Thiotrichales M NeuB family - - 2.5.1.101,2.5.1.56,2.5.1.97 ko:K01654,ko:K15898,ko:K18430 ko00520,ko01100,map00520,map01100 - R01804,R04435,R09841,R10304 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_912885_1 1461577.CCMH01000053_gene772 6.47e-110 330.0 COG0520@1|root,COG0520@2|Bacteria,4NDUB@976|Bacteroidetes,1HWSI@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1060938_1 1123278.KB893542_gene5569 0.00067 48.5 COG0793@1|root,COG0793@2|Bacteria,4NFKJ@976|Bacteroidetes,47MG1@768503|Cytophagia 976|Bacteroidetes M PFAM Peptidase S41 - - - - - - - - - - - - PDZ,PDZ_2,Peptidase_S41 k59_272490_1 748247.AZKH_3505 1.39e-19 85.9 COG0583@1|root,COG0583@2|Bacteria,1QU1H@1224|Proteobacteria,2VIC7@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_272490_2 748247.AZKH_3504 7.41e-26 102.0 COG4336@1|root,COG4336@2|Bacteria,1MW52@1224|Proteobacteria,2VJUJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the D-glutamate cyclase family - - - - - - - - - - - - DUF1445 k59_533723_1 614083.AWQR01000002_gene3008 5.55e-13 67.4 COG2199@1|root,COG2771@1|root,COG2771@2|Bacteria,COG3706@2|Bacteria,1QWNG@1224|Proteobacteria,2WH3C@28216|Betaproteobacteria,4AJW5@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_354965_1 1100720.ALKN01000045_gene48 7.78e-27 114.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,4A9TX@80864|Comamonadaceae 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_877913_1 859657.RPSI07_mp1391 1.47e-66 214.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,1K0VA@119060|Burkholderiaceae 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_22503_1 1504672.669783832 7.1e-109 322.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,4AB3G@80864|Comamonadaceae 28216|Betaproteobacteria S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_413899_1 1121035.AUCH01000009_gene940 4.16e-34 122.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,2KZTU@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_413899_2 522306.CAP2UW1_1141 5.12e-26 102.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1KQY9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_232276_1 365044.Pnap_0867 8.2e-92 280.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,4A9IZ@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1126603_1 697282.Mettu_1576 1.46e-57 206.0 COG0689@1|root,COG0823@1|root,COG2202@1|root,COG2304@1|root,COG2931@1|root,COG3188@1|root,COG3210@1|root,COG3898@1|root,COG4932@1|root,COG0689@2|Bacteria,COG0823@2|Bacteria,COG2202@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3188@2|Bacteria,COG3210@2|Bacteria,COG3898@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XFUS@135618|Methylococcales 135618|Methylococcales QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347 k59_22523_1 929713.NIASO_15515 1.94e-15 80.1 COG1158@1|root,COG1158@2|Bacteria,4NEFP@976|Bacteroidetes,1IPNZ@117747|Sphingobacteriia 976|Bacteroidetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_809256_1 1323663.AROI01000009_gene3839 2.21e-36 142.0 2CERA@1|root,33EN3@2|Bacteria,1NPCT@1224|Proteobacteria,1SITV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_914450_1 335283.Neut_1408 3.16e-41 157.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,372U8@32003|Nitrosomonadales 28216|Betaproteobacteria S TamB, inner membrane protein subunit of TAM complex tamB - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_94256_1 85643.Tmz1t_3599 3.36e-140 410.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,2VW7U@28216|Betaproteobacteria,2KZ23@206389|Rhodocyclales 206389|Rhodocyclales V Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_914463_1 1000565.METUNv1_01082 1.79e-245 684.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_914468_1 1232683.ADIMK_1598 1.28e-126 369.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,4641K@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70 sigma32) rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_879713_1 1000565.METUNv1_02528 1.92e-36 138.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2VJF3@28216|Betaproteobacteria,2KW03@206389|Rhodocyclales 206389|Rhodocyclales L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_879713_2 1000565.METUNv1_02529 3.88e-73 244.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,2KUW5@206389|Rhodocyclales 206389|Rhodocyclales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_129552_1 864069.MicloDRAFT_00003340 1.77e-78 243.0 COG0583@1|root,COG0583@2|Bacteria,1MUIX@1224|Proteobacteria,2TT9N@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03576 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_213323_1 397945.Aave_2383 3.45e-169 568.0 COG0454@1|root,COG0503@1|root,COG0827@1|root,COG0456@2|Bacteria,COG0503@2|Bacteria,COG0827@2|Bacteria,1PE9Y@1224|Proteobacteria,2VP0T@28216|Betaproteobacteria,4AGXR@80864|Comamonadaceae 28216|Betaproteobacteria K Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis - - - - - - - - - - - - - k59_143933_1 1000565.METUNv1_02546 1.15e-107 314.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2VJG8@28216|Betaproteobacteria,2KVYQ@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_644192_1 1000565.METUNv1_01400 1.12e-96 291.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,2KU8U@206389|Rhodocyclales 206389|Rhodocyclales F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_644192_2 1000565.METUNv1_01399 1.64e-13 63.9 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KXCI@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_715255_1 365044.Pnap_0998 2.23e-60 202.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,4A9YV@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family urtB - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_501423_1 1121921.KB898706_gene3031 1.03e-15 74.7 COG1403@1|root,COG1403@2|Bacteria,1RIBS@1224|Proteobacteria,1S88N@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Bacteriophage Lambda NinG protein - - - - - - - - - - - - NinG k59_215163_1 272560.BPSS2046 2.71e-69 215.0 COG3316@1|root,COG3316@2|Bacteria,1MZ9N@1224|Proteobacteria,2W1KY@28216|Betaproteobacteria,1K182@119060|Burkholderiaceae 28216|Betaproteobacteria L DDE domain - - - ko:K07498 - - - - ko00000 - - - DDE_Tnp_IS240 k59_1037106_1 1538295.JY96_18750 3.72e-51 175.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,1KK9D@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nitrogenase cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_1037106_2 395495.Lcho_1405 1.42e-30 108.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VVW7@28216|Betaproteobacteria,1KMHD@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S binding domain fdxN - - - - - - - - - - - Fer4,Fer4_10 k59_1037106_3 269482.Bcep1808_5996 1.56e-11 61.2 COG0316@1|root,COG0316@2|Bacteria,1N011@1224|Proteobacteria,2VUD1@28216|Betaproteobacteria,1K7R6@119060|Burkholderiaceae 28216|Betaproteobacteria S HesB YadR YfhF-family protein hesB - - - - - - - - - - - Fe-S_biosyn k59_751170_1 1144319.PMI16_01976 1.16e-116 345.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2WEZH@28216|Betaproteobacteria 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_858093_2 1000565.METUNv1_03529 1.88e-50 169.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2VHMH@28216|Betaproteobacteria,2KUA9@206389|Rhodocyclales 206389|Rhodocyclales M NeuB family - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_894301_1 390235.PputW619_1188 3.45e-40 141.0 COG3386@1|root,COG3386@2|Bacteria,1R5NQ@1224|Proteobacteria,1SYE1@1236|Gammaproteobacteria,1YY1Q@136845|Pseudomonas putida group 1236|Gammaproteobacteria G PFAM SMP-30 Gluconolaconase LRE domain protein - - - - - - - - - - - - SGL k59_894301_2 1123487.KB892864_gene2230 5.88e-07 51.2 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKC6@28216|Betaproteobacteria,2KYXC@206389|Rhodocyclales 206389|Rhodocyclales G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_1108137_1 1185876.BN8_03026 3.15e-48 175.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,47Y7H@768503|Cytophagia 976|Bacteroidetes H TonB-dependent Receptor Plug - - - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_323887_1 1000565.METUNv1_02122 5.22e-09 56.6 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,2KUT7@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase yfhK - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_323887_2 305700.B447_07352 3.64e-07 53.1 COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,2KWJR@206389|Rhodocyclales 206389|Rhodocyclales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_1037109_1 223283.PSPTO_3060 4.93e-49 167.0 COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,1RN2R@1236|Gammaproteobacteria,1Z750@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E ABC transporter, ATP-binding protein - - 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran k59_1001111_1 1000565.METUNv1_02751 2.78e-125 360.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,2KV8C@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_715996_1 1000565.METUNv1_00650 6.34e-101 302.0 COG1397@1|root,COG1397@2|Bacteria,1MXJP@1224|Proteobacteria,2VNAC@28216|Betaproteobacteria,2KZI2@206389|Rhodocyclales 206389|Rhodocyclales O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_787395_1 1304275.C41B8_04626 8.86e-48 168.0 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1S3JR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Nucleoside-diphosphate-sugar epimerase - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_787395_2 322710.Avin_44240 1.79e-169 483.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide JD73_00825 - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_215735_1 1000565.METUNv1_04036 3.4e-82 259.0 COG0811@1|root,COG0811@2|Bacteria,1N2RJ@1224|Proteobacteria,2VM7W@28216|Betaproteobacteria 28216|Betaproteobacteria U Mota tolq exbb proton channel exbB3 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - DUF2341,Laminin_G_3,MotA_ExbB k59_215735_2 1000565.METUNv1_04035 2.1e-135 388.0 COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,2VKYT@28216|Betaproteobacteria,2KU8I@206389|Rhodocyclales 206389|Rhodocyclales J COG0564 Pseudouridylate synthases, 23S RNA-specific - - 5.4.99.26 ko:K06175 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_2 k59_608066_1 987059.RBXJA2T_11897 5.37e-45 159.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,1KJF3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Alkyl hydroperoxide reductase ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_608066_2 1000565.METUNv1_01274 3.55e-79 238.0 COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,2WFVC@28216|Betaproteobacteria,2KX0H@206389|Rhodocyclales 206389|Rhodocyclales S Copper resistance protein D - - - - - - - - - - - - CopD k59_608066_3 1000565.METUNv1_01273 2.61e-30 114.0 COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,2KW4N@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_430898_1 420662.Mpe_A0943 2.75e-240 682.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,1KK7I@119065|unclassified Burkholderiales 28216|Betaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1108144_1 194699.Q775D4_BPBPP 2.07e-97 334.0 4QHMX@10239|Viruses,4QW8C@35237|dsDNA viruses no RNA stage,4QRQS@28883|Caudovirales,4QNWI@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_502437_1 1000565.METUNv1_02471 1.14e-116 343.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,2KVN9@206389|Rhodocyclales 206389|Rhodocyclales S Permease YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_37725_3 762376.AXYL_04054 1.05e-61 198.0 2CI1J@1|root,32S73@2|Bacteria,1N528@1224|Proteobacteria,2VYZ1@28216|Betaproteobacteria,3T65K@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_751187_1 1000565.METUNv1_02777 8.38e-76 230.0 COG0328@1|root,COG0328@2|Bacteria,1RJZT@1224|Proteobacteria,2VSDS@28216|Betaproteobacteria,2KXBT@206389|Rhodocyclales 206389|Rhodocyclales L Reverse transcriptase-like - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 k59_287617_1 1123255.JHYS01000010_gene452 4.67e-90 290.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAP6@80864|Comamonadaceae 28216|Betaproteobacteria V Transporter, hydrophobe amphiphile efflux-1 (HAE1) family acrB - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_108790_1 700598.Niako_6573 7.01e-48 161.0 COG0457@1|root,COG0457@2|Bacteria,4NQ40@976|Bacteroidetes,1IT6C@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 k59_645175_1 1000565.METUNv1_01388 1.43e-168 478.0 COG0827@1|root,COG0827@2|Bacteria,1QP3Z@1224|Proteobacteria,2VI9V@28216|Betaproteobacteria,2KVWP@206389|Rhodocyclales 206389|Rhodocyclales L Eco57I restriction-modification methylase - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I k59_894336_2 1000565.METUNv1_00202 3.5e-74 232.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,2KUDX@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_502456_1 1000565.METUNv1_03228 3.68e-109 323.0 COG0075@1|root,COG0075@2|Bacteria,1PM38@1224|Proteobacteria,2VHNM@28216|Betaproteobacteria,2KVAR@206389|Rhodocyclales 206389|Rhodocyclales E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase - - - - - - - - - - - - Aminotran_5 k59_1037143_1 748247.AZKH_1666 1.42e-42 142.0 COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2VVQN@28216|Betaproteobacteria,2KXFH@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_679718_1 78245.Xaut_1342 2.87e-174 506.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TR3I@28211|Alphaproteobacteria,3F1C9@335928|Xanthobacteraceae 28211|Alphaproteobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_465898_1 1198452.Jab_2c25960 3.58e-96 307.0 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,2WC0M@28216|Betaproteobacteria,476TB@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_858132_1 1122243.KB903810_gene1217 4.54e-104 305.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,3NIGB@468|Moraxellaceae 1236|Gammaproteobacteria C succinate dehydrogenase sdhB GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765 Fer2_3,Fer4_17,Fer4_8 k59_1879_1 1000565.METUNv1_01306 0.0 984.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,2KUXJ@206389|Rhodocyclales 206389|Rhodocyclales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1001149_1 1198452.Jab_1c07950 3.01e-114 330.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,4745N@75682|Oxalobacteraceae 28216|Betaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_108809_1 768671.ThimaDRAFT_2192 5.57e-41 150.0 COG4643@1|root,COG4643@2|Bacteria,1N08G@1224|Proteobacteria,1RTFA@1236|Gammaproteobacteria,1WW3C@135613|Chromatiales 135613|Chromatiales T Protein of unknown function (DUF3987) - - - - - - - - - - - - DUF3987 k59_108809_2 323848.Nmul_A0060 1.69e-43 147.0 COG0358@1|root,COG0358@2|Bacteria,1PETP@1224|Proteobacteria,2W6UH@28216|Betaproteobacteria,374HV@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA primase activity - - - - - - - - - - - - - k59_716040_1 502025.Hoch_2554 1.09e-22 102.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2YXI4@29|Myxococcales 68525|delta/epsilon subdivisions T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_716040_2 930166.CD58_27730 5.85e-59 195.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - iYL1228.KPN_02462 AdoHcyase,AdoHcyase_NAD k59_679724_2 1000565.METUNv1_01193 8.08e-128 377.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,2VQY3@28216|Betaproteobacteria,2KXFS@206389|Rhodocyclales 206389|Rhodocyclales NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl,PilW k59_37757_1 1000565.METUNv1_01195 3.52e-173 527.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KUTC@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_679725_1 748247.AZKH_4193 6.35e-05 47.0 COG0840@1|root,COG0840@2|Bacteria,1NCMF@1224|Proteobacteria,2VJC0@28216|Betaproteobacteria,2KW4V@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_679725_2 582744.Msip34_2714 1.11e-31 114.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2VSKU@28216|Betaproteobacteria 28216|Betaproteobacteria T Pfam Response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_536984_1 748247.AZKH_1427 1.38e-28 118.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,2KUJB@206389|Rhodocyclales 206389|Rhodocyclales N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_287659_1 697282.Mettu_1059 3.73e-58 185.0 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S24N@1236|Gammaproteobacteria,1XF7B@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF1993) - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_394745_1 257310.BB2343 5.31e-45 157.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2VJQC@28216|Betaproteobacteria,3T6RD@506|Alcaligenaceae 28216|Betaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_822751_1 1000565.METUNv1_00433 3.31e-29 109.0 COG3235@1|root,COG3235@2|Bacteria,1RDMZ@1224|Proteobacteria,2WFSM@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - - - - - - - - - - - k59_108826_1 748247.AZKH_0020 1.6e-66 213.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,2KW0A@206389|Rhodocyclales 206389|Rhodocyclales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.29,3.6.3.30 ko:K02010,ko:K02017,ko:K02052 ko02010,ko02024,map02010,map02024 M00189,M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11,3.A.1.8 - - ABC_tran,TOBE_2 k59_1001171_1 1122605.KB893625_gene2314 1.85e-63 208.0 COG0827@1|root,COG0827@2|Bacteria,4PNBZ@976|Bacteroidetes 976|Bacteroidetes L DNA restriction-modification system - - - - - - - - - - - - - k59_608113_2 279714.FuraDRAFT_1970 5.47e-65 201.0 COG4101@1|root,COG4101@2|Bacteria,1RIHD@1224|Proteobacteria,2VT14@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_181095_2 1000565.METUNv1_03864 3.34e-28 107.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,2M03T@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulatory protein, C terminal - - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_536990_2 1000565.METUNv1_00335 2.13e-74 224.0 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,2VU2S@28216|Betaproteobacteria,2KX34@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_430972_1 1000565.METUNv1_02995 2.96e-90 288.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,2KUC6@206389|Rhodocyclales 206389|Rhodocyclales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_37776_1 420662.Mpe_A0899 3.42e-36 132.0 COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,2VKQT@28216|Betaproteobacteria 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_37776_3 748247.AZKH_2009 1.23e-42 141.0 2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,2VWDQ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1001179_1 164328.Phyra73458 2.6e-21 97.8 KOG0580@1|root,KOG0580@2759|Eukaryota,3QCDX@4776|Peronosporales 4776|Peronosporales T Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_929353_1 640081.Dsui_0672 1.67e-113 342.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales 206389|Rhodocyclales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1108204_1 1235457.C404_18225 7.44e-56 186.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1MX32@1224|Proteobacteria,2WB2J@28216|Betaproteobacteria,1K50N@119060|Burkholderiaceae 28216|Betaproteobacteria T GAF domain - - - - - - - - - - - - GAF_2,GGDEF k59_72927_2 1286093.C266_21934 8.42e-31 112.0 2ARMM@1|root,31GY9@2|Bacteria,1QUYR@1224|Proteobacteria,2WGKY@28216|Betaproteobacteria,1K7KC@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1854) - - - - - - - - - - - - DUF1854 k59_288430_1 1121035.AUCH01000008_gene1122 6.28e-58 196.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales 206389|Rhodocyclales U Type 4 fimbrial biogenesis protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_537541_1 1244869.H261_16341 1.46e-118 380.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2770@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,dCache_1 k59_867270_1 85643.Tmz1t_3265 2.1e-29 121.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,2VJKQ@28216|Betaproteobacteria,2KV2F@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_867270_2 1163617.SCD_n02984 6.09e-121 354.0 COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,2VHT7@28216|Betaproteobacteria 28216|Betaproteobacteria GM Transport permease protein - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_758880_1 1500281.JQKZ01000003_gene1711 3.5e-11 63.5 COG0618@1|root,COG0618@2|Bacteria,4NEXE@976|Bacteroidetes,1HX3D@117743|Flavobacteriia,3ZNMZ@59732|Chryseobacterium 976|Bacteroidetes S DHH family nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_153798_1 1042375.AFPL01000032_gene866 2.95e-12 71.6 2DPGA@1|root,331YB@2|Bacteria,1N7RM@1224|Proteobacteria,1SE00@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1115893_1 1000565.METUNv1_00189 5.96e-135 383.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,2KW52@206389|Rhodocyclales 206389|Rhodocyclales F Deoxynucleoside kinase - - - - - - - - - - - - dNK k59_1115893_2 1000565.METUNv1_00190 1.52e-06 47.0 COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2VSWS@28216|Betaproteobacteria,2KWRH@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09922 - - - - ko00000 - - - DMT_6 k59_117598_1 669262.COK_0691 1.74e-06 52.0 2C58H@1|root,32YYI@2|Bacteria,1N7UA@1224|Proteobacteria,1S81E@1236|Gammaproteobacteria,1Y965@135625|Pasteurellales 135625|Pasteurellales S NinB protein - - - - - - - - - - - - NinB k59_117598_2 1392540.P256_00051 3.47e-18 80.1 2A1G0@1|root,30PPF@2|Bacteria,1R9RR@1224|Proteobacteria,1TN8P@1236|Gammaproteobacteria,3NQ6A@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF968 k59_662902_1 85643.Tmz1t_3304 9.96e-39 133.0 COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,2KX1I@206389|Rhodocyclales 206389|Rhodocyclales S cobalamin (vitamin B12) biosynthesis CbiX protein - - 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiX k59_404865_1 159087.Daro_0835 2.83e-44 145.0 2EB0P@1|root,330T4@2|Bacteria,1QAEY@1224|Proteobacteria,2VWEP@28216|Betaproteobacteria,2M035@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_83739_1 596154.Alide2_3751 1.17e-161 469.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,4AARI@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_798989_1 596154.Alide2_0748 9.31e-80 259.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,4AA7Z@80864|Comamonadaceae 28216|Betaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1047132_1 1000565.METUNv1_01015 5.2e-40 134.0 COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,2VSRW@28216|Betaproteobacteria,2KWZQ@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09959 - - - - ko00000 - - - DUF779 k59_1047132_2 1000565.METUNv1_00784 1.06e-136 399.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,2KUMA@206389|Rhodocyclales 206389|Rhodocyclales E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_118883_1 204773.HEAR2435 1.94e-59 187.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VRKC@28216|Betaproteobacteria,4740W@75682|Oxalobacteraceae 28216|Betaproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_118883_2 883126.HMPREF9710_03518 1.16e-31 121.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,4723N@75682|Oxalobacteraceae 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_519430_1 640081.Dsui_2453 4.39e-86 257.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,2KUG9@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_798995_2 218491.ECA1389 8.51e-38 137.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1MRK0@122277|Pectobacterium 1236|Gammaproteobacteria M Male sterility protein galE GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0003978,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901575,GO:1901576 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1139,iSF_1195.SF0545,iSFxv_1172.SFxv_0601,iS_1188.S0553,iYL1228.KPN_00773 Epimerase,GDP_Man_Dehyd k59_299838_1 1198452.Jab_1c16710 1.09e-06 47.0 COG0484@1|root,COG0484@2|Bacteria,1PXN1@1224|Proteobacteria,2WCG8@28216|Betaproteobacteria,477J9@75682|Oxalobacteraceae 28216|Betaproteobacteria O DnaJ molecular chaperone homology domain - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ k59_299838_2 1198452.Jab_1c16720 1.56e-84 251.0 2A7IB@1|root,30WG3@2|Bacteria,1PI53@1224|Proteobacteria,2W6R3@28216|Betaproteobacteria,47752@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_759959_1 398527.Bphyt_2719 9.76e-20 91.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VPAC@28216|Betaproteobacteria,1K3CV@119060|Burkholderiaceae 28216|Betaproteobacteria T chemotaxis - - - ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_615348_1 1000565.METUNv1_03451 5.27e-112 326.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VJQ0@28216|Betaproteobacteria,2KUCD@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_662951_1 29581.BW37_03577 2.11e-26 100.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,4740G@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS - - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_662951_2 398767.Glov_0178 2.26e-25 103.0 COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42S1Y@68525|delta/epsilon subdivisions,2WP4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria K AraC-type transcriptional regulator - - - - - - - - - - - - AraC_N,HTH_18 k59_1012342_1 1236959.BAMT01000004_gene903 2.75e-49 162.0 2E2GR@1|root,32XKS@2|Bacteria,1N41X@1224|Proteobacteria,2VUN3@28216|Betaproteobacteria,2KKWG@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_1012344_1 338969.Rfer_1643 2.5e-105 312.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,4A9RA@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_662961_1 1250005.PHEL85_2925 1.58e-56 181.0 COG0740@1|root,COG0740@2|Bacteria,4NE20@976|Bacteroidetes,1HWT0@117743|Flavobacteriia,3VVAQ@52959|Polaribacter 976|Bacteroidetes OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_662961_2 443255.SCLAV_3924 1.38e-06 50.1 COG2885@1|root,COG2885@2|Bacteria,2HXT6@201174|Actinobacteria 201174|Actinobacteria M Belongs to the ompA family oprF - - - - - - - - - - - OmpA k59_938404_1 1123393.KB891333_gene2623 2.54e-80 245.0 28KE4@1|root,2ZA0D@2|Bacteria,1MXZT@1224|Proteobacteria,2VNI6@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_725999_1 85643.Tmz1t_1205 1.32e-18 85.9 COG1639@1|root,COG1639@2|Bacteria,1R4P9@1224|Proteobacteria,2VPZE@28216|Betaproteobacteria,2KW2Y@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction protein - - - - - - - - - - - - HDOD k59_725999_2 1122602.ATXP01000015_gene1214 1.87e-07 53.1 COG0007@1|root,COG0007@2|Bacteria,2GK3B@201174|Actinobacteria,1W93A@1268|Micrococcaceae 201174|Actinobacteria H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase k59_371096_1 1000565.METUNv1_03900 3.1e-92 305.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,2KUFW@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_938422_1 1255043.TVNIR_1463 1.75e-21 99.0 COG1332@1|root,COG3064@1|root,COG1332@2|Bacteria,COG3064@2|Bacteria,1REN1@1224|Proteobacteria 1224|Proteobacteria L TIGRFAM CRISPR-associated RAMP protein, Csm5 family - - - ko:K19140 - - - - ko00000,ko02048 - - - RAMPs k59_83806_1 1500894.JQNN01000001_gene2789 5.04e-62 214.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,473KU@75682|Oxalobacteraceae 28216|Betaproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_974371_1 153721.MYP_2894 3.85e-39 140.0 COG3637@1|root,COG3637@2|Bacteria,4NE33@976|Bacteroidetes,47NZ9@768503|Cytophagia 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_1012385_1 1304885.AUEY01000020_gene3476 2.31e-27 106.0 2C96H@1|root,2Z7Q6@2|Bacteria,1PQG4@1224|Proteobacteria 1224|Proteobacteria S Sulfotransferase raxST - - ko:K13472 ko04626,map04626 - - - ko00000,ko00001 - - - Sulfotransfer_3 k59_1012385_2 349521.HCH_06167 2.97e-22 94.0 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1XJE0@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_615394_1 393595.ABO_2500 3.88e-32 126.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1XIMN@135619|Oceanospirillales 135619|Oceanospirillales MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_938439_1 269798.CHU_0111 6.75e-66 218.0 COG0173@1|root,COG0173@2|Bacteria,4NECY@976|Bacteroidetes,47JC8@768503|Cytophagia 976|Bacteroidetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_118951_1 296591.Bpro_5572 1.29e-11 67.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria,4ADA8@80864|Comamonadaceae 28216|Betaproteobacteria L Transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_118951_2 261292.Nit79A3_3228 1.33e-09 62.4 2DPZY@1|root,3345E@2|Bacteria,1NC0H@1224|Proteobacteria,2W5ZJ@28216|Betaproteobacteria,3747H@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_118951_3 1217652.F954_01645 0.000224 42.7 COG0500@1|root,COG2226@2|Bacteria,1PH2I@1224|Proteobacteria,1S03T@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 k59_663053_1 1502852.FG94_00398 2.23e-89 281.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VHHU@28216|Betaproteobacteria,478IG@75682|Oxalobacteraceae 28216|Betaproteobacteria O Collagenase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_448692_1 1282362.AEAC466_12180 4e-07 57.4 COG4772@1|root,COG4772@2|Bacteria,1MVMV@1224|Proteobacteria,2TWFY@28211|Alphaproteobacteria,2KG8S@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1117135_2 1129794.C427_0411 5.83e-22 91.7 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,1S2Z2@1236|Gammaproteobacteria,466WX@72275|Alteromonadaceae 1236|Gammaproteobacteria Q dithiol-disulfide isomerase involved in polyketide biosynthesis - - - - - - - - - - - - DSBA k59_118968_1 887062.HGR_14634 3.5e-91 283.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,4AA59@80864|Comamonadaceae 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_404948_1 1000565.METUNv1_00185 2.96e-158 448.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VHCI@28216|Betaproteobacteria,2KV44@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_118975_1 983917.RGE_14010 2.06e-21 98.2 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,1KPMM@119065|unclassified Burkholderiales 28216|Betaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K11527,ko:K20973 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_299937_1 933262.AXAM01000021_gene459 6.2e-35 137.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MJZH@213118|Desulfobacterales 28221|Deltaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_546850_1 1000565.METUNv1_01896 9.61e-89 276.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW1@206389|Rhodocyclales 206389|Rhodocyclales JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_974403_1 1000565.METUNv1_00184 2.81e-312 874.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,2KUAW@206389|Rhodocyclales 206389|Rhodocyclales E aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_83849_1 1000565.METUNv1_00374 3.04e-133 403.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KUIP@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_48688_1 1541065.JRFE01000017_gene160 3.03e-28 112.0 COG1409@1|root,COG1409@2|Bacteria,1GBIP@1117|Cyanobacteria 1117|Cyanobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_581185_1 1071679.BG57_17895 5.32e-118 364.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae 28216|Betaproteobacteria L dna topoisomerase III topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_448728_1 365046.Rta_33250 8.65e-61 203.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,4ABFF@80864|Comamonadaceae 28216|Betaproteobacteria S SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_476945_1 1198452.Jab_2c17950 3.9e-110 318.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,473NH@75682|Oxalobacteraceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1117157_1 85643.Tmz1t_1321 3.87e-36 129.0 COG1871@1|root,COG1871@2|Bacteria,1RI55@1224|Proteobacteria,2VUAC@28216|Betaproteobacteria,2KWWX@206389|Rhodocyclales 206389|Rhodocyclales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_1117157_2 1198452.Jab_1c06610 5.4e-12 65.1 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,4776Y@75682|Oxalobacteraceae 28216|Betaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR1 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_118994_1 1000565.METUNv1_02687 1.22e-152 434.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,2KUG2@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_371185_1 1198452.Jab_1c06420 1.04e-70 216.0 COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2VRFS@28216|Betaproteobacteria,474PC@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix ASNC type - - - ko:K05800 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_340883_1 1454007.JAUG01000009_gene1988 1.7e-80 249.0 COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,1IPUF@117747|Sphingobacteriia 976|Bacteroidetes G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_938484_1 1000565.METUNv1_00082 2.69e-72 222.0 2BWQ4@1|root,32QZV@2|Bacteria,1MZQ9@1224|Proteobacteria,2VSNR@28216|Betaproteobacteria,2KWKW@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_299962_1 1158292.JPOE01000002_gene2329 1.61e-42 149.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2VNHE@28216|Betaproteobacteria,1KMMF@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_299962_2 1158292.JPOE01000002_gene2330 1.43e-37 139.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria,1KIT1@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_519635_1 1121920.AUAU01000016_gene1356 3.1e-56 196.0 COG0841@1|root,COG0841@2|Bacteria,3Y31D@57723|Acidobacteria 57723|Acidobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_519635_2 682795.AciX8_0391 1.85e-09 57.8 COG0841@1|root,COG0841@2|Bacteria,3Y3GP@57723|Acidobacteria,2JIJD@204432|Acidobacteriia 204432|Acidobacteriia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_546884_2 755732.Fluta_2381 1.41e-111 326.0 COG3279@1|root,COG3279@2|Bacteria,4NNHE@976|Bacteroidetes,1HZAH@117743|Flavobacteriia,2PATW@246874|Cryomorphaceae 976|Bacteroidetes K Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_663150_1 1000565.METUNv1_02127 6.55e-07 51.2 2EHSE@1|root,33BI5@2|Bacteria,1NIWY@1224|Proteobacteria 1224|Proteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_663150_2 864051.BurJ1DRAFT_2155 1.81e-132 381.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria 28216|Betaproteobacteria NU NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_1047359_2 1000565.METUNv1_01011 3.01e-19 87.0 2C4IG@1|root,2Z8A1@2|Bacteria,1QTHZ@1224|Proteobacteria,2VJBR@28216|Betaproteobacteria,2KV8B@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_12328_1 1094466.KQS_05220 4.95e-16 80.9 29ZGM@1|root,30MGC@2|Bacteria,4NNY9@976|Bacteroidetes,1I2DF@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_155313_1 1267211.KI669560_gene1306 1.22e-61 194.0 COG0127@1|root,COG0127@2|Bacteria,4NM42@976|Bacteroidetes,1IRYX@117747|Sphingobacteriia 976|Bacteroidetes F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_155313_2 700598.Niako_4699 6.76e-66 205.0 COG1595@1|root,COG1595@2|Bacteria,4NQCH@976|Bacteroidetes,1ISH7@117747|Sphingobacteriia 976|Bacteroidetes K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_689111_2 292415.Tbd_2082 2.43e-06 53.5 2DMII@1|root,32RTH@2|Bacteria 2|Bacteria S CHRD domain - - - - - - - - - - - - CHRD,VPEP k59_1047367_1 338969.Rfer_1360 3.43e-54 182.0 COG4643@1|root,COG4643@2|Bacteria,1R5M0@1224|Proteobacteria,2VPIH@28216|Betaproteobacteria,4AAT3@80864|Comamonadaceae 28216|Betaproteobacteria S Toprim domain - - - ko:K06919 - - - - ko00000 - - - DUF3631,Toprim_3,Toprim_4 k59_615463_1 1005048.CFU_2639 1.51e-71 224.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VIWR@28216|Betaproteobacteria 28216|Betaproteobacteria ET Amino acid ABC transporter substrate-binding protein - - - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_155326_1 29581.BW37_01900 2.69e-99 311.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,473C8@75682|Oxalobacteraceae 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_615467_1 595537.Varpa_5066 1.41e-56 193.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria,4ACZX@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fcs - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding k59_1024871_1 1000565.METUNv1_01526 6.53e-08 53.1 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,2KV1X@206389|Rhodocyclales 206389|Rhodocyclales G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_1024871_2 1000565.METUNv1_01519 2.01e-31 117.0 COG5501@1|root,COG5501@2|Bacteria,1RBHP@1224|Proteobacteria,2VR7Y@28216|Betaproteobacteria,2KXWK@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ - - - - - - - - - - - - SoxY,SoxZ k59_275971_1 1207076.ALAT01000100_gene2608 2.71e-36 137.0 COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,1YZUA@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate pdxB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.290 ko:K03473 ko00750,ko01100,map00750,map01100 M00124 R04210 RC00084 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z3582 2-Hacid_dh,2-Hacid_dh_C,DUF3410 k59_915912_1 1198452.Jab_2c30040 2.61e-80 251.0 2BIMR@1|root,32CUQ@2|Bacteria,1PZNT@1224|Proteobacteria,2WAM9@28216|Betaproteobacteria,473D6@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - DUF2863 k59_60384_1 1123393.KB891316_gene1231 5.68e-38 133.0 2E1J6@1|root,32WWW@2|Bacteria,1N539@1224|Proteobacteria,2VWBY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_96077_2 1175306.GWL_23330 2.74e-63 198.0 2DBG4@1|root,2Z927@2|Bacteria,1N7I6@1224|Proteobacteria,2VQ2P@28216|Betaproteobacteria,473T4@75682|Oxalobacteraceae 28216|Betaproteobacteria K Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways flhC - - ko:K02402 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlhC k59_1024889_1 631362.Thi970DRAFT_04800 7.17e-80 257.0 28HN3@1|root,2Z7WH@2|Bacteria,1MWH8@1224|Proteobacteria,1RYMP@1236|Gammaproteobacteria,1WXH2@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - ko:K19117 - - - - ko00000,ko02048 - - - Cas_Csd1 k59_737060_2 1502852.FG94_03996 4.53e-20 84.7 2A9IK@1|root,32Q64@2|Bacteria,1PV4S@1224|Proteobacteria,2WB38@28216|Betaproteobacteria,474W0@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1096871_1 1123504.JQKD01000005_gene4945 1.23e-61 203.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2VKSJ@28216|Betaproteobacteria,4ACTJ@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_276012_1 1046714.AMRX01000006_gene3143 4.62e-42 140.0 2CJFJ@1|root,32S9X@2|Bacteria,1N1UV@1224|Proteobacteria,1SBPY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_24133_1 1000565.METUNv1_01355 6.71e-172 493.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,2KVUQ@206389|Rhodocyclales 206389|Rhodocyclales C 24 kD subunit - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_560869_1 236097.ADG881_653 1.13e-29 118.0 COG2067@1|root,COG2067@2|Bacteria,1RA6W@1224|Proteobacteria,1RPD8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG2067 Long-chain fatty acid transport protein - - - - - - - - - - - - Toluene_X k59_560869_2 1380387.JADM01000002_gene1923 3.78e-14 74.7 28S27@1|root,2ZEE0@2|Bacteria,1RAGA@1224|Proteobacteria,1S3DZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 k59_131345_1 1122951.ATUE01000007_gene616 5.95e-93 277.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,3NJYC@468|Moraxellaceae 1236|Gammaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_1128424_1 1317118.ATO8_14607 1.24e-09 56.2 COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,4KN3E@93682|Roseivivax 28211|Alphaproteobacteria S Protein of unknown function (DUF465) MA20_03740 - - - - - - - - - - - DUF465 k59_131349_1 640081.Dsui_0574 1.59e-102 308.0 COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KU8X@206389|Rhodocyclales 206389|Rhodocyclales C FAD dependent oxidoreductase - - - ko:K00313 - - - - ko00000,ko01000 - - - FAD_binding_3 k59_490754_1 1121033.AUCF01000006_gene4244 5.91e-59 192.0 COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2TR99@28211|Alphaproteobacteria,2JPQ6@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_490754_2 1121033.AUCF01000006_gene4245 8.61e-39 137.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TSIQ@28211|Alphaproteobacteria,2JR00@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_701051_2 159087.Daro_3214 4.93e-89 281.0 COG1765@1|root,COG1944@1|root,COG1765@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,2VHZY@28216|Betaproteobacteria,2KV2Z@206389|Rhodocyclales 206389|Rhodocyclales O redox protein, regulator of disulfide bond formation - - - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO k59_560902_1 1000565.METUNv1_02014 2.28e-46 155.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - 3.4.21.107 ko:K04771,ko:K07126 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - Cu_amine_oxidN1,Trypsin_2,YceG_bac k59_560905_1 395019.Bmul_4433 4.74e-44 160.0 COG1409@1|root,COG1409@2|Bacteria,1R8W7@1224|Proteobacteria,2VJ1Q@28216|Betaproteobacteria,1K1XV@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM metallophosphoesterase - - - - - - - - - - - - Metallophos k59_701067_1 44689.DDB0237857 3.68e-36 140.0 COG0659@1|root,KOG4660@1|root,KOG0236@2759|Eukaryota,KOG4660@2759|Eukaryota,3XEU6@554915|Amoebozoa 554915|Amoebozoa U STAS domain - - - - - - - - - - - - STAS,Sulfate_transp k59_591424_1 640081.Dsui_0129 1.57e-87 273.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales 206389|Rhodocyclales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_624662_1 555500.I215_08381 3.25e-07 50.4 COG2824@1|root,COG2824@2|Bacteria,4NEFZ@976|Bacteroidetes,1I01B@117743|Flavobacteriia 976|Bacteroidetes P PhnA protein phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_624662_2 1406840.Q763_11555 2.66e-75 239.0 COG1538@1|root,COG1538@2|Bacteria,4NDZK@976|Bacteroidetes,1HYPG@117743|Flavobacteriia,2NTH4@237|Flavobacterium 976|Bacteroidetes MU RND transporter - - - - - - - - - - - - OEP k59_490800_1 1000565.METUNv1_00011 4.3e-81 247.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VSS4@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_737146_1 1636270.A0A0E3GMA9_9CAUD 2.37e-32 122.0 4QHKD@10239|Viruses,4QQVX@28883|Caudovirales,4QNWT@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1025014_1 391735.Veis_2882 3.03e-16 75.9 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2VRCB@28216|Betaproteobacteria,4AAJY@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - - - - - - - - - - DctQ k59_1025014_2 397945.Aave_2018 1.41e-97 298.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,4ABNC@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - DctM k59_233764_1 580332.Slit_2607 1.69e-87 271.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VJ2Y@28216|Betaproteobacteria,44VCJ@713636|Nitrosomonadales 28216|Betaproteobacteria NU PFAM Type II secretion system F domain pilC3 - - ko:K02455,ko:K12278 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_948518_1 1173023.KE650771_gene2709 4.26e-36 131.0 COG0012@1|root,COG0012@2|Bacteria,1G1PW@1117|Cyanobacteria,1JI9E@1189|Stigonemataceae 1117|Cyanobacteria J Protein of unknown function (DUF933) ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_986469_1 1346330.M472_06995 1.96e-31 124.0 COG1680@1|root,COG1680@2|Bacteria,4NFMQ@976|Bacteroidetes,1IQ1K@117747|Sphingobacteriia 976|Bacteroidetes V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1025025_1 93220.LV28_24760 6.31e-50 172.0 COG3497@1|root,COG3497@2|Bacteria,1R3SE@1224|Proteobacteria,2VPMY@28216|Betaproteobacteria,1KAZJ@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage tail sheath protein subtilisin-like domain - - - ko:K06907 - - - - ko00000 - - - - k59_1025025_3 1144342.PMI40_01687 4e-23 98.2 2BV62@1|root,32QJE@2|Bacteria,1RM1Z@1224|Proteobacteria,2VTTH@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_770275_1 1005048.CFU_2388 5.15e-104 315.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,473GN@75682|Oxalobacteraceae 28216|Betaproteobacteria E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_560990_1 714943.Mucpa_6764 1.32e-53 191.0 COG1629@1|root,COG1629@2|Bacteria,4NH4T@976|Bacteroidetes,1IQJD@117747|Sphingobacteriia 976|Bacteroidetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_847312_1 1348657.M622_00490 5.35e-62 202.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,2KV1Y@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_847312_2 7159.AAEL015589-PA 4.93e-79 244.0 COG1960@1|root,KOG0139@2759|Eukaryota,38H6J@33154|Opisthokonta,3BC6X@33208|Metazoa,3CVK7@33213|Bilateria,41VCW@6656|Arthropoda 33208|Metazoa E flavin adenine dinucleotide binding. It is involved in the biological process described with oxidation-reduction process - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1130419_1 1201290.M902_1129 1.46e-60 208.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42NID@68525|delta/epsilon subdivisions,2MSNJ@213481|Bdellovibrionales,2WJ4P@28221|Deltaproteobacteria 213481|Bdellovibrionales M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_235345_1 29581.BW37_05191 5.47e-13 67.4 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,47395@75682|Oxalobacteraceae 28216|Betaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_235345_2 1500894.JQNN01000001_gene489 2.51e-36 129.0 COG4970@1|root,COG4970@2|Bacteria,1NGHS@1224|Proteobacteria,2WCQV@28216|Betaproteobacteria,474MH@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II transport protein GspH fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_884234_1 614083.AWQR01000031_gene2657 3.52e-132 397.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4AA18@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_98299_1 85643.Tmz1t_0766 9.39e-69 224.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,2KYF2@206389|Rhodocyclales 206389|Rhodocyclales C Aldehyde dehydrogenase family - - 1.2.1.39 ko:K00146 ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 - R02536 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_417247_1 1005395.CSV86_12725 1.51e-90 270.0 COG3806@1|root,COG3806@2|Bacteria,1R52I@1224|Proteobacteria,1RNI5@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG3806 Anti-sigma factor - - - - - - - - - - - - Cupin_7 k59_563094_1 497964.CfE428DRAFT_3393 5.28e-43 155.0 COG1073@1|root,COG1073@2|Bacteria,46TF5@74201|Verrucomicrobia 74201|Verrucomicrobia S alpha beta - - - - - - - - - - - - - k59_26119_1 1121920.AUAU01000021_gene2519 1.71e-122 360.0 COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria 57723|Acidobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_812495_1 221103.XP_007848121.1 4.11e-21 98.6 COG1112@1|root,KOG1804@2759|Eukaryota,38EBX@33154|Opisthokonta,3NVM7@4751|Fungi,3UZ1Y@5204|Basidiomycota,227VD@155619|Agaricomycetes,3W3IP@5338|Agaricales 4751|Fungi L helicase - - 3.6.4.13 ko:K18422 - - - - ko00000,ko01000,ko03019,ko03036 - - - AAA_11,AAA_12,zf-met k59_950182_1 358220.C380_10905 9.07e-115 355.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,4AA22@80864|Comamonadaceae 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_849606_1 420662.Mpe_A0383 4.73e-42 142.0 2EVDW@1|root,33NUA@2|Bacteria,1NMB8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_169515_1 865861.AZSU01000003_gene1911 7.38e-29 120.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,36DKN@31979|Clostridiaceae 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_389138_2 279714.FuraDRAFT_0249 5.07e-59 186.0 2F6NB@1|root,33Z4V@2|Bacteria,1NY7I@1224|Proteobacteria,2W3V6@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_593174_1 1122951.ATUE01000007_gene808 8.68e-105 306.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,3NINB@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iECH74115_1262.ECH74115_0566,iEKO11_1354.EKO11_3373,iG2583_1286.G2583_0586,iJN746.PP_1506 ADK,ADK_lid k59_317420_1 318161.Sden_1376 3.25e-71 234.0 COG0028@1|root,COG0028@2|Bacteria,1QUV8@1224|Proteobacteria,1T225@1236|Gammaproteobacteria,2QANI@267890|Shewanellaceae 1236|Gammaproteobacteria EH Belongs to the TPP enzyme family - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1130469_1 1230338.MOMA_05706 8.64e-44 156.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,3NJ8G@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_1098153_2 614083.AWQR01000009_gene724 5.26e-64 207.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,4AABF@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_703094_1 1144319.PMI16_03039 5.48e-166 487.0 COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,473Z7@75682|Oxalobacteraceae 28216|Betaproteobacteria I Poly(3-hydroxyalkanoate) synthetase - - - - - - - - - - - - DUF3141 k59_493286_1 1122197.ATWI01000009_gene1790 3.53e-103 318.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_98380_1 640081.Dsui_0674 4.07e-19 86.7 COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,2KWVJ@206389|Rhodocyclales 206389|Rhodocyclales D cell division protein ftsN - - - - - - - - - - - SPOR k59_98380_2 1485544.JQKP01000002_gene1491 1.85e-19 88.6 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,44V7S@713636|Nitrosomonadales 28216|Betaproteobacteria J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_98400_2 1396141.BATP01000042_gene1919 5.53e-14 70.9 COG2197@1|root,COG2197@2|Bacteria,46UBU@74201|Verrucomicrobia 74201|Verrucomicrobia T PFAM regulatory protein LuxR - - - - - - - - - - - - GerE,Response_reg k59_417345_2 29581.BW37_01072 5.18e-51 176.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VJQV@28216|Betaproteobacteria,475KN@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD - - - - - - - - - - - AMP-binding,AMP-binding_C k59_626180_1 78398.KS43_19665 9.72e-14 70.1 2CAZB@1|root,2Z9VC@2|Bacteria,1R89D@1224|Proteobacteria,1RPMA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - AAA_24 k59_812569_1 1122951.ATUE01000006_gene939 7.2e-101 305.0 COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1S02C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - DUF2048 k59_26214_1 1123070.KB899251_gene808 1.1e-39 143.0 COG0002@1|root,COG0002@2|Bacteria,46SA3@74201|Verrucomicrobia,2IU18@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Semialdehyde dehydrogenase, NAD binding domain argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_884454_1 261292.Nit79A3_2773 3.45e-37 129.0 COG2149@1|root,COG2149@2|Bacteria,1N173@1224|Proteobacteria,2VWEE@28216|Betaproteobacteria,373GN@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF202) - - - ko:K00389 - - - - ko00000 - - - DUF202 k59_1038666_1 322710.Avin_44290 9.03e-142 410.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria 1236|Gammaproteobacteria K acetyltransferase yghO GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - - k59_1038666_2 1266925.JHVX01000003_gene705 1.64e-13 67.8 COG0537@1|root,COG0537@2|Bacteria,1N49J@1224|Proteobacteria,2VWW7@28216|Betaproteobacteria,3737X@32003|Nitrosomonadales 28216|Betaproteobacteria FG Histidine triad (HIT) protein - - - - - - - - - - - - - k59_396284_1 945550.VISI1226_16638 6.28e-69 243.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria,1RQT4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Transglutaminase-like - - - - - - - - - - - - Transglut_core k59_432698_1 1514668.JOOA01000002_gene3068 4.96e-10 61.2 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WH8B@541000|Ruminococcaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_504236_1 1122951.ATUE01000005_gene1820 1.52e-46 155.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,3NJ26@468|Moraxellaceae 1236|Gammaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363 1.5.1.3 ko:K00287,ko:K18590 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 - - iECBD_1354.ECBD_3567,iECDH1ME8569_1439.ECDH1ME8569_0047,iECNA114_1301.ECNA114_0036,iEcDH1_1363.EcDH1_3551,iEcSMS35_1347.EcSMS35_0050,iG2583_1286.G2583_0050,iJN746.PP_5132,iNRG857_1313.NRG857_00250,iUMN146_1321.UM146_23020 DHFR_1 k59_608997_1 1209072.ALBT01000031_gene1791 1.98e-59 185.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1S617@1236|Gammaproteobacteria,1FHAT@10|Cellvibrio 1236|Gammaproteobacteria O FKBP-type peptidyl-prolyl cis-trans isomerase fbp - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,Rhodanese k59_608997_2 1441629.PCH70_35940 2.28e-18 77.4 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,1SC8W@1236|Gammaproteobacteria,1Z7WR@136849|Pseudomonas syringae group 1236|Gammaproteobacteria D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007049,GO:0007346,GO:0008150,GO:0009987,GO:0010564,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0032465,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051726,GO:0061640,GO:0065007,GO:0071840,GO:0071944,GO:0090529,GO:1901891,GO:1902410,GO:1902412,GO:1903047,GO:1903436 - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k59_396295_1 614083.AWQR01000005_gene1239 7.5e-124 365.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,4ABAF@80864|Comamonadaceae 28216|Betaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I algC GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_467302_1 1276756.AUEX01000013_gene1514 9.48e-115 339.0 COG3181@1|root,COG3181@2|Bacteria,1N561@1224|Proteobacteria,2VMBJ@28216|Betaproteobacteria,4AD3X@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM conserved - - - - - - - - - - - - TctC k59_823933_1 1000565.METUNv1_02030 3.87e-125 373.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUTR@206389|Rhodocyclales 206389|Rhodocyclales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_573734_1 745411.B3C1_17532 7.91e-28 114.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_930550_1 1000565.METUNv1_02894 9.48e-69 215.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,2KW12@206389|Rhodocyclales 206389|Rhodocyclales S Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_930550_2 1123367.C666_04885 1.4e-12 66.6 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,2KUVT@206389|Rhodocyclales 206389|Rhodocyclales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_823937_1 1454007.JAUG01000010_gene2520 1.35e-49 166.0 COG2220@1|root,COG2220@2|Bacteria,4NGD5@976|Bacteroidetes,1IRXP@117747|Sphingobacteriia 976|Bacteroidetes S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_966428_2 614083.AWQR01000005_gene969 9.39e-107 311.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,4AC2F@80864|Comamonadaceae 28216|Betaproteobacteria K RNA polymerase, sigma-24 subunit, ECF subfamily sigE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_39317_1 1198452.Jab_1c22370 7.8e-87 262.0 COG0457@1|root,COG0457@2|Bacteria,1R3PT@1224|Proteobacteria,2VN88@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1038689_1 488538.SAR116_0376 1.28e-58 201.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria,2U5NE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - - k59_1109260_1 1207063.P24_17877 1.79e-17 86.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2U0XK@28211|Alphaproteobacteria,2JQD6@204441|Rhodospirillales 204441|Rhodospirillales NT methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal k59_504251_1 1122951.ATUE01000005_gene1816 5.83e-154 456.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,3NIHN@468|Moraxellaceae 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_538110_1 1000565.METUNv1_02273 5.95e-09 52.8 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,2KX1P@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_538110_2 1231391.AMZF01000020_gene1916 1.5e-20 83.2 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,3T4QD@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_538110_3 1000565.METUNv1_02271 1.46e-90 265.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2VQ0A@28216|Betaproteobacteria,2KW4S@206389|Rhodocyclales 206389|Rhodocyclales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_538110_4 1000565.METUNv1_02270 4.14e-133 384.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,2KVIT@206389|Rhodocyclales 206389|Rhodocyclales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_467309_1 1000565.METUNv1_02534 6.73e-05 43.9 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,2KVRX@206389|Rhodocyclales 206389|Rhodocyclales C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_467309_2 1000565.METUNv1_02533 0.0 940.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,2KVB2@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_289214_1 882378.RBRH_02282 2.55e-19 81.3 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_573748_1 445972.ANACOL_01839 1.17e-75 241.0 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,248E9@186801|Clostridia,3WH9W@541000|Ruminococcaceae 186801|Clostridia S Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_2,Terminase_3,Terminase_3C k59_1002312_2 1000565.METUNv1_00881 5.47e-37 129.0 COG5652@1|root,COG5652@2|Bacteria,1NIUW@1224|Proteobacteria,2VXP4@28216|Betaproteobacteria 28216|Betaproteobacteria S VanZ like family - - - - - - - - - - - - VanZ k59_1002312_3 1000565.METUNv1_00882 2.57e-10 59.7 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VH0H@28216|Betaproteobacteria,2KW11@206389|Rhodocyclales 206389|Rhodocyclales M COG2148 Sugar transferases involved in lipopolysaccharide synthesis gumD - - ko:K03606 ko05111,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3 k59_1075461_1 748247.AZKH_2944 1.33e-96 299.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,2KVKE@206389|Rhodocyclales 206389|Rhodocyclales T PrkA family serine protein kinase prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_788921_1 1000565.METUNv1_00257 1.06e-180 517.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VKMW@28216|Betaproteobacteria,2KV2G@206389|Rhodocyclales 206389|Rhodocyclales I Poly-beta-hydroxybutyrate - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_647119_1 365044.Pnap_0800 3.86e-50 169.0 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,4ACT4@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_647119_2 365044.Pnap_0801 6.75e-44 152.0 COG0559@1|root,COG0559@2|Bacteria,1MXMC@1224|Proteobacteria,2VJ1Y@28216|Betaproteobacteria,4AASW@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_325732_1 190486.XAC3050 9.67e-24 108.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1X2YV@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_504265_1 1000565.METUNv1_03585 2.4e-148 417.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,2KV0X@206389|Rhodocyclales 206389|Rhodocyclales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1002315_1 1000565.METUNv1_02993 2.7e-48 157.0 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,2VVT5@28216|Betaproteobacteria,2KXDS@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_73963_1 1000565.METUNv1_01461 7.62e-32 117.0 COG2172@1|root,COG2172@2|Bacteria 2|Bacteria T sigma factor antagonist activity - - 2.7.11.1,3.1.3.3 ko:K04757,ko:K07315 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2,SpoIIE k59_73963_2 1000565.METUNv1_01462 2.43e-68 221.0 COG0664@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,2KX5A@206389|Rhodocyclales 206389|Rhodocyclales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_752374_1 459495.SPLC1_S260950 1.99e-05 50.4 COG2452@1|root,COG2452@2|Bacteria,1G4P1@1117|Cyanobacteria 1117|Cyanobacteria L ISSoc2, resolvase - - - - - - - - - - - - MerR,MerR_1,Resolvase k59_110049_1 97139.C824_04757 2.79e-33 129.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_859340_1 983917.RGE_04280 1.99e-60 207.0 COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,2VTMV@28216|Betaproteobacteria,1KNC3@119065|unclassified Burkholderiales 28216|Betaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_145651_1 1454004.AW11_03639 6.84e-112 350.0 COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,2VN4Y@28216|Betaproteobacteria 28216|Betaproteobacteria L RecF RecN SMC N terminal domain-containing protein - - - - - - - - - - - - AAA_23,AAA_27 k59_145651_2 1000565.METUNv1_01456 1.06e-107 317.0 COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria 28216|Betaproteobacteria S Haloacid dehalogenase, type II - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_73968_1 762903.Pedsa_2136 2.15e-45 150.0 COG0094@1|root,COG0094@2|Bacteria,4NEGY@976|Bacteroidetes,1IPX4@117747|Sphingobacteriia 976|Bacteroidetes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_73968_2 926559.JoomaDRAFT_2852 1.62e-42 140.0 COG0199@1|root,COG0199@2|Bacteria,4NQ6N@976|Bacteroidetes,1I2TX@117743|Flavobacteriia 976|Bacteroidetes J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_859341_1 1304883.KI912532_gene2521 2.27e-67 217.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,2KVFJ@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_859341_2 1454004.AW11_01180 1.45e-10 61.6 2BCK1@1|root,32662@2|Bacteria,1RHH4@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_966455_1 381666.PHG246 4.94e-94 291.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VJYJ@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator norR - - ko:K02584,ko:K12266 ko02020,ko05132,map02020,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_680882_1 1150600.ADIARSV_1529 1.38e-74 236.0 COG0010@1|root,COG0010@2|Bacteria,4NE5W@976|Bacteroidetes,1IQD9@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the arginase family - - 3.5.3.8 ko:K01479 ko00340,ko01100,map00340,map01100 M00045 R02285 RC00221,RC00681 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_325760_1 1038859.AXAU01000001_gene3082 6.28e-70 237.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JWEN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V MMPL family mdtC - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_538140_1 1000565.METUNv1_01895 6.95e-112 326.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,2VJPP@28216|Betaproteobacteria,2KVAN@206389|Rhodocyclales 206389|Rhodocyclales H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_1002343_1 640081.Dsui_2458 6.16e-29 110.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,2KUHJ@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1002343_2 1000565.METUNv1_00630 3.4e-172 495.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,2KVPJ@206389|Rhodocyclales 206389|Rhodocyclales J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_289258_2 1000565.METUNv1_00907 4.93e-52 173.0 COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VPIV@28216|Betaproteobacteria,2KWJN@206389|Rhodocyclales 206389|Rhodocyclales S ankyrin repeat - - - ko:K06867 - - - - ko00000 - - - Ank_2,Ank_3,Ank_4,Ank_5 k59_966463_1 1121033.AUCF01000006_gene4295 1.15e-106 332.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,2JQIV@204441|Rhodospirillales 204441|Rhodospirillales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_895931_1 69279.BG36_02090 7.46e-34 118.0 COG3609@1|root,COG3609@2|Bacteria,1N2U3@1224|Proteobacteria,2UC2F@28211|Alphaproteobacteria 28211|Alphaproteobacteria K addiction module - - - - - - - - - - - - - k59_895931_2 1437824.BN940_00986 8.41e-52 165.0 COG3668@1|root,COG3668@2|Bacteria,1RI5Y@1224|Proteobacteria,2VUW9@28216|Betaproteobacteria 28216|Betaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_432786_1 1157708.KB907464_gene473 5.84e-57 186.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VKYI@28216|Betaproteobacteria,4A9Y9@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_432786_2 614083.AWQR01000001_gene3117 1.11e-32 120.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJRS@28216|Betaproteobacteria,4AAWC@80864|Comamonadaceae 28216|Betaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1075502_4 1001240.GY21_18980 8.32e-34 141.0 COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria,4FPTW@85023|Microbacteriaceae 201174|Actinobacteria L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_467362_1 1195246.AGRI_10291 3.09e-29 111.0 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,465TQ@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the synthesis of activated sulfate cysC GO:0003674,GO:0003824,GO:0004020,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0042802,GO:0044237 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2750,iB21_1397.B21_02565,iBWG_1329.BWG_2486,iEC042_1314.EC042_2944,iEC55989_1330.EC55989_3023,iECBD_1354.ECBD_0974,iECB_1328.ECB_02600,iECDH10B_1368.ECDH10B_2918,iECDH1ME8569_1439.ECDH1ME8569_2660,iECD_1391.ECD_02600,iECH74115_1262.ECH74115_4002,iECIAI1_1343.ECIAI1_2852,iECO111_1330.ECO111_3474,iECO26_1355.ECO26_3819,iECSE_1348.ECSE_3002,iECSP_1301.ECSP_3698,iECUMN_1333.ECUMN_3074,iECW_1372.ECW_m2956,iECs_1301.ECs3604,iEKO11_1354.EKO11_1019,iEcDH1_1363.EcDH1_0938,iEcE24377_1341.EcE24377A_3051,iEcHS_1320.EcHS_A2888,iEcSMS35_1347.EcSMS35_2876,iG2583_1286.G2583_3398,iJO1366.b2750,iJR904.b2750,iSBO_1134.SBO_2770,iSDY_1059.SDY_2949,iSFV_1184.SFV_2748,iSSON_1240.SSON_2898,iUMNK88_1353.UMNK88_3426,iWFL_1372.ECW_m2956,iY75_1357.Y75_RS14315,iZ_1308.Z4058 APS_kinase k59_467362_2 1382303.JPOM01000001_gene1451 5.67e-18 82.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2TT5T@28211|Alphaproteobacteria,2KF7Y@204458|Caulobacterales 204458|Caulobacterales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1109309_1 397945.Aave_2383 8.33e-50 180.0 COG0454@1|root,COG0503@1|root,COG0827@1|root,COG0456@2|Bacteria,COG0503@2|Bacteria,COG0827@2|Bacteria,1PE9Y@1224|Proteobacteria,2VP0T@28216|Betaproteobacteria,4AGXR@80864|Comamonadaceae 28216|Betaproteobacteria K Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis - - - - - - - - - - - - - k59_290339_1 1000565.METUNv1_01609 1.9e-150 424.0 COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2VVGP@28216|Betaproteobacteria,2KX6M@206389|Rhodocyclales 206389|Rhodocyclales K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_290339_2 1000565.METUNv1_01610 0.0 883.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,2KUJ5@206389|Rhodocyclales 28216|Betaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtA - - ko:K02051,ko:K15576 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - NMT1_2 k59_290339_3 316055.RPE_4637 1.43e-67 213.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria,3JQVS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P nitrate ABC transporter nrtB - - ko:K02050,ko:K15577 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - BPD_transp_1 k59_254427_1 398578.Daci_0655 1.28e-81 262.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,4A9N1@80864|Comamonadaceae 28216|Betaproteobacteria NT Signal transducing histidine kinase, homodimeric cheA GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_538943_1 1000565.METUNv1_03756 4.31e-80 251.0 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2VJT7@28216|Betaproteobacteria,2KUCI@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyl transferases group 1 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_transf_4 k59_967142_1 42099.EPrPV00000024139 1.96e-42 157.0 2990X@1|root,2RG2A@2759|Eukaryota,1MK3J@121069|Pythiales 42099.EPrPV00000024139|- - - - - - - - - - - - - - - - k59_789867_1 1187851.A33M_4336 4.09e-54 174.0 COG0633@1|root,COG0633@2|Bacteria,1N22M@1224|Proteobacteria,2UC5J@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2,Rubrerythrin k59_789867_2 1116472.MGMO_11c00110 9.82e-42 139.0 COG2146@1|root,COG2146@2|Bacteria,1RHEY@1224|Proteobacteria,1SA8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Rieske-like [2Fe-2S] domain - - - ko:K15762 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002 - - - Rieske k59_184327_1 1380391.JIAS01000019_gene1248 8.81e-51 171.0 COG2520@1|root,COG2520@2|Bacteria,1N43N@1224|Proteobacteria,2UDB4@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Methyltransferase fkbm family - - - - - - - - - - - - - k59_327198_1 760117.JN27_06755 1.36e-76 244.