## Sat Jan 4 12:39:41 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA437562/SRR6820486/SRR6820486_p_cluster_rep_seq.fasta --output PRJNA437562_SRR6820486 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_14074_1 1385658.U5KNR1_9VIRU 2.83e-56 193.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_14074_3 1385658.U5KPZ6_9VIRU 1.67e-225 639.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_14074_4 1986029.Q9MBM7_9VIRU 1.47e-13 74.3 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_203488_1 1158609.I586_02159 6.79e-12 74.7 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HDG6@91061|Bacilli,4B4IE@81852|Enterococcaceae 91061|Bacilli L Phage integrase, N-terminal SAM-like domain int7 - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase k59_378562_1 435830.HMPREF0045_01783 2.72e-32 130.0 COG0517@1|root,COG1082@1|root,COG2089@1|root,COG0517@2|Bacteria,COG1082@2|Bacteria,COG2089@2|Bacteria,2GJC9@201174|Actinobacteria 201174|Actinobacteria M synthase - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - AP_endonuc_2,CBS,NeuB,SAF k59_378562_2 351160.RCIX204 1.2e-94 286.0 COG1089@1|root,arCOG01373@2157|Archaea,2XUVY@28890|Euryarchaeota,2N9AM@224756|Methanomicrobia 224756|Methanomicrobia M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_162530_2 1618248.A0A0C5IB82_9CIRC 3.12e-83 259.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_311240_2 1517681.HW45_04125 7.89e-12 66.2 2DDKV@1|root,32U1R@2|Bacteria,1N5SP@1224|Proteobacteria,1SAQN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Peptidase_M15_3 k59_391907_2 641112.ACOK01000115_gene2244 1.08e-07 55.1 COG1961@1|root,COG1961@2|Bacteria,1UZT3@1239|Firmicutes,25BHM@186801|Clostridia 186801|Clostridia L Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_175785_1 435590.BVU_2827 2.26e-14 76.3 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4PMTY@976|Bacteroidetes,2FRJ0@200643|Bacteroidia,4AQDD@815|Bacteroidaceae 976|Bacteroidetes D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_324432_1 198214.SF1545 2.89e-29 108.0 COG4570@1|root,COG4570@2|Bacteria,1N92D@1224|Proteobacteria,1SDZ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC - - 3.1.22.4 ko:K01160 - - - - ko00000,ko01000,ko03400 - - - RusA k59_391917_3 640513.Entas_1117 4.37e-13 68.9 COG3969@1|root,COG3969@2|Bacteria,1NBDM@1224|Proteobacteria,1RYRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoadenosine phosphosulfate ybdN - - - - - - - - - - - DUF3440,PAPS_reduct k59_351512_1 1121286.AUMT01000001_gene60 4.77e-12 69.7 29FGV@1|root,302EG@2|Bacteria,4PJGH@976|Bacteroidetes,1I8PA@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_520_1 1341157.RF007C_02805 1.47e-78 267.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,3WHUH@541000|Ruminococcaceae 186801|Clostridia L Psort location Cytoplasmic, score - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_520_2 619693.HMPREF6745_2501 3.42e-47 158.0 COG1041@1|root,COG1041@2|Bacteria,4NVFF@976|Bacteroidetes,2FSHI@200643|Bacteroidia 976|Bacteroidetes L Methyltransferase domain - - - - - - - - - - - - - k59_324434_1 765698.Mesci_3819 8.94e-37 132.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_108560_1 57918.XP_004310191.1 0.000668 44.3 COG0514@1|root,KOG0351@2759|Eukaryota,37NB9@33090|Viridiplantae,3GAVC@35493|Streptophyta,4JFJC@91835|fabids 35493|Streptophyta A ATP-dependent DNA helicase - GO:0000724,GO:0000725,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006284,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009378,GO:0009414,GO:0009415,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0042631,GO:0043138,GO:0043140,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0070887,GO:0071103,GO:0071214,GO:0071229,GO:0071462,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0104004,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:1901700,GO:1901701 3.6.4.12 ko:K10730 - - - - ko00000,ko01000,ko03032,ko03400 - - - DEAD,Helicase_C k59_365120_2 1097668.BYI23_B004530 7.09e-26 110.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2VNV4@28216|Betaproteobacteria,1K7AD@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM RecT protein recT - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_314063_2 691965.D4P7I8_9CAUD 4.2e-57 184.0 4QGJH@10239|Viruses,4QZ35@35237|dsDNA viruses no RNA stage,4QRZS@28883|Caudovirales,4QMAA@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_314063_4 691965.D4P7I3_9CAUD 5.29e-57 199.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_205612_1 1692246.A0A0K1RL26_9CIRC 4.09e-08 61.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_16160_3 691965.D4P7I0_9CAUD 2.27e-60 201.0 4QDSZ@10239|Viruses,4QXJ8@35237|dsDNA viruses no RNA stage,4QPKE@28883|Caudovirales,4QM8R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_393656_1 1121020.JIAG01000002_gene781 4.8e-05 54.7 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria 201174|Actinobacteria P PFAM PKD domain containing protein wcoG - - - - - - - - - - - Laminin_G_3,PKD k59_286013_2 1150399.AQYK01000001_gene262 2.99e-16 77.0 COG1054@1|root,COG1054@2|Bacteria,2GMMP@201174|Actinobacteria,4FKV8@85023|Microbacteriaceae 201174|Actinobacteria S Rhodanase C-terminal - - - ko:K07146 - - - - ko00000 - - - Rhodanese,Rhodanese_C k59_110677_1 1423775.BAMN01000009_gene387 4.02e-33 140.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,4IU4Q@91061|Bacilli,3FC2A@33958|Lactobacillaceae 91061|Bacilli S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_286016_1 1122991.BAIZ01000025_gene1859 2.18e-46 164.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia 976|Bacteroidetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_138575_1 1123504.JQKD01000021_gene5682 7.46e-38 145.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_393839_2 36875.HQ29_07075 8.42e-44 159.0 COG0467@1|root,COG0467@2|Bacteria,4NIAQ@976|Bacteroidetes,2FMJT@200643|Bacteroidia,22W0G@171551|Porphyromonadaceae 976|Bacteroidetes T AAA domain - - - - - - - - - - - - AAA_25 k59_205950_2 111781.Lepto7376_2186 2.25e-08 56.2 COG4627@1|root,COG4627@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - BON,Glycos_transf_2,Methyltransf_11 k59_245808_1 1692253.A0A0K1RLM4_9CIRC 2.31e-21 99.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_16417_1 1033743.CAES01000020_gene3130 1.49e-33 137.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HEHJ@91061|Bacilli 91061|Bacilli D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_247317_1 118168.MC7420_7754 8.09e-05 48.5 COG0457@1|root,COG0457@2|Bacteria,1G33Z@1117|Cyanobacteria,1HEGD@1150|Oscillatoriales 1117|Cyanobacteria S CHAT domain - - - - - - - - - - - - CHAT,NACHT,NB-ARC,TPR_12,TPR_7,TPR_8 k59_58829_1 515635.Dtur_0402 2.27e-21 97.4 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - - - - - - - - - - - Collagen_bind_2,DUF4038,RicinB_lectin_2 k59_421973_1 388051.AUFE01000035_gene4020 8.82e-44 156.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_193022_6 498211.CJA_0589 8.19e-15 86.3 COG2982@1|root,COG2982@2|Bacteria,1QVU8@1224|Proteobacteria,1T2J0@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - He_PIG,OMP_b-brl k59_208074_1 926549.KI421517_gene2353 2.49e-77 272.0 COG3378@1|root,COG5545@1|root,COG3378@2|Bacteria,COG5545@2|Bacteria,4PP9A@976|Bacteroidetes 976|Bacteroidetes S Phage plasmid primase P4 family - - - - - - - - - - - - VirE_N k59_112184_3 1244856.K4PWR5_9CAUD 1.25e-53 190.0 4QEDJ@10239|Viruses,4QZ5Q@35237|dsDNA viruses no RNA stage,4QPM4@28883|Caudovirales,4QP27@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_409494_1 67275.JOAP01000001_gene2816 3.23e-22 102.0 COG1372@1|root,COG3505@1|root,COG1372@2|Bacteria,COG3505@2|Bacteria,2IAUZ@201174|Actinobacteria 201174|Actinobacteria U Type IV secretory system Conjugative DNA transfer - - - - - - - - - - - - T4SS-DNA_transf k59_343221_1 2003327.CAPSD_BPCHP 1.83e-18 89.7 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_86443_1 1498011.A0A096XUS7_9CAUD 9.74e-44 165.0 4QAUF@10239|Viruses,4QQIV@28883|Caudovirales,4QNZ6@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_261266_1 272943.RSP_3791 0.000152 51.6 COG1196@1|root,COG1196@2|Bacteria,1R5PN@1224|Proteobacteria,2U1U2@28211|Alphaproteobacteria,1FCIV@1060|Rhodobacter 28211|Alphaproteobacteria D IMG reference gene - - - - - - - - - - - - - k59_263093_1 435590.BVU_2827 8.74e-39 150.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4PMTY@976|Bacteroidetes,2FRJ0@200643|Bacteroidia,4AQDD@815|Bacteroidaceae 976|Bacteroidetes D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_358722_2 680198.SCAB_60541 8.68e-19 85.1 COG4570@1|root,COG4570@2|Bacteria,2GV9V@201174|Actinobacteria 201174|Actinobacteria L Endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_318707_1 1185876.BN8_03672 1.46e-08 64.7 COG2755@1|root,COG3064@1|root,COG4675@1|root,COG2755@2|Bacteria,COG3064@2|Bacteria,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein sprF - - ko:K18546 - - - - ko00000,ko01000,ko01002 - - - Pro_Al_protease,Trypsin k59_33900_1 591157.SSLG_03431 1.71e-17 81.6 COG0270@1|root,COG0270@2|Bacteria,2I8R8@201174|Actinobacteria 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_126695_4 928210.CALU01000010_gene852 6.72e-18 89.7 COG4675@1|root,COG4675@2|Bacteria,1N0FZ@1224|Proteobacteria,2VFMC@28211|Alphaproteobacteria,48UPF@772|Bartonellaceae 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_126695_7 883.DvMF_1643 8.21e-14 81.6 COG3941@1|root,COG3941@2|Bacteria,1RM44@1224|Proteobacteria,42YXN@68525|delta/epsilon subdivisions,2WUIP@28221|Deltaproteobacteria,2MBZS@213115|Desulfovibrionales 28221|Deltaproteobacteria S tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_33915_1 12336.Q331Y3_CBCP 2.38e-43 162.0 4QDSM@10239|Viruses,4QUNV@35237|dsDNA viruses no RNA stage,4QSR0@28883|Caudovirales,4QKBR@10662|Myoviridae 10662|Myoviridae S RRXRR protein - - - - - - - - - - - - - k59_359071_1 1410624.JNKK01000065_gene1264 2.33e-17 88.6 2BJ9Z@1|root,32DJR@2|Bacteria,1UP8S@1239|Firmicutes,25H90@186801|Clostridia,27Q6K@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - k59_319121_1 118797.XP_007446525.1 1.09e-60 205.0 COG0468@1|root,KOG1433@2759|Eukaryota,3AI1H@33154|Opisthokonta,3BXPE@33208|Metazoa,3DE5Z@33213|Bilateria 33208|Metazoa L Mitochondrial DNA repair protein recA homolog - - - - - - - - - - - - RecA k59_413771_1 1237149.C900_05366 3.63e-07 58.2 COG3740@1|root,COG3740@2|Bacteria,4NDXV@976|Bacteroidetes,47V54@768503|Cytophagia 976|Bacteroidetes S Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_306033_1 644548.SCNU_20077 1.02e-21 97.4 COG4695@1|root,COG4695@2|Bacteria,2IJHD@201174|Actinobacteria 201174|Actinobacteria S Portal protein - - - - - - - - - - - - Phage_portal k59_348013_1 1206720.BAFQ01000125_gene3146 9.46e-12 70.9 COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4FWEG@85025|Nocardiaceae 201174|Actinobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - DUF3670,Helicase_C,SNF2_N k59_147653_1 754476.Q7A_657 6.71e-07 55.1 COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,4606T@72273|Thiotrichales 72273|Thiotrichales L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_221953_2 622312.ROSEINA2194_01264 1.54e-55 183.0 COG0270@1|root,COG0270@2|Bacteria,1VSZI@1239|Firmicutes,24YBG@186801|Clostridia 186801|Clostridia L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_221953_5 140626.JHWB01000009_gene1075 1.89e-08 58.5 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_413782_1 1246459.KB898363_gene3130 1.17e-63 217.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,1R7CK@1224|Proteobacteria,2U228@28211|Alphaproteobacteria,4BN0G@82115|Rhizobiaceae 28211|Alphaproteobacteria KL DNA methylase N-4 - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_372324_1 231434.JQJH01000012_gene2820 2.81e-11 68.6 COG0459@1|root,COG0459@2|Bacteria,1R575@1224|Proteobacteria,2TQUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_36558_1 1165094.RINTHH_3920 9.89e-43 152.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_306306_1 10752.PORTL_BPN4 3.82e-25 108.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_103820_2 760568.Desku_1084 3.58e-18 88.6 COG4974@1|root,COG4974@2|Bacteria,1UA9R@1239|Firmicutes,248Z8@186801|Clostridia,2648Q@186807|Peptococcaceae 186801|Clostridia L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_integrase k59_322512_1 768486.EHR_09620 0.000163 47.8 COG5280@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,4HGP4@91061|Bacilli,4B1AH@81852|Enterococcaceae 91061|Bacilli S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_147957_1 861208.AGROH133_06202 5.64e-30 122.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_384619_1 582402.Hbal_1042 8.47e-30 117.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,43XP6@69657|Hyphomonadaceae 28211|Alphaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_292198_1 1005994.GTGU_01788 1.85e-37 139.0 COG4643@1|root,COG4643@2|Bacteria,1MW9E@1224|Proteobacteria,1RXXG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zinc-binding domain of primase-helicase - - - ko:K06919 - - - - ko00000 - - - Prim_Zn_Ribbon,Toprim_3 k59_348328_3 5762.XP_002682047.1 2.47e-19 91.7 2CJ6N@1|root,2S3SZ@2759|Eukaryota 5762.XP_002682047.1|- S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - - k59_306315_2 49964.O03965_9CAUD 5e-41 145.0 4QEW7@10239|Viruses,4QYXF@35237|dsDNA viruses no RNA stage,4QTWH@28883|Caudovirales,4QNW2@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_8910_1 742766.HMPREF9455_00233 8.17e-59 200.0 COG1783@1|root,COG1783@2|Bacteria,4PMA2@976|Bacteroidetes,2G2CX@200643|Bacteroidia 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_277855_1 1125779.HMPREF1219_00167 3.92e-24 106.0 COG3953@1|root,COG5412@1|root,COG3953@2|Bacteria,COG5412@2|Bacteria,2I5CG@201174|Actinobacteria,22KNY@1653|Corynebacteriaceae 201174|Actinobacteria M heme binding - - - - - - - - - - - - SLT k59_266244_1 357276.EL88_08430 7.63e-17 80.9 COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FQKQ@200643|Bacteroidia,4AQK8@815|Bacteroidaceae 976|Bacteroidetes K ParB-like nuclease domain - - - - - - - - - - - - DUF4417,ParBc k59_237692_1 1420600.W5RNT1_9CIRC 2.53e-23 99.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_132120_2 1238190.AMQY01000021_gene1601 8.11e-09 57.4 2EPGX@1|root,33H3H@2|Bacteria,1NMWX@1224|Proteobacteria,1SVYZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_308742_1 1000565.METUNv1_00538 2.68e-71 245.0 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,2VN8K@28216|Betaproteobacteria,2KXMM@206389|Rhodocyclales 206389|Rhodocyclales S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_253830_1 1307436.PBF_22113 1.53e-29 121.0 COG5280@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,4HGP4@91061|Bacilli,1ZBH7@1386|Bacillus 91061|Bacilli D minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_186190_1 318586.Pden_3368 1.89e-06 49.7 COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria,2UG4Y@28211|Alphaproteobacteria,2PYVW@265|Paracoccus 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 k59_386015_1 1795983.A0A140CTJ3_9CIRC 1.48e-12 70.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_416283_1 760117.JN27_00640 2.12e-17 88.2 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,2VRP1@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase k59_416283_2 932213.SPM24T3_09756 2.46e-08 52.8 2A44R@1|root,30SPT@2|Bacteria,1PC01@1224|Proteobacteria,1SWTC@1236|Gammaproteobacteria,4059Z@613|Serratia 1236|Gammaproteobacteria S Domain of unknown function (DUF4224) - - - - - - - - - - - - DUF4224 k59_106035_3 1123277.KB893195_gene5496 2.59e-12 70.1 COG0467@1|root,COG0467@2|Bacteria,4NIAQ@976|Bacteroidetes 976|Bacteroidetes T Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - AAA_25 k59_280163_3 145579.CAPSD_BPPHM 5.82e-103 326.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_173238_1 1437608.BBIA_1555 1.96e-10 64.7 COG3451@1|root,COG3451@2|Bacteria,2H6W2@201174|Actinobacteria,4CYWV@85004|Bifidobacteriales 201174|Actinobacteria U type IV secretory pathway VirB4 - - - - - - - - - - - - DUF87 k59_253834_2 391587.KAOT1_16558 1.99e-50 164.0 COG0791@1|root,COG0791@2|Bacteria,4NPFE@976|Bacteroidetes,1I29F@117743|Flavobacteriia 976|Bacteroidetes M CHAP domain - - - - - - - - - - - - CHAP k59_308749_1 489825.LYNGBM3L_47330 5.07e-31 134.0 COG2706@1|root,COG3507@1|root,COG5492@1|root,COG2706@2|Bacteria,COG3507@2|Bacteria,COG5492@2|Bacteria,1GQES@1117|Cyanobacteria 1117|Cyanobacteria G domain, Protein - - - - - - - - - - - - DUF1349 k59_25262_1 1219035.NT2_06_02220 9.49e-65 216.0 2CDQ7@1|root,2Z7KV@2|Bacteria,1MY2D@1224|Proteobacteria,2TR92@28211|Alphaproteobacteria,2K2I7@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_386023_3 1245471.PCA10_29080 1.26e-11 66.6 2CEG2@1|root,2ZCEX@2|Bacteria,1RB74@1224|Proteobacteria,1S2JC@1236|Gammaproteobacteria,1YHZE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Phage replication protein CRI - - - - - - - - - - - - Phage_CRI,Phage_X k59_308758_1 575540.Isop_2425 9.17e-43 158.0 COG5283@1|root,COG5283@2|Bacteria,2J1F5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_173258_1 398767.Glov_0777 1.57e-16 87.8 COG1216@1|root,COG1216@2|Bacteria,1R4ZP@1224|Proteobacteria,432JF@68525|delta/epsilon subdivisions,2WY2J@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_93705_2 1122994.AUFR01000004_gene703 8.34e-11 68.2 COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4DPD2@85009|Propionibacteriales 201174|Actinobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_386026_1 1029718.SFBM_0102 2.39e-26 114.