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,47323@75682|Oxalobacteraceae 28216|Betaproteobacteria S Cobalamin synthesis protein yjiA_1 - - - - - - - - - - - CobW_C,cobW k59_434328_1 397945.Aave_4341 1.33e-80 269.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,4AAZM@80864|Comamonadaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_825034_1 1000565.METUNv1_00811 1.7e-49 159.0 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2VUTK@28216|Betaproteobacteria,2KWW4@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_897003_1 887062.HGR_11640 7.87e-99 298.0 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,2VIDF@28216|Betaproteobacteria,4AAI3@80864|Comamonadaceae 28216|Betaproteobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_290360_1 1000565.METUNv1_00993 0.000107 50.4 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_723978_2 1288494.EBAPG3_25770 1.13e-23 94.0 COG2965@1|root,COG2965@2|Bacteria,1QAGQ@1224|Proteobacteria,2WAH5@28216|Betaproteobacteria,373M9@32003|Nitrosomonadales 28216|Betaproteobacteria L Binds single-stranded DNA at the primosome assembly site (PAS) priB - - ko:K02686 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SSB k59_723985_1 640081.Dsui_1114 5.55e-28 111.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,2KUZ8@206389|Rhodocyclales 206389|Rhodocyclales H Coenzyme F390 synthetase - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_723985_2 582744.Msip34_2108 1.66e-20 86.7 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VS2C@28216|Betaproteobacteria,2KMUY@206350|Nitrosomonadales 206350|Nitrosomonadales L Peptidase S24-like - - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - Peptidase_S24 k59_82039_1 1041142.ATTP01000010_gene1486 1.1e-45 162.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2TU3M@28211|Alphaproteobacteria,4BBEB@82115|Rhizobiaceae 28211|Alphaproteobacteria GM ATP-binding protein wzt - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_723986_1 1198452.Jab_1c06330 1.73e-139 396.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,47359@75682|Oxalobacteraceae 28216|Betaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_445540_1 1000565.METUNv1_02606 4.24e-149 430.0 COG0840@1|root,COG0840@2|Bacteria,1RBQH@1224|Proteobacteria,2VNG3@28216|Betaproteobacteria,2KVTI@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_1115195_1 1121033.AUCF01000001_gene1946 5.38e-64 206.0 COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,2JQ5B@204441|Rhodospirillales 204441|Rhodospirillales E COG0626 Cystathionine beta-lyases cystathionine gamma-synthases metC - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1115195_2 1238190.AMQY01000014_gene1024 1.56e-10 59.3 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XJUI@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_46727_3 1401065.HMPREF2130_07665 2.05e-18 77.8 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,3T4QD@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_46727_4 640081.Dsui_0350 6.33e-32 112.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,2KX1P@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_613921_1 1157708.KB907458_gene1821 1.6e-30 115.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,4AA7K@80864|Comamonadaceae 28216|Betaproteobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_613921_2 399795.CtesDRAFT_PD4298 1.91e-50 160.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2VSCX@28216|Betaproteobacteria,4AEI1@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_687144_1 29581.BW37_01521 5.98e-65 218.0 COG3591@1|root,COG3591@2|Bacteria,1MYRM@1224|Proteobacteria,2WFYI@28216|Betaproteobacteria,4790B@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 k59_82045_1 1198452.Jab_1c01080 4.32e-70 216.0 COG0745@1|root,COG0745@2|Bacteria,1MZQA@1224|Proteobacteria,2WBEJ@28216|Betaproteobacteria,475NH@75682|Oxalobacteraceae 28216|Betaproteobacteria KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_221819_1 29581.BW37_01826 7.16e-107 337.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,47372@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_299403_1 397945.Aave_1278 5.69e-12 62.8 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2VSCN@28216|Betaproteobacteria,4AECI@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1178) - - - - - - - - - - - - DUF1178 k59_299403_2 1248916.ANFY01000013_gene1923 8.24e-49 172.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales 204457|Sphingomonadales V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_833734_1 338969.Rfer_2056 3.9e-61 197.0 COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2VI9B@28216|Betaproteobacteria,4AC5C@80864|Comamonadaceae 28216|Betaproteobacteria S Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_299412_1 237609.PSAKL28_39860 1.62e-70 230.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1RMNG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane-associated metal-dependent hydrolase eptA - 2.7.8.43 ko:K03760,ko:K19353 ko00540,ko01503,map00540,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_154719_1 1000565.METUNv1_01946 1.58e-139 403.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,2KVNM@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the dGTPase family. Type 2 subfamily dgt1 - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_404577_1 1166948.JPZL01000003_gene534 1.54e-12 68.9 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1S3NG@1236|Gammaproteobacteria,1XJRX@135619|Oceanospirillales 135619|Oceanospirillales S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_759595_2 296591.Bpro_4686 2.06e-50 164.0 COG1846@1|root,COG1846@2|Bacteria,1NJH3@1224|Proteobacteria,2VPZN@28216|Betaproteobacteria,4ADKD@80864|Comamonadaceae 28216|Betaproteobacteria K Regulatory protein MarR - - - - - - - - - - - - HTH_27,MarR_2 k59_1088801_2 984262.SGRA_2200 1.89e-30 119.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1IQ87@117747|Sphingobacteriia 976|Bacteroidetes V COG1131 ABC-type multidrug transport system ATPase component gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_83413_1 1000565.METUNv1_01865 7.09e-136 386.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,2KWRB@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_476460_2 411464.DESPIG_01126 7.22e-05 45.4 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,42P0H@68525|delta/epsilon subdivisions,2WPNP@28221|Deltaproteobacteria,2M9PG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_833765_1 614083.AWQR01000020_gene186 3.67e-17 76.3 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,4AEDM@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Rhodanese domain protein glpE - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_833765_2 614083.AWQR01000020_gene187 1.05e-70 218.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,4AAD1@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_197551_1 760192.Halhy_0767 5.92e-33 129.0 COG0732@1|root,COG0732@2|Bacteria,4NP66@976|Bacteroidetes,1IUHY@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Restriction endonuclease, type I, S subunit, EcoBI - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_448015_1 397945.Aave_1016 2.91e-68 215.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,4ADJ3@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_1046613_1 614083.AWQR01000014_gene2461 3.16e-94 282.0 COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2VH48@28216|Betaproteobacteria,4ABSG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1046613_2 398578.Daci_2393 7.98e-15 73.6 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,4A9JW@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_476511_1 1288494.EBAPG3_12700 6.45e-31 112.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,37321@32003|Nitrosomonadales 28216|Betaproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_476511_2 987059.RBXJA2T_09387 3.8e-15 73.2 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria 28216|Betaproteobacteria I Cyclase dehydrase - - - - - - - - - - - - Polyketide_cyc k59_1046618_1 1157708.KB907460_gene1434 1.67e-89 286.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJTX@28216|Betaproteobacteria,4ACYQ@80864|Comamonadaceae 28216|Betaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,dCache_1 k59_833805_1 118797.XP_007456400.1 2.9e-91 275.0 COG0492@1|root,KOG0404@2759|Eukaryota,38I0K@33154|Opisthokonta,3BUZA@33208|Metazoa,3DER1@33213|Bilateria 33208|Metazoa O Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_370698_1 287.DR97_2953 2.77e-73 241.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1YEV8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_759667_1 1000565.METUNv1_00698 5.97e-207 598.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps - - 1.8.1.8 ko:K04084,ko:K08344 - - - - ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.5 - - DsbC,DsbD,Thioredoxin_7 k59_868317_2 565033.GACE_0846 0.000232 47.0 2DZ6C@1|root,2N57C@2157|Archaea,2Y3ZI@28890|Euryarchaeota,2478H@183980|Archaeoglobi 183980|Archaeoglobi S Phage virion morphogenesis family - - - - - - - - - - - - Phage_tail_S k59_868317_4 1070319.CAGGBEG34_330029 1.4e-24 95.9 2C2XK@1|root,32ZQV@2|Bacteria,1N85V@1224|Proteobacteria,2VW0J@28216|Betaproteobacteria,1KAIF@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_197633_1 243159.AFE_1475 1.54e-22 92.4 COG2361@1|root,COG2361@2|Bacteria,1NDJN@1224|Proteobacteria,1SUBE@1236|Gammaproteobacteria,2NDV3@225057|Acidithiobacillales 225057|Acidithiobacillales S Protein of unknown function DUF86 - - - - - - - - - - - - - k59_197633_2 640081.Dsui_1148 5.34e-65 202.0 COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,2VR6M@28216|Betaproteobacteria,2KWDQ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_476531_2 301.JNHE01000002_gene2094 1.42e-28 115.0 28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1YF5T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Fatty acid cis/trans isomerase (CTI) cti - - - - - - - - - - - CTI k59_725635_1 1000565.METUNv1_00825 7.57e-65 207.0 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2VJHA@28216|Betaproteobacteria,2KWAS@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_404650_1 1000565.METUNv1_02739 1.63e-113 329.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,2VISP@28216|Betaproteobacteria,2KV43@206389|Rhodocyclales 206389|Rhodocyclales L 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_262839_1 312153.Pnuc_1663 5.65e-93 283.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHD2@28216|Betaproteobacteria,1K0HV@119060|Burkholderiaceae 28216|Betaproteobacteria EGP TIGRFAM metabolite H symporter, major facilitator superfamily (MFS) citA - - ko:K03288 - - - - ko00000,ko02000 2.A.1.6.1,2.A.1.6.7 - - MFS_1,Sugar_tr k59_662470_1 886293.Sinac_7353 2.49e-32 121.0 COG3361@1|root,COG3361@2|Bacteria,2IZQT@203682|Planctomycetes 203682|Planctomycetes S Uncharacterized conserved protein (COG2071) - - - ko:K09166 - - - - ko00000 - - - DUF2071 k59_688652_1 29581.BW37_03306 3.71e-86 277.0 COG4772@1|root,COG4772@2|Bacteria,1MXJU@1224|Proteobacteria,2VN9X@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_370750_2 1538295.JY96_19530 4.8e-38 144.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KKGK@119065|unclassified Burkholderiales 28216|Betaproteobacteria NT Four helix bundle sensory module for signal transduction - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_118586_2 1000565.METUNv1_01657 4.23e-64 209.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VHFE@28216|Betaproteobacteria,2KVID@206389|Rhodocyclales 206389|Rhodocyclales P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC k59_154867_1 1349767.GJA_3783 6.45e-22 95.1 COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,2VKWI@28216|Betaproteobacteria,472UN@75682|Oxalobacteraceae 28216|Betaproteobacteria T Cache_2 degS - 2.7.13.3 ko:K02480 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,sCache_2 k59_11903_1 688245.CtCNB1_1081 9.08e-158 447.0 COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VJN5@28216|Betaproteobacteria,4AACW@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_11903_2 391735.Veis_4074 7.52e-10 58.5 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VJA0@28216|Betaproteobacteria,4ABV2@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_725680_1 358220.C380_23715 8.35e-168 476.0 COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,4AAZP@80864|Comamonadaceae 1224|Proteobacteria E amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1046735_1 1122951.ATUE01000008_gene66 3.91e-71 224.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,3NKBI@468|Moraxellaceae 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_725682_1 1223410.KN050846_gene1794 7.71e-30 118.0 COG0470@1|root,COG0470@2|Bacteria,4NEYF@976|Bacteroidetes,1HXGT@117743|Flavobacteriia 976|Bacteroidetes L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_938196_1 667632.KB890173_gene3864 1.59e-75 235.0 COG3619@1|root,COG3619@2|Bacteria,1NNMJ@1224|Proteobacteria,2VIM6@28216|Betaproteobacteria,1K2V4@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1275) - - - - - - - - - - - - DUF1232,DUF1275 k59_938196_2 1123487.KB892866_gene1752 1.73e-06 51.2 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VI49@28216|Betaproteobacteria,2KV1T@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_938201_1 640081.Dsui_0896 2.56e-113 354.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY9@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_759732_1 1000565.METUNv1_00041 3.96e-132 396.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,2KUWP@206389|Rhodocyclales 206389|Rhodocyclales O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_3 k59_476593_1 1195246.AGRI_15045 9.52e-52 189.0 COG2202@1|root,COG2203@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1RX68@1236|Gammaproteobacteria,46688@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2203 FOG GAF domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3 k59_197744_1 1000565.METUNv1_03878 3.17e-50 164.0 COG0695@1|root,COG0695@2|Bacteria,1N7X3@1224|Proteobacteria,2VVPB@28216|Betaproteobacteria,2KWYJ@206389|Rhodocyclales 206389|Rhodocyclales O Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124,Glutaredoxin k59_197744_2 1000565.METUNv1_03879 5.47e-42 151.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,2KV0N@206389|Rhodocyclales 206389|Rhodocyclales E Oligopeptidase prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_223254_1 93220.LV28_12460 1.08e-40 139.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,1K6XV@119060|Burkholderiaceae 28216|Betaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_519054_1 614083.AWQR01000030_gene2794 2.45e-130 375.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,4AAKR@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_580903_1 1000565.METUNv1_00572 8.69e-54 169.0 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,2KXB3@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_580903_2 1000565.METUNv1_00573 6.17e-32 115.0 COG0791@1|root,COG0791@2|Bacteria,1RJ3U@1224|Proteobacteria,2VSD3@28216|Betaproteobacteria,2KWTG@206389|Rhodocyclales 206389|Rhodocyclales M NLP P60 protein - - - - - - - - - - - - NLPC_P60 k59_725729_2 1201290.M902_2650 1.75e-118 343.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2MSX1@213481|Bdellovibrionales,2WJMN@28221|Deltaproteobacteria 213481|Bdellovibrionales J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24,SEC-C k59_66596_2 3988.XP_002534847.1 2.33e-29 115.0 KOG1199@1|root,KOG1199@2759|Eukaryota 2759|Eukaryota S 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity - - 1.1.1.178,1.1.1.35 ko:K08683 ko00280,ko01100,ko01110,ko01130,ko05010,map00280,map01100,map01110,map01130,map05010 - R04203 RC00525 ko00000,ko00001,ko01000,ko03029,ko04147 - - - adh_short k59_1101145_1 640081.Dsui_0723 1.6e-120 370.0 COG0835@1|root,COG0835@2|Bacteria,1QVCF@1224|Proteobacteria,2VK5W@28216|Betaproteobacteria,2KVUN@206389|Rhodocyclales 206389|Rhodocyclales NT Two component signalling adaptor domain - - - - - - - - - - - - CheW k59_816320_1 391596.PBAL39_18164 0.000915 47.8 COG4206@1|root,COG4206@2|Bacteria,4PKKN@976|Bacteroidetes,1J0HV@117747|Sphingobacteriia 976|Bacteroidetes H COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_629096_1 1122951.ATUE01000005_gene2236 3.35e-51 175.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,3NJ8X@468|Moraxellaceae 1236|Gammaproteobacteria J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_498874_1 1450525.JATV01000023_gene2333 5.61e-50 166.0 COG1538@1|root,COG1538@2|Bacteria,4NVE6@976|Bacteroidetes,1I9S7@117743|Flavobacteriia,2NYJX@237|Flavobacterium 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_498887_2 1166016.W5S_0297 3.12e-17 82.4 COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1MRF6@122277|Pectobacterium 1236|Gammaproteobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm lptA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065 OstA k59_498887_3 1122951.ATUE01000008_gene3 1.65e-25 100.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,3NIKP@468|Moraxellaceae 1236|Gammaproteobacteria S ABC transporter lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_890261_1 338969.Rfer_3760 1.03e-77 256.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,4ACE6@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_421445_1 748658.KB907312_gene1638 1.56e-21 95.5 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,1RRFQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Arsenical pump-driving ATPase arsA - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase,CbiA k59_498898_1 694427.Palpr_2923 1.84e-45 158.0 COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia,22WRZ@171551|Porphyromonadaceae 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 yghO - - - - - - - - - - - Acetyltransf_1 k59_816351_1 582744.Msip34_0201 6.34e-40 135.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,2KMX3@206350|Nitrosomonadales 206350|Nitrosomonadales J PFAM sigma 54 modulation protein ribosomal protein S30EA - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_567511_1 1144319.PMI16_01208 7.66e-109 339.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,472IP@75682|Oxalobacteraceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1135031_1 1000565.METUNv1_00428 4.07e-22 100.0 COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria,2VN25@28216|Betaproteobacteria,2KXUF@206389|Rhodocyclales 206389|Rhodocyclales P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp,cNMP_binding k59_30322_1 1157708.KB907452_gene3946 6.01e-71 226.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,4A9SE@80864|Comamonadaceae 28216|Betaproteobacteria U General secretion pathway protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_816366_1 1122951.ATUE01000006_gene1322 1.65e-105 313.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,3NIZR@468|Moraxellaceae 1236|Gammaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934 DAHP_synth_1 k59_775993_1 349965.yinte0001_19760 3.04e-23 95.1 COG0248@1|root,COG0248@2|Bacteria,1N1E9@1224|Proteobacteria,1S9NH@1236|Gammaproteobacteria,41FXE@629|Yersinia 1236|Gammaproteobacteria FP Ppx GppA phosphatase - - - - - - - - - - - - - k59_775993_2 543913.D521_0304 3.49e-13 65.5 2E69Z@1|root,330XW@2|Bacteria,1MZGG@1224|Proteobacteria,2VUXC@28216|Betaproteobacteria 28216|Betaproteobacteria C Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - - - - - - - - - - HIPIP k59_744365_1 1000565.METUNv1_03015 5.57e-107 328.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,2KUF0@206389|Rhodocyclales 206389|Rhodocyclales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_744373_1 194699.Q775D1_BPBPP 2.96e-167 489.0 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1135078_1 3988.XP_002538282.1 7.8e-13 67.4 COG0730@1|root,2SJ1U@2759|Eukaryota 2759|Eukaryota S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_1135078_2 1000565.METUNv1_03258 5.25e-66 212.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,2KVKC@206389|Rhodocyclales 206389|Rhodocyclales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_239444_1 572480.Arnit_0719 3.69e-05 46.2 COG4303@1|root,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,42NG5@68525|delta/epsilon subdivisions 1224|Proteobacteria E PFAM Ethanolamine ammonia lyase large subunit eutB - 4.3.1.7 ko:K03735 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutB k59_239444_2 1198452.Jab_2c33400 2.45e-38 137.0 COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,2VJ8Y@28216|Betaproteobacteria,473X3@75682|Oxalobacteraceae 28216|Betaproteobacteria E Belongs to the EutC family eutC - 4.3.1.7 ko:K03736 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutC k59_421509_1 1397527.Q670_13710 5.1e-42 145.0 COG1418@1|root,COG1418@2|Bacteria,1RJ5U@1224|Proteobacteria,1SAZE@1236|Gammaproteobacteria,1XPKV@135619|Oceanospirillales 135619|Oceanospirillales S mRNA catabolic process - - - - - - - - - - - - - k59_421509_2 697282.Mettu_2974 2.9e-34 129.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,1RNIM@1236|Gammaproteobacteria,1XFAA@135618|Methylococcales 135618|Methylococcales EGP Sugar (and other) transporter - - - ko:K03762 - - - - ko00000,ko02000 2.A.1.6.4 - - Sugar_tr k59_499001_1 1267211.KI669560_gene1916 7.67e-68 231.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1IPAN@117747|Sphingobacteriia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_776039_1 871585.BDGL_001729 2.69e-10 60.5 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RN38@1236|Gammaproteobacteria,3NT93@468|Moraxellaceae 1236|Gammaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_776039_2 1395571.TMS3_0114755 1.06e-23 94.0 COG3278@1|root,COG3278@2|Bacteria,1N9ZN@1224|Proteobacteria 1224|Proteobacteria O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_499026_1 631362.Thi970DRAFT_04056 4.15e-14 70.5 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1S9EB@1236|Gammaproteobacteria,1X2R5@135613|Chromatiales 135613|Chromatiales S Sensors of blue-light using FAD - - - - - - - - - - - - BLUF k59_499026_2 398578.Daci_4545 4.57e-11 62.4 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIA6@28216|Betaproteobacteria,4A9U6@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_137655_1 1123277.KB893205_gene6323 3.39e-42 156.0 COG3291@1|root,COG3291@2|Bacteria,4PKTY@976|Bacteroidetes,47RAA@768503|Cytophagia 976|Bacteroidetes M ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS,fn3 k59_103324_1 76114.ebA1348 2.36e-96 292.0 COG4643@1|root,COG4643@2|Bacteria,1MVGY@1224|Proteobacteria,2WEGR@28216|Betaproteobacteria,2KYSU@206389|Rhodocyclales 206389|Rhodocyclales S Toprim domain - - - - - - - - - - - - - k59_921857_1 614083.AWQR01000009_gene731 1.41e-59 204.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4ACRA@80864|Comamonadaceae 28216|Betaproteobacteria NU General secretory system II, protein E domain protein - - - ko:K02454,ko:K02652,ko:K12276 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - GAF,T2SSE,T2SSE_N k59_921857_2 614083.AWQR01000009_gene732 3.33e-26 102.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,4AA3Q@80864|Comamonadaceae 28216|Betaproteobacteria S cAMP phosphodiesterases class-II - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_30419_1 1000565.METUNv1_01825 2.23e-167 474.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VK57@28216|Betaproteobacteria,2KV84@206389|Rhodocyclales 206389|Rhodocyclales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroA - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_816483_1 640081.Dsui_0706 7.41e-53 172.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,2VTYZ@28216|Betaproteobacteria,2KXFY@206389|Rhodocyclales 206389|Rhodocyclales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_992555_1 1144319.PMI16_03357 0.000122 43.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJE4@28216|Betaproteobacteria,476ZR@75682|Oxalobacteraceae 28216|Betaproteobacteria NT Cache domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_1138333_1 1000565.METUNv1_03764 1.38e-91 281.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,2KVCF@206389|Rhodocyclales 206389|Rhodocyclales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_33223_1 338969.Rfer_1708 2.81e-85 268.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,4A9QR@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_33223_2 1008459.TASI_1264 5.68e-05 44.7 COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2VIIF@28216|Betaproteobacteria,3T1NE@506|Alcaligenaceae 28216|Betaproteobacteria E Thiamine biosynthesis protein thio thiO - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_710055_1 504832.OCAR_6064 3.94e-76 253.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JSVA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K07788,ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_140600_1 29581.BW37_01712 1.1e-68 219.0 COG3781@1|root,COG3781@2|Bacteria,1MX91@1224|Proteobacteria,2VHY9@28216|Betaproteobacteria,476XM@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bestrophin, RFP-TM, chloride channel - - - ko:K08994 - - - - ko00000,ko02000 1.A.46.2 - - Bestrophin k59_106473_1 546274.EIKCOROL_01906 5.66e-16 76.3 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,2KPIX@206351|Neisseriales 206351|Neisseriales S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF1732,YicC_N k59_106473_2 1122951.ATUE01000005_gene1968 6.2e-93 277.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,3NKHV@468|Moraxellaceae 1236|Gammaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin k59_33241_2 373994.Riv7116_4183 3.23e-22 99.0 COG0438@1|root,COG0438@2|Bacteria,1G3D4@1117|Cyanobacteria,1HQXS@1161|Nostocales 1117|Cyanobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_1138376_2 1000565.METUNv1_00058 5.45e-60 202.0 COG3614@1|root,COG5001@1|root,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2WI5T@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_285226_1 1221522.B723_11075 1.86e-115 349.0 COG4930@1|root,COG4930@2|Bacteria,1MWGE@1224|Proteobacteria,1RQKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent Lon-type protease - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - Lon_2,Lon_C,MIT_C k59_1103635_2 1265502.KB905931_gene1714 1.59e-27 101.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,4ADXX@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the HesB IscA family iscA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1138383_1 1304883.KI912532_gene181 2.78e-22 95.9 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KVAE@206389|Rhodocyclales 206389|Rhodocyclales NT Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_1138383_2 1000565.METUNv1_02609 1.18e-11 62.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,2VR41@28216|Betaproteobacteria,2KW81@206389|Rhodocyclales 206389|Rhodocyclales NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_33268_1 115417.EPrPW00000017426 3.18e-20 93.2 COG0164@1|root,KOG2299@2759|Eukaryota,1MFFZ@121069|Pythiales 121069|Pythiales L Ribonuclease. Source PGD - - - - - - - - - - - - RNase_HII k59_33270_1 358220.C380_13350 3.19e-115 335.0 COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2VH22@28216|Betaproteobacteria,4AAMM@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family gno1 - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short,adh_short_C2 k59_570480_2 1250005.PHEL85_2799 1.71e-68 214.0 28I0D@1|root,2Z857@2|Bacteria,4NFD6@976|Bacteroidetes,1HZJ3@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF1826 k59_140665_1 338969.Rfer_3358 1.26e-26 105.0 COG1075@1|root,COG1075@2|Bacteria,1NB6J@1224|Proteobacteria,2VJTN@28216|Betaproteobacteria,4ABWK@80864|Comamonadaceae 28216|Betaproteobacteria S Alpha beta hydrolase fold lip - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_106515_1 1198452.Jab_1c19300 3.96e-45 156.0 COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,2VGZN@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase group 1 - - - ko:K03208 - - - - ko00000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1 k59_106515_2 1424334.W822_10725 1.09e-39 141.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,3T20C@506|Alcaligenaceae 28216|Betaproteobacteria M UDP-glucose 4-epimerase galE - 5.1.3.2,5.1.3.5 ko:K01784,ko:K12448 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R01473,R02984 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_748010_1 1000565.METUNv1_03998 8.57e-117 348.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VJS8@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_285282_1 765914.ThisiDRAFT_0229 1.04e-62 196.0 COG1848@1|root,COG1848@2|Bacteria,1N3CQ@1224|Proteobacteria,1S919@1236|Gammaproteobacteria,1WYY3@135613|Chromatiales 135613|Chromatiales S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_285282_2 1415779.JOMH01000001_gene966 3.74e-12 66.2 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1X60V@135614|Xanthomonadales 135614|Xanthomonadales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1103709_1 1198452.Jab_1c15290 2.23e-57 181.0 COG4564@1|root,COG4564@2|Bacteria,1RFW5@1224|Proteobacteria,2VTWN@28216|Betaproteobacteria 28216|Betaproteobacteria T Cache domain - - - - - - - - - - - - sCache_2 k59_924576_1 614083.AWQR01000046_gene3330 1.64e-68 219.0 2E8RT@1|root,3332S@2|Bacteria,1NCEC@1224|Proteobacteria,2VXCV@28216|Betaproteobacteria,4AFE3@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_819279_1 1076550.LH22_15905 2.91e-08 56.2 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,3VY5I@53335|Pantoea 1236|Gammaproteobacteria M RND efflux system, outer membrane lipoprotein, NodT family nodT - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_178023_1 1209072.ALBT01000026_gene3683 1.86e-32 118.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1FG5J@10|Cellvibrio 1236|Gammaproteobacteria O C-terminal domain of 1-Cys peroxiredoxin ahpC GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_178023_2 1205680.CAKO01000040_gene634 3.46e-26 107.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2TZ9G@28211|Alphaproteobacteria,2JQFS@204441|Rhodospirillales 204441|Rhodospirillales O Thioredoxin domain ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_242676_2 1173020.Cha6605_3189 9.65e-69 215.0 COG0863@1|root,COG0863@2|Bacteria,1G58I@1117|Cyanobacteria 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - - k59_1138505_1 663610.JQKO01000003_gene1516 8.86e-52 168.0 COG0607@1|root,COG0607@2|Bacteria,1RKR9@1224|Proteobacteria,2UBEK@28211|Alphaproteobacteria,3NBJP@45404|Beijerinckiaceae 28211|Alphaproteobacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_1138505_2 365044.Pnap_0569 1.19e-52 170.0 COG3909@1|root,COG3909@2|Bacteria 2|Bacteria C cytochrome - - - - - - - - - - - - Cytochrom_C_2 k59_178072_1 159087.Daro_2048 9.19e-30 122.0 COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVRJ@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,Response_reg k59_631420_1 1000565.METUNv1_03780 4.6e-146 446.0 COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria,2WEH7@28216|Betaproteobacteria,2KY9X@206389|Rhodocyclales 206389|Rhodocyclales S Heparinase II/III-like protein - - - - - - - - - - - - DUF4962,Hepar_II_III,VanZ k59_1138528_2 349521.HCH_04621 2.66e-52 174.0 COG2199@1|root,COG3706@2|Bacteria,1R76U@1224|Proteobacteria,1S15R@1236|Gammaproteobacteria,1XJR4@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg k59_748125_1 1198452.Jab_1c21260 1.08e-31 121.0 COG1819@1|root,COG1819@2|Bacteria,1MW1K@1224|Proteobacteria,2VMKC@28216|Betaproteobacteria 28216|Betaproteobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - - - - - - - - - - - - Glyco_tran_28_C,UDPGT k59_1138543_1 358681.BBR47_12990 4.86e-40 144.0 2DH1B@1|root,2ZY22@2|Bacteria,1VQZM@1239|Firmicutes,4HUMA@91061|Bacilli,272BA@186822|Paenibacillaceae 91061|Bacilli S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_570603_1 1341695.BBOMB_0731 1.66e-38 147.0 COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4CYTB@85004|Bifidobacteriales 201174|Actinobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_995633_1 365046.Rta_28750 1.77e-12 66.2 COG3279@1|root,COG3279@2|Bacteria,1MVJI@1224|Proteobacteria,2VPZX@28216|Betaproteobacteria,4AA5R@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM response regulator receiver algR - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_995633_2 1123255.JHYS01000001_gene1874 4.63e-51 173.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,4AA12@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase internal region algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_956798_1 29581.BW37_03339 1.55e-38 133.0 COG3122@1|root,COG3122@2|Bacteria,1N15V@1224|Proteobacteria,2VQQI@28216|Betaproteobacteria,4745K@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2058) yaiL - - ko:K09912 - - - - ko00000 - - - DUF2058 k59_956798_2 522306.CAP2UW1_1982 1.7e-08 53.9 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,2VW2I@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_69822_1 887062.HGR_03002 5.39e-74 229.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,4ABS5@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_779422_1 1244869.H261_12381 4.46e-36 132.0 COG0407@1|root,COG0407@2|Bacteria,1R9IN@1224|Proteobacteria 1224|Proteobacteria H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_33458_1 666681.M301_1811 3.2e-129 376.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria 28216|Betaproteobacteria Q dienelactone hydrolase clcD - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1077616_1 1122951.ATUE01000005_gene2112 1.31e-49 165.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,3NK2Z@468|Moraxellaceae 1236|Gammaproteobacteria E Methylenetetrahydrofolate reductase metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0117,iSBO_1134.SBO_3961 MTHFR k59_1077616_2 1323663.AROI01000013_gene261 4.03e-124 366.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_539265_1 1198452.Jab_1c10810 1.98e-119 355.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,4724A@75682|Oxalobacteraceae 28216|Betaproteobacteria U Ammonium Transporter Family amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_362671_1 1000565.METUNv1_01903 5.53e-133 395.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_291653_2 1509403.GW12_25980 4.56e-86 269.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,3NII1@468|Moraxellaceae 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yjjK GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_436205_1 983917.RGE_46730 6.32e-52 171.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,1KJAC@119065|unclassified Burkholderiales 28216|Betaproteobacteria L exodeoxyribonuclease III exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_753887_1 243924.LT42_22445 1.34e-45 168.0 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,1RPPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase group 1 wbdA1 - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_932176_1 153721.MYP_623 9.08e-35 132.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,47JB5@768503|Cytophagia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1040917_1 1000565.METUNv1_00382 3.52e-95 289.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,2KUMC@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1040917_2 1000565.METUNv1_00381 1.2e-152 433.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,2KV7R@206389|Rhodocyclales 206389|Rhodocyclales H dihydropteroate synthase dhpS - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_968061_1 159087.Daro_0457 5.73e-95 297.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales 206389|Rhodocyclales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_753892_1 1000565.METUNv1_02423 6.8e-19 84.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,2KVD2@206389|Rhodocyclales 206389|Rhodocyclales V ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_753892_2 381666.H16_A3422 1.41e-08 56.2 COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,2VXUB@28216|Betaproteobacteria,1K9F1@119060|Burkholderiaceae 28216|Betaproteobacteria S STAS domain - - - ko:K07122 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - STAS_2 k59_753892_3 1000565.METUNv1_02421 9.14e-28 105.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,2KW7C@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_469473_1 566466.NOR53_3021 7.51e-59 193.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1J4WP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_398831_1 1028307.EAE_09940 2.52e-67 217.0 COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_255604_1 580332.Slit_0136 1.77e-73 229.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,44VNI@713636|Nitrosomonadales 28216|Betaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_255604_2 1038869.AXAN01000050_gene5905 7.56e-26 99.8 COG1476@1|root,COG1476@2|Bacteria,1NNDC@1224|Proteobacteria,2WGB3@28216|Betaproteobacteria,1KIC7@119060|Burkholderiaceae 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - ko:K15773 - - - - ko00000,ko02048,ko03000 - - - HTH_3 k59_719098_1 1000565.METUNv1_03150 1.51e-102 308.0 COG3240@1|root,COG3240@2|Bacteria,1MWDI@1224|Proteobacteria,2VTBY@28216|Betaproteobacteria,2KXBE@206389|Rhodocyclales 206389|Rhodocyclales I GDSL-like Lipase/Acylhydrolase - - - ko:K12686 - - - - ko00000,ko02000,ko02044 1.B.12.8 - - Lipase_GDSL,VPEP k59_1110810_1 357244.OTBS_0699 7.27e-23 101.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,47ESZ@766|Rickettsiales 766|Rickettsiales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1004726_1 1122951.ATUE01000005_gene1615 8.69e-219 617.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,3NK37@468|Moraxellaceae 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_469480_2 1000565.METUNv1_03384 6.46e-88 263.0 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_469480_3 1000565.METUNv1_03385 2.92e-85 260.0 COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2VJ7E@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - RskA k59_469480_4 1000565.METUNv1_03386 4.99e-53 176.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,2VU7S@28216|Betaproteobacteria,2KWXK@206389|Rhodocyclales 206389|Rhodocyclales FG Histidine triad (HIT) - - - - - - - - - - - - HIT k59_753910_1 1000565.METUNv1_01299 3.76e-05 45.1 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,2KU95@206389|Rhodocyclales 206389|Rhodocyclales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_753910_2 1000565.METUNv1_01298 3.2e-118 341.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,2KVY1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_329003_1 83406.HDN1F_26100 8.62e-65 224.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4R0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - CHASE,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Reg_prop,Response_reg,Y_Y_Y k59_650628_1 1000565.METUNv1_02693 1.03e-161 473.0 COG1181@1|root,COG1181@2|Bacteria,1QWAW@1224|Proteobacteria,2VITI@28216|Betaproteobacteria,2KVT8@206389|Rhodocyclales 206389|Rhodocyclales M Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - - - - - - - - - - - CPSase_L_D2,Mur_ligase_M,RimK k59_753912_1 1000565.METUNv1_01874 3.33e-228 633.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,2KUZG@206389|Rhodocyclales 206389|Rhodocyclales C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_610349_1 1000565.METUNv1_03465 1.19e-20 87.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,2KUMH@206389|Rhodocyclales 206389|Rhodocyclales O protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_610349_2 1000565.METUNv1_03466 1.4e-58 182.0 COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,2VU52@28216|Betaproteobacteria,2KWZX@206389|Rhodocyclales 206389|Rhodocyclales P rhodanese-related sulfurtransferase - - - - - - - - - - - - Rhodanese k59_610349_3 1000565.METUNv1_03467 2.92e-67 218.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,2KUK1@206389|Rhodocyclales 206389|Rhodocyclales MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_255632_1 1000565.METUNv1_00081 4.43e-104 312.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,2KV8R@206389|Rhodocyclales 206389|Rhodocyclales E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_255632_2 1000565.METUNv1_00080 1.52e-91 269.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,2KWCV@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_719121_1 1123504.JQKD01000002_gene3831 1.48e-88 275.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,4A9R2@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase alkK - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_790987_1 1000565.METUNv1_00137 6.1e-297 815.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,2KVFZ@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_790987_2 1000565.METUNv1_00138 4.86e-193 543.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,2KVGS@206389|Rhodocyclales 206389|Rhodocyclales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_790987_3 1000565.METUNv1_00139 8.64e-98 293.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,2KUH4@206389|Rhodocyclales 206389|Rhodocyclales D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_111816_2 365044.Pnap_1032 5.63e-105 308.0 COG0500@1|root,COG2226@2|Bacteria,1QU8Z@1224|Proteobacteria,2VHJ6@28216|Betaproteobacteria 28216|Betaproteobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_111816_3 1000565.METUNv1_02770 6.55e-124 353.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VH4A@28216|Betaproteobacteria,2KVAS@206389|Rhodocyclales 206389|Rhodocyclales J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_111816_4 1523503.JPMY01000017_gene2882 5.03e-34 128.0 COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,1RY43@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2331 k59_898342_1 1000565.METUNv1_03171 0.0 929.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,2KUYH@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1040972_1 365044.Pnap_2322 1.14e-66 205.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,2VQYS@28216|Betaproteobacteria 28216|Betaproteobacteria S Nitrogen fixation protein - - - - - - - - - - - - DUF269 k59_1040972_2 1218076.BAYB01000013_gene2785 2.66e-26 97.8 COG5420@1|root,COG5420@2|Bacteria,1N74Y@1224|Proteobacteria,2VVVF@28216|Betaproteobacteria,1KA9U@119060|Burkholderiaceae 28216|Betaproteobacteria S Rop-like - - - - - - - - - - - - Rop-like k59_1040972_3 269482.Bcep1808_6025 5.44e-56 175.0 COG1143@1|root,COG1143@2|Bacteria,1N1SG@1224|Proteobacteria,2VT6Z@28216|Betaproteobacteria,1KIMV@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein fdxB - - - - - - - - - - - Fer4,Fer4_4 k59_41529_1 338969.Rfer_1479 3.31e-87 266.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,4ABRW@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_436331_2 1538644.KO02_08135 1.64e-16 78.2 COG0019@1|root,COG0019@2|Bacteria,4NE7X@976|Bacteroidetes,1INXN@117747|Sphingobacteriia 976|Bacteroidetes E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_469516_2 497964.CfE428DRAFT_6195 3.55e-67 214.0 COG0673@1|root,COG0673@2|Bacteria,46UE3@74201|Verrucomicrobia 74201|Verrucomicrobia S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_398892_1 194699.Q775D4_BPBPP 3.19e-47 173.0 4QHMX@10239|Viruses,4QW8C@35237|dsDNA viruses no RNA stage,4QRQS@28883|Caudovirales,4QNWI@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_507696_2 497964.CfE428DRAFT_2424 5.06e-34 118.0 COG1141@1|root,COG1141@2|Bacteria,46T2D@74201|Verrucomicrobia 74201|Verrucomicrobia C 4Fe-4S single cluster domain - - - ko:K05337 - - - - ko00000 - - - Fer4_13 k59_719139_1 614083.AWQR01000018_gene1818 1.26e-72 230.0 COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,4AC32@80864|Comamonadaceae 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_719139_2 614083.AWQR01000018_gene1819 1.38e-18 81.6 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VJA0@28216|Betaproteobacteria,4ABV2@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_932238_1 614083.AWQR01000047_gene3306 5.43e-84 261.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4AAPC@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family dbpA GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_1079033_1 468059.AUHA01000003_gene1837 1.81e-32 118.0 COG0664@1|root,COG0664@2|Bacteria,4NRPE@976|Bacteroidetes,1IT2A@117747|Sphingobacteriia 976|Bacteroidetes T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_1079033_2 1122176.KB903532_gene2557 7.9e-54 177.0 COG1418@1|root,COG1418@2|Bacteria,4NFAG@976|Bacteroidetes,1ISTR@117747|Sphingobacteriia 976|Bacteroidetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - Guanylate_cyc,HD k59_1004810_1 1538295.JY96_10425 5.09e-110 322.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KJGM@119065|unclassified Burkholderiales 28216|Betaproteobacteria P transport system permease potH - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_1040999_1 1538295.JY96_11055 4.55e-44 162.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2W1GY@28216|Betaproteobacteria,1KPE8@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_7,PAS_8,Response_reg k59_291769_1 1000565.METUNv1_00763 2.26e-128 370.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,2KUAU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1079056_1 794903.OPIT5_25110 3.97e-36 143.0 COG1345@1|root,COG1345@2|Bacteria,46U2K@74201|Verrucomicrobia,3K76A@414999|Opitutae 414999|Opitutae N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_507729_1 1366050.N234_15495 1.45e-24 98.6 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,1K2GD@119060|Burkholderiaceae 28216|Betaproteobacteria P Sulfurtransferase sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_329099_1 1000565.METUNv1_02870 7.84e-131 394.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,2KVTG@206389|Rhodocyclales 206389|Rhodocyclales D DNA segregation ATPase FtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_329102_1 1121035.AUCH01000006_gene680 1.89e-50 166.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,2KW3W@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_329102_2 1000565.METUNv1_02991 0.000273 45.4 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,2KWHK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_5055_1 1000565.METUNv1_03636 7.41e-116 336.0 28P5Y@1|root,2ZC0T@2|Bacteria,1RBDV@1224|Proteobacteria,2VZTY@28216|Betaproteobacteria,2KYJ2@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_5055_2 1000565.METUNv1_03635 1.13e-297 837.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KW95@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_41562_1 1384056.N787_01460 2.31e-17 87.8 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE4,EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_9,dCache_3 k59_76795_1 1000565.METUNv1_03450 9.04e-190 538.0 COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,2KV8I@206389|Rhodocyclales 206389|Rhodocyclales CI Bifunctional enoyl-CoA hydratase phosphate acetyltransferase pta - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas,PTA_PTB k59_76795_2 1000565.METUNv1_03449 3.81e-12 65.5 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,2KUC3@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction - - - - - - - - - - - - Acetate_kinase k59_41566_1 1000565.METUNv1_01875 3.32e-59 191.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,2KV2D@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_329124_1 62928.azo1514 2.26e-83 259.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KV17@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_329124_2 666681.M301_0036 4.74e-14 70.5 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KKR6@206350|Nitrosomonadales 206350|Nitrosomonadales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1004866_1 1000565.METUNv1_03381 5.93e-117 349.0 2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria,2KVGT@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_398955_1 232721.Ajs_2017 3.55e-66 228.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4AG5R@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - DUF4118,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_753974_1 349521.HCH_04493 8.58e-38 141.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1XHZJ@135619|Oceanospirillales 135619|Oceanospirillales T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - DUF3391,HD,HD_5 k59_1110887_1 375286.mma_0451 9.35e-67 211.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,475V5@75682|Oxalobacteraceae 28216|Betaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA soxA - - ko:K17222 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - - k59_41584_1 1000565.METUNv1_03167 4.73e-68 207.0 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria 28216|Betaproteobacteria T Pfam Response regulator receiver - - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_41584_2 1000565.METUNv1_03168 1.14e-46 167.0 COG0642@1|root,COG2205@2|Bacteria,1R8EX@1224|Proteobacteria,2VSAK@28216|Betaproteobacteria 28216|Betaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_9 k59_754570_2 313606.M23134_02781 1.84e-17 87.8 COG0840@1|root,COG2202@1|root,COG3850@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,COG3850@2|Bacteria,4NHQZ@976|Bacteroidetes,47PHP@768503|Cytophagia 976|Bacteroidetes T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2 k59_610746_1 1523503.JPMY01000046_gene1315 2.22e-85 276.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_509058_1 1120963.KB894491_gene673 6.41e-67 212.0 COG0834@1|root,COG0834@2|Bacteria,1RBXC@1224|Proteobacteria,1S31V@1236|Gammaproteobacteria,2Q3E6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_147861_1 1000565.METUNv1_04045 1.86e-117 380.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,2KXC4@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - ESPR,Haemagg_act k59_77915_1 395495.Lcho_4136 4.61e-57 189.0 COG2010@1|root,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria,1KNJH@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,DUF302 k59_1010776_2 748247.AZKH_0615 3.23e-22 91.3 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,2VM7I@28216|Betaproteobacteria,2KVDE@206389|Rhodocyclales 206389|Rhodocyclales H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids cobO - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Co_AT_N,CobA_CobO_BtuR k59_544887_1 990285.RGCCGE502_18645 7.73e-10 58.9 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSGN@28211|Alphaproteobacteria,4B8AV@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC-type sugar transport systems, permease components ugpA - - ko:K05814 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_544887_2 1336208.JADY01000008_gene2232 2.75e-35 132.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TQKV@28211|Alphaproteobacteria,2JPHX@204441|Rhodospirillales 204441|Rhodospirillales G Bacterial extracellular solute-binding protein - - - ko:K05813 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - SBP_bac_8 k59_796997_1 1000565.METUNv1_02423 1.26e-121 352.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,2KVD2@206389|Rhodocyclales 206389|Rhodocyclales V ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_46834_1 312153.Pnuc_1149 2.16e-17 86.7 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,1K3NJ@119060|Burkholderiaceae 28216|Betaproteobacteria U family outer membrane protein - - - - - - - - - - - - ESPR,Glug,Haemagg_act k59_660054_1 1349767.GJA_3902 1.63e-32 130.0 COG0457@1|root,COG2203@1|root,COG4191@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,475JP@75682|Oxalobacteraceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c k59_153126_1 640081.Dsui_1203 8.56e-36 132.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2VNC5@28216|Betaproteobacteria,2KWES@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1087921_1 614083.AWQR01000018_gene1920 1.99e-85 259.0 COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,2VRH7@28216|Betaproteobacteria,4AG9U@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) thiM - 2.7.1.50 ko:K00878 ko00730,ko01100,map00730,map01100 M00127 R04448 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HK k59_724110_1 886293.Sinac_2441 5.55e-88 273.0 COG4102@1|root,COG4102@2|Bacteria,2IY49@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_297919_1 1485544.JQKP01000002_gene1648 1.52e-18 85.1 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2VQR7@28216|Betaproteobacteria,44VJ8@713636|Nitrosomonadales 28216|Betaproteobacteria O Glycoprotease family yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_297919_2 626418.bglu_1g12460 2.57e-08 54.3 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2VUIW@28216|Betaproteobacteria,1K2XJ@119060|Burkholderiaceae 28216|Betaproteobacteria K Ribosomal-protein-alanine acetyltransferase rimI - 2.3.1.128 ko:K03789,ko:K14742 - - - - ko00000,ko01000,ko03009,ko03016 - - - Acetyltransf_1,Peptidase_M22 k59_516637_1 930169.B5T_01911 2.67e-09 58.2 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1XHAM@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_516637_3 399739.Pmen_4213 1.42e-125 361.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,1YCUA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422 Thymidylat_synt k59_1087931_1 1122605.KB893648_gene3659 9.9e-36 136.0 COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes,1INRQ@117747|Sphingobacteriia 976|Bacteroidetes S glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_516647_1 1000565.METUNv1_04024 2.61e-104 317.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,2KUSS@206389|Rhodocyclales 206389|Rhodocyclales L Single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_46867_1 1000565.METUNv1_02931 1.32e-71 219.0 2BG6F@1|root,32A39@2|Bacteria,1RI4Y@1224|Proteobacteria,2VT9E@28216|Betaproteobacteria,2KWET@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_724131_1 38833.XP_003059429.1 4.86e-07 57.8 KOG1032@1|root,KOG1032@2759|Eukaryota,37IJ8@33090|Viridiplantae,34M0A@3041|Chlorophyta 3041|Chlorophyta S domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins - - - - - - - - - - - - DUF4782,GRAM k59_261342_2 335283.Neut_1972 1.94e-33 119.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2VRIB@28216|Betaproteobacteria,3732K@32003|Nitrosomonadales 28216|Betaproteobacteria S EVE domain - - - - - - - - - - - - EVE k59_475072_1 292415.Tbd_0297 5.59e-109 328.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,1KSY0@119069|Hydrogenophilales 119069|Hydrogenophilales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_475072_2 1123367.C666_00180 3.78e-54 183.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,2KVNW@206389|Rhodocyclales 206389|Rhodocyclales H Capsular polysaccharide biosynthesis protein CapK - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_195341_1 338969.Rfer_0702 7.35e-88 271.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,4ACXV@80864|Comamonadaceae 28216|Betaproteobacteria M Bacterial sugar transferase wcaJ - 2.7.8.40 ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_1115356_2 1198452.Jab_2c30370 9.2e-50 165.0 COG0834@1|root,COG0834@2|Bacteria,1RH2S@1224|Proteobacteria,2VTUM@28216|Betaproteobacteria,475PR@75682|Oxalobacteraceae 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_797079_1 614083.AWQR01000009_gene548 1.1e-51 180.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJMS@28216|Betaproteobacteria,4AB06@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_797079_2 1532557.JL37_10925 3.28e-20 88.6 COG1804@1|root,COG1804@2|Bacteria,1MU5U@1224|Proteobacteria,2VJB6@28216|Betaproteobacteria,3T66J@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_369009_1 1177181.T9A_00284 2.78e-24 106.0 COG0642@1|root,COG0745@1|root,COG2203@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XNNU@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_46892_1 929713.NIASO_02710 7.67e-129 374.0 COG0673@1|root,COG0673@2|Bacteria,4NEC6@976|Bacteroidetes,1IX1W@117747|Sphingobacteriia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_687291_1 365044.Pnap_2096 9.58e-87 269.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,4AB30@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_475085_1 1000565.METUNv1_02497 1.72e-39 132.0 COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,2KXDM@206389|Rhodocyclales 206389|Rhodocyclales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_475085_2 1000565.METUNv1_02496 1.16e-170 481.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,2KV0J@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_516718_1 1415779.JOMH01000001_gene309 8.6e-47 152.0 COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,1SDB7@1236|Gammaproteobacteria,1X7ZI@135614|Xanthomonadales 135614|Xanthomonadales S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_1046180_1 1000565.METUNv1_03566 8.92e-108 316.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,2KV6V@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_1046180_2 1000565.METUNv1_03565 1.35e-36 128.0 COG1335@1|root,COG1335@2|Bacteria,1MWFQ@1224|Proteobacteria,2VKV5@28216|Betaproteobacteria,2KXVG@206389|Rhodocyclales 206389|Rhodocyclales Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_833407_1 1122951.ATUE01000005_gene1882 8.78e-60 189.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,3NJTB@468|Moraxellaceae 1236|Gammaproteobacteria P Belongs to the Fur family zur - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_798197_1 1504672.669782951 3.32e-114 350.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,4A9VA@80864|Comamonadaceae 28216|Betaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_580492_1 267608.RSp1341 1.41e-75 234.0 COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,2VRS9@28216|Betaproteobacteria,1K1ND@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_11439_2 1120945.ATUW01000002_gene1881 1.1e-08 56.6 COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,4D5U8@85005|Actinomycetales 201174|Actinobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_11439_5 1288298.rosmuc_02356 3.66e-13 68.9 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,46QRG@74030|Roseovarius 28211|Alphaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_370195_1 591158.SSMG_04001 7.19e-20 84.3 COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria 201174|Actinobacteria J 50S ribosomal protein L31 rpmE2 - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_47828_1 1000565.METUNv1_00921 2.07e-106 319.0 COG2200@1|root,COG2200@2|Bacteria,1PDZY@1224|Proteobacteria,2VM72@28216|Betaproteobacteria,2KURH@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL k59_47828_2 365044.Pnap_4513 6.92e-57 197.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_447367_1 159087.Daro_1699 7.42e-148 422.0 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,2VJUF@28216|Betaproteobacteria,2KVU8@206389|Rhodocyclales 206389|Rhodocyclales S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_759298_1 614083.AWQR01000048_gene3213 2.49e-161 471.0 COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,4AAMN@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Orn Lys Arg decarboxylase major region adi - 4.1.1.19 ko:K01584 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N k59_1116385_1 391612.CY0110_25486 7.51e-48 176.0 COG0642@1|root,COG2202@1|root,COG3899@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GD97@1117|Cyanobacteria,3KHHW@43988|Cyanothece 1117|Cyanobacteria T Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Response_reg k59_196903_1 1000565.METUNv1_02815 1.22e-72 240.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VHGG@28216|Betaproteobacteria,2KUZQ@206389|Rhodocyclales 206389|Rhodocyclales M Family 2 glycosyl transferase - - - - - - - - - - - - Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2 k59_798221_1 1198452.Jab_2c09570 7.82e-52 171.0 2DBQT@1|root,2ZAGN@2|Bacteria,1RKZ3@1224|Proteobacteria,2VNUF@28216|Betaproteobacteria,478MU@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_973540_1 1353529.M899_2120 2.93e-22 94.7 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2MSUI@213481|Bdellovibrionales,2WJQ2@28221|Deltaproteobacteria 213481|Bdellovibrionales H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_973540_2 1201290.M902_2769 1.33e-18 87.8 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2MSZP@213481|Bdellovibrionales,2WJ5V@28221|Deltaproteobacteria 213481|Bdellovibrionales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1011670_1 926549.KI421517_gene2001 5.79e-78 251.0 COG0477@1|root,COG2814@2|Bacteria,4NESW@976|Bacteroidetes,47JIH@768503|Cytophagia 976|Bacteroidetes EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_798234_1 614083.AWQR01000013_gene1650 1.7e-46 154.0 COG2867@1|root,COG2867@2|Bacteria,1RI5E@1224|Proteobacteria 1224|Proteobacteria I negative regulation of translational initiation - - - - - - - - - - - - Polyketide_cyc2 k59_759316_1 1000565.METUNv1_03879 2.41e-166 483.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,2KV0N@206389|Rhodocyclales 206389|Rhodocyclales E Oligopeptidase prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_688199_1 296591.Bpro_3605 1.01e-28 112.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,4AAV3@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_688199_2 614083.AWQR01000010_gene1565 2.58e-102 308.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,4AAWB@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_47864_1 1000565.METUNv1_03061 1.88e-159 453.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,2KUKQ@206389|Rhodocyclales 206389|Rhodocyclales S protein containing LysM domain - - - - - - - - - - - - LysM k59_83127_1 1562701.BBOF01000052_gene1640 7.72e-17 81.6 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2VHQ5@28216|Betaproteobacteria,1K0QA@119060|Burkholderiaceae 28216|Betaproteobacteria NU PFAM H transporting two-sector ATPase alpha beta subunit central region - - 3.6.3.14 ko:K03224 ko03070,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.6.1,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_798249_1 1121373.KB903627_gene2930 4.46e-59 188.0 COG0118@1|root,COG0118@2|Bacteria,4NF4J@976|Bacteroidetes,47P9A@768503|Cytophagia 976|Bacteroidetes E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_904822_3 1121456.ATVA01000014_gene632 1.65e-54 189.0 COG1783@1|root,COG1783@2|Bacteria,1RAGC@1224|Proteobacteria,42Z29@68525|delta/epsilon subdivisions,2WTUP@28221|Deltaproteobacteria,2MCJK@213115|Desulfovibrionales 28221|Deltaproteobacteria S phage Terminase large subunit - - - - - - - - - - - - - k59_404325_1 1000565.METUNv1_00211 3.29e-96 296.0 COG5000@1|root,COG5000@2|Bacteria,1QVAT@1224|Proteobacteria,2WGR4@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_725184_1 765913.ThidrDRAFT_2466 1.18e-13 77.4 COG1196@1|root,COG5002@1|root,COG1196@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1ND@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_196978_1 344747.PM8797T_19141 3.13e-62 208.0 COG0337@1|root,COG0337@2|Bacteria,2IXAM@203682|Planctomycetes 203682|Planctomycetes E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_299082_1 595537.Varpa_0001 6.77e-82 258.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,4AAHN@80864|Comamonadaceae 28216|Betaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_833464_1 640081.Dsui_1890 4.17e-68 231.0 COG3437@1|root,COG5001@1|root,COG3437@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVQ2@206389|Rhodocyclales 206389|Rhodocyclales T Response regulator receiver modulated diguanylate cyclase phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_8,Response_reg k59_1116436_2 395494.Galf_2354 2.07e-52 170.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2VQ6H@28216|Betaproteobacteria,44WB7@713636|Nitrosomonadales 28216|Betaproteobacteria KT PFAM PAS fold domain protein - - - - - - - - - - - - PAS_3 k59_83142_1 1198452.Jab_2c25220 2.2e-173 498.0 COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,2WBF8@28216|Betaproteobacteria,475PG@75682|Oxalobacteraceae 28216|Betaproteobacteria S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 k59_725207_2 1000565.METUNv1_03041 6e-30 107.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,2KWYD@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_759363_1 90814.KL370891_gene218 6.2e-48 169.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RS2E@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - HD,HD_5 k59_904842_3 1116375.VEJY3_09830 3.02e-15 74.3 COG3613@1|root,COG3613@2|Bacteria,1NB40@1224|Proteobacteria,1SCJ5@1236|Gammaproteobacteria,1XZ2K@135623|Vibrionales 135623|Vibrionales F Domain of unknown function (DUF4406) - - - - - - - - - - - - DUF4406 k59_833498_1 1090318.ATTI01000001_gene910 2.9e-08 61.2 COG2159@1|root,COG2159@2|Bacteria,1QKBY@1224|Proteobacteria,2U2UB@28211|Alphaproteobacteria,2K9VY@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_447538_2 1454004.AW11_03806 3.38e-40 148.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2VHSJ@28216|Betaproteobacteria 28216|Betaproteobacteria V Type I secretion system prtD - - ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran k59_546082_1 1000565.METUNv1_01509 1.59e-33 117.0 COG1977@1|root,COG1977@2|Bacteria,1QVHT@1224|Proteobacteria,2WGRV@28216|Betaproteobacteria,2KZQI@206389|Rhodocyclales 206389|Rhodocyclales H Mut7-C ubiquitin - - - - - - - - - - - - ThiS k59_1046265_1 1502852.FG94_04264 2.2e-32 122.0 2C0PG@1|root,330E3@2|Bacteria,1RA6M@1224|Proteobacteria,2VW6R@28216|Betaproteobacteria,474E0@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_370321_1 1198452.Jab_1c01890 1.55e-21 90.9 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VR1X@28216|Betaproteobacteria,476K4@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_370321_2 1198452.Jab_1c01880 1.2e-69 216.0 COG0625@1|root,COG0625@2|Bacteria,1NX28@1224|Proteobacteria,2VQ5Y@28216|Betaproteobacteria,4772Y@75682|Oxalobacteraceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain yfcF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_4,GST_N,GST_N_3 k59_733601_1 296591.Bpro_3491 5.82e-55 191.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_733601_2 1504672.669787191 6.58e-85 269.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,4ACXX@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_1060311_1 1000565.METUNv1_00838 5.39e-57 204.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KV2V@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_982493_1 1380600.AUYN01000009_gene1814 6.31e-55 190.0 COG0323@1|root,COG0323@2|Bacteria,4NDWJ@976|Bacteroidetes,1HWX8@117743|Flavobacteriia 976|Bacteroidetes L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_210255_2 1122603.ATVI01000006_gene654 8.02e-63 202.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X88E@135614|Xanthomonadales 135614|Xanthomonadales E alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_556222_1 1163617.SCD_n00193 3.32e-15 77.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family czcD1 - - - - - - - - - - - Cation_efflux,ZT_dimer k59_556222_2 748247.AZKH_0679 5.2e-26 99.8 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,2KWCV@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_676281_1 1123248.KB893348_gene153 6.87e-09 55.5 COG1280@1|root,COG1280@2|Bacteria,4NH3F@976|Bacteroidetes,1ITSR@117747|Sphingobacteriia 976|Bacteroidetes E Lysine exporter protein (Lyse ygga) - - - - - - - - - - - - LysE k59_310016_1 857087.Metme_1126 1.36e-17 80.1 COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,1S48U@1236|Gammaproteobacteria,1XFI1@135618|Methylococcales 135618|Methylococcales K RNA polymerase sigma factor 70, region 4 type 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_354338_1 305700.B447_18904 1.69e-29 111.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ32@28216|Betaproteobacteria,2KY0E@206389|Rhodocyclales 206389|Rhodocyclales K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_354338_2 522306.CAP2UW1_0306 3.44e-37 128.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,2VJ9U@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - ko:K05796 - - - - ko00000 - - - Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9 k59_1020689_1 1123279.ATUS01000003_gene393 3.89e-57 196.0 COG0304@1|root,COG0304@2|Bacteria,1MV67@1224|Proteobacteria,1RMXJ@1236|Gammaproteobacteria,1J4UN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - Ketoacyl-synt_C,ketoacyl-synt k59_91981_1 640081.Dsui_0261 4.71e-73 228.0 COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,2KVPE@206389|Rhodocyclales 206389|Rhodocyclales P Bacterial extracellular solute-binding protein cysP - - ko:K02048 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - SBP_bac_11 k59_91981_2 261292.Nit79A3_0994 1.34e-39 139.0 COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,372C9@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component cysT - - ko:K02046,ko:K15496 ko00920,ko02010,map00920,map02010 M00185,M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.6.5 - - BPD_transp_1 k59_461519_1 339670.Bamb_4304 8.66e-52 180.0 COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,2VJAK@28216|Betaproteobacteria,1KH0K@119060|Burkholderiaceae 28216|Betaproteobacteria CH PFAM monooxygenase FAD-binding - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_56857_1 1120999.JONM01000003_gene2616 3.98e-42 159.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KSJX@206351|Neisseriales 206351|Neisseriales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_556245_1 1121920.AUAU01000013_gene1753 1.86e-103 314.0 COG2509@1|root,COG2509@2|Bacteria 2|Bacteria H 5-formyltetrahydrofolate cyclo-ligase activity IV02_08645 - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,HI0933_like,Pyr_redox_2 k59_91990_1 1121940.AUDZ01000013_gene812 1.95e-09 58.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XHFG@135619|Oceanospirillales 135619|Oceanospirillales T regulator hydG - - - - - - - - - - - Response_reg,Sigma54_activat k59_842745_1 702113.PP1Y_AT23638 7.39e-68 221.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2TQQQ@28211|Alphaproteobacteria,2K34Z@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_733654_1 1000565.METUNv1_01547 3.43e-133 385.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,2KUTE@206389|Rhodocyclales 206389|Rhodocyclales C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_210284_1 221288.JH992901_gene3925 6.58e-23 102.0 COG1404@1|root,COG1404@2|Bacteria,1G1G8@1117|Cyanobacteria,1JHUG@1189|Stigonemataceae 1117|Cyanobacteria O Subtilase family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_272165_1 1209072.ALBT01000033_gene1597 9.59e-62 203.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1FGRA@10|Cellvibrio 1236|Gammaproteobacteria T Histidine kinase algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_1094461_1 1198452.Jab_2c20990 2.6e-44 160.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,473VR@75682|Oxalobacteraceae 28216|Betaproteobacteria NT PFAM HAMP domain, Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_163456_2 1123248.KB893314_gene3641 4.07e-12 66.6 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,1IPPT@117747|Sphingobacteriia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_533198_1 1356854.N007_16575 7.75e-07 50.8 COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HBSC@91061|Bacilli,279KU@186823|Alicyclobacillaceae 91061|Bacilli K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_533198_2 1121920.AUAU01000016_gene1302 5.82e-67 204.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 k59_877600_1 93220.LV28_01895 1.55e-48 166.0 COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VKAX@28216|Betaproteobacteria,1K3UW@119060|Burkholderiaceae 28216|Betaproteobacteria S Chromate resistance chrB - - - - - - - - - - - Chrome_Resist k59_807341_2 29581.BW37_00029 4.47e-43 152.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,472UD@75682|Oxalobacteraceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_92034_1 1100720.ALKN01000045_gene208 4.95e-103 327.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,4AAFE@80864|Comamonadaceae 28216|Betaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_127379_1 1122951.ATUE01000012_gene517 9.13e-110 349.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,3NJ1H@468|Moraxellaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_588070_1 1397528.Q671_08880 3.15e-39 141.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1XH95@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_912653_1 700598.Niako_1029 2e-107 325.0 COG0308@1|root,COG0308@2|Bacteria,4NGUB@976|Bacteroidetes,1IWD6@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_354470_1 215803.DB30_2024 4.51e-24 100.0 COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,42W0U@68525|delta/epsilon subdivisions,2X5C0@28221|Deltaproteobacteria,2Z351@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1020770_1 243365.CV_0292 3.22e-85 270.0 COG0737@1|root,COG0737@2|Bacteria,1MU11@1224|Proteobacteria,2VJC2@28216|Betaproteobacteria,2KQCH@206351|Neisseriales 206351|Neisseriales F 5'-nucleotidase, C-terminal domain cpdB - 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 - R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_1124538_1 1000565.METUNv1_03313 3.45e-80 254.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,2KUXG@206389|Rhodocyclales 206389|Rhodocyclales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1124538_2 1000565.METUNv1_03312 3.31e-33 120.0 COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,2KWVJ@206389|Rhodocyclales 206389|Rhodocyclales D cell division protein ftsN - - - - - - - - - - - SPOR k59_733705_1 1449049.JONW01000011_gene2127 4.05e-106 313.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,2KG1I@204458|Caulobacterales 204458|Caulobacterales I PFAM Enoyl-CoA hydratase isomerase - - - - - - - - - - - - ECH_1 k59_982587_1 1198452.Jab_2c02430 2.73e-91 289.0 COG3391@1|root,COG3391@2|Bacteria,1PGUU@1224|Proteobacteria,2WAW5@28216|Betaproteobacteria,476SP@75682|Oxalobacteraceae 28216|Betaproteobacteria S NHL repeat - - - - - - - - - - - - NHL k59_982598_1 935840.JAEQ01000030_gene856 8.47e-101 303.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,43HFQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Sodium Bile acid symporter family arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_1020796_1 1485543.JMME01000002_gene1806 2.2e-16 82.4 COG2208@1|root,COG5000@1|root,COG2208@2|Bacteria,COG5000@2|Bacteria,1TS3B@1239|Firmicutes 1239|Firmicutes T response regulator - - - - - - - - - - - - HAMP,SpoIIE,dCache_1 k59_556345_1 1496688.ER33_03075 4.13e-07 51.2 COG0668@1|root,COG0668@2|Bacteria,1G1I3@1117|Cyanobacteria 1117|Cyanobacteria M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_310144_1 365046.Rta_21145 8.98e-49 161.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,4ADGX@80864|Comamonadaceae 28216|Betaproteobacteria D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_310144_2 232721.Ajs_1914 2.04e-21 92.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,4AA30@80864|Comamonadaceae 28216|Betaproteobacteria J ribonuclease, Rne Rng family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_92091_1 232721.Ajs_2725 4.6e-44 148.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,4AAAY@80864|Comamonadaceae 28216|Betaproteobacteria KT PFAM response regulator receiver copR - - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_92091_2 399795.CtesDRAFT_PD0898 1.26e-21 94.7 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2WGGV@28216|Betaproteobacteria,4ABHH@80864|Comamonadaceae 28216|Betaproteobacteria T Member of a two-component regulatory system copS - 2.7.13.3 ko:K07644 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA k59_982604_1 404380.Gbem_1815 9.66e-37 134.0 COG1657@1|root,COG1657@2|Bacteria,1RDNW@1224|Proteobacteria,42S7H@68525|delta/epsilon subdivisions,2WNQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Prenyltransferase squalene oxidase - - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - Prenyltrans k59_533312_1 445972.ANACOL_00900 1.04e-46 169.0 COG0574@1|root,COG0574@2|Bacteria,1UJVW@1239|Firmicutes,24ASB@186801|Clostridia 186801|Clostridia G Pyruvate phosphate dikinase, PEP pyruvate binding domain protein - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_272250_1 1223521.BBJX01000006_gene1695 1.72e-44 147.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,4ADW1@80864|Comamonadaceae 28216|Betaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_380323_1 614083.AWQR01000053_gene3381 1.37e-35 132.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,2VI6Y@28216|Betaproteobacteria,4AC8A@80864|Comamonadaceae 28216|Betaproteobacteria I Phosphate acyltransferases yihG - - - - - - - - - - - Acyltransferase k59_356796_1 159087.Daro_0532 6.03e-90 266.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,2VQ18@28216|Betaproteobacteria,2KW3V@206389|Rhodocyclales 206389|Rhodocyclales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_356796_2 159087.Daro_0531 5.48e-17 74.3 COG1917@1|root,COG1917@2|Bacteria,1N0MR@1224|Proteobacteria,2VVE1@28216|Betaproteobacteria 28216|Betaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - AraC_binding,Cupin_2 k59_844340_1 1100721.ALKO01000015_gene1074 5.55e-115 343.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,4AB6G@80864|Comamonadaceae 28216|Betaproteobacteria I Poly(R)-hydroxyalkanoic acid synthase, class I phbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_734880_1 997884.HMPREF1068_03415 5.28e-30 120.0 COG1215@1|root,COG1215@2|Bacteria,4NESG@976|Bacteroidetes,2FN9E@200643|Bacteroidia,4AKQR@815|Bacteroidaceae 976|Bacteroidetes M Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_878965_1 1000565.METUNv1_02227 1.24e-147 430.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2VS73@28216|Betaproteobacteria,2KYUR@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain ragB - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HAMP,HATPase_c k59_878965_2 1000565.METUNv1_02228 2.68e-91 276.0 COG0421@1|root,COG0421@2|Bacteria,1RJUC@1224|Proteobacteria,2WE7T@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1022240_1 1500894.JQNN01000001_gene247 9.6e-33 128.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2VH2B@28216|Betaproteobacteria,4745E@75682|Oxalobacteraceae 28216|Betaproteobacteria V MatE norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_128731_1 1349767.GJA_3482 3.48e-56 184.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,4724Z@75682|Oxalobacteraceae 28216|Betaproteobacteria S AFG1-like ATPase yhcM - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_164864_1 1120985.AUMI01000016_gene2019 3.57e-30 126.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1UYZX@1239|Firmicutes,4H9ID@909932|Negativicutes 909932|Negativicutes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg,SBP_bac_3 k59_21876_1 1000565.METUNv1_03766 2.47e-69 228.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,2VJKQ@28216|Betaproteobacteria,2KV2F@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_21876_2 1000565.METUNv1_03767 1.03e-137 406.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase group 1 - - - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1,Kdo k59_273582_1 1177154.Y5S_01256 4.87e-101 305.0 2DB8Y@1|root,2Z7TF@2|Bacteria,1MW4C@1224|Proteobacteria,1RQC5@1236|Gammaproteobacteria,1XNWN@135619|Oceanospirillales 135619|Oceanospirillales S Uncharacterized protein conserved in bacteria (DUF2236) - - - - - - - - - - - - DUF2236 k59_356853_1 232721.Ajs_1126 1.67e-46 161.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VJNN@28216|Betaproteobacteria,4A9S2@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128,ko:K22187 ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_487909_1 1122604.JONR01000015_gene198 3.35e-80 247.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RNDU@1236|Gammaproteobacteria,1X9PD@135614|Xanthomonadales 135614|Xanthomonadales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_913828_1 667015.Bacsa_2052 1.03e-69 222.0 COG2234@1|root,COG2234@2|Bacteria,4NG2A@976|Bacteroidetes,2FN1C@200643|Bacteroidia,4AKTJ@815|Bacteroidaceae 976|Bacteroidetes S glutaminyl-peptide cyclotransferase (glutaminyl cyclase) K00683 ywaD - - - - - - - - - - - Peptidase_M28 k59_423373_1 349966.DJ58_2795 1.25e-18 91.7 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,1RP7J@1236|Gammaproteobacteria,41DW0@629|Yersinia 1236|Gammaproteobacteria G deacetyl_PgaB poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB pgaB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016787,GO:0016810,GO:0043170,GO:0043412,GO:0071704,GO:0098732 - ko:K11931,ko:K21478 ko02026,map02026 - R03096 RC00010 ko00000,ko00001,ko01000 - - - GHL13,Polysacc_deac_1 k59_630575_1 236097.ADG881_3008 5.8e-91 275.0 COG1352@1|root,COG1352@2|Bacteria,1NQTI@1224|Proteobacteria,1RS9Z@1236|Gammaproteobacteria,1XMET@135619|Oceanospirillales 135619|Oceanospirillales NT chemotaxis - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_778183_1 1122951.ATUE01000007_gene797 2.57e-41 152.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,3NIGC@468|Moraxellaceae 1236|Gammaproteobacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_778183_2 546274.EIKCOROL_02184 4.1e-27 104.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,2KQ3U@206351|Neisseriales 206351|Neisseriales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_598847_1 1000565.METUNv1_00410 5.72e-58 184.0 2BCK1@1|root,32662@2|Bacteria,1RHH4@1224|Proteobacteria,2VSPG@28216|Betaproteobacteria,2KXB5@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_994410_2 1100721.ALKO01000029_gene66 3.84e-30 109.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,4ADH4@80864|Comamonadaceae 28216|Betaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_139632_1 572477.Alvin_0687 2.53e-32 131.0 COG1629@1|root,COG4771@2|Bacteria,1RKNG@1224|Proteobacteria,1RQYA@1236|Gammaproteobacteria,1X2B6@135613|Chromatiales 135613|Chromatiales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_994429_1 1392488.JHZY01000003_gene3712 3.01e-35 141.0 COG2911@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,4PHW2@976|Bacteroidetes,1IG6W@117743|Flavobacteriia,2XJV6@283735|Leeuwenhoekiella 976|Bacteroidetes MQ Domains in Na-Ca exchangers and integrin-beta4 - - - - - - - - - - - - Calx-beta k59_176872_1 1123393.KB891333_gene2619 2.6e-48 162.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VQID@28216|Betaproteobacteria 28216|Betaproteobacteria S phospholipase Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_241620_1 1000565.METUNv1_02651 2.75e-109 335.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,2KVUK@206389|Rhodocyclales 206389|Rhodocyclales N Belongs to the flagella basal body rod proteins family flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_713020_1 1000565.METUNv1_00838 2.16e-26 107.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KV2V@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_713020_2 1000565.METUNv1_00837 1.23e-99 302.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,2KVE3@206389|Rhodocyclales 206389|Rhodocyclales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_927083_1 398578.Daci_1933 7.46e-69 219.0 COG0305@1|root,COG0305@2|Bacteria,1PP51@1224|Proteobacteria,2VQ9Z@28216|Betaproteobacteria 28216|Betaproteobacteria L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C k59_959289_1 640081.Dsui_3159 2.33e-35 137.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,2KUUR@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase dctS - 2.7.13.3 ko:K11711 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS k59_782194_1 485918.Cpin_1463 1.55e-37 139.0 COG4299@1|root,COG4299@2|Bacteria,4NDZF@976|Bacteroidetes,1IVXC@117747|Sphingobacteriia 976|Bacteroidetes S COGs COG4299 conserved - - - - - - - - - - - - DUF1624,DUF5009 k59_713038_1 1408473.JHXO01000015_gene1925 0.000737 48.9 COG2247@1|root,COG2911@1|root,COG4733@1|root,COG2247@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4PHY6@976|Bacteroidetes,2FTM3@200643|Bacteroidia 976|Bacteroidetes M cellulase activity - - - - - - - - - - - - - k59_633704_2 340177.Cag_0301 1.95e-60 210.0 COG0457@1|root,COG0859@1|root,COG1912@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,COG1912@2|Bacteria,1FDZ8@1090|Chlorobi 1090|Chlorobi M S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_245524_1 1226994.AMZB01000104_gene1408 4e-14 77.8 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YCZY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - 2.7.13.3 ko:K02030,ko:K07679 ko02020,ko05133,map02020,map05133 M00236,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - CHASE,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_1141005_1 1122951.ATUE01000008_gene287 1.5e-132 384.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,3NNF1@468|Moraxellaceae 1236|Gammaproteobacteria C N-terminal domain of cytochrome oxidase-cbb3, FixP ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iJN746.PP_4253 Cytochrome_CBB3,FixP_N k59_782305_1 1112274.KI911560_gene1634 8.7e-151 430.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KKKJ@206350|Nitrosomonadales 206350|Nitrosomonadales S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_998514_1 582744.Msip34_1696 6.79e-110 346.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KM51@206350|Nitrosomonadales 206350|Nitrosomonadales V Hydrophobe Amphiphile Efflux-1 (HAE1) Family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_713177_3 1198452.Jab_2c16500 1.15e-58 189.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,4726S@75682|Oxalobacteraceae 28216|Betaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_602580_1 1123487.KB892866_gene1729 1.12e-99 298.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VJFX@28216|Betaproteobacteria,2KX50@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_998531_1 402626.Rpic_4468 2.53e-52 185.0 COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,2VMKQ@28216|Betaproteobacteria,1K5CU@119060|Burkholderiaceae 28216|Betaproteobacteria H TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_633863_1 987059.RBXJA2T_02986 0.000901 41.2 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KJHG@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_633863_2 397945.Aave_4368 7.67e-105 312.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,4AAQR@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family thlA_2 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_426712_1 670292.JH26_26455 2.27e-06 51.6 COG3840@1|root,COG3840@2|Bacteria,1MV78@1224|Proteobacteria,2U6N3@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system thiQ - - ko:K02062 ko02010,map02010 M00191 - - ko00000,ko00001,ko00002,ko02000 3.A.1.19 - - ABC_tran k59_426712_2 436717.AOLE_08155 7.01e-44 152.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,3NJ2A@468|Moraxellaceae 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_998565_1 1123070.KB899265_gene1839 1.46e-32 129.0 COG4972@1|root,COG4972@2|Bacteria,46UI7@74201|Verrucomicrobia,2ITTF@203494|Verrucomicrobiae 203494|Verrucomicrobiae NU Type IV pilus assembly protein PilM; - - - - - - - - - - - - PilM_2 k59_782375_1 338969.Rfer_1721 1.68e-56 187.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,4AA5K@80864|Comamonadaceae 28216|Betaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_782375_2 1100721.ALKO01000021_gene699 0.000117 43.5 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,4ABA7@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 ppaX - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_245640_1 926549.KI421517_gene3978 7.1e-42 156.0 COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,47KES@768503|Cytophagia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_633912_2 399739.Pmen_2883 2.85e-70 220.0 COG3627@1|root,COG3627@2|Bacteria,1MV7T@1224|Proteobacteria,1RNI7@1236|Gammaproteobacteria,1YE4K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose phnJ GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016829,GO:0018835,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0098848,GO:1901575,GO:1902494,GO:1904176 4.7.1.1 ko:K06163 ko00440,map00440 - R10204 RC03078,RC03079 ko00000,ko00001,ko01000 - - - PhnJ k59_1141118_2 535289.Dtpsy_1751 7.79e-61 203.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,4AA63@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - DAO,ETF_QO,FAD_binding_2,NAD_binding_8 k59_1141120_1 1124780.ANNU01000013_gene3849 3.77e-113 347.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,47MI5@768503|Cytophagia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_602675_1 614083.AWQR01000054_gene1946 8.11e-44 152.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,4AAFQ@80864|Comamonadaceae 28216|Betaproteobacteria S hydrolase of the alpha - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_602675_2 1123504.JQKD01000003_gene502 1.58e-24 96.3 COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,4AE1B@80864|Comamonadaceae 28216|Betaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_713317_2 519989.ECTPHS_13748 5.14e-21 99.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin PilY1 pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_959595_1 1225184.ALXE01000028_gene1730 1.16e-33 121.0 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,3W0PP@53335|Pantoea 1236|Gammaproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_713354_1 614083.AWQR01000013_gene1687 2.04e-64 218.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_713384_1 1122605.KB893644_gene1412 5.95e-26 104.0 COG1005@1|root,COG1005@2|Bacteria,4NGK7@976|Bacteroidetes,1IR49@117747|Sphingobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_713384_2 1123248.KB893314_gene3395 1.03e-38 140.0 COG1034@1|root,COG1034@2|Bacteria,4NH3P@976|Bacteroidetes,1IR1J@117747|Sphingobacteriia 976|Bacteroidetes C PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,NADH-G_4Fe-4S_3 k59_634114_1 614083.AWQR01000011_gene2351 7.96e-73 228.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,4AAMW@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA selU - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_927476_1 420662.Mpe_A1289 6.4e-44 158.0 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,1KK79@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_713462_1 700598.Niako_2188 6.83e-89 283.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,1IW7P@117747|Sphingobacteriia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_245868_1 483219.LILAB_02625 1.34e-26 107.0 COG2162@1|root,COG2162@2|Bacteria,1RDF3@1224|Proteobacteria,42UY1@68525|delta/epsilon subdivisions,2WSDJ@28221|Deltaproteobacteria,2YVZI@29|Myxococcales 28221|Deltaproteobacteria Q Belongs to the arylamine N-acetyltransferase family - - 2.3.1.118 ko:K00675 - - - - ko00000,ko01000 - - - Acetyltransf_2 k59_998821_1 338969.Rfer_3758 1.12e-26 99.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2VVV9@28216|Betaproteobacteria,4AFPU@80864|Comamonadaceae 28216|Betaproteobacteria P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_998821_2 338969.Rfer_3757 4.11e-46 150.0 COG1937@1|root,COG1937@2|Bacteria,1NIAR@1224|Proteobacteria,2VY57@28216|Betaproteobacteria,4AJT8@80864|Comamonadaceae 28216|Betaproteobacteria S Metal-sensitive transcriptional repressor - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_927521_1 296591.Bpro_4705 7.25e-12 61.6 COG2963@1|root,COG2963@2|Bacteria,1N335@1224|Proteobacteria,2VWZJ@28216|Betaproteobacteria,4AIBT@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase IS3 IS911 family protein - - - - - - - - - - - - HTH_Tnp_1 k59_927521_2 202956.BBNL01000003_gene1285 0.000971 44.3 COG0790@1|root,COG0790@2|Bacteria,1NMS9@1224|Proteobacteria,1SJF3@1236|Gammaproteobacteria,3NIFB@468|Moraxellaceae 1236|Gammaproteobacteria S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_959791_1 1144275.COCOR_02594 2.58e-44 164.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - ko:K16416 ko01052,map01052 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_713534_2 1266925.JHVX01000007_gene2298 1.5e-29 127.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria,372E2@32003|Nitrosomonadales 28216|Betaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_998910_2 1172181.KB911721_gene3866 5.51e-27 112.0 COG1132@1|root,COG1132@2|Bacteria,2GJWP@201174|Actinobacteria 201174|Actinobacteria V ABC transporter ywjA - - ko:K06147,ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_782714_2 526222.Desal_2411 6.62e-05 47.4 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MBFU@213115|Desulfovibrionales 28221|Deltaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1141399_1 1157708.KB907455_gene3326 1.2e-13 67.0 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,4ADXS@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ - - - - - - - - - - - NUDIX k59_1141399_2 535289.Dtpsy_3303 6.91e-119 350.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4A9YY@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_927654_1 84531.JMTZ01000002_gene793 1.56e-77 242.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1X81C@135614|Xanthomonadales 135614|Xanthomonadales K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_999015_1 614083.AWQR01000009_gene513 1.65e-126 362.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,4AAGU@80864|Comamonadaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_246041_1 358220.C380_12675 2.51e-48 166.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VJI2@28216|Betaproteobacteria,4AAGM@80864|Comamonadaceae 28216|Betaproteobacteria EJ PFAM Asparaginase glutaminase ansB - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_427063_1 1274374.CBLK010000067_gene1501 7.61e-06 48.9 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,4HADG@91061|Bacilli,26QF4@186822|Paenibacillaceae 91061|Bacilli HP Part of the FecBCDE citrate-dependent iron (III) transport system fecE - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_427063_2 640081.Dsui_1466 4.7e-55 183.0 COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2VNEP@28216|Betaproteobacteria,2KXVX@206389|Rhodocyclales 206389|Rhodocyclales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_782803_1 1485544.JQKP01000001_gene1326 2.29e-17 77.8 2D2K4@1|root,32TD0@2|Bacteria,1MZKF@1224|Proteobacteria,2VUUX@28216|Betaproteobacteria,44WIR@713636|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF3124) - - - - - - - - - - - - DUF3124 k59_782803_2 159087.Daro_0106 1.21e-10 61.6 COG2208@1|root,COG3829@1|root,COG2208@2|Bacteria,COG3829@2|Bacteria,1N4K5@1224|Proteobacteria,2VKGP@28216|Betaproteobacteria,2KVU6@206389|Rhodocyclales 206389|Rhodocyclales T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - PAS_4,SpoIIE k59_927741_1 1266998.ATUJ01000011_gene2462 2.13e-18 83.6 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2PYQZ@265|Paracoccus 28211|Alphaproteobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_603151_1 935863.AWZR01000009_gene25 1.04e-14 73.2 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1X4SH@135614|Xanthomonadales 135614|Xanthomonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_603151_2 1122951.ATUE01000008_gene68 7.06e-42 149.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,3NJGF@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_782871_1 1267211.KI669560_gene543 5.88e-76 233.0 COG1212@1|root,COG1212@2|Bacteria,4NG4B@976|Bacteroidetes,1IXQH@117747|Sphingobacteriia 976|Bacteroidetes M Cytidylyltransferase kdsB - 1.1.3.48,2.7.7.38 ko:K00979,ko:K19714 ko00540,ko01100,map00540,map01100 M00063 R03351,R11394,R11396 RC00152,RC00910,RC03427 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_246121_1 696747.NIES39_Q02380 9.73e-12 65.9 COG0438@1|root,COG0438@2|Bacteria,1G4Q4@1117|Cyanobacteria,1H84U@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glycos_transf_1 k59_999132_2 29581.BW37_01330 4.45e-49 168.0 COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,473MI@75682|Oxalobacteraceae 28216|Betaproteobacteria C Catalase katA2 - 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase,Catalase-rel k59_999167_1 1035193.HMPREF9073_01000 1.3e-08 59.3 COG4848@1|root,COG4848@2|Bacteria,4NRV5@976|Bacteroidetes,1I36V@117743|Flavobacteriia,1EQTP@1016|Capnocytophaga 976|Bacteroidetes S Protein of unknown function (DUF1444) - - - - - - - - - - - - DUF1444 k59_999167_2 1349767.GJA_1860 8.08e-34 122.0 COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2VQ6E@28216|Betaproteobacteria,476NV@75682|Oxalobacteraceae 28216|Betaproteobacteria S hydrolases of HD superfamily - - - ko:K06952 - - - - ko00000 - - - - k59_927832_1 358220.C380_18555 1.56e-26 107.0 COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2VHXT@28216|Betaproteobacteria,4A9YQ@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_927832_2 358220.C380_00185 7.32e-38 132.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,4AEP7@80864|Comamonadaceae 28216|Betaproteobacteria S NnrU protein nnrU - - - - - - - - - - - NnrU k59_960122_1 1316927.ATKI01000032_gene4867 3.43e-05 50.8 COG0689@1|root,COG2931@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1YSF7@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Pectate lyase superfamily protein psmE - - - - - - - - - - - Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C k59_960125_1 859657.RPSI07_mp1392 7.68e-08 54.3 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,2VJ1T@28216|Betaproteobacteria,1KH3B@119060|Burkholderiaceae 28216|Betaproteobacteria NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_960125_2 399795.CtesDRAFT_PD4618 2.75e-49 166.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,4ABGR@80864|Comamonadaceae 28216|Betaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_754217_1 1437824.BN940_06461 7.16e-64 207.0 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2W9MD@28216|Betaproteobacteria,3T7GM@506|Alcaligenaceae 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_827006_1 640081.Dsui_2814 4.98e-96 299.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1041398_1 1000565.METUNv1_01517 2.73e-80 254.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUHI@206389|Rhodocyclales 206389|Rhodocyclales G PQQ-like domain - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_540291_1 338969.Rfer_0729 2.38e-100 303.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,4AAC1@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_329652_2 614083.AWQR01000006_gene344 1.98e-47 159.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,4AB7N@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase SDR - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 ko:K00059,ko:K03793 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_41888_4 1460640.JCM19046_3542 1.59e-17 79.7 2EGZP@1|root,33ART@2|Bacteria,1VKPB@1239|Firmicutes,4HR69@91061|Bacilli 91061|Bacilli S YopX protein - - - - - - - - - - - - YopX k59_41888_5 314345.SPV1_03053 1.23e-12 70.9 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria 1224|Proteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - LysM,PG_binding_1,Peptidase_C39_2,SLT k59_363136_1 1123487.KB892834_gene2592 1.09e-06 49.3 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,2KUD6@206389|Rhodocyclales 206389|Rhodocyclales M epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_329667_1 1000565.METUNv1_02458 2.83e-73 221.0 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,2VVSJ@28216|Betaproteobacteria,2KX9R@206389|Rhodocyclales 206389|Rhodocyclales NU Pilin (bacterial filament) - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_329667_2 1000565.METUNv1_02459 1.23e-19 91.7 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,2VX93@28216|Betaproteobacteria,2KXPI@206389|Rhodocyclales 206389|Rhodocyclales S TPR repeat - - - - - - - - - - - - TPR_16,TPR_8 k59_754234_1 335543.Sfum_0996 7.87e-55 179.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MQ9Z@213462|Syntrophobacterales 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_1111099_1 887062.HGR_14874 3.81e-72 227.0 COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,2VID4@28216|Betaproteobacteria,4ABHI@80864|Comamonadaceae 28216|Betaproteobacteria E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_438709_2 365044.Pnap_2323 2.51e-48 156.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,2VR48@28216|Betaproteobacteria 28216|Betaproteobacteria S Nitrogen fixation protein NifX nifX - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_78493_1 1348657.M622_15090 3.36e-56 184.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,2KV5Z@206389|Rhodocyclales 206389|Rhodocyclales JM Nucleotidyl transferase - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_78493_2 1000565.METUNv1_03865 1.48e-220 624.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,2KW5F@206389|Rhodocyclales 206389|Rhodocyclales T Two-component sensor kinase N-terminal - - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_720313_1 1504672.669785653 2.29e-79 249.0 COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,2VJ4B@28216|Betaproteobacteria,4AJZ2@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Phosphate acetyl butaryl transferase - - 2.3.1.19,2.3.1.8 ko:K00625,ko:K00634 ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921,R01174 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas,PTA_PTB k59_42816_1 83406.HDN1F_32470 5.62e-104 310.0 COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria 1236|Gammaproteobacteria I hydroxymethylglutaryl-CoA reductase - - 1.1.1.34 ko:K00021 ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976 M00095 R02082 RC00004,RC00644 ko00000,ko00001,ko00002,ko01000 - - - HMG-CoA_red k59_653022_1 649638.Trad_2857 2.63e-37 139.0 COG1216@1|root,COG1216@2|Bacteria,1WK51@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1111840_1 1000565.METUNv1_00621 3.34e-45 146.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,2KWX1@206389|Rhodocyclales 206389|Rhodocyclales IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_1111840_2 1000565.METUNv1_00620 9.52e-125 361.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,2KUFK@206389|Rhodocyclales 206389|Rhodocyclales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1042254_1 62928.azo1190 2.74e-16 77.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,2KU6M@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the radical SAM superfamily. PqqE family pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_14,Radical_SAM,SPASM k59_1042254_2 62928.azo1189 3.26e-31 112.0 2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,2VVSC@28216|Betaproteobacteria,2KZ90@206389|Rhodocyclales 206389|Rhodocyclales S Coenzyme PQQ synthesis protein D (PqqD) pqqD - - ko:K06138 - - - - ko00000 - - - PqqD k59_78506_1 159087.Daro_3716 8.38e-27 106.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,2VNGX@28216|Betaproteobacteria,2KUD0@206389|Rhodocyclales 206389|Rhodocyclales D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_78506_2 640081.Dsui_1023 7.65e-44 148.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2VINI@28216|Betaproteobacteria,2KVKB@206389|Rhodocyclales 206389|Rhodocyclales D cell division ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_933403_1 1107311.Q767_13410 1.39e-89 271.0 COG0730@1|root,COG0730@2|Bacteria,4NKPI@976|Bacteroidetes,1HX5U@117743|Flavobacteriia,2NUIJ@237|Flavobacterium 976|Bacteroidetes S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_899907_1 661367.LLO_2647 1.82e-98 304.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1JD9B@118969|Legionellales 118969|Legionellales U STAS domain dauA_1 - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_899907_2 272560.BPSS1152 1.02e-06 47.4 COG3905@1|root,COG3905@2|Bacteria,1N7D2@1224|Proteobacteria,2VW4A@28216|Betaproteobacteria,1KA7F@119060|Burkholderiaceae 28216|Betaproteobacteria K copG family - - - - - - - - - - - - RHH_1 k59_257070_1 1000565.METUNv1_02639 1.12e-16 75.1 COG2747@1|root,COG2747@2|Bacteria,1NGJA@1224|Proteobacteria,2VWP5@28216|Betaproteobacteria,2KXGB@206389|Rhodocyclales 206389|Rhodocyclales N negative regulator of flagellin synthesis - - - ko:K02398 ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlgM k59_438749_1 1504672.669787286 2.07e-129 378.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VJIT@28216|Betaproteobacteria,4AC6D@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22,2.6.1.76 ko:K00823,ko:K00836,ko:K07250 ko00250,ko00260,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00280,map00410,map00640,map00650,map01100,map01120,map01210,map01230 M00027,M00033 R00908,R01648,R04188,R06977 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_969249_1 1000565.METUNv1_00694 2.83e-136 394.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,2KU6U@206389|Rhodocyclales 206389|Rhodocyclales P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_541068_1 640081.Dsui_1705 1.25e-83 256.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2VHMJ@28216|Betaproteobacteria,2KV8A@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_541068_2 1123487.KB892836_gene3263 2.57e-25 101.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VHPX@28216|Betaproteobacteria,2KU78@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_933414_1 694427.Palpr_0074 8.07e-138 408.0 COG3534@1|root,COG3534@2|Bacteria,4NGMQ@976|Bacteroidetes,2FN4W@200643|Bacteroidia,22WMU@171551|Porphyromonadaceae 976|Bacteroidetes G Alpha-L-arabinofuranosidase C-terminus - - - - - - - - - - - - Alpha-L-AF_C,CBM_4_9 k59_113071_1 29581.BW37_05108 7.29e-83 266.0 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2VJ6I@28216|Betaproteobacteria,473AD@75682|Oxalobacteraceae 28216|Betaproteobacteria M Protein involved in outer membrane biogenesis asmA - - ko:K07289,ko:K07290 - - - - ko00000 9.B.121 - - AsmA k59_257088_1 1121438.JNJA01000009_gene4075 5.32e-27 104.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,42RE5@68525|delta/epsilon subdivisions,2WNNI@28221|Deltaproteobacteria,2MC6M@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM SEC-C motif - - - ko:K09858 - - - - ko00000 - - - SEC-C k59_257088_2 1353529.M899_2351 3.51e-22 96.3 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,42NY6@68525|delta/epsilon subdivisions,2MSSY@213481|Bdellovibrionales,2WJSE@28221|Deltaproteobacteria 213481|Bdellovibrionales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1081457_1 1000565.METUNv1_02487 7.1e-146 414.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_470949_1 1121935.AQXX01000124_gene127 8.97e-32 127.0 COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria,1XIW7@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome c - - - - - - - - - - - - - k59_611097_1 329726.AM1_2608 1.13e-19 86.3 COG0625@1|root,COG0625@2|Bacteria,1G5VJ@1117|Cyanobacteria 1117|Cyanobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_6,GST_N_4 k59_438794_1 543728.Vapar_3067 3.16e-22 99.0 COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,2VIB0@28216|Betaproteobacteria 28216|Betaproteobacteria C formylmethanofuran dehydrogenase fhcB - 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - - k59_438794_2 1000565.METUNv1_01448 5.6e-163 463.0 COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,2VMEM@28216|Betaproteobacteria,2KWG0@206389|Rhodocyclales 206389|Rhodocyclales S GHMP kinases C terminal - - - - - - - - - - - - GHMP_kinases_C k59_331362_2 1266908.AQPB01000051_gene2464 2.4e-09 59.7 2E13U@1|root,32WJ6@2|Bacteria,1NFFY@1224|Proteobacteria,1SIE5@1236|Gammaproteobacteria,1X1KW@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_862310_1 1211777.BN77_4169 1.17e-131 390.0 2C5GI@1|root,2Z8C1@2|Bacteria,1R8XM@1224|Proteobacteria,2TUME@28211|Alphaproteobacteria,4BJKS@82115|Rhizobiaceae 28211|Alphaproteobacteria S P22 coat protein - gene protein 5 - - - - - - - - - - - - P22_CoatProtein k59_510052_1 1000565.METUNv1_03778 1.15e-107 327.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KYI9@206389|Rhodocyclales 206389|Rhodocyclales M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_510052_2 748247.AZKH_3609 4.62e-74 240.0 2F1MY@1|root,33UN8@2|Bacteria,1NUMN@1224|Proteobacteria,2W1XE@28216|Betaproteobacteria,2KYNC@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_510052_3 1000565.METUNv1_03780 1.59e-21 97.1 COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria,2WEH7@28216|Betaproteobacteria,2KY9X@206389|Rhodocyclales 206389|Rhodocyclales S Heparinase II/III-like protein - - - - - - - - - - - - DUF4962,Hepar_II_III,VanZ k59_400188_1 700598.Niako_5588 5.25e-54 182.0 COG0861@1|root,COG0861@2|Bacteria,4NH6F@976|Bacteroidetes,1J0BP@117747|Sphingobacteriia 976|Bacteroidetes P Integral membrane protein TerC family - - - - - - - - - - - - TerC k59_683649_1 1121035.AUCH01000016_gene2154 5.21e-94 288.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,2KV14@206389|Rhodocyclales 206389|Rhodocyclales M Membrane-bound lytic murein transglycosylase mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_113114_1 696747.NIES39_O06480 8.06e-36 136.0 COG2081@1|root,COG2081@2|Bacteria,1FZZ1@1117|Cyanobacteria,1H7GT@1150|Oscillatoriales 1117|Cyanobacteria S PFAM HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_438849_1 1000565.METUNv1_00115 5.3e-105 336.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales 206389|Rhodocyclales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_42899_1 1268068.PG5_28380 3.99e-77 248.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,1RNRM@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_611131_1 756883.Halar_0554 5.24e-17 85.5 COG4983@1|root,arCOG06276@2157|Archaea 2157|Archaea L peptidase activity - - - ko:K06919 - - - - ko00000 - - - - k59_1081552_1 59538.XP_005966719.1 9.11e-18 82.0 COG0740@1|root,KOG0840@2759|Eukaryota,38PE0@33154|Opisthokonta,3BEPT@33208|Metazoa,3CVZ0@33213|Bilateria,47ZUG@7711|Chordata,49730@7742|Vertebrata,3J8SI@40674|Mammalia,4J01K@91561|Cetartiodactyla 33208|Metazoa O ATP-dependent Clp protease proteolytic subunit - - - - - - - - - - - - CLP_protease k59_1081552_2 397945.Aave_1458 5.52e-48 164.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,4A9Q7@80864|Comamonadaceae 28216|Betaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_400210_1 640081.Dsui_1947 8.8e-136 395.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,2KUMY@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_510120_1 448385.sce8955 1.01e-33 129.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,42R7N@68525|delta/epsilon subdivisions,2WSTT@28221|Deltaproteobacteria,2Z27Z@29|Myxococcales 28221|Deltaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_257157_1 1218075.BAYA01000055_gene6938 2.48e-08 53.9 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,2VJFQ@28216|Betaproteobacteria,1K497@119060|Burkholderiaceae 28216|Betaproteobacteria S KR domain - - - ko:K07124 - - - - ko00000 - - - adh_short k59_364356_1 1100720.ALKN01000014_gene1813 6.88e-18 79.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,4A9QS@80864|Comamonadaceae 28216|Betaproteobacteria L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_364356_2 1276756.AUEX01000009_gene1800 2.77e-17 83.2 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4AA2F@80864|Comamonadaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family rhlE1 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - - - - - - - - - - DEAD,Helicase_C k59_331441_1 1000565.METUNv1_02733 2.07e-20 87.8 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,2KV89@206389|Rhodocyclales 206389|Rhodocyclales M pfkB family carbohydrate kinase - - 2.7.1.167 ko:K21344 ko00540,map00540 M00064 R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_331441_2 1000565.METUNv1_02732 2.78e-121 355.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales 206389|Rhodocyclales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16 k59_510128_2 1287276.X752_26160 7.48e-08 55.8 2D78S@1|root,32TNJ@2|Bacteria,1N0VB@1224|Proteobacteria,2UCAT@28211|Alphaproteobacteria,43KRP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4864) - - - - - - - - - - - - DUF4864 k59_42925_1 1357272.AVEO02000021_gene3356 3.19e-76 242.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Z6P2@136849|Pseudomonas syringae group 1236|Gammaproteobacteria T fimbriae expression regulatory protein pilR pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_611153_1 1454004.AW11_00504 8.71e-99 301.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VHEY@28216|Betaproteobacteria,1KR6Z@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor gabR_2 - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_1111927_1 1005048.CFU_1484 4.61e-12 64.7 COG0454@1|root,COG0456@2|Bacteria,1RIU4@1224|Proteobacteria,2W38U@28216|Betaproteobacteria 28216|Betaproteobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_828536_1 1492738.FEM21_20930 2.02e-74 237.0 COG4225@1|root,COG4225@2|Bacteria,4NH7G@976|Bacteroidetes,1HZNV@117743|Flavobacteriia,2NTHA@237|Flavobacterium 976|Bacteroidetes S Glycosyl Hydrolase Family 88 yteR_9 - - - - - - - - - - - Glyco_hydro_88,Lipase_GDSL_2 k59_148623_1 614083.AWQR01000018_gene1920 1.87e-56 183.0 COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,2VRH7@28216|Betaproteobacteria,4AG9U@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) thiM - 2.7.1.50 ko:K00878 ko00730,ko01100,map00730,map01100 M00127 R04448 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HK k59_42934_1 1504672.669785919 2.31e-28 114.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,4AA7Z@80864|Comamonadaceae 28216|Betaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_42934_2 1504672.669785920 9.93e-22 90.9 28IWK@1|root,2Z8UV@2|Bacteria,1P9EC@1224|Proteobacteria,2VJZY@28216|Betaproteobacteria,4A9V5@80864|Comamonadaceae 28216|Betaproteobacteria S Type II secretion system (T2SS), protein N gspN - - ko:K02463 ko05111,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSN k59_471027_1 358220.C380_13925 4.17e-80 266.0 COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,2VPE3@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_792554_1 1286631.X805_26730 3.45e-38 140.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1KJTE@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Aminotransferase class-V - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_792554_2 1116472.MGMO_18c00100 4.73e-23 92.4 2D4GA@1|root,32TH1@2|Bacteria,1N4D6@1224|Proteobacteria,1TI4M@1236|Gammaproteobacteria,1XGHI@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF3024) - - - - - - - - - - - - DUF3024 k59_828544_1 1000565.METUNv1_03923 0.0 947.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KUQF@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - - k59_438934_2 1401067.HMPREF0872_00075 9.33e-15 73.6 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H298@909932|Negativicutes 909932|Negativicutes C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_471033_1 1485544.JQKP01000003_gene285 4.23e-79 248.0 COG0738@1|root,COG0738@2|Bacteria,1MXDC@1224|Proteobacteria,2VN8R@28216|Betaproteobacteria 28216|Betaproteobacteria G glucose galactose transporter gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_1081607_2 1485544.JQKP01000002_gene1453 1.51e-49 175.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,44V3Z@713636|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_763910_1 1434929.X946_4597 1.77e-54 180.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,1K14B@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1054853_1 1082932.ATCR1_15791 1.41e-111 335.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,4B9HX@82115|Rhizobiaceae 28211|Alphaproteobacteria I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) mccB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1092186_1 1000565.METUNv1_00467 7.13e-64 199.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,2KVGG@206389|Rhodocyclales 206389|Rhodocyclales S synthesis repressor, PhaR - - - - - - - - - - - - PHB_acc,PHB_acc_N k59_1092194_2 925409.KI911562_gene2351 1.37e-26 110.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IPE6@117747|Sphingobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1016670_1 232721.Ajs_1658 4.7e-60 194.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,4AADA@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_53232_1 1304885.AUEY01000004_gene1007 5.23e-12 70.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_348355_2 1121033.AUCF01000003_gene3478 1.01e-10 60.5 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2JPN3@204441|Rhodospirillales 204441|Rhodospirillales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_873685_1 748247.AZKH_0193 7.43e-57 202.0 COG0784@1|root,COG2197@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2197@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,2KZWN@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_53242_1 1442599.JAAN01000052_gene2652 1.82e-22 99.4 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,1RP3U@1236|Gammaproteobacteria,1X5KU@135614|Xanthomonadales 135614|Xanthomonadales L Recombinase - - - - - - - - - - - - Recombinase,Resolvase k59_873689_2 289376.THEYE_A1436 2.47e-26 101.0 COG0093@1|root,COG0093@2|Bacteria,3J0JD@40117|Nitrospirae 40117|Nitrospirae J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_620147_2 1268622.AVS7_01975 4.58e-59 191.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,4ACSW@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Enoyl-CoA hydratase isomerase fadB3 - - - - - - - - - - - ECH_1 k59_125221_2 643867.Ftrac_1603 1.28e-40 137.0 COG4323@1|root,COG4323@2|Bacteria,4NSJX@976|Bacteroidetes,47VCT@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF962) - - - - - - - - - - - - DUF962 k59_228667_1 570952.ATVH01000013_gene3036 1.34e-62 199.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,2JR2U@204441|Rhodospirillales 204441|Rhodospirillales P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_410016_1 1245469.S58_27390 8.18e-58 190.0 COG0346@1|root,COG0346@2|Bacteria,1MVVU@1224|Proteobacteria,2U08H@28211|Alphaproteobacteria,3JVAE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyoxalase k59_529510_1 1123256.KB907926_gene848 1.37e-13 70.1 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1X3P0@135614|Xanthomonadales 135614|Xanthomonadales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_529510_2 640081.Dsui_1995 1.88e-22 99.4 COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2VKGI@28216|Betaproteobacteria,2KW58@206389|Rhodocyclales 206389|Rhodocyclales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_18300_1 700598.Niako_1941 5.97e-92 289.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,1IP6D@117747|Sphingobacteriia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_840098_1 926550.CLDAP_36430 3.53e-26 105.0 COG1175@1|root,COG1175@2|Bacteria,2G6P7@200795|Chloroflexi 200795|Chloroflexi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K05814 ko02010,map02010 M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 - - BPD_transp_1 k59_840098_2 525904.Tter_0427 9.89e-05 45.1 COG1653@1|root,COG1653@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 k59_1093083_1 382464.ABSI01000012_gene2223 4.55e-26 112.0 COG5002@1|root,COG5002@2|Bacteria,46Z3U@74201|Verrucomicrobia,2IWP7@203494|Verrucomicrobiae 203494|Verrucomicrobiae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_54678_1 1286093.C266_06981 2.51e-21 92.8 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,1K0PG@119060|Burkholderiaceae 28216|Betaproteobacteria S Extradiol ring-cleavage dioxygenase class III protein subunit B ygiD - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_377450_1 1538295.JY96_07785 3.5e-65 228.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VHH4@28216|Betaproteobacteria,1KPFU@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Filamentous haemagglutinin family outer membrane protein - - - - - - - - - - - - DUF3739,ESPR,Haemagg_act k59_269819_1 1347392.CCEZ01000049_gene1387 2.73e-10 64.3 COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,36DKK@31979|Clostridiaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_672771_1 1000565.METUNv1_03780 5.06e-90 292.0 COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria,2WEH7@28216|Betaproteobacteria,2KY9X@206389|Rhodocyclales 206389|Rhodocyclales S Heparinase II/III-like protein - - - - - - - - - - - - DUF4962,Hepar_II_III,VanZ k59_307253_1 987059.RBXJA2T_00100 2.31e-74 233.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,1KJP4@119065|unclassified Burkholderiales 28216|Betaproteobacteria K RNA polymerase sigma factor RpoH rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_529576_2 983917.RGE_04280 3.26e-18 83.6 COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,2VTMV@28216|Betaproteobacteria,1KNC3@119065|unclassified Burkholderiales 28216|Betaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_529577_1 358220.C380_11120 6.95e-27 105.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2VRTK@28216|Betaproteobacteria,4ACHD@80864|Comamonadaceae 28216|Betaproteobacteria D Belongs to the ParA family fleN - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA k59_529577_2 397945.Aave_2572 1.55e-38 139.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,4ABW5@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM isocitrate dehydrogenase, NADP-dependent icd GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_269840_1 1538295.JY96_18305 4.98e-107 321.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2VHMG@28216|Betaproteobacteria,1KK8E@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nitrogenase molybdenum-iron protein, alpha nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_483667_1 204773.HEAR3308 2.34e-22 95.5 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,473JH@75682|Oxalobacteraceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_483667_2 1069080.KB913028_gene1545 7.77e-22 96.7 COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,1UCKT@1239|Firmicutes,4H2Z5@909932|Negativicutes 909932|Negativicutes T PFAM ATP-binding region ATPase domain protein, ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind,HATPase_c k59_765119_1 1267211.KI669560_gene1686 1.79e-64 203.0 COG0705@1|root,COG0705@2|Bacteria,4NECA@976|Bacteroidetes,1IS27@117747|Sphingobacteriia 976|Bacteroidetes S Rhomboid family - - - - - - - - - - - - Rhomboid k59_1018204_1 2002.JOEQ01000032_gene1789 5.89e-05 43.5 COG2963@1|root,COG2963@2|Bacteria,2IM4Y@201174|Actinobacteria,4EPTR@85012|Streptosporangiales 201174|Actinobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1018204_2 1150626.PHAMO_370014 1.54e-64 205.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,2JZN8@204441|Rhodospirillales 204441|Rhodospirillales L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_980544_1 395495.Lcho_2148 5.77e-93 284.0 COG1055@1|root,COG1055@2|Bacteria,1N68M@1224|Proteobacteria,2VH3A@28216|Betaproteobacteria,1KIYU@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Putative Na+/H+ antiporter - - - - - - - - - - - - Na_H_antiport_3 k59_377484_1 595537.Varpa_3693 4.04e-63 206.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,4A9WQ@80864|Comamonadaceae 28216|Betaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_731687_1 1000565.METUNv1_02702 4.18e-168 499.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVA4@206389|Rhodocyclales 206389|Rhodocyclales U efflux pump - - - ko:K18138,ko:K18146 ko01501,ko01503,map01501,map01503 M00647,M00649,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.40 - - ACR_tran k59_307286_1 903818.KI912268_gene861 3.58e-67 216.0 COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria 57723|Acidobacteria E aromatic amino acid beta-eliminating lyase threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_350824_1 1122951.ATUE01000005_gene1542 1.59e-109 322.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,3NIWP@468|Moraxellaceae 1236|Gammaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665 Pribosyl_synth,Pribosyltran_N k59_875277_1 338969.Rfer_3482 2.57e-06 48.5 COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,2VQMP@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM Tripartite ATP-independent periplasmic transporter, DctQ component dctQ - - ko:K11689 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ k59_875277_2 640081.Dsui_3155 3.58e-99 296.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,2KV1X@206389|Rhodocyclales 206389|Rhodocyclales G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_307292_1 1100720.ALKN01000018_gene1775 1.96e-33 120.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,4AAZY@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_307292_2 338969.Rfer_0748 5.49e-24 100.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,4AA54@80864|Comamonadaceae 28216|Betaproteobacteria CO PFAM cytochrome c biogenesis protein, transmembrane region - - 1.8.1.8 ko:K04084,ko:K08344 - - - - ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.5 - - DsbC,DsbD,Thioredoxin_7 k59_269873_1 159087.Daro_3975 2.78e-92 285.0 COG2199@1|root,COG3614@1|root,COG2199@2|Bacteria,COG3614@2|Bacteria,1RGCV@1224|Proteobacteria,2WGZP@28216|Betaproteobacteria,2KVQG@206389|Rhodocyclales 206389|Rhodocyclales T CHASE - - - - - - - - - - - - CHASE,GGDEF,PAS_3 k59_529659_1 397945.Aave_4704 8.56e-47 168.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJD4@28216|Betaproteobacteria,4AD48@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_695205_1 1000565.METUNv1_03778 8.81e-117 348.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KYI9@206389|Rhodocyclales 206389|Rhodocyclales M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_125348_1 1267211.KI669560_gene97 8.39e-47 155.0 COG3034@1|root,COG3034@2|Bacteria,4NU5W@976|Bacteroidetes,1J0EF@117747|Sphingobacteriia 976|Bacteroidetes M L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_840224_1 232721.Ajs_0473 1.22e-112 330.0 COG0664@1|root,COG0664@2|Bacteria,1MUHT@1224|Proteobacteria,2VI43@28216|Betaproteobacteria,4ACD6@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, Crp Fnr family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_350911_1 296591.Bpro_1063 7.4e-28 108.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,4ABM6@80864|Comamonadaceae 28216|Betaproteobacteria S Cobalamin synthesis protein P47K yjiA_1 - - - - - - - - - - - CobW_C,cobW k59_1057218_1 1163617.SCD_n01652 1.81e-81 264.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria 28216|Betaproteobacteria O TPR repeat-containing protein - - - - - - - - - - - - Glyco_tranf_2_5,Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 k59_161478_1 1168034.FH5T_06745 4.12e-78 251.0 COG2244@1|root,COG2244@2|Bacteria,4NPGZ@976|Bacteroidetes,2G3BA@200643|Bacteroidia 976|Bacteroidetes S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_980601_1 159087.Daro_1871 9.66e-22 97.8 COG1835@1|root,COG1835@2|Bacteria,1RG3B@1224|Proteobacteria,2VSQ6@28216|Betaproteobacteria 28216|Betaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_125359_1 522306.CAP2UW1_0246 1.27e-55 184.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,1KQFA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_125359_2 543913.D521_1042 1.34e-21 93.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KQCV@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_805338_1 864073.HFRIS_014634 1.65e-39 140.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,47247@75682|Oxalobacteraceae 28216|Betaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_54791_1 1122197.ATWI01000015_gene815 4.17e-19 91.3 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,464KE@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF domain - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_1122708_1 1122605.KB893636_gene3465 1.46e-73 238.0 COG0173@1|root,COG0173@2|Bacteria,4NECY@976|Bacteroidetes,1IR7B@117747|Sphingobacteriia 976|Bacteroidetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_529765_1 640081.Dsui_3060 2.44e-28 107.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2VIU9@28216|Betaproteobacteria,2KW2K@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_529765_2 640081.Dsui_3061 2.57e-38 130.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,2VVP0@28216|Betaproteobacteria,2KXBI@206389|Rhodocyclales 206389|Rhodocyclales J RNA-binding protein containing KH domain possibly ribosomal protein - - - - - - - - - - - - CRS1_YhbY k59_673006_1 1454004.AW11_03844 1.05e-13 69.7 COG1483@1|root,COG1483@2|Bacteria,1MX1G@1224|Proteobacteria,2VHB3@28216|Betaproteobacteria,1KQ8Z@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF499) - - - ko:K06922 - - - - ko00000 - - - DUF499 k59_483831_1 1198452.Jab_1c05850 8.2e-103 308.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,472DR@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_553845_1 748247.AZKH_1710 2.11e-84 256.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,2KUMP@206389|Rhodocyclales 206389|Rhodocyclales S COG0714 MoxR-like ATPases norQ - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_553845_2 497321.C664_06758 9.77e-23 95.1 COG0348@1|root,COG0348@2|Bacteria,1MUWD@1224|Proteobacteria,2VMUP@28216|Betaproteobacteria,2KUX9@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 k59_1057325_1 338969.Rfer_1340 5.85e-18 82.4 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,4AAPP@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_628691_1 1070319.CAGGBEG34_210019 1.08e-59 204.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,1K3H7@119060|Burkholderiaceae 28216|Betaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_420834_1 1000565.METUNv1_03417 4.42e-35 140.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_29729_1 614083.AWQR01000031_gene2621 3.7e-86 268.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,4A9RZ@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_953235_2 196367.JNFG01000034_gene7546 2.19e-65 202.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,1JZUB@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_815711_1 365046.Rta_04090 9.32e-85 269.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,4AAKB@80864|Comamonadaceae 28216|Betaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_66039_1 640081.Dsui_1220 5.3e-98 296.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,2KUNP@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_628715_1 1000565.METUNv1_03771 8.2e-92 276.0 COG4424@1|root,COG4424@2|Bacteria,1QVF4@1224|Proteobacteria,2VMVK@28216|Betaproteobacteria,2KY2S@206389|Rhodocyclales 206389|Rhodocyclales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_281864_1 398525.KB900701_gene6260 9.13e-07 53.1 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,3JZQV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_953268_1 1122951.ATUE01000005_gene1833 1.43e-147 427.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,3NJHZ@468|Moraxellaceae 1236|Gammaproteobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_173771_1 1123248.KB893348_gene307 4.89e-43 145.0 COG3124@1|root,COG3124@2|Bacteria,4NHQK@976|Bacteroidetes,1IZCY@117747|Sphingobacteriia 976|Bacteroidetes S Acyl carrier protein phosphodiesterase acpH - - - - - - - - - - - ACP_PD k59_889586_1 589865.DaAHT2_0454 2.98e-18 83.6 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2MID1@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM PhoH family protein phoH2 - - ko:K06217 - - - - ko00000 - - - PhoH k59_889586_2 471854.Dfer_3801 1.08e-16 79.7 COG0319@1|root,COG0319@2|Bacteria,4NS93@976|Bacteroidetes,47Q9Q@768503|Cytophagia 976|Bacteroidetes S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - - - - - - - - - - UPF0054 k59_854157_1 614083.AWQR01000018_gene1926 1.76e-93 280.0 COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2VMHF@28216|Betaproteobacteria,4AABV@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aromatic amino acid phhA GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016714,GO:0055114 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H k59_743612_1 1458427.BAWN01000059_gene2185 1.91e-20 92.4 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AAD0@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_743612_2 1123504.JQKD01000035_gene2644 3.83e-34 122.0 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,4A9RP@80864|Comamonadaceae 28216|Betaproteobacteria S hydrolase of the alpha beta superfamily - - - ko:K07018 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4,Thioesterase k59_498199_1 497964.CfE428DRAFT_6524 4.05e-46 151.0 COG2510@1|root,COG2510@2|Bacteria 2|Bacteria EG membrane - - - ko:K08978 - - - - ko00000,ko02000 2.A.7.2 - - EamA k59_498199_2 84751.XP_007876148.1 2.59e-14 75.9 2ERK3@1|root,2SUCI@2759|Eukaryota,3AQQ1@33154|Opisthokonta,3PGIU@4751|Fungi,3VB49@5204|Basidiomycota,3N599@452284|Ustilaginomycotina 4751|Fungi S Sensors of blue-light using FAD - - - - - - - - - - - - BLUF k59_498199_3 1122603.ATVI01000005_gene3561 4.87e-50 162.0 COG0346@1|root,COG0346@2|Bacteria,1N3RT@1224|Proteobacteria,1SABQ@1236|Gammaproteobacteria,1X7RW@135614|Xanthomonadales 135614|Xanthomonadales E lactoylglutathione lyase activity - - - - - - - - - - - - - k59_921268_1 1131269.AQVV01000013_gene1719 2.19e-19 87.8 COG0381@1|root,COG0381@2|Bacteria 2|Bacteria M UDP-N-acetylglucosamine 2-epimerase activity wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - AAA_22,Epimerase_2 k59_1100785_1 1123274.KB899412_gene1473 5.84e-10 59.7 COG2201@1|root,COG2201@2|Bacteria 2|Bacteria NT protein-glutamate methylesterase activity cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1100785_2 457421.CBFG_01683 4.43e-21 90.5 COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,269CH@186813|unclassified Clostridiales 186801|Clostridia NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_743643_1 1177179.A11A3_08650 2.96e-57 189.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1XI4E@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_889626_1 159087.Daro_2775 1.06e-185 526.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,2KY94@206389|Rhodocyclales 206389|Rhodocyclales C Aldehyde dehydrogenase family - - 1.2.1.32,1.2.1.85 ko:K10217 ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220 M00038,M00569 R02762,R03889,R05353 RC00218,RC00254 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_889626_2 688245.CtCNB1_3150 4.07e-42 145.0 COG2267@1|root,COG2267@2|Bacteria,1P3EB@1224|Proteobacteria,2VMPW@28216|Betaproteobacteria,4AK4A@80864|Comamonadaceae 28216|Betaproteobacteria I alpha/beta hydrolase fold - - 3.7.1.9 ko:K10216,ko:K18092 ko00362,ko00622,ko00642,ko00643,ko01100,ko01120,ko01220,map00362,map00622,map00642,map00643,map01100,map01120,map01220 M00569 R02604,R05362,R05366,R05865 RC00272,RC00752,RC00753,RC00754,RC00755,RC01337,RC01485 br01602,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_743650_1 1276756.AUEX01000017_gene3648 1.37e-75 230.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,4ABPS@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM sugar transferase - - - ko:K13012 - - - - ko00000,ko01005 - - - Bac_transf k59_1031569_1 640081.Dsui_1304 2.41e-70 218.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,2KUPA@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome - - - - - - - - - - - - Cytochrom_C k59_1134434_1 1000565.METUNv1_03852 2.23e-162 466.