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,36EZ3@31979|Clostridiaceae 186801|Clostridia L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_39147_1 1394176.AWUO01000014_gene644 5.18e-10 63.2 2BWS4@1|root,32XQ0@2|Bacteria,2GR3P@201174|Actinobacteria,4D1S1@85004|Bifidobacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_229040_2 691965.D4P7C3_9CAUD 5.8e-31 113.0 4QDCX@10239|Viruses,4R0GS@35237|dsDNA viruses no RNA stage,4QS3P@28883|Caudovirales,4QKU8@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_229040_3 1321814.HMPREF9089_00944 4.49e-12 68.9 COG0860@1|root,COG0860@2|Bacteria,1V7G8@1239|Firmicutes,25C1G@186801|Clostridia 186801|Clostridia M Ami_3 - - - - - - - - - - - - Amidase_3 k59_241561_1 345201.VF050_IIV3 9.02e-65 226.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage 10239|Viruses S N-acetyltransferase activity - - - - - - - - - - - - - k59_241561_2 1465751.W8QEY7_9VIRU 2.07e-36 130.0 4QHGT@10239|Viruses,4QZ3I@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_430953_1 1323663.AROI01000005_gene3116 7.72e-47 170.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein 1A mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_229092_1 1218086.BBNB01000014_gene2052 0.000984 47.0 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MU81@1224|Proteobacteria,1RS6P@1236|Gammaproteobacteria,3WXVW@544|Citrobacter 1236|Gammaproteobacteria D Lambda phage tail tape-measure protein (Tape_meas_lam_C) ynaA - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_229092_2 556269.ACDQ01000003_gene1353 2.15e-09 58.2 2EDKQ@1|root,337GJ@2|Bacteria,1NAT9@1224|Proteobacteria,2VXFY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_241611_3 627192.SLG_17490 8.69e-07 59.3 COG3378@1|root,COG5545@1|root,COG3378@2|Bacteria,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria L virulence-associated E family protein - - - - - - - - - - - - PriCT_2,Prim-Pol,VirE k59_229120_1 1788445.A0A190WHA3_9CIRC 5.76e-14 71.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_229120_2 1611039.A0A0C5C3Z3_9CIRC 7.74e-30 119.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_229128_1 1268240.ATFI01000007_gene431 1.61e-33 125.0 COG0863@1|root,COG0863@2|Bacteria,4NQQ1@976|Bacteroidetes,2G1PS@200643|Bacteroidia,4ARBB@815|Bacteroidaceae 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_430983_1 235985.BBPN01000033_gene51 8.79e-15 78.6 2CCFM@1|root,33T1W@2|Bacteria,2IA4M@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - PhyH k59_241694_1 1046714.AMRX01000006_gene3194 1.03e-21 99.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_364164_1 160860.XP_007358279.1 6e-05 50.8 COG0086@1|root,KOG0260@2759|Eukaryota,38CEW@33154|Opisthokonta,3NWQ7@4751|Fungi,3UYEK@5204|Basidiomycota,22815@155619|Agaricomycetes,3H3Q8@355688|Agaricomycetes incertae sedis 4751|Fungi K Beta and beta-prime subunits of DNA dependent RNA-polymerase RPO21 GO:0000228,GO:0000428,GO:0000731,GO:0000785,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005694,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006351,GO:0006366,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010494,GO:0016070,GO:0016591,GO:0018130,GO:0019438,GO:0019985,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:1990904 2.7.7.6 ko:K03006 ko00230,ko00240,ko01100,ko03020,ko05016,ko05168,ko05169,map00230,map00240,map01100,map03020,map05016,map05168,map05169 M00180 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb1_6,RNA_pol_Rpb1_7,RNA_pol_Rpb1_R k59_134880_2 716928.AJQT01000109_gene1217 2.21e-49 162.0 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_189721_1 1122201.AUAZ01000017_gene2960 1.12e-182 524.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_149341_3 879310.HMPREF9162_0069 6.29e-19 87.8 28NEI@1|root,2ZBH3@2|Bacteria,1U6F4@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_311577_1 1128421.JAGA01000002_gene367 3.24e-15 80.9 COG0658@1|root,COG0658@2|Bacteria 2|Bacteria S establishment of competence for transformation comE - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_108755_1 749413.E5DV63_9VIRU 2.26e-22 98.2 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage 10239|Viruses S HNH endonuclease - - - - - - - - - - - - - k59_162801_2 1419583.V466_28995 6.14e-08 57.4 COG5185@1|root,COG5281@1|root,COG5185@2|Bacteria,COG5281@2|Bacteria,1QUCD@1224|Proteobacteria,1T1T2@1236|Gammaproteobacteria,1YRAU@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria D Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Phage_HK97_TLTM,TMP_2,Tape_meas_lam_C k59_95342_1 1439940.BAY1663_02302 2.59e-25 103.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,1SCZN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - AP2,HNH_3 k59_203695_1 1795983.A0A140CTJ3_9CIRC 1.37e-08 56.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_28068_1 1123322.KB904711_gene5368 1.38e-05 48.9 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria 201174|Actinobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_122288_1 1056512.D515_00633 3.65e-40 149.0 COG0582@1|root,COG0582@2|Bacteria,1R43H@1224|Proteobacteria,1RNI0@1236|Gammaproteobacteria,1Y2DP@135623|Vibrionales 135623|Vibrionales L Arm DNA-binding domain VP0380 - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_135923_1 1120963.KB894501_gene316 1.07e-28 107.0 COG2852@1|root,COG2852@2|Bacteria,1N7EJ@1224|Proteobacteria,1SF5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF559 k59_162998_1 436308.Nmar_1073 0.000118 54.3 COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea 2157|Archaea C LamG domain protein jellyroll fold domain protein - - 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - Copper-bind,GSDH,Laminin_G_3,ThuA,fn3 k59_338560_2 1145276.T479_16370 4.76e-31 120.0 2C9JF@1|root,32RPD@2|Bacteria,1VC16@1239|Firmicutes,4HK64@91061|Bacilli 91061|Bacilli S ERF superfamily - - - - - - - - - - - - ERF k59_108954_2 742740.HMPREF9474_02280 3.35e-32 114.0 2CGGB@1|root,32UNH@2|Bacteria,1VD9W@1239|Firmicutes,24MWC@186801|Clostridia,2235P@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_163007_1 1122931.AUAE01000034_gene2778 2.94e-14 75.9 COG0467@1|root,COG0467@2|Bacteria,4P31Y@976|Bacteroidetes,2FSV1@200643|Bacteroidia 976|Bacteroidetes T AAA domain - - - - - - - - - - - - AAA_25 k59_41714_4 1327977.R9ZXS6_9CAUD 5.88e-20 89.7 4QE8A@10239|Viruses,4QXTV@35237|dsDNA viruses no RNA stage,4QS6D@28883|Caudovirales,4QNZR@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_137832_1 312153.Pnuc_1031 8.76e-26 104.0 2CMPB@1|root,32SF8@2|Bacteria,1NBR8@1224|Proteobacteria,2VXK5@28216|Betaproteobacteria 28216|Betaproteobacteria S SprT-like family - - - - - - - - - - - - SprT-like k59_83963_2 1094496.m07a_12040 1.6e-13 79.0 COG3170@1|root,COG3170@2|Bacteria,1R69E@1224|Proteobacteria,2U3B9@28211|Alphaproteobacteria,48TPA@772|Bartonellaceae 28211|Alphaproteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_271966_1 1316936.K678_00160 1.14e-15 77.0 2E16H@1|root,32WMB@2|Bacteria,1N6EU@1224|Proteobacteria,2UEWQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_83964_2 257310.BB2209 5.11e-42 150.0 COG0305@1|root,COG0305@2|Bacteria,1PP51@1224|Proteobacteria,2VQ9Z@28216|Betaproteobacteria,3T82N@506|Alcaligenaceae 28216|Betaproteobacteria L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C k59_151015_4 136993.KB900626_gene2777 7.05e-22 100.0 COG3179@1|root,COG3179@2|Bacteria,1RC1P@1224|Proteobacteria,2U5PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glycoside hydrolase, family 19 - - - ko:K03791 - - - - ko00000 - GH19 - Glyco_hydro_19,PG_binding_1,Trypsin k59_2615_2 1141662.OOA_07605 4.33e-06 53.5 COG4675@1|root,COG4675@2|Bacteria,1NW59@1224|Proteobacteria,1SPNA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein of Photorhabdus and some similarities with - - - - - - - - - - - - Collar k59_366853_2 95619.PM1_0217870 2.63e-34 124.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S6BA@1236|Gammaproteobacteria 1236|Gammaproteobacteria G lysozyme ybcS GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_353922_1 748449.Halha_0385 2.6e-17 90.1 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WA77@53433|Halanaerobiales 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_191301_1 1618248.A0A0C5IB82_9CIRC 2.6e-13 77.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_123799_1 1121028.ARQE01000018_gene2690 4.6e-21 103.0 COG1196@1|root,COG1511@1|root,COG1876@1|root,COG1196@2|Bacteria,COG1511@2|Bacteria,COG1876@2|Bacteria,1R2G1@1224|Proteobacteria,2TZJ9@28211|Alphaproteobacteria,2PMCK@255475|Aurantimonadaceae 28211|Alphaproteobacteria M Prophage tail length tape measure protein - - - - - - - - - - - - TMP_2 k59_327164_1 1140.Synpcc7942_0726 9.82e-18 80.1 2E3FM@1|root,32YEF@2|Bacteria 2|Bacteria S VRR-NUC domain - - - - - - - - - - - - VRR_NUC k59_2623_2 32049.SYNPCC7002_A0827 9.34e-17 84.7 COG0658@1|root,COG0658@2|Bacteria,1G11N@1117|Cyanobacteria,1GZJH@1129|Synechococcus 1117|Cyanobacteria S Competence protein comE - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131 k59_110418_1 1313172.YM304_00990 1.33e-29 118.0 COG5373@1|root,COG5373@2|Bacteria 2|Bacteria KLT membrane - - - - - - - - - - - - - k59_353926_1 411470.RUMGNA_00255 7.38e-08 55.8 COG1388@1|root,COG3757@1|root,COG1388@2|Bacteria,COG3757@2|Bacteria,1UDXP@1239|Firmicutes,25IS1@186801|Clostridia,3Y11S@572511|Blautia 186801|Clostridia M COG COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) - - - - - - - - - - - - CW_7 k59_353926_2 691965.D4P7C3_9CAUD 3.4e-42 142.0 4QDCX@10239|Viruses,4R0GS@35237|dsDNA viruses no RNA stage,4QS3P@28883|Caudovirales,4QKU8@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_191304_1 997884.HMPREF1068_00494 4.43e-22 99.4 COG0463@1|root,COG0463@2|Bacteria,4PN4G@976|Bacteroidetes,2G0PY@200643|Bacteroidia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_2627_2 1288484.APCS01000008_gene1249 9.16e-50 165.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_217831_1 525909.Afer_1638 4.23e-56 198.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_73347_1 397290.C810_01484 1.35e-34 130.0 2CWXD@1|root,32T0J@2|Bacteria,1VCVP@1239|Firmicutes,24MPK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_218760_1 568816.Acin_1997 4.08e-15 82.8 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H2EZ@909932|Negativicutes 909932|Negativicutes L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_395171_1 110365.A0A023AX31 3.36e-22 101.0 2EWQP@1|root,2SYH6@2759|Eukaryota 2759|Eukaryota S RNA helicase - - - - - - - - - - - - RNA_helicase,Viral_Rep k59_356148_1 1283077.M1I7K5_9CAUD 8.05e-17 82.0 4QBMX@10239|Viruses,4QV9I@35237|dsDNA viruses no RNA stage,4QQGF@28883|Caudovirales,4QNC1@10744|Podoviridae 10744|Podoviridae S Pfam:Tube - GO:0005575,GO:0019012 - - - - - - - - - - - k59_301128_1 871968.DESME_06845 1.9e-50 166.0 COG1738@1|root,COG1738@2|Bacteria,1V8R2@1239|Firmicutes,24K5V@186801|Clostridia,264VZ@186807|Peptococcaceae 186801|Clostridia S Putative vitamin uptake transporter - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_166101_1 691965.D4P7H8_9CAUD 2.14e-39 141.0 4QG1E@10239|Viruses,4QZE1@35237|dsDNA viruses no RNA stage,4QU6Q@28883|Caudovirales,4QMKH@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_166101_2 691965.D4P7I0_9CAUD 1.45e-78 247.0 4QDSZ@10239|Viruses,4QXJ8@35237|dsDNA viruses no RNA stage,4QPKE@28883|Caudovirales,4QM8R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_273745_1 1692252.A0A0K1RL35_9CIRC 2.27e-75 240.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_4379_1 1123311.KB904475_gene1422 1.42e-17 86.7 28KEB@1|root,2ZA0K@2|Bacteria,1V14E@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_316770_1 679201.HMPREF9334_00465 5.61e-12 65.5 2E3FM@1|root,32YEF@2|Bacteria 2|Bacteria S VRR-NUC domain - - - - - - - - - - - - VRR_NUC k59_316770_2 1121344.JHZO01000001_gene426 2.71e-08 63.2 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WGFW@541000|Ruminococcaceae 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_288806_1 1476391.X5KNA6_9CAUD 1.07e-67 214.0 4QEMD@10239|Viruses,4R0JN@35237|dsDNA viruses no RNA stage,4QUGF@28883|Caudovirales,4QNXF@10744|Podoviridae 10744|Podoviridae S AAA domain - - - - - - - - - - - - - k59_288806_2 655097.C8ZKG2_9CAUD 2.36e-34 134.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_249007_1 926549.KI421517_gene1288 1.02e-47 169.0 COG1783@1|root,COG1783@2|Bacteria,4PMA2@976|Bacteroidetes,47RRH@768503|Cytophagia 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_33774_2 760192.Halhy_3005 1.35e-38 133.0 COG0629@1|root,COG0629@2|Bacteria,4PGRJ@976|Bacteroidetes,1IU5E@117747|Sphingobacteriia 976|Bacteroidetes L Domain of unknown function (DUF3127) - - - - - - - - - - - - DUF3127 k59_46387_1 1527519.A0A076G7S4_9CAUD 9.28e-06 54.3 4QHK9@10239|Viruses,4QQVU@28883|Caudovirales,4QIVC@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_262929_1 207559.Dde_2342 5.96e-14 72.8 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2M8C4@213115|Desulfovibrionales 28221|Deltaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_262929_2 926561.KB900617_gene2185 1.74e-19 84.3 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia 186801|Clostridia G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_143380_1 268748.Q58N56_BPPRP 3.25e-19 83.2 4QD0J@10239|Viruses,4R0A5@35237|dsDNA viruses no RNA stage,4QSK9@28883|Caudovirales,4QNR4@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_219887_2 795359.TOPB45_1387 5.72e-10 61.6 COG0454@1|root,COG0456@2|Bacteria,2GHSZ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_423351_1 177439.DP0421 5.47e-155 478.0 COG0358@1|root,COG0358@2|Bacteria,1P00T@1224|Proteobacteria 1224|Proteobacteria L Toprim-like - - - - - - - - - - - - DUF927,Toprim_2 k59_143867_2 1030157.AFMP01000036_gene2710 2.1e-16 77.4 2E6JI@1|root,30UHX@2|Bacteria,1PP4A@1224|Proteobacteria,2V1MI@28211|Alphaproteobacteria,2KBR5@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_34070_2 1524467.IV04_24795 7.57e-21 92.4 COG0790@1|root,COG0790@2|Bacteria,1QWUU@1224|Proteobacteria,1T620@1236|Gammaproteobacteria 1236|Gammaproteobacteria S T5orf172 - - - - - - - - - - - - T5orf172 k59_168164_1 1122175.ATXU01000009_gene1785 2.87e-32 130.0 COG5412@1|root,COG5412@2|Bacteria,2IH91@201174|Actinobacteria,4FS9V@85023|Microbacteriaceae 201174|Actinobacteria S phage tail tape measure protein - - - - - - - - - - - - - k59_411542_1 1610834.A0A0C5PVF0_9CAUD 1.18e-06 55.8 4QBMV@10239|Viruses,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_370335_1 1095747.HMPREF1049_0987 2.32e-14 73.2 COG0847@1|root,COG0847@2|Bacteria,37AH9@32066|Fusobacteria 32066|Fusobacteria L Exonuclease - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_370335_2 525254.HMPREF0072_1314 1.22e-19 87.8 COG1694@1|root,COG1694@2|Bacteria 2|Bacteria FG Mazg nucleotide pyrophosphohydrolase mazG - - - - - - - - - - - MazG k59_222054_2 1120936.KB907208_gene1108 2.21e-40 147.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4EGN4@85012|Streptosporangiales 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - - - - - - - - - - RecA k59_384521_1 648251.Q9JFY0_BMDNS 1.17e-09 68.6 4QAUG@10239|Viruses,4QUM5@29258|ssDNA viruses 10239|Viruses L Parvovirus non-structural protein NS1 - GO:0001906,GO:0001907,GO:0005575,GO:0008150,GO:0009889,GO:0010556,GO:0010941,GO:0010942,GO:0016032,GO:0018995,GO:0019048,GO:0019051,GO:0019054,GO:0019056,GO:0019058,GO:0019079,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031341,GO:0031343,GO:0031640,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0035821,GO:0039526,GO:0039592,GO:0039656,GO:0039685,GO:0039693,GO:0042025,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044071,GO:0044215,GO:0044216,GO:0044217,GO:0044364,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0044533,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051726,GO:0051817,GO:0051818,GO:0051883,GO:0052026,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052312,GO:0052330,GO:0052433,GO:0052501,GO:0060139,GO:0060153,GO:0060255,GO:0065007,GO:0080090,GO:2001141 - - - - - - - - - - - k59_49449_1 367299.JOEE01000008_gene438 7.46e-48 169.0 COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4FEVM@85021|Intrasporangiaceae 201174|Actinobacteria M UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase,HTH_3 k59_80295_1 1317118.ATO8_18645 0.000267 49.3 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,4KNR9@93682|Roseivivax 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_183940_1 76114.ebA5486 1.98e-12 73.9 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2WGSR@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_36711_1 1115515.EV102420_11_00200 4.1e-42 156.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria,3XQ6B@561|Escherichia 1236|Gammaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_292076_1 76636.JOEC01000008_gene1481 1.02e-07 50.8 COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria,4FS7A@85023|Microbacteriaceae 201174|Actinobacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_306198_1 1327981.S0A1R5_9CAUD 1.82e-25 108.0 4QGUS@10239|Viruses,4QX38@35237|dsDNA viruses no RNA stage,4QRVV@28883|Caudovirales,4QN8J@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_63080_2 1219031.BBJR01000049_gene1548 2.55e-30 120.0 COG3756@1|root,COG3756@2|Bacteria,1QUEM@1224|Proteobacteria,2WHQP@28216|Betaproteobacteria,4AIKF@80864|Comamonadaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_116419_4 266809.PM03_15090 1.68e-52 178.0 COG3409@1|root,COG4322@1|root,COG3409@2|Bacteria,COG4322@2|Bacteria,1NCJ6@1224|Proteobacteria,2U1UB@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_197557_2 557598.LHK_01799 2.1e-86 270.