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,2KUUV@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_498252_2 1000565.METUNv1_00775 8.24e-66 213.0 COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,2KVEP@206389|Rhodocyclales 206389|Rhodocyclales M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_173840_1 1121035.AUCH01000001_gene1841 5.64e-20 87.8 COG4951@1|root,COG4951@2|Bacteria,1RE15@1224|Proteobacteria,2VSA8@28216|Betaproteobacteria,2KX1C@206389|Rhodocyclales 206389|Rhodocyclales L DNA primase small subunit - - - - - - - - - - - - - k59_173840_2 1123504.JQKD01000007_gene3401 2.25e-21 92.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2VHUR@28216|Betaproteobacteria,4AJWR@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1,MFS_3 k59_66148_1 265072.Mfla_1390 1.12e-32 130.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,2KMCW@206350|Nitrosomonadales 206350|Nitrosomonadales E Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_709192_1 296591.Bpro_4294 5.62e-95 284.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,4AGD2@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, cAMP Regulatory protein - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_994474_1 1157708.KB907451_gene4525 1.14e-62 199.0 COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,2VIHN@28216|Betaproteobacteria,4AB9K@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM metallophosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_2 k59_994474_2 1005048.CFU_4423 4.16e-17 80.1 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VH4K@28216|Betaproteobacteria,472R4@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_923765_2 292.DM42_3368 0.00058 41.6 2BTYF@1|root,32P6V@2|Bacteria,1PIIU@1224|Proteobacteria,2W75K@28216|Betaproteobacteria,1KDVT@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_709204_1 1410618.JNKI01000009_gene44 5.91e-10 59.3 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4H539@909932|Negativicutes 909932|Negativicutes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_598925_1 1448389.BAVQ01000029_gene646 1.03e-08 60.5 COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_241667_1 1163617.SCD_n02858 5.36e-19 81.3 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VUY2@28216|Betaproteobacteria 28216|Betaproteobacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_955827_1 1276756.AUEX01000018_gene2977 3.14e-136 391.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,4AB67@80864|Comamonadaceae 28216|Betaproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_778315_1 1100720.ALKN01000045_gene338 1.94e-63 208.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,4AA63@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - DAO,ETF_QO,FAD_binding_2,NAD_binding_8 k59_1102889_1 926549.KI421517_gene2067 2.25e-52 177.0 COG0743@1|root,COG0743@2|Bacteria,4NG0S@976|Bacteroidetes,47K0A@768503|Cytophagia 976|Bacteroidetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_569754_1 637910.ROD_09271 2.15e-17 78.6 28J11@1|root,2Z8Y4@2|Bacteria,1R54Z@1224|Proteobacteria,1RQAZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3486) - - - - - - - - - - - - DUF3486 k59_569754_2 414684.RC1_1112 2.1e-67 219.0 COG4373@1|root,COG4373@2|Bacteria,1N2KG@1224|Proteobacteria,2TR8M@28211|Alphaproteobacteria,2JPDJ@204441|Rhodospirillales 204441|Rhodospirillales S Mu-like prophage FluMu protein gp28 - - - - - - - - - - - - - k59_105716_1 1487953.JMKF01000065_gene4648 2.71e-11 66.2 COG3629@1|root,COG3629@2|Bacteria,1G5W7@1117|Cyanobacteria 1117|Cyanobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12 k59_423529_1 1122951.ATUE01000008_gene38 2.84e-86 265.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,3NIIZ@468|Moraxellaceae 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_994540_1 1227266.HMPREF1551_00551 7.83e-59 196.0 COG0553@1|root,COG0553@2|Bacteria,4PPQ7@976|Bacteroidetes 976|Bacteroidetes KL Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair - - - - - - - - - - - - - k59_994550_1 1120999.JONM01000001_gene1302 2.34e-12 68.6 COG3511@1|root,COG3511@2|Bacteria,1R2FJ@1224|Proteobacteria,2VWFN@28216|Betaproteobacteria 28216|Betaproteobacteria M phospholipase C - - - - - - - - - - - - Phosphoesterase k59_1034797_1 264198.Reut_A2541 9.18e-87 266.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,1K4ET@119060|Burkholderiaceae 28216|Betaproteobacteria G sorbosone dehydrogenase - - - - - - - - - - - - GSDH,SGL k59_105793_1 452662.SJA_C1-31520 3.1e-99 307.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TRE4@28211|Alphaproteobacteria,2K22C@204457|Sphingomonadales 204457|Sphingomonadales L DNA methylase - - - - - - - - - - - - Mrr_cat,N6_N4_Mtase k59_1102953_1 391735.Veis_3082 5.34e-63 213.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,2VMI9@28216|Betaproteobacteria,4ACCB@80864|Comamonadaceae 28216|Betaproteobacteria P Tonb-dependent hemoglobin transferrin lactoferrin family receptor bhuR - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,STN,TonB_dep_Rec k59_68885_1 1000565.METUNv1_00573 7.28e-26 101.0 COG0791@1|root,COG0791@2|Bacteria,1RJ3U@1224|Proteobacteria,2VSD3@28216|Betaproteobacteria,2KWTG@206389|Rhodocyclales 206389|Rhodocyclales M NLP P60 protein - - - - - - - - - - - - NLPC_P60 k59_68885_2 1000565.METUNv1_00574 1.64e-31 116.0 COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,2KWKU@206389|Rhodocyclales 206389|Rhodocyclales S secreted protein - - - - - - - - - - - - SIMPL k59_599049_1 1000565.METUNv1_03850 1.28e-104 308.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,2KV9H@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_32555_1 46429.BV95_02534 9.14e-32 124.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2U0G1@28211|Alphaproteobacteria,2K2GZ@204457|Sphingomonadales 204457|Sphingomonadales T diguanylate cyclase - - - - - - - - - - - - GAF,GGDEF k59_423622_1 1122951.ATUE01000005_gene1532 2.91e-119 354.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,3NIRM@468|Moraxellaceae 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_955958_1 1121012.AUKX01000069_gene2940 2.71e-05 52.4 COG3209@1|root,COG3209@2|Bacteria,4PDZK@976|Bacteroidetes,1IFI0@117743|Flavobacteriia,23I77@178469|Arenibacter 976|Bacteroidetes M COG3209 Rhs family protein - - - - - - - - - - - - - k59_1137619_2 1121035.AUCH01000009_gene890 8.68e-119 347.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,2KU9A@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_778475_1 614083.AWQR01000021_gene227 6.05e-42 155.0 COG1366@1|root,COG1366@2|Bacteria,1R08G@1224|Proteobacteria,2VIGK@28216|Betaproteobacteria,4AJW0@80864|Comamonadaceae 28216|Betaproteobacteria T STAS domain - - - - - - - - - - - - STAS_2 k59_923921_1 497321.C664_03075 2.73e-25 96.7 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,2VU5Y@28216|Betaproteobacteria,2KWKX@206389|Rhodocyclales 206389|Rhodocyclales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_923921_2 1121004.ATVC01000004_gene1491 2.22e-06 51.2 2A4J7@1|root,30T5U@2|Bacteria,1RGAU@1224|Proteobacteria,2VU2M@28216|Betaproteobacteria,2KR8I@206351|Neisseriales 206351|Neisseriales S Protein of unknown function (DUF3426) - - - - - - - - - - - - DUF3426,zinc_ribbon_5 k59_1137631_1 535289.Dtpsy_1480 5.14e-107 329.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,4A9NH@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_68931_1 420662.Mpe_A1435 1.34e-116 349.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,1KJ4H@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_139921_1 314230.DSM3645_08637 4.46e-85 261.0 COG0714@1|root,COG0714@2|Bacteria,2IY1M@203682|Planctomycetes 203682|Planctomycetes S ATPase associated with - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_994695_1 1120977.JHUX01000007_gene227 6.96e-80 252.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,3NJ24@468|Moraxellaceae 1236|Gammaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1080058_1 1286631.X805_34560 3.95e-98 303.0 COG0524@1|root,COG3892@1|root,COG0524@2|Bacteria,COG3892@2|Bacteria,1MV6I@1224|Proteobacteria,2VMV5@28216|Betaproteobacteria,1KMP6@119065|unclassified Burkholderiales 28216|Betaproteobacteria G pfkB family carbohydrate kinase iolC - 2.7.1.92 ko:K03338 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DUF2090,PfkB k59_112341_1 903818.KI912268_gene3360 1.13e-73 248.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,3Y3IC@57723|Acidobacteria 57723|Acidobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_651732_1 887898.HMPREF0551_1351 1.01e-65 214.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,1KIF5@119060|Burkholderiaceae 28216|Betaproteobacteria P Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1005682_1 614083.AWQR01000043_gene3532 3.62e-106 318.0 COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,2VJN1@28216|Betaproteobacteria,4AAMZ@80864|Comamonadaceae 28216|Betaproteobacteria F Guanine deaminase guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_508697_1 1000565.METUNv1_01506 7.62e-40 149.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,2KUDK@206389|Rhodocyclales 206389|Rhodocyclales H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_470159_1 305700.B447_16006 1.42e-74 224.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,2KWBZ@206389|Rhodocyclales 206389|Rhodocyclales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1111259_1 338969.Rfer_3542 2.06e-108 331.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4AC0U@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_470161_1 1276756.AUEX01000012_gene3541 6.9e-66 218.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,4AADZ@80864|Comamonadaceae 28216|Betaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1005697_1 1000565.METUNv1_02405 2.45e-38 139.0 COG2114@1|root,COG2114@2|Bacteria,1QWGZ@1224|Proteobacteria,2WEJJ@28216|Betaproteobacteria,2KZV9@206389|Rhodocyclales 206389|Rhodocyclales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_827384_1 575589.HMPREF0018_01948 9.85e-75 248.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,3NKI1@468|Moraxellaceae 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_754427_1 1000565.METUNv1_00061 3.94e-92 287.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VHHU@28216|Betaproteobacteria,2KVK7@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_540455_1 1144342.PMI40_02789 3.39e-93 288.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472Z0@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter ybiT - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_1041688_1 1198452.Jab_1c10220 9.21e-70 211.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,474EN@75682|Oxalobacteraceae 28216|Betaproteobacteria P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_292519_1 243159.AFE_2417 1.36e-56 184.0 2EKMV@1|root,33EBK@2|Bacteria,1NMRG@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_5644_2 153948.NAL212_0945 1.4e-79 254.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,2VPEA@28216|Betaproteobacteria,3729T@32003|Nitrosomonadales 28216|Betaproteobacteria O pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_5644_3 1000565.METUNv1_03168 4.92e-294 837.0 COG0642@1|root,COG2205@2|Bacteria,1R8EX@1224|Proteobacteria,2VSAK@28216|Betaproteobacteria 28216|Betaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_9 k59_187380_1 522306.CAP2UW1_0804 1.36e-99 303.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,1KPR2@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_77664_1 1000565.METUNv1_03520 2.3e-134 402.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,2VMV8@28216|Betaproteobacteria,2KVSP@206389|Rhodocyclales 206389|Rhodocyclales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_791643_1 497321.C664_00730 1.27e-33 122.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,2KUNC@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ompR - - ko:K02483,ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_791643_2 1000565.METUNv1_01174 1.39e-142 414.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,2KUEB@206389|Rhodocyclales 206389|Rhodocyclales T Periplasmic domain of Sensor histidine kinase RisS - - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,RisS_PPD k59_651811_1 768066.HELO_3602 9.84e-06 47.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1XJIV@135619|Oceanospirillales 135619|Oceanospirillales E COG2755 Lysophospholipase L1 and related esterases tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_651811_2 65497.JODV01000003_gene4633 4.49e-09 65.1 COG1196@1|root,COG1196@2|Bacteria,2GJBD@201174|Actinobacteria,4DXH7@85010|Pseudonocardiales 201174|Actinobacteria D Domain of Unknown Function (DUF349) - - - - - - - - - - - - DUF349 k59_218369_1 857087.Metme_1183 2.74e-25 105.0 COG0558@1|root,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.34 ko:K07291 ko00562,map00562 - R09670 RC00002,RC00078 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_399602_1 338969.Rfer_2175 3.51e-117 355.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,4AACI@80864|Comamonadaceae 28216|Betaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_899123_1 1266998.ATUJ01000005_gene1193 2.78e-71 227.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2PVIC@265|Paracoccus 28211|Alphaproteobacteria E Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system aglK - - ko:K10235 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.8 - - ABC_tran,TOBE_2 k59_256367_1 426114.THI_3689 5.13e-48 174.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,2W0DD@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_899126_2 748247.AZKH_3257 5.47e-123 357.0 COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,2KV4D@206389|Rhodocyclales 206389|Rhodocyclales P Sulfate ABC transporter inner membrane subunit CysT - - - ko:K02046 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - BPD_transp_1 k59_508783_1 1000565.METUNv1_02807 4.46e-63 210.0 COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria,2KXJC@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - - - - - - - - - - FMN_bind,Fer4_10,Fer4_5 k59_1041715_1 1538295.JY96_07790 3.25e-58 197.0 COG2831@1|root,COG2831@2|Bacteria,1PRBP@1224|Proteobacteria,2VHDS@28216|Betaproteobacteria,1KNA4@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Haemolysin secretion/activation protein ShlB/FhaC/HecB fhaC5 - - - - - - - - - - - POTRA_2,ShlB k59_364972_1 398525.KB900701_gene6821 2.99e-53 179.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_829104_1 1408813.AYMG01000006_gene4250 2.16e-56 196.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1IW9U@117747|Sphingobacteriia 976|Bacteroidetes G Domain of unknown function (DUF4982) - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_654146_1 497964.CfE428DRAFT_6510 4.95e-40 147.0 COG0845@1|root,COG0845@2|Bacteria,46SKN@74201|Verrucomicrobia 74201|Verrucomicrobia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_113682_1 1000565.METUNv1_01248 5.26e-76 236.0 COG3219@1|root,COG3219@2|Bacteria,1PSSQ@1224|Proteobacteria,2WA91@28216|Betaproteobacteria,2KZD2@206389|Rhodocyclales 206389|Rhodocyclales S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_1082539_1 338969.Rfer_0330 2.84e-89 269.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,4AA2I@80864|Comamonadaceae 28216|Betaproteobacteria S Protocatechuate 4,5-dioxygenase ligB - 1.13.11.57,1.13.11.8 ko:K04099,ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA,LigB k59_43481_1 1390370.O203_05580 1.26e-63 204.0 COG0715@1|root,COG0715@2|Bacteria,1QVPH@1224|Proteobacteria,1T2FY@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - - - - - - - - - - - k59_684188_1 977880.RALTA_A0488 6.16e-101 308.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1112368_1 1000565.METUNv1_02707 7.52e-91 280.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,2KV9K@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_6962_1 204773.HEAR2392 2.89e-88 275.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,473ZZ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Sulfite reductase, beta subunit (Hemoprotein) cysI - 1.8.1.2,1.8.7.1 ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858,R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_862985_1 1000565.METUNv1_03581 4.57e-44 158.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2W9QE@28216|Betaproteobacteria,2KZ9H@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_439852_2 1003195.SCAT_2249 4.72e-37 136.0 COG3740@1|root,COG3740@2|Bacteria,2IH2Z@201174|Actinobacteria 201174|Actinobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - DZR,Peptidase_S78 k59_1042780_1 748658.KB907312_gene2006 1.76e-36 135.0 29597@1|root,2ZSMJ@2|Bacteria,1RKTS@1224|Proteobacteria,1S6FZ@1236|Gammaproteobacteria,1X1KN@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3037) - - - - - - - - - - - - DUF3037 k59_511037_1 543728.Vapar_4073 6.09e-52 182.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,4AB8V@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit fdwB - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_933983_1 1000565.METUNv1_01869 2.42e-155 444.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,2KUTI@206389|Rhodocyclales 206389|Rhodocyclales C Isocitrate/isopropylmalate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1007481_1 1000565.METUNv1_01066 1.06e-79 245.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,2VI48@28216|Betaproteobacteria,2KXHY@206389|Rhodocyclales 206389|Rhodocyclales J Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_511043_1 1218103.CIN01S_16_00270 2.98e-15 74.3 COG2084@1|root,COG2084@2|Bacteria,4NKRT@976|Bacteroidetes,1IIZ7@117743|Flavobacteriia,3ZP13@59732|Chryseobacterium 976|Bacteroidetes I 2-hydroxy-3-oxopropionate reductase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_862993_2 365044.Pnap_0663 4.04e-76 234.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2VIKF@28216|Betaproteobacteria,4AAS4@80864|Comamonadaceae 28216|Betaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_439873_1 1000565.METUNv1_02413 1.77e-97 300.0 COG0457@1|root,COG0457@2|Bacteria,1RKBG@1224|Proteobacteria,2VQFW@28216|Betaproteobacteria,2KWI5@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_1112377_1 1100721.ALKO01000021_gene658 2e-138 407.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,4ABBD@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_541628_1 1268622.AVS7_01747 5.44e-67 208.0 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,4ACAI@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the ompA family ompA - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_189712_1 864051.BurJ1DRAFT_2900 5.01e-104 314.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KJUJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_900685_1 1000565.METUNv1_03297 8.02e-51 187.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales 206389|Rhodocyclales KNT COG0643 Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_471579_1 1198452.Jab_1c00780 9.87e-127 396.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,476EW@75682|Oxalobacteraceae 28216|Betaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_43519_1 1000565.METUNv1_02906 6.62e-123 355.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,2KVGB@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_863026_2 1195246.AGRI_11987 4.1e-20 91.3 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,465FU@72275|Alteromonadaceae 1236|Gammaproteobacteria K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_1007514_1 1000565.METUNv1_02589 6.54e-132 375.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,2KVJD@206389|Rhodocyclales 206389|Rhodocyclales EH anthranilate trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1007514_2 1000565.METUNv1_02590 1.13e-95 287.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,2KUC1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_439918_1 1198452.Jab_1c21170 4.72e-21 91.7 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,4740U@75682|Oxalobacteraceae 28216|Betaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_257771_2 1000565.METUNv1_01234 2.59e-129 371.0 COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2VNEC@28216|Betaproteobacteria,2KVSG@206389|Rhodocyclales 206389|Rhodocyclales P Binding-protein-dependent transport system inner membrane component - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_934015_2 509635.N824_04765 5.14e-29 115.0 COG1649@1|root,COG1649@2|Bacteria,4NJ45@976|Bacteroidetes,1IPI1@117747|Sphingobacteriia 976|Bacteroidetes S Sialate O-acetylesterase - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - SASA k59_829170_2 864051.BurJ1DRAFT_0730 9.73e-36 130.0 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VJXC@28216|Betaproteobacteria,1KKCS@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_511118_1 1000565.METUNv1_01666 1.88e-110 337.0 COG2982@1|root,COG2982@2|Bacteria,1RD61@1224|Proteobacteria,2VS09@28216|Betaproteobacteria,2KWG8@206389|Rhodocyclales 206389|Rhodocyclales M AsmA-like C-terminal region - - - - - - - - - - - - AsmA_2 k59_471598_1 1121004.ATVC01000093_gene735 1.63e-17 81.3 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,2KQ5E@206351|Neisseriales 206351|Neisseriales S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_863053_2 398512.JQKC01000004_gene5189 3.24e-06 49.3 COG1397@1|root,COG1397@2|Bacteria,1TQXG@1239|Firmicutes,24C2X@186801|Clostridia,3WJBQ@541000|Ruminococcaceae 186801|Clostridia O ADP-ribosylglycohydrolase - - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_511134_1 497964.CfE428DRAFT_4284 6.37e-113 339.0 COG0674@1|root,COG0674@2|Bacteria,46SM9@74201|Verrucomicrobia 74201|Verrucomicrobia C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_577059_1 365046.Rta_08000 8.07e-107 328.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,4AB9A@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM type II and III secretion system protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_427974_1 1254432.SCE1572_13250 2.6e-199 659.0 COG0001@1|root,COG0604@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0604@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,43E1T@68525|delta/epsilon subdivisions,2X7HJ@28221|Deltaproteobacteria,2Z3M9@29|Myxococcales 28221|Deltaproteobacteria Q Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_247162_2 640081.Dsui_0887 1.39e-48 156.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,2KWWQ@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_247162_3 652103.Rpdx1_0805 2.7e-05 46.2 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,3JST2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Belongs to the amidase family MA20_19360 - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_604333_1 1379858.N508_01901 1.8e-32 124.0 COG0112@1|root,COG0112@2|Bacteria,2GERI@200930|Deferribacteres 200930|Deferribacteres E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_247184_1 640081.Dsui_2816 5.34e-132 397.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_635532_1 1123248.KB893319_gene4049 4.47e-107 321.0 COG1139@1|root,COG1139@2|Bacteria,4NEBT@976|Bacteroidetes,1INSU@117747|Sphingobacteriia 976|Bacteroidetes C iron-sulfur cluster-binding protein - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_428084_1 596153.Alide_2563 7.07e-26 99.8 COG3171@1|root,COG3171@2|Bacteria,1N7Y4@1224|Proteobacteria,2VWZ0@28216|Betaproteobacteria,4AHSC@80864|Comamonadaceae 28216|Betaproteobacteria S Protein with unknown function (DUF469) - - - ko:K09923 - - - - ko00000 - - - DUF469 k59_428084_2 1265502.KB905950_gene888 1.99e-21 85.5 COG2026@1|root,COG2026@2|Bacteria,1N07K@1224|Proteobacteria,2VV3N@28216|Betaproteobacteria,4AIE3@80864|Comamonadaceae 28216|Betaproteobacteria DJ ParE-like toxin of type II bacterial toxin-antitoxin system - - - - - - - - - - - - ParE-like_toxin k59_247288_1 1349767.GJA_3936 1.11e-49 167.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,472Z1@75682|Oxalobacteraceae 28216|Betaproteobacteria S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_247288_2 29581.BW37_02080 5.56e-17 81.6 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,4723W@75682|Oxalobacteraceae 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_961434_1 1198452.Jab_1c19740 7.85e-122 367.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,475CY@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acetyl-coenzyme A synthetase N-terminus prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_604469_1 883126.HMPREF9710_00507 5.41e-70 228.0 COG2866@1|root,COG2866@2|Bacteria,1QHMD@1224|Proteobacteria,2VZP8@28216|Betaproteobacteria,4739U@75682|Oxalobacteraceae 28216|Betaproteobacteria E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_247301_1 321846.PS417_24180 9.69e-53 183.0 28JTB@1|root,2Z9IM@2|Bacteria,1NP81@1224|Proteobacteria,1SCBV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_247301_2 365044.Pnap_4589 2.14e-74 238.0 2DB95@1|root,2Z7UM@2|Bacteria,1MX5I@1224|Proteobacteria,2VMZ7@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_214330_2 1000565.METUNv1_02415 8.07e-50 171.0 COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VMD2@28216|Betaproteobacteria,2KVQP@206389|Rhodocyclales 206389|Rhodocyclales U AAA domain - - - - - - - - - - - - AAA_22 k59_892514_1 477184.KYC_06946 8.33e-38 135.0 2C5U9@1|root,318BZ@2|Bacteria,1RK4D@1224|Proteobacteria,2VKK4@28216|Betaproteobacteria,3T5MX@506|Alcaligenaceae 28216|Betaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_642777_1 1158760.AQXP01000043_gene2027 1.53e-26 119.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF,GGDEF,MASE3,PAS_4,PAS_9 k59_1035306_1 1000565.METUNv1_02003 1.18e-251 698.0 COG3211@1|root,COG3211@2|Bacteria,1R690@1224|Proteobacteria,2VMQX@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,VPEP k59_357205_1 522306.CAP2UW1_2487 9.54e-16 73.6 COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2VTXS@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III nirC - - ko:K19344 - - - - ko00000 - - - Cytochrome_CBB3 k59_357205_2 1387312.BAUS01000002_gene203 1.27e-28 106.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_250086_1 1437882.AZRU01000008_gene2949 1.42e-29 116.0 2CYA9@1|root,32T3V@2|Bacteria,1RGRN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_500004_2 1349767.GJA_3240 2.77e-19 88.6 COG0612@1|root,COG0612@2|Bacteria,1Q9S9@1224|Proteobacteria,2WBVP@28216|Betaproteobacteria,476J2@75682|Oxalobacteraceae 28216|Betaproteobacteria S Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_142995_1 700598.Niako_1982 4.29e-67 213.0 COG0697@1|root,COG0697@2|Bacteria,4NGPQ@976|Bacteroidetes,1IXG8@117747|Sphingobacteriia 976|Bacteroidetes EG EamA-like transporter family - - - - - - - - - - - - EamA k59_535569_1 1000565.METUNv1_01453 8.39e-121 352.0 COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,2VQ7E@28216|Betaproteobacteria,2KWNQ@206389|Rhodocyclales 206389|Rhodocyclales H ATP:dephospho-CoA triphosphoribosyl transferase - - 2.4.2.52 ko:K05966 ko02020,map02020 - R09675 RC00049,RC00063 ko00000,ko00001,ko01000 - - - CitG k59_71580_2 1000565.METUNv1_02374 5.17e-110 322.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,2KW6H@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_642796_1 1005395.CSV86_23744 6.1e-33 131.0 COG2304@1|root,COG2931@1|root,COG5295@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,1S3Q4@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind,VWA_2 k59_286_2 232346.JHQL01000003_gene198 1.42e-27 111.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1XI59@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the GPI family pgi2 - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_178792_1 794903.OPIT5_18175 1e-61 209.0 COG1785@1|root,COG1785@2|Bacteria,46X6W@74201|Verrucomicrobia,3K88S@414999|Opitutae 414999|Opitutae P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_821142_1 1000565.METUNv1_03753 3.56e-232 644.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2WFJ1@28216|Betaproteobacteria,2KVGN@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the UDP-N-acetylglucosamine 2-epimerase family mnaA - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_821142_2 1000565.METUNv1_03752 1.14e-108 324.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,2KUI6@206389|Rhodocyclales 206389|Rhodocyclales U COG3267 Type II secretory pathway, component ExeA - - - - - - - - - - - - AAA_22 k59_71583_1 1000565.METUNv1_02149 3.46e-161 473.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,2KV7T@206389|Rhodocyclales 206389|Rhodocyclales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_71583_2 1000565.METUNv1_02150 7.5e-19 84.7 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - DUF4034,Sel1 k59_535575_1 596154.Alide2_2859 1.87e-70 221.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,4AAT4@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM ABC transporter related lolD - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_999600_1 287.DR97_2326 4.65e-87 274.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1YDE0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c45100 ThiC-associated,ThiC_Rad_SAM k59_749731_1 420324.KI912031_gene2921 1.69e-88 267.0 COG4160@1|root,COG4160@2|Bacteria,1QV6B@1224|Proteobacteria,2U1EA@28211|Alphaproteobacteria,1JUK4@119045|Methylobacteriaceae 28211|Alphaproteobacteria E TIGRFAM polar amino acid ABC transporter, inner membrane subunit occMch - - ko:K10019 ko02010,map02010 M00231 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.5,3.A.1.3.6 - - BPD_transp_1 k59_500033_1 159087.Daro_1934 9.24e-80 269.0 COG0784@1|root,COG3290@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1 k59_571262_1 1000565.METUNv1_00495 3.13e-64 205.0 COG4076@1|root,COG4076@2|Bacteria,1MUS5@1224|Proteobacteria,2VKFK@28216|Betaproteobacteria 28216|Betaproteobacteria S Ribosomal RNA adenine dimethylase - - - - - - - - - - - - Methyltransf_25 k59_892549_1 1000565.METUNv1_00660 9.1e-182 531.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - 4HB_MCP_1,CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_7,PAS_8,PAS_9,Response_reg k59_1071118_2 1000565.METUNv1_03423 6.15e-68 217.0 COG1538@1|root,COG1538@2|Bacteria,1R6S1@1224|Proteobacteria,2VMHP@28216|Betaproteobacteria,2KV9S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_500040_1 1538295.JY96_14780 2.37e-85 257.0 COG2353@1|root,COG2353@2|Bacteria,1RCXN@1224|Proteobacteria,2VS71@28216|Betaproteobacteria,1KNKX@119065|unclassified Burkholderiales 28216|Betaproteobacteria S YceI-like domain - - - - - - - - - - - - YceI k59_285824_1 114615.BRADO6304 4.57e-57 199.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JVS5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_535587_1 1000565.METUNv1_03029 4.61e-137 404.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUI4@206389|Rhodocyclales 206389|Rhodocyclales P COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_500046_1 1286631.X805_28320 3.85e-07 50.1 COG4654@1|root,COG4654@2|Bacteria,1N457@1224|Proteobacteria,2VVMH@28216|Betaproteobacteria,1KM1G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_500046_3 1000565.METUNv1_03476 2.24e-18 83.2 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VHTW@28216|Betaproteobacteria,2KUCA@206389|Rhodocyclales 206389|Rhodocyclales EGP drug resistance transporter - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_214372_1 1000565.METUNv1_00993 9.34e-167 533.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_36004_1 1000565.METUNv1_02711 3.37e-131 387.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales 206389|Rhodocyclales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_36004_2 1000565.METUNv1_02712 5.88e-108 335.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,2KVIZ@206389|Rhodocyclales 206389|Rhodocyclales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_285832_1 1157708.KB907452_gene4013 3.01e-78 247.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,4AAIK@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_500055_1 1000565.METUNv1_03479 8.46e-92 276.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2VK8J@28216|Betaproteobacteria,2KV28@206389|Rhodocyclales 206389|Rhodocyclales J RNA-binding S4 domain-containing protein - - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_821173_1 194867.ALBQ01000003_gene1186 3.19e-11 64.7 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2TSZA@28211|Alphaproteobacteria,2K33A@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_821173_2 1229485.AMYV01000089_gene4538 4.89e-56 182.0 COG1309@1|root,COG1309@2|Bacteria,1PZUN@1224|Proteobacteria,1RY6D@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_428682_1 232721.Ajs_0075 1.85e-110 325.0 COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,2VIHN@28216|Betaproteobacteria,4AB9K@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM metallophosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_2 k59_428682_2 338969.Rfer_0401 1.99e-09 55.5 COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,4ADXE@80864|Comamonadaceae 28216|Betaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_571273_1 1000565.METUNv1_02499 1.81e-47 159.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,2KW2D@206389|Rhodocyclales 206389|Rhodocyclales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_571273_2 1000565.METUNv1_02498 7.91e-260 713.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,2KUAN@206389|Rhodocyclales 206389|Rhodocyclales P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_678372_1 1123367.C666_03215 2.22e-108 341.0 COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,2KY1X@206389|Rhodocyclales 206389|Rhodocyclales E Peptidase M1 membrane alanine aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_321624_2 748247.AZKH_0352 1.63e-43 152.0 COG2010@1|root,COG2010@2|Bacteria,1R48P@1224|Proteobacteria,2VPF4@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_856827_1 762376.AXYL_06319 1.54e-27 103.0 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,3T4NN@506|Alcaligenaceae 28216|Betaproteobacteria S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_856827_2 1000565.METUNv1_02900 2.65e-128 367.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,2KV5C@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_856827_3 1000565.METUNv1_02901 7.19e-46 161.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,2KV0F@206389|Rhodocyclales 206389|Rhodocyclales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_214388_1 322710.Avin_40020 3.95e-195 553.0 COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,1RR7V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ferric reductase - - - - - - - - - - - - FAD_binding_6,FAD_binding_8,Ferric_reduct,NAD_binding_1 k59_571278_1 1000565.METUNv1_00993 1.4e-61 213.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_642870_1 585502.HMPREF0645_2609 1.99e-81 264.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,2FRI5@200643|Bacteroidia 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_339_1 1000565.METUNv1_00806 1.2e-157 451.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,2KU8P@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA ybbB - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_321632_1 1000565.METUNv1_01999 9.16e-39 139.0 COG0840@1|root,COG0840@2|Bacteria,1R5W9@1224|Proteobacteria,2VKQP@28216|Betaproteobacteria,2KVCX@206389|Rhodocyclales 206389|Rhodocyclales NT Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB,MCPsignal k59_36026_1 388051.AUFE01000002_gene433 1.25e-86 270.0 COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2VKSK@28216|Betaproteobacteria,1K1EF@119060|Burkholderiaceae 28216|Betaproteobacteria I Pfam Enoyl-CoA hydratase isomerase boxC - 4.1.2.44 ko:K15513 ko00362,map00362 - R09556 RC03426 ko00000,ko00001,ko01000 - - - ECH_1 k59_36026_2 296591.Bpro_1629 4.01e-67 215.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,4ACAF@80864|Comamonadaceae 28216|Betaproteobacteria S benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_464324_1 1000565.METUNv1_02710 1.91e-05 45.8 COG5490@1|root,COG5490@2|Bacteria,1RI0A@1224|Proteobacteria,2VT2H@28216|Betaproteobacteria,2KWKC@206389|Rhodocyclales 206389|Rhodocyclales S Phasin protein - - - - - - - - - - - - Phasin_2 k59_464324_2 1000565.METUNv1_02711 1.12e-60 203.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales 206389|Rhodocyclales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_928210_1 1267211.KI669560_gene818 3.02e-105 308.0 COG0605@1|root,COG0605@2|Bacteria,4NIWF@976|Bacteroidetes,1IX0J@117747|Sphingobacteriia 976|Bacteroidetes C Iron/manganese superoxide dismutases, alpha-hairpin domain - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_285858_1 1000565.METUNv1_02290 1.8e-187 523.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,2KUUZ@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_856829_2 1000565.METUNv1_03807 5.98e-153 437.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,2KUJ6@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_428705_1 640081.Dsui_2309 9.43e-99 298.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2VJSD@28216|Betaproteobacteria,2KUV8@206389|Rhodocyclales 206389|Rhodocyclales F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_928211_1 338969.Rfer_3607 1.87e-117 349.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,4A9Q6@80864|Comamonadaceae 28216|Betaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_928211_2 1219031.BBJR01000051_gene1478 1.39e-12 63.9 COG1605@1|root,COG1605@2|Bacteria,1N6UE@1224|Proteobacteria,2VUT8@28216|Betaproteobacteria,4AF9C@80864|Comamonadaceae 28216|Betaproteobacteria E Chorismate mutase - - 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R06602 RC01549,RC02148 ko00000,ko00001,ko01000 - - - CM_2 k59_785584_1 644801.Psest_4044 3.48e-163 486.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1Z17A@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_71638_1 1000565.METUNv1_03517 8.58e-51 172.0 28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,2VI32@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM TIGR03790 family protein - - - - - - - - - - - - - k59_500107_1 1000565.METUNv1_02672 1.48e-136 389.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,2KVUZ@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_500107_2 1000565.METUNv1_02671 1.32e-56 186.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2WGGJ@28216|Betaproteobacteria,2KUT8@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_291258_1 1000565.METUNv1_03202 6.17e-104 301.0 COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,2VR6M@28216|Betaproteobacteria,2KWDQ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_291258_2 1000565.METUNv1_03201 2.47e-19 87.8 COG4772@1|root,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,2WGQ6@28216|Betaproteobacteria,2KVN0@206389|Rhodocyclales 206389|Rhodocyclales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_860657_1 595537.Varpa_2989 8.57e-75 239.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2W0CG@28216|Betaproteobacteria,4AGS2@80864|Comamonadaceae 28216|Betaproteobacteria E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 k59_185613_1 1000565.METUNv1_03814 4.44e-120 350.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_718808_1 614083.AWQR01000005_gene1008 2.47e-115 336.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,4ABXP@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1040551_1 1000565.METUNv1_02053 1.77e-100 300.0 COG3394@1|root,COG3394@2|Bacteria,1MX3P@1224|Proteobacteria,2VSK0@28216|Betaproteobacteria,2KX14@206389|Rhodocyclales 206389|Rhodocyclales G YdjC-like protein - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC k59_1040551_2 1000565.METUNv1_02051 2.54e-65 214.0 COG1807@1|root,COG1807@2|Bacteria,1NSSV@1224|Proteobacteria,2WH9S@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_1004234_1 1000565.METUNv1_02485 9.67e-65 205.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,2KVY8@206389|Rhodocyclales 206389|Rhodocyclales S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Rrf2,Virul_fac_BrkB k59_649986_1 1000565.METUNv1_00111 6.39e-246 706.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,2KUEK@206389|Rhodocyclales 206389|Rhodocyclales KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_539626_1 1276756.AUEX01000005_gene2858 1.91e-38 142.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,4AAHN@80864|Comamonadaceae 28216|Betaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_507038_1 1124983.PFLCHA0_c28410 4.8e-145 429.0 COG1765@1|root,COG1944@1|root,COG1765@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,1RN47@1236|Gammaproteobacteria,1YRKM@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O YcaO cyclodehydratase, ATP-ad Mg2+-binding ycaO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047429,GO:0047693,GO:0071704,GO:1901564 - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO k59_790606_1 1123248.KB893386_gene1984 3.63e-79 244.0 COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,1IQE6@117747|Sphingobacteriia 976|Bacteroidetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N k59_1078372_1 1198452.Jab_1c20240 7.93e-107 330.0 COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,472TU@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM CheW-like domain, Response regulator receiver domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, Hpt domain - GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 ko:K03407,ko:K13490 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00509 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_4664_1 1000565.METUNv1_02923 5.65e-70 220.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,2KUAI@206389|Rhodocyclales 206389|Rhodocyclales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_4664_2 1000565.METUNv1_02924 7.16e-53 169.0 COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,2KWXG@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial SH3 domain - - - - - - - - - - - - SH3_4 k59_41163_1 1005048.CFU_0644 3.6e-97 297.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,473XB@75682|Oxalobacteraceae 28216|Betaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_255263_1 420662.Mpe_A2827 9.96e-182 509.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KJYT@119065|unclassified Burkholderiales 28216|Betaproteobacteria C TIGRFAM hydrogenase (NiFe) small subunit (hydA) hoxK GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_362347_1 1235457.C404_27445 1.93e-14 74.3 COG4685@1|root,COG4685@2|Bacteria,1MY31@1224|Proteobacteria,2VNU8@28216|Betaproteobacteria,1K0RN@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2138) - - - - - - - - - - - - DUF2138 k59_575033_1 1000565.METUNv1_03583 1.33e-158 451.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,2KUCP@206389|Rhodocyclales 206389|Rhodocyclales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_860681_1 614083.AWQR01000005_gene962 8.78e-14 69.3 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,4A9PY@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator yiaJ - - - - - - - - - - - HTH_IclR,IclR k59_860681_2 614083.AWQR01000005_gene963 2.05e-95 286.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,4AA5A@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family pbpG - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_610108_1 1449069.JMLO01000020_gene715 1.04e-39 144.0 COG2207@1|root,COG2207@2|Bacteria,2IBP1@201174|Actinobacteria,4FXSG@85025|Nocardiaceae 201174|Actinobacteria K AraC-binding-like domain - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_185669_1 1000565.METUNv1_01855 7.28e-81 255.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUPC@206389|Rhodocyclales 206389|Rhodocyclales T COG2202 FOG PAS PAC domain - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_185669_2 1000565.METUNv1_01858 5.81e-74 231.0 COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,2VMD5@28216|Betaproteobacteria,2KYVC@206389|Rhodocyclales 206389|Rhodocyclales S Flavin containing amine oxidoreductase - - - ko:K06955 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_1110551_1 384765.SIAM614_19331 2.08e-45 158.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2U2AJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_435716_1 523791.Kkor_1502 6.09e-87 273.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1XIID@135619|Oceanospirillales 135619|Oceanospirillales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_469153_1 395495.Lcho_1709 2.21e-153 455.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KJUI@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1110562_2 1000565.METUNv1_02152 4.03e-120 352.0 COG0834@1|root,COG0834@2|Bacteria,1R26Z@1224|Proteobacteria,2VT7R@28216|Betaproteobacteria 28216|Betaproteobacteria ET solute-binding protein - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_1110562_3 1000565.METUNv1_02150 4.25e-34 125.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - DUF4034,Sel1 k59_1004291_1 305700.B447_01286 4.18e-46 149.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,2KWAV@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1004291_2 1000565.METUNv1_02524 1.1e-112 333.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,2KVBW@206389|Rhodocyclales 206389|Rhodocyclales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_507109_1 313624.NSP_14380 9.06e-26 97.8 COG2886@1|root,COG2886@2|Bacteria,1G8FV@1117|Cyanobacteria,1HPCD@1161|Nostocales 1117|Cyanobacteria S Uncharacterised protein family (UPF0175) - - - - - - - - - - - - UPF0175 k59_507109_2 589865.DaAHT2_1862 2.53e-59 189.0 COG2405@1|root,COG2405@2|Bacteria,1NMFQ@1224|Proteobacteria,42VW8@68525|delta/epsilon subdivisions,2WS9D@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF3368) - - - - - - - - - - - - DUF3368 k59_507109_3 159087.Daro_3389 3.25e-12 65.5 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,2KVZN@206389|Rhodocyclales 206389|Rhodocyclales G C4-dicarboxylate transport system - - - - - - - - - - - - DctM k59_398484_1 640081.Dsui_0117 1.12e-52 185.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VQBW@28216|Betaproteobacteria,2KZR7@206389|Rhodocyclales 206389|Rhodocyclales NT Four helix bundle sensory module for signal transduction - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,MCPsignal k59_897948_1 395493.BegalDRAFT_3147 1.22e-51 178.0 COG2199@1|root,COG2199@2|Bacteria 2|Bacteria T diguanylate cyclase activity ytrP - 2.7.7.65 ko:K13069 - - R08057 - ko00000,ko01000 - - - GAF_2,GAF_3,GGDEF,HAMP k59_398486_1 1000565.METUNv1_01849 4.68e-115 334.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2VHU3@28216|Betaproteobacteria,2KUX6@206389|Rhodocyclales 206389|Rhodocyclales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 k59_255296_2 1121875.KB907551_gene1007 2.18e-16 78.6 COG1468@1|root,COG1468@2|Bacteria,4PM88@976|Bacteroidetes,1IJMB@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_435746_1 1236959.BAMT01000012_gene3065 5.63e-184 518.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VMVP@28216|Betaproteobacteria,2KMF9@206350|Nitrosomonadales 206350|Nitrosomonadales G PQQ-like domain - - - - - - - - - - - - PQQ,PQQ_2 k59_1004303_1 1000565.METUNv1_00546 7.58e-37 144.0 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2VIQC@28216|Betaproteobacteria 28216|Betaproteobacteria D tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_76217_1 489825.LYNGBM3L_55310 5.05e-35 140.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M6@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4 k59_610134_1 1123392.AQWL01000002_gene1813 3.77e-10 56.2 COG4327@1|root,COG4327@2|Bacteria,1NQBY@1224|Proteobacteria,2VV4C@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - - - - - - - - - - DUF4212 k59_217782_1 1000565.METUNv1_00997 3.66e-108 315.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VHFT@28216|Betaproteobacteria,2KVRM@206389|Rhodocyclales 206389|Rhodocyclales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.5 ko:K01027,ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_217782_2 1000565.METUNv1_00998 4.61e-55 176.0 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2VII6@28216|Betaproteobacteria,2KWJ4@206389|Rhodocyclales 206389|Rhodocyclales I Coenzyme A transferase - - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_1004315_1 5062.CADAORAP00011880 3.26e-41 154.0 COG5265@1|root,KOG0056@2759|Eukaryota,38D03@33154|Opisthokonta,3NV8N@4751|Fungi,3QJEX@4890|Ascomycota,20AZE@147545|Eurotiomycetes,3S4KJ@5042|Eurotiales 4751|Fungi Q heavy metal hmt1 GO:0000041,GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006950,GO:0007034,GO:0008144,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0015399,GO:0015405,GO:0015440,GO:0015711,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030001,GO:0030554,GO:0031090,GO:0031166,GO:0031224,GO:0031300,GO:0031301,GO:0031310,GO:0032553,GO:0032555,GO:0032559,GO:0033220,GO:0034220,GO:0034486,GO:0034635,GO:0034775,GO:0035443,GO:0035639,GO:0035672,GO:0036094,GO:0036246,GO:0036249,GO:0042221,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0042939,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044604,GO:0046686,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0051716,GO:0055085,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071276,GO:0071585,GO:0071627,GO:0071628,GO:0071702,GO:0071705,GO:0071993,GO:0071994,GO:0071995,GO:0071996,GO:0072337,GO:0072348,GO:0097159,GO:0097237,GO:0097367,GO:0097501,GO:0098588,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:0098754,GO:0098805,GO:0098849,GO:0098852,GO:1901265,GO:1901363,GO:1904680,GO:1990170,GO:1990748 - ko:K05661 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.210 - - ABC_membrane,ABC_tran k59_897969_2 1000565.METUNv1_03396 1.23e-15 75.9 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KUUQ@206389|Rhodocyclales 206389|Rhodocyclales U Involved in the tonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_575064_1 1000565.METUNv1_03797 6.17e-76 235.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,2KVC3@206389|Rhodocyclales 206389|Rhodocyclales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_575064_2 1000565.METUNv1_03796 1.47e-133 380.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2VINI@28216|Betaproteobacteria,2KVKB@206389|Rhodocyclales 206389|Rhodocyclales D cell division ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_575064_3 1000565.METUNv1_03795 2.34e-23 95.9 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,2VNGX@28216|Betaproteobacteria,2KUD0@206389|Rhodocyclales 206389|Rhodocyclales D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_4712_1 1121035.AUCH01000003_gene1143 1.32e-70 223.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,2KVEM@206389|Rhodocyclales 206389|Rhodocyclales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_4712_2 936455.KI421499_gene653 7.17e-09 57.4 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria,3JSY7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 dctP - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_4712_3 1175306.GWL_22190 8.06e-16 76.3 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,474R8@75682|Oxalobacteraceae 28216|Betaproteobacteria G periplasmic dctP - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_790669_1 1349767.GJA_203 8.54e-11 60.5 2C39R@1|root,32UYY@2|Bacteria,1N8ND@1224|Proteobacteria,2VWS2@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_111549_1 1000565.METUNv1_03900 4.06e-80 267.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,2KUFW@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_1040625_1 1207076.ALAT01000231_gene640 5.31e-14 71.6 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_31 k59_575889_1 358220.C380_23860 8.03e-69 232.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE3,PAS_3,PAS_4,PAS_7,PAS_9 k59_651866_1 1286106.MPL1_03870 1.77e-36 132.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,460AW@72273|Thiotrichales 72273|Thiotrichales NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_651866_2 1121035.AUCH01000005_gene210 1.4e-88 270.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KUZY@206389|Rhodocyclales 206389|Rhodocyclales U type II secretion system protein pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_112409_1 1157708.KB907450_gene6080 4.57e-81 252.0 COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2VH5V@28216|Betaproteobacteria,4ACWR@80864|Comamonadaceae 28216|Betaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - ko:K15553 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.2 - - NMT1,NMT1_2 k59_683046_1 1000565.METUNv1_00751 1.02e-89 265.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,2KW72@206389|Rhodocyclales 206389|Rhodocyclales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_719694_2 484018.BACPLE_02292 1.05e-49 174.0 COG3250@1|root,COG3250@2|Bacteria,4NFPC@976|Bacteroidetes,2FPUZ@200643|Bacteroidia,4AMTG@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_437551_1 1304883.KI912532_gene1818 5.62e-11 61.6 COG4564@1|root,COG4564@2|Bacteria,1RBG4@1224|Proteobacteria,2VRWI@28216|Betaproteobacteria,2KX5I@206389|Rhodocyclales 206389|Rhodocyclales T COG0840 Methyl-accepting chemotaxis protein - - - - - - - - - - - - sCache_2 k59_437551_2 1071679.BG57_03715 6.14e-39 147.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,1K0YQ@119060|Burkholderiaceae 28216|Betaproteobacteria KQ PFAM sigma-54 factor interaction domain-containing protein - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_651878_1 582744.Msip34_2325 1.03e-78 241.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,2KKIV@206350|Nitrosomonadales 206350|Nitrosomonadales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_42189_1 358220.C380_03220 3.1e-70 233.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2VHSJ@28216|Betaproteobacteria,4ACTV@80864|Comamonadaceae 28216|Betaproteobacteria V TIGRFAM type I secretion system ATPase - - - ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran k59_932836_1 207954.MED92_12336 4.4e-58 190.0 COG4278@1|root,COG4278@2|Bacteria,1RBTS@1224|Proteobacteria,1S5B5@1236|Gammaproteobacteria,1XJGE@135619|Oceanospirillales 135619|Oceanospirillales H phenylacetate-CoA ligase activity - - - - - - - - - - - - - k59_861550_1 338969.Rfer_0862 2.47e-62 195.0 COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2VQ0V@28216|Betaproteobacteria,4AGUW@80864|Comamonadaceae 28216|Betaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_218405_1 485917.Phep_1456 2.91e-58 202.0 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes,1IQP6@117747|Sphingobacteriia 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_42192_1 1266925.JHVX01000002_gene1083 1.83e-37 140.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,3720B@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_968667_1 748247.AZKH_3437 1.1e-130 374.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,2KW1K@206389|Rhodocyclales 206389|Rhodocyclales T Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_187474_1 911239.CF149_23181 4.75e-23 103.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein bdlA - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3,PAS_4,PAS_9 k59_827489_1 29581.BW37_01446 9.06e-75 241.0 COG1819@1|root,COG1819@2|Bacteria,1MW1K@1224|Proteobacteria,2VMKC@28216|Betaproteobacteria 28216|Betaproteobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - - - - - - - - - - - - Glyco_tran_28_C,UDPGT k59_292584_1 1123248.KB893348_gene270 2.44e-52 174.0 COG1044@1|root,COG1044@2|Bacteria,4NFXA@976|Bacteroidetes,1IVKB@117747|Sphingobacteriia 976|Bacteroidetes M glucosamine N-acyltransferase lpxD1 - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_508857_2 640081.Dsui_3042 3.42e-55 176.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,2KUR2@206389|Rhodocyclales 206389|Rhodocyclales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_683056_1 76114.ebA3572 1.15e-40 137.0 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,2KX0I@206389|Rhodocyclales 206389|Rhodocyclales P protein involved in tolerance to divalent cations cutA1 - - ko:K03926 - - - - ko00000 - - - CutA1 k59_1041753_1 999541.bgla_1g06860 8.09e-52 174.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_5710_2 398578.Daci_1939 6.02e-18 80.5 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - HNH,HNH_5,NinG k59_363461_1 1000565.METUNv1_02816 1e-189 541.0 COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2VIIU@28216|Betaproteobacteria,2KUNF@206389|Rhodocyclales 206389|Rhodocyclales G beta (1-6) glucans synthase - - 3.2.1.58 ko:K01210 ko00500,map00500 - R00308,R03115 RC00467 ko00000,ko00001,ko01000 - - - - k59_861569_1 742159.HMPREF0004_0762 3.41e-42 143.0 COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2VQ0V@28216|Betaproteobacteria,3T4BK@506|Alcaligenaceae 28216|Betaproteobacteria S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family flr - - - - - - - - - - - Flavin_Reduct k59_861569_2 395494.Galf_0056 7.22e-16 72.4 2C84F@1|root,334ZR@2|Bacteria,1N6VS@1224|Proteobacteria,2VWHA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1005852_1 1000565.METUNv1_00682 1.23e-113 347.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,2KU6V@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate pps - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_19372_1 203275.BFO_2880 2.58e-09 58.9 COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,2FN4B@200643|Bacteroidia,22WPY@171551|Porphyromonadaceae 976|Bacteroidetes S Von Willebrand factor type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_19372_2 862515.HMPREF0658_0481 1.68e-06 52.4 COG0457@1|root,COG0457@2|Bacteria,4NH2K@976|Bacteroidetes,2FN6E@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat protein batC - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_229591_1 748247.AZKH_1699 7.09e-36 141.0 COG3598@1|root,COG4643@1|root,COG3598@2|Bacteria,COG4643@2|Bacteria,1R4EA@1224|Proteobacteria,2VKG4@28216|Betaproteobacteria,2KWQR@206389|Rhodocyclales 206389|Rhodocyclales L AAA domain - - - - - - - - - - - - AAA_25,PriCT_2 k59_1093743_1 1417599.U6C6Y4_9CAUD 4e-26 112.0 4QF87@10239|Viruses,4QYZ4@35237|dsDNA viruses no RNA stage,4QPVW@28883|Caudovirales,4QNV3@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_459768_1 1408442.JADE01000005_gene1233 2.19e-07 52.8 COG1442@1|root,COG1442@2|Bacteria,1N02S@1224|Proteobacteria,434C8@68525|delta/epsilon subdivisions,2YSSK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_411020_1 640081.Dsui_2287 8.3e-109 337.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,2KUAW@206389|Rhodocyclales 206389|Rhodocyclales E aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_378474_1 1000565.METUNv1_01400 1.54e-97 293.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,2KU8U@206389|Rhodocyclales 206389|Rhodocyclales F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_944229_1 614083.AWQR01000028_gene3156 3.13e-09 58.5 COG0834@1|root,COG0834@2|Bacteria 2|Bacteria ET amino acid transport - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_944229_2 381666.H16_B1400 3.09e-09 58.2 COG0664@1|root,COG0664@2|Bacteria,1RG5V@1224|Proteobacteria,2VS3W@28216|Betaproteobacteria,1K8H3@119060|Burkholderiaceae 28216|Betaproteobacteria K Crp-like helix-turn-helix domain - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1058682_1 1276756.AUEX01000015_gene1952 3.9e-34 125.0 COG3181@1|root,COG3181@2|Bacteria,1R5K3@1224|Proteobacteria,2VHGB@28216|Betaproteobacteria,4AD5F@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1058682_2 266264.Rmet_5383 5.39e-28 108.0 COG1414@1|root,COG1414@2|Bacteria,1NCG5@1224|Proteobacteria,2VNR7@28216|Betaproteobacteria,1K2VV@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_587050_1 365044.Pnap_1979 2.52e-97 291.0 COG0226@1|root,COG0583@1|root,COG0226@2|Bacteria,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,4ACPS@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, LysR family cmpR - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1058691_1 1396141.BATP01000004_gene5883 2.5e-30 121.0 28J2H@1|root,2Z8YZ@2|Bacteria,46ZAA@74201|Verrucomicrobia,2IU6E@203494|Verrucomicrobiae 203494|Verrucomicrobiae - - - - - - - - - - - - - - - k59_674522_1 614083.AWQR01000034_gene3576 4.82e-95 288.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,4ABRS@80864|Comamonadaceae 28216|Betaproteobacteria P ammonium transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_378495_1 1111069.TCCBUS3UF1_2790 7.6e-36 135.0 COG1055@1|root,COG1055@2|Bacteria,1WIE8@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Arsenical pump membrane protein - - - - - - - - - - - - CitMHS k59_55754_1 1500894.JQNN01000001_gene1436 3.67e-14 75.1 COG3631@1|root,COG3631@2|Bacteria 2|Bacteria S light absorption - - 3.1.1.1 ko:K03088,ko:K03928,ko:K06893,ko:K07222 - - - - ko00000,ko01000,ko03021 - - - Flavin_Reduct,Pyr_redox_3,SnoaL,SnoaL_2 k59_484928_1 267608.RSc1394 5.29e-70 224.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,1K0HW@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM aminotransferase class I and II dapC - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_411037_1 1120977.JHUX01000005_gene2753 1.93e-28 117.0 COG1570@1|root,COG1570@2|Bacteria,1QWH2@1224|Proteobacteria,1T2VA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_411037_2 396588.Tgr7_0630 5.36e-24 95.9 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_55758_1 1157708.KB907450_gene6347 8.69e-96 280.0 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,4ADFN@80864|Comamonadaceae 28216|Betaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_55758_2 887062.HGR_01642 1.4e-22 95.9 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,4AA5M@80864|Comamonadaceae 28216|Betaproteobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_411040_1 1000565.METUNv1_00166 7.63e-54 178.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,2KVQU@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_411040_2 667632.KB890167_gene1569 6.79e-14 69.7 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria,1K11G@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase yibF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_19410_1 614083.AWQR01000007_gene404 1.83e-72 235.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,4ACBD@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family rosB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_766036_1 997296.PB1_17369 3.88e-06 47.0 COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,4HPA3@91061|Bacilli,1ZHVV@1386|Bacillus 91061|Bacilli S Could be involved in insertion of integral membrane proteins into the membrane ytjA - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_876381_1 614083.AWQR01000025_gene3718 9.02e-102 315.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,4AB6C@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_270996_1 555217.Zmob_1063 3.39e-08 55.8 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,2K40W@204457|Sphingomonadales 204457|Sphingomonadales J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_270996_2 1201288.M900_2678 2.36e-10 61.2 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2MSN2@213481|Bdellovibrionales,2WIZ7@28221|Deltaproteobacteria 213481|Bdellovibrionales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_352565_1 1123248.KB893337_gene2406 8.65e-80 252.0 COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,1INNX@117747|Sphingobacteriia 976|Bacteroidetes O chelatase, subunit chli comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_308641_1 1121904.ARBP01000004_gene953 9.28e-38 136.0 COG1845@1|root,COG1845@2|Bacteria,4NFA7@976|Bacteroidetes,47NS2@768503|Cytophagia 976|Bacteroidetes C PFAM cytochrome c oxidase subunit III ctaE - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_308641_2 755732.Fluta_1919 9.01e-18 81.6 COG1845@1|root,COG1845@2|Bacteria,4NDYG@976|Bacteroidetes,1HWXP@117743|Flavobacteriia,2PAN3@246874|Cryomorphaceae 976|Bacteroidetes C Heme copper-type cytochrome quinol oxidase subunit 3 coxP - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_944281_1 358220.C380_17950 1.9e-60 205.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_554993_1 795666.MW7_0980 6.13e-68 211.0 COG5449@1|root,COG5449@2|Bacteria,1PWCX@1224|Proteobacteria,2VP21@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_554993_2 375286.mma_2781 7.03e-43 152.0 28HVV@1|root,2Z820@2|Bacteria,1NMDF@1224|Proteobacteria,2VIVE@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1058765_2 365046.Rta_31560 1.63e-59 193.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,4AB3Z@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_531421_1 1198452.Jab_2c25080 1.42e-55 187.0 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2VH3E@28216|Betaproteobacteria,474HN@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_1019447_1 864073.HFRIS_009854 0.00061 41.2 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,472SV@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1019447_2 29581.BW37_03564 2.63e-78 237.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,474BH@75682|Oxalobacteraceae 28216|Betaproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_732720_1 1317124.DW2_13255 5.15e-24 103.0 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2TRAK@28211|Alphaproteobacteria,2XPFY@285107|Thioclava 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_732720_2 55207.KP22_09075 4.15e-20 85.1 COG0454@1|root,COG0456@2|Bacteria,1RCYQ@1224|Proteobacteria,1S3YJ@1236|Gammaproteobacteria,1MPX7@122277|Pectobacterium 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_484989_1 1000565.METUNv1_02989 2.2e-68 209.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,2KWQI@206389|Rhodocyclales 206389|Rhodocyclales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_484989_2 1000565.METUNv1_02988 1.47e-52 168.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,2KWIS@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_162437_1 589865.DaAHT2_0050 1.67e-45 157.0 COG0834@1|root,COG0834@2|Bacteria,1N0VS@1224|Proteobacteria,42TK3@68525|delta/epsilon subdivisions,2WQS6@28221|Deltaproteobacteria 28221|Deltaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_459898_2 439235.Dalk_2337 5.45e-21 88.2 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2MPZB@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1123503_1 1046724.KB889919_gene201 1.49e-69 227.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,4663F@72275|Alteromonadaceae 1236|Gammaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_911612_1 45157.CMT452CT 2.06e-08 63.5 KOG2373@1|root,KOG2373@2759|Eukaryota 2759|Eukaryota S mitochondrial DNA replication C10orf2 GO:0000002,GO:0000959,GO:0002020,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003690,GO:0003697,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006264,GO:0006268,GO:0006351,GO:0006390,GO:0006725,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019438,GO:0019899,GO:0022607,GO:0031974,GO:0032042,GO:0032392,GO:0032508,GO:0032774,GO:0034214,GO:0034641,GO:0034645,GO:0034654,GO:0042645,GO:0043139,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0051259,GO:0051260,GO:0051276,GO:0051536,GO:0051537,GO:0051540,GO:0065003,GO:0070013,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140053,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,Toprim_2 k59_732729_2 1177179.A11A3_00780 2.65e-74 243.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XHXZ@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_352649_1 1123367.C666_11195 3.63e-80 249.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_876484_1 1000565.METUNv1_03484 9.28e-111 320.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VH2U@28216|Betaproteobacteria,2KUEE@206389|Rhodocyclales 206389|Rhodocyclales KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG ureG - - ko:K03189 - - - - ko00000 - - - cobW k59_271103_1 1137799.GZ78_27785 1.58e-39 131.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1XKHQ@135619|Oceanospirillales 135619|Oceanospirillales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_271103_2 1297742.A176_06058 0.000141 44.3 COG3781@1|root,COG3781@2|Bacteria,1MX91@1224|Proteobacteria,434DU@68525|delta/epsilon subdivisions,2X8U6@28221|Deltaproteobacteria,2Z0EB@29|Myxococcales 28221|Deltaproteobacteria S Bestrophin, RFP-TM, chloride channel - - - ko:K08994 - - - - ko00000,ko02000 1.A.46.2 - - Bestrophin k59_944335_2 472759.Nhal_0950 5.7e-09 54.7 COG4197@1|root,COG4197@2|Bacteria,1NHWQ@1224|Proteobacteria,1SGGD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT - - - - - - - - - - - - YdaS_antitoxin k59_587166_1 375286.mma_2067 6.24e-86 282.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,473PX@75682|Oxalobacteraceae 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_271110_1 1000565.METUNv1_02660 0.0 942.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,2KUPN@206389|Rhodocyclales 206389|Rhodocyclales NU COG3170 Tfp pilus assembly protein FimV - - - ko:K08086 - - - - ko00000 - - - LysM k59_531563_1 305900.GV64_02520 3.67e-18 87.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XIQW@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_531563_2 388413.ALPR1_19218 1.29e-19 87.8 COG0524@1|root,COG0524@2|Bacteria,4NIHI@976|Bacteroidetes,47NUW@768503|Cytophagia 976|Bacteroidetes G Belongs to the carbohydrate kinase PfkB family - - - - - - - - - - - - PfkB k59_487129_1 1458427.BAWN01000033_gene1908 2.49e-55 195.0 COG0835@1|root,COG0835@2|Bacteria,1QVCF@1224|Proteobacteria,2VK5W@28216|Betaproteobacteria,4ABWH@80864|Comamonadaceae 28216|Betaproteobacteria NT CheW-like domain - - - - - - - - - - - - CheW k59_878354_1 485918.Cpin_6630 7.77e-109 337.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,1IPYI@117747|Sphingobacteriia 976|Bacteroidetes O with chaperone activity ATP-binding subunit clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_355705_1 1201290.M902_1558 2.36e-79 248.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2MSSE@213481|Bdellovibrionales,2WIZZ@28221|Deltaproteobacteria 213481|Bdellovibrionales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_128050_1 205922.Pfl01_1784 1.03e-65 207.0 COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,1YPXC@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T ANTAR nasT - - ko:K07183 - - - - ko00000,ko02022 - - - ANTAR,Response_reg k59_1125261_1 243365.CV_2156 2.14e-80 258.0 COG2801@1|root,COG2801@2|Bacteria,1QWUR@1224|Proteobacteria,2VNEY@28216|Betaproteobacteria 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_534431_1 745776.DGo_CA2168 1.05e-37 143.0 COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NU PFAM Bacterial type II secretion system protein F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_622186_1 983917.RGE_08830 3.55e-28 117.0 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG2461@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJCZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_677626_1 1123504.JQKD01000068_gene1697 3.74e-123 385.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,4AC3Z@80864|Comamonadaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1061635_1 1894.JOER01000017_gene4776 3.08e-31 126.0 2B3QR@1|root,31WEA@2|Bacteria,2IMFN@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1037552_1 1042375.AFPL01000006_gene2965 1.35e-08 54.7 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,464PF@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_109121_1 748247.AZKH_3614 2.24e-105 318.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,2WEG5@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1074041_1 1000565.METUNv1_01843 7.89e-232 644.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,2KURG@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the binding-protein-dependent transport system permease family urtC - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_894699_1 472759.Nhal_2265 9.37e-05 45.1 2E5FX@1|root,3307M@2|Bacteria,1N8E5@1224|Proteobacteria,1SE6J@1236|Gammaproteobacteria,1WZI4@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_502926_1 1000565.METUNv1_02668 4.09e-71 224.0 COG3087@1|root,COG3087@2|Bacteria,1QVC5@1224|Proteobacteria,2WGPN@28216|Betaproteobacteria,2KZVW@206389|Rhodocyclales 206389|Rhodocyclales D Sporulation related domain - - - ko:K03749 - - - - ko00000 - - - SPOR k59_502926_2 1000565.METUNv1_02669 4.47e-49 160.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,2KWGU@206389|Rhodocyclales 206389|Rhodocyclales S colicin v production cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_572881_1 1000565.METUNv1_01947 5.02e-184 554.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales 206389|Rhodocyclales E glutamate synthase gls1 - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_324427_1 937777.Deipe_2108 4.34e-15 71.2 COG1555@1|root,COG1555@2|Bacteria,1WK8Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L DNA uptake protein and related DNA-binding - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k59_324427_2 497964.CfE428DRAFT_5344 3.73e-117 341.0 COG0708@1|root,COG0708@2|Bacteria,46TGT@74201|Verrucomicrobia 74201|Verrucomicrobia L PFAM Endonuclease exonuclease phosphatase - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_431397_1 1000565.METUNv1_03860 2.17e-187 535.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VN53@28216|Betaproteobacteria,2KVZK@206389|Rhodocyclales 206389|Rhodocyclales I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_645670_1 649747.HMPREF0083_03412 1.06e-22 107.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1UYQH@1239|Firmicutes,4HDJQ@91061|Bacilli,26WY4@186822|Paenibacillaceae 91061|Bacilli T Domain present in phytochromes and cGMP-specific phosphodiesterases. cckA - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1 k59_1074064_1 1000565.METUNv1_02556 6.72e-69 223.0 COG1639@1|root,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,2KVTS@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HDOD k59_431419_1 365044.Pnap_3390 5.45e-89 269.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,4AAMT@80864|Comamonadaceae 28216|Betaproteobacteria J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_359515_1 1134474.O59_001894 4.81e-49 174.0 COG3509@1|root,COG3509@2|Bacteria,1QW8F@1224|Proteobacteria,1T4DR@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_858479_1 1304877.KI519400_gene374 3.42e-33 124.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Glyco_trans_1_2,Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_359520_2 1454004.AW11_02532 9.58e-10 56.2 2CC6G@1|root,32Y5Q@2|Bacteria,1N79B@1224|Proteobacteria,2VX3K@28216|Betaproteobacteria 28216|Betaproteobacteria S lipoprotein - - - - - - - - - - - - BLIP k59_537907_1 1000565.METUNv1_03549 2.78e-45 157.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KV05@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the methyltransferase superfamily - - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_537907_2 1000565.METUNv1_03550 7.46e-16 73.2 2EEIK@1|root,338CH@2|Bacteria,1N6YP@1224|Proteobacteria,2VWW8@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_608873_1 614083.AWQR01000004_gene898 1.52e-60 192.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,4AAED@80864|Comamonadaceae 28216|Betaproteobacteria L TIGRFAM hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_608873_2 614083.AWQR01000004_gene899 4.24e-39 132.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,2VT2B@28216|Betaproteobacteria,4AEEB@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Type IV pilus assembly PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_325424_1 1123487.KB892857_gene2269 1.33e-08 57.4 2E95F@1|root,333E6@2|Bacteria,1N8N7@1224|Proteobacteria,2VWBC@28216|Betaproteobacteria,2KXMZ@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3619) - - - - - - - - - - - - DUF3619 k59_325424_2 1000565.METUNv1_02476 6.55e-103 301.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,2KW6F@206389|Rhodocyclales 206389|Rhodocyclales K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_73710_1 1121035.AUCH01000006_gene644 1.42e-22 92.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,2KW7R@206389|Rhodocyclales 206389|Rhodocyclales H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_216653_1 1000565.METUNv1_02746 9.85e-301 838.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KUJG@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_216653_2 1000565.METUNv1_02745 1.34e-44 152.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,2KUG4@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_325433_1 1000565.METUNv1_00309 4.07e-40 139.0 COG1309@1|root,COG1309@2|Bacteria,1R67Z@1224|Proteobacteria,2VR8H@28216|Betaproteobacteria,2M02M@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_360320_1 509190.Cseg_3147 1.3e-72 235.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2KF2T@204458|Caulobacterales 204458|Caulobacterales M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - - - - - - - - - - OEP k59_360320_2 765912.Thimo_0488 1.14e-129 378.0 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,1RRE3@1236|Gammaproteobacteria,1WW7T@135613|Chromatiales 135613|Chromatiales U Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_360320_3 1249627.D779_3964 6.16e-20 82.0 2AFFU@1|root,315FZ@2|Bacteria,1Q0ZA@1224|Proteobacteria,1TJXK@1236|Gammaproteobacteria,1WZ6Z@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1656) - - - - - - - - - - - - DUF1656 k59_360320_4 765912.Thimo_0486 4.04e-05 46.2 COG1289@1|root,COG1289@2|Bacteria,1MX9H@1224|Proteobacteria,1RSD7@1236|Gammaproteobacteria,1WXR6@135613|Chromatiales 135613|Chromatiales S Fusaric acid resistance protein - - - - - - - - - - - - FUSC k59_182551_1 865938.Weevi_1925 1.17e-76 238.0 COG0809@1|root,COG0809@2|Bacteria,4NF2T@976|Bacteroidetes,1HYMK@117743|Flavobacteriia 976|Bacteroidetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_646769_1 406817.XNC1_3632 4.58e-119 352.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_432419_1 1000565.METUNv1_03540 4.77e-08 51.2 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KWTC@206389|Rhodocyclales 206389|Rhodocyclales G Phosphotransferase system, mannose fructose-specific component IIA ptsL - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_432419_2 1000565.METUNv1_03539 3.15e-169 475.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,2KUKD@206389|Rhodocyclales 206389|Rhodocyclales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_432419_3 1000565.METUNv1_03538 7.23e-253 716.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2VHGF@28216|Betaproteobacteria,2KV01@206389|Rhodocyclales 206389|Rhodocyclales GM Polysaccharide biosynthesis protein - - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 k59_432419_4 1163617.SCD_n02874 2.49e-89 278.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2VNAG@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM Glycosyl transferase family 4 wbiH - - ko:K13007 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_432419_5 365044.Pnap_3482 1.25e-93 287.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2VJHC@28216|Betaproteobacteria,4ADQU@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM NAD-dependent epimerase dehydratase wbiG - 1.1.1.219,5.1.3.2 ko:K00091,ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_432419_7 1123276.KB893251_gene3643 1.18e-27 115.0 COG0463@1|root,COG0463@2|Bacteria,4PM0H@976|Bacteroidetes,47NHX@768503|Cytophagia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_432419_8 1123255.JHYS01000005_gene711 1.22e-30 129.0 COG0438@1|root,COG1216@1|root,COG2227@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1QP7Y@1224|Proteobacteria,2VMI5@28216|Betaproteobacteria,4AD1A@80864|Comamonadaceae 28216|Betaproteobacteria HM PFAM Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23 k59_432419_9 1000565.METUNv1_03533 1.93e-59 196.0 COG1216@1|root,COG1216@2|Bacteria,1RAIR@1224|Proteobacteria,2VQ7M@28216|Betaproteobacteria 28216|Betaproteobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_752187_1 485918.Cpin_1333 2.25e-46 164.0 COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,1IQR9@117747|Sphingobacteriia 976|Bacteroidetes J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_752187_2 761193.Runsl_3018 1.51e-11 60.5 COG1826@1|root,COG1826@2|Bacteria,4NUNH@976|Bacteroidetes,47S09@768503|Cytophagia 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_752187_3 1121859.KB890738_gene3223 1.53e-05 45.1 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,47QZT@768503|Cytophagia 976|Bacteroidetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_360323_1 1123354.AUDR01000011_gene1493 6.09e-15 76.3 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,1KRE6@119069|Hydrogenophilales 119069|Hydrogenophilales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_680685_1 1112217.PPL19_09802 2.51e-122 363.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1R5X6@1224|Proteobacteria,1S8A3@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal,PAS_3 k59_288950_1 177439.DP0983 2.12e-15 79.0 2EA4Q@1|root,3349M@2|Bacteria,1NEN1@1224|Proteobacteria,42WI0@68525|delta/epsilon subdivisions,2WRFA@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_752198_1 1000565.METUNv1_01297 1.68e-98 288.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,2KV5P@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1109093_1 1191299.AJYX01000119_gene62 8.25e-22 95.5 2ADTC@1|root,313IZ@2|Bacteria,1RJKU@1224|Proteobacteria,1SADY@1236|Gammaproteobacteria,1Y0WH@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_1109093_2 1132855.KB913035_gene131 1.39e-77 255.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,2VJSS@28216|Betaproteobacteria,2KKMH@206350|Nitrosomonadales 206350|Nitrosomonadales L EcoEI R protein C-terminal - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,HSDR_N_2,Helicase_C,ResIII k59_1002084_1 761193.Runsl_1228 5.62e-07 56.2 COG1040@1|root,COG1040@2|Bacteria,4P2I9@976|Bacteroidetes 976|Bacteroidetes S competence protein - - - - - - - - - - - - - k59_573573_1 614083.AWQR01000045_gene2056 1.57e-87 261.0 COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,2VQ8G@28216|Betaproteobacteria,4ABCG@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM phospholipid glycerol acyltransferase - - - - - - - - - - - - Acyltransferase k59_1075154_1 1121948.AUAC01000002_gene1701 5.49e-12 67.4 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,43W4T@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_930420_2 420662.Mpe_A0237 3.33e-81 245.0 COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,2VQHV@28216|Betaproteobacteria,1KKWM@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_1002095_2 980584.AFPB01000162_gene2172 2.05e-05 50.4 COG4585@1|root,COG4585@2|Bacteria,4PI9J@976|Bacteroidetes,1ICUX@117743|Flavobacteriia,4076W@61432|unclassified Flavobacteriaceae 976|Bacteroidetes T Histidine kinase-like ATPases - - - - - - - - - - - - - k59_1075168_1 1000565.METUNv1_02213 1.42e-106 315.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2WGQC@28216|Betaproteobacteria,2KW6Z@206389|Rhodocyclales 206389|Rhodocyclales C Oxidoreductase NAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_1075173_1 1333856.L686_02810 1.02e-54 187.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1S0PB@1236|Gammaproteobacteria,1YZZU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG1538 Outer membrane protein nodT - - - - - - - - - - - OEP k59_467123_1 1528106.JRJE01000031_gene3657 9.76e-09 56.2 COG5002@1|root,COG5002@2|Bacteria,1QUGI@1224|Proteobacteria,2TXRR@28211|Alphaproteobacteria,2JZ3W@204441|Rhodospirillales 204441|Rhodospirillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_325490_1 1000565.METUNv1_02772 6.36e-26 107.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales 206389|Rhodocyclales V COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_325490_2 316058.RPB_3954 2.37e-54 176.0 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,3JUPW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S TPM domain - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase k59_325490_3 1000565.METUNv1_02774 3.3e-92 279.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,2KW9T@206389|Rhodocyclales 206389|Rhodocyclales S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase k59_752223_1 1089550.ATTH01000001_gene812 6.2e-09 62.8 COG1361@1|root,COG4412@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4412@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K07004,ko:K09955,ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Laminin_G_3 k59_752229_1 614083.AWQR01000037_gene3446 4.8e-76 236.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,4AAKV@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_573608_1 648757.Rvan_1492 5.75e-115 338.0 COG0210@1|root,COG1074@1|root,COG0210@2|Bacteria,COG1074@2|Bacteria,1R5VM@1224|Proteobacteria,2TY6N@28211|Alphaproteobacteria 28211|Alphaproteobacteria L UvrD/REP helicase N-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_2945_1 1123504.JQKD01000033_gene5235 8.27e-37 140.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VN6Z@28216|Betaproteobacteria,4AB96@80864|Comamonadaceae 28216|Betaproteobacteria G TIGRFAM membrane-bound PQQ-dependent dehydrogenase, glucose quinate shikimate family - - 1.1.5.2,1.1.5.8 ko:K00117,ko:K05358 ko00030,ko00400,ko01100,ko01110,ko01130,map00030,map00400,map01100,map01110,map01130 - R01873,R02415,R06620 RC00066,RC00154,RC00206 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_573610_1 1000565.METUNv1_01432 1.48e-108 335.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,2KVX3@206389|Rhodocyclales 206389|Rhodocyclales P receptor - - - ko:K16090 - - - - ko00000,ko02000 1.B.14.1.11 - - Plug,TonB_dep_Rec k59_182635_1 1000565.METUNv1_03895 4.68e-108 318.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KW6R@206389|Rhodocyclales 206389|Rhodocyclales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1038503_1 421072.IO89_18640 3.63e-74 238.0 COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,1HZ2G@117743|Flavobacteriia,3HINC@358033|Chryseobacterium 976|Bacteroidetes G O-Glycosyl hydrolase family 30 - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_216698_1 45157.CMW005CT 2.21e-11 67.4 COG0839@1|root,2S66Q@2759|Eukaryota 2759|Eukaryota C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nad6 - 1.6.5.3 ko:K03884 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - Oxidored_q3 k59_467156_2 640081.Dsui_1864 1.47e-78 246.0 COG3287@1|root,COG3287@2|Bacteria,1QUQH@1224|Proteobacteria,2VMN2@28216|Betaproteobacteria,2KUGW@206389|Rhodocyclales 206389|Rhodocyclales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_145520_1 1000565.METUNv1_02876 3.77e-161 460.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,2KUT9@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_717308_1 1504672.669787028 4.39e-79 245.0 COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,4AB1B@80864|Comamonadaceae 28216|Betaproteobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase trxB2 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_396146_1 159087.Daro_1580 1.42e-25 110.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VPAI@28216|Betaproteobacteria,2KVP3@206389|Rhodocyclales 206389|Rhodocyclales T Two-component sensor kinase N-terminal - - 2.7.13.3 ko:K07649 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_646881_1 640081.Dsui_1935 3.57e-20 87.0 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,2KW20@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_717309_1 402626.Rpic_3300 3.42e-29 114.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1K1SJ@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_717309_2 1276756.AUEX01000002_gene635 4.43e-71 215.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,4AA7I@80864|Comamonadaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_930465_1 388051.AUFE01000005_gene1049 4.72e-34 122.0 COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,2VHG4@28216|Betaproteobacteria,1K19R@119060|Burkholderiaceae 28216|Betaproteobacteria S Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation kynB GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase k59_930465_2 29581.BW37_04923 6.34e-55 184.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2VIP0@28216|Betaproteobacteria,472AE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_2972_1 999541.bgla_1g03730 8.65e-31 110.0 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,1K9F0@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the BolA IbaG family yrbA - - - - - - - - - - - BolA k59_156278_2 1502852.FG94_00014 6.67e-15 74.3 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VICP@28216|Betaproteobacteria,472WM@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_450313_1 76114.ebA2865 6.02e-25 100.0 COG1278@1|root,COG1278@2|Bacteria,1RIH7@1224|Proteobacteria,2WFUE@28216|Betaproteobacteria 28216|Betaproteobacteria K Excalibur calcium-binding domain - - - - - - - - - - - - CSD,Excalibur k59_199892_1 1122603.ATVI01000005_gene3790 6.91e-14 70.5 COG3687@1|root,COG3687@2|Bacteria,1R3RM@1224|Proteobacteria,1RY15@1236|Gammaproteobacteria,1X3N3@135614|Xanthomonadales 135614|Xanthomonadales S Predicted metal-dependent hydrolase - - - - - - - - - - - - Metal_hydrol k59_199892_2 525244.HMPREF0023_1346 2.22e-50 164.0 COG2050@1|root,COG2050@2|Bacteria,1RHAN@1224|Proteobacteria,1S79C@1236|Gammaproteobacteria,3NKE3@468|Moraxellaceae 1236|Gammaproteobacteria Q Domain of unknown function (DUF4442) - - - - - - - - - - - - DUF4442 k59_450324_1 420662.Mpe_A0768 5.36e-53 177.0 COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VPBQ@28216|Betaproteobacteria,1KK4Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_450324_2 614083.AWQR01000043_gene3521 1.47e-77 238.0 COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2VIDU@28216|Betaproteobacteria,4AATT@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_800132_1 1267211.KI669560_gene1250 2.98e-81 267.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes 976|Bacteroidetes S PFAM ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_690041_1 1000565.METUNv1_00721 1.44e-52 180.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,2KUJV@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_690041_2 1000565.METUNv1_00720 3.3e-75 228.0 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,2KWFA@206389|Rhodocyclales 206389|Rhodocyclales S UPF0114 protein - - - - - - - - - - - - UPF0114 k59_582005_1 279714.FuraDRAFT_2321 2.67e-50 178.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KQ4R@206351|Neisseriales 206351|Neisseriales I Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding k59_119984_2 1121380.JNIW01000019_gene3484 2.12e-07 53.1 COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus U PFAM Endonuclease Exonuclease phosphatase - - - ko:K07004 - - - - ko00000 - - - Exo_endo_phos,LTD k59_84748_1 1276756.AUEX01000002_gene633 8.43e-06 46.6 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AAD0@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_84748_2 1123504.JQKD01000035_gene2642 2.13e-67 205.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2VR2H@28216|Betaproteobacteria,4ADMD@80864|Comamonadaceae 28216|Betaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_1089864_1 378806.STAUR_5206 6.71e-87 274.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,42NBE@68525|delta/epsilon subdivisions,2WMG2@28221|Deltaproteobacteria,2YUJX@29|Myxococcales 28221|Deltaproteobacteria S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_13335_1 1538295.JY96_08215 7.99e-38 131.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,1KKDE@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_616180_1 365046.Rta_09640 2.47e-32 125.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,4AA27@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_616180_2 614083.AWQR01000021_gene223 2.2e-34 129.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,4AA3W@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_582037_1 640081.Dsui_1096 3.12e-101 326.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales 206389|Rhodocyclales E glutamate synthase gls1 - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_342561_1 221360.RS9917_03083 4.44e-17 83.2 COG1233@1|root,COG1233@2|Bacteria,1G086@1117|Cyanobacteria,1GZAS@1129|Synechococcus 1117|Cyanobacteria Q COG1233 Phytoene dehydrogenase and related proteins crtD - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_405756_1 393595.ABO_0687 1.63e-54 181.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,1S21F@1236|Gammaproteobacteria,1XJVG@135619|Oceanospirillales 135619|Oceanospirillales S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_120025_1 1348657.M622_07465 4.39e-12 63.2 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,2KVY3@206389|Rhodocyclales 206389|Rhodocyclales E Lactoylglutathione lyase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_761900_2 1123367.C666_11880 3.85e-75 230.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,2KUA1@206389|Rhodocyclales 206389|Rhodocyclales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1014445_2 521674.Plim_3267 1.59e-68 217.0 COG3220@1|root,COG3220@2|Bacteria,2IY8B@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_201780_1 535289.Dtpsy_0635 1.93e-37 140.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2VJMQ@28216|Betaproteobacteria,4AB6F@80864|Comamonadaceae 28216|Betaproteobacteria HJM Mur ligase, middle domain protein cphA1 - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Mur_ligase_C,Mur_ligase_M,RimK k59_201780_2 1000565.METUNv1_02690 4.21e-42 144.0 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,2KV0G@206389|Rhodocyclales 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_157593_1 1198452.Jab_2c18200 1.69e-104 325.0 COG4773@1|root,COG4773@2|Bacteria,1NZCG@1224|Proteobacteria,2VIDA@28216|Betaproteobacteria 28216|Betaproteobacteria P siderophore receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,STN,TonB_dep_Rec k59_406764_1 1000565.METUNv1_03396 2.71e-61 203.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KUUQ@206389|Rhodocyclales 206389|Rhodocyclales U Involved in the tonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_523362_1 1121377.KB906408_gene1110 2.38e-10 68.6 COG3437@1|root,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - - ko:K07814 - - - - ko00000,ko02022 - - - GAF,GGDEF,HD,HD_5,PAS_4,PAS_9,Response_reg,TPR_12 k59_523368_2 573413.Spirs_4048 1.61e-14 73.6 COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes 203691|Spirochaetes K RNA polymerase sigma54 factor rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_85879_1 4792.ETI37830 9.02e-60 214.0 KOG4438@1|root,KOG4438@2759|Eukaryota,3Q997@4776|Peronosporales 4776|Peronosporales D Nuf2 family - - - ko:K11548 - - - - ko00000,ko03036 - - - Nuf2 k59_1051277_1 595537.Varpa_0854 2.98e-24 96.7 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIQB@28216|Betaproteobacteria,4AAVP@80864|Comamonadaceae 28216|Betaproteobacteria P polar amino acid ABC transporter, inner membrane subunit gltK - - ko:K10002 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_549327_2 1000565.METUNv1_02406 4.16e-15 73.2 COG2165@1|root,COG2165@2|Bacteria,1RHE1@1224|Proteobacteria,2VSJ6@28216|Betaproteobacteria,2KWRU@206389|Rhodocyclales 206389|Rhodocyclales NU general secretion pathway protein - - - - - - - - - - - - N_methyl k59_940334_2 314278.NB231_04135 3.06e-09 58.9 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1S0W8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_14563_2 935863.AWZR01000005_gene2184 1.89e-14 72.4 COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RP3P@1236|Gammaproteobacteria,1X6QI@135614|Xanthomonadales 135614|Xanthomonadales M COG0791 Cell wall-associated hydrolases (invasion-associated proteins) - - - - - - - - - - - - NLPC_P60 k59_479401_1 1000565.METUNv1_02907 4.31e-123 355.0 COG0637@1|root,COG0637@2|Bacteria,1QTWD@1224|Proteobacteria,2VNTW@28216|Betaproteobacteria,2KW3U@206389|Rhodocyclales 206389|Rhodocyclales S Pyrimidine 5''-nucleotidase - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_479401_2 1000565.METUNv1_02906 1.45e-29 112.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,2KVGB@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_121369_1 614083.AWQR01000009_gene735 7.72e-90 270.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,4ABI2@80864|Comamonadaceae 28216|Betaproteobacteria T protein phosphatase 2C domain protein pppL - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_691388_1 1116472.MGMO_94c00320 1.1e-59 190.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_691388_2 580332.Slit_2885 1.69e-23 97.1 COG1216@1|root,COG1216@2|Bacteria,1NG6M@1224|Proteobacteria,2VQVQ@28216|Betaproteobacteria 28216|Betaproteobacteria S Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_transf_21,Glyco_transf_7C,Glycos_transf_2 k59_201873_1 1005048.CFU_0034 8.39e-15 74.7 COG0737@1|root,COG0737@2|Bacteria,1MU11@1224|Proteobacteria,2VJC2@28216|Betaproteobacteria,475IB@75682|Oxalobacteraceae 28216|Betaproteobacteria F 5'-nucleotidase, C-terminal domain cpdB - 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 - R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_728282_1 1000565.METUNv1_01043 2.93e-56 192.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,2KVU2@206389|Rhodocyclales 206389|Rhodocyclales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_617285_1 29581.BW37_00493 8.25e-138 397.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,4730H@75682|Oxalobacteraceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_801510_1 402626.Rpic_4067 2.75e-57 196.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,1K00K@119060|Burkholderiaceae 28216|Betaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_157666_1 1157708.KB907463_gene728 1.02e-116 344.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,4AAQK@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.2,1.4.1.3 ko:K00260,ko:K00261 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_265765_1 1177179.A11A3_15567 8.44e-10 58.9 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1XHD6@135619|Oceanospirillales 135619|Oceanospirillales K in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_265765_2 62977.ACIAD0833 3.97e-81 246.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,3NII6@468|Moraxellaceae 1236|Gammaproteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_2328 PAPS_reduct k59_940354_1 925409.KI911562_gene1267 3.26e-34 119.0 2E4YQ@1|root,32ZSH@2|Bacteria,4NVKX@976|Bacteroidetes,1ITUK@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_14590_1 1276756.AUEX01000002_gene557 4.38e-76 243.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,4ABBW@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_583091_1 1267211.KI669560_gene2672 7.34e-84 262.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,4NDXQ@976|Bacteroidetes,1IPBW@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_85935_1 1049564.TevJSym_ay00150 2.17e-75 253.0 COG0642@1|root,COG3221@1|root,COG3437@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3221@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J8GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - 2.7.13.3 ko:K10715,ko:K20974 ko02020,ko02024,ko02025,map02020,map02024,map02025 M00517,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,DUF4118,GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_871219_2 925409.KI911562_gene2175 3.43e-69 224.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,1IPEF@117747|Sphingobacteriia 976|Bacteroidetes I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) accD5 - - - - - - - - - - - Carboxyl_trans k59_302688_2 159087.Daro_0736 9.32e-80 238.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria,2KWC5@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_452483_1 640081.Dsui_0366 2.87e-155 475.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_452489_1 296591.Bpro_4142 2.67e-119 356.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHKK@28216|Betaproteobacteria,4AB0A@80864|Comamonadaceae 28216|Betaproteobacteria EGP General substrate transporter proP_2 - - - - - - - - - - - Sugar_tr k59_836312_1 379731.PST_1564 1.33e-36 130.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria,1Z235@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_302707_1 83406.HDN1F_32470 6.72e-89 271.0 COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria 1236|Gammaproteobacteria I hydroxymethylglutaryl-CoA reductase - - 1.1.1.34 ko:K00021 ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976 M00095 R02082 RC00004,RC00644 ko00000,ko00001,ko00002,ko01000 - - - HMG-CoA_red k59_1119461_1 313606.M23134_02972 1.6e-57 184.0 COG2258@1|root,COG2258@2|Bacteria,4NQSE@976|Bacteroidetes,47Q91@768503|Cytophagia 976|Bacteroidetes S MOSC domain - - - - - - - - - - - - MOSC k59_1119461_2 1000565.METUNv1_00703 1.97e-117 340.0 COG3712@1|root,COG3712@2|Bacteria 2|Bacteria PT iron ion homeostasis - - - - - - - - - - - - FecR,TPR_16,TPR_19,TPR_8,TonB_dep_Rec k59_1119461_3 1000565.METUNv1_00702 1.61e-40 147.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_617317_1 397945.Aave_1276 2.21e-22 95.9 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,4AAI5@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_617317_2 1276756.AUEX01000014_gene2965 2.06e-55 186.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,4AAN9@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_666926_1 29581.BW37_03948 3.52e-104 324.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VMUG@28216|Betaproteobacteria,472D6@75682|Oxalobacteraceae 28216|Betaproteobacteria M C-terminal domain of tail specific protease (DUF3340) prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_836333_1 1122951.ATUE01000005_gene1910 2.24e-28 112.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,3NIMU@468|Moraxellaceae 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_836333_2 95619.PM1_0228995 2.43e-56 187.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1051429_1 1502852.FG94_00625 1.08e-46 171.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_302729_1 420662.Mpe_A3467 5.91e-87 273.0 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria,1KMJ9@119065|unclassified Burkholderiales 28216|Betaproteobacteria M repeat protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_265824_1 1123279.ATUS01000001_gene2342 1.59e-19 88.6 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1J4DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_265824_2 1397527.Q670_03500 2.51e-37 139.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1XHGY@135619|Oceanospirillales 135619|Oceanospirillales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_344747_1 1123073.KB899241_gene2827 1.12e-47 169.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,1RSEC@1236|Gammaproteobacteria,1X44S@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_344748_1 1157708.KB907450_gene6285 1.54e-22 97.1 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,4AA77@80864|Comamonadaceae 28216|Betaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_344748_2 397945.Aave_1431 1.8e-08 57.4 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,4AA31@80864|Comamonadaceae 28216|Betaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_201982_1 29581.BW37_05107 1.37e-32 122.0 2E41E@1|root,32YY1@2|Bacteria,1N86P@1224|Proteobacteria,2WFYS@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4398) - - - - - - - - - - - - DUF4398 k59_976852_2 388051.AUFE01000004_gene807 1.47e-59 191.0 COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,2VRMP@28216|Betaproteobacteria,1K198@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_568599_1 1123248.KB893370_gene4986 2.29e-32 127.0 COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,1ITV6@117747|Sphingobacteriia 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1033344_1 640081.Dsui_2001 4.87e-203 572.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,2KUJQ@206389|Rhodocyclales 206389|Rhodocyclales C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_922689_2 1223521.BBJX01000004_gene2553 1.91e-18 83.6 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,4AA9Q@80864|Comamonadaceae 28216|Betaproteobacteria E LAO AO transport system ATPase argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_954618_1 1380387.JADM01000001_gene68 1.92e-67 229.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1XHSP@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS k59_954618_2 1122951.ATUE01000005_gene2239 2.15e-29 105.0 2EFYT@1|root,339QZ@2|Bacteria,1NG9A@1224|Proteobacteria,1SH9T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S MFS transporter HA62_05660 - - - - - - - - - - - - k59_104365_2 1458275.AZ34_14420 2.56e-47 158.0 COG2135@1|root,COG2135@2|Bacteria,1RFZU@1224|Proteobacteria,2VQDU@28216|Betaproteobacteria,4AEPH@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_422422_2 1123248.KB893314_gene3394 3.84e-61 198.0 COG1005@1|root,COG1005@2|Bacteria,4NGK7@976|Bacteroidetes,1IR49@117747|Sphingobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_708032_2 1000565.METUNv1_02097 2.2e-161 456.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,2KVHR@206389|Rhodocyclales 206389|Rhodocyclales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_629795_1 882378.RBRH_02282 6.69e-21 84.3 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_629795_2 1121035.AUCH01000003_gene1151 1.99e-61 190.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales 206389|Rhodocyclales FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_891490_1 1198452.Jab_2c05600 9.46e-97 301.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2VPBK@28216|Betaproteobacteria,476GH@75682|Oxalobacteraceae 28216|Betaproteobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_922713_2 1123392.AQWL01000012_gene2479 9.84e-10 63.9 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs-related protein - - - - - - - - - - - - RHS,RHS_repeat k59_856087_1 582744.Msip34_1015 7.7e-39 147.0 COG1538@1|root,COG4319@1|root,COG1538@2|Bacteria,COG4319@2|Bacteria,1MYX2@1224|Proteobacteria,2VKDN@28216|Betaproteobacteria,2KM5M@206350|Nitrosomonadales 206350|Nitrosomonadales MU TIGRFAM type I secretion outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP,OmpA k59_708051_2 926549.KI421517_gene2672 1.78e-33 128.0 COG0773@1|root,COG0773@2|Bacteria,4NE1V@976|Bacteroidetes,47KY0@768503|Cytophagia 976|Bacteroidetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_104415_1 595537.Varpa_2077 7.8e-80 259.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4AA18@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_708089_1 1198452.Jab_1c08000 8.58e-109 331.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2W0VY@28216|Betaproteobacteria,476X8@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_954704_1 714943.Mucpa_2623 4.2e-81 265.0 COG0702@1|root,COG0702@2|Bacteria,4NG5U@976|Bacteroidetes,1IRM9@117747|Sphingobacteriia 976|Bacteroidetes GM RagB SusD domain protein - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_104495_1 1267535.KB906767_gene5478 7.35e-33 131.0 COG4191@1|root,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_104497_1 1333998.M2A_2666 1.16e-64 217.0 COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1MV7C@1224|Proteobacteria,2TQM1@28211|Alphaproteobacteria,4BR5W@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C k59_629872_1 649747.HMPREF0083_00803 6.97e-38 130.0 COG1553@1|root,COG1553@2|Bacteria,1VBNX@1239|Firmicutes,4HWVF@91061|Bacilli 91061|Bacilli P DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_67708_1 1121033.AUCF01000001_gene2492 1.09e-127 377.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2JQZQ@204441|Rhodospirillales 204441|Rhodospirillales C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - 1.12.1.2 ko:K00124,ko:K18005 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S k59_708146_1 1636271.A0A0E3M3Z1_9CAUD 8.66e-34 131.0 4QAIK@10239|Viruses,4QPEB@28883|Caudovirales,4QKNC@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_240543_2 690850.Desaf_1933 1.97e-11 65.1 2EU1M@1|root,33MIN@2|Bacteria,1NJDJ@1224|Proteobacteria,43EFR@68525|delta/epsilon subdivisions,2X9EV@28221|Deltaproteobacteria,2MCNA@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_597891_1 1480694.DC28_04260 3.89e-42 155.0 COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes 203691|Spirochaetes S tetratricopeptide repeat - - - - - - - - - - - - Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_283203_1 1349767.GJA_1968 2.94e-55 195.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2VJSU@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_817611_1 232721.Ajs_2260 7.35e-24 95.5 COG2059@1|root,COG2059@2|Bacteria,1RAZW@1224|Proteobacteria,2VQ9R@28216|Betaproteobacteria,4ADJ9@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_67756_1 420662.Mpe_A0377 1.2e-26 103.0 COG1077@1|root,COG1077@2|Bacteria,1RK8H@1224|Proteobacteria,2VT45@28216|Betaproteobacteria,1KP4R@119065|unclassified Burkholderiales 28216|Betaproteobacteria D Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_777203_2 1245471.PCA10_47260 6.46e-86 268.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1YFQF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Aminotransferase class-III - - 2.6.1.113,2.6.1.96 ko:K12256,ko:K16871 ko00250,ko00330,ko00650,ko01100,ko01120,map00250,map00330,map00650,map01100,map01120 M00027 R08714,R10178 RC00008,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_568830_1 443218.AS9A_2385 5.19e-47 160.0 COG0204@1|root,COG0204@2|Bacteria,2GNBB@201174|Actinobacteria,23691@1762|Mycobacteriaceae 201174|Actinobacteria I Acyltransferase - - - - - - - - - - - - DAGAT k59_568830_2 1434929.X946_4206 9.62e-24 99.0 COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,2VHIB@28216|Betaproteobacteria,1K3IW@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2331) - - - - - - - - - - - - DUF2331 k59_1033616_1 706587.Desti_5134 1.43e-47 175.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg k59_954865_1 680198.SCAB_61121 2.29e-09 63.9 28NSD@1|root,2ZBRC@2|Bacteria,2H2FJ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_817672_1 1131553.JIBI01000005_gene2208 1.03e-34 131.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,372HA@32003|Nitrosomonadales 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_817672_2 640081.Dsui_0478 2.46e-64 202.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,2KWKV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_891786_1 1156937.MFUM_60004 4.26e-56 192.0 COG1190@1|root,COG1190@2|Bacteria,46TIA@74201|Verrucomicrobia,37FUW@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia J tRNA synthetases class II (D, K and N) lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_31474_1 29581.BW37_03011 1.01e-161 459.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,476CE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal hpd - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_568886_2 925409.KI911562_gene1859 2.39e-36 132.0 COG0825@1|root,COG0825@2|Bacteria,4NEVU@976|Bacteroidetes,1IP0K@117747|Sphingobacteriia 976|Bacteroidetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_31478_1 1000565.METUNv1_01294 9.92e-100 300.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,2KVYE@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_142265_1 1349767.GJA_3769 9.87e-66 214.0 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJ7P@28216|Betaproteobacteria,4760X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_1105375_1 1392498.JQLH01000001_gene1479 5.37e-29 122.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1HX4C@117743|Flavobacteriia,2PIG1@252356|Maribacter 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_711709_1 1000565.METUNv1_00857 3.67e-65 205.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,2KVE7@206389|Rhodocyclales 28216|Betaproteobacteria M peptidylprolyl isomerase cbf2 - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N_3 k59_34663_1 743299.Acife_2178 1.12e-145 429.0 COG0419@1|root,COG0419@2|Bacteria,1R8F1@1224|Proteobacteria,1RQ6D@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ATPase involved in DNA repair - - - - - - - - - - - - AAA_23 k59_34663_2 743299.Acife_2179 1.31e-101 296.0 2CC7P@1|root,32RUZ@2|Bacteria,1REZA@1224|Proteobacteria,1SBYA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_34663_3 743299.Acife_2180 8.41e-62 199.0 28K0U@1|root,2Z9QP@2|Bacteria,1R4IB@1224|Proteobacteria,1S0W6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_711737_1 688245.CtCNB1_1455 1.08e-07 57.0 2AIAK@1|root,318RG@2|Bacteria,1Q0U0@1224|Proteobacteria,2W5QF@28216|Betaproteobacteria,4AIV3@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_34665_1 1198452.Jab_2c23950 1.34e-83 266.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,472YD@75682|Oxalobacteraceae 28216|Betaproteobacteria N Belongs to the flagella basal body rod proteins family flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_71032_1 886293.Sinac_5652 1.64e-83 273.0 COG2010@1|root,COG2010@2|Bacteria,2IYQJ@203682|Planctomycetes 203682|Planctomycetes C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_1139814_1 1034807.FBFL15_0799 2.09e-14 78.6 COG1345@1|root,COG1404@1|root,COG3291@1|root,COG3391@1|root,COG4412@1|root,COG4625@1|root,COG1345@2|Bacteria,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4412@2|Bacteria,COG4625@2|Bacteria,4NDZC@976|Bacteroidetes,1I0G4@117743|Flavobacteriia,2NT7Y@237|Flavobacterium 976|Bacteroidetes M Pkd domain containing protein - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - CHU_C,He_PIG,fn3 k59_1105445_1 338969.Rfer_2941 1.09e-119 348.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,4AA65@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM ABC transporter related ybhF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_632517_1 1123393.KB891331_gene2974 3.74e-29 109.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,1KRU1@119069|Hydrogenophilales 119069|Hydrogenophilales L Uncharacterised protein family UPF0102 - - - - - - - - - - - - UPF0102 k59_632517_2 640081.Dsui_0253 0.000372 42.0 2DMN0@1|root,32SKB@2|Bacteria,1N2XU@1224|Proteobacteria,2VUWF@28216|Betaproteobacteria,2KWXP@206389|Rhodocyclales 206389|Rhodocyclales S HIRAN - - - - - - - - - - - - HIRAN k59_711802_1 1198452.Jab_2c28820 4.84e-109 321.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,473VV@75682|Oxalobacteraceae 28216|Betaproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C k59_711806_1 359.CN09_17165 2.87e-34 131.0 COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2U050@28211|Alphaproteobacteria,4B74D@82115|Rhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_1105526_1 580332.Slit_0602 1.06e-29 120.0 COG0457@1|root,COG0500@1|root,COG4976@1|root,COG0457@2|Bacteria,COG2226@2|Bacteria,COG4976@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,44WAR@713636|Nitrosomonadales 28216|Betaproteobacteria O repeat-containing protein - - - - - - - - - - - - TPR_1,TPR_8 k59_1105529_1 614083.AWQR01000021_gene213 2.58e-113 335.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,4A9UG@80864|Comamonadaceae 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1105529_2 1223521.BBJX01000001_gene835 9.02e-11 61.2 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,4A9Y5@80864|Comamonadaceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_958088_1 1000565.METUNv1_00546 4.48e-81 265.0 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2VIQC@28216|Betaproteobacteria 28216|Betaproteobacteria D tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_71111_1 159087.Daro_3930 1.34e-51 172.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,2KUD6@206389|Rhodocyclales 206389|Rhodocyclales M epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_71111_2 1266925.JHVX01000004_gene1119 1.25e-11 63.2 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,3738M@32003|Nitrosomonadales 28216|Betaproteobacteria T low molecular weight ptpA GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_425629_1 1235457.C404_15035 5.44e-38 144.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria 28216|Betaproteobacteria P von Willebrand factor, type A cbbO - - - - - - - - - - - VWA,VWA_2 k59_142468_1 1000565.METUNv1_01598 9.85e-14 67.4 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,2KWMD@206389|Rhodocyclales 206389|Rhodocyclales O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_142468_2 159087.Daro_3994 0.000114 43.1 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,2VY2T@28216|Betaproteobacteria,2KXK6@206389|Rhodocyclales 206389|Rhodocyclales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - - CcmD k59_142468_3 1000565.METUNv1_01600 1.17e-22 94.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,2KV1K@206389|Rhodocyclales 206389|Rhodocyclales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_1139945_1 1000565.METUNv1_03397 1.75e-64 201.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,2KWKV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_958149_1 400668.Mmwyl1_1087 2.34e-06 54.7 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3300@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3300@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XJ4N@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,Response_reg k59_958179_2 927704.SELR_18440 3.85e-24 100.0 COG3935@1|root,COG3935@2|Bacteria,1TQ65@1239|Firmicutes,4H6KQ@909932|Negativicutes 909932|Negativicutes L N-terminal phage replisome organiser (Phage_rep_org_N) - - - - - - - - - - - - Phage_rep_org_N k59_71201_1 358220.C380_10570 6.21e-76 239.0 COG0477@1|root,COG2814@2|Bacteria,1PE5A@1224|Proteobacteria,2VHTJ@28216|Betaproteobacteria,4AA6H@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily emrB_1 - - - - - - - - - - - MFS_1,Sugar_tr k59_997366_1 1033730.CAHG01000006_gene1142 2.79e-05 45.4 COG4977@1|root,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_1005377_1 95619.PM1_0201405 3.82e-93 285.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Glutamate synthase gltD GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3503,iYL1228.KPN_03625 Fer4_11,Fer4_20,Pyr_redox_2 k59_791412_1 1201288.M900_1757 1.47e-92 280.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2MSPZ@213481|Bdellovibrionales,2WJ24@28221|Deltaproteobacteria 213481|Bdellovibrionales GM Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_827062_1 1000565.METUNv1_00935 1.11e-181 525.0 COG0469@1|root,COG2046@1|root,COG0469@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria,2KYGT@206389|Rhodocyclales 206389|Rhodocyclales H PUA-like domain - - - - - - - - - - - - ATP-sulfurylase,PK,PUA_2 k59_827062_2 1000565.METUNv1_00934 2.58e-202 563.0 COG4424@1|root,COG4424@2|Bacteria,1QVF4@1224|Proteobacteria,2VMVK@28216|Betaproteobacteria,2KXTD@206389|Rhodocyclales 206389|Rhodocyclales S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_827062_3 330214.NIDE4078 9.84e-06 47.4 29802@1|root,2ZV65@2|Bacteria 2|Bacteria - - - - - ko:K07090 - - - - ko00000 - - - TauE k59_791420_1 1000565.METUNv1_03764 3.03e-42 150.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,2KVCF@206389|Rhodocyclales 206389|Rhodocyclales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_791420_2 1000565.METUNv1_03765 6.79e-34 127.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VJVY@28216|Betaproteobacteria,2KY04@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_77342_1 426355.Mrad2831_1298 4.36e-62 209.0 COG1835@1|root,COG1835@2|Bacteria,1R4WZ@1224|Proteobacteria,2VF7I@28211|Alphaproteobacteria,1JU5B@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM acyltransferase 3 - - - - - - - - - - - - Acyl_transf_3 k59_1111127_1 1267211.KI669560_gene364 5.6e-18 79.7 COG0563@1|root,COG0563@2|Bacteria,4NG7J@976|Bacteroidetes,1IRJW@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,Pribosyltran k59_1111127_2 1349785.BAUG01000023_gene1481 2.33e-05 48.5 COG1257@1|root,COG1257@2|Bacteria,4NGNG@976|Bacteroidetes,1HY0M@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the HMG-CoA reductase family mvaA - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_610640_1 614083.AWQR01000038_gene1403 1.26e-126 369.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,4ACWA@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM MucB RseB family protein rseB - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_575685_1 1244869.H261_20190 5.5e-63 205.0 COG3391@1|root,COG3391@2|Bacteria,1P6I0@1224|Proteobacteria,2TR05@28211|Alphaproteobacteria,2JVX8@204441|Rhodospirillales 204441|Rhodospirillales S Quinohemoprotein amine dehydrogenase - - - - - - - - - - - - - k59_187004_1 1276756.AUEX01000018_gene3023 4.27e-55 172.0 COG0254@1|root,COG0254@2|Bacteria,1MZ4D@1224|Proteobacteria,2VU3I@28216|Betaproteobacteria,4AEG2@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL31 family rpmE2 - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_1041465_1 288000.BBta_2662 7.01e-37 127.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,2U1KF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1041465_2 709797.CSIRO_3307 7.84e-07 50.4 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U63R@28211|Alphaproteobacteria,3JW5Y@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_112212_1 1000565.METUNv1_00885 2.84e-81 251.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria 28216|Betaproteobacteria S aminopeptidase - - - - - - - - - - - - Aminopep k59_292283_1 1121015.N789_12000 1.28e-26 108.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RRAS@1236|Gammaproteobacteria,1X2ZW@135614|Xanthomonadales 135614|Xanthomonadales S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_292283_2 1000565.METUNv1_00880 1.55e-99 295.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,2KWVX@206389|Rhodocyclales 206389|Rhodocyclales M Transglycosylase SLT domain slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - DUF4124,SLT k59_41949_2 748247.AZKH_1699 1.39e-68 229.0 COG3598@1|root,COG4643@1|root,COG3598@2|Bacteria,COG4643@2|Bacteria,1R4EA@1224|Proteobacteria,2VKG4@28216|Betaproteobacteria,2KWQR@206389|Rhodocyclales 206389|Rhodocyclales L AAA domain - - - - - - - - - - - - AAA_25,PriCT_2 k59_5484_1 243365.CV_3797 4.17e-104 319.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KPHG@206351|Neisseriales 206351|Neisseriales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins hflB - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_77386_1 574966.KB898656_gene1430 5.29e-24 101.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1XHJB@135619|Oceanospirillales 135619|Oceanospirillales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_437130_1 358396.C445_12901 1.09e-22 102.0 COG2203@1|root,arCOG02352@1|root,arCOG02360@1|root,arCOG07605@1|root,arCOG02352@2157|Archaea,arCOG02360@2157|Archaea,arCOG02369@2157|Archaea,arCOG07605@2157|Archaea,2XW05@28890|Euryarchaeota 28890|Euryarchaeota T signal transduction histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_4 k59_292307_1 1122951.ATUE01000005_gene2133 1e-72 241.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,3NJ9W@468|Moraxellaceae 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1041495_1 1150600.ADIARSV_2511 2.79e-95 307.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,4NF4F@976|Bacteroidetes,1IPIS@117747|Sphingobacteriia 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_719514_1 925409.KI911562_gene2490 5.24e-24 100.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,1IQZY@117747|Sphingobacteriia 976|Bacteroidetes Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_112238_1 665571.STHERM_c06580 4.34e-38 138.0 COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes 203691|Spirochaetes K transcriptional regulator - - - - - - - - - - - - - k59_968495_1 981336.F944_00042 8.93e-29 105.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,3NN51@468|Moraxellaceae 1236|Gammaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_968495_2 305700.B447_01641 3.42e-62 199.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,2KUD3@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_437145_2 568768.CM001975_gene2316 8.28e-15 71.6 2DCCH@1|root,2ZDP5@2|Bacteria,1P4TH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1111163_1 365046.Rta_19510 5.08e-16 75.5 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,4ABQ3@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_827151_1 1268068.PG5_28380 3.82e-92 288.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,1RNRM@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_5509_1 1000565.METUNv1_03342 4.62e-60 192.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2VRFJ@28216|Betaproteobacteria,2KW3Z@206389|Rhodocyclales 206389|Rhodocyclales HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_363234_1 358220.C380_04350 4.4e-83 248.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,4ADFP@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM Mammalian cell entry related domain protein mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_898922_2 1123037.AUDE01000006_gene1027 9.44e-37 140.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1HX49@117743|Flavobacteriia 976|Bacteroidetes G hydrolase, family 3 nagA - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_827165_1 330214.NIDE3454 1.51e-08 62.4 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_218270_1 338969.Rfer_2016 1.84e-23 103.0 COG3452@1|root,COG5001@1|root,COG3452@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GAF_2,GGDEF,PAS_4,PAS_8,PAS_9 k59_363240_1 279714.FuraDRAFT_0438 1.39e-89 268.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KPTF@206351|Neisseriales 206351|Neisseriales C Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_292342_1 1380387.JADM01000015_gene1634 1.45e-16 78.6 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,1RRRC@1236|Gammaproteobacteria,1XK22@135619|Oceanospirillales 135619|Oceanospirillales M Outer membrane protein W - - - ko:K07275 - - - - ko00000 - - - OmpW k59_292342_2 383407.XOC_4261 1.37e-07 52.8 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1X4KT@135614|Xanthomonadales 135614|Xanthomonadales O Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_754313_1 1446473.JHWH01000024_gene2847 2.84e-98 297.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,2PY33@265|Paracoccus 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_682895_2 1276756.AUEX01000037_gene274 1.75e-42 141.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,2VSCI@28216|Betaproteobacteria,4AEFW@80864|Comamonadaceae 28216|Betaproteobacteria S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_1111175_1 1000565.METUNv1_02492 1.78e-106 311.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,2KUD3@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_1079860_1 156889.Mmc1_1018 7.86e-52 180.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysC - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2 k59_754319_1 159087.Daro_1066 5.89e-89 274.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VMRU@28216|Betaproteobacteria,2KUM1@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase accessory protein rdxA - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_77454_1 1121033.AUCF01000014_gene1226 1.2e-61 217.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWHG@28211|Alphaproteobacteria,2JVDQ@204441|Rhodospirillales 204441|Rhodospirillales T PAS fold - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_2,PHY k59_719552_1 614083.AWQR01000022_gene13 2.62e-112 348.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.2 ko:K01531 - - - - ko00000,ko01000 3.A.3.4 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_77463_1 1000565.METUNv1_00874 1.45e-158 451.0 COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,2VH2D@28216|Betaproteobacteria,2KVGU@206389|Rhodocyclales 206389|Rhodocyclales E glycosyl transferase family - - - - - - - - - - - - Glycos_trans_3N,Glycos_transf_3 k59_861405_1 748247.AZKH_0338 2.86e-25 101.0 COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,2VI4N@28216|Betaproteobacteria,2KZCZ@206389|Rhodocyclales 206389|Rhodocyclales O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_1041564_2 1000565.METUNv1_02434 9.93e-126 360.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,2KUCS@206389|Rhodocyclales 206389|Rhodocyclales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_827228_1 876044.IMCC3088_1442 6.8e-08 56.6 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_827228_2 640081.Dsui_3135 1.21e-19 89.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1111205_1 1000565.METUNv1_00319 1.15e-62 200.0 COG1580@1|root,COG1580@2|Bacteria,1RARK@1224|Proteobacteria,2VTGH@28216|Betaproteobacteria,2KWNP@206389|Rhodocyclales 206389|Rhodocyclales N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_1111208_1 697282.Mettu_1814 2.24e-32 125.0 COG2208@1|root,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,1RX1S@1236|Gammaproteobacteria,1XGHG@135618|Methylococcales 135618|Methylococcales KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - SpoIIE k59_682927_1 365046.Rta_34720 9.86e-41 142.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,2VK51@28216|Betaproteobacteria,4ACIY@80864|Comamonadaceae 28216|Betaproteobacteria L CRISPR-associated protein Cas7 - - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_682927_2 305700.B447_07964 1.28e-10 62.8 28HN3@1|root,2Z7WH@2|Bacteria,1MWH8@1224|Proteobacteria,2VHI2@28216|Betaproteobacteria,2KZHM@206389|Rhodocyclales 206389|Rhodocyclales S CRISPR-associated protein (Cas_Csd1) - - - - - - - - - - - - Cas_Csd1 k59_1079957_1 279714.FuraDRAFT_3724 1.32e-102 307.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KPP0@206351|Neisseriales 206351|Neisseriales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_861424_1 700598.Niako_2922 1.68e-109 330.0 COG1239@1|root,COG1239@2|Bacteria,4NF1J@976|Bacteroidetes,1IQK5@117747|Sphingobacteriia 976|Bacteroidetes H Sigma-54 interaction domain chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - AAA_5,Sigma54_activat k59_293673_2 1396141.BATP01000007_gene5631 4.86e-10 56.6 COG1758@1|root,COG1758@2|Bacteria,46W29@74201|Verrucomicrobia,2IUQD@203494|Verrucomicrobiae 203494|Verrucomicrobiae K RNA polymerase activity - - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_189052_1 1000565.METUNv1_03778 3.16e-17 80.5 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KYI9@206389|Rhodocyclales 206389|Rhodocyclales M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_189052_2 1000565.METUNv1_03779 1.06e-126 372.0 2F1MY@1|root,33UN8@2|Bacteria,1NUMN@1224|Proteobacteria,2W1XE@28216|Betaproteobacteria,2KYNC@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_257356_1 196367.JNFG01000199_gene3571 1.59e-38 134.0 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2VT72@28216|Betaproteobacteria,1K7PJ@119060|Burkholderiaceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_43130_1 688245.CtCNB1_2743 4.87e-62 197.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VIDM@28216|Betaproteobacteria,4AAPG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Amidohydrolase 2 - - 3.1.1.57 ko:K10221 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R04277 RC03110 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_43130_2 358220.C380_22705 3e-46 151.0 COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,2VQ2B@28216|Betaproteobacteria,4ADQC@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Extradiol ring-cleavage dioxygenase LigAB LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_862588_1 614083.AWQR01000011_gene2331 8.99e-138 399.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,4AB3B@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_720599_1 1276756.AUEX01000015_gene1996 3.98e-93 285.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,4AAS7@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM carboxyl transferase pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_611278_1 338969.Rfer_3848 6.81e-93 295.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_683871_1 1000565.METUNv1_00379 1.19e-120 347.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2VIU9@28216|Betaproteobacteria,2KW2K@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_541324_1 292415.Tbd_2069 2.01e-36 131.0 COG3355@1|root,COG3355@2|Bacteria,1N3ME@1224|Proteobacteria,2VTXQ@28216|Betaproteobacteria 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - - k59_541324_2 977880.RALTA_A1819 5.96e-37 137.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,1K18Q@119060|Burkholderiaceae 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_653583_2 688270.Celal_1853 5.24e-26 97.4 2DI4K@1|root,3020V@2|Bacteria,4NV1J@976|Bacteroidetes,1I507@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_576717_1 981369.JQMJ01000004_gene3390 3.39e-33 131.0 COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,2NFGU@228398|Streptacidiphilus 201174|Actinobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_933673_1 1000565.METUNv1_01116 0.0 1052.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,2KV73@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_933673_2 1000565.METUNv1_01115 4.22e-70 212.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,2KWK5@206389|Rhodocyclales 206389|Rhodocyclales C Succinate dehydrogenase, hydrophobic - - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_933673_3 1348657.M622_01910 1.44e-23 91.7 COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,2KWKD@206389|Rhodocyclales 206389|Rhodocyclales C COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_720605_1 558152.IQ37_16455 1.29e-15 75.5 COG1629@1|root,COG1629@2|Bacteria,4NV7C@976|Bacteroidetes,1I3PS@117743|Flavobacteriia,3ZRKZ@59732|Chryseobacterium 976|Bacteroidetes P transport - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_1050134_2 555778.Hneap_1422 7.4e-76 228.0 COG1961@1|root,COG1961@2|Bacteria,1RA63@1224|Proteobacteria,1S6AS@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - - k59_1013889_1 1565129.JSFF01000028_gene692 0.000466 48.1 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,2QASI@267890|Shewanellaceae 1236|Gammaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_939792_1 1005999.GLGR_3588 3.8e-09 62.8 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,1RPC0@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GGDEF,PAS_4,PAS_9 k59_761421_1 1268622.AVS7_04598 1.62e-89 276.0 COG1055@1|root,COG1055@2|Bacteria,1MXKG@1224|Proteobacteria,2VI3Y@28216|Betaproteobacteria,4AB88@80864|Comamonadaceae 28216|Betaproteobacteria P Putative citrate transport arsB - - - - - - - - - - - CitMHS_2 k59_870492_1 62928.azo3000 1.24e-54 191.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2VHVQ@28216|Betaproteobacteria,2KWIP@206389|Rhodocyclales 206389|Rhodocyclales S ErfK YbiS YcfS YnhG family protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_870492_2 596154.Alide2_4290 2.84e-113 343.