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,2KR09@206351|Neisseriales 206351|Neisseriales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_93622_2 1986029.Q9MBM8_9VIRU 5.66e-58 201.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_118318_2 1121124.JNIX01000011_gene1682 2.69e-34 140.0 COG2188@1|root,COG2188@2|Bacteria,1R5UI@1224|Proteobacteria,2U1BC@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_93623_1 867903.ThesuDRAFT_00642 1.95e-39 154.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WCDF@538999|Clostridiales incertae sedis 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_132700_1 1157943.KB892705_gene2039 4.96e-99 302.0 COG3969@1|root,COG3969@2|Bacteria,2H4MT@201174|Actinobacteria 201174|Actinobacteria S Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_268844_2 1401065.HMPREF2130_10705 1.28e-17 90.1 2E8SI@1|root,3333B@2|Bacteria,1N7MG@1224|Proteobacteria,2W67P@28216|Betaproteobacteria,3T896@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_93889_2 930945.SiRe_0088 4.35e-09 61.2 COG1051@1|root,arCOG01075@2157|Archaea,2XR8E@28889|Crenarchaeota 28889|Crenarchaeota L PFAM NUDIX hydrolase - - 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000,ko03400 - - - NUDIX k59_118513_1 102129.Lepto7375DRAFT_0555 4.76e-50 182.0 COG1061@1|root,COG1061@2|Bacteria 2|Bacteria L Type III restriction enzyme res subunit - - - - - - - - - - - - HA,Helicase_C,Mrr_cat_2,ResIII k59_254055_1 349161.Dred_3044 6.02e-09 63.2 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_308993_1 580332.Slit_1922 5.05e-27 116.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2VM59@28216|Betaproteobacteria 28216|Betaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_224340_1 1692246.A0A0K1RL26_9CIRC 1.36e-34 129.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_133192_2 1449126.JQKL01000003_gene1695 1.97e-29 120.0 28W6R@1|root,2ZI7D@2|Bacteria,1V1MZ@1239|Firmicutes,24FAN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_11322_1 29306.JOBE01000087_gene3938 3.84e-18 92.8 COG3378@1|root,COG5519@1|root,COG3378@2|Bacteria,COG5519@2|Bacteria,2H1DT@201174|Actinobacteria 201174|Actinobacteria T Phage plasmid primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,Toprim_2 k59_388_132 1357714.A0A067XQT2_9CAUD 1.18e-23 99.4 4QCUC@10239|Viruses,4QY13@35237|dsDNA viruses no RNA stage,4QQ7E@28883|Caudovirales,4QIRS@10662|Myoviridae 10662|Myoviridae S endodeoxyribonuclease activity - - - - - - - - - - - - - k59_388_133 948071.S4S2D9_9CAUD 2.29e-78 254.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_311125_1 1379709.S5TMV0_9CIRC 4.9e-78 244.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_364886_1 1385658.U5KPZ6_9VIRU 3.18e-47 168.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_351415_1 1500890.JQNL01000001_gene3314 6.78e-14 77.0 COG0845@1|root,COG4733@1|root,COG0845@2|Bacteria,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,1XABA@135614|Xanthomonadales 135614|Xanthomonadales M Phage-related protein, tail component - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_405438_1 49964.Q94MS1_9CAUD 4.29e-23 95.9 4QB4H@10239|Viruses,4QYQI@35237|dsDNA viruses no RNA stage,4QUAR@28883|Caudovirales,4QNUV@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_27713_1 292459.STH4 1.78e-24 105.0 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia 186801|Clostridia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_81620_1 322710.Avin_51170 9e-07 56.6 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins psmE - - - - - - - - - - - Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C k59_149193_3 1692252.A0A0K1RL35_9CIRC 2.14e-92 283.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_41363_1 1121116.KB894768_gene1947 5.78e-23 93.2 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria 28216|Betaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_311398_1 1265490.JHVY01000003_gene3123 6.79e-07 61.2 COG4733@1|root,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,1S1E5@1236|Gammaproteobacteria 1236|Gammaproteobacteria D COG4733 Phage-related protein, tail component - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF1983,Phage-tail_3 k59_365051_1 253839.SSNG_02571 1.32e-12 77.0 2E9RT@1|root,32Y7C@2|Bacteria,2I89H@201174|Actinobacteria 201174|Actinobacteria S Siphovirus ReqiPepy6 Gp37-like protein - - - - - - - - - - - - Sipho_Gp37 k59_667_1 1548905.A0A0A1IUL8_9CAUD 6.57e-57 192.0 4QBA2@10239|Viruses,4QPPI@28883|Caudovirales,4QM0B@10699|Siphoviridae 10699|Siphoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_29315_2 311424.DhcVS_1286 6.35e-24 102.0 2DBHG@1|root,2Z99H@2|Bacteria 2|Bacteria - - mom - - ko:K21527 - - - - ko00000,ko01000 - - - - k59_190891_1 74545.EU96_1318 4.27e-12 71.6 COG3740@1|root,COG4653@1|root,COG3740@2|Bacteria,COG4653@2|Bacteria,1GMY2@1117|Cyanobacteria,1MNEB@1212|Prochloraceae 1117|Cyanobacteria OU Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_29322_1 1105367.CG50_14080 2.47e-16 75.5 COG4902@1|root,COG4902@2|Bacteria,1QW29@1224|Proteobacteria,2TYIW@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - DUF2202 k59_271721_2 294631.Q5ZGG1_9CAUD 1.12e-70 233.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_407066_1 411470.RUMGNA_02077 1.47e-06 54.3 COG4722@1|root,COG4722@2|Bacteria,1V3B1@1239|Firmicutes,24G0I@186801|Clostridia,3Y0PN@572511|Blautia 186801|Clostridia S COG NOG18823 non supervised orthologous group - - - - - - - - - - - - Sipho_tail k59_96748_5 935848.JAEN01000011_gene1889 1.65e-07 50.1 2AETX@1|root,314R5@2|Bacteria,1PUJZ@1224|Proteobacteria,2V4X4@28211|Alphaproteobacteria,2PXZN@265|Paracoccus 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_393251_2 211165.AJLN01000058_gene2798 9.27e-18 82.0 COG4474@1|root,COG4474@2|Bacteria,1G93K@1117|Cyanobacteria,1JMM2@1189|Stigonemataceae 1117|Cyanobacteria K Protein of unknown function (DUF1273) - - - - - - - - - - - - DUF1273 k59_285392_2 767434.Fraau_1253 8.96e-34 121.0 COG2131@1|root,COG2131@2|Bacteria,1NC75@1224|Proteobacteria,1T01U@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Deoxycytidylate deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_205065_1 316274.Haur_1369 0.000138 54.3 COG4372@1|root,COG5283@1|root,COG5412@1|root,COG4372@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,2G9J0@200795|Chloroflexi 2|Bacteria M TIGRFAM phage tail tape measure protein, TP901 family Z012_10445 - - ko:K01991,ko:K07161,ko:K07484 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - DDE_Tnp_IS66,DUF3084,LZ_Tnp_IS66,PhageMin_Tail,zf-IS66 k59_407074_1 1449976.KALB_4957 1.64e-12 68.6 COG1403@1|root,COG1403@2|Bacteria,2GXG1@201174|Actinobacteria 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - HNH k59_179394_1 747.DR93_1216 4.55e-16 73.9 2AMM7@1|root,31CH8@2|Bacteria,1RJ8Y@1224|Proteobacteria,1SAP1@1236|Gammaproteobacteria,1Y8V6@135625|Pasteurellales 135625|Pasteurellales L Pyrimidine dimer DNA glycosylase denV - 3.1.25.1 ko:K01161 - - - - ko00000,ko01000 - - - Pyr_excise k59_232425_1 742767.HMPREF9456_03404 1.6e-40 141.0 COG0270@1|root,COG0270@2|Bacteria,4P351@976|Bacteroidetes 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_192614_1 742733.HMPREF9469_05020 2.4e-184 600.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_192614_2 1537917.JU82_09980 5.31e-32 116.0 2ARVA@1|root,31H70@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HK97-gp10_like k59_192614_3 1123302.KB904167_gene530 2.53e-05 54.7 COG4675@1|root,COG4675@2|Bacteria,1V63H@1239|Firmicutes,4HMFP@91061|Bacilli 91061|Bacilli S the current gene model (or a revised gene model) may contain a frame shift - - - - - - - - - - - - DUF859 k59_17531_1 1379722.S5SY31_9CIRC 1.48e-69 221.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_98722_2 1401065.HMPREF2130_11670 7.92e-18 79.7 2E6H8@1|root,3314G@2|Bacteria,1NFU2@1224|Proteobacteria,2VX6F@28216|Betaproteobacteria,3T7MY@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_72950_4 1463841.JOIR01000011_gene2648 3.7e-21 102.0 2DR0B@1|root,339N1@2|Bacteria,2IS7F@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_300896_1 420324.KI912051_gene6027 1.14e-36 142.0 COG0827@1|root,COG1475@1|root,COG4646@1|root,COG0827@2|Bacteria,COG1475@2|Bacteria,COG4646@2|Bacteria,1QVTP@1224|Proteobacteria,2TWUB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA restriction-modification system - - - - - - - - - - - - N6_Mtase k59_300899_1 665956.HMPREF1032_00674 1.27e-21 95.9 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,3WNJZ@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_328681_1 329381.D9ICQ3_9CAUD 4.13e-11 68.6 4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses no RNA stage,4QPCE@28883|Caudovirales,4QI56@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_408979_2 411901.BACCAC_01204 1.42e-20 93.6 2AFCI@1|root,315C5@2|Bacteria,4PJJ2@976|Bacteroidetes,2FS4G@200643|Bacteroidia,4AQI0@815|Bacteroidaceae 976|Bacteroidetes S KilA-N domain - - - - - - - - - - - - KilA-N k59_31510_1 105154.Q9MBU3_9VIRU 1.88e-09 58.9 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_31510_2 1385658.U5KPZ6_9VIRU 5.05e-115 346.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_72966_1 1121918.ARWE01000001_gene1797 6.45e-05 54.7 COG1404@1|root,COG1404@2|Bacteria,1QYWU@1224|Proteobacteria,42VXP@68525|delta/epsilon subdivisions,2X7PK@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_5892_1 1234888.K0A2J2_9VIRU 1.94e-97 302.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_101088_1 1027273.GZ77_09600 8.43e-19 79.0 2EC8I@1|root,33670@2|Bacteria,1NH09@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_101088_2 240292.Ava_D0020 1.07e-26 107.0 2CPKU@1|root,32SJD@2|Bacteria,1G8WS@1117|Cyanobacteria,1HSH3@1161|Nostocales 1117|Cyanobacteria L 3' exoribonuclease, RNase T-like - - - - - - - - - - - - DUF5051 k59_46486_3 864069.MicloDRAFT_00064680 0.000274 44.7 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,1JWXQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria S terminase, large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_318675_2 345201.RPB1_IIV3 4.95e-93 303.0 4QARB@10239|Viruses,4QV3H@35237|dsDNA viruses no RNA stage 10239|Viruses S RNA polymerase Rpb1, domain 3 - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_194609_1 547045.NEISICOT_01398 6.12e-40 151.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2VKKT@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_194609_2 1125863.JAFN01000001_gene3547 3.73e-35 129.0 2E13U@1|root,32WJ6@2|Bacteria,1NFFY@1224|Proteobacteria,42Y14@68525|delta/epsilon subdivisions,2WTCY@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_194609_3 754476.Q7A_352 2.77e-07 49.7 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_234179_3 999541.bgla_1g10975 2.49e-55 201.0 2DXBN@1|root,344AA@2|Bacteria,1P1KE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_318690_1 1618238.A0A0C5I2G8_9CIRC 6.65e-49 167.0 4QASI@10239|Viruses,4QUM7@29258|ssDNA viruses 10239|Viruses L Geminivirus coat protein/nuclear export factor BR1 family - GO:0005575,GO:0018995,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0042025,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_5909_1 546262.NEICINOT_05073 1.65e-98 302.0 COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria 2|Bacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,ParBc k59_210222_3 1005999.GLGR_1993 2.5e-31 116.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S99W@1236|Gammaproteobacteria 1236|Gammaproteobacteria G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_143526_1 1096546.WYO_0193 1.32e-112 337.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria 1224|Proteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_20055_2 330214.NIDE4180 7.21e-35 127.0 COG2353@1|root,COG2353@2|Bacteria 2|Bacteria O YceI-like domain Cj0420 - - - - - - - - - - - YceI k59_88423_1 1609634.A0A0C5AFV4_9VIRU 5.3e-61 204.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_396989_1 1618240.A0A0C5IMJ1_9CIRC 9.28e-75 234.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_358930_1 1121365.AQXB01000009_gene565 4.15e-38 145.0 COG5412@1|root,COG5412@2|Bacteria,2IH91@201174|Actinobacteria 201174|Actinobacteria E phage tail tape measure protein - - - - - - - - - - - - - k59_113809_1 1618248.A0A0C5IB82_9CIRC 4.96e-85 264.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_62439_1 585506.HMPREF0877_0130 3.85e-11 63.2 COG3617@1|root,COG3645@1|root,COG3617@2|Bacteria,COG3645@2|Bacteria,1TPKA@1239|Firmicutes,4HDVT@91061|Bacilli,4AY8F@81850|Leuconostocaceae 91061|Bacilli K BRO family, N-terminal domain - - - ko:K07741 - - - - ko00000 - - - ANT,Bro-N,ORF6C k59_331805_2 498761.HM1_0138 4.27e-21 97.4 COG4733@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5492@2|Bacteria,1UHXK@1239|Firmicutes,25E6U@186801|Clostridia 186801|Clostridia N S-layer homology domain - - - - - - - - - - - - Big_2,CBM_X2,Flg_new,I-set,Laminin_G_3,SLH k59_361508_1 398527.Bphyt_7323 7.92e-08 57.0 COG1961@1|root,COG1961@2|Bacteria,1QTU0@1224|Proteobacteria,2VITE@28216|Betaproteobacteria,1K1XD@119060|Burkholderiaceae 28216|Betaproteobacteria L Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_36159_1 585.DR95_340 6.98e-22 94.7 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558,ko:K17398 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_384329_1 1265505.ATUG01000003_gene149 1.69e-42 158.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_305818_1 398578.Daci_4158 8.55e-20 90.1 COG1961@1|root,COG1961@2|Bacteria,1QTU0@1224|Proteobacteria,2VITE@28216|Betaproteobacteria,4AD9E@80864|Comamonadaceae 28216|Betaproteobacteria L Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_251357_3 1538804.A0A088F6T3_9CAUD 4.71e-128 392.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_425665_3 696281.Desru_1083 1.96e-12 65.1 2E38J@1|root,32Y88@2|Bacteria,1VAXK@1239|Firmicutes,24N7K@186801|Clostridia 186801|Clostridia S VRR-NUC domain protein - - - - - - - - - - - - VRR_NUC k59_425665_4 742743.HMPREF9453_00576 6.5e-41 150.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H2W4@909932|Negativicutes 909932|Negativicutes L SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_236230_2 634499.EpC_20810 5.82e-09 60.1 COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,1S2SY@1236|Gammaproteobacteria,3X7QN@551|Erwinia 1236|Gammaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. yfdR GO:0002953,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 - ko:K06952 - - - - ko00000 - - - - k59_8492_1 697281.Mahau_1396 9.57e-36 129.0 COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,42G8B@68295|Thermoanaerobacterales 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_197004_1 428125.CLOLEP_01411 8.16e-14 75.5 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,3WNJZ@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_103466_2 10228.TriadP52877 4.75e-17 85.9 2D04N@1|root,2SCSW@2759|Eukaryota,3AE35@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - - k59_197006_1 411473.RUMCAL_00273 1.18e-08 56.2 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,24CGS@186801|Clostridia 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_197006_2 908340.HMPREF9406_2595 2.82e-27 112.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,24DVA@186801|Clostridia,36FNM@31979|Clostridiaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_223399_1 363253.LI0159 9.01e-56 187.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2M8QY@213115|Desulfovibrionales 28221|Deltaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_237487_1 511051.CSE_14730 1.3e-75 237.0 COG2805@1|root,COG2805@2|Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT - - ko:K02652,ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_215757_1 755731.Clo1100_3514 3.92e-07 59.3 28HR1@1|root,2Z7YI@2|Bacteria,1TRNR@1239|Firmicutes,2486X@186801|Clostridia,36DIM@31979|Clostridiaceae 186801|Clostridia S amidoligase enzyme - - - - - - - - - - - - Amidoligase_2 k59_267703_1 1692242.A0A0K1RL37_9CIRC 1.12e-06 56.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_199309_2 394503.Ccel_0827 2.02e-19 97.4 292XD@1|root,2ZQEV@2|Bacteria,1V0SE@1239|Firmicutes,25F9W@186801|Clostridia,36WFA@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_427426_1 72664.XP_006415605.1 1.77e-05 53.1 COG1403@1|root,2QQI3@2759|Eukaryota,37PXC@33090|Viridiplantae,3GEP1@35493|Streptophyta,3HMVS@3699|Brassicales 35493|Streptophyta V HNH endonuclease - - - - - - - - - - - - HNH_5 k59_373854_6 568816.Acin_1400 3.95e-15 85.9 COG1196@1|root,COG1196@2|Bacteria,1TSKM@1239|Firmicutes,4H7DW@909932|Negativicutes 909932|Negativicutes D AAA ATPase domain - - - - - - - - - - - - AAA_23 k59_373854_7 701347.Entcl_1853 3.6e-15 75.9 COG4570@1|root,COG4570@2|Bacteria,1RH5J@1224|Proteobacteria,1S7I6@1236|Gammaproteobacteria,3X402@547|Enterobacter 1236|Gammaproteobacteria L PFAM endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_294678_1 758.BBIX01000009_gene1638 5.18e-46 162.