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,4ABKM@80864|Comamonadaceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1090262_1 1283284.AZUK01000004_gene3057 1.71e-64 200.0 COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,1S6PN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ k59_1050149_1 1000565.METUNv1_03746 1.1e-20 90.1 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VP40@28216|Betaproteobacteria,2KUSJ@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1050149_2 1000565.METUNv1_03747 1.5e-215 602.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VKX2@28216|Betaproteobacteria,2KV6R@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1013898_1 1198452.Jab_2c35200 1.88e-14 68.9 COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2VSCM@28216|Betaproteobacteria,477NV@75682|Oxalobacteraceae 28216|Betaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1013898_2 1500897.JQNA01000002_gene4885 1.75e-43 145.0 COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2VSCM@28216|Betaproteobacteria,1K742@119060|Burkholderiaceae 28216|Betaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_266749_1 1127673.GLIP_0782 4.19e-33 121.0 COG1974@1|root,COG1974@2|Bacteria,1RHIM@1224|Proteobacteria,1RSKU@1236|Gammaproteobacteria,46C4D@72275|Alteromonadaceae 1236|Gammaproteobacteria KT Peptidase S24-like - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_158651_1 640081.Dsui_1531 3.54e-64 217.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV1U@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9,Protoglobin k59_837226_1 1268622.AVS7_01571 3.14e-26 101.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2VSJV@28216|Betaproteobacteria,4ADN2@80864|Comamonadaceae 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_802519_1 536019.Mesop_0893 4.32e-35 133.0 COG0657@1|root,COG0657@2|Bacteria,1R50E@1224|Proteobacteria,2TVAA@28211|Alphaproteobacteria,43QZS@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I alpha/beta hydrolase fold - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_837228_1 114615.BRADO1229 6.67e-60 200.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria,3JVP6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_524983_1 1132855.KB913035_gene132 9.21e-111 332.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria,2KKBY@206350|Nitrosomonadales 206350|Nitrosomonadales V N-6 DNA Methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_668366_1 1198452.Jab_1c10130 1.54e-120 360.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2VH5R@28216|Betaproteobacteria,472DD@75682|Oxalobacteraceae 28216|Betaproteobacteria S protease with the C-terminal PDZ - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_872205_1 640081.Dsui_1177 1e-111 329.0 COG3005@1|root,COG3005@2|Bacteria,1Q8PP@1224|Proteobacteria,2VJG5@28216|Betaproteobacteria,2KUU3@206389|Rhodocyclales 206389|Rhodocyclales C Ethylbenzene dehydrogenase - - - - - - - - - - - - EB_dh k59_762787_1 1349767.GJA_5030 4.46e-64 215.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,472CN@75682|Oxalobacteraceae 28216|Betaproteobacteria M Soluble lytic murein slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_226313_1 543728.Vapar_3609 7.74e-39 136.0 2E50M@1|root,32ZU3@2|Bacteria,1N7SP@1224|Proteobacteria,2VTYV@28216|Betaproteobacteria,4AEYB@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1091329_1 1457393.AZ09_10760 7.18e-15 75.5 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,2JQ65@204441|Rhodospirillales 204441|Rhodospirillales E Amino-transferase class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_346225_1 1177154.Y5S_02991 5.4e-74 249.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis protein histidine kinase and related chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1015455_1 240016.ABIZ01000001_gene2759 6.58e-117 344.0 COG0825@1|root,COG0825@2|Bacteria,46SE1@74201|Verrucomicrobia,2IU0V@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit - - - - - - - - - - - - ACCA k59_51911_2 1000565.METUNv1_00280 3.34e-108 322.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,2KUJ5@206389|Rhodocyclales 206389|Rhodocyclales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nasF - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2,TAT_signal k59_1015456_1 265072.Mfla_0658 4.56e-104 320.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,2KKJD@206350|Nitrosomonadales 206350|Nitrosomonadales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_1015456_2 1000565.METUNv1_02143 9.15e-115 332.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria,2KXPV@206389|Rhodocyclales 206389|Rhodocyclales U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_15549_1 643867.Ftrac_3154 1.13e-35 135.0 COG4772@1|root,COG4772@2|Bacteria,4NG13@976|Bacteroidetes,47MUX@768503|Cytophagia 976|Bacteroidetes P TIGRFAM Bacteroidetes-specific - - - - - - - - - - - - PorP_SprF k59_668438_1 522306.CAP2UW1_2205 1.35e-33 126.0 COG0745@1|root,COG0745@2|Bacteria,1QIP8@1224|Proteobacteria,2VNRG@28216|Betaproteobacteria 28216|Betaproteobacteria KT CRISPR-associated protein NE0113 (Cas_NE0113) - - - - - - - - - - - - Cas_NE0113 k59_266819_1 1267211.KI669560_gene933 5.14e-32 120.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,1INNM@117747|Sphingobacteriia 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_86872_2 1000565.METUNv1_00199 1.47e-52 170.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VHQ0@28216|Betaproteobacteria,2KWH6@206389|Rhodocyclales 206389|Rhodocyclales K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_346265_1 375286.mma_0683 1.41e-113 337.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,472EZ@75682|Oxalobacteraceae 28216|Betaproteobacteria E Aminotransferase class-III argD - 2.6.1.11,2.6.1.17,2.6.1.81 ko:K00821,ko:K00840 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04217,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_346267_1 1122201.AUAZ01000040_gene3809 8.82e-11 63.5 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,463YV@72275|Alteromonadaceae 1236|Gammaproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_1015476_1 883126.HMPREF9710_02620 2.59e-74 246.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria 1224|Proteobacteria P Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_872272_1 640081.Dsui_3338 6.82e-80 239.0 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,2KWI7@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ - - - - - - - - - - - NUDIX k59_1120314_1 1255043.TVNIR_2416 1.58e-39 151.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_1052956_1 1121897.AUGO01000015_gene3374 3.4e-62 202.0 COG0665@1|root,COG0665@2|Bacteria,4NEEY@976|Bacteroidetes,1HZ4W@117743|Flavobacteriia,2NT6F@237|Flavobacterium 976|Bacteroidetes E Oxidoreductase - - - - - - - - - - - - DAO k59_454020_1 1408473.JHXO01000013_gene570 3.12e-90 276.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,2FNEC@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_346304_1 397945.Aave_4736 1.39e-102 312.0 COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,4ABE1@80864|Comamonadaceae 28216|Betaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_374770_1 926549.KI421517_gene1185 8.65e-31 125.0 COG4775@1|root,COG4775@2|Bacteria,4NF35@976|Bacteroidetes,47NVM@768503|Cytophagia 976|Bacteroidetes M Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,POTRA,ShlB k59_668482_1 644966.Tmar_1363 1.75e-12 70.9 COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,25EPJ@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase, group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_454032_1 1349767.GJA_584 1.54e-101 316.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,2VHID@28216|Betaproteobacteria,473RT@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA polymerase type-B family polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_158748_1 338969.Rfer_2975 6.4e-64 207.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,4AAT8@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_158748_2 399795.CtesDRAFT_PD5319 4.39e-61 191.0 COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2VM0T@28216|Betaproteobacteria,4ABFI@80864|Comamonadaceae 28216|Betaproteobacteria S Intracellular protease, PfpI family pfpI - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_583914_1 1123368.AUIS01000004_gene201 1.46e-168 498.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,2NCUA@225057|Acidithiobacillales 225057|Acidithiobacillales NT Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_583914_2 95619.PM1_0229830 4.92e-101 323.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_583914_3 159087.Daro_1144 7.53e-33 120.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2VRAI@28216|Betaproteobacteria,2KW74@206389|Rhodocyclales 206389|Rhodocyclales NT Chemotaxis signal transduction protein - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_941171_1 1000565.METUNv1_01311 1.08e-90 285.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,2KUWJ@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_374777_1 1100721.ALKO01000008_gene2572 2.43e-111 337.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,4AA7F@80864|Comamonadaceae 28216|Betaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_977837_1 1268622.AVS7_04288 1.49e-123 360.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,4AB39@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1052990_1 1187851.A33M_4060 6.81e-31 124.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,3FDP2@34008|Rhodovulum 28211|Alphaproteobacteria NT Two component signalling adaptor domain MA20_10410 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_346320_1 485918.Cpin_6723 7.97e-59 186.0 COG3448@1|root,COG3448@2|Bacteria,4NMHI@976|Bacteroidetes,1IS71@117747|Sphingobacteriia 976|Bacteroidetes T HPP family - - - - - - - - - - - - HPP k59_346320_2 760192.Halhy_5192 0.000112 44.3 COG0782@1|root,COG0782@2|Bacteria,4NQAD@976|Bacteroidetes,1ITI1@117747|Sphingobacteriia 976|Bacteroidetes K Transcription elongation factor - - - - - - - - - - - - GreA_GreB k59_203422_1 583345.Mmol_0885 5.28e-17 82.8 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KKZA@206350|Nitrosomonadales 206350|Nitrosomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1120346_2 1123519.PSJM300_05025 2.47e-34 131.0 COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,1RN4U@1236|Gammaproteobacteria,1Z1C4@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Belongs to the heat shock protein 70 family yegD - - ko:K04046 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_668517_1 471870.BACINT_02969 7.78e-39 145.0 COG4452@1|root,COG4452@2|Bacteria,4NGKY@976|Bacteroidetes,2FN18@200643|Bacteroidia,4AMV6@815|Bacteroidaceae 976|Bacteroidetes V COG COG4452 Inner membrane protein involved in colicin E2 resistance creD - - ko:K06143 - - - - ko00000 - - - CreD k59_203442_1 1122951.ATUE01000005_gene1910 3.19e-134 395.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,3NIMU@468|Moraxellaceae 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1015532_1 1198452.Jab_2c16710 8.68e-124 363.0 COG2199@1|root,COG2204@1|root,COG2204@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2W8YT@28216|Betaproteobacteria,476D8@75682|Oxalobacteraceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_4,Response_reg k59_1120356_1 1123487.KB892835_gene3699 7.79e-65 203.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VRHX@28216|Betaproteobacteria,2KWCS@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_550598_1 936455.KI421499_gene3215 1.66e-101 315.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,3JRFR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V ABC transporter - - - ko:K06147,ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.109.1,3.A.1.109.2,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1053024_1 1276756.AUEX01000005_gene2749 7.3e-162 464.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,4AABF@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_692499_1 1276756.AUEX01000031_gene131 2.17e-50 164.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,4AC2D@80864|Comamonadaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_226403_1 640081.Dsui_1940 8.06e-99 297.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,2KUSW@206389|Rhodocyclales 206389|Rhodocyclales E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_158785_1 159087.Daro_2176 9.16e-125 367.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,2VKCP@28216|Betaproteobacteria,2KUA6@206389|Rhodocyclales 206389|Rhodocyclales S This family consists of a number of uncharacterised bacterial proteins. The function of this family is - - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_203460_2 1121011.AUCB01000005_gene2338 5.6e-33 126.0 COG3356@1|root,COG3356@2|Bacteria,4NHGJ@976|Bacteroidetes,1I88B@117743|Flavobacteriia,23GP6@178469|Arenibacter 976|Bacteroidetes S PFAM Neutral alkaline nonlysosomal ceramidase - - - - - - - - - - - - - k59_266902_1 296591.Bpro_0490 2.35e-101 296.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,4AC4Q@80864|Comamonadaceae 28216|Betaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_729280_1 614083.AWQR01000032_gene2899 3.82e-86 276.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,4A9SK@80864|Comamonadaceae 28216|Betaproteobacteria T Signal transduction histidine kinase ntrY - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8 k59_15643_1 886293.Sinac_5628 1.17e-54 184.0 COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,2IX68@203682|Planctomycetes 203682|Planctomycetes G BNR repeat-like domain - - - - - - - - - - - - BNR_2 k59_52025_1 522306.CAP2UW1_2148 8.89e-35 128.0 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,1KQ7Z@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_203502_1 1198452.Jab_2c06020 6.64e-93 301.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,475WM@75682|Oxalobacteraceae 28216|Betaproteobacteria EQ Hydantoinase B/oxoprolinase oplaH - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_122559_2 1120999.JONM01000013_gene2207 7.49e-27 107.0 COG2063@1|root,COG2063@2|Bacteria,1RFQ4@1224|Proteobacteria,2VRUR@28216|Betaproteobacteria,2KTV1@206351|Neisseriales 206351|Neisseriales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation - - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_692536_1 395495.Lcho_4133 3.6e-47 164.0 COG0760@1|root,COG0760@2|Bacteria,1RGNX@1224|Proteobacteria,2VRQU@28216|Betaproteobacteria,1KNFK@119065|unclassified Burkholderiales 28216|Betaproteobacteria M SurA N-terminal domain - - - - - - - - - - - - Rotamase_2,SurA_N_3 k59_346423_1 1198452.Jab_2c01760 1.46e-106 320.0 2AKW1@1|root,31BP8@2|Bacteria,1PW87@1224|Proteobacteria,2WBT9@28216|Betaproteobacteria,476EU@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_346425_1 522373.Smlt4251 1.04e-58 199.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RNQR@1236|Gammaproteobacteria,1X5NM@135614|Xanthomonadales 135614|Xanthomonadales I Putative methyltransferase - - - - - - - - - - - - Hydrolase_4,Methyltransf_20 k59_480698_1 1502770.JQMG01000001_gene2394 3.69e-09 63.2 2BHT9@1|root,32BWX@2|Bacteria,1P5DH@1224|Proteobacteria,2W560@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_348684_1 1288494.EBAPG3_14460 5.76e-56 191.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,372ID@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_348684_2 911239.CF149_08507 2.41e-10 61.6 COG0583@1|root,COG0583@2|Bacteria,1QY35@1224|Proteobacteria,1RNAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator ptxR - - - - - - - - - - - HTH_1,LysR_substrate k59_962946_1 1349767.GJA_5021 7.3e-88 283.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2VIRZ@28216|Betaproteobacteria,473SJ@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_248631_1 103733.JNYO01000020_gene1996 1.14e-30 119.0 COG0529@1|root,COG0529@2|Bacteria,2H7TF@201174|Actinobacteria 201174|Actinobacteria P Adenylylsulphate kinase - - - - - - - - - - - - APS_kinase k59_963020_2 399795.CtesDRAFT_PD3905 6.38e-51 178.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,4A9M7@80864|Comamonadaceae 28216|Betaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_636820_1 930166.CD58_08200 7.71e-89 270.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M acid) synthase neuB - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_248818_1 338969.Rfer_0654 4.6e-31 117.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,4AAU3@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Methylenetetrahydrofolate reductase metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_248818_2 338969.Rfer_0653 1.2e-64 204.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2VK8J@28216|Betaproteobacteria,4ABGG@80864|Comamonadaceae 28216|Betaproteobacteria J Ribosomal RNA methyltransferase RrmJ FtsJ tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_637001_1 365046.Rta_31780 2.78e-100 299.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,4AAKA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_963356_1 640081.Dsui_0956 2.15e-178 507.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2VHMG@28216|Betaproteobacteria,2KVM9@206389|Rhodocyclales 206389|Rhodocyclales C Nitrogenase component 1 type Oxidoreductase - - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_606459_1 640081.Dsui_0566 1.05e-13 71.6 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VNEV@28216|Betaproteobacteria,2KW59@206389|Rhodocyclales 206389|Rhodocyclales H Quinolinate phosphoribosyl transferase, C-terminal domain - - - ko:K03813 - - - - ko00000,ko01000 - - - QRPTase_C,QRPTase_N k59_606459_2 216142.LT40_04245 3.4e-30 118.0 COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,1RRXK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Thiol oxidoreductase - - - - - - - - - - - - DHOR k59_606464_2 925409.KI911562_gene380 1.76e-15 78.2 COG1361@1|root,COG3209@1|root,COG3291@1|root,COG5492@1|root,COG1361@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG5492@2|Bacteria,4NJ47@976|Bacteroidetes,1IPFX@117747|Sphingobacteriia 976|Bacteroidetes N C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,PKD k59_637219_1 1282356.H045_13150 3.57e-48 177.0 COG1216@1|root,COG3754@1|root,COG1216@2|Bacteria,COG3754@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1YNG9@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glyco_trans_1_2,Glycos_transf_2,RgpF k59_606597_2 397945.Aave_1209 1.2e-61 201.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,4ACXV@80864|Comamonadaceae 28216|Betaproteobacteria M Bacterial sugar transferase wcaJ - 2.7.8.40 ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_606633_2 1500894.JQNN01000001_gene981 4.89e-10 60.1 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2VM87@28216|Betaproteobacteria,47405@75682|Oxalobacteraceae 28216|Betaproteobacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_606694_1 1000565.METUNv1_02729 2.42e-101 308.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,2KUBW@206389|Rhodocyclales 206389|Rhodocyclales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_606717_1 1000565.METUNv1_03730 5e-14 67.4 2DSGW@1|root,33G2M@2|Bacteria,1NKRQ@1224|Proteobacteria,2VYBE@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2523) - - - - - - - - - - - - DUF2523 k59_606717_2 1000565.METUNv1_03731 2.63e-69 220.0 COG0464@1|root,COG0464@2|Bacteria,1QU82@1224|Proteobacteria,2WHSD@28216|Betaproteobacteria,2KW8F@206389|Rhodocyclales 206389|Rhodocyclales O Zonular occludens toxin (Zot) - - - - - - - - - - - - Zot k59_249180_1 1000565.METUNv1_00150 2.51e-79 260.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VPUH@28216|Betaproteobacteria,2KW4J@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_637572_1 1523503.JPMY01000002_gene3942 1.84e-59 216.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_1 k59_428834_1 761193.Runsl_0202 2.41e-75 236.0 COG0176@1|root,COG2905@1|root,COG0176@2|Bacteria,COG2905@2|Bacteria,4NIUX@976|Bacteroidetes,47KKQ@768503|Cytophagia 976|Bacteroidetes GT Transaldolase/Fructose-6-phosphate aldolase - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - CBS,TAL_FSA k59_892695_1 358823.DF19_10850 4.5e-71 214.0 COG3450@1|root,COG3450@2|Bacteria,2II0B@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF861) - - - - - - - - - - - - Cupin_3 k59_892695_2 1144312.PMI09_03717 2.11e-21 92.8 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B9JF@82115|Rhizobiaceae 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_714298_1 420662.Mpe_A3768 3.05e-19 83.2 2EIBB@1|root,313DD@2|Bacteria,1NEYC@1224|Proteobacteria,2WCBT@28216|Betaproteobacteria,1KP5C@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_714298_2 1000565.METUNv1_00786 1.59e-191 555.0 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,2KWN3@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_468_1 1000565.METUNv1_03529 1.52e-97 293.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2VHMH@28216|Betaproteobacteria,2KUA9@206389|Rhodocyclales 206389|Rhodocyclales M NeuB family - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_36129_1 1000565.METUNv1_04002 1.9e-176 501.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria,2KV3N@206389|Rhodocyclales 206389|Rhodocyclales G MOFRL family - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_428842_1 228410.NE2510 2.25e-06 48.5 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,3734D@32003|Nitrosomonadales 28216|Betaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_428842_2 1198452.Jab_1c09560 2.28e-26 103.0 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2VQJU@28216|Betaproteobacteria,474J2@75682|Oxalobacteraceae 28216|Betaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_393079_1 522306.CAP2UW1_3579 2.11e-30 124.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1KQF7@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_393079_2 76114.ebA3572 9.86e-22 88.2 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,2KX0I@206389|Rhodocyclales 206389|Rhodocyclales P protein involved in tolerance to divalent cations cutA1 - - ko:K03926 - - - - ko00000 - - - CutA1 k59_606999_2 596154.Alide2_3708 7.09e-103 309.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,4AFUD@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM UbiA prenyltransferase menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1035516_1 765910.MARPU_00765 6.77e-44 172.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RYYR@1236|Gammaproteobacteria,1X06T@135613|Chromatiales 135613|Chromatiales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,GGDEF,PAS_3 k59_107430_1 1000565.METUNv1_02160 9.96e-69 213.0 COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,2VTFR@28216|Betaproteobacteria,2M011@206389|Rhodocyclales 206389|Rhodocyclales S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_107430_2 1000565.METUNv1_02162 2.09e-67 220.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KVGM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_285987_1 1163617.SCD_n01863 6.48e-05 50.8 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3 k59_214507_1 1000565.METUNv1_00714 9.3e-49 157.0 COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,2VTYJ@28216|Betaproteobacteria,2KWRY@206389|Rhodocyclales 206389|Rhodocyclales U Type II secretion system protein G - - - - - - - - - - - - - k59_71754_1 1000565.METUNv1_02542 2.05e-60 199.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,2KU8B@206389|Rhodocyclales 206389|Rhodocyclales M mechanosensitive - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_71754_2 1000565.METUNv1_02543 2.94e-62 196.0 COG1502@1|root,COG1502@2|Bacteria,1RG6H@1224|Proteobacteria,2VTMJ@28216|Betaproteobacteria,2KZUN@206389|Rhodocyclales 206389|Rhodocyclales I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_514_1 1000565.METUNv1_02006 1.4e-91 293.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KUJZ@206389|Rhodocyclales 206389|Rhodocyclales T Cache 3/Cache 2 fusion domain - - - - - - - - - - - - Cache_3-Cache_2,MCPsignal k59_514_2 1000565.METUNv1_02005 1.05e-98 293.0 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2VHM4@28216|Betaproteobacteria,2KUB4@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ k59_714357_2 645127.ckrop_1618 1.12e-15 74.7 2B5DG@1|root,31Y7V@2|Bacteria,2HZRF@201174|Actinobacteria,22PT9@1653|Corynebacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1071415_1 614083.AWQR01000024_gene2231 1.24e-64 202.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2VSJV@28216|Betaproteobacteria,4ADN2@80864|Comamonadaceae 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_571404_1 1268622.AVS7_03976 5.13e-17 79.3 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,4AAS1@80864|Comamonadaceae 28216|Betaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_571404_2 1000565.METUNv1_00765 3.78e-85 262.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,2KUII@206389|Rhodocyclales 206389|Rhodocyclales E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_500321_1 29581.BW37_02802 2.42e-100 304.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,472HD@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1071425_1 296591.Bpro_0780 9.99e-40 148.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,4AA8D@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1071425_2 399795.CtesDRAFT_PD4402 3e-29 113.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,4ABBB@80864|Comamonadaceae 28216|Betaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_714369_1 1116472.MGMO_19c00070 2.12e-05 45.4 COG1051@1|root,COG1051@2|Bacteria,1MZDA@1224|Proteobacteria,1S6M4@1236|Gammaproteobacteria,1XGR0@135618|Methylococcales 135618|Methylococcales F NUDIX domain - - - - - - - - - - - - NUDIX k59_714369_2 765913.ThidrDRAFT_4527 2.9e-118 345.0 COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,1WYZH@135613|Chromatiales 135613|Chromatiales M Belongs to the glycosyltransferase 26 family - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB k59_571413_1 1304275.C41B8_04631 1.32e-38 150.0 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1S0W8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_749933_1 358220.C380_11515 2.35e-31 130.0 COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG3706@2|Bacteria,1RE33@1224|Proteobacteria,2VRWV@28216|Betaproteobacteria,4AE1D@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,dCache_1 k59_749933_2 1123487.KB892846_gene529 7.12e-20 88.2 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,2KURP@206389|Rhodocyclales 206389|Rhodocyclales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_964063_1 1000565.METUNv1_03886 1.64e-61 197.0 COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2VNAR@28216|Betaproteobacteria,2KWAT@206389|Rhodocyclales 206389|Rhodocyclales ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - - - - - - - - - - SBP_bac_3 k59_964063_2 1000565.METUNv1_03887 2.32e-96 296.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUD5@206389|Rhodocyclales 206389|Rhodocyclales G PQQ-like domain - - - - - - - - - - - - PQQ k59_678514_1 172088.AUGA01000026_gene313 2.58e-22 100.0 COG0438@1|root,COG0438@2|Bacteria,1NJ19@1224|Proteobacteria,2TRT4@28211|Alphaproteobacteria,3JTE2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Gkycosyl transferase family 4 group expC - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_3,Glycos_transf_1 k59_714372_1 1198452.Jab_2c15230 1.67e-66 227.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472RR@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM EAL domain, GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_9,Response_reg k59_1106909_1 1122951.ATUE01000009_gene439 1.23e-150 452.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,3NIHR@468|Moraxellaceae 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_607020_1 1000565.METUNv1_02429 1.67e-124 362.0 COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,2KUXE@206389|Rhodocyclales 206389|Rhodocyclales S Predicted integral membrane protein (DUF2189) - - - - - - - - - - - - DUF2189 k59_607020_2 1000565.METUNv1_02430 1.22e-91 276.0 COG3204@1|root,COG3204@2|Bacteria,1R23A@1224|Proteobacteria,2VS5E@28216|Betaproteobacteria 28216|Betaproteobacteria L pilus organization - - - - - - - - - - - - VPEP k59_607020_3 1000565.METUNv1_02431 1.84e-59 191.0 2EF3F@1|root,338WI@2|Bacteria,1N91Z@1224|Proteobacteria,2W4MP@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_607020_4 1000565.METUNv1_02432 7e-215 598.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHFU@28216|Betaproteobacteria,2KV26@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_964068_1 1000565.METUNv1_01010 1.38e-128 380.0 2DBNG@1|root,2ZA3W@2|Bacteria,1P5DN@1224|Proteobacteria,2VPD3@28216|Betaproteobacteria,2KVWK@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_428938_1 306281.AJLK01000102_gene3416 4.54e-96 300.0 COG0154@1|root,COG0154@2|Bacteria 2|Bacteria J amidase activity - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_428938_2 43989.cce_1138 1.06e-22 104.0 COG0745@1|root,COG0834@1|root,COG4251@1|root,COG0745@2|Bacteria,COG0834@2|Bacteria,COG4251@2|Bacteria,1GHFQ@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg,dCache_1 k59_179110_1 1000565.METUNv1_04049 9.18e-137 397.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,2KXQK@206389|Rhodocyclales 206389|Rhodocyclales H Molybdopterin biosynthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_357510_1 866536.Belba_1151 2.46e-16 77.8 COG0527@1|root,COG0527@2|Bacteria,4NFWR@976|Bacteroidetes,47KM0@768503|Cytophagia 976|Bacteroidetes E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_357510_2 761193.Runsl_0559 1.13e-24 102.0 COG2055@1|root,COG2055@2|Bacteria,4NGVC@976|Bacteroidetes,47KBZ@768503|Cytophagia 976|Bacteroidetes C Belongs to the LDH2 MDH2 oxidoreductase family - - - - - - - - - - - - Ldh_2 k59_643159_1 398578.Daci_1945 1.06e-35 132.0 2DTUK@1|root,33MQ2@2|Bacteria,1NPI3@1224|Proteobacteria,2W420@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_643159_2 1226994.AMZB01000137_gene5401 2.44e-06 48.5 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria 1224|Proteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_561_2 1123229.AUBC01000004_gene3024 1.78e-34 134.0 COG1670@1|root,COG3980@1|root,COG1670@2|Bacteria,COG3980@2|Bacteria,1Q330@1224|Proteobacteria,2U781@28211|Alphaproteobacteria,3K0DP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M COG3980 Spore coat polysaccharide biosynthesis protein - - - - - - - - - - - - Acetyltransf_3,Glyco_tran_28_C k59_1081055_1 1085623.GNIT_0066 9.8e-28 114.0 COG0705@1|root,COG0705@2|Bacteria,1MYPM@1224|Proteobacteria,1RN1K@1236|Gammaproteobacteria,463ZC@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) glpG GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0140096,GO:1901363,GO:1901564,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K02441 - - - - ko00000 - - - NRho,Rhomboid,Rhomboid_N k59_1006470_2 1000565.METUNv1_01502 2.96e-47 155.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,2KVZE@206389|Rhodocyclales 206389|Rhodocyclales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_969063_1 929703.KE386491_gene339 3.13e-47 172.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,47M08@768503|Cytophagia 976|Bacteroidetes S ASPIC UnbV domain protein - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_6148_2 1198232.CYCME_0178 4.65e-81 246.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,460N7@72273|Thiotrichales 72273|Thiotrichales S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_399995_1 596154.Alide2_4163 1.08e-60 211.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,4AD7T@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - 7TMR-DISM_7TM,EAL,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3 k59_78309_1 700598.Niako_4251 4.03e-74 237.0 2DBAQ@1|root,2Z848@2|Bacteria,4NFR9@976|Bacteroidetes,1INQ0@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_683424_1 1158292.JPOE01000002_gene2331 4.35e-137 421.0 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VJ7D@28216|Betaproteobacteria,1KM6H@119065|unclassified Burkholderiales 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_1111674_1 1000565.METUNv1_03750 1.17e-30 118.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VJEB@28216|Betaproteobacteria,2KUMI@206389|Rhodocyclales 206389|Rhodocyclales D COG0489 ATPases involved in chromosome partitioning - - 2.7.10.1 ko:K08252 - - - - ko00000,ko01000 - - - AAA_31 k59_1111674_2 1000565.METUNv1_03749 9.69e-14 70.1 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria,2KUAM@206389|Rhodocyclales 206389|Rhodocyclales M Polysaccharide chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_148287_1 159087.Daro_0996 3.14e-21 88.2 COG2461@1|root,COG2461@2|Bacteria,1QWG2@1224|Proteobacteria,2WGYM@28216|Betaproteobacteria,2KZPV@206389|Rhodocyclales 206389|Rhodocyclales S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_148287_2 62928.azo3086 5.36e-14 67.4 COG4309@1|root,COG4309@2|Bacteria 2|Bacteria D conserved protein (DUF2249) - - - - - - - - - - - - DUF1858,DUF2249 k59_148287_3 768671.ThimaDRAFT_0821 1.77e-16 78.6 COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales 135613|Chromatiales O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_78317_1 1406840.Q763_08140 3.95e-79 249.0 COG0738@1|root,COG0738@2|Bacteria,4NEYR@976|Bacteroidetes,1HY8N@117743|Flavobacteriia,2NSA5@237|Flavobacterium 976|Bacteroidetes G transporter - - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_256893_1 640512.BC1003_5207 4.43e-46 157.0 COG1414@1|root,COG1414@2|Bacteria,1NCG5@1224|Proteobacteria,2VNR7@28216|Betaproteobacteria,1K2VV@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_148301_1 1538295.JY96_19190 1.3e-91 269.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria,1KMAD@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DNA polymerase III, chi subunit holC - 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_78321_1 1000565.METUNv1_03669 8.14e-128 367.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,2KW1Z@206389|Rhodocyclales 206389|Rhodocyclales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_78321_2 1000565.METUNv1_03668 4.52e-106 316.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,2KUAJ@206389|Rhodocyclales 206389|Rhodocyclales C Ubiquinone biosynthesis hydroxylase - - - - - - - - - - - - FAD_binding_2,FAD_binding_3,SE k59_218744_1 762376.AXYL_06276 1.01e-13 75.9 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria,3T345@506|Alcaligenaceae 28216|Betaproteobacteria Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component mlaE_2 - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_218744_2 1121920.AUAU01000022_gene2462 2.57e-05 51.2 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - ko:K02660,ko:K11525 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GAF,GGDEF,HAMP,MCPsignal,PAS_3,PAS_4,PAS_7,dCache_1 k59_509682_1 1144319.PMI16_04286 3.42e-55 187.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,472BW@75682|Oxalobacteraceae 28216|Betaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_828199_1 338969.Rfer_1544 6.81e-90 278.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,4AAJR@80864|Comamonadaceae 28216|Betaproteobacteria S Polyphosphate kinase 2 (PPK2) pap - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_470753_1 305700.B447_12052 5.94e-08 52.8 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,2KU7S@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_470753_2 1238182.C882_3452 4.06e-162 468.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,2JQ2J@204441|Rhodospirillales 204441|Rhodospirillales I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_576322_2 1000565.METUNv1_03997 1.33e-40 143.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales 206389|Rhodocyclales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_540927_1 864051.BurJ1DRAFT_0850 1.81e-35 143.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KJZW@119065|unclassified Burkholderiales 28216|Betaproteobacteria T chemotaxis sensory transducer - - - ko:K03406,ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,HAMP,MCPsignal,PAS_3,PAS_9 k59_754895_1 1000565.METUNv1_00341 7e-144 419.0 COG2204@1|root,COG4585@1|root,COG2204@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,2KWH2@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,PAS_3,PAS_4,Response_reg k59_754895_2 1000565.METUNv1_00340 1.25e-09 57.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,2KW43@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_188327_1 1001585.MDS_4683 9.14e-51 165.0 COG4539@1|root,COG4539@2|Bacteria,1RHUB@1224|Proteobacteria,1S6SU@1236|Gammaproteobacteria,1YG08@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF962) - - - - - - - - - - - - DUF962 k59_188327_2 338969.Rfer_0525 2.05e-13 69.3 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VKGK@28216|Betaproteobacteria,4AC95@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM phospholipase A1 pldA - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_293176_1 1349767.GJA_3853 4.31e-48 159.0 COG1739@1|root,COG1739@2|Bacteria,1NFJC@1224|Proteobacteria,2VKTT@28216|Betaproteobacteria,474ME@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF1949) yigZ - - - - - - - - - - - DUF1949,UPF0029 k59_293176_2 1000565.METUNv1_01442 2.4e-178 503.0 2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2VKQ6@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_652796_1 91464.S7335_2462 8.14e-55 182.0 COG2442@1|root,COG2442@2|Bacteria,1G4E6@1117|Cyanobacteria 1117|Cyanobacteria S Protein of unknown function (DUF433) - - - - - - - - - - - - DUF433 k59_1006545_1 981327.F925_03011 2.66e-60 199.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,3NJGF@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_862121_1 755732.Fluta_2056 9.4e-20 90.9 COG2027@1|root,COG2027@2|Bacteria,4NGIQ@976|Bacteroidetes,1HZBC@117743|Flavobacteriia,2PBD0@246874|Cryomorphaceae 976|Bacteroidetes M D-Ala-D-Ala carboxypeptidase 3 (S13) family dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_256936_1 5786.XP_003288982.1 2.63e-08 60.5 COG0515@1|root,KOG0192@2759|Eukaryota,3XCFS@554915|Amoebozoa 554915|Amoebozoa T Pleckstrin homology domain. - GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - PH,Pkinase_Tyr k59_294457_1 1267534.KB906754_gene3609 7.26e-88 272.0 COG1088@1|root,COG1088@2|Bacteria,3Y3E7@57723|Acidobacteria,2JIRI@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_654744_1 1288494.EBAPG3_29630 1.83e-77 253.0 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2VQ4Y@28216|Betaproteobacteria,374FM@32003|Nitrosomonadales 28216|Betaproteobacteria S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3,Polysacc_synt_C k59_1007819_1 1122951.ATUE01000006_gene1348 1.44e-56 190.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,3NK4U@468|Moraxellaceae 1236|Gammaproteobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_43823_1 1000565.METUNv1_03508 4.63e-108 332.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,2KV3E@206389|Rhodocyclales 206389|Rhodocyclales I Methylmalonyl-CoA mutase mutB - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_721192_1 1000565.METUNv1_00100 6.83e-143 410.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,2KV61@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the SIS family. GutQ KpsF subfamily - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_721192_2 1000565.METUNv1_00099 8.41e-92 271.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,2KWGX@206389|Rhodocyclales 206389|Rhodocyclales S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_654770_1 83406.HDN1F_28240 2.82e-84 257.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1J5QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880 Prenyltransf k59_611786_1 338969.Rfer_3554 2.05e-105 315.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VNZH@28216|Betaproteobacteria,4AC1K@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Dehydrogenase, E1 component bkdA1 - 1.2.4.4 ko:K00166 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,OxoDH_E1alpha_N k59_793522_1 395495.Lcho_4127 6.8e-53 173.0 COG3245@1|root,COG3245@2|Bacteria,1RJCX@1224|Proteobacteria,2VTRB@28216|Betaproteobacteria,1KNNN@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 k59_793522_2 748247.AZKH_0332 1.97e-37 135.0 2CJJV@1|root,30VBX@2|Bacteria,1RGSF@1224|Proteobacteria,2VS5D@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_577302_1 614083.AWQR01000001_gene3094 6.34e-126 364.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,4AC27@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_365391_1 1198452.Jab_2c01080 6.54e-96 300.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_4,PAS_9,Response_reg k59_294491_1 1051985.l11_04500 9.33e-06 52.0 28HDR@1|root,2Z7QA@2|Bacteria,1PXQ9@1224|Proteobacteria,2VNHW@28216|Betaproteobacteria,2KQEF@206351|Neisseriales 206351|Neisseriales - - - - - - - - - - - - - - DUF3102 k59_934309_1 614083.AWQR01000037_gene3473 2.01e-125 367.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VMKY@28216|Betaproteobacteria,4AB49@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Mandelate racemase muconate lactonizing - - 4.2.1.68 ko:K18334 ko00051,ko01120,map00051,map01120 - R03688 RC00543 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_684534_1 477641.MODMU_2619 2.44e-24 99.8 COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4ESKM@85013|Frankiales 201174|Actinobacteria K Regulator lrp_3 - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_1112666_1 1000565.METUNv1_01229 5.99e-88 264.0 COG4340@1|root,COG4340@2|Bacteria,1R9YQ@1224|Proteobacteria,2VHC5@28216|Betaproteobacteria 28216|Betaproteobacteria S 2OG-Fe dioxygenase - - - - - - - - - - - - 2OG-Fe_Oxy_2 k59_332978_1 1223521.BBJX01000007_gene1433 3.12e-122 365.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae 28216|Betaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_793548_1 1267211.KI669560_gene414 5.05e-106 323.0 COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1IPSM@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_149670_3 1000565.METUNv1_02409 2.81e-85 257.0 2E6RE@1|root,331BH@2|Bacteria,1N8K0@1224|Proteobacteria,2VWUF@28216|Betaproteobacteria,2KXGE@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_541912_1 296591.Bpro_0635 7.08e-115 339.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,4ACI6@80864|Comamonadaceae 28216|Betaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp,Epimerase k59_541912_2 296591.Bpro_0641 2.47e-19 85.9 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,4AC93@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_149671_2 987059.RBXJA2T_07818 2.62e-53 168.0 COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,2VSES@28216|Betaproteobacteria,1KM0W@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Belongs to the urease gamma subunit family ureA - 3.5.1.5 ko:K01430 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_gamma k59_43872_1 1173028.ANKO01000093_gene3610 2.18e-15 82.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria 1117|Cyanobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3 k59_400928_1 765910.MARPU_11070 4.18e-42 159.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_970016_1 522306.CAP2UW1_2304 3.14e-64 201.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1KQRA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N k59_970016_2 1000565.METUNv1_01454 6.18e-72 219.0 COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,2VJ22@28216|Betaproteobacteria,2KVWS@206389|Rhodocyclales 206389|Rhodocyclales S Formaldehyde-activating enzyme (Fae) - - 4.2.1.147 ko:K10713 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R08058 RC01583,RC01795 ko00000,ko00001,ko01000 - - - Fae k59_793564_1 640081.Dsui_0016 1.07e-92 278.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,2KV2D@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_970022_1 568768.CM001975_gene765 1.59e-67 225.0 COG2132@1|root,COG2132@2|Bacteria,1PE36@1224|Proteobacteria,1RYCS@1236|Gammaproteobacteria,2JC3C@204037|Dickeya 1236|Gammaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_970034_1 1000565.METUNv1_02896 1.51e-84 265.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUK3@206389|Rhodocyclales 206389|Rhodocyclales NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_114125_2 76114.ebA3372 4.22e-12 62.0 2BX5B@1|root,2ZH3I@2|Bacteria,1PAF6@1224|Proteobacteria,2W6EH@28216|Betaproteobacteria,2KZDI@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_190377_1 1121035.AUCH01000009_gene931 3.14e-75 251.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_365447_1 1000565.METUNv1_03446 9.78e-259 734.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KWW5@206389|Rhodocyclales 206389|Rhodocyclales M AsmA family - - - - - - - - - - - - AsmA k59_970042_2 1123248.KB893319_gene4028 4.03e-29 108.0 COG0779@1|root,COG0779@2|Bacteria,4NQ32@976|Bacteroidetes,1ISSY@117747|Sphingobacteriia 976|Bacteroidetes S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_901106_1 259536.Psyc_0501 1.6e-27 104.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,3NIKY@468|Moraxellaceae 1236|Gammaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_901106_2 1177154.Y5S_03055 3.2e-41 138.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1XKGV@135619|Oceanospirillales 135619|Oceanospirillales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_511726_1 1000565.METUNv1_01903 3.67e-101 311.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_149723_1 1144319.PMI16_02636 2.06e-41 149.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2VRJM@28216|Betaproteobacteria 28216|Betaproteobacteria K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_611853_1 1000565.METUNv1_00615 1.23e-55 181.0 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,2VUIG@28216|Betaproteobacteria,2KX2U@206389|Rhodocyclales 206389|Rhodocyclales S metal-binding, possibly nucleic acid-binding protein - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_1059976_1 543728.Vapar_4393 1.63e-29 110.0 COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,4AE03@80864|Comamonadaceae 28216|Betaproteobacteria S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_1059976_2 1268622.AVS7_03440 2.01e-80 248.0 COG4106@1|root,COG4106@2|Bacteria,1NG56@1224|Proteobacteria,2WGJ8@28216|Betaproteobacteria,4AAHU@80864|Comamonadaceae 28216|Betaproteobacteria S Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_379726_1 378806.STAUR_5234 8.33e-67 212.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2YU88@29|Myxococcales 28221|Deltaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_271878_1 614083.AWQR01000018_gene1803 5.25e-56 183.0 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,4AJXP@80864|Comamonadaceae 28216|Betaproteobacteria S Alpha beta hydrolase fold phaY2 - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_271878_2 614083.AWQR01000018_gene1802 5.1e-71 234.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,4AA2T@80864|Comamonadaceae 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_56600_1 1244869.H261_12879 5.39e-72 247.0 COG0745@1|root,COG4251@1|root,COG5002@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07709,ko:K19694 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HTH_18,HisKA,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y k59_532700_2 626418.bglu_2g12240 7.99e-13 69.3 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VNAJ@28216|Betaproteobacteria,1K2GF@119060|Burkholderiaceae 28216|Betaproteobacteria M RND efflux system, outer membrane lipoprotein, NodT family - - - - - - - - - - - - OEP k59_411831_1 1122951.ATUE01000008_gene88 2.58e-85 270.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,3NJM1@468|Moraxellaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1124218_1 883126.HMPREF9710_01842 1.09e-108 324.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2VJE2@28216|Betaproteobacteria,472EE@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_944955_2 296591.Bpro_1225 9.12e-41 138.0 COG2963@1|root,COG2963@2|Bacteria,1RI5G@1224|Proteobacteria,2VTTM@28216|Betaproteobacteria,4AFER@80864|Comamonadaceae 28216|Betaproteobacteria L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28 k59_842450_2 535289.Dtpsy_0660 1.23e-12 66.2 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,2VQRE@28216|Betaproteobacteria,4ADF7@80864|Comamonadaceae 28216|Betaproteobacteria H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_621502_2 358220.C380_23740 4.01e-51 167.0 COG3154@1|root,COG3154@2|Bacteria,1RB7T@1224|Proteobacteria,2VTWW@28216|Betaproteobacteria,4AENW@80864|Comamonadaceae 28216|Betaproteobacteria I SCP-2 sterol transfer family - - - - - - - - - - - - SCP2 k59_733442_2 748247.AZKH_3288 2.73e-14 75.5 COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2VIAD@28216|Betaproteobacteria,2KV33@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_353927_1 29581.BW37_02670 8.4e-77 251.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,4725S@75682|Oxalobacteraceae 28216|Betaproteobacteria P Putative metal-binding domain of cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_912389_1 1000565.METUNv1_02406 5.72e-68 213.0 COG2165@1|root,COG2165@2|Bacteria,1RHE1@1224|Proteobacteria,2VSJ6@28216|Betaproteobacteria,2KWRU@206389|Rhodocyclales 206389|Rhodocyclales NU general secretion pathway protein - - - - - - - - - - - - N_methyl k59_210044_1 1198452.Jab_1c13450 8.13e-145 424.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,472P4@75682|Oxalobacteraceae 28216|Betaproteobacteria D Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_461150_1 1000565.METUNv1_01102 7.29e-77 233.0 COG0431@1|root,COG0431@2|Bacteria,1MX40@1224|Proteobacteria,2VQFT@28216|Betaproteobacteria,2KX4P@206389|Rhodocyclales 206389|Rhodocyclales S Flavodoxin-like fold - - - - - - - - - - - - FMN_red k59_461162_1 1151127.KB906336_gene1242 6.83e-18 84.3 COG2378@1|root,COG2378@2|Bacteria,1QYA2@1224|Proteobacteria,1RZAX@1236|Gammaproteobacteria,1YR3Q@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K WYL domain mdcH - - - - - - - - - - - WYL k59_91753_1 1000565.METUNv1_02001 4.76e-166 483.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,2KUCJ@206389|Rhodocyclales 206389|Rhodocyclales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_353979_1 1294143.H681_01885 3.25e-43 160.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_877346_1 700598.Niako_6706 7.21e-83 249.0 COG2185@1|root,COG2185@2|Bacteria,4PNV7@976|Bacteroidetes 976|Bacteroidetes I B12 binding domain - - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - B12-binding k59_1124260_1 1109445.AGSX01000141_gene857 1.04e-75 231.0 COG2378@1|root,COG2378@2|Bacteria,1MX81@1224|Proteobacteria,1RMSD@1236|Gammaproteobacteria,1Z33E@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K WYL domain - - - - - - - - - - - - WYL k59_1124260_2 1109445.AGSX01000141_gene856 2.22e-68 209.0 COG0470@1|root,COG0470@2|Bacteria,1R2CD@1224|Proteobacteria,1T5KT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III - - - - - - - - - - - - - k59_1094327_1 869213.JCM21142_83275 1.57e-12 72.8 COG1345@1|root,COG1520@1|root,COG3291@1|root,COG1345@2|Bacteria,COG1520@2|Bacteria,COG3291@2|Bacteria,4NJRF@976|Bacteroidetes,47PMY@768503|Cytophagia 976|Bacteroidetes M domain protein - - - - - - - - - - - - CHU_C,PKD k59_486034_1 1353529.M899_0767 1.63e-47 161.0 COG0745@1|root,COG0745@2|Bacteria,1NSIT@1224|Proteobacteria,42USH@68525|delta/epsilon subdivisions,2WQNN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HisKA,Response_reg k59_91785_1 1000565.METUNv1_02640 2.6e-106 312.0 COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,2VR6V@28216|Betaproteobacteria,2KWP8@206389|Rhodocyclales 206389|Rhodocyclales N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly flgA - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_556022_1 228410.NE0115 2.72e-65 213.0 COG1517@1|root,COG1517@2|Bacteria,1R886@1224|Proteobacteria,2VSBF@28216|Betaproteobacteria,373VD@32003|Nitrosomonadales 28216|Betaproteobacteria L CRISPR-associated (Cas) DxTHG family - - - - - - - - - - - - Cas_DxTHG k59_1094336_1 1448139.AI20_20010 2.28e-30 118.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,1Y3K0@135624|Aeromonadales 135624|Aeromonadales I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_621550_1 1000565.METUNv1_03746 1.13e-101 306.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VP40@28216|Betaproteobacteria,2KUSJ@206389|Rhodocyclales 206389|Rhodocyclales M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_486047_1 1430440.MGMSRv2_0175 1.54e-22 89.7 COG2331@1|root,COG2331@2|Bacteria,1N8DC@1224|Proteobacteria,2UH8G@28211|Alphaproteobacteria,2JUCQ@204441|Rhodospirillales 204441|Rhodospirillales S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_982364_1 1198452.Jab_2c12850 2.18e-29 112.0 COG1843@1|root,COG1843@2|Bacteria,1R4QI@1224|Proteobacteria,2VV60@28216|Betaproteobacteria,4772R@75682|Oxalobacteraceae 28216|Betaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD1 - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgD,FlgD_ig k59_982364_2 1198452.Jab_2c12840 1.23e-43 144.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2WFT2@28216|Betaproteobacteria,478ZM@75682|Oxalobacteraceae 28216|Betaproteobacteria N Flagellar basal body rod FlgEFG protein C-terminal - - - - - - - - - - - - Flg_bb_rod,Flg_bbr_C k59_461248_1 497964.CfE428DRAFT_0788 1.42e-46 162.0 COG0362@1|root,COG0362@2|Bacteria,46SDE@74201|Verrucomicrobia 74201|Verrucomicrobia G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_945025_1 1123257.AUFV01000009_gene2162 4.02e-118 355.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,1X47X@135614|Xanthomonadales 135614|Xanthomonadales L EcoEI R protein C-terminal - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,HSDR_N_2,Helicase_C,ResIII k59_842541_1 1000565.METUNv1_00628 5.68e-165 473.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KUVY@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_842541_2 1000565.METUNv1_00629 2.2e-45 147.0 COG0526@1|root,COG0526@2|Bacteria,1QVC9@1224|Proteobacteria,2VYGG@28216|Betaproteobacteria,2KXAK@206389|Rhodocyclales 206389|Rhodocyclales CO COG0526 Thiol-disulfide isomerase and thioredoxins - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - DUF836 k59_842541_3 1538295.JY96_02460 4.17e-127 378.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,1KJPB@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_461274_1 765869.BDW_04830 6.08e-33 131.0 COG1404@1|root,COG1404@2|Bacteria,1R6X8@1224|Proteobacteria,42ZCV@68525|delta/epsilon subdivisions,2WTVN@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - PA,Peptidase_S8,fn3_5 k59_697014_1 666681.M301_0432 1.96e-37 132.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VSFR@28216|Betaproteobacteria 28216|Betaproteobacteria M Thioredoxin-like - - - - - - - - - - - - Redoxin k59_697014_2 864051.BurJ1DRAFT_2541 9.44e-14 71.6 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_486090_2 1453501.JELR01000001_gene3212 5.5e-51 171.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,464BE@72275|Alteromonadaceae 1236|Gammaproteobacteria CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_877430_1 1000565.METUNv1_03804 9.31e-131 376.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,2KVBM@206389|Rhodocyclales 206389|Rhodocyclales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_56729_1 714943.Mucpa_7099 5.42e-28 114.0 COG0702@1|root,COG0702@2|Bacteria,4PMUE@976|Bacteroidetes 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_56729_2 929713.NIASO_08090 4.14e-27 109.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IV3D@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_556078_2 1000565.METUNv1_03744 3.27e-137 401.0 COG0778@1|root,COG0778@2|Bacteria,1PDX3@1224|Proteobacteria,2VNSD@28216|Betaproteobacteria,2KUNZ@206389|Rhodocyclales 206389|Rhodocyclales C Nitroreductase family moeY - - - - - - - - - - - Nitroreductase k59_912493_2 1000565.METUNv1_02703 9.75e-224 629.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,2KVEZ@206389|Rhodocyclales 28216|Betaproteobacteria M Outer membrane efflux protein oprM - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_733551_1 1304883.KI912532_gene3061 1.42e-64 198.0 2CU7M@1|root,32SUS@2|Bacteria,1N1WF@1224|Proteobacteria,2VUS0@28216|Betaproteobacteria,2KWRI@206389|Rhodocyclales 206389|Rhodocyclales S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_844588_1 506534.Rhein_1575 2.39e-38 144.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria,1WY1F@135613|Chromatiales 135613|Chromatiales I PFAM Acyltransferase - - - - - - - - - - - - Acyl_transf_3 k59_879182_1 1173028.ANKO01000195_gene5985 1.24e-25 108.0 COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,1H8J3@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_9 k59_879182_2 411477.PARMER_00744 8.83e-11 61.6 COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,2FMZE@200643|Bacteroidia,22WC5@171551|Porphyromonadaceae 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_914021_2 1198452.Jab_2c09500 4.42e-46 157.0 COG2984@1|root,COG2984@2|Bacteria,1REID@1224|Proteobacteria,2VZBZ@28216|Betaproteobacteria 1224|Proteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_128974_1 1000565.METUNv1_01484 8.02e-100 309.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_212471_1 1000565.METUNv1_02588 5.69e-134 393.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,2KVHH@206389|Rhodocyclales 206389|Rhodocyclales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_589431_1 1122951.ATUE01000006_gene1499 1.89e-99 313.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,3NJRD@468|Moraxellaceae 1236|Gammaproteobacteria O Belongs to the peptidase S16 family - - - ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_165096_1 1071679.BG57_04740 2.03e-13 77.8 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,MHYT k59_1095451_1 1267211.KI669560_gene883 1.97e-86 278.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,4NF5B@976|Bacteroidetes,1IPW0@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_273827_1 1123248.KB893317_gene4376 6.48e-11 62.4 COG2177@1|root,COG2177@2|Bacteria,4NH05@976|Bacteroidetes 976|Bacteroidetes D Cell division protein FtsX ftsX GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_879218_1 1348657.M622_08785 1.09e-64 219.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KUJG@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_879218_2 640081.Dsui_1964 6.44e-44 143.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,2KWPS@206389|Rhodocyclales 206389|Rhodocyclales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control ihfA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1063001_1 998674.ATTE01000001_gene2320 1.25e-41 149.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,45ZYS@72273|Thiotrichales 72273|Thiotrichales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_382817_1 1523503.JPMY01000046_gene1238 1.39e-28 112.0 COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,1S0U9@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter substrate-binding protein - - - ko:K15553 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.2 - - NMT1 k59_382817_2 1000565.METUNv1_01098 9.42e-20 85.5 COG1116@1|root,COG1116@2|Bacteria,1RAAT@1224|Proteobacteria,2WEFE@28216|Betaproteobacteria 28216|Betaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K15555 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.2 - - ABC_tran k59_93761_1 1100720.ALKN01000031_gene1287 1.48e-111 334.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,4AAIK@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_1063031_1 1123504.JQKD01000021_gene5718 1.7e-41 143.0 COG0559@1|root,COG0559@2|Bacteria,1NWBN@1224|Proteobacteria,2VK48@28216|Betaproteobacteria,4ACAM@80864|Comamonadaceae 28216|Betaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1063031_2 365044.Pnap_2712 6.09e-62 198.0 COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2VMQ5@28216|Betaproteobacteria,4AJ1X@80864|Comamonadaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_212540_1 1144319.PMI16_04323 4.81e-65 218.0 COG1106@1|root,COG1106@2|Bacteria,1R8DC@1224|Proteobacteria,2VY0F@28216|Betaproteobacteria,475A9@75682|Oxalobacteraceae 28216|Betaproteobacteria S AAA ATPase domain - - - - - - - - - - - - AAA_21,AAA_23 k59_1126172_1 365044.Pnap_0805 3.04e-78 243.0 COG3181@1|root,COG3181@2|Bacteria,1Q5FF@1224|Proteobacteria,2VIJ9@28216|Betaproteobacteria,4AAY7@80864|Comamonadaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_589466_1 338969.Rfer_2798 4.07e-120 351.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,4ACNH@80864|Comamonadaceae 28216|Betaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_36533_2 1454004.AW11_03638 2.72e-23 98.6 COG0420@1|root,COG0420@2|Bacteria,1MY4X@1224|Proteobacteria,2VJXS@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM metallophosphoesterase - - - - - - - - - - - - Metallophos k59_786203_1 1000565.METUNv1_02741 0.0 1103.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,2KU9R@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_893150_1 1000565.METUNv1_01443 6.2e-37 136.0 COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,2VMB1@28216|Betaproteobacteria,2KWSN@206389|Rhodocyclales 206389|Rhodocyclales C GXGXG motif - - 1.2.7.12 ko:K00202 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - GXGXG k59_357887_2 1000565.METUNv1_03739 1.85e-162 456.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VQWS@28216|Betaproteobacteria,2KU68@206389|Rhodocyclales 206389|Rhodocyclales V ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_357887_3 1000565.METUNv1_03738 5.69e-138 396.0 COG2834@1|root,COG2834@2|Bacteria,1RE9C@1224|Proteobacteria,2VPGB@28216|Betaproteobacteria,2KVYY@206389|Rhodocyclales 206389|Rhodocyclales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_357887_4 1000565.METUNv1_03737 6.16e-142 404.0 COG3916@1|root,COG3916@2|Bacteria,1RCQC@1224|Proteobacteria,2VQCR@28216|Betaproteobacteria,2KW8K@206389|Rhodocyclales 206389|Rhodocyclales QT Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_357887_5 1458275.AZ34_17580 2.04e-138 399.0 COG3221@1|root,COG3221@2|Bacteria,1PUJG@1224|Proteobacteria,2VKHU@28216|Betaproteobacteria,4AJM3@80864|Comamonadaceae 28216|Betaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_357887_6 690850.Desaf_0834 1.55e-76 275.0 COG0642@1|root,COG1352@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_322376_2 614083.AWQR01000009_gene730 1.2e-106 314.0 28IZ5@1|root,2Z8WP@2|Bacteria,1R6WI@1224|Proteobacteria,2VPVV@28216|Betaproteobacteria,4AC3A@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_643648_1 1000565.METUNv1_00469 1.57e-79 251.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,2KV7J@206389|Rhodocyclales 206389|Rhodocyclales C glycolate oxidase subunit GlcD - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_857231_1 1163408.UU9_00530 1.96e-47 164.0 292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,1X8VI@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_393557_1 1123073.KB899241_gene2828 2.73e-23 97.1 2EIBB@1|root,32TVT@2|Bacteria,1MZJN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_214842_1 1000565.METUNv1_02315 5.51e-31 120.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,2KV76@206389|Rhodocyclales 206389|Rhodocyclales I Long-chain fatty acid transport protein fadL - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_214842_2 1000565.METUNv1_02314 2.62e-53 170.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,2KX58@206389|Rhodocyclales 206389|Rhodocyclales I Thioesterase superfamily - - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_501833_1 748247.AZKH_3739 9.69e-28 105.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,2KX35@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_501833_2 1000565.METUNv1_00120 2.68e-58 183.0 2DMN0@1|root,32SKB@2|Bacteria,1N2XU@1224|Proteobacteria,2VUWF@28216|Betaproteobacteria,2KWXP@206389|Rhodocyclales 206389|Rhodocyclales S HIRAN - - - - - - - - - - - - HIRAN k59_501833_3 1000565.METUNv1_00119 8.12e-25 97.4 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,2KVWJ@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_1072913_1 1231391.AMZF01000094_gene140 2.75e-69 216.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2VPEY@28216|Betaproteobacteria,3T3YP@506|Alcaligenaceae 28216|Betaproteobacteria E threonine efflux protein leuE_1 - - - - - - - - - - - LysE k59_323335_1 1088868.CIN_19630 2.57e-25 107.0 28NWR@1|root,2ZBUJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PDDEXK_4 k59_323335_2 1005395.CSV86_06706 3.12e-87 273.0 COG2378@1|root,COG2378@2|Bacteria,1QYA2@1224|Proteobacteria,1RZAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator mdcH - - - - - - - - - - - WYL k59_822334_1 395494.Galf_2242 5.85e-24 103.0 COG2199@1|root,COG3706@2|Bacteria,1QWCN@1224|Proteobacteria 1224|Proteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_323347_1 1000565.METUNv1_03549 3.04e-131 381.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KV05@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the methyltransferase superfamily - - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_1000814_1 1279038.KB907340_gene1641 3.76e-92 277.0 COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2TRTS@28211|Alphaproteobacteria,2JPRJ@204441|Rhodospirillales 204441|Rhodospirillales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_215430_1 574966.KB898649_gene75 3.89e-90 273.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1XHYS@135619|Oceanospirillales 135619|Oceanospirillales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_37310_1 1000565.METUNv1_01259 4.89e-242 677.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KUE9@206389|Rhodocyclales 206389|Rhodocyclales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,NAD_binding_8 k59_822362_1 1000565.METUNv1_03870 8.58e-92 279.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,2KV6F@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_822362_2 1000565.METUNv1_03869 6.28e-27 107.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KU74@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_679408_1 1472716.KBK24_0101370 5.25e-53 176.0 COG2207@1|root,COG2207@2|Bacteria,1MY46@1224|Proteobacteria,2VKKU@28216|Betaproteobacteria,1K256@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - Cupin_6,HTH_18 k59_679408_2 69293.ENSGACP00000027578 2.8e-11 63.5 KOG2853@1|root,KOG2853@2759|Eukaryota,38ZPZ@33154|Opisthokonta,3B96U@33208|Metazoa,3CXNE@33213|Bilateria,488E7@7711|Chordata,493ZN@7742|Vertebrata,49QTN@7898|Actinopterygii 33208|Metazoa S FAD-dependent oxidoreductase FOXRED1 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009987,GO:0010257,GO:0016020,GO:0016043,GO:0016491,GO:0019866,GO:0022607,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0055114,GO:0065003,GO:0070469,GO:0071840,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 - ko:K18166 - - - - ko00000,ko03029 - - - DAO k59_144165_2 1000565.METUNv1_02811 7.83e-88 292.0 COG4585@1|root,COG4585@2|Bacteria,1R1TC@1224|Proteobacteria,2VHUA@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - 7TMR-DISM_7TM,HATPase_c,HisKA_3 k59_108448_1 375286.mma_1530 1.96e-49 169.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,472K7@75682|Oxalobacteraceae 28216|Betaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_108448_2 1175306.GWL_20510 1.84e-26 102.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,4723Y@75682|Oxalobacteraceae 28216|Betaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1000829_1 1000565.METUNv1_01910 2.14e-97 292.