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1Y75U@135625|Pasteurellales 135625|Pasteurellales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_427627_1 1051675.G0YQG4_9CAUD 7.94e-66 223.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_308067_1 742738.HMPREF9460_04053 2.21e-39 144.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,24B1A@186801|Clostridia,26A94@186813|unclassified Clostridiales 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_131932_1 940282.CADQ01000042_gene690 5.31e-56 193.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,2JYGZ@204441|Rhodospirillales 204441|Rhodospirillales S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_10501_2 1036616.G1DUU3_9CAUD 1.32e-19 82.8 4QCCA@10239|Viruses,4QY28@35237|dsDNA viruses no RNA stage,4QU0Q@28883|Caudovirales,4QNA0@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_10501_3 1218352.B597_019455 1.74e-23 95.5 2EIQ2@1|root,33CFI@2|Bacteria,1NHAI@1224|Proteobacteria,1SSQC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_51360_1 1206731.BAGB01000170_gene4596 9.18e-06 53.1 COG4974@1|root,COG4974@2|Bacteria,2IGA2@201174|Actinobacteria 201174|Actinobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_282133_1 428125.CLOLEP_01409 4.22e-112 338.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_239074_1 1095737.HMPREF1110_1747 1.47e-13 75.1 COG0466@1|root,COG3420@1|root,COG4733@1|root,COG0466@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 5.1.3.37 ko:K01795,ko:K07452,ko:K20276 ko00051,ko02024,map00051,map02024 - R08693 RC00509 ko00000,ko00001,ko01000,ko02048 - - - Beta_helix,Big_2,DUF1735,DUF349,Laminin_G_3,Prophage_tail,SLH k59_375738_5 948071.S4S2L2_9CAUD 5.07e-08 65.5 4QHQ5@10239|Viruses,4QR7K@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_107519_1 1500890.JQNL01000001_gene3314 1.86e-09 64.7 COG0845@1|root,COG4733@1|root,COG0845@2|Bacteria,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,1XABA@135614|Xanthomonadales 135614|Xanthomonadales M Phage-related protein, tail component - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_187800_1 285514.JNWO01000071_gene4 3.38e-19 88.6 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_429686_1 529709.PYCH_15560 6.63e-07 56.6 COG0417@1|root,COG1372@1|root,arCOG00328@2157|Archaea,arCOG03145@2157|Archaea,2XU1K@28890|Euryarchaeota,242Z2@183968|Thermococci 183968|Thermococci L DNA polymerase pol - 2.7.7.7 ko:K02319 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032 - - - DNA_pol_B,DNA_pol_B_exo1,Intein_splicing,LAGLIDADG_3 k59_225763_1 245174.XP_009269045.1 7.65e-20 86.3 COG0361@1|root,KOG3403@2759|Eukaryota,3A1R5@33154|Opisthokonta,3P2UG@4751|Fungi,3V0VS@5204|Basidiomycota 4751|Fungi J Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits TIF11 GO:0001731,GO:0001732,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003727,GO:0003743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010494,GO:0016043,GO:0016282,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0031369,GO:0032991,GO:0033290,GO:0033592,GO:0034622,GO:0034641,GO:0034645,GO:0035770,GO:0036464,GO:0043021,GO:0043024,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070993,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0097617,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K03236 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - eIF-1a k59_282749_1 81824.XP_001746860.1 9.71e-33 129.0 COG1372@1|root,2QRRC@2759|Eukaryota,39SG8@33154|Opisthokonta 33154|Opisthokonta L reductase - - - - - - - - - - - - Ribonuc_red_lgC k59_188549_1 1121935.AQXX01000130_gene2403 3.01e-05 52.4 COG4733@1|root,COG4733@2|Bacteria,1R77Q@1224|Proteobacteria,1S1WT@1236|Gammaproteobacteria,1XMZT@135619|Oceanospirillales 135619|Oceanospirillales D Fibronectin type 3 domain - - - - - - - - - - - - - k59_430369_1 999413.HMPREF1094_04525 1.26e-09 59.7 COG4942@1|root,COG4942@2|Bacteria 2|Bacteria D peptidase p40 - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - CHAP,Hydrolase_2,NLPC_P60,Peptidase_M23 k59_430369_2 753085.F4YCR7_9CAUD 8.2e-23 100.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_376583_1 457424.BFAG_01448 8.48e-36 133.0 COG3740@1|root,COG3740@2|Bacteria,4NDXV@976|Bacteroidetes,2FQ9I@200643|Bacteroidia,4APPV@815|Bacteroidaceae 976|Bacteroidetes S Phage prohead protease, HK97 family - - - - - - - - - - - - - k59_120672_1 1348657.M622_03060 1.25e-34 133.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VHAI@28216|Betaproteobacteria,2KV9D@206389|Rhodocyclales 206389|Rhodocyclales L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,ResIII k59_188569_1 1796001.A0A140CTP1_9CIRC 1.09e-29 114.0 4QAZA@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_188569_2 1796001.A0A140CTP3_9CIRC 2.97e-121 349.0 4QB6C@10239|Viruses 10239|Viruses L Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_387676_1 1122201.AUAZ01000017_gene2960 1.83e-106 322.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_430398_1 97139.C824_00123 1.84e-90 276.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_282788_1 1158292.JPOE01000005_gene1222 4.85e-28 109.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,1KKNH@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_188584_1 1618248.A0A0C5IB82_9CIRC 4.19e-68 221.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_403646_2 1132442.KB889752_gene2837 4.29e-05 50.1 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - 3.1.1.32,3.1.1.4 ko:K01058,ko:K07502 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - DUF2911,PEGA,T5orf172 k59_226558_1 1504822.CCNO01000015_gene594 8.71e-65 218.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_388_83 935848.JAEN01000004_gene1320 1.04e-23 97.4 COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,2PX25@265|Paracoccus 28211|Alphaproteobacteria O Belongs to the small heat shock protein (HSP20) family ibpA - - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_388_84 717773.Thicy_0938 1.17e-06 54.7 28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,1S23F@1236|Gammaproteobacteria,460Z8@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_391973_1 437329.A5A3Q5_9CAUD 6.95e-28 128.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_216500_4 1266925.JHVX01000002_gene717 2.27e-36 153.0 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,2VRS0@28216|Betaproteobacteria,372PP@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_203590_1 323259.Mhun_2566 9.75e-09 55.1 arCOG03403@1|root,arCOG03403@2157|Archaea,2Y5T8@28890|Euryarchaeota 28890|Euryarchaeota K PemK-like, MazF-like toxin of type II toxin-antitoxin system - - - ko:K07171 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin k59_14129_1 105154.Q9MBU6_9VIRU 1.47e-165 486.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_14129_3 1165094.RINTHH_3920 7.56e-66 216.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_14129_6 1986029.Q9MBM8_9VIRU 3.51e-20 89.4 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_365037_2 1618258.A0A0C5I9K3_9CIRC 1.3e-39 145.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_149158_1 366394.Smed_1896 1.08e-63 211.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,4BB3U@82115|Rhizobiaceae 28211|Alphaproteobacteria S Large terminase - - - - - - - - - - - - Terminase_3,Terminase_6,Terminase_6C k59_297404_3 269484.Ecaj_0571 1.55e-94 301.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,47F12@766|Rickettsiales 766|Rickettsiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_297404_8 765698.Mesci_4761 1.86e-54 196.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,43I71@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_297404_12 658172.CKC_05790 2.99e-16 89.7 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,2U1ZX@28211|Alphaproteobacteria,4BAYZ@82115|Rhizobiaceae 28211|Alphaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - Terminase_6 k59_297404_14 879308.HMPREF9130_0415 2.85e-08 54.7 2E3AH@1|root,32YA0@2|Bacteria,1VEBX@1239|Firmicutes,24U5S@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1064) - - - - - - - - - - - - DUF1064 k59_162595_1 198110.B3FK10_9CAUD 2.54e-40 147.0 4QBHW@10239|Viruses,4QVHG@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QJZQ@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_338062_1 1121946.AUAX01000038_gene2638 1.93e-10 67.4 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DA63@85008|Micromonosporales 201174|Actinobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_70487_1 76636.JOEC01000001_gene1138 4.27e-41 155.0 2AYQQ@1|root,31QVM@2|Bacteria,2HT0W@201174|Actinobacteria,4FR6P@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_326527_5 1123288.SOV_2c10440 1.71e-105 328.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4H2V4@909932|Negativicutes 909932|Negativicutes KL DEAD-like helicases superfamily - - - - - - - - - - - - N6_N4_Mtase k59_326527_6 1089548.KI783301_gene2629 1.82e-86 271.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_326527_7 1121413.JMKT01000009_gene1836 6.12e-16 73.2 2DSBQ@1|root,33FEE@2|Bacteria,1NQ03@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_326527_8 940282.CADQ01000022_gene2093 2.04e-54 186.0 2CHRY@1|root,30Z9E@2|Bacteria,1RGQK@1224|Proteobacteria,2U9J0@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - RecT k59_326527_10 857293.CAAU_0783 1.12e-31 124.0 2DPDW@1|root,331PC@2|Bacteria,1VX8E@1239|Firmicutes 1239|Firmicutes S Domain of unknown function (DUF4373) - - - - - - - - - - - - DUF4373 k59_42737_3 1408428.JNJP01000079_gene3376 4.78e-10 61.2 COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2WNPI@28221|Deltaproteobacteria,2MCRU@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM nuclease (SNase domain protein) - - - - - - - - - - - - Excalibur,SNase k59_340091_1 345201.VF184_IIV3 1.12e-129 399.0 4QAY9@10239|Viruses,4QV7W@35237|dsDNA viruses no RNA stage 10239|Viruses S D5 N terminal like - GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_177394_1 1255043.TVNIR_2107 1.1e-117 350.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1WX3N@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_190988_1 1283284.AZUK01000001_gene2661 1.05e-09 66.2 2FDEM@1|root,345G9@2|Bacteria,1P332@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_204980_1 460265.Mnod_4282 1.28e-62 211.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,1JX89@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM peptidase U35 phage prohead HK97 - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_123398_2 323261.Noc_0053 6.81e-102 317.0 COG0305@1|root,COG0305@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria,1X1UJ@135613|Chromatiales 135613|Chromatiales L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - DnaB_C k59_150797_2 1392540.P256_02368 2.84e-06 58.2 COG1215@1|root,COG1215@2|Bacteria,1R1CS@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - - k59_326895_1 1317122.ATO12_02610 1.05e-24 102.0 COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes,1HYG0@117743|Flavobacteriia 976|Bacteroidetes S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_409127_1 11082.PRO_0000037750 3.42e-160 467.0 4QBXT@10239|Viruses,4R138@439488|ssRNA viruses,4R0R1@35278|ssRNA positive-strand viruses no DNA stage 10239|Viruses K ATP-dependent helicase activity - GO:0001510,GO:0001959,GO:0001960,GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0003824,GO:0004482,GO:0004483,GO:0005488,GO:0005575,GO:0006139,GO:0006370,GO:0006396,GO:0006397,GO:0006508,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008171,GO:0008173,GO:0008174,GO:0008233,GO:0008757,GO:0009451,GO:0009452,GO:0009605,GO:0009607,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010648,GO:0010941,GO:0016032,GO:0016070,GO:0016071,GO:0016192,GO:0016556,GO:0016740,GO:0016741,GO:0016787,GO:0018995,GO:0019012,GO:0019031,GO:0019048,GO:0019049,GO:0019050,GO:0019054,GO:0019058,GO:0019065,GO:0019068,GO:0019219,GO:0019222,GO:0019538,GO:0020012,GO:0023051,GO:0023057,GO:0030260,GO:0030430,GO:0030682,GO:0030683,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031347,GO:0031348,GO:0032259,GO:0032991,GO:0032993,GO:0033592,GO:0033643,GO:0033646,GO:0033655,GO:0033668,GO:0034641,GO:0035821,GO:0036260,GO:0036265,GO:0036338,GO:0039502,GO:0039503,GO:0039526,GO:0039713,GO:0039714,GO:0042981,GO:0043067,GO:0043069,GO:0043170,GO:0043207,GO:0043412,GO:0043414,GO:0043487,GO:0043489,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044068,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044409,GO:0044413,GO:0044414,GO:0044415,GO:0044419,GO:0044423,GO:0044501,GO:0044531,GO:0044532,GO:0044766,GO:0045069,GO:0045070,GO:0045088,GO:0045824,GO:0045934,GO:0046483,GO:0046718,GO:0046755,GO:0046762,GO:0046794,GO:0048518,GO:0048519,GO:0048523,GO:0048524,GO:0048583,GO:0048585,GO:0050690,GO:0050776,GO:0050777,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051806,GO:0051807,GO:0051817,GO:0051828,GO:0051832,GO:0051833,GO:0051834,GO:0052027,GO:0052029,GO:0052031,GO:0052037,GO:0052040,GO:0052041,GO:0052150,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052248,GO:0052250,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052433,GO:0052490,GO:0052493,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060147,GO:0060149,GO:0060255,GO:0060338,GO:0060339,GO:0060548,GO:0060759,GO:0060761,GO:0060966,GO:0060967,GO:0060968,GO:0060969,GO:0065007,GO:0065008,GO:0071704,GO:0072583,GO:0075109,GO:0075111,GO:0075112,GO:0075114,GO:0075136,GO:0075509,GO:0075512,GO:0075528,GO:0080009,GO:0080090,GO:0080134,GO:0090304,GO:0097159,GO:0097617,GO:0098657,GO:0106005,GO:0140096,GO:0140098,GO:1900368,GO:1900369,GO:1901360,GO:1901363,GO:1901564,GO:1902369,GO:1902579,GO:1903900,GO:1903902,GO:1990814,GO:1990904 - - - - - - - - - - - k59_58581_3 948071.S4S2S9_9CAUD 2.36e-50 183.0 4QBYN@10239|Viruses,4QZT8@35237|dsDNA viruses no RNA stage,4QR5G@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_192787_1 691965.D4P7C5_9CAUD 2.53e-94 294.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_328838_2 252305.OB2597_04600 2.5e-55 193.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2PCZV@252301|Oceanicola 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_273435_3 1609634.A0A0C5AFT2_9VIRU 2.16e-66 211.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_232640_1 1463936.JOJI01000043_gene7970 7.3e-13 79.7 COG3378@1|root,COG4643@1|root,COG3378@2|Bacteria,COG4643@2|Bacteria,2I36D@201174|Actinobacteria 201174|Actinobacteria L Phage plasmid primase P4 family - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A,DUF3854,Prim-Pol k59_86336_1 552811.Dehly_1157 8.61e-113 338.0 2DB9A@1|root,2Z7VI@2|Bacteria 2|Bacteria S Psort location Cytoplasmic, score - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - EcoRI_methylase,T5orf172 k59_381228_1 1327982.S0A2L1_9CAUD 3.51e-18 86.7 4QAIJ@10239|Viruses,4QVZ9@35237|dsDNA viruses no RNA stage,4QPXI@28883|Caudovirales,4QM02@10699|Siphoviridae 10699|Siphoviridae S C-5 cytosine-specific DNA methylase - - - - - - - - - - - - - k59_395256_2 545695.TREAZ_0592 5.35e-50 167.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - Dam,PhageMin_Tail k59_166239_1 984262.SGRA_0750 1.41e-06 50.1 COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,4NPZ7@976|Bacteroidetes 976|Bacteroidetes N Bacterial group 2 Ig-like protein - - - - - - - - - - - - Big_2,DUF4979 k59_34289_1 1173762.S4TT67_9CAUD 8.11e-69 224.0 4QCT5@10239|Viruses,4QYJH@35237|dsDNA viruses no RNA stage,4QTPG@28883|Caudovirales,4QNK2@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_155274_1 691965.D4P7D6_9CAUD 3.6e-34 134.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_88758_1 1227272.HMPREF1556_00522 1.38e-08 61.2 COG0587@1|root,COG0587@2|Bacteria,4NFA0@976|Bacteroidetes,2FNND@200643|Bacteroidia,22X3C@171551|Porphyromonadaceae 976|Bacteroidetes L DNA-directed DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_211089_1 1433126.BN938_2585 4.08e-54 184.0 COG0863@1|root,COG0863@2|Bacteria,4NID2@976|Bacteroidetes,2FV9W@200643|Bacteroidia 976|Bacteroidetes L DNA methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_6665_1 1609634.A0A0C5ANA6_9VIRU 0.000113 47.4 4QCA6@10239|Viruses,4QUMI@29258|ssDNA viruses,4QP4E@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_6665_2 1385658.U5KPZ6_9VIRU 1.42e-212 607.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_275867_1 1096546.WYO_0201 3.63e-77 256.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,2UQEG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_234826_1 644107.SL1157_2140 2.04e-11 70.9 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - PhageMin_Tail,TMP_2,Tape_meas_lam_C k59_319668_1 575540.Isop_2435 1.55e-115 357.0 COG5511@1|root,COG5511@2|Bacteria,2IZFA@203682|Planctomycetes 203682|Planctomycetes S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_22819_1 1476391.X5KCE1_9CAUD 4.31e-51 181.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_129581_2 309807.SRU_0026 0.000332 50.8 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,4NF8P@976|Bacteroidetes,1FIJX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_80257_1 450851.PHZ_c2212 2.45e-54 187.0 COG5323@1|root,COG5323@2|Bacteria,1R0EP@1224|Proteobacteria,2TYQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - - k59_384515_1 582899.Hden_1220 7.32e-11 72.8 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2TUGQ@28211|Alphaproteobacteria,3N8KY@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_80261_1 33876.JNXY01000007_gene8201 2e-27 112.0 28HRJ@1|root,2Z7YZ@2|Bacteria,2GKNT@201174|Actinobacteria,4D982@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_348159_2 1266925.JHVX01000002_gene715 3.67e-16 77.8 2A8Y6@1|root,30Y1U@2|Bacteria,1PJX1@1224|Proteobacteria,2W88U@28216|Betaproteobacteria,37484@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_161127_1 1217658.F987_02152 1.37e-12 68.9 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,1RQFD@1236|Gammaproteobacteria,3NJR9@468|Moraxellaceae 1236|Gammaproteobacteria S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_25578_1 1618238.A0A0C5IB41_9CIRC 1.67e-27 117.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_94028_1 1385658.U5KPZ6_9VIRU 1.29e-70 229.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_268968_2 1120919.AUBI01000001_gene2902 1.24e-37 140.0 COG3299@1|root,COG3299@2|Bacteria,1PYEJ@1224|Proteobacteria,2U8GE@28211|Alphaproteobacteria,2JVXG@204441|Rhodospirillales 204441|Rhodospirillales S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_254162_1 1618247.A0A0C5I2K0_9CIRC 1.06e-14 77.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_65441_1 145579.REP_BPPHM 9.6e-08 59.7 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_133343_1 6211.A0A068XXB6 1.83e-19 93.2 COG0086@1|root,KOG0261@2759|Eukaryota,38G14@33154|Opisthokonta,3BHIJ@33208|Metazoa,3CWUN@33213|Bilateria 33208|Metazoa K transcription by RNA polymerase III POLR3A GO:0000428,GO:0001817,GO:0001819,GO:0002376,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005666,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032479,GO:0032481,GO:0032648,GO:0032728,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045087,GO:0046483,GO:0048518,GO:0050789,GO:0050896,GO:0051239,GO:0051240,GO:0055029,GO:0061695,GO:0065007,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03018 ko00230,ko00240,ko01100,ko03020,ko04623,ko05169,map00230,map00240,map01100,map03020,map04623,map05169 M00181 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_173687_1 428125.CLOLEP_01409 1.02e-101 314.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_254169_2 1046714.AMRX01000006_gene3194 8.67e-08 57.4 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_224711_1 520709.F985_01890 1.41e-09 60.8 COG0270@1|root,COG0270@2|Bacteria,1N0XD@1224|Proteobacteria,1T05A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_416950_1 294631.Q5ZGF6_9CAUD 8.03e-56 186.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_374748_1 948071.S4S2N2_9CAUD 3.56e-21 96.7 4QH10@10239|Viruses,4QVVN@35237|dsDNA viruses no RNA stage,4QSY9@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_402155_1 1096546.WYO_0171 4.18e-37 142.0 COG0553@1|root,COG0553@2|Bacteria,1PXS8@1224|Proteobacteria,2UAZ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria KL COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_428702_1 1618248.A0A0C5IB82_9CIRC 3.02e-57 193.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_309457_1 767434.Fraau_1107 2.68e-05 55.8 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1X3XU@135614|Xanthomonadales 135614|Xanthomonadales O Cytochrome C biogenesis protein cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_402163_1 272942.RCAP_rcc02909 1.2e-13 69.7 2C095@1|root,32VKM@2|Bacteria,1N0Y9@1224|Proteobacteria,2UAGK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_149041_2 266940.Krad_4383 3.54e-42 146.0 COG1738@1|root,COG1738@2|Bacteria,2IGCP@201174|Actinobacteria 201174|Actinobacteria S Putative vitamin uptake transporter - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_149041_3 680198.SCAB_32881 4.29e-43 152.0 2EB9A@1|root,3359T@2|Bacteria,2INFV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_364915_1 43151.ADAC009269-PA 2.64e-09 60.8 2CMNT@1|root,2QR3D@2759|Eukaryota,39UHX@33154|Opisthokonta,3B9U3@33208|Metazoa,3D2YM@33213|Bilateria,4201I@6656|Arthropoda,3SMSN@50557|Insecta,44Z6J@7147|Diptera,45BTY@7148|Nematocera 33208|Metazoa G Peptidoglycan recognition protein PGRPLB GO:0000270,GO:0002376,GO:0002831,GO:0002832,GO:0003674,GO:0003824,GO:0004040,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009605,GO:0009607,GO:0009617,GO:0009966,GO:0009968,GO:0010646,GO:0010648,GO:0016787,GO:0016810,GO:0016811,GO:0023051,GO:0023057,GO:0030203,GO:0031347,GO:0031348,GO:0032101,GO:0032102,GO:0042742,GO:0042834,GO:0043170,GO:0043207,GO:0043900,GO:0043901,GO:0045087,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050830,GO:0050896,GO:0051704,GO:0051707,GO:0061058,GO:0061060,GO:0061783,GO:0065007,GO:0071704,GO:0080134,GO:0097367,GO:0098542,GO:1900424,GO:1900425,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K01446 - - R04112 RC00064,RC00141 ko00000 - - - Amidase_2 k59_243451_1 1294142.CINTURNW_3076 2.38e-16 89.4 COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,36EIZ@31979|Clostridiaceae 186801|Clostridia V PFAM VanW family protein vanW - - ko:K18346 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01504 - - - G5,PG_binding_4,VanW k59_55031_3 637730.C8XUN3_9CAUD 6.55e-16 75.5 4QF7D@10239|Viruses,4QX4V@35237|dsDNA viruses no RNA stage,4QR9K@28883|Caudovirales,4QKG0@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_243464_2 485918.Cpin_3834 1.68e-44 154.0 COG0270@1|root,COG0270@2|Bacteria,4NRFG@976|Bacteroidetes,1IY5U@117747|Sphingobacteriia 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_393211_1 1172188.KB911820_gene2887 7.24e-37 139.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4FFS1@85021|Intrasporangiaceae 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - - - - - - - - - - RecA k59_340107_2 1120944.JONS01000008_gene595 1.62e-05 52.8 COG2815@1|root,COG2815@2|Bacteria,2I5U6@201174|Actinobacteria,4D8BU@85005|Actinomycetales 201174|Actinobacteria S Excalibur calcium-binding domain - - - - - - - - - - - - Excalibur,PASTA k59_326582_2 1488328.JMCL01000129_gene2738 1.28e-27 109.0 2EKAM@1|root,33E0W@2|Bacteria,1MYSP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - RepL k59_204995_1 1233488.S4T7T5_9CAUD 2.22e-62 202.0 4QBQ9@10239|Viruses,4QVS0@35237|dsDNA viruses no RNA stage,4QPFB@28883|Caudovirales,4QNDC@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF4043) - - - - - - - - - - - - - k59_313479_1 1123508.JH636442_gene4475 2.66e-77 259.0 COG5525@1|root,COG5525@2|Bacteria,2IXN3@203682|Planctomycetes 203682|Planctomycetes S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_150805_1 648996.Theam_1826 2.44e-08 61.6 2DDXK@1|root,2ZJQC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_56613_1 279238.Saro_0647 5.51e-12 71.6 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,2K2QM@204457|Sphingomonadales 204457|Sphingomonadales S Phage portal protein - - - - - - - - - - - - Phage_portal k59_340116_2 55601.VANGNB10_cI1598c 3.66e-70 215.0 2DNA4@1|root,32WDI@2|Bacteria,1RH8K@1224|Proteobacteria,1S8YN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage tail tube, TTP, lambda-like - - - - - - - - - - - - Phage_TTP_11 k59_313496_1 1298858.AUEL01000029_gene95 1.67e-35 144.0 COG1345@1|root,COG1345@2|Bacteria,1QZZ9@1224|Proteobacteria,2TZSX@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Prophage tail length tape measure protein - - - - - - - - - - - - TMP_2 k59_420067_1 500632.CLONEX_00530 0.000152 44.7 COG3773@1|root,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,24912@186801|Clostridia 186801|Clostridia M Cell wall hydrolase - - 3.5.1.28 ko:K01449 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Hydrolase_2,PG_binding_1 k59_420067_4 742725.HMPREF9450_00200 4.98e-42 172.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia,22U0S@171550|Rikenellaceae 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_420067_7 1175654.A0A0S0MVN0_9CAUD 3.37e-45 164.0 4QFED@10239|Viruses,4R072@35237|dsDNA viruses no RNA stage,4QPEH@28883|Caudovirales,4QN2V@10699|Siphoviridae 10699|Siphoviridae S tRNA modification - - - - - - - - - - - - - k59_420067_8 994479.GL877879_gene5490 6.8e-10 62.0 COG1738@1|root,COG1738@2|Bacteria,2IGCP@201174|Actinobacteria,4E77R@85010|Pseudonocardiales 201174|Actinobacteria S Putative vitamin uptake transporter - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_420067_10 986075.CathTA2_1618 4.49e-51 174.0 COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,4HAXS@91061|Bacilli 91061|Bacilli F gtp cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_420067_12 1540098.A0A0A0RTJ1_9CAUD 6.1e-41 146.0 4QCT7@10239|Viruses,4QPFU@28883|Caudovirales,4QKS9@10699|Siphoviridae 10699|Siphoviridae S iron-sulfur cluster binding - - - - - - - - - - - - - k59_420067_14 1408428.JNJP01000012_gene1150 8.05e-13 74.3 COG1468@1|root,COG1468@2|Bacteria,1QZ2Y@1224|Proteobacteria,43DCE@68525|delta/epsilon subdivisions,2X8IE@28221|Deltaproteobacteria 28221|Deltaproteobacteria L defense response to virus - - - - - - - - - - - - - k59_420067_16 414684.RC1_0046 2.39e-06 55.5 COG1100@1|root,COG1100@2|Bacteria,1N5QS@1224|Proteobacteria,2TSKW@28211|Alphaproteobacteria,2JW5C@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain - - - - - - - - - - - - AAA_24 k59_420067_17 1449976.KALB_4068 1.34e-41 148.0 COG0603@1|root,COG0603@2|Bacteria,2I8NZ@201174|Actinobacteria,4E21X@85010|Pseudonocardiales 201174|Actinobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_56748_1 11082.PRO_0000037753 4.15e-112 360.0 4QBXT@10239|Viruses,4R138@439488|ssRNA viruses,4R0R1@35278|ssRNA positive-strand viruses no DNA stage 10239|Viruses K ATP-dependent helicase activity - GO:0000122,GO:0001172,GO:0001510,GO:0001558,GO:0001817,GO:0001818,GO:0001932,GO:0001933,GO:0001934,GO:0001959,GO:0001960,GO:0001961,GO:0002039,GO:0002673,GO:0002674,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002791,GO:0002792,GO:0002831,GO:0002832,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0003824,GO:0003968,GO:0004175,GO:0004252,GO:0004483,GO:0005102,GO:0005124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005793,GO:0006139,GO:0006355,GO:0006357,GO:0006396,GO:0006417,GO:0006508,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0007155,GO:0007159,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008174,GO:0008233,GO:0008236,GO:0008270,GO:0008284,GO:0008285,GO:0008757,GO:0009058,GO:0009059,GO:0009451,GO:0009452,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010692,GO:0010694,GO:0010803,GO:0010804,GO:0010821,GO:0010823,GO:0010921,GO:0010922,GO:0010941,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016070,GO:0016071,GO:0016192,GO:0016462,GO:0016556,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017016,GO:0017111,GO:0017137,GO:0017151,GO:0017171,GO:0018130,GO:0018995,GO:0019048,GO:0019049,GO:0019050,GO:0019054,GO:0019056,GO:0019058,GO:0019065,GO:0019068,GO:0019080,GO:0019082,GO:0019215,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019899,GO:0019900,GO:0019902,GO:0019903,GO:0020012,GO:0022610,GO:0023051,GO:0023056,GO:0023057,GO:0030162,GO:0030234,GO:0030260,GO:0030307,GO:0030430,GO:0030682,GO:0030683,GO:0030888,GO:0030889,GO:0031072,GO:0031090,GO:0031267,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031330,GO:0031347,GO:0031348,GO:0031369,GO:0031399,GO:0031400,GO:0031401,GO:0031952,GO:0031953,GO:0032069,GO:0032074,GO:0032101,GO:0032102,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032465,GO:0032467,GO:0032675,GO:0032715,GO:0032774,GO:0032780,GO:0032879,GO:0032880,GO:0032944,GO:0032945,GO:0032991,GO:0032993,GO:0033036,GO:0033043,GO:0033116,GO:0033592,GO:0033643,GO:0033644,GO:0033645,GO:0033646,GO:0033647,GO:0033648,GO:0033650,GO:0033655,GO:0033662,GO:0033663,GO:0033668,GO:0033673,GO:0034062,GO:0034121,GO:0034122,GO:0034135,GO:0034136,GO:0034143,GO:0034144,GO:0034155,GO:0034156,GO:0034163,GO:0034164,GO:0034248,GO:0034250,GO:0034641,GO:0034654,GO:0035303,GO:0035306,GO:0035325,GO:0035663,GO:0035821,GO:0036260,GO:0036265,GO:0039502,GO:0039503,GO:0039506,GO:0039507,GO:0039513,GO:0039516,GO:0039526,GO:0039527,GO:0039547,GO:0039560,GO:0039580,GO:0039584,GO:0039612,GO:0039613,GO:0039644,GO:0039653,GO:0039656,GO:0039657,GO:0039713,GO:0039714,GO:0040008,GO:0042000,GO:0042025,GO:0042127,GO:0042287,GO:0042288,GO:0042325,GO:0042326,GO:0042327,GO:0042509,GO:0042532,GO:0042802,GO:0042886,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043086,GO:0043122,GO:0043123,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043414,GO:0043462,GO:0043487,GO:0043489,GO:0043549,GO:0043656,GO:0043657,GO:0043900,GO:0043901,GO:0043902,GO:0043903,GO:0044003,GO:0044053,GO:0044068,GO:0044092,GO:0044093,GO:0044164,GO:0044165,GO:0044167,GO:0044177,GO:0044186,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044220,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044279,GO:0044359,GO:0044362,GO:0044403,GO:0044409,GO:0044413,GO:0044414,GO:0044415,GO:0044417,GO:0044419,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0044531,GO:0044532,GO:0044766,GO:0044833,GO:0044877,GO:0045069,GO:0045070,GO:0045088,GO:0045184,GO:0045727,GO:0045787,GO:0045824,GO:0045862,GO:0045892,GO:0045927,GO:0045934,GO:0045936,GO:0045937,GO:0046425,GO:0046426,GO:0046483,GO:0046718,GO:0046755,GO:0046762,GO:0046774,GO:0046794,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0048583,GO:0048584,GO:0048585,GO:0050670,GO:0050672,GO:0050687,GO:0050688,GO:0050689,GO:0050690,GO:0050691,GO:0050708,GO:0050709,GO:0050727,GO:0050728,GO:0050730,GO:0050732,GO:0050776,GO:0050777,GO:0050789,GO:0050790,GO:0050792,GO:0050794,GO:0050864,GO:0050865,GO:0050866,GO:0050869,GO:0050896,GO:0051020,GO:0051046,GO:0051047,GO:0051048,GO:0051049,GO:0051050,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051253,GO:0051302,GO:0051336,GO:0051338,GO:0051345,GO:0051346,GO:0051348,GO:0051701,GO:0051704,GO:0051707,GO:0051726,GO:0051781,GO:0051805,GO:0051806,GO:0051807,GO:0051808,GO:0051817,GO:0051828,GO:0051832,GO:0051833,GO:0051834,GO:0051836,GO:0052026,GO:0052027,GO:0052029,GO:0052031,GO:0052037,GO:0052038,GO:0052040,GO:0052041,GO:0052053,GO:0052055,GO:0052056,GO:0052148,GO:0052150,GO:0052167,GO:0052170,GO:0052173,GO:0052199,GO:0052200,GO:0052203,GO:0052204,GO:0052205,GO:0052230,GO:0052248,GO:0052250,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052312,GO:0052433,GO:0052490,GO:0052493,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060147,GO:0060149,GO:0060255,GO:0060338,GO:0060339,GO:0060341,GO:0060548,GO:0060589,GO:0060590,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0060759,GO:0060760,GO:0060761,GO:0060966,GO:0060967,GO:0060968,GO:0060969,GO:0065007,GO:0065008,GO:0065009,GO:0070011,GO:0070103,GO:0070104,GO:0070201,GO:0070486,GO:0070663,GO:0070664,GO:0071593,GO:0071702,GO:0071704,GO:0071705,GO:0072583,GO:0075109,GO:0075111,GO:0075112,GO:0075114,GO:0075136,GO:0075344,GO:0075509,GO:0075512,GO:0075528,GO:0080009,GO:0080090,GO:0080134,GO:0080135,GO:0090068,GO:0090087,GO:0090199,GO:0090201,GO:0090304,GO:0097159,GO:0097617,GO:0097659,GO:0097677,GO:0097747,GO:0098588,GO:0098609,GO:0098657,GO:0098772,GO:0106005,GO:0140096,GO:0140098,GO:1900101,GO:1900102,GO:1900117,GO:1900118,GO:1900368,GO:1900369,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1902369,GO:1902531,GO:1902532,GO:1902533,GO:1902579,GO:1902679,GO:1903265,GO:1903506,GO:1903507,GO:1903530,GO:1903531,GO:1903573,GO:1903719,GO:1903721,GO:1903900,GO:1903902,GO:1904892,GO:1904893,GO:1904950,GO:1905897,GO:1990214,GO:1990216,GO:1990219,GO:1990254,GO:1990814,GO:1990904,GO:2000112,GO:2000113,GO:2001141,GO:2001233,GO:2001234 - - - - - - - - - - - k59_150884_1 691965.D4P7L8_9CAUD 1.44e-20 84.3 4QCXV@10239|Viruses,4QWTS@35237|dsDNA viruses no RNA stage,4QSWS@28883|Caudovirales,4QN14@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_150884_2 691965.D4P7L7_9CAUD 1.23e-273 790.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_150884_3 742733.HMPREF9469_05040 1.89e-63 201.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,221XY@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_150884_4 428125.CLOLEP_01398 4.65e-32 115.0 2CGGB@1|root,32UNH@2|Bacteria,1VD9W@1239|Firmicutes,24MWC@186801|Clostridia,3WPKG@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_150884_6 691965.D4P7L3_9CAUD 8.03e-149 439.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage,4QQ8R@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_355437_2 1035308.AQYY01000001_gene1935 1.55e-80 256.0 COG1875@1|root,COG1875@2|Bacteria,1UHTD@1239|Firmicutes,25ED1@186801|Clostridia,2609S@186807|Peptococcaceae 186801|Clostridia T PFAM PhoH-like protein - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_58180_1 1123242.JH636434_gene3431 1.12e-06 55.5 COG1475@1|root,COG1475@2|Bacteria,2IZ8P@203682|Planctomycetes 203682|Planctomycetes K DNA binding - - - - - - - - - - - - ParBc k59_179293_2 29306.JOBE01000027_gene2228 1.11e-27 110.0 2FB4K@1|root,343AZ@2|Bacteria,2IN2Y@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_273031_1 1788447.A0A190WHJ9_9CIRC 1.14e-06 50.