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,2KUFV@206389|Rhodocyclales 206389|Rhodocyclales L A G-specific mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_430382_2 1000565.METUNv1_00992 2.03e-44 150.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria 1224|Proteobacteria K response regulator nreC - - ko:K14979 ko02020,map02020 M00663 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_465524_1 1000565.METUNv1_03995 1.3e-95 293.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,2KUU8@206389|Rhodocyclales 206389|Rhodocyclales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_465524_2 1000565.METUNv1_03994 2.58e-147 418.0 COG0476@1|root,COG0476@2|Bacteria,1RHJV@1224|Proteobacteria,2VTQ0@28216|Betaproteobacteria,2KXDP@206389|Rhodocyclales 206389|Rhodocyclales H Involved in molybdopterin and thiamine biosynthesis, family 2 - - - - - - - - - - - - - k59_465524_3 1000565.METUNv1_03993 1.37e-92 276.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,2KV3M@206389|Rhodocyclales 206389|Rhodocyclales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_323388_1 324057.Pjdr2_2563 0.000104 50.4 COG4447@1|root,COG4733@1|root,COG5297@1|root,COG4447@2|Bacteria,COG4733@2|Bacteria,COG5297@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase family 6 dex - 3.2.1.11 ko:K05988,ko:K06882 ko00500,map00500 - R11309 - ko00000,ko00001,ko01000 - GH66 - fn3 k59_928964_2 388413.ALPR1_00260 4.94e-32 120.0 COG1514@1|root,COG1514@2|Bacteria,4NTUH@976|Bacteroidetes,47RXN@768503|Cytophagia 976|Bacteroidetes J 2'-5' RNA ligase - - - - - - - - - - - - 2_5_RNA_ligase2 k59_572249_1 1000565.METUNv1_00152 1.57e-07 54.3 COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,2KVY0@206389|Rhodocyclales 206389|Rhodocyclales S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_572249_2 640081.Dsui_0329 2.2e-53 199.0 COG0642@1|root,COG3614@1|root,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,2VPUH@28216|Betaproteobacteria,2KW4J@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_4 k59_180535_1 1121904.ARBP01000009_gene4389 2.49e-59 199.0 COG0671@1|root,COG0671@2|Bacteria,4NF9W@976|Bacteroidetes,47JAV@768503|Cytophagia 976|Bacteroidetes I PAP2 superfamily - - - - - - - - - - - - PAP2 k59_893934_2 1000565.METUNv1_00697 1.97e-201 575.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,2KVUA@206389|Rhodocyclales 206389|Rhodocyclales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1036727_1 375286.mma_2682 9.58e-117 346.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2VI7W@28216|Betaproteobacteria,47561@75682|Oxalobacteraceae 28216|Betaproteobacteria L Resolvase, N terminal domain - - - ko:K06400 - - - - ko00000 - - - HTH_7,Recombinase,Resolvase,Zn_ribbon_recom k59_108451_1 1000565.METUNv1_02131 0.0 998.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,2KVA2@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_679417_1 103690.17135081 7.05e-22 103.0 COG1305@1|root,COG1305@2|Bacteria,1FZW2@1117|Cyanobacteria,1HKK2@1161|Nostocales 1117|Cyanobacteria E PFAM Transglutaminase-like superfamily - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_1000833_1 1000565.METUNv1_02934 2.17e-42 142.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,2VREE@28216|Betaproteobacteria,2KWBD@206389|Rhodocyclales 206389|Rhodocyclales O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_1550_1 1175306.GWL_19990 4.47e-05 43.5 COG1396@1|root,COG1396@2|Bacteria,1NEAP@1224|Proteobacteria,2VW7I@28216|Betaproteobacteria 28216|Betaproteobacteria K PFAM helix-turn-helix domain protein - - - ko:K15773 - - - - ko00000,ko02048,ko03000 - - - HTH_3,HTH_31 k59_465535_2 1457393.AZ09_10465 5.8e-76 235.0 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,2TU8N@28211|Alphaproteobacteria,2JXEZ@204441|Rhodospirillales 204441|Rhodospirillales L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_465535_3 587753.EY04_06605 4.37e-25 97.4 2DP7B@1|root,330UW@2|Bacteria,1QVJ5@1224|Proteobacteria,1T4U3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4406) - - - - - - - - - - - - DUF4406 k59_287217_1 1000565.METUNv1_00635 1.18e-128 369.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales 206389|Rhodocyclales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_857831_1 298386.PBPRA0920 1.05e-11 67.0 COG4191@1|root,COG4191@2|Bacteria,1QUWB@1224|Proteobacteria,1T23G@1236|Gammaproteobacteria,1Y35M@135623|Vibrionales 135623|Vibrionales T PAS domain - - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_8 k59_857831_2 748247.AZKH_4429 2.43e-24 104.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2VHR0@28216|Betaproteobacteria,2KVR2@206389|Rhodocyclales 206389|Rhodocyclales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_72632_1 932677.PAJ_0934 6.75e-110 349.0 COG0846@1|root,COG0846@2|Bacteria,1Q89F@1224|Proteobacteria,1RRI4@1236|Gammaproteobacteria 1236|Gammaproteobacteria K SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_1073014_1 1237149.C900_05555 4.45e-87 260.0 COG4894@1|root,COG4894@2|Bacteria,4NK2I@976|Bacteroidetes,47VBX@768503|Cytophagia 976|Bacteroidetes S Scramblase - - - - - - - - - - - - Scramblase k59_1107844_2 748247.AZKH_3810 4.79e-132 381.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2VJ8T@28216|Betaproteobacteria,2KURE@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S - - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_1107844_3 1131553.JIBI01000003_gene1687 1e-15 71.2 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2VVVB@28216|Betaproteobacteria,373ME@32003|Nitrosomonadales 28216|Betaproteobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1107844_4 1000565.METUNv1_01992 7.59e-06 47.4 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VNSK@28216|Betaproteobacteria,2KY16@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - Radical_SAM k59_964991_1 1157708.KB907451_gene4751 2.99e-44 150.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,4A9ZR@80864|Comamonadaceae 28216|Betaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_964991_2 296591.Bpro_4862 1.07e-49 171.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,4AAUW@80864|Comamonadaceae 28216|Betaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_251518_2 1000565.METUNv1_00264 5.93e-109 320.0 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,2KWVV@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_644689_2 261292.Nit79A3_1404 6.35e-16 82.0 COG3355@1|root,COG3355@2|Bacteria,1N3ME@1224|Proteobacteria,2VTXQ@28216|Betaproteobacteria 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - - k59_644689_4 398578.Daci_1933 2.08e-70 229.0 COG0305@1|root,COG0305@2|Bacteria,1PP51@1224|Proteobacteria,2VQ9Z@28216|Betaproteobacteria 28216|Betaproteobacteria L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C k59_644689_9 1380387.JADM01000008_gene954 8.86e-32 118.0 COG1403@1|root,COG1403@2|Bacteria,1RIBS@1224|Proteobacteria,1S88N@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Bacteriophage Lambda NinG protein - - - - - - - - - - - - NinG k59_679433_1 1000565.METUNv1_01929 3.52e-13 68.9 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,2KUJD@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_679433_2 1000565.METUNv1_01930 1.22e-137 414.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KYB2@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9,Response_reg k59_1073024_1 1121033.AUCF01000001_gene2234 7.75e-14 70.9 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,2JQ5V@204441|Rhodospirillales 204441|Rhodospirillales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1036758_1 1000565.METUNv1_02671 1.75e-177 503.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2WGGJ@28216|Betaproteobacteria,2KUT8@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_287238_1 984262.SGRA_0564 2.04e-43 153.0 COG0196@1|root,COG0196@2|Bacteria,4NEI9@976|Bacteroidetes 976|Bacteroidetes H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_394359_1 990285.RGCCGE502_20970 1.83e-34 136.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,4BNVY@82115|Rhizobiaceae 28211|Alphaproteobacteria T Multi-sensor signal transduction multi-kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Pkinase k59_928994_1 76114.ebA4105 1.1e-67 213.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,2KW4Z@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_144198_1 1000565.METUNv1_03336 6.26e-236 661.0 COG1112@1|root,COG1112@2|Bacteria,1QVD2@1224|Proteobacteria,2WGQZ@28216|Betaproteobacteria,2KVRA@206389|Rhodocyclales 206389|Rhodocyclales L UvrD-like helicase C-terminal domain - - - - - - - - - - - - UvrD_C_2 k59_1000856_1 1000565.METUNv1_00803 1.15e-255 725.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales 206389|Rhodocyclales CM Acyl-CoA synthetase (NDP forming) yfiQ - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_394364_1 1000565.METUNv1_01798 2.96e-94 283.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VM1S@28216|Betaproteobacteria,2KY39@206389|Rhodocyclales 206389|Rhodocyclales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_715657_1 1449355.JQNR01000005_gene4138 4.49e-07 52.4 COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria 201174|Actinobacteria L DNA helicase uvrD2 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - HRDC,UvrD-helicase,UvrD_C k59_868405_1 557598.LHK_01539 4.72e-171 496.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,2VU8A@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_11948_1 1000565.METUNv1_03665 1.89e-93 281.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,2KUXF@206389|Rhodocyclales 206389|Rhodocyclales GM epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_340328_1 1000565.METUNv1_03224 5.48e-112 325.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2VI8M@28216|Betaproteobacteria,2KV5F@206389|Rhodocyclales 28216|Betaproteobacteria C Prokaryotic cytochrome b561 hoxZ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_340328_2 1000565.METUNv1_03225 7.51e-10 57.4 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2VTYR@28216|Betaproteobacteria,2KXCK@206389|Rhodocyclales 206389|Rhodocyclales O HupE UreJ protein - - - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_546538_1 1000565.METUNv1_02619 6.14e-126 364.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria,2KV3U@206389|Rhodocyclales 206389|Rhodocyclales T Chemotaxis signal transduction protein - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_664791_1 926554.KI912633_gene3825 0.00028 48.5 COG0477@1|root,COG0477@2|Bacteria,1WIBD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus EGP TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - - - - - - - - - - MFS_1 k59_84791_1 1223521.BBJX01000001_gene819 2.47e-42 146.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VIN2@28216|Betaproteobacteria,4ACQ7@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component dppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_84791_2 296591.Bpro_2113 4.83e-52 177.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,4ABBW@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_372329_1 1340493.JNIF01000003_gene1752 7.59e-15 79.3 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_120057_1 471854.Dfer_3908 1.99e-22 93.6 COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,47KA2@768503|Cytophagia 976|Bacteroidetes G pfkB family carbohydrate kinase ydjH - - - - - - - - - - - PfkB k59_342626_1 587753.EY04_26385 4.18e-64 205.0 COG2207@1|root,COG2207@2|Bacteria,1P23G@1224|Proteobacteria,1RZQ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - AraC_binding,HTH_18 k59_200045_1 697282.Mettu_1649 1.56e-66 225.0 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,1RNBT@1236|Gammaproteobacteria,1XDXH@135618|Methylococcales 135618|Methylococcales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_478038_1 1157708.KB907463_gene848 3.12e-111 322.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,4A9NQ@80864|Comamonadaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_906341_1 468059.AUHA01000003_gene1816 1.27e-54 192.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1IUT7@117747|Sphingobacteriia 976|Bacteroidetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_664885_1 1121904.ARBP01000028_gene1710 7.76e-67 218.0 COG0673@1|root,COG0673@2|Bacteria,4NIF1@976|Bacteroidetes,47JIW@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_547994_1 1123257.AUFV01000003_gene844 1.43e-68 224.0 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1X57A@135614|Xanthomonadales 135614|Xanthomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_547994_2 1318628.MARLIPOL_16844 9.34e-19 87.8 COG2207@1|root,COG2207@2|Bacteria,1R7PM@1224|Proteobacteria,1RYYY@1236|Gammaproteobacteria,46CNV@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_450521_1 1144319.PMI16_03103 2.25e-81 250.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,472H0@75682|Oxalobacteraceae 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1118218_1 1000565.METUNv1_03363 3.13e-10 60.5 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KUKS@206389|Rhodocyclales 206389|Rhodocyclales IQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase k59_1118218_2 1123487.KB892838_gene3901 1.66e-40 146.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VK3J@28216|Betaproteobacteria,2KVS1@206389|Rhodocyclales 206389|Rhodocyclales E Diaminopimelate decarboxylase - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_939367_1 644801.Psest_4048 5.33e-145 424.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,1Z2PY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_727234_1 1280944.HY17_17710 3.87e-44 170.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria 1224|Proteobacteria U 6-phosphogluconolactonase activity - - - - - - - - - - - - Cadherin,DUF4347,Haemagg_act,He_PIG,Hint_2,TIG k59_690167_1 338969.Rfer_1968 3.89e-96 289.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,4AB6A@80864|Comamonadaceae 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_690167_2 535289.Dtpsy_2580 9.08e-34 126.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,4AA4G@80864|Comamonadaceae 28216|Betaproteobacteria J RNA-metabolising metallo-beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_224524_1 1000565.METUNv1_02707 1.71e-72 233.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,2KV9K@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_906370_1 421531.IX38_20975 1.75e-43 150.0 COG1562@1|root,COG1562@2|Bacteria,4NEIK@976|Bacteroidetes,1HXBH@117743|Flavobacteriia,3ZPWG@59732|Chryseobacterium 976|Bacteroidetes I Phytoene synthase crtB - - - - - - - - - - - SQS_PSY k59_906370_2 1296415.JACC01000037_gene1066 0.000408 44.7 2C56J@1|root,32YX8@2|Bacteria,4NW78@976|Bacteroidetes,1I574@117743|Flavobacteriia,2YJH7@290174|Aquimarina 976|Bacteroidetes - - - - - - - - - - - - - - - k59_49829_1 1454007.JAUG01000016_gene1762 1.03e-20 89.0 COG0039@1|root,COG0039@2|Bacteria,4NEJ7@976|Bacteroidetes,1IP11@117747|Sphingobacteriia 976|Bacteroidetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_49829_2 929703.KE386491_gene657 2.38e-56 187.0 COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,47J9P@768503|Cytophagia 976|Bacteroidetes V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_835263_2 614083.AWQR01000009_gene728 7.79e-49 158.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,4AEEK@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_835263_3 543728.Vapar_5172 5.09e-18 78.2 COG3313@1|root,COG3313@2|Bacteria,1N711@1224|Proteobacteria,2VW2B@28216|Betaproteobacteria,4AE63@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3717) - - - ko:K06938 - - - - ko00000 - - - DUF1289,DUF3717 k59_224541_2 1538644.KO02_11885 9.11e-31 114.0 COG0742@1|root,COG0742@2|Bacteria,4NM7J@976|Bacteroidetes,1ISB1@117747|Sphingobacteriia 976|Bacteroidetes L RNA methyltransferase, RsmD rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_1049306_1 205922.Pfl01_5542 1.95e-16 79.7 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria 1236|Gammaproteobacteria G phosphomannomutase algC GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_521547_1 1122951.ATUE01000006_gene1224 5.3e-82 266.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,3NJRI@468|Moraxellaceae 1236|Gammaproteobacteria D Ftsk_gamma ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_156472_1 492774.JQMB01000010_gene4683 1.02e-35 124.0 COG3832@1|root,COG3832@2|Bacteria,1RA7N@1224|Proteobacteria,2U5AM@28211|Alphaproteobacteria,4BED6@82115|Rhizobiaceae 28211|Alphaproteobacteria S Polyketide cyclase / dehydrase and lipid transport MA20_01005 - - - - - - - - - - - AHSA1 k59_156472_2 1229205.BUPH_06532 4.42e-44 146.0 COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2VRM6@28216|Betaproteobacteria,1K7V2@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_84882_1 338969.Rfer_2524 1.9e-13 71.2 COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria,4AE3D@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_17 k59_84882_2 1265502.KB905931_gene1643 1.67e-23 94.4 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,2VWT7@28216|Betaproteobacteria,4AFCN@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_372434_1 398578.Daci_3047 1.15e-57 184.0 28PUY@1|root,2ZCFT@2|Bacteria,1RBXF@1224|Proteobacteria,2VQKA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_478140_1 1366050.N234_11885 1.19e-58 192.0 COG0834@1|root,COG0834@2|Bacteria,1RIGN@1224|Proteobacteria,2VMMR@28216|Betaproteobacteria,1KCTD@119060|Burkholderiaceae 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_478142_1 1229205.BUPH_00244 6.21e-38 137.0 COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,1K2SA@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k59_521580_1 883126.HMPREF9710_03106 2.2e-88 270.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,472HW@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_13495_1 795666.MW7_2951 1.76e-69 233.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,1K084@119060|Burkholderiaceae 28216|Betaproteobacteria L helicase - - - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - DUF3883,Helicase_C,SNF2_N k59_13495_2 795666.MW7_2950 6.53e-16 76.3 COG1002@1|root,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,2VPJC@28216|Betaproteobacteria,1K5G8@119060|Burkholderiaceae 28216|Betaproteobacteria V Pfam:Methyltransf_26 - - - - - - - - - - - - - k59_200198_1 1198452.Jab_1c05730 2.08e-62 202.0 COG3203@1|root,COG3203@2|Bacteria,1R6MS@1224|Proteobacteria,2VMAA@28216|Betaproteobacteria,475YN@75682|Oxalobacteraceae 28216|Betaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_405875_1 748247.AZKH_p0143 2.83e-100 298.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,2KUYY@206389|Rhodocyclales 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_870044_1 1000565.METUNv1_02457 8.85e-120 357.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KVJ8@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - FHA,GAF,HD,HD_5 k59_84903_1 1177179.A11A3_02567 3.2e-92 286.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XH53@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.10.3.10,1.9.3.1 ko:K02274,ko:K02298 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 k59_84903_2 458817.Shal_0258 9.29e-16 77.4 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,2Q8ZR@267890|Shewanellaceae 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_582173_1 467661.RKLH11_3695 2.86e-33 127.0 COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,2TYR6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_521616_1 1265502.KB905949_gene934 5.82e-87 258.0 COG3772@1|root,COG3772@2|Bacteria,1PPSW@1224|Proteobacteria,2VQJH@28216|Betaproteobacteria,4ADKR@80864|Comamonadaceae 28216|Betaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_582177_1 335283.Neut_2059 1.4e-20 89.4 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2VIU6@28216|Betaproteobacteria,372YU@32003|Nitrosomonadales 28216|Betaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_582177_2 1000565.METUNv1_02757 7.99e-40 135.0 COG3190@1|root,COG3190@2|Bacteria,1PQ30@1224|Proteobacteria,2VWHP@28216|Betaproteobacteria,2KX1R@206389|Rhodocyclales 206389|Rhodocyclales N flagellar fliO - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO k59_939432_1 45157.CMW023CT 2.58e-31 126.0 COG1008@1|root,KOG4845@2759|Eukaryota 2759|Eukaryota C NADH dehydrogenase (quinone) activity nad4 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464 1.6.5.3 ko:K03881 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - Proton_antipo_M k59_835308_1 365046.Rta_17280 1.89e-82 258.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,4A9M8@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase HAMP region domain protein risS - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,RisS_PPD k59_224583_1 338969.Rfer_3545 2.25e-87 270.0 COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,2VPDJ@28216|Betaproteobacteria,4ACR2@80864|Comamonadaceae 28216|Betaproteobacteria S PGAP1-like protein - - - - - - - - - - - - PGAP1 k59_548113_1 640081.Dsui_2797 3.9e-91 286.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,2KUQ6@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_13525_1 1353529.M899_0739 4.59e-58 196.0 COG1816@1|root,COG1816@2|Bacteria,1R7EK@1224|Proteobacteria,42MHV@68525|delta/epsilon subdivisions,2MSQX@213481|Bdellovibrionales,2WMI4@28221|Deltaproteobacteria 213481|Bdellovibrionales F Adenosine/AMP deaminase - - - - - - - - - - - - A_deaminase k59_727311_1 1000565.METUNv1_00278 2.19e-89 273.0 COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,1N4K5@1224|Proteobacteria,2VKGP@28216|Betaproteobacteria,2KVU6@206389|Rhodocyclales 206389|Rhodocyclales T Sigma factor PP2C-like phosphatases - - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_301295_1 305700.B447_07242 1.42e-247 683.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,2KUZG@206389|Rhodocyclales 206389|Rhodocyclales C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_264597_1 998088.B565_1189 1.32e-36 144.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQCU@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB evgS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07677,ko:K07679 ko02020,ko02026,ko05133,map02020,map02026,map05133 M00474,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg,SBP_bac_3 k59_975642_2 1000565.METUNv1_03588 4.97e-66 203.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,2VTZE@28216|Betaproteobacteria,2KWTP@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0225 family - - - ko:K09858 - - - - ko00000 - - - SEC-C k59_342869_1 1064537.AGSO01000001_gene684 5.17e-46 168.0 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4FDKF@85020|Dermabacteraceae 201174|Actinobacteria S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_84931_1 768671.ThimaDRAFT_0437 0.000399 47.4 COG1216@1|root,COG1216@2|Bacteria,1RB30@1224|Proteobacteria,1RPV7@1236|Gammaproteobacteria,1X0ZJ@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_478199_1 189753.AXAS01000001_gene3779 4.82e-86 271.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,3JQYV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G ABC transporter - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran k59_835333_1 1538295.JY96_19780 9.38e-96 294.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,1KK4U@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Poly-beta-hydroxybutyrate polymerase phbC2 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_870093_1 159087.Daro_3274 4.6e-222 623.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,2KUGA@206389|Rhodocyclales 206389|Rhodocyclales C COG2010 Cytochrome c, mono- and diheme variants - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_224616_1 1123399.AQVE01000006_gene3595 1.1e-21 95.5 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,460IP@72273|Thiotrichales 72273|Thiotrichales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_224616_2 911045.PSE_0855 1.57e-13 73.2 2DT0V@1|root,33I77@2|Bacteria,1NK6B@1224|Proteobacteria,2UM7W@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_342903_1 1134474.O59_001465 2.16e-20 88.6 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1FGC4@10|Cellvibrio 1236|Gammaproteobacteria S HAD-hyrolase-like gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_342903_2 454957.IA64_09215 1.8e-28 113.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1X407@135614|Xanthomonadales 135614|Xanthomonadales J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_616359_1 1123242.JH636436_gene254 1.56e-24 101.0 COG4102@1|root,COG4102@2|Bacteria,2IXKR@203682|Planctomycetes 203682|Planctomycetes T Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_342914_1 1223521.BBJX01000002_gene2856 4.09e-154 444.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VHBI@28216|Betaproteobacteria,4AGVV@80864|Comamonadaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_494849_1 365044.Pnap_2051 3.55e-82 254.0 COG1216@1|root,COG1216@2|Bacteria,1QV95@1224|Proteobacteria,2VQ6S@28216|Betaproteobacteria,4AGKQ@80864|Comamonadaceae 28216|Betaproteobacteria S N-terminal domain of galactosyltransferase - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_494849_2 365046.Rta_21070 2.18e-18 84.3 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,4A9JN@80864|Comamonadaceae 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_989680_1 929703.KE386491_gene3357 3.84e-67 217.0 COG4992@1|root,COG4992@2|Bacteria,4NE93@976|Bacteroidetes,47K80@768503|Cytophagia 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_851168_1 1276756.AUEX01000004_gene2507 2.28e-135 391.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,4AAIT@80864|Comamonadaceae 28216|Betaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1028650_1 1265505.ATUG01000002_gene2699 6.48e-19 88.6 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,42Y3Q@68525|delta/epsilon subdivisions,2WT53@28221|Deltaproteobacteria,2MNSV@213118|Desulfobacterales 28221|Deltaproteobacteria T Forkhead associated domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_494908_1 366649.XFF4834R_chr21380 1.91e-69 222.0 COG2207@1|root,COG2207@2|Bacteria,1R7G3@1224|Proteobacteria,1S1SV@1236|Gammaproteobacteria,1X5G6@135614|Xanthomonadales 135614|Xanthomonadales K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_918924_1 365046.Rta_17380 7.71e-76 248.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,4AACP@80864|Comamonadaceae 28216|Betaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_418498_1 614083.AWQR01000043_gene3510 1.13e-122 358.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria,4AB7B@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add - 3.5.4.2,3.5.4.4 ko:K01488,ko:K21053 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01244,R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_594240_1 1205683.CAKR01000030_gene4216 1.38e-44 151.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,41D8N@629|Yersinia 1236|Gammaproteobacteria S Stringent starvation protein B sspB GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_594240_2 575589.HMPREF0018_01267 1.78e-38 139.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,3NJ6U@468|Moraxellaceae 1236|Gammaproteobacteria S BON domain yraP GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944 - - - - - - - - - - BON k59_704340_1 640081.Dsui_1270 6.96e-141 413.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KUHV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_594245_1 1122603.ATVI01000007_gene1462 2.77e-99 300.0 COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,1RPWG@1236|Gammaproteobacteria,1X3FE@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF445 k59_772940_1 375286.mma_2198 5.12e-73 237.0 28QU5@1|root,2ZD9H@2|Bacteria,1RAU8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_772940_5 347834.RHE_CH01097 8.58e-132 382.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria,4B747@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_813587_1 395965.Msil_2916 2.88e-25 97.4 COG0639@1|root,COG0639@2|Bacteria,1N2CE@1224|Proteobacteria,2U9HP@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Domain of unknown function DUF29 - - - - - - - - - - - - DUF29 k59_813587_2 1121033.AUCF01000003_gene3430 9.03e-52 182.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2JPGY@204441|Rhodospirillales 204441|Rhodospirillales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1131777_1 1000565.METUNv1_02302 1.91e-40 147.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,2KUDC@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_391168_1 1286631.X805_18740 5.29e-05 45.4 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1KISW@119065|unclassified Burkholderiales 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_391168_2 358220.C380_04335 3.11e-82 256.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,4A9SB@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1098973_1 1000565.METUNv1_02366 1.81e-99 301.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,2KV4V@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_740380_1 614083.AWQR01000020_gene180 3.67e-69 230.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4AARD@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_772958_1 232721.Ajs_4047 2.55e-125 365.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,4AA82@80864|Comamonadaceae 28216|Betaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_391202_1 292415.Tbd_1781 1.61e-87 270.0 COG0438@1|root,COG0438@2|Bacteria,1MUYN@1224|Proteobacteria,2VNWP@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase - - - - - - - - - - - - DUF1972,Glyco_trans_1_2,Glyco_transf_4,Glycos_transf_1 k59_918977_1 582402.Hbal_2163 2.34e-07 52.4 COG2172@1|root,COG2199@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria,43ZGA@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Stage II sporulation E family protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE k59_564458_1 864073.HFRIS_020561 1.5e-79 240.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,4729Z@75682|Oxalobacteraceae 28216|Betaproteobacteria O C-terminal domain of 1-Cys peroxiredoxin lsfA - - - - - - - - - - - 1-cysPrx_C,AhpC-TSA k59_564458_2 1005048.CFU_1141 2.33e-36 135.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,2VINN@28216|Betaproteobacteria,4728M@75682|Oxalobacteraceae 28216|Betaproteobacteria L Exonuclease C-terminal sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_951262_1 994479.GL877878_gene902 2.47e-09 62.0 COG0784@1|root,COG1511@1|root,COG4251@1|root,COG0784@2|Bacteria,COG1511@2|Bacteria,COG4251@2|Bacteria,2I7BV@201174|Actinobacteria 201174|Actinobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - - k59_418569_1 1278073.MYSTI_01271 3.37e-45 158.0 COG2378@1|root,COG2378@2|Bacteria,1R98A@1224|Proteobacteria,42VBY@68525|delta/epsilon subdivisions,2WRWU@28221|Deltaproteobacteria,2YU1N@29|Myxococcales 28221|Deltaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_495015_1 1217715.F994_01735 2.26e-12 72.0 COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,1SYDP@1236|Gammaproteobacteria,3NTBG@468|Moraxellaceae 1236|Gammaproteobacteria CH FAD binding domain mhpA GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0019439,GO:0019622,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046395,GO:0046435,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_0329 FAD_binding_3 k59_418571_2 1286631.X805_38330 4.93e-06 47.4 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,1KKZ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_627125_1 1417599.U6C855_9CAUD 1.24e-35 140.0 4QCM6@10239|Viruses,4QVAQ@35237|dsDNA viruses no RNA stage,4QPVV@28883|Caudovirales,4QNID@10744|Podoviridae 10744|Podoviridae S actin binding - - - - - - - - - - - - - k59_495028_1 1120999.JONM01000014_gene2886 1.25e-12 70.9 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,2KPX5@206351|Neisseriales 206351|Neisseriales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_495028_2 998088.B565_1720 1.19e-17 76.6 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1Y4H5@135624|Aeromonadales 135624|Aeromonadales L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_63711_1 887062.HGR_13239 2.8e-85 273.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_63711_2 358220.C380_06695 0.000116 44.7 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,4ABB5@80864|Comamonadaceae 28216|Betaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_1131856_1 614083.AWQR01000009_gene696 1.21e-43 160.0 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,4AC9D@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_1131856_2 365046.Rta_36960 6e-50 167.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,4A9SD@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_851300_1 1395516.PMO01_09275 4.06e-23 105.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M RND efflux system, outer membrane lipoprotein opmQ - - - - - - - - - - - OEP k59_854589_1 882378.RBRH_01213 2.3e-91 281.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2VM59@28216|Betaproteobacteria,1KFBP@119060|Burkholderiaceae 28216|Betaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_174219_1 1127673.GLIP_0761 1.1e-23 102.0 COG1538@1|root,COG1538@2|Bacteria,1MUHM@1224|Proteobacteria,1RNNS@1236|Gammaproteobacteria,469JV@72275|Alteromonadaceae 1236|Gammaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_239210_1 365046.Rta_12100 1.96e-41 137.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria,4AF0Y@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_239210_2 358220.C380_06770 7.98e-36 127.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,4ADPE@80864|Comamonadaceae 28216|Betaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_992285_1 331869.BAL199_12696 3.03e-07 53.5 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_103036_2 857087.Metme_2779 1.7e-10 61.6 COG4278@1|root,COG4278@2|Bacteria,1RBTS@1224|Proteobacteria,1S5B5@1236|Gammaproteobacteria 1236|Gammaproteobacteria H phenylacetate-CoA ligase activity - - - - - - - - - - - - - k59_629009_1 1000565.METUNv1_00893 5.27e-62 201.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria 28216|Betaproteobacteria C eight transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_706934_1 748280.NH8B_3497 5.68e-39 143.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KPNP@206351|Neisseriales 206351|Neisseriales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_706934_2 159087.Daro_0938 3.93e-28 110.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_629015_1 1027273.GZ77_17900 2.92e-05 45.8 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XHXZ@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_629015_2 83406.HDN1F_35960 9.95e-56 182.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1J4YW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_174247_1 553385.JEMF01000019_gene1077 1.14e-38 144.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1XIFP@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta,DNA_pol3_gamma3 k59_103068_1 358220.C380_07445 1.83e-103 308.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,4AAJE@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_66513_1 1122951.ATUE01000009_gene441 1.4e-39 136.0 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria,3NJ55@468|Moraxellaceae 1236|Gammaproteobacteria G Peptidyl-prolyl cis-trans fkpB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_66513_2 1120977.JHUX01000007_gene161 3.93e-25 98.6 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,3NJUG@468|Moraxellaceae 1236|Gammaproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_174292_1 1380391.JIAS01000011_gene4840 1.3e-22 96.7 COG0834@1|root,COG0834@2|Bacteria,1N536@1224|Proteobacteria,2UFMZ@28211|Alphaproteobacteria,2JY9S@204441|Rhodospirillales 204441|Rhodospirillales ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_775846_1 1123257.AUFV01000009_gene2161 7.97e-91 281.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria,1X515@135614|Xanthomonadales 135614|Xanthomonadales V Type I restriction-modification system methyltransferase subunit - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_775846_2 1123257.AUFV01000009_gene2162 1.27e-135 403.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,1X47X@135614|Xanthomonadales 135614|Xanthomonadales L EcoEI R protein C-terminal - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,HSDR_N_2,Helicase_C,ResIII k59_282242_1 1122605.KB893639_gene3044 8.17e-19 85.5 COG4102@1|root,COG4102@2|Bacteria,4NE73@976|Bacteroidetes,1IQYR@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_498766_1 1121904.ARBP01000001_gene5928 5.42e-73 245.0 COG1181@1|root,COG1181@2|Bacteria,4NE9P@976|Bacteroidetes,47M8U@768503|Cytophagia 976|Bacteroidetes F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_854686_1 342113.DM82_3203 4.18e-50 171.0 COG2207@1|root,COG2207@2|Bacteria,1MXT9@1224|Proteobacteria,2VK2J@28216|Betaproteobacteria,1K9MG@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_1032061_1 1122951.ATUE01000008_gene127 2.9e-168 482.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,3NIRX@468|Moraxellaceae 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_30221_1 1000565.METUNv1_01557 7.5e-71 237.0 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2VNYP@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 k59_421358_2 358220.C380_23130 4.33e-95 290.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae 28216|Betaproteobacteria S FAD dependent oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_921687_1 553171.HMPREF0648_1043 5.69e-20 95.1 28I3N@1|root,2Z87C@2|Bacteria,4NE8P@976|Bacteroidetes,2FMN4@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - DUF4105 k59_629068_1 1198452.Jab_2c29080 2.68e-31 117.0 COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2VJ3H@28216|Betaproteobacteria,473V9@75682|Oxalobacteraceae 28216|Betaproteobacteria U ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - ko:K02050,ko:K15554 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - BPD_transp_1 k59_629068_2 1198452.Jab_2c29090 2.5e-33 123.0 COG0715@1|root,COG0715@2|Bacteria,1PDWW@1224|Proteobacteria,2VIDB@28216|Betaproteobacteria,473MR@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051,ko:K15553 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - NMT1,NMT1_2 k59_890203_1 6500.XP_005106506.1 9.23e-28 116.0 COG0553@1|root,KOG1000@2759|Eukaryota,38C05@33154|Opisthokonta,3BE0M@33208|Metazoa,3CT9F@33213|Bilateria 33208|Metazoa B SWI SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein ZRANB3 GO:0000018,GO:0000228,GO:0000733,GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006275,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017111,GO:0019219,GO:0019222,GO:0031297,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031593,GO:0031974,GO:0031981,GO:0032392,GO:0033554,GO:0034641,GO:0034645,GO:0036292,GO:0036310,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045005,GO:0045910,GO:0045934,GO:0046483,GO:0048478,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070013,GO:0070530,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090329,GO:0097159,GO:0097617,GO:0140030,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - - - - - - - - - - HNH,Helicase_C,SNF2_N,zf-RanBP k59_103158_1 1121920.AUAU01000018_gene1819 8.44e-26 103.0 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein damX - - ko:K03112 - - - - ko00000 - - - AAA_10,SPOR k59_103158_2 1121920.AUAU01000018_gene1820 1.29e-39 133.0 28S5K@1|root,2ZEH5@2|Bacteria 2|Bacteria S Protein of unknown function (FYDLN_acid) - - - - - - - - - - - - FYDLN_acid k59_239329_1 338969.Rfer_0056 6.06e-62 204.0 2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae 28216|Betaproteobacteria M Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 k59_596805_1 189753.AXAS01000086_gene6889 1.17e-25 100.0 COG2197@1|root,COG2197@2|Bacteria,1QWT4@1224|Proteobacteria,2VF57@28211|Alphaproteobacteria,3JWZ4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_896335_1 557598.LHK_01552 1.47e-16 84.3 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2VRGU@28216|Betaproteobacteria,2KR8T@206351|Neisseriales 206351|Neisseriales S Glycosyl hydrolase 108 - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_896335_2 557598.LHK_01551 1.3e-31 119.0 2DU3B@1|root,33NS9@2|Bacteria,1NMEE@1224|Proteobacteria,2W35U@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_396806_1 1122951.ATUE01000008_gene47 1.15e-33 124.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271,ko:K12961 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005,ko03036 - - - SIS_2 k59_396806_2 641491.DND132_2708 3.04e-14 72.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MCFG@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_360938_1 1123366.TH3_02150 3.57e-109 328.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2TUN4@28211|Alphaproteobacteria,2JQ1R@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_609229_1 1283284.AZUK01000001_gene816 2.84e-75 235.0 COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,1RQPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Spermidine putrescine ABC transporter substrate-binding protein ydcS GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576 - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - iECNA114_1301.ECNA114_1576,iECSF_1327.ECSF_1364,iEcHS_1320.EcHS_A1524 SBP_bac_8 k59_896338_1 1122951.ATUE01000006_gene1154 2.8e-129 387.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,3NIJ5@468|Moraxellaceae 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0000166,GO:0000900,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004829,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006435,GO:0006446,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0017076,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0030371,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032553,GO:0032555,GO:0032559,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045947,GO:0046483,GO:0046872,GO:0046914,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097367,GO:0106074,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iPC815.YPO2433,iSDY_1059.SDY_1814 HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_896338_2 998674.ATTE01000001_gene2807 3.56e-16 75.1 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,460MP@72273|Thiotrichales 72273|Thiotrichales J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_717775_1 1000565.METUNv1_00666 1.01e-28 109.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,2KUHC@206389|Rhodocyclales 206389|Rhodocyclales I Squalene synthase HpnD - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_717775_2 1000565.METUNv1_00667 1.46e-67 212.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,2KUC0@206389|Rhodocyclales 206389|Rhodocyclales I phytoene - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_1002744_1 1000565.METUNv1_01139 1.5e-67 212.0 COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,2VI7P@28216|Betaproteobacteria,2KUFI@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_254684_2 160488.PP_2987 2.77e-95 280.0 COG1733@1|root,COG1733@2|Bacteria,1RJES@1224|Proteobacteria,1S811@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HxlR k59_539153_1 1000565.METUNv1_01290 3.19e-27 107.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,2KVNR@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_539153_2 497321.C664_00265 5.41e-53 173.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,2KWH8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_539153_3 1000565.METUNv1_01292 5.23e-162 476.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_111027_1 760117.JN27_19180 3.21e-28 117.0 290AK@1|root,2ZN06@2|Bacteria,1P4U2@1224|Proteobacteria,2WA82@28216|Betaproteobacteria,475YH@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1110177_1 1000565.METUNv1_02796 1.7e-77 246.0 COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,2KUQ6@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_860282_1 543728.Vapar_1270 1.56e-95 280.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,4AB9G@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_649091_1 159087.Daro_3181 1.34e-32 118.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,2KUMW@206389|Rhodocyclales 206389|Rhodocyclales E Hydrolase - - - - - - - - - - - - HAD k59_649091_2 1000565.METUNv1_01884 2.78e-134 384.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,2KWRT@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the DnaA family - - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_184756_1 1000565.METUNv1_00464 8.92e-68 223.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KUWX@206389|Rhodocyclales 206389|Rhodocyclales I Poly(R)-hydroxyalkanoic acid synthase, class I - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_184756_2 1000565.METUNv1_00463 2.66e-30 109.0 2E3TT@1|root,32YR7@2|Bacteria,1N9R9@1224|Proteobacteria,2VW0P@28216|Betaproteobacteria,2KXDV@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_574622_1 1380391.JIAS01000012_gene4417 3.89e-108 334.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JR4V@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase central domain - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_468584_1 1397696.KK211189_gene403 1.18e-51 179.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HDD0@91061|Bacilli,3WFYR@539002|Bacillales incertae sedis 91061|Bacilli IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_753268_2 1366050.N234_26740 4.9e-70 214.0 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2VRA3@28216|Betaproteobacteria,1K816@119060|Burkholderiaceae 28216|Betaproteobacteria E glyoxalase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_753268_3 1192124.LIG30_2887 2.86e-19 80.5 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2VSQ1@28216|Betaproteobacteria,1K8EP@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM glutathione-dependent formaldehyde-activating GFA - - - - - - - - - - - - GFA k59_1040011_1 1198452.Jab_2c19580 2.89e-69 219.0 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,2VVFV@28216|Betaproteobacteria,474BI@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4115) - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_649108_1 1000565.METUNv1_02846 5.87e-85 253.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,2KW4Q@206389|Rhodocyclales 206389|Rhodocyclales A 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_649108_2 1000565.METUNv1_02845 9.66e-145 418.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,2KUVU@206389|Rhodocyclales 206389|Rhodocyclales O Zn-dependent protease with chaperone function - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_967359_1 1095769.CAHF01000022_gene262 3.25e-74 231.0 COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,2W99P@28216|Betaproteobacteria,475PD@75682|Oxalobacteraceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1077455_1 1123367.C666_11080 1.96e-07 51.2 28HIY@1|root,2Z7U8@2|Bacteria,1MY3K@1224|Proteobacteria,2VKE4@28216|Betaproteobacteria,2KXYA@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_718427_1 1458275.AZ34_09605 6.38e-72 238.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,4A9VA@80864|Comamonadaceae 28216|Betaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_574632_1 91464.S7335_5106 1.27e-49 181.0 COG0642@1|root,COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1GYFK@1129|Synechococcus 1117|Cyanobacteria T Histidine kinase - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,Response_reg k59_1110190_1 402626.Rpic_3618 2.36e-40 139.0 COG2963@1|root,COG2963@2|Bacteria,1RI5G@1224|Proteobacteria,2VTTM@28216|Betaproteobacteria,1K8KW@119060|Burkholderiaceae 28216|Betaproteobacteria L Helix-turn-helix domain - - - - - - - - - - - - HTH_28 k59_1110190_2 29581.BW37_05456 1.62e-93 278.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2VMCK@28216|Betaproteobacteria,474CU@75682|Oxalobacteraceae 28216|Betaproteobacteria L DDE domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_290653_1 395494.Galf_1432 0.0 1296.0 COG0210@1|root,COG0514@1|root,COG0847@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,COG0847@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,44VG6@713636|Nitrosomonadales 28216|Betaproteobacteria L DEAD DEAH box helicase domain protein - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,UvrD-helicase,UvrD_C k59_327641_1 640081.Dsui_0969 1.17e-97 303.0 COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,2VMR9@28216|Betaproteobacteria,2KW7I@206389|Rhodocyclales 206389|Rhodocyclales S type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_327641_2 243365.CV_3920 1.43e-40 139.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,2KU4I@206351|Neisseriales 206351|Neisseriales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_327641_3 1031711.RSPO_c01215 2.69e-08 54.3 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,1K0BR@119060|Burkholderiaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_753275_1 395495.Lcho_4368 1.85e-25 102.0 COG2865@1|root,COG2865@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - AlbA_2,DUF4062,PHP k59_753275_2 1385935.N836_13440 9.02e-60 204.0 COG0732@1|root,COG0732@2|Bacteria,1G6EU@1117|Cyanobacteria,1HD92@1150|Oscillatoriales 1117|Cyanobacteria L Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_1003676_1 1000565.METUNv1_00345 9e-266 758.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,2KVH6@206389|Rhodocyclales 206389|Rhodocyclales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1003676_2 1000565.METUNv1_00344 8.22e-169 484.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2VI8Z@28216|Betaproteobacteria,2KW53@206389|Rhodocyclales 206389|Rhodocyclales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_1003676_3 1000565.METUNv1_00343 2.09e-54 183.0 COG1538@1|root,COG1538@2|Bacteria,1R744@1224|Proteobacteria,2VJW4@28216|Betaproteobacteria,2KYCU@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_790116_1 1000565.METUNv1_02939 1.01e-166 486.0 COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,2WGGE@28216|Betaproteobacteria 28216|Betaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1040033_1 1397527.Q670_03910 3.05e-37 139.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XIUV@135619|Oceanospirillales 135619|Oceanospirillales NT chemotaxis protein - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1040033_2 1177181.T9A_01061 2.75e-71 224.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RQ5E@1236|Gammaproteobacteria,1XJG4@135619|Oceanospirillales 135619|Oceanospirillales NT COG1352 Methylase of chemotaxis methyl-accepting proteins - - 2.1.1.80 ko:K00575,ko:K02661 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035,ko02044 - - - CheR,CheR_N k59_681827_1 338969.Rfer_1343 7.71e-62 193.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2VSDF@28216|Betaproteobacteria,4AEBW@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein, MerR ycgE - - - - - - - - - - - MerR_1 k59_753280_1 1123393.KB891330_gene791 1.12e-122 359.0 COG1216@1|root,COG1216@2|Bacteria,1RKB9@1224|Proteobacteria,2VNSY@28216|Betaproteobacteria 28216|Betaproteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_434822_1 1245469.S58_39130 6.54e-144 412.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TUVT@28211|Alphaproteobacteria,3JWRX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_649159_1 1157708.KB907452_gene3705 1.25e-160 472.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_184821_1 1000565.METUNv1_03759 2.64e-288 796.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,2KUED@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_254757_1 1000565.METUNv1_00046 1.61e-85 286.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_4196_1 85643.Tmz1t_1047 2.48e-23 99.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,2KUTU@206389|Rhodocyclales 206389|Rhodocyclales L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_4196_2 864073.HFRIS_023711 3.59e-56 182.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,473CE@75682|Oxalobacteraceae 28216|Betaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_506261_1 1000565.METUNv1_02706 7.11e-138 421.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVC1@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_790141_1 85643.Tmz1t_2506 8.51e-59 191.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2VQK6@28216|Betaproteobacteria,2KW9M@206389|Rhodocyclales 206389|Rhodocyclales S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_1077526_1 1000565.METUNv1_01303 3.01e-227 655.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_184853_1 1198452.Jab_1c13410 4.38e-118 360.0 COG1512@1|root,COG1512@2|Bacteria,1QUWH@1224|Proteobacteria,2VN5Z@28216|Betaproteobacteria 28216|Betaproteobacteria S to the C-terminal region of Vibrio parahaemolyticus microbial collagenase precursor PrtVp SWALL COLA_VIBPA (SWALL Q56696) (587 aa) fasta scores E() - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - PPC,Peptidase_M9,Peptidase_M9_N k59_681835_1 1000565.METUNv1_01931 3.68e-173 492.0 COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2VN2J@28216|Betaproteobacteria,2KXQE@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HisKA_2,PAS_9 k59_681835_2 1000565.METUNv1_01932 2.91e-119 341.0 COG1795@1|root,COG1795@2|Bacteria,1MWYS@1224|Proteobacteria,2VNIQ@28216|Betaproteobacteria,2KWDW@206389|Rhodocyclales 206389|Rhodocyclales S Formaldehyde-activating enzyme (Fae) - - - - - - - - - - - - Fae k59_681835_3 1000565.METUNv1_01933 1.89e-69 212.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2VTY8@28216|Betaproteobacteria,2KWX7@206389|Rhodocyclales 206389|Rhodocyclales J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_753300_1 1000565.METUNv1_02027 2.37e-126 362.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2WGQC@28216|Betaproteobacteria,2KZX1@206389|Rhodocyclales 206389|Rhodocyclales C Oxidoreductase FAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_506282_1 317025.Tcr_1657 3.98e-24 99.8 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,460FK@72273|Thiotrichales 72273|Thiotrichales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_506282_2 383407.XOC_0913 3.94e-10 58.5 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1X6WU@135614|Xanthomonadales 135614|Xanthomonadales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_897401_1 1000565.METUNv1_02362 6.92e-104 320.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales 206389|Rhodocyclales T Type IV pili methyl-accepting chemotaxis transducer N-term - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3,PilJ k59_897401_2 338969.Rfer_1869 0.000371 42.4 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,4AAZ1@80864|Comamonadaceae 28216|Betaproteobacteria K response regulator, receiver narL - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_539234_2 1003200.AXXA_27975 3.99e-65 208.0 2DZ82@1|root,32V6V@2|Bacteria,1N3UK@1224|Proteobacteria,2VY68@28216|Betaproteobacteria,3T7VI@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_539234_3 1003200.AXXA_27970 6.68e-10 59.7 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2VSX1@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_4212_1 471870.BACINT_03690 2.34e-26 108.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,2FM9W@200643|Bacteroidia,4ANJ4@815|Bacteroidaceae 976|Bacteroidetes K Psort location Cytoplasmic, score 9.97 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3,Peripla_BP_4 k59_4212_2 649349.Lbys_3011 4.07e-19 89.4 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,47Y6D@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_184878_1 29581.BW37_04343 9.99e-44 163.0 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2WBW0@28216|Betaproteobacteria,476JM@75682|Oxalobacteraceae 28216|Betaproteobacteria H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_967411_1 1218352.B597_018385 4.16e-85 256.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1Z2MZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_967411_2 365044.Pnap_2041 1.82e-44 154.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,4AAQE@80864|Comamonadaceae 28216|Betaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_290733_1 614083.AWQR01000009_gene634 1.52e-120 372.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,4A9PS@80864|Comamonadaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_860350_2 1122603.ATVI01000006_gene186 6.2e-44 156.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1X4KT@135614|Xanthomonadales 135614|Xanthomonadales O Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_111119_1 614083.AWQR01000011_gene2319 1.63e-98 304.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,4A9US@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_327752_1 1210884.HG799463_gene9801 2.01e-55 196.0 COG2755@1|root,COG3345@1|root,COG5306@1|root,COG2755@2|Bacteria,COG3345@2|Bacteria,COG5306@2|Bacteria,2IYTG@203682|Planctomycetes 203682|Planctomycetes E Domain of unknown function (DUF2341) - - - - - - - - - - - - DUF2341,Laminin_G_3,SASA k59_967416_1 497321.C664_16013 2.43e-67 214.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_217509_1 1122603.ATVI01000006_gene654 4.96e-143 411.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X88E@135614|Xanthomonadales 135614|Xanthomonadales E alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_609802_1 396595.TK90_1119 2.26e-23 100.0 COG2199@1|root,COG2199@2|Bacteria,1R4XN@1224|Proteobacteria,1RQ6S@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - GGDEF,PAS_4 k59_897429_1 1000565.METUNv1_01666 1.33e-48 169.0 COG2982@1|root,COG2982@2|Bacteria,1RD61@1224|Proteobacteria,2VS09@28216|Betaproteobacteria,2KWG8@206389|Rhodocyclales 206389|Rhodocyclales M AsmA-like C-terminal region - - - - - - - - - - - - AsmA_2 k59_1077596_1 1000565.METUNv1_02874 3.72e-94 285.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,2KV4N@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_897436_1 864073.HFRIS_008246 5.52e-84 273.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4736T@75682|Oxalobacteraceae 28216|Betaproteobacteria P Cation transporter/ATPase, N-terminus mgtA - 3.6.3.2 ko:K01531 - - - - ko00000,ko01000 3.A.3.4 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_184927_1 1380387.JADM01000006_gene1214 5.41e-36 133.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1XH2N@135619|Oceanospirillales 135619|Oceanospirillales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_897441_1 1000565.METUNv1_01006 2.06e-119 362.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VI9T@28216|Betaproteobacteria,2KVW2@206389|Rhodocyclales 206389|Rhodocyclales EQ Hydantoinase B/oxoprolinase acxB - 6.4.1.6 ko:K10854 - - - - ko00000,ko01000 - - - Hydantoinase_B k59_468699_1 1000565.METUNv1_02412 5.42e-102 312.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUQA@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_198994_1 1000565.METUNv1_00115 2e-86 283.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales 206389|Rhodocyclales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_726576_1 1237149.C900_04433 5.77e-22 103.0 COG3188@1|root,COG3188@2|Bacteria,4NHVA@976|Bacteroidetes,47MA8@768503|Cytophagia 976|Bacteroidetes NU Pkd domain containing protein - - - - - - - - - - - - - k59_371679_1 1211114.ALIP01000032_gene1560 5.12e-133 384.0 COG2253@1|root,COG2253@2|Bacteria,1NJT9@1224|Proteobacteria,1S0YI@1236|Gammaproteobacteria,1X3NZ@135614|Xanthomonadales 135614|Xanthomonadales S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_405301_1 485916.Dtox_3410 2.44e-24 103.0 COG3385@1|root,COG3385@2|Bacteria,1VUF8@1239|Firmicutes,250BF@186801|Clostridia 186801|Clostridia L Transposase DNA-binding - - - - - - - - - - - - DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_155758_2 557598.LHK_01182 1.46e-36 132.0 COG0715@1|root,COG0715@2|Bacteria,1PDWW@1224|Proteobacteria,2VIDB@28216|Betaproteobacteria,2KPK4@206351|Neisseriales 206351|Neisseriales P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_974904_1 232721.Ajs_0585 5e-51 177.0 COG1538@1|root,COG1538@2|Bacteria,1Q498@1224|Proteobacteria,2VJCB@28216|Betaproteobacteria,4ABRA@80864|Comamonadaceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - ko:K12538 - M00328 - - ko00000,ko00002,ko02000,ko02044 1.B.17.1 - - OEP k59_263806_1 1223521.BBJX01000001_gene895 2.21e-69 215.0 COG2050@1|root,COG2050@2|Bacteria,1RHNM@1224|Proteobacteria,2VT6C@28216|Betaproteobacteria,4AHM3@80864|Comamonadaceae 28216|Betaproteobacteria Q Domain of unknown function (DUF4442) - - - - - - - - - - - - DUF4442 k59_155759_1 926562.Oweho_1037 3.75e-36 128.0 2CG1Y@1|root,31NHZ@2|Bacteria,4NQ9Z@976|Bacteroidetes,1I375@117743|Flavobacteriia,2PAZS@246874|Cryomorphaceae 976|Bacteroidetes S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 k59_520382_1 511.JT27_00560 0.000525 43.5 2EB84@1|root,3358M@2|Bacteria,1N7EA@1224|Proteobacteria,2VWD8@28216|Betaproteobacteria,3T5YE@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_520382_3 1207076.ALAT01000105_gene1945 1.38e-110 328.0 COG0270@1|root,COG0270@2|Bacteria,1NPQG@1224|Proteobacteria,1S07Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_1117569_1 477184.KYC_15962 0.000172 43.1 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,3T2X3@506|Alcaligenaceae 28216|Betaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_1117569_2 1000565.METUNv1_02731 5.85e-26 98.2 COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,2KXMD@206389|Rhodocyclales 206389|Rhodocyclales S Pfam:DUF1049 - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_547324_1 382464.ABSI01000013_gene1857 2.46e-21 98.2 COG4888@1|root,COG4888@2|Bacteria,46UDG@74201|Verrucomicrobia 74201|Verrucomicrobia O PFAM ASPIC UnbV domain protein - - - - - - - - - - - - FG-GAP,UnbV_ASPIC,VCBS k59_581583_1 1000565.METUNv1_02939 7.93e-86 272.0 COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,2WGGE@28216|Betaproteobacteria 28216|Betaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_155771_1 1218084.BBJK01000003_gene378 3.15e-168 474.0 COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,1K13V@119060|Burkholderiaceae 28216|Betaproteobacteria S Amidohydrolase ligJ - 4.1.1.46,4.2.1.83 ko:K10220,ko:K14333 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R00821,R04478 RC00390,RC00498 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1089501_1 1221522.B723_11025 2.7e-21 87.4 2E184@1|root,32WNP@2|Bacteria,1N4AP@1224|Proteobacteria,1SANZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_451696_1 1198452.Jab_2c19910 1.52e-153 440.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,472V7@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_451699_2 391598.FBBAL38_00500 4.38e-27 110.0 COG0659@1|root,COG0659@2|Bacteria,4NE9G@976|Bacteroidetes,1HYXB@117743|Flavobacteriia 976|Bacteroidetes P COG0659 Sulfate permease and related sulP - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Sulfate_transp k59_478902_1 1117647.M5M_04905 4.06e-41 143.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1J5VT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG0739 Membrane proteins related to metalloendopeptidases nlpD GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944 - ko:K06194,ko:K12943 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_478902_2 640081.Dsui_1971 1.91e-80 249.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,2VIUT@28216|Betaproteobacteria,2KUKV@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_225122_1 1538295.JY96_03775 3.4e-08 52.8 2A94H@1|root,30Y8N@2|Bacteria,1PK47@1224|Proteobacteria,2W8EQ@28216|Betaproteobacteria,1KMTS@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - ko:K06950 - - - - ko00000 - - - - k59_225122_2 1000565.METUNv1_00211 9.74e-23 98.6 COG5000@1|root,COG5000@2|Bacteria,1QVAT@1224|Proteobacteria,2WGR4@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_50502_1 402626.Rpic_2494 1.54e-39 145.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,1JZS1@119060|Burkholderiaceae 28216|Betaproteobacteria G PQQ-dependent dehydrogenase, methanol ethanol family - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_50502_2 1198452.Jab_1c10390 5.46e-25 95.5 COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,2VSRW@28216|Betaproteobacteria,474QJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF779) - - - ko:K09959 - - - - ko00000 - - - DUF779 k59_302092_1 1219031.BBJR01000021_gene2496 1.18e-48 176.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,4AB1Y@80864|Comamonadaceae 28216|Betaproteobacteria KL SMART helicase c2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_85504_2 1118235.CAJH01000013_gene819 1.92e-62 204.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_50511_2 862908.BMS_3002 1e-43 152.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,43AFB@68525|delta/epsilon subdivisions 1224|Proteobacteria P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K02033,ko:K15585 ko02010,ko02024,map02010,map02024 M00239,M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_761612_1 1122951.ATUE01000006_gene1144 2.93e-89 285.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,1T9YW@1236|Gammaproteobacteria,3NNXI@468|Moraxellaceae 1236|Gammaproteobacteria C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_265293_1 1000565.METUNv1_02519 3.68e-50 167.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2VQ5Z@28216|Betaproteobacteria,2KUJK@206389|Rhodocyclales 206389|Rhodocyclales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH padA - - ko:K18360 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001 - - - FdhD-NarQ k59_265293_2 1000565.METUNv1_02518 5.59e-33 115.0 2E4CR@1|root,32Z86@2|Bacteria,1N7UZ@1224|Proteobacteria,2VVR1@28216|Betaproteobacteria,2KZJP@206389|Rhodocyclales 206389|Rhodocyclales S NADH-dependant formate dehydrogenase delta subunit FdsD - - 1.17.1.9 ko:K00126 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - FdsD k59_265293_3 3988.XP_002538048.1 1.4e-10 60.8 COG1335@1|root,2RXWW@2759|Eukaryota 2759|Eukaryota Q Isochorismatase - - - - - - - - - - - - Isochorismatase k59_1014127_2 700598.Niako_5604 2.35e-59 201.0 COG0317@1|root,COG0317@2|Bacteria,4NESY@976|Bacteroidetes,1IQ2F@117747|Sphingobacteriia 976|Bacteroidetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_522756_1 1000565.METUNv1_02701 3.21e-47 163.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KVSS@206389|Rhodocyclales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23,OmpA k59_373196_1 381666.H16_A0009 7.41e-168 480.0 COG4268@1|root,COG4268@2|Bacteria,1PK1W@1224|Proteobacteria,2W8CQ@28216|Betaproteobacteria,1KEU6@119060|Burkholderiaceae 28216|Betaproteobacteria V McrBC 5-methylcytosine restriction system component - - - ko:K19147 - - - - ko00000,ko02048 - - - McrBC k59_265312_1 1191299.AJYX01000071_gene1192 1.46e-26 108.0 arCOG09511@1|root,2Z9DH@2|Bacteria,1MXRV@1224|Proteobacteria,1SEJ5@1236|Gammaproteobacteria,1XZ1Y@135623|Vibrionales 135623|Vibrionales S FRG - - - - - - - - - - - - FRG k59_907045_1 929703.KE386491_gene2463 2.05e-103 308.0 COG0191@1|root,COG0191@2|Bacteria,4NF5C@976|Bacteroidetes,47MC3@768503|Cytophagia 976|Bacteroidetes G fructose-bisphosphate aldolase, class II, yeast E. coli subtype fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_761630_1 349161.Dred_1977 2.89e-64 203.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,260PI@186807|Peptococcaceae 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_835911_1 756067.MicvaDRAFT_1204 4.05e-13 78.6 COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1G2A7@1117|Cyanobacteria,1H9SV@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_835911_2 1123393.KB891330_gene805 1.05e-55 188.