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_328499_1 5786.XP_003294292.1 1.8e-92 297.0 COG1372@1|root,2QRRC@2759|Eukaryota,3XA2K@554915|Amoebozoa 554915|Amoebozoa F reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_260364_1 1150399.AQYK01000001_gene655 8.61e-16 72.4 arCOG05626@1|root,2Z9D9@2|Bacteria,2IIAB@201174|Actinobacteria,4FS1R@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_232285_1 582899.Hden_1166 2.83e-92 277.0 COG0175@1|root,COG0175@2|Bacteria,1R52W@1224|Proteobacteria,2U0Y4@28211|Alphaproteobacteria,3N7GH@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria EH COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes - - - - - - - - - - - - PAPS_reduct k59_44137_2 411902.CLOBOL_04320 2.36e-41 147.0 COG4725@1|root,COG4725@2|Bacteria,1TSJV@1239|Firmicutes,248X5@186801|Clostridia,21ZSS@1506553|Lachnoclostridium 186801|Clostridia KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_355448_1 665956.HMPREF1032_00686 2.08e-115 378.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,3WN92@541000|Ruminococcaceae 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_368245_1 198110.B3FJ92_9CAUD 3.18e-07 57.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QJCH@10662|Myoviridae 10662|Myoviridae S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_152502_1 1395983.A0A067Y0B2_9CAUD 1.38e-28 115.0 4QBY0@10239|Viruses,4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_421567_1 1484460.JSWG01000008_gene1877 1.46e-23 92.4 2DQZ7@1|root,339HS@2|Bacteria,4NXDK@976|Bacteroidetes,1I5MY@117743|Flavobacteriia 976|Bacteroidetes S Helix-turn-helix domain - - - - - - - - - - - - HTH_17 k59_421567_2 1492737.FEM08_02810 4.07e-27 110.0 COG0467@1|root,COG0467@2|Bacteria,4PK66@976|Bacteroidetes,1INEQ@117743|Flavobacteriia,2NZBJ@237|Flavobacterium 976|Bacteroidetes T Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - - - - - - - - - - - k59_140285_1 981085.XP_010099169.1 3.68e-12 65.1 COG0495@1|root,KOG0435@2759|Eukaryota,37NXR@33090|Viridiplantae,3GDEX@35493|Streptophyta,4JMEF@91835|fabids 35493|Streptophyta J Belongs to the class-I aminoacyl-tRNA synthetase family - GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032543,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0071704,GO:0090304,GO:0140053,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_140285_2 504487.JCM19302_2167 2.66e-17 82.8 COG5267@1|root,COG5267@2|Bacteria,4NJBN@976|Bacteroidetes,1I0QW@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_260591_1 742725.HMPREF9450_00879 1.37e-39 147.0 COG0305@1|root,COG0305@2|Bacteria,4P0VD@976|Bacteroidetes,2FMKK@200643|Bacteroidia 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2,Toprim_4 k59_260591_2 1031288.AXAA01000044_gene1970 1.18e-19 87.0 2DPZ6@1|root,3341A@2|Bacteria,1VDMQ@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_17509_2 438753.AZC_3597 1.36e-30 122.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase family A - - - - - - - - - - - - DNA_pol_A k59_273251_2 443144.GM21_1645 2.17e-05 53.5 COG1216@1|root,COG1216@2|Bacteria,1N2VJ@1224|Proteobacteria,43C4Q@68525|delta/epsilon subdivisions,2WREQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1,Glycos_transf_2 k59_58381_2 1485544.JQKP01000008_gene1698 1.96e-20 89.4 2E16H@1|root,32WMB@2|Bacteria,1N6EU@1224|Proteobacteria,2W5PA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_100449_1 242861.Q6UYH1_9CAUD 2.27e-16 74.3 4QB07@10239|Viruses,4QUZW@35237|dsDNA viruses no RNA stage,4QPGS@28883|Caudovirales,4QMBY@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF4326) - - - - - - - - - - - - - k59_357782_1 948071.S4S2D9_9CAUD 3.35e-116 359.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_181092_1 391038.Bphy_1861 3.01e-46 160.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2VUEJ@28216|Betaproteobacteria,1K8Z8@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_396281_1 1414766.A0A0A0P0H0_9VIRU 1.14e-13 70.9 4QH92@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_410697_2 470.IX87_13220 6.52e-05 47.8 2EK02@1|root,33DQM@2|Bacteria,1NKQA@1224|Proteobacteria,1SJBA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_87741_1 1173762.S4TP28_9CAUD 5.58e-82 269.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_358052_2 1541960.KQ78_02166 2.55e-06 52.0 COG0749@1|root,COG0749@2|Bacteria,3WV5B@544448|Tenericutes 544448|Tenericutes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A k59_262541_1 1137269.AZWL01000006_gene6864 5.81e-43 164.0 COG0358@1|root,COG0358@2|Bacteria,2I620@201174|Actinobacteria 201174|Actinobacteria L Protein of unknown function (DUF3987) - - - - - - - - - - - - DUF3987,Toprim_3 k59_262541_3 321955.AAGP01000010_gene399 1.5e-30 115.0 COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4F9IJ@85019|Brevibacteriaceae 201174|Actinobacteria L Single-strand binding protein family ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_318205_1 595536.ADVE02000001_gene3154 2.69e-08 59.3 COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria,370VB@31993|Methylocystaceae 28211|Alphaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06952 - - - - ko00000 - - - - k59_329860_1 1157943.KB892705_gene2039 2.38e-60 201.0 COG3969@1|root,COG3969@2|Bacteria,2H4MT@201174|Actinobacteria 201174|Actinobacteria S Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_288549_1 1120956.JHZK01000006_gene654 2.38e-28 110.0 COG3428@1|root,COG3428@2|Bacteria,1RHA4@1224|Proteobacteria,2UA6D@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial PH domain puhB - - - - - - - - - - - bPH_2 k59_75547_1 742740.HMPREF9474_02303 3.28e-122 397.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,221YV@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_126278_1 318464.IO99_00635 3.77e-05 56.2 COG5281@1|root,COG5281@2|Bacteria,1TPWF@1239|Firmicutes,24A8R@186801|Clostridia,36GW3@31979|Clostridiaceae 186801|Clostridia S tape measure - - - - - - - - - - - - - k59_274650_2 1049564.TevJSym_ac00860 3.29e-20 90.1 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_19452_2 458639.A7KV45_9CAUD 1.22e-08 62.8 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIM4@10662|Myoviridae 10662|Myoviridae S N-acetyltransferase activity - - - - - - - - - - - - - k59_33475_1 656024.FsymDg_1287 4.81e-12 69.7 COG3355@1|root,COG3355@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - EIIA-man,HTH_36,PAS_4,PRD,ROK,Sigma54_activat k59_142936_1 1267534.KB906754_gene2849 6.04e-31 125.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,3Y3X3@57723|Acidobacteria,2JHXN@204432|Acidobacteriia 204432|Acidobacteriia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_113278_1 314282.PCNPT3_01495 2.91e-23 104.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,2QHH0@267894|Psychromonadaceae 1236|Gammaproteobacteria F Cytidylyltransferase-like hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272,ko:K21344 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iPC815.YPO0654,iZ_1308.Z4405 CTP_transf_like,PfkB k59_75558_2 1379709.S5TMV0_9CIRC 5.28e-21 98.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_5524_2 331869.BAL199_07328 1.04e-15 78.2 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,4BS5N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M TPR repeat - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_347250_1 145579.H_BPPHM 1.44e-07 56.2 4QCA6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_347250_2 105154.Q9MBU6_9VIRU 3.08e-76 244.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_102988_3 1088721.NSU_0776 0.000154 45.4 2DNU8@1|root,32Z5M@2|Bacteria,1RGT6@1224|Proteobacteria,2UJGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_169448_1 981335.G4W934_9CAUD 2.62e-44 153.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_383898_2 1121943.KB900008_gene1991 6.94e-37 142.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1R97W@1224|Proteobacteria 1224|Proteobacteria D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_35825_1 171101.spr1655 1.06e-07 60.5 COG2148@1|root,COG2148@2|Bacteria,1TP7V@1239|Firmicutes,4HGEA@91061|Bacilli,1WUZZ@1313|Streptococcus pneumoniae 91061|Bacilli M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf k59_21903_1 691965.D4P7C5_9CAUD 1.99e-172 502.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_21903_2 428125.CLOLEP_01411 3.56e-58 202.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,3WNJZ@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_371733_1 1499967.BAYZ01000123_gene2521 2.19e-05 52.8 COG1649@1|root,COG3023@1|root,COG3291@1|root,COG1649@2|Bacteria,COG3023@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23 ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197 ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142 M00076,M00077 R04018,R07824,R07825,R10905,R11309 RC00028,RC00077 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - GH33,GH66,PL11 - GHL10,Glyco_hydro_20b,NAGidase,PKD k59_425155_1 1692242.A0A0K1RL37_9CIRC 1.25e-47 168.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_196444_1 1051675.G0YQG4_9CAUD 2.62e-34 134.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_347529_1 1229276.DI53_1624 3.25e-63 202.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,1IYYG@117747|Sphingobacteriia 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_79426_2 529507.PMI0485 5.15e-23 91.7 2D7I9@1|root,32TP3@2|Bacteria,1N2ZM@1224|Proteobacteria,1S9DB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phage protein ybcO - - - - - - - - - - - DUF1364 k59_277257_1 1274524.BSONL12_06063 2.53e-89 290.0 COG5545@1|root,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,4HCHZ@91061|Bacilli,1ZDD8@1386|Bacillus 91061|Bacilli L Virulence-associated protein E - - - - - - - - - - - - VirE k59_103216_1 938709.AUSH02000027_gene1961 1.42e-09 69.3 COG3405@1|root,COG4886@1|root,COG3405@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus - - - - - - - - - - - - Big_2,CBM_15,CHU_C,DUF11,Flg_new,I-set,Laminin_G_3,fn3 k59_265476_1 10689.H9C0G6_BPCPT 9.42e-54 182.0 4QAMU@10239|Viruses,4QV4U@35237|dsDNA viruses no RNA stage,4QPEV@28883|Caudovirales,4QI0J@10662|Myoviridae 10662|Myoviridae S Baseplate J-like protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_129039_1 1123008.KB905697_gene3236 6.81e-12 72.8 COG3210@1|root,COG3210@2|Bacteria,4PPCP@976|Bacteroidetes 976|Bacteroidetes U Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_293585_2 1187128.I2GUJ6_9CAUD 2.74e-14 71.2 4QB0C@10239|Viruses,4QW7S@35237|dsDNA viruses no RNA stage,4QPK3@28883|Caudovirales,4QI2J@10662|Myoviridae 10662|Myoviridae S Endodeoxyribonuclease RusA - - - - - - - - - - - - - k59_50595_1 411902.CLOBOL_06312 6.86e-13 76.3 COG5362@1|root,COG5362@2|Bacteria,1TSQB@1239|Firmicutes,24ACE@186801|Clostridia,221MX@1506553|Lachnoclostridium 186801|Clostridia S TIGRFAM Phage - - - - - - - - - - - - - k59_400536_1 1692244.A0A0K1RLR5_9CIRC 2.4e-47 166.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_92513_1 572480.Arnit_0131 8.28e-14 68.6 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions 1224|Proteobacteria F PFAM CMP dCMP deaminase zinc-binding comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_92513_2 318424.EU78_13715 2.27e-18 89.4 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,232S7@1762|Mycobacteriaceae 201174|Actinobacteria IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_278978_1 411460.RUMTOR_01340 6.88e-26 100.0 2ECB3@1|root,3369E@2|Bacteria,1VEV9@1239|Firmicutes,24R69@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_278978_2 411460.RUMTOR_01339 6.87e-25 98.2 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_267493_1 345341.KUTG_01907 4.38e-90 274.0 COG0500@1|root,COG2226@2|Bacteria,2IGXK@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_104990_1 1273711.A0A096VKE4_9CAUD 2.49e-27 112.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QNBW@10744|Podoviridae 10744|Podoviridae S DNA helicase activity - - - - - - - - - - - - - k59_349861_3 742766.HMPREF9455_03134 3.19e-26 102.0 2AEBE@1|root,3145V@2|Bacteria,4NZAM@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_215477_1 649747.HMPREF0083_03347 4.91e-72 228.0 COG0330@1|root,COG0330@2|Bacteria,1UZJK@1239|Firmicutes,4HGVU@91061|Bacilli,26RE7@186822|Paenibacillaceae 91061|Bacilli O HflC protein - - - - - - - - - - - - Band_7 k59_104994_1 345201.VF268_IIV3 5.36e-87 281.0 4QEK9@10239|Viruses,4QUY5@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_24173_1 1110502.TMO_0047 1.85e-23 105.0 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_252916_1 1217710.F969_02493 1.52e-51 176.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1S5J8@1236|Gammaproteobacteria,3NM1I@468|Moraxellaceae 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_131381_5 948565.AFFP02000005_gene505 1.82e-13 72.0 2DW9P@1|root,32V14@2|Bacteria,1R3JI@1224|Proteobacteria,1T68V@1236|Gammaproteobacteria,1YB1K@135625|Pasteurellales 135625|Pasteurellales - - - - - - - - - - - - - - - k59_175312_3 38033.XP_001219967.1 4.7e-11 70.1 2ECWC@1|root,2SINF@2759|Eukaryota,39VYZ@33154|Opisthokonta,3P0FH@4751|Fungi,3QSDA@4890|Ascomycota,21NSZ@147550|Sordariomycetes,3UB1M@5139|Sordariales,3HGJE@35718|Chaetomiaceae 4751|Fungi S Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_282031_2 1229485.AMYV01000023_gene3046 6.46e-30 122.0 COG4228@1|root,COG4228@2|Bacteria,1R4HU@1224|Proteobacteria,1RPRY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA circulation protein - - - - - - - - - - - - DNA_circ_N k59_402774_2 1455075.W6PP19_9CAUD 1.33e-15 76.3 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_375593_2 1123058.KB894219_gene156 1.58e-19 86.3 COG2852@1|root,COG2852@2|Bacteria,4NX7B@976|Bacteroidetes 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - - k59_175324_2 1301098.PKB_5013 2.65e-07 54.3 2EFJA@1|root,339BN@2|Bacteria,1NFD8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_402792_1 743299.Acife_1995 1.1e-50 174.0 COG3969@1|root,COG3969@2|Bacteria,1NBDM@1224|Proteobacteria,1RYRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoadenosine phosphosulfate ybdN - - - - - - - - - - - DUF3440,PAPS_reduct k59_282049_2 1122918.KB907249_gene3868 1.2e-17 90.9 COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE6D@91061|Bacilli,26RGF@186822|Paenibacillaceae 91061|Bacilli M enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_134650_1 1121378.KB899726_gene4386 1.41e-50 189.0 COG0553@1|root,COG0553@2|Bacteria,1WNE4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair - - - - - - - - - - - - Helicase_C,SNF2_N k59_225594_1 1165094.RINTHH_3920 4.94e-47 164.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_119863_1 1399774.JDWH01000007_gene1634 1.96e-35 124.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_430114_2 38033.XP_001223727.1 0.000218 48.1 2CYSS@1|root,2S670@2759|Eukaryota,3ASIZ@33154|Opisthokonta,3Q4MX@4751|Fungi,3RMWP@4890|Ascomycota,217CH@147550|Sordariomycetes,3U6Z2@5139|Sordariales,3HAJ6@35718|Chaetomiaceae 4751|Fungi S Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation - - - ko:K18732 - - - - ko00000,ko03019 - - - SAP k59_387493_1 279280.Q6J1S4_9CAUD 4.3e-14 79.0 4QG38@10239|Viruses,4QY33@35237|dsDNA viruses no RNA stage,4QQVI@28883|Caudovirales,4QNWM@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_67240_1 1088868.CIN_21470 8.72e-06 52.8 COG0270@1|root,COG0270@2|Bacteria,1NPQG@1224|Proteobacteria,2U226@28211|Alphaproteobacteria 28211|Alphaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_403373_1 530564.Psta_2746 5.9e-29 125.0 COG0358@1|root,COG0467@1|root,COG0358@2|Bacteria,COG0467@2|Bacteria,2J0EJ@203682|Planctomycetes 203682|Planctomycetes T AAA domain - - - - - - - - - - - - AAA_25 k59_255865_1 1788438.A0A190WHE1_9CIRC 2.89e-06 53.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_376262_1 420246.GTNG_3101 3.25e-53 192.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,1WF2M@129337|Geobacillus 91061|Bacilli M Subtilase family - - - ko:K13277 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8,SLH k59_176676_1 226186.BT_2026 6.39e-17 82.8 2DR9Y@1|root,33AUY@2|Bacteria,4NZ4B@976|Bacteroidetes,2FQRH@200643|Bacteroidia,4APD1@815|Bacteroidaceae 976|Bacteroidetes L HNH endonuclease domain protein - - - - - - - - - - - - HNH_3,NUMOD4 k59_95894_1 1122609.AUGT01000009_gene3154 2.74e-08 60.8 COG0308@1|root,COG1409@1|root,COG4932@1|root,COG0308@2|Bacteria,COG1409@2|Bacteria,COG4932@2|Bacteria,2GXWA@201174|Actinobacteria,4DUCA@85009|Propionibacteriales 201174|Actinobacteria M Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - B_lectin,CarboxypepD_reg,Peptidase_M23,SASA k59_312312_1 948071.S4S2D9_9CAUD 9.26e-95 299.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_419405_1 1406840.Q763_17105 4.46e-78 248.0 28KN5@1|root,2ZA6E@2|Bacteria,4NIXS@976|Bacteroidetes,1ICTE@117743|Flavobacteriia,2NUM9@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_190279_1 391009.Tmel_1524 2.03e-06 56.2 COG0587@1|root,COG0587@2|Bacteria,2GC62@200918|Thermotogae 200918|Thermotogae L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6 k59_95903_1 1567485.A0A0B4SK08_9CAUD 5.69e-15 81.3 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_82614_1 1313172.YM304_19620 1.41e-122 384.