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,1KSY0@119069|Hydrogenophilales 119069|Hydrogenophilales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_616936_1 1121033.AUCF01000031_gene96 2.06e-72 234.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales 204441|Rhodospirillales I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_548905_1 998088.B565_0866 3.46e-56 184.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1Y3H9@135624|Aeromonadales 135624|Aeromonadales J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_451802_1 1196835.A458_15145 5.23e-05 44.7 COG1028@1|root,COG1028@2|Bacteria,1RAEZ@1224|Proteobacteria,1S26F@1236|Gammaproteobacteria,1Z2P8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria IQ Dehydrogenase - - - - - - - - - - - - adh_short,adh_short_C2 k59_451802_2 1100721.ALKO01000021_gene593 9.16e-23 89.7 2C5D1@1|root,32YFH@2|Bacteria,1N97Z@1224|Proteobacteria,2VWCU@28216|Betaproteobacteria,4AIH1@80864|Comamonadaceae 28216|Betaproteobacteria S Tryptophan-rich protein (DUF2389) - - - - - - - - - - - - DUF2389 k59_451802_3 358220.C380_16325 3.51e-15 75.1 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,4AB3G@80864|Comamonadaceae 28216|Betaproteobacteria S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_50552_1 1177181.T9A_00198 1.46e-52 180.0 COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,1RRN8@1236|Gammaproteobacteria,1XJ31@135619|Oceanospirillales 135619|Oceanospirillales C COG0277 FAD FMN-containing dehydrogenases - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_548922_1 1286631.X805_20650 9.26e-80 240.0 2DBG4@1|root,2Z927@2|Bacteria,1N7I6@1224|Proteobacteria,2VQ2P@28216|Betaproteobacteria,1KJ7E@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways flhC - - ko:K02402 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlhC k59_548922_2 614083.AWQR01000046_gene3338 6.49e-18 78.2 2AX91@1|root,31P80@2|Bacteria,1N25K@1224|Proteobacteria,2VSYQ@28216|Betaproteobacteria,4AEIJ@80864|Comamonadaceae 28216|Betaproteobacteria N Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways flhD - - ko:K02403 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlhD k59_940034_1 1000565.METUNv1_03820 8.3e-61 209.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales 206389|Rhodocyclales P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_85564_1 1547437.LL06_17130 3.57e-21 91.7 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43J3W@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q COG1233 Phytoene dehydrogenase and related - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_85564_2 1089453.GOSPT_118_01000 1.6e-09 63.5 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4GCB7@85026|Gordoniaceae 201174|Actinobacteria Q FAD dependent oxidoreductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Amino_oxidase,DAO,NAD_binding_8 k59_522829_1 614083.AWQR01000029_gene2075 9.02e-98 302.0 COG1807@1|root,COG1807@2|Bacteria,1R7N1@1224|Proteobacteria,2VPJR@28216|Betaproteobacteria,4AHH4@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM glycosyl transferase family 39 - - - - - - - - - - - - PMT k59_976368_1 614083.AWQR01000018_gene1764 2.18e-118 349.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,4AAJ4@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM aminotransferase, class I and II dapC - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_801122_1 1122951.ATUE01000005_gene2238 1.14e-108 344.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,1T1Q4@1236|Gammaproteobacteria,3NJAQ@468|Moraxellaceae 1236|Gammaproteobacteria T PAS domain pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS,PAS_8 k59_344040_1 1095769.CAHF01000014_gene2960 7.17e-102 299.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,4745N@75682|Oxalobacteraceae 28216|Betaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_201342_1 1298593.TOL_1437 5.88e-14 71.6 2EJUZ@1|root,33DJM@2|Bacteria,1NIYD@1224|Proteobacteria,1SGV4@1236|Gammaproteobacteria,1XMNZ@135619|Oceanospirillales 135619|Oceanospirillales S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_1119078_1 614083.AWQR01000013_gene1710 2.06e-75 228.0 COG2816@1|root,COG2816@2|Bacteria,1REUJ@1224|Proteobacteria,2VRF4@28216|Betaproteobacteria,4ADHV@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM NUDIX hydrolase - - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,Nudix_N_2 k59_1050694_1 340177.Cag_1910 4.19e-13 74.7 COG0823@1|root,COG0823@2|Bacteria,1FEIQ@1090|Chlorobi 1090|Chlorobi U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_50585_1 1198452.Jab_1c15250 2.83e-85 269.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,472NJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_522864_1 640081.Dsui_1952 1.21e-95 288.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,2KV89@206389|Rhodocyclales 206389|Rhodocyclales M pfkB family carbohydrate kinase - - 2.7.1.167 ko:K21344 ko00540,map00540 M00064 R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_212162_1 1123255.JHYS01000020_gene2733 7.76e-90 271.0 COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,2VR50@28216|Betaproteobacteria,4ADVD@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant - - 3.1.3.102,3.1.3.104 ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD_2,Hydrolase k59_212162_2 391735.Veis_1574 9.51e-14 70.1 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,4ABIW@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_356880_1 1112209.AHVZ01000026_gene1427 1.51e-90 270.0 COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria,1MU8Y@1224|Proteobacteria,1RN7J@1236|Gammaproteobacteria,3NJ8Q@468|Moraxellaceae 1236|Gammaproteobacteria C Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins nfuA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010467,GO:0015976,GO:0016043,GO:0016226,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 - ko:K07400 - - - - ko00000 - - - Fe-S_biosyn,NifU k59_382419_1 1005048.CFU_1160 0.000702 48.5 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VPBJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid k59_844389_1 1121920.AUAU01000002_gene2012 5.1e-57 184.0 COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria 57723|Acidobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG k59_734930_1 614083.AWQR01000006_gene346 9.68e-51 162.0 COG0662@1|root,COG0662@2|Bacteria,1QVI4@1224|Proteobacteria,2WGS5@28216|Betaproteobacteria,4AJXG@80864|Comamonadaceae 28216|Betaproteobacteria G Mannose-6-phosphate isomerase - - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer k59_1022285_1 1313421.JHBV01000072_gene4639 2.35e-25 106.0 COG1361@1|root,COG3210@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125,ko:K20276 ko02024,ko05133,map02024,map05133 - - - ko00000,ko00001,ko00536 - - - CHU_C,DUF11,PMT_2,WD40 k59_356893_1 1348657.M622_18480 3.07e-104 323.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VHBK@28216|Betaproteobacteria,2KVTF@206389|Rhodocyclales 206389|Rhodocyclales V COG0286 Type I restriction-modification system methyltransferase subunit - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_622738_1 497321.C664_02370 3.57e-72 226.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,2VIBG@28216|Betaproteobacteria,2KUW1@206389|Rhodocyclales 206389|Rhodocyclales C COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases - - - ko:K16246 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_622738_2 640081.Dsui_1116 6.95e-57 200.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VIB2@28216|Betaproteobacteria,2KUPS@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_557930_1 1122951.ATUE01000009_gene427 8.9e-103 308.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,3NJ8P@468|Moraxellaceae 1236|Gammaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_734940_1 358220.C380_23720 1.86e-127 377.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VP9W@28216|Betaproteobacteria,4ACZP@80864|Comamonadaceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_734940_2 358220.C380_23715 3.59e-78 244.0 COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,4AAZP@80864|Comamonadaceae 1224|Proteobacteria E amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1062650_1 311403.Arad_9323 3.26e-10 65.1 COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2TSWT@28211|Alphaproteobacteria,4BMUS@82115|Rhizobiaceae 28211|Alphaproteobacteria EG of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_1125967_2 587753.EY04_15130 1.27e-52 171.0 2CK9C@1|root,30CP8@2|Bacteria,1N20B@1224|Proteobacteria,1SAE5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1125967_3 395495.Lcho_2270 0.000353 42.0 COG1414@1|root,COG1414@2|Bacteria,1QXAS@1224|Proteobacteria,2VY66@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_IclR k59_164947_1 358220.C380_11955 3.16e-79 239.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2VQKU@28216|Betaproteobacteria,4ADGZ@80864|Comamonadaceae 28216|Betaproteobacteria P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides chaC - - ko:K07232 - - - - ko00000 - - - ChaC k59_1095358_1 614083.AWQR01000010_gene1546 2.27e-100 294.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,4ADPE@80864|Comamonadaceae 28216|Betaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_622777_1 1144319.PMI16_01465 1.49e-21 92.8 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria 1224|Proteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - ko:K02030,ko:K10001 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_622777_2 1122603.ATVI01000006_gene55 1.06e-58 199.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,1T1KJ@1236|Gammaproteobacteria,1X478@135614|Xanthomonadales 135614|Xanthomonadales E Prolyl oligopeptidase - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_93588_1 1396858.Q666_15920 7.75e-45 164.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,465M4@72275|Alteromonadaceae 1236|Gammaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_734981_1 1121923.GPUN_1931 4.15e-62 202.0 COG1161@1|root,COG1161@2|Bacteria,1MV5H@1224|Proteobacteria,1RP79@1236|Gammaproteobacteria,465CA@72275|Alteromonadaceae 1236|Gammaproteobacteria S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity rbgA - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_231786_1 640081.Dsui_3464 4.63e-88 265.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VMYS@28216|Betaproteobacteria,2KZRS@206389|Rhodocyclales 206389|Rhodocyclales P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_463915_1 1000565.METUNv1_03850 6.24e-130 374.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,2KV9H@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_463915_2 1000565.METUNv1_03851 1.1e-240 667.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,2KUEI@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_93611_1 1095769.CAHF01000011_gene2703 5.86e-38 144.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,472EF@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1022391_1 614083.AWQR01000018_gene1762 1.02e-79 248.0 COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,4ABGH@80864|Comamonadaceae 28216|Betaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA - - - - - - - - - - - ZipA_C k59_913941_1 999419.HMPREF1077_02758 6.63e-08 54.3 COG0497@1|root,COG0497@2|Bacteria,4NE3I@976|Bacteroidetes,2FMIG@200643|Bacteroidia,22W29@171551|Porphyromonadaceae 976|Bacteroidetes L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_212334_1 1538295.JY96_08700 4.01e-103 313.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1KJ8G@119065|unclassified Burkholderiales 28216|Betaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_165002_1 927658.AJUM01000022_gene1211 3.03e-61 209.0 COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,2FNJA@200643|Bacteroidia,3XJ84@558415|Marinilabiliaceae 976|Bacteroidetes P E1-E2 ATPase actP - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_698630_1 1385935.N836_04460 1e-26 109.0 COG1216@1|root,COG1216@2|Bacteria,1GBJC@1117|Cyanobacteria 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_413432_1 485918.Cpin_1000 8.38e-53 177.0 COG2059@1|root,COG2059@2|Bacteria,4NNZ1@976|Bacteroidetes,1INNP@117747|Sphingobacteriia 976|Bacteroidetes P TIGRFAM chromate transporter, chromate ion transporter (CHR) family - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_1062806_2 1121035.AUCH01000006_gene763 2.23e-13 70.1 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,2KVMW@206389|Rhodocyclales 206389|Rhodocyclales K RNB - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_212349_1 471854.Dfer_2876 9.83e-101 306.0 COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,47MAV@768503|Cytophagia 976|Bacteroidetes E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_879121_1 1276756.AUEX01000008_gene3220 3.39e-105 320.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,4AACA@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_382640_1 391735.Veis_3576 3.13e-59 193.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4ABW2@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_382640_2 1408164.MOLA814_02426 1.17e-25 101.0 COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,2VIMR@28216|Betaproteobacteria 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K17317 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 k59_165028_1 614083.AWQR01000038_gene1417 3.57e-64 203.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,4ABX3@80864|Comamonadaceae 28216|Betaproteobacteria OU peptidase S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_165028_2 614083.AWQR01000038_gene1416 2.07e-25 100.0 COG0313@1|root,COG0313@2|Bacteria,1RARW@1224|Proteobacteria,2VQ34@28216|Betaproteobacteria,4AAHJ@80864|Comamonadaceae 28216|Betaproteobacteria H Uroporphyrin-iii c tetrapyrrole (Corrin porphyrin) methyltransferase rsmI_2 - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_22022_1 349521.HCH_01753 3.78e-56 195.0 COG0427@1|root,COG0427@2|Bacteria,1PJY0@1224|Proteobacteria,1RPS6@1236|Gammaproteobacteria,1XKCF@135619|Oceanospirillales 135619|Oceanospirillales C Acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_382678_1 1122951.ATUE01000008_gene189 2e-92 286.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,3NIEX@468|Moraxellaceae 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_212394_1 1123253.AUBD01000007_gene712 3.39e-68 217.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1X38D@135614|Xanthomonadales 135614|Xanthomonadales M synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_698669_1 1454004.AW11_02409 4.79e-36 131.0 COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,2VJDC@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the NiCoT transporter (TC 2.A.52) family hoxN - - ko:K07241 - - - - ko00000,ko02000 2.A.52.1 - - NicO k59_128928_1 487316.BBNM01000004_gene518 4.1e-20 89.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,3NK5Q@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the thiolase family fadI - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_128928_2 110319.CF8_2309 2.48e-05 45.4 COG1028@1|root,COG1028@2|Bacteria,2GJCZ@201174|Actinobacteria,4DN55@85009|Propionibacteriales 201174|Actinobacteria IQ KR domain fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_231853_1 1000565.METUNv1_03348 4.49e-68 214.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KU8W@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_231853_2 1000565.METUNv1_03347 4.62e-34 127.0 COG0079@1|root,COG0079@2|Bacteria,1MXDP@1224|Proteobacteria,2VKTS@28216|Betaproteobacteria,2KU6R@206389|Rhodocyclales 206389|Rhodocyclales E COG0079 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase cobC - - ko:K02225 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002 - - - Aminotran_1_2 k59_312008_1 1221522.B723_11010 1.39e-15 72.8 COG3311@1|root,COG3311@2|Bacteria,1NGB9@1224|Proteobacteria,1SGDV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K07733 - - - - ko00000,ko03000 - - - Phage_AlpA k59_413471_1 1273125.Rrhod_0565 1.06e-36 130.0 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4G0E8@85025|Nocardiaceae 201174|Actinobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_413473_1 1157708.KB907451_gene4908 1.09e-50 171.0 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria,4AASB@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM NAD-dependent epimerase dehydratase - - 1.1.1.410 ko:K22025 - - - - ko00000,ko01000 - - - Epimerase k59_413473_2 1042209.HK44_006345 2.81e-05 45.1 COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,1RQXA@1236|Gammaproteobacteria,1YPSR@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I Acetohydroxy acid isomeroreductase, NADPH-binding domain ygbJ - 1.1.1.411 ko:K08319 - - - - ko00000,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_589408_1 1209072.ALBT01000032_gene2039 1.79e-118 352.0 COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,1RMZZ@1236|Gammaproteobacteria,1FI5K@10|Cellvibrio 1236|Gammaproteobacteria P Major Facilitator Superfamily fsr GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944 - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1 k59_1064876_1 1000565.METUNv1_03281 4.19e-94 279.0 COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2VH4B@28216|Betaproteobacteria,2KU7J@206389|Rhodocyclales 206389|Rhodocyclales S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_985369_1 999141.GME_09941 3.53e-61 195.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1XJCE@135619|Oceanospirillales 135619|Oceanospirillales D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_985369_2 1121013.P873_08410 2.15e-06 48.9 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1X4KE@135614|Xanthomonadales 135614|Xanthomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1023908_1 927658.AJUM01000044_gene643 1.06e-26 113.0 COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes,2FP7Y@200643|Bacteroidia,3XKPS@558415|Marinilabiliaceae 976|Bacteroidetes O Peptidase family M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_313674_1 1322246.BN4_12505 2.24e-12 72.0 COG2199@1|root,COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,43EHM@68525|delta/epsilon subdivisions,2X8EA@28221|Deltaproteobacteria,2MHH2@213115|Desulfovibrionales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_9 k59_880509_1 983917.RGE_10780 1.53e-18 93.2 COG3664@1|root,COG3664@2|Bacteria,1MX9Q@1224|Proteobacteria,2W20Q@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM glycoside hydrolase family 39 - - - - - - - - - - - - - k59_880509_2 1382359.JIAL01000001_gene2171 1.82e-05 45.8 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG3 - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_95142_2 1123229.AUBC01000004_gene3019 2.95e-67 216.0 COG0107@1|root,COG0107@2|Bacteria 1123229.AUBC01000004_gene3019|- E imidazoleglycerol-phosphate synthase activity - - - - - - - - - - - - - k59_1096298_1 1198452.Jab_1c06220 2.77e-147 427.0 COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,475KH@75682|Oxalobacteraceae 28216|Betaproteobacteria T Domain of unknown function (DUF3369) - - - - - - - - - - - - DUF3369,HD,HD_5,Response_reg k59_130370_1 795666.MW7_1076 6.92e-67 221.0 COG3378@1|root,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,2VM9Y@28216|Betaproteobacteria,1K6UZ@119060|Burkholderiaceae 28216|Betaproteobacteria S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N,PriCT_2 k59_130370_2 380358.XALC_2391 1.46e-10 58.9 COG0817@1|root,COG0817@2|Bacteria,1RCYK@1224|Proteobacteria,1S3HF@1236|Gammaproteobacteria,1X622@135614|Xanthomonadales 135614|Xanthomonadales L genomic island protein Bartonella henselae str. Houston-1 gi 49238285 emb CAF27499.1 and to - - - - - - - - - - - - - k59_559757_1 1198452.Jab_1c06360 2.55e-112 357.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,4726T@75682|Oxalobacteraceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_985424_1 883126.HMPREF9710_04469 5.35e-56 189.0 COG2755@1|root,COG2755@2|Bacteria,1RDF0@1224|Proteobacteria 1224|Proteobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_23291_1 1177154.Y5S_03311 7.27e-71 231.0 KOG2232@1|root,2Z84X@2|Bacteria,1PYBJ@1224|Proteobacteria,1TBJV@1236|Gammaproteobacteria,1XPD7@135619|Oceanospirillales 135619|Oceanospirillales S Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - - - - - - - - - - Ceramidase_alk k59_489741_1 742159.HMPREF0004_5621 8.84e-87 267.0 COG1146@1|root,COG1146@2|Bacteria,1MU2I@1224|Proteobacteria,2VJHI@28216|Betaproteobacteria,3T21S@506|Alcaligenaceae 28216|Betaproteobacteria C utilization protein B citB - - ko:K13795 - - - - ko00000 - - - - k59_590618_1 472759.Nhal_3250 7.78e-25 100.0 COG0110@1|root,COG0110@2|Bacteria,1N0CM@1224|Proteobacteria 1224|Proteobacteria S maltose O-acetyltransferase activity - - - - - - - - - - - - Hexapep k59_1064978_1 1198452.Jab_1c07480 7.92e-70 214.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,472PF@75682|Oxalobacteraceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_880552_1 1538295.JY96_10415 1.7e-08 60.1 COG3637@1|root,COG3637@2|Bacteria,1N1WQ@1224|Proteobacteria,2VMY3@28216|Betaproteobacteria,1KJWH@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Putative beta-barrel porin-2, OmpL-like. bbp2 - - - - - - - - - - - - DUF3138 k59_736325_2 395494.Galf_1839 6.06e-31 119.0 COG3550@1|root,COG3550@2|Bacteria,1QJ5P@1224|Proteobacteria,2VNBA@28216|Betaproteobacteria,44WFK@713636|Nitrosomonadales 28216|Betaproteobacteria S Pfam:HipA_N - - - - - - - - - - - - HTH_24,HipA_C k59_985469_1 640081.Dsui_2686 4.58e-79 256.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_985469_2 522306.CAP2UW1_2869 5.67e-09 56.2 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1KQ8B@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Peptidase family M50 rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_857723_2 1121921.KB898708_gene1533 1.88e-47 169.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,2PN2Z@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L SMC proteins Flexible Hinge Domain smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_572157_1 202955.BBND01000008_gene2207 9.29e-79 244.0 COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,1T1QK@1236|Gammaproteobacteria,3NJ16@468|Moraxellaceae 1236|Gammaproteobacteria P Catalase - - - - - - - - - - - - Catalase k59_572157_2 1122179.KB890423_gene2314 3.59e-18 84.3 COG0793@1|root,COG0793@2|Bacteria,4NEFX@976|Bacteroidetes,1IY6Q@117747|Sphingobacteriia 976|Bacteroidetes M Peptidase family S41 - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S41,Tricorn_C1 k59_180400_1 76114.ebA4709 3.77e-45 163.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KUV9@206389|Rhodocyclales 206389|Rhodocyclales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_536565_1 1000565.METUNv1_02621 5.23e-115 336.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,2VN5G@28216|Betaproteobacteria,2KUP2@206389|Rhodocyclales 206389|Rhodocyclales NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_536565_2 1000565.METUNv1_02620 4.77e-80 238.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria,2KWC5@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_536565_3 1121035.AUCH01000020_gene2689 1.34e-13 69.3 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria,2KV3U@206389|Rhodocyclales 206389|Rhodocyclales T Chemotaxis signal transduction protein - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_679331_1 1537715.JQFJ01000002_gene1346 1.85e-15 89.4 COG2911@1|root,COG3210@1|root,COG3468@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,2TX9B@28211|Alphaproteobacteria,2KENE@204457|Sphingomonadales 204457|Sphingomonadales MU Autotransporter beta-domain - - - ko:K19231 - - - - ko00000,ko02000 1.B.12 - - PATR k59_1072852_1 1000565.METUNv1_03388 4.18e-112 333.0 COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,2VHD9@28216|Betaproteobacteria,2KUNH@206389|Rhodocyclales 206389|Rhodocyclales U glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_144101_1 1123255.JHYS01000003_gene3015 1.21e-10 61.6 COG1570@1|root,COG1570@2|Bacteria,1N04I@1224|Proteobacteria,2VUCX@28216|Betaproteobacteria,4AECW@80864|Comamonadaceae 28216|Betaproteobacteria L Plasmid replication region DNA-binding N-term - - - - - - - - - - - - KfrA_N k59_1000757_1 365046.Rta_09100 7.6e-102 300.0 COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,2VKE3@28216|Betaproteobacteria,4ABAH@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N k59_1036608_1 1000565.METUNv1_00279 4.18e-103 300.0 COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2VSMR@28216|Betaproteobacteria,2KW1T@206389|Rhodocyclales 206389|Rhodocyclales T ANTAR - - - ko:K07183 - - - - ko00000,ko02022 - - - ANTAR,Response_reg k59_857731_1 29581.BW37_04707 5.78e-101 304.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,4734Z@75682|Oxalobacteraceae 28216|Betaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_964893_2 1000565.METUNv1_03290 1.02e-158 451.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VIUW@28216|Betaproteobacteria,2KUNG@206389|Rhodocyclales 206389|Rhodocyclales E HMGL-like hmgL - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_964893_3 1000565.METUNv1_03291 9.02e-133 382.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,2KU7S@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1472_1 1000565.METUNv1_00415 4.74e-108 342.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg k59_72547_1 582744.Msip34_1632 7.37e-137 401.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,2VJZR@28216|Betaproteobacteria 28216|Betaproteobacteria S to Bacillus subtilis pbsx phage terminase large subunit xtmB SWALL XTMB_BACSU (SWALL P39786) (433 aa) fasta scores E() 0.2, 21.58 id in 417 aa, and to Yersinia pestis - - - - - - - - - - - - Terminase_6,Terminase_6C k59_572167_1 1000565.METUNv1_02736 3.87e-144 426.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria,2KV82@206389|Rhodocyclales 206389|Rhodocyclales S Protein conserved in bacteria - - - - - - - - - - - - - k59_1107754_1 1000565.METUNv1_02603 8.7e-163 459.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VHPX@28216|Betaproteobacteria,2KU78@206389|Rhodocyclales 206389|Rhodocyclales N flagellar motor - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_394231_1 398578.Daci_4538 1.87e-69 227.0 COG1073@1|root,COG1073@2|Bacteria,1QTY2@1224|Proteobacteria,2VK86@28216|Betaproteobacteria,4AB75@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Tannase and feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_679344_1 497964.CfE428DRAFT_4248 0.00074 49.3 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia 2|Bacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8 k59_180421_1 1000565.METUNv1_00048 5.03e-155 447.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2WF8A@28216|Betaproteobacteria 28216|Betaproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_180421_2 1000565.METUNv1_00050 2.74e-56 183.0 COG1639@1|root,COG1639@2|Bacteria,1RASR@1224|Proteobacteria,2VR0D@28216|Betaproteobacteria,2KWNY@206389|Rhodocyclales 206389|Rhodocyclales T HDOD domain - - - - - - - - - - - - HDOD k59_1000761_1 1000565.METUNv1_02461 4.47e-177 509.0 COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,2KUDR@206389|Rhodocyclales 206389|Rhodocyclales S CHAD domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHAD,CYTH k59_1000761_2 1000565.METUNv1_02462 1.06e-90 268.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,2KW2Z@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_1000761_3 1000565.METUNv1_02463 7.05e-60 187.0 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2WGQ0@28216|Betaproteobacteria,2KWBX@206389|Rhodocyclales 28216|Betaproteobacteria T response regulator - - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg k59_465456_2 440512.C211_04145 6.51e-90 274.0 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,1SQ0T@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_465456_9 1286093.C266_02526 2e-50 171.0 COG4678@1|root,COG4678@2|Bacteria,1N2BW@1224|Proteobacteria,2VVEP@28216|Betaproteobacteria,1KA0V@119060|Burkholderiaceae 28216|Betaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_465456_11 1112217.PPL19_22942 7.43e-35 135.0 COG4675@1|root,COG4675@2|Bacteria,1RDJW@1224|Proteobacteria,1S415@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tail collar domain protein - - - - - - - - - - - - Collar,Phage_fiber_2 k59_465456_17 1286093.C266_02556 6.92e-53 180.0 28JV9@1|root,2Z9K8@2|Bacteria,1MVTX@1224|Proteobacteria,2VP25@28216|Betaproteobacteria,1K37M@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_465456_19 265072.Mfla_0972 4.29e-57 185.0 COG0433@1|root,COG0433@2|Bacteria,1N2WU@1224|Proteobacteria,2VUFK@28216|Betaproteobacteria 28216|Betaproteobacteria S COG0433 Predicted ATPase - - - - - - - - - - - - DUF87 k59_465456_24 1123487.KB892865_gene1360 9.87e-154 470.0 28HIF@1|root,2Z7TX@2|Bacteria,1MY24@1224|Proteobacteria,2VM3H@28216|Betaproteobacteria 28216|Betaproteobacteria S replication - - - - - - - - - - - - Phage_GPA k59_1072876_1 1000565.METUNv1_02555 3.55e-87 257.0 COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,2KX5X@206389|Rhodocyclales 206389|Rhodocyclales T Universal stress protein family - - - - - - - - - - - - Usp k59_1072876_2 1000565.METUNv1_02556 3.07e-155 449.0 COG1639@1|root,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,2KVTS@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HDOD k59_287115_1 1000565.METUNv1_01873 2.56e-97 284.0 COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,2VR2C@28216|Betaproteobacteria,2KW8N@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions - - - ko:K02553 - - - - ko00000,ko03019 - - - RraA-like k59_501797_1 311403.Arad_7354 6.58e-12 68.6 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2UP1Q@28211|Alphaproteobacteria,4B7RV@82115|Rhizobiaceae 28211|Alphaproteobacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_394247_1 375286.mma_1946 5.31e-30 108.0 2E793@1|root,331SQ@2|Bacteria,1NBMS@1224|Proteobacteria,2VVZI@28216|Betaproteobacteria,47541@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_394247_2 1095769.CAHF01000006_gene1936 8.46e-50 166.0 COG1718@1|root,COG1718@2|Bacteria,1MXY2@1224|Proteobacteria,2VJ0H@28216|Betaproteobacteria 28216|Betaproteobacteria DT PFAM RIO-like kinase - - 2.7.11.1 ko:K07178 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko01001,ko03009 - - - RIO1 k59_822310_1 497321.C664_16108 3.19e-151 431.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,2KV1W@206389|Rhodocyclales 206389|Rhodocyclales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_37243_1 1121035.AUCH01000001_gene1791 8.19e-22 99.4 COG0642@1|root,COG2770@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_251416_1 1000565.METUNv1_00910 0.0 1191.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,2KU7T@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_964915_1 640081.Dsui_3519 2.6e-17 80.9 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,2KU8G@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_964915_2 85643.Tmz1t_2778 3.88e-33 119.0 COG3308@1|root,COG3308@2|Bacteria,1N1EF@1224|Proteobacteria,2VU3C@28216|Betaproteobacteria,2KWVS@206389|Rhodocyclales 206389|Rhodocyclales S Predicted membrane protein (DUF2069) - - - - - - - - - - - - DUF2069 k59_964915_3 1121004.ATVC01000017_gene1876 1.52e-45 152.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJMC@28216|Betaproteobacteria,2KPNQ@206351|Neisseriales 206351|Neisseriales S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_1072888_1 1000565.METUNv1_00898 1.32e-150 444.0 COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_4,Response_reg k59_1072888_2 1000565.METUNv1_00897 6.35e-56 177.0 COG0745@1|root,COG0745@2|Bacteria,1N8Z8@1224|Proteobacteria,2VW99@28216|Betaproteobacteria 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_323319_1 1349767.GJA_1050 2.63e-100 311.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_72568_1 1056512.D515_02964 2.07e-38 153.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XZWD@135623|Vibrionales 135623|Vibrionales T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - - - - - - - - - - MCPsignal k59_1483_1 62928.azo2482 3.59e-105 351.0 COG0642@1|root,COG3829@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_1483_3 62928.azo2484 7.79e-187 529.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KUMQ@206389|Rhodocyclales 206389|Rhodocyclales T response regulator - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_607753_1 1000565.METUNv1_00799 4.07e-187 532.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,2KU9G@206389|Rhodocyclales 206389|Rhodocyclales H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - - - - - - - - - - - Carb_kinase,YjeF_N k59_822328_1 1452718.JBOY01000180_gene1257 6.01e-12 63.5 COG0389@1|root,COG0389@2|Bacteria 2|Bacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII imuB - 2.7.7.7 ko:K02346,ko:K14161 - - - - ko00000,ko01000,ko03400 - - - IMS k59_180468_1 1500894.JQNN01000001_gene1927 2.91e-44 151.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,473MA@75682|Oxalobacteraceae 28216|Betaproteobacteria D Maf-like protein yceF - - ko:K06287 - - - - ko00000 - - - Maf k59_1037318_1 1000565.METUNv1_02386 1.61e-144 424.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KUBK@206389|Rhodocyclales 206389|Rhodocyclales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_394885_1 883126.HMPREF9710_03413 4.47e-14 71.6 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria,476QP@75682|Oxalobacteraceae 28216|Betaproteobacteria KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_502690_1 1121920.AUAU01000008_gene1560 7.76e-92 287.0 COG1154@1|root,COG1154@2|Bacteria,3Y327@57723|Acidobacteria 57723|Acidobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_608217_1 1000565.METUNv1_03800 8.14e-39 132.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,2KWFM@206389|Rhodocyclales 206389|Rhodocyclales L methyltransferase - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_608217_2 1000565.METUNv1_03799 9.49e-125 366.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,2KV10@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_365358_1 1304883.KI912532_gene1026 3.12e-89 281.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,2KUNW@206389|Rhodocyclales 206389|Rhodocyclales O Cytochrome c ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_656180_1 1549858.MC45_00970 3.93e-13 70.5 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,2K0D6@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the aldehyde dehydrogenase family - - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh k59_656180_2 1090320.KB900605_gene1626 3.01e-46 164.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2K0FF@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the GMC oxidoreductase family - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,Lycopene_cycl k59_8141_2 1392498.JQLH01000001_gene1928 2.38e-76 236.0 2B7JP@1|root,31T6N@2|Bacteria,4NQH3@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_901984_2 640081.Dsui_1784 1.42e-95 288.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,2KW9R@206389|Rhodocyclales 206389|Rhodocyclales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_191594_1 1116472.MGMO_92c00480 1.03e-65 226.0 COG2831@1|root,COG4313@1|root,COG2831@2|Bacteria,COG4313@2|Bacteria,1MXNW@1224|Proteobacteria,1S14R@1236|Gammaproteobacteria,1XGZH@135618|Methylococcales 1236|Gammaproteobacteria CU Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570,Phenol_MetA_deg k59_970744_1 1198452.Jab_2c04390 4.52e-71 222.0 COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,2VRQW@28216|Betaproteobacteria,475R5@75682|Oxalobacteraceae 28216|Betaproteobacteria Q intradiol ring-cleavage dioxygenase - - - - - - - - - - - - Dioxygenase_C k59_150547_1 614083.AWQR01000057_gene3652 6.47e-70 223.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,4AAWR@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_401625_1 159087.Daro_3488 6.66e-97 306.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1043673_1 111105.HR09_09065 3.04e-40 148.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,4NEBW@976|Bacteroidetes,2FMDF@200643|Bacteroidia,22W10@171551|Porphyromonadaceae 976|Bacteroidetes P TrkA C-terminal domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_656212_1 1198452.Jab_2c24550 1.28e-68 216.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VI5H@28216|Betaproteobacteria,474JN@75682|Oxalobacteraceae 28216|Betaproteobacteria EG EamA-like transporter family yijE_1 - - - - - - - - - - - EamA k59_656212_2 760117.JN27_01320 3.05e-06 48.5 COG0122@1|root,COG0122@2|Bacteria,1PDQF@1224|Proteobacteria,2VH56@28216|Betaproteobacteria,473NF@75682|Oxalobacteraceae 28216|Betaproteobacteria L endonuclease III alkA - 3.2.2.21 ko:K01247,ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - AlkA_N,HhH-GPD k59_578009_1 1000565.METUNv1_02106 2.2e-142 406.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KV4Z@206389|Rhodocyclales 206389|Rhodocyclales P Mg2 and Co2 transporter CorC - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_578009_2 1000565.METUNv1_02104 4.06e-87 258.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2VSHV@28216|Betaproteobacteria,2KWFT@206389|Rhodocyclales 206389|Rhodocyclales J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_830348_1 1000565.METUNv1_00356 9.45e-184 525.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,2KV5X@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_864278_1 1396141.BATP01000047_gene3995 1.36e-14 79.3 COG3210@1|root,COG3210@2|Bacteria,46U4I@74201|Verrucomicrobia 74201|Verrucomicrobia U haemagglutination activity domain - - - - - - - - - - - - DUF3739,Haemagg_act k59_935049_1 44689.DDB0233454 5.85e-16 82.8 COG4581@1|root,KOG0947@2759|Eukaryota,3XCS4@554915|Amoebozoa 554915|Amoebozoa A DSHCT - - - ko:K12599 ko03018,map03018 M00392 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,DSHCT,Helicase_C,rRNA_proc-arch k59_295508_1 1100721.ALKO01000022_gene1845 2.47e-37 135.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2VHDV@28216|Betaproteobacteria,4AA6Z@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_295508_2 1276756.AUEX01000003_gene643 1.5e-39 135.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2VR6F@28216|Betaproteobacteria,4ADFU@80864|Comamonadaceae 28216|Betaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_756572_1 1000565.METUNv1_03444 2.35e-126 362.0 COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,2VMZX@28216|Betaproteobacteria,2KW4A@206389|Rhodocyclales 206389|Rhodocyclales T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1113328_1 1000565.METUNv1_00459 9.26e-135 386.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,2KUN1@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_1113328_2 1000565.METUNv1_00458 3.75e-86 255.0 COG0589@1|root,COG0589@2|Bacteria,1NDDA@1224|Proteobacteria,2VUKE@28216|Betaproteobacteria 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_1113328_3 1000565.METUNv1_00457 4.15e-163 467.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KU97@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_401646_1 1357272.AVEO02000145_gene1387 3.49e-15 71.2 28ZJ6@1|root,2ZMAJ@2|Bacteria,1P8MZ@1224|Proteobacteria,1SVPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_721945_1 1000565.METUNv1_02127 1.54e-126 384.0 2EHSE@1|root,33BI5@2|Bacteria,1NIWY@1224|Proteobacteria 1224|Proteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_794466_1 614083.AWQR01000009_gene606 1.29e-81 258.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_794466_2 614083.AWQR01000009_gene605 5.07e-32 121.0 COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,2VIN0@28216|Betaproteobacteria,4ABDM@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM Benzoate membrane transport protein benE - - ko:K05782 - - - - ko00000,ko02000 2.A.46.1 - - BenE k59_334305_1 1000565.METUNv1_01044 7.84e-70 214.0 COG1569@1|root,COG1569@2|Bacteria,1NASM@1224|Proteobacteria,2VVUB@28216|Betaproteobacteria,2KX9H@206389|Rhodocyclales 206389|Rhodocyclales S nucleic acid-binding protein, contains PIN domain - - - - - - - - - - - - PIN_3 k59_191682_1 106648.BBLJ01000001_gene2093 6.93e-113 352.0 COG1028@1|root,COG2030@1|root,COG1028@2|Bacteria,COG2030@2|Bacteria,1MXNQ@1224|Proteobacteria,1S0NX@1236|Gammaproteobacteria,3NR1V@468|Moraxellaceae 1236|Gammaproteobacteria IQ SCP-2 sterol transfer family - - - - - - - - - - - - MaoC_dehydratas,SCP2,adh_short k59_1084654_2 1524467.IV04_10260 3.48e-50 163.0 COG0662@1|root,COG0662@2|Bacteria,1RHRM@1224|Proteobacteria,1S2VE@1236|Gammaproteobacteria,400ZR@613|Serratia 1236|Gammaproteobacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - FdtA k59_612458_1 1000565.METUNv1_01904 5.83e-133 380.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales 28216|Betaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain epsR - - - - - - - - - - - GerE,Response_reg k59_612458_2 1000565.METUNv1_01903 0.000505 42.0 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_864314_1 1000565.METUNv1_02055 3.2e-27 106.0 COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,2WGWG@28216|Betaproteobacteria,2KZQC@206389|Rhodocyclales 206389|Rhodocyclales M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_864314_2 1000565.METUNv1_02054 2.59e-60 187.0 COG2246@1|root,COG2246@2|Bacteria,1PT5N@1224|Proteobacteria,2WAEB@28216|Betaproteobacteria,2KZM5@206389|Rhodocyclales 206389|Rhodocyclales S GtrA-like protein - - - - - - - - - - - - GtrA k59_794492_1 1267211.KI669560_gene2795 1e-68 213.0 COG0782@1|root,COG0782@2|Bacteria,4NNH6@976|Bacteroidetes,1IS01@117747|Sphingobacteriia 976|Bacteroidetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_513043_1 1000565.METUNv1_00086 4.38e-69 217.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2VK1G@28216|Betaproteobacteria,2KW3H@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_542678_1 522306.CAP2UW1_1626 2.23e-210 598.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VJQV@28216|Betaproteobacteria 28216|Betaproteobacteria IQ amp-dependent synthetase and ligase fadD - - - - - - - - - - - AMP-binding,AMP-binding_C k59_513069_1 314278.NB231_14643 1.83e-39 149.0 COG0834@1|root,COG2199@1|root,COG0834@2|Bacteria,COG3706@2|Bacteria,1PF69@1224|Proteobacteria,1RWSW@1236|Gammaproteobacteria,1X15K@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1113369_1 243159.AFE_1499 7.85e-113 338.0 COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,1S0WH@1236|Gammaproteobacteria,2NDQV@225057|Acidithiobacillales 225057|Acidithiobacillales O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_295571_1 391735.Veis_0459 4.15e-78 259.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria,2W9Z8@28216|Betaproteobacteria,4AHQE@80864|Comamonadaceae 28216|Betaproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_1043730_1 1122604.JONR01000004_gene788 8.12e-39 140.0 COG3315@1|root,COG3315@2|Bacteria,1RCET@1224|Proteobacteria,1S2A1@1236|Gammaproteobacteria,1X7P4@135614|Xanthomonadales 135614|Xanthomonadales Q Leucine carboxyl methyltransferase - - - - - - - - - - - - LCM k59_542694_1 614083.AWQR01000055_gene1989 6.03e-105 309.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,4A9X7@80864|Comamonadaceae 28216|Betaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_513080_1 1121920.AUAU01000026_gene1449 4.48e-59 189.0 COG0566@1|root,COG0566@2|Bacteria,3Y4GM@57723|Acidobacteria 57723|Acidobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_902078_1 1122951.ATUE01000006_gene1255 3.12e-46 160.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,3NIQM@468|Moraxellaceae 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1113378_1 1000565.METUNv1_02022 8.86e-53 183.0 COG2199@1|root,COG2199@2|Bacteria,1R3R8@1224|Proteobacteria,2VJND@28216|Betaproteobacteria,2KWP3@206389|Rhodocyclales 206389|Rhodocyclales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_220088_1 1100721.ALKO01000003_gene1999 1.07e-31 121.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,4AAFV@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_220088_2 543728.Vapar_3504 4.14e-83 264.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,4AC2I@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM NADH-quinone oxidoreductase, chain G nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_80198_1 1000565.METUNv1_01187 6.34e-295 808.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KUIZ@206389|Rhodocyclales 206389|Rhodocyclales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_115023_1 322710.Avin_11380 6.17e-05 44.7 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1RS29@1236|Gammaproteobacteria 1236|Gammaproteobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14,6.4.1.6 ko:K01474,ko:K10854 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_115023_2 748247.AZKH_3166 1.05e-71 234.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,2KYK0@206389|Rhodocyclales 206389|Rhodocyclales J Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.14,6.4.1.8 ko:K01473,ko:K10701 ko00330,ko00642,ko01100,ko01120,ko01220,map00330,map00642,map01100,map01120,map01220 - R03187,R05453 RC00040,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_472854_1 395494.Galf_1991 1.51e-84 257.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,44VFG@713636|Nitrosomonadales 28216|Betaproteobacteria E Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_472854_2 1123354.AUDR01000017_gene115 8.01e-29 114.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,1KRJ2@119069|Hydrogenophilales 119069|Hydrogenophilales E Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_935108_1 863365.XHC_2697 2.59e-124 361.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,1X3K9@135614|Xanthomonadales 135614|Xanthomonadales C NADH flavin oxidoreductase NADH oxidase - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_656361_1 1307761.L21SP2_2090 3.43e-91 275.0 COG3177@1|root,COG3177@2|Bacteria,2J7GE@203691|Spirochaetes 203691|Spirochaetes S Fic DOC family - - - - - - - - - - - - Fic,Fic_N k59_115026_1 365044.Pnap_3900 2.81e-43 157.0 COG1538@1|root,COG1538@2|Bacteria,1P0S2@1224|Proteobacteria,2VH06@28216|Betaproteobacteria,4AAJB@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family tolC2 - - - - - - - - - - - OEP k59_366437_1 159087.Daro_2841 2e-62 214.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KY8W@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_970841_1 395495.Lcho_1202 2.07e-41 139.0 2DN6G@1|root,32VT3@2|Bacteria,1MZVT@1224|Proteobacteria,2VSJH@28216|Betaproteobacteria 28216|Betaproteobacteria S NIPSNAP family containing protein - - - - - - - - - - - - NIPSNAP k59_970841_2 365044.Pnap_2712 0.000157 44.7 COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2VMQ5@28216|Betaproteobacteria,4AJ1X@80864|Comamonadaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_366444_1 614083.AWQR01000018_gene1872 5.92e-17 80.1 COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,2VK22@28216|Betaproteobacteria,4AC1D@80864|Comamonadaceae 28216|Betaproteobacteria T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_472871_1 1000565.METUNv1_01876 6.55e-125 370.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,2KVUU@206389|Rhodocyclales 206389|Rhodocyclales C Malate synthase - - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1084777_1 358220.C380_03225 4.39e-15 75.1 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,4AA5Y@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM type I secretion membrane fusion protein, HlyD family - - - ko:K02022,ko:K12537 - M00328 - - ko00000,ko00002,ko02000,ko02044 8.A.1 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1084777_2 1390370.O203_18185 2.5e-59 201.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,1T1HR@1236|Gammaproteobacteria,1YCYE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria V ABC transporter transmembrane region - - - ko:K06148,ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1,3.A.1.110 - - ABC_membrane,ABC_tran k59_472878_1 1000565.METUNv1_00265 7.35e-101 313.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales 206389|Rhodocyclales C Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_513144_1 583355.Caka_0712 5.29e-13 70.1 COG0617@1|root,COG0617@2|Bacteria,46UER@74201|Verrucomicrobia,3K732@414999|Opitutae 414999|Opitutae J Polynucleotide adenylyltransferase - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_513144_2 1288963.ADIS_2900 1.32e-08 57.8 COG1413@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2133@2|Bacteria,4NFBQ@976|Bacteroidetes,47NAW@768503|Cytophagia 976|Bacteroidetes CG Cytochrome c - - - - - - - - - - - - Cytochrom_C,GSDH,HEAT_2,HEAT_PBS k59_542727_1 522306.CAP2UW1_4237 9.98e-65 224.0 COG2304@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2VTFV@28216|Betaproteobacteria 28216|Betaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347,HemolysinCabind k59_80228_1 266264.Rmet_5114 3.82e-53 182.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,1K4X3@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_334457_1 1392838.AWNM01000025_gene4193 1.92e-51 164.0 COG1961@1|root,COG1961@2|Bacteria,1PI1N@1224|Proteobacteria,2WA3H@28216|Betaproteobacteria,3T8AZ@506|Alcaligenaceae 28216|Betaproteobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - - k59_334457_2 1348657.M622_03290 3.15e-62 193.0 COG3153@1|root,COG3153@2|Bacteria,1QUSG@1224|Proteobacteria,2VKN1@28216|Betaproteobacteria,2KW27@206389|Rhodocyclales 206389|Rhodocyclales S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_442137_1 1000565.METUNv1_01859 6.27e-175 514.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_80230_1 243231.GSU2581 1.07e-07 56.2 COG2204@1|root,COG2204@2|Bacteria,1NR02@1224|Proteobacteria,42Y6M@68525|delta/epsilon subdivisions,2WU28@28221|Deltaproteobacteria,43TU1@69541|Desulfuromonadales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_756665_1 296591.Bpro_4468 5.88e-62 208.0 COG4389@1|root,COG4389@2|Bacteria,1MWEH@1224|Proteobacteria,2VIZV@28216|Betaproteobacteria,4AC23@80864|Comamonadaceae 28216|Betaproteobacteria L site-specific recombinase - - - - - - - - - - - - SpecificRecomb k59_794593_1 535289.Dtpsy_3255 6.27e-91 272.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,4AASI@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_21,rve,rve_3 k59_259137_1 1304883.KI912532_gene2345 5.58e-87 257.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,2KWKP@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_1084821_1 1276756.AUEX01000014_gene2965 5.24e-202 569.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,4AAN9@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_44805_1 1000565.METUNv1_03052 6.36e-101 295.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,2KVN5@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the UPF0301 (AlgH) family algH - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_44805_2 1000565.METUNv1_03051 1.46e-44 147.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,2KWP7@206389|Rhodocyclales 206389|Rhodocyclales J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_685453_2 305700.B447_20393 7.74e-55 190.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,2KUZT@206389|Rhodocyclales 206389|Rhodocyclales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_1113431_1 1000565.METUNv1_03593 2.33e-111 328.0 COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2VKGI@28216|Betaproteobacteria,2KW58@206389|Rhodocyclales 206389|Rhodocyclales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_220141_1 84531.JMTZ01000012_gene2919 2.95e-51 169.0 COG5642@1|root,COG5642@2|Bacteria,1N15N@1224|Proteobacteria,1TBN3@1236|Gammaproteobacteria,1X972@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_220141_2 1123487.KB892864_gene2100 4.56e-37 128.0 COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,2VSA9@28216|Betaproteobacteria,2KZUY@206389|Rhodocyclales 206389|Rhodocyclales S RES - - - - - - - - - - - - RES k59_401762_1 338969.Rfer_4055 5.81e-47 172.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4AD7J@80864|Comamonadaceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9,dCache_1 k59_193154_1 1123392.AQWL01000001_gene1676 2.93e-130 390.0 COG0210@1|root,COG0210@2|Bacteria,1MWW6@1224|Proteobacteria,2VM7D@28216|Betaproteobacteria,1KTI1@119069|Hydrogenophilales 119069|Hydrogenophilales L UvrD-like helicase C-terminal domain - - - - - - - - - - - - UvrD_C k59_578710_1 375286.mma_1519 1.68e-20 86.7 COG0526@1|root,COG0526@2|Bacteria,1N8B0@1224|Proteobacteria,2VW5T@28216|Betaproteobacteria,474I4@75682|Oxalobacteraceae 28216|Betaproteobacteria CO Thioredoxin - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Thioredoxin k59_1057325_2 338969.Rfer_1339 2.69e-73 220.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,4ADXV@80864|Comamonadaceae 28216|Betaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_553855_1 1000565.METUNv1_01853 1.07e-217 609.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,2KVEX@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_161562_1 1294143.H681_04945 2.51e-63 216.0 2BDIH@1|root,3277R@2|Bacteria,1N3VW@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_529867_1 293826.Amet_2994 1.01e-21 99.4 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,36FK8@31979|Clostridiaceae 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_695326_1 794903.OPIT5_10800 1.04e-72 235.0 COG0807@1|root,COG0807@2|Bacteria 2|Bacteria H GTP cyclohydrolase II activity ribA - 3.5.4.25,4.1.99.12 ko:K01497,ko:K14652 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 k59_876513_2 1000565.METUNv1_02459 3.36e-33 130.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,2VX93@28216|Betaproteobacteria,2KXPI@206389|Rhodocyclales 206389|Rhodocyclales S TPR repeat - - - - - - - - - - - - TPR_16,TPR_8 k59_555105_1 527002.yaldo0001_13280 2.06e-10 62.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RZN7@1236|Gammaproteobacteria,41EMY@629|Yersinia 1236|Gammaproteobacteria T to hybrid sensory histidine kinase in two-component regulatory system with EvgA PRK09959 bvgS - 2.7.13.3 ko:K07679 ko02020,ko05133,map02020,map05133 M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg,SBP_bac_3 k59_485091_1 29581.BW37_00652 1.26e-150 437.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4725T@75682|Oxalobacteraceae 28216|Betaproteobacteria JKL Belongs to the DEAD box helicase family rhlE2 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_460030_1 1304883.KI912532_gene806 4.65e-91 282.0 COG2801@1|root,COG2801@2|Bacteria,1MXCK@1224|Proteobacteria,2VK4Q@28216|Betaproteobacteria,2KWIR@206389|Rhodocyclales 206389|Rhodocyclales L Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - Mu-transpos_C,rve k59_674752_1 29581.BW37_02804 1.12e-82 249.0 COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,2VQHV@28216|Betaproteobacteria,4747T@75682|Oxalobacteraceae 28216|Betaproteobacteria O Glutathione peroxidase - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_209166_1 694427.Palpr_1224 2.21e-52 170.0 COG0290@1|root,COG0290@2|Bacteria,4NIZ5@976|Bacteroidetes,2FNF1@200643|Bacteroidia,22X5B@171551|Porphyromonadaceae 976|Bacteroidetes J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_841610_1 1000565.METUNv1_01488 2.26e-138 433.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,2KVQ5@206389|Rhodocyclales 206389|Rhodocyclales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl k59_732805_2 1229205.BUPH_02464 1.55e-64 205.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHC7@28216|Betaproteobacteria,1KGS4@119060|Burkholderiaceae 28216|Betaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_352756_1 543728.Vapar_2162 1.27e-44 160.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,4A9W9@80864|Comamonadaceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1019592_1 666681.M301_0673 2.85e-16 78.2 COG0265@1|root,COG0265@2|Bacteria,1RDHW@1224|Proteobacteria,2VRY7@28216|Betaproteobacteria,2KMG9@206350|Nitrosomonadales 206350|Nitrosomonadales O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_162534_1 1286632.P278_18520 2.65e-09 54.7 COG2388@1|root,COG2388@2|Bacteria,4NUS6@976|Bacteroidetes,1I57A@117743|Flavobacteriia 976|Bacteroidetes S (GNAT) family - - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG k59_162534_2 868131.MSWAN_1308 2.32e-13 73.6 COG0642@1|root,COG3920@1|root,arCOG02327@2157|Archaea,arCOG02335@2157|Archaea 2157|Archaea T PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor - - - - - - - - - - - - BAT,GAF,GAF_2,HATPase_c,HTH_10,HisKA,HisKA_2,HisKA_7TM,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_162536_1 1000565.METUNv1_00863 3.8e-113 329.0 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,2VH23@28216|Betaproteobacteria,2KVHY@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0246 family - - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_378748_1 614083.AWQR01000022_gene17 2.44e-58 192.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,4A9Z8@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily lplT - - - - - - - - - - - MFS_1 k59_460079_1 426114.THI_2539 3.95e-69 215.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,1KMWZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - IstB_IS21 k59_1123620_2 1000565.METUNv1_01434 1.37e-97 313.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,2KUWB@206389|Rhodocyclales 206389|Rhodocyclales C FAD linked oxidase - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_911729_1 518766.Rmar_0343 8.03e-26 112.0 COG0840@1|root,COG3292@1|root,COG0840@2|Bacteria,COG3292@2|Bacteria,4NK8Q@976|Bacteroidetes 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - GAF_2,GerE,HATPase_c,Reg_prop,SpoIIE,Y_Y_Y k59_1019627_1 1123052.AUDF01000009_gene1650 1.58e-53 177.0 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FMIB@85023|Microbacteriaceae 201174|Actinobacteria L Phage integrase, N-terminal SAM-like domain xerD GO:0008150,GO:0040007 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1019627_2 1223523.H340_29229 3.27e-13 66.6 2E3JK@1|root,32YHZ@2|Bacteria,2GS0Y@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_90986_1 935863.AWZR01000001_gene1770 3.16e-13 70.9 28IAG@1|root,2Z8D2@2|Bacteria,1P5EH@1224|Proteobacteria,1RYCA@1236|Gammaproteobacteria,1X50Q@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4129) - - - - - - - - - - - - DUF4129 k59_90986_2 686578.AFFX01000004_gene3683 2.12e-45 157.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - SpoIIM k59_981680_1 279238.Saro_3003 3.56e-55 195.0 28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,2TST4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_1059010_1 1458275.AZ34_07875 2.19e-51 178.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,4ABC8@80864|Comamonadaceae 28216|Betaproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - - - - - - - - - - - Carb_kinase,YjeF_N k59_1059021_1 1166018.FAES_2694 2.56e-66 218.0 COG3637@1|root,COG3637@2|Bacteria,4PM31@976|Bacteroidetes,47KS5@768503|Cytophagia 976|Bacteroidetes M SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_162574_1 1125971.ASJB01000042_gene3432 5.87e-32 130.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4DXHP@85010|Pseudonocardiales 201174|Actinobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1019640_2 1000565.METUNv1_03761 3.51e-258 711.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VHM2@28216|Betaproteobacteria,2KVFD@206389|Rhodocyclales 206389|Rhodocyclales M PEP-CTERM exosortase 1-associated glycosyltransferase, Daro_2409 family protein - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1 k59_1019640_3 1000565.METUNv1_03759 5.87e-12 65.1 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,2KUED@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_162577_1 984262.SGRA_0367 8.12e-43 159.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,1IW7P@117747|Sphingobacteriia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_555190_1 390235.PputW619_0610 1.1e-77 246.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1YVAD@136845|Pseudomonas putida group 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280 Aldedh k59_271214_1 1121035.AUCH01000014_gene2378 2.51e-120 370.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_531721_1 748247.AZKH_p0160 8.3e-54 177.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,2KXZZ@206389|Rhodocyclales 206389|Rhodocyclales C NADH:flavin oxidoreductase / NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_378828_1 338969.Rfer_0102 3.51e-90 268.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,4AB2H@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM LemA family protein lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_981717_1 396588.Tgr7_0417 6.98e-47 156.0 COG4396@1|root,COG4396@2|Bacteria,1REDK@1224|Proteobacteria,1S3XY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage host-nuclease inhibitor protein Gam gam - - - - - - - - - - - Phage_Mu_Gam k59_981717_2 76114.ebA2982 3.07e-29 114.0 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,2KVYJ@206389|Rhodocyclales 206389|Rhodocyclales L May be involved in recombination rdgC - - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_411249_1 1000565.METUNv1_02113 3.52e-76 228.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,2KWC1@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_411249_2 1000565.METUNv1_02112 2.13e-159 449.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2VNC5@28216|Betaproteobacteria,2KWES@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1059071_1 614083.AWQR01000009_gene750 2.66e-132 403.0 COG0550@1|root,COG5531@1|root,COG0550@2|Bacteria,COG5531@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,4AAE2@80864|Comamonadaceae 28216|Betaproteobacteria L DNA topoisomerase, type IA, central domain protein topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_1059071_2 365046.Rta_37520 3.12e-66 204.0 COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,4ADR1@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM nuclear protein SET - - - ko:K07117 - - - - ko00000 - - - SET k59_209330_1 592015.HMPREF1705_00603 2.81e-56 185.0 COG0177@1|root,COG0177@2|Bacteria 2|Bacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K07457,ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_674936_1 381666.H16_A2653 2.31e-18 80.9 COG3663@1|root,COG3663@2|Bacteria,1RGEZ@1224|Proteobacteria,2VRU0@28216|Betaproteobacteria,1KI4J@119060|Burkholderiaceae 28216|Betaproteobacteria L Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG k59_674936_2 1198452.Jab_2c30060 3.65e-26 107.0 COG3391@1|root,COG3391@2|Bacteria,1NT8H@1224|Proteobacteria,2W119@28216|Betaproteobacteria 28216|Betaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - - k59_841754_2 614083.AWQR01000010_gene1578 2.87e-82 253.0 COG0834@1|root,COG0834@2|Bacteria,1RJAC@1224|Proteobacteria,2VU45@28216|Betaproteobacteria 28216|Betaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_841758_1 1397527.Q670_05265 4.33e-80 262.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1XHZT@135619|Oceanospirillales 135619|Oceanospirillales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_209359_1 1215092.PA6_009_00300 8.13e-57 188.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria,1S6FI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_587295_1 1000565.METUNv1_03750 1.23e-42 148.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VJEB@28216|Betaproteobacteria,2KUMI@206389|Rhodocyclales 206389|Rhodocyclales D COG0489 ATPases involved in chromosome partitioning - - 2.7.10.1 ko:K08252 - - - - ko00000,ko01000 - - - AAA_31 k59_56032_1 614083.AWQR01000021_gene260 1.01e-126 376.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,4AAVU@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_162634_1 1538295.JY96_16500 1.76e-68 214.0 2BIUT@1|root,32D2T@2|Bacteria,1PZRJ@1224|Proteobacteria,2W489@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_162635_1 1502851.FG93_03272 1.36e-05 44.3 COG4691@1|root,COG4691@2|Bacteria,1NP6E@1224|Proteobacteria,2UKV5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Plasmid stability protein - - - ko:K21495 - - - - ko00000,ko02048 - - - - k59_674973_1 375286.mma_3152 8.27e-56 185.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4728E@75682|Oxalobacteraceae 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_876676_1 1095769.CAHF01000011_gene2360 3.9e-56 188.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,472I1@75682|Oxalobacteraceae 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - EAL,HDOD k59_674975_2 1144343.PMI41_00452 2.67e-14 70.9 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2U94I@28211|Alphaproteobacteria,43K26@69277|Phyllobacteriaceae 28211|Alphaproteobacteria N Belongs to the flagella basal body rod proteins family flgC GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1093942_2 242527.Q6V7N8_9CAUD 5.87e-39 139.0 4QBQ9@10239|Viruses,4QVS0@35237|dsDNA viruses no RNA stage,4QPFB@28883|Caudovirales,4QNDC@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF4043) - - - - - - - - - - - - - k59_531817_1 640081.Dsui_1373 1.54e-81 270.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales 206389|Rhodocyclales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_91107_1 29581.BW37_02699 9.8e-29 118.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,476IJ@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain yfhK - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1059143_1 1379858.N508_00451 2.91e-24 105.0 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,Terminase_3,Terminase_6 k59_1059143_2 1187851.A33M_3334 1.52e-17 79.7 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,2UDZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1059148_1 748247.AZKH_4081 2.94e-113 337.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,2VJ11@28216|Betaproteobacteria,2KVBY@206389|Rhodocyclales 206389|Rhodocyclales C Nitrogenase component 1 type Oxidoreductase - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_162650_1 1112274.KI911560_gene1251 6e-30 121.0 2DNAT@1|root,32WH7@2|Bacteria,1QWGY@1224|Proteobacteria,2WGZE@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_806536_1 1286631.X805_30790 3.06e-23 96.7 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,1KIZ7@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_806536_2 232721.Ajs_2755 5.17e-26 103.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,4A9YA@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red k59_1019772_1 379731.PST_1969 7.52e-66 223.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Z1ZF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T Sensory box protein - - - - - - - - - - - - 5TM-5TMR_LYT,CHASE,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_555306_1 1000565.METUNv1_02451 1.76e-124 378.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_675020_1 1182590.BN5_03332 4.2e-81 263.0 28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,1RPFU@1236|Gammaproteobacteria,1YJ56@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_981784_1 335284.Pcryo_2333 2.77e-129 376.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,3NJCY@468|Moraxellaceae 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_230998_1 1547437.LL06_10350 4.32e-94 287.0 COG0583@1|root,COG0583@2|Bacteria,1QU1H@1224|Proteobacteria,2U3KJ@28211|Alphaproteobacteria,43K86@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate ## 12919 queries scanned ## Total time (seconds): 116.94383430480957 ## Rate: 110.47 q/s