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_257944_2 194966.Q7Y5M4_BPSP6 1.66e-37 130.0 4QB6G@10239|Viruses,4QVYX@35237|dsDNA viruses no RNA stage,4QQS8@28883|Caudovirales,4QNR7@10744|Podoviridae 10744|Podoviridae S Peptidase M15 - - - - - - - - - - - - - k59_1589_1 1121447.JONL01000012_gene3405 2.19e-46 175.0 COG0503@1|root,COG2518@1|root,COG0503@2|Bacteria,COG2518@2|Bacteria 2|Bacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins apt - 2.1.1.163,2.1.1.201,2.1.1.77,2.4.2.7 ko:K00573,ko:K00759,ko:K03183,ko:K07003 ko00130,ko00230,ko01100,ko01110,map00130,map00230,map01100,map01110 M00116,M00117 R00190,R01229,R04378,R04990,R04993,R06859,R08774,R09736 RC00003,RC00063,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000,ko04147 - - - DUF3560,Methyltransf_21,Pribosyltran k59_109454_1 233412.HD_0962 2.67e-09 58.5 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1Y8UH@135625|Pasteurellales 135625|Pasteurellales L Single-strand binding protein family - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_176883_1 643473.KB235930_gene3744 2.89e-67 218.0 COG0343@1|root,COG0343@2|Bacteria,1GAUU@1117|Cyanobacteria,1HS8U@1161|Nostocales 1117|Cyanobacteria J queuine tRNA-ribosyltransferase activity - - - - - - - - - - - - TGT k59_206138_1 1120971.AUCA01000053_gene370 2.33e-70 223.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4HTYH@91061|Bacilli 91061|Bacilli KL DEAD-like helicases superfamily - - - - - - - - - - - - - k59_420797_2 1123008.KB905705_gene955 1.31e-19 84.0 2C8RN@1|root,32RMQ@2|Bacteria,4NSD0@976|Bacteroidetes,2FVDC@200643|Bacteroidia,231FC@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_110992_2 1206735.BAGG01000266_gene7074 1.86e-21 95.9 2EGUB@1|root,33AKH@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_110992_3 1123511.KB905846_gene2609 2.19e-15 75.5 COG3935@1|root,COG3935@2|Bacteria,1TSHD@1239|Firmicutes,4H9J6@909932|Negativicutes 909932|Negativicutes L DnaD domain protein - - - - - - - - - - - - - k59_84804_1 1169161.KB897730_gene1072 9.91e-87 264.0 28HRJ@1|root,2Z7YZ@2|Bacteria,2GKNT@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_354697_2 1158762.KB898037_gene2126 7.87e-36 134.0 28K97@1|root,2Z9WV@2|Bacteria,1MWWR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_354697_6 102129.Lepto7375DRAFT_7273 1.23e-15 75.1 2EHVE@1|root,33BKZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_354697_11 861044.E0YPX3_9CAUD 3.47e-24 117.0 4QAY9@10239|Viruses,4QV7W@35237|dsDNA viruses no RNA stage,4QPAN@28883|Caudovirales,4QKV1@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_354697_14 548477.HMPREF0294_0800 1.22e-47 184.0 COG0507@1|root,COG0507@2|Bacteria,2HH79@201174|Actinobacteria,22KNF@1653|Corynebacteriaceae 201174|Actinobacteria L PIF1-like helicase - - - - - - - - - - - - PIF1 k59_246201_1 1437329.A0A0A8KWW5_9CAUD 2.72e-29 116.0 4QARC@10239|Viruses,4QV4E@35237|dsDNA viruses no RNA stage,4QPDS@28883|Caudovirales,4QP0H@10744|Podoviridae 10744|Podoviridae S nucleic acid binding - - - - - - - - - - - - - k59_16717_1 1038860.AXAP01000067_gene8427 3.45e-82 262.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_110998_1 313612.L8106_08721 1.59e-157 452.0 COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales 1117|Cyanobacteria J PFAM tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_139093_1 1395516.PMO01_03075 2.76e-28 112.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,1SCZN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - AP2,HNH_3 k59_206376_1 570952.ATVH01000014_gene2306 4.12e-58 188.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,rve,rve_3 k59_314892_1 428125.CLOLEP_01415 2.25e-75 233.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia,3WNFY@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_300017_1 360095.BARBAKC583_1070 3.93e-67 214.0 COG3561@1|root,COG3645@1|root,COG3561@2|Bacteria,COG3645@2|Bacteria,1N1AT@1224|Proteobacteria,2VGCW@28211|Alphaproteobacteria,48UN0@772|Bartonellaceae 28211|Alphaproteobacteria K Phage antirepressor protein KilAC domain - - - ko:K07741 - - - - ko00000 - - - ANT,AntA k59_300017_2 279006.D9I5X4_9CAUD 3.74e-37 133.0 4QAZY@10239|Viruses,4QV2T@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI2A@10662|Myoviridae 10662|Myoviridae S N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - - k59_300017_4 716541.ECL_02831 1.74e-09 61.2 COG2110@1|root,COG2110@2|Bacteria,1R01E@1224|Proteobacteria,1T4DI@1236|Gammaproteobacteria,3X45A@547|Enterobacter 1236|Gammaproteobacteria S Caudovirales tail fibre assembly protein, lambda gpK - - - - - - - - - - - - Caudo_TAP k59_300017_5 744980.TRICHSKD4_2313 1.11e-17 89.4 COG4675@1|root,COG4675@2|Bacteria,1N0FZ@1224|Proteobacteria,2UDXB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_354707_2 756272.Plabr_2550 6.04e-10 64.3 COG2165@1|root,COG2165@2|Bacteria,2J1H8@203682|Planctomycetes 203682|Planctomycetes NU TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - - - - - - - - - - N_methyl k59_125687_2 880073.Calab_1466 3.46e-25 103.0 COG3023@1|root,COG3023@2|Bacteria,2NRUX@2323|unclassified Bacteria 2|Bacteria V SPTR N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD - - - - - - - - - - - - Amidase_2,LysM,PG_binding_1 k59_125687_5 224308.BSU21550 7.17e-10 62.8 COG1670@1|root,COG1670@2|Bacteria,1UUXI@1239|Firmicutes,4I685@91061|Bacilli,1ZHU0@1386|Bacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_125687_7 357809.Cphy_1373 7.41e-36 142.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,21YSB@1506553|Lachnoclostridium 186801|Clostridia H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_166763_1 292.DM42_4024 2.93e-21 97.1 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,2VIPB@28216|Betaproteobacteria,1K5WQ@119060|Burkholderiaceae 28216|Betaproteobacteria S terminase GpA - - 3.1.21.4 ko:K21512 - - - - ko00000,ko01000 - - - Terminase_GpA k59_166763_3 398527.Bphyt_1172 2.77e-05 48.9 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2VKKT@28216|Betaproteobacteria,1K1WU@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_410039_1 43989.cce_3420 1.2e-30 124.0 COG0469@1|root,COG0469@2|Bacteria,1G1IY@1117|Cyanobacteria,3KGFY@43988|Cyanothece 1117|Cyanobacteria G Belongs to the pyruvate kinase family pykF GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k59_410039_2 859194.MHF_0277 3.49e-14 73.2 COG0126@1|root,COG0126@2|Bacteria,3WSUW@544448|Tenericutes 544448|Tenericutes F belongs to the phosphoglycerate kinase family pgk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_32592_1 595536.ADVE02000001_gene3060 6.7e-19 93.6 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2TU4W@28211|Alphaproteobacteria,36Z5E@31993|Methylocystaceae 28211|Alphaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_317284_1 1385658.U5KNR1_9VIRU 2.03e-29 119.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_4824_1 290398.Csal_2578 2.01e-05 50.4 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XIT9@135619|Oceanospirillales 135619|Oceanospirillales E phosphoserine phosphatase - - - - - - - - - - - - HAD k59_343751_1 1219375.CM002139_gene509 1.78e-05 48.5 COG0286@1|root,COG4889@1|root,COG0286@2|Bacteria,COG4889@2|Bacteria,1MWUJ@1224|Proteobacteria,1RRX4@1236|Gammaproteobacteria 1236|Gammaproteobacteria L helicase - - - - - - - - - - - - Helicase_C,Mrr_cat_2,N6_Mtase,ResIII k59_180596_1 1122963.AUHB01000003_gene3983 4.39e-33 124.0 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2U9KB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_153492_2 662755.CRES_0900 2.85e-31 119.0 28J2E@1|root,2Z8YX@2|Bacteria,2IB5J@201174|Actinobacteria,22MJV@1653|Corynebacteriaceae 201174|Actinobacteria S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_233245_4 1144310.PMI07_005836 1.7e-39 143.0 COG4122@1|root,COG4122@2|Bacteria,1N5R0@1224|Proteobacteria,2VETK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_248177_1 227882.SAV_5404 0.000784 45.4 COG1051@1|root,COG1051@2|Bacteria,2IQZT@201174|Actinobacteria 201174|Actinobacteria F Belongs to the NUDIX hydrolase family - - - - - - - - - - - - NUDIX k59_32924_1 691965.D4P7D3_9CAUD 3.3e-83 261.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_395994_1 1040983.AXAE01000008_gene366 4.27e-45 157.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,43M2P@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_209118_1 439235.Dalk_4545 1.1e-12 74.7 2EEYA@1|root,338RP@2|Bacteria,1N7VP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_361195_5 1121378.KB899719_gene424 5.43e-77 278.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1WIA1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,Taq-exonuc k59_221413_2 648250.VNCS_JDNVP 1.91e-166 488.0 4QAUG@10239|Viruses,4QUM5@29258|ssDNA viruses 10239|Viruses L Parvovirus non-structural protein NS1 - GO:0001906,GO:0001907,GO:0005575,GO:0008150,GO:0009889,GO:0010556,GO:0010941,GO:0010942,GO:0016032,GO:0018995,GO:0019048,GO:0019051,GO:0019054,GO:0019056,GO:0019058,GO:0019079,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031341,GO:0031343,GO:0031640,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0035821,GO:0039526,GO:0039592,GO:0039656,GO:0039685,GO:0039693,GO:0042025,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044071,GO:0044215,GO:0044216,GO:0044217,GO:0044364,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0044533,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051726,GO:0051817,GO:0051818,GO:0051883,GO:0052026,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052312,GO:0052330,GO:0052433,GO:0052501,GO:0060139,GO:0060153,GO:0060255,GO:0065007,GO:0080090,GO:2001141 - - - - - - - - - - - k59_128854_1 402777.KB235903_gene1049 3.64e-18 80.1 COG4636@1|root,COG4636@2|Bacteria,1GDI8@1117|Cyanobacteria,1HFGG@1150|Oscillatoriales 1117|Cyanobacteria S Putative restriction endonuclease - - - - - - - - - - - - Uma2 k59_128854_2 1173027.Mic7113_2489 5.35e-27 103.0 COG5499@1|root,COG5499@2|Bacteria,1G8J3@1117|Cyanobacteria,1HCIM@1150|Oscillatoriales 1117|Cyanobacteria K transcription regulator containing HTH domain - - - ko:K18831 - - - - ko00000,ko02048,ko03000 - - - - k59_128854_3 103690.17131334 2.9e-120 363.0 COG1222@1|root,COG1222@2|Bacteria,1G1TR@1117|Cyanobacteria,1HM7E@1161|Nostocales 1117|Cyanobacteria O Holliday junction DNA helicase ruvB N-terminus - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA k59_48843_2 716928.AJQT01000109_gene1216 3.51e-22 103.0 2A70H@1|root,30VVP@2|Bacteria,1NFHJ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_36160_1 1548905.A0A0A1IUL6_9CAUD 5.08e-24 104.0 4QH1V@10239|Viruses,4QPQV@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_236073_1 298386.PBPRB1277 2.56e-15 86.3 COG5281@1|root,COG5281@2|Bacteria,1QUCD@1224|Proteobacteria,1T1T2@1236|Gammaproteobacteria 1236|Gammaproteobacteria D tape measure protein - - - - - - - - - - - - Phage_HK97_TLTM,TMP_2,Tape_meas_lam_C k59_236073_2 1177928.TH2_05218 2.74e-18 84.7 2C095@1|root,32VKM@2|Bacteria,1N0Y9@1224|Proteobacteria,2UJ59@28211|Alphaproteobacteria,2JYQC@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_236073_4 265072.Mfla_2685 1.48e-14 86.3 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2VJEP@28216|Betaproteobacteria 28216|Betaproteobacteria NT Phage-related protein, tail - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_265545_2 666681.M301_2197 1.16e-68 222.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2VK8Q@28216|Betaproteobacteria,2KNH4@206350|Nitrosomonadales 206350|Nitrosomonadales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_277322_1 1005995.GTPT_2564 7.38e-09 58.9 COG2932@1|root,COG2932@2|Bacteria,1N4SP@1224|Proteobacteria,1SYN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Peptidase S24-like - - - - - - - - - - - - HTH_3,Peptidase_S24,Phage_CI_repr k59_291330_1 1218076.BAYB01000030_gene4976 0.000104 51.6 COG3378@1|root,COG3378@2|Bacteria 2|Bacteria KL Phage plasmid primase P4 family - - - ko:K06919 - - - - ko00000 - - - PriCT_2,Prim-Pol,Toprim_4 k59_212902_1 883081.HMPREF9698_01497 5.92e-14 70.9 28J2E@1|root,2Z8YX@2|Bacteria,1TRF9@1239|Firmicutes,4HD03@91061|Bacilli,27H1Z@186828|Carnobacteriaceae 91061|Bacilli S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_157301_1 1168478.I6R9L7_9CAUD 1.55e-25 101.0 4QBFR@10239|Viruses,4QV1E@35237|dsDNA viruses no RNA stage,4QPRX@28883|Caudovirales,4QKMP@10699|Siphoviridae 10699|Siphoviridae S ERF superfamily - - - - - - - - - - - - - k59_265564_1 1540097.A0A0A0YRN0_9CAUD 5.97e-63 213.0 4QF3C@10239|Viruses,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_129104_1 105154.Q9MBU6_9VIRU 5.93e-60 201.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_129104_4 1165094.RINTHH_3920 1.44e-36 135.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_347605_7 748280.NH8B_2279 3.95e-48 170.0 2DZKS@1|root,32VDC@2|Bacteria,1N2FF@1224|Proteobacteria,2VV2V@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_347605_8 1380358.JADJ01000023_gene3898 4.41e-85 269.0 COG4128@1|root,COG4128@2|Bacteria,1REHG@1224|Proteobacteria,1S491@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zonular occludens toxin (Zot) - - - - - - - - - - - - Zot k59_321759_1 1986029.Q9MBM8_9VIRU 5.12e-31 121.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_115732_2 1618251.A0A0C5I2L8_9CIRC 5.94e-07 58.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1077_8 398767.Glov_3115 4.68e-09 69.3 COG0467@1|root,COG3378@1|root,COG0467@2|Bacteria,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,42QNW@68525|delta/epsilon subdivisions,2WMSE@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Phage plasmid primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N k59_338670_1 767434.Fraau_3263 3.46e-23 95.9 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1X61M@135614|Xanthomonadales 135614|Xanthomonadales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_136203_1 546262.NEICINOT_05073 9.04e-21 98.6 COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria 2|Bacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,ParBc k59_311937_2 596153.Alide_1431 6.05e-123 375.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_41772_1 767031.HMPREF9137_2241 1.47e-18 93.6 COG0207@1|root,COG0207@2|Bacteria 2|Bacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis - - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_176423_1 44056.XP_009041542.1 4.2e-14 73.6 2E552@1|root,2SBZD@2759|Eukaryota 44056.XP_009041542.1|- S HNH endonuclease - - - - - - - - - - - - - k59_352165_5 1524467.IV04_14695 1.58e-17 96.7 COG0840@1|root,COG4733@1|root,COG0840@2|Bacteria,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,401CF@613|Serratia 1236|Gammaproteobacteria NT Putative phage tail protein - - - - - - - - - - - - DUF1983,DUF3672,Phage-tail_3 k59_1078_2 765420.OSCT_3100 0.000741 48.9 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,2G854@200795|Chloroflexi 200795|Chloroflexi M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_109024_2 411154.GFO_2923 1.04e-15 76.3 COG0164@1|root,COG0164@2|Bacteria,4NGVR@976|Bacteroidetes,1HWSB@117743|Flavobacteriia 976|Bacteroidetes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_325105_2 767434.Fraau_1461 8.52e-08 54.3 COG1694@1|root,COG1694@2|Bacteria,1N3XF@1224|Proteobacteria,1SSUP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - - k59_95654_2 69328.PVLB_20830 6.47e-09 63.9 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_352425_1 765914.ThisiDRAFT_2636 1.05e-94 283.0 COG2452@1|root,COG2452@2|Bacteria,1P1BA@1224|Proteobacteria,1SSR0@1236|Gammaproteobacteria 1236|Gammaproteobacteria L HTH transcriptional regulator, MerR - - - - - - - - - - - - MerR,Resolvase k59_231385_5 1476390.A0A060RFG0_9CAUD 4.09e-87 285.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_205727_1 136993.KB900626_gene1843 3.83e-07 57.4 COG4725@1|root,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,36XZ4@31993|Methylocystaceae 28211|Alphaproteobacteria KT MT-A70 - - - - - - - - - - - - MT-A70,ParBc k59_57005_1 691965.D4P7I3_9CAUD 3.93e-42 155.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_177984_1 1122201.AUAZ01000017_gene2960 7.1e-126 375.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_138340_1 1075090.GOAMR_58_00660 1.33e-06 55.1 COG1403@1|root,COG1403@2|Bacteria,2GXG1@201174|Actinobacteria,4GFJP@85026|Gordoniaceae 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - HNH k59_340766_1 1122244.AUGF01000092_gene1856 4.58e-08 57.8 2D784@1|root,32TNH@2|Bacteria,1N098@1224|Proteobacteria,1SDM3@1236|Gammaproteobacteria,3NNDQ@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_2759_2 72019.SARC_00068T0 3.43e-42 160.0 2D0VN@1|root,2SFP5@2759|Eukaryota 2759|Eukaryota S REJ domain - - - - - - - - - - - - REJ k59_138342_3 1609634.A0A0C5AFV4_9VIRU 1.08e-63 211.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_272143_2 438753.AZC_0840 3.72e-71 244.0 COG3170@1|root,COG3170@2|Bacteria,1R69E@1224|Proteobacteria,2U3B9@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - - k59_231492_1 1089548.KI783301_gene2629 7.34e-76 242.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_231492_2 1120971.AUCA01000053_gene370 3.05e-83 262.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4HTYH@91061|Bacilli 91061|Bacilli KL DEAD-like helicases superfamily - - - - - - - - - - - - - k59_138608_1 44454.NF84_00635 2.07e-35 122.0 COG4430@1|root,COG4430@2|Bacteria,2IQK3@201174|Actinobacteria,23AQD@1762|Mycobacteriaceae 201174|Actinobacteria S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - DUF1905,OmdA k59_2930_1 1463934.JOCF01000062_gene4346 1.87e-13 75.9 COG1475@1|root,COG1475@2|Bacteria,2IAY7@201174|Actinobacteria 201174|Actinobacteria K Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - ParBc k59_164571_2 526227.Mesil_1223 7.36e-113 332.0 COG4932@1|root,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - CarboxypepD_reg,DUF11,SdrD_B,SprB k59_341095_2 701257.D2XPY9_9CAUD 5.75e-39 140.0 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QKR7@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_327592_1 1341151.ASZU01000008_gene1531 2.77e-59 202.0 COG1783@1|root,COG1783@2|Bacteria,1VK0H@1239|Firmicutes,4HQ2H@91061|Bacilli 91061|Bacilli S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_259282_1 145579.H_BPPHM 6.76e-08 53.9 4QCA6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_259282_2 1385658.U5KPZ6_9VIRU 5.32e-212 605.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_259282_4 1385658.U5KNR1_9VIRU 1.22e-85 267.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_259282_7 145579.H_BPPHM 0.00028 47.0 4QCA6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_327594_1 1609634.A0A0C5AFV4_9VIRU 5.98e-103 317.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_245838_1 243233.MCA2930 3.21e-14 74.7 COG5301@1|root,COG5301@2|Bacteria,1NDIE@1224|Proteobacteria,1SFIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_245838_2 220341.16505384 5.73e-06 51.6 COG5301@1|root,COG5301@2|Bacteria,1MWNN@1224|Proteobacteria,1RR74@1236|Gammaproteobacteria 1236|Gammaproteobacteria M tail collar domain protein - - - - - - - - - - - - Collar,DUF3751,Phage_fiber_2 k59_71603_1 1337093.MBE-LCI_1540 6.58e-17 79.3 COG5614@1|root,COG5614@2|Bacteria,1NC20@1224|Proteobacteria,2UGFP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage head-tail joining protein - - - - - - - - - - - - Phage_H_T_join k59_57259_2 326423.RBAM_032520 7.84e-05 43.9 COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,4HNPJ@91061|Bacilli,1ZJ2S@1386|Bacillus 91061|Bacilli T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_420695_1 1556290.A0A0A0RL96_9CAUD 4.58e-66 228.0 4QGMJ@10239|Viruses,4QSYG@28883|Caudovirales,4QM5B@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_259295_1 909663.KI867149_gene3278 1.49e-18 90.1 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,42THQ@68525|delta/epsilon subdivisions 1224|Proteobacteria D tape measure protein - - - - - - - - - - - - Phage_HK97_TLTM k59_99650_1 656024.FsymDg_3597 3.26e-75 244.0 COG3408@1|root,COG3408@2|Bacteria,2I3UW@201174|Actinobacteria,4EXFQ@85013|Frankiales 201174|Actinobacteria G Glycogen debranching enzyme - - - - - - - - - - - - Glyco_hydro_100,Glyco_hydro_63,Trehalase k59_99650_2 1123236.KB899377_gene37 6.41e-10 58.2 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,466ZE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0234 family yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K09767 - - - - ko00000 - - - DUF520 k59_343624_1 691965.D4P7I3_9CAUD 0.0 1139.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_74242_1 1986029.Q9MBM3_9VIRU 8.65e-66 214.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_74242_3 1385658.U5KPZ6_9VIRU 6.84e-131 393.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_99660_2 344747.PM8797T_01334 8.04e-64 202.0 COG1974@1|root,COG1974@2|Bacteria,2IZCV@203682|Planctomycetes 203682|Planctomycetes K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_4703_1 1332071.L581_2452 1.05e-36 130.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S99W@1236|Gammaproteobacteria,405GZ@613|Serratia 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_59177_1 417280.A1YZY4_9CAUD 9.6e-53 184.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_343634_4 1327977.R9ZXS2_9CAUD 9.96e-46 162.0 4QARC@10239|Viruses,4QV4E@35237|dsDNA viruses no RNA stage,4QPDS@28883|Caudovirales,4QP0H@10744|Podoviridae 10744|Podoviridae S nucleic acid binding - - - - - - - - - - - - - k59_45178_1 90371.CY43_09840 1.5e-15 82.4 2DBI5@1|root,2Z9EN@2|Bacteria,1PMHG@1224|Proteobacteria,1RQE1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Exodeoxyribonuclease VIII - - - ko:K10906 - - - - ko00000,ko01000,ko03400 - - - DUF3799 k59_141676_1 1331060.RLDS_11480 3.99e-22 96.7 COG0175@1|root,COG0175@2|Bacteria,1QZJ1@1224|Proteobacteria,2U233@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_289871_1 511680.BUTYVIB_02299 5.43e-23 104.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,4BWNI@830|Butyrivibrio 186801|Clostridia L Helix-hairpin-helix motif dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_102029_2 1123279.ATUS01000005_gene3105 1.09e-26 106.0 2DNB5@1|root,32WIW@2|Bacteria,1N0BM@1224|Proteobacteria,1S8UT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage HK97-gp10, putative tail-component - - - - - - - - - - - - HK97-gp10_like k59_102029_3 4896.SPAC25B8.10.1 0.000116 49.7 COG0500@1|root,KOG3010@2759|Eukaryota,3A5H4@33154|Opisthokonta,3P1ZJ@4751|Fungi,3QWFM@4890|Ascomycota,3MEF2@451866|Taphrinomycotina 4751|Fungi Q cellular detoxification - GO:0003674,GO:0003824,GO:0005975,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009636,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0044237,GO:0044238,GO:0044262,GO:0046547,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:1990748 - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_102029_5 1231190.NA8A_23404 2.15e-48 164.0 2DKZC@1|root,30ZS6@2|Bacteria,1RGQ9@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_114483_2 1692255.A0A0K1RL52_9CIRC 4.04e-85 265.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_114483_3 1692242.A0A0K1RKZ2_9CIRC 6.58e-27 110.0 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_264261_1 861208.AGROH133_06149 3.93e-25 99.8 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,4B8JK@82115|Rhizobiaceae 28211|Alphaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_264261_2 309801.trd_A0233 1.84e-06 51.2 COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria,2G64H@200795|Chloroflexi,27Y40@189775|Thermomicrobia 189775|Thermomicrobia K Transcriptional Regulator of molybdate metabolism, XRE family - - - - - - - - - - - - HTH_3,PBP_like k59_412219_1 1211115.ALIQ01000023_gene601 1.61e-07 57.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,3NAY7@45404|Beijerinckiaceae 28211|Alphaproteobacteria M Transglycosylase mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_346220_1 172088.AUGA01000071_gene7567 8.67e-32 128.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_155879_1 1541823.A0A088FRU1_9CAUD 2.3e-15 78.6 4QD6Y@10239|Viruses,4QPFN@28883|Caudovirales,4QKM9@10699|Siphoviridae 10699|Siphoviridae S DNA N-6-adenine-methyltransferase (Dam) - - - - - - - - - - - - - k59_397678_2 1408428.JNJP01000030_gene963 8.88e-91 290.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions,2WQN3@28221|Deltaproteobacteria,2M90K@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_220591_1 1123366.TH3_10040 4.39e-15 81.3 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,2JRPG@204441|Rhodospirillales 204441|Rhodospirillales L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_424607_4 345201.EX0N_IIV3 1.66e-118 362.0 4QF69@10239|Viruses,4QV1M@35237|dsDNA viruses no RNA stage 10239|Viruses L XRN 5'-3' exonuclease N-terminus - - - - - - - - - - - - - k59_383355_1 944565.HMPREF9127_0248 5.63e-08 59.3 COG0270@1|root,COG0863@1|root,COG1092@1|root,COG0270@2|Bacteria,COG0863@2|Bacteria,COG1092@2|Bacteria,1TSNX@1239|Firmicutes,2490C@186801|Clostridia,22IR3@1570339|Peptoniphilaceae 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_383355_2 1157490.EL26_01810 3.11e-13 66.6 2E38J@1|root,32Y88@2|Bacteria,1VAXK@1239|Firmicutes,4HNXW@91061|Bacilli,27AM9@186823|Alicyclobacillaceae 91061|Bacilli S VRR_NUC - - - - - - - - - - - - VRR_NUC k59_78146_1 743299.Acife_2622 8.22e-27 118.0 COG1252@1|root,COG2259@1|root,COG1252@2|Bacteria,COG2259@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,2NDMM@225057|Acidithiobacillales 225057|Acidithiobacillales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885,ko:K15977 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - DoxX,Pyr_redox_2 k59_78146_2 99598.Cal7507_0596 6.11e-19 87.0 COG0809@1|root,COG0809@2|Bacteria,1G02D@1117|Cyanobacteria,1HJ1X@1161|Nostocales 1117|Cyanobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_182656_1 935848.JAEN01000011_gene1848 2.36e-25 104.0 COG3409@1|root,COG3409@2|Bacteria,1RAYU@1224|Proteobacteria,2U6D1@28211|Alphaproteobacteria,2PXU7@265|Paracoccus 28211|Alphaproteobacteria M N-acetylmuramidase - - - - - - - - - - - - Muraidase,PG_binding_1 k59_145446_1 290398.Csal_1356 1.2e-10 64.3 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,1RSCD@1236|Gammaproteobacteria,1XPFZ@135619|Oceanospirillales 135619|Oceanospirillales L Arm DNA-binding domain - - - ko:K14059 - - - - ko00000 - - - Arm-DNA-bind_2,Phage_int_SAM_3,Phage_integrase k59_290158_2 1234888.K0A2J2_9VIRU 4.02e-33 127.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_47800_2 1618248.A0A0C5IB82_9CIRC 3.36e-95 290.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_170980_2 469617.FUAG_00742 4.82e-07 50.8 COG0234@1|root,COG0234@2|Bacteria,37AYW@32066|Fusobacteria 32066|Fusobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_278233_2 942016.E9NIH0_9CAUD 1.78e-13 71.2 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_332531_1 1347342.BN863_19390 1.21e-17 88.2 COG3378@1|root,COG3378@2|Bacteria,4NE1A@976|Bacteroidetes,1HY7C@117743|Flavobacteriia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_170986_1 1217656.F964_00542 3.96e-10 62.8 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,1RNR0@1236|Gammaproteobacteria,3NKZI@468|Moraxellaceae 1236|Gammaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_170986_2 382464.ABSI01000005_gene1028 0.000124 46.2 COG0508@1|root,COG0508@2|Bacteria,46SHZ@74201|Verrucomicrobia,2IU2H@203494|Verrucomicrobiae 203494|Verrucomicrobiae C e3 binding domain - - - - - - - - - - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_214891_1 1370120.AUWR01000092_gene2064 2.97e-11 68.9 2EP1Y@1|root,33GNT@2|Bacteria,2IC2I@201174|Actinobacteria,2380S@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_267076_2 107636.JQNK01000009_gene1966 1.38e-26 118.0 2C5MK@1|root,3010G@2|Bacteria,1RA3G@1224|Proteobacteria,2U6GP@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_171477_1 686340.Metal_2595 5.13e-100 296.0 2EKAP@1|root,33E0Y@2|Bacteria,1NAAI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_117014_2 935565.JAEM01000032_gene2600 1.88e-06 57.4 COG4678@1|root,COG4678@2|Bacteria,1N51M@1224|Proteobacteria,2UC8H@28211|Alphaproteobacteria,2PWTF@265|Paracoccus 28211|Alphaproteobacteria G Muramidase (Phage lambda lysozyme) - - - - - - - - - - - - - k59_104622_3 640132.Srot_1187 8.17e-16 77.0 COG1475@1|root,COG1475@2|Bacteria,2HTYC@201174|Actinobacteria 201174|Actinobacteria K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_130757_1 552396.HMPREF0863_01644 9.37e-05 55.8 COG1511@1|root,COG5412@1|root,COG1511@2|Bacteria,COG5412@2|Bacteria,1TRXJ@1239|Firmicutes 1239|Firmicutes S phage tail tape measure protein - - - - - - - - - - - - - k59_50449_1 1692252.A0A0K1RL35_9CIRC 3.34e-27 109.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_363526_3 1218108.KB908297_gene2851 2.68e-08 56.6 COG0726@1|root,COG0726@2|Bacteria,4NR9T@976|Bacteroidetes 976|Bacteroidetes G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_214914_2 1304880.JAGB01000002_gene2222 6.22e-35 144.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1TSMG@1239|Firmicutes,248S7@186801|Clostridia 186801|Clostridia S TIGRFAM Phage - - - - - - - - - - - - Terminase_6,Terminase_6C k59_198556_1 1379720.S5TNF0_9CIRC 1.18e-10 67.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_198556_2 1692244.A0A0K1RLR5_9CIRC 6.36e-16 77.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_40273_1 411459.RUMOBE_03488 8.12e-09 55.1 COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3XZUT@572511|Blautia 186801|Clostridia O Antioxidant, AhpC TSA family bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_238723_1 744980.TRICHSKD4_1012 6.15e-28 128.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_119381_1 257310.BB2209 1.14e-60 199.0 COG0305@1|root,COG0305@2|Bacteria,1PP51@1224|Proteobacteria,2VQ9Z@28216|Betaproteobacteria,3T82N@506|Alcaligenaceae 28216|Betaproteobacteria L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C k59_53518_1 1429767.W6B150_9CAUD 2.99e-45 166.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_53521_1 1379713.S5SYD9_9CIRC 2.98e-10 64.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_375159_2 1007105.PT7_P059 3.04e-25 106.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,3T3DM@506|Alcaligenaceae 28216|Betaproteobacteria S COG4626 Phage terminase-like protein, large subunit - - - - - - - - - - - - Terminase_1 k59_12277_1 717785.HYPMC_1243 2.3e-15 83.6 28MJ5@1|root,2ZAVR@2|Bacteria,1R5CR@1224|Proteobacteria,2UAIJ@28211|Alphaproteobacteria,3N8IV@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Phage_stabilise k59_281579_1 1465751.W8QF08_9VIRU 6.93e-93 289.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage 10239|Viruses S Ribonucleotide reductase, barrel domain - GO:0001959,GO:0001960,GO:0003674,GO:0003824,GO:0004748,GO:0005575,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0010646,GO:0010648,GO:0010803,GO:0010804,GO:0016491,GO:0016725,GO:0016728,GO:0018995,GO:0023051,GO:0023057,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0055114,GO:0060759,GO:0060761,GO:0061731,GO:0065007 - - - - - - - - - - - k59_225222_1 283942.IL0293 2.32e-15 80.5 COG1597@1|root,COG1597@2|Bacteria,1QH8K@1224|Proteobacteria,1RVWU@1236|Gammaproteobacteria,2QGJ7@267893|Idiomarinaceae 1236|Gammaproteobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_174913_1 1380394.JADL01000008_gene3768 3.8e-50 179.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria,2U5NE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - - k59_40315_2 926550.CLDAP_23400 2.35e-16 80.9 2EYH8@1|root,33RR4@2|Bacteria,2G7WE@200795|Chloroflexi 200795|Chloroflexi - - - - - - - - - - - - - - - k59_309941_1 1244856.K4PY94_9CAUD 1.3e-41 161.0 4QHMY@10239|Viruses,4QW88@35237|dsDNA viruses no RNA stage,4QSGS@28883|Caudovirales,4QNFN@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_225230_1 1121441.AUCX01000012_gene3265 4.4e-31 122.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2WM78@28221|Deltaproteobacteria,2M8CT@213115|Desulfovibrionales 28221|Deltaproteobacteria S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_386724_1 1051675.G0YQH7_9CAUD 9.72e-51 177.0 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_402803_2 1423807.BACO01000037_gene1103 6.03e-08 60.1 2DCYU@1|root,32U0J@2|Bacteria,1VC2I@1239|Firmicutes,4IRUY@91061|Bacilli,3FBQ8@33958|Lactobacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_66585_6 36809.MAB_1744 2.91e-58 190.0 COG0629@1|root,COG0629@2|Bacteria,2IR4I@201174|Actinobacteria 201174|Actinobacteria L ERF superfamily - - - - - - - - - - - - ERF k59_202226_1 526218.Sterm_1269 2.24e-13 76.3 COG3941@1|root,COG5185@1|root,COG3941@2|Bacteria,COG5185@2|Bacteria 2|Bacteria D Phage-related minor tail protein - - 3.2.1.18 ko:K01186,ko:K21471,ko:K22051 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko01002,ko01011,ko02000,ko02042 1.A.23.1.2,1.A.23.1.3 GH33 - SLT k59_26830_1 1504672.669782883 4.68e-56 210.0 COG1040@1|root,COG1674@1|root,COG3087@1|root,COG1040@2|Bacteria,COG1674@2|Bacteria,COG3087@2|Bacteria,1QV41@1224|Proteobacteria,2VMZ1@28216|Betaproteobacteria 28216|Betaproteobacteria D ftsk spoiiie - - - - - - - - - - - - - k59_134668_2 1505225.A0A068CBG2_9CAUD 9.16e-16 77.0 4QBHW@10239|Viruses,4QTT7@28883|Caudovirales,4QJZQ@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_239004_1 585503.HMPREF7545_1731 2.13e-12 73.9 COG5323@1|root,COG5323@2|Bacteria,1UMAZ@1239|Firmicutes,4H9ED@909932|Negativicutes 909932|Negativicutes S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_135443_2 278957.ABEA03000008_gene3258 1.3e-11 62.4 2C4D9@1|root,337PW@2|Bacteria,46YN8@74201|Verrucomicrobia,3K9VC@414999|Opitutae 414999|Opitutae S Protein of unknown function (DUF1353) - - - - - - - - - - - - DUF1353 k59_297346_2 1382356.JQMP01000003_gene1536 3.37e-16 79.0 COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi,27XP6@189775|Thermomicrobia 189775|Thermomicrobia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_243388_1 1505227.A0A076GAF9_9CAUD 2.97e-50 162.0 4QGQX@10239|Viruses,4QQ2D@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_324300_1 691965.D4P7D6_9CAUD 1.07e-132 409.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_229743_2 1548905.A0A0A1IVR2_9CAUD 4.12e-13 70.9 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_121902_1 1556290.A0A0A0RM32_9CAUD 9.27e-08 54.3 4QASV@10239|Viruses,4QQ4N@28883|Caudovirales,4QM00@10699|Siphoviridae 10699|Siphoviridae S DNA-dependent ATPase activity - - - - - - - - - - - - - k59_121902_2 999141.GME_04647 1.09e-17 85.1 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1XHV7@135619|Oceanospirillales 135619|Oceanospirillales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_27675_1 1556290.A0A0A0RSX4_9CAUD 5.06e-60 199.0 4QBP9@10239|Viruses,4QPQF@28883|Caudovirales,4QMF3@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF932) - - - - - - - - - - - - - k59_283793_1 7213.XP_004528433.1 5.05e-39 139.0 COG1845@1|root,KOG4664@2759|Eukaryota,39ASV@33154|Opisthokonta,3BF9J@33208|Metazoa,3CUZX@33213|Bilateria,420NY@6656|Arthropoda,3SM4Z@50557|Insecta,44XZ9@7147|Diptera 33208|Metazoa C Subunits I, II and III form the functional core of the enzyme complex COX3 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0008150,GO:0008535,GO:0009987,GO:0016020,GO:0016043,GO:0017004,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045277,GO:0065003,GO:0070069,GO:0070469,GO:0071840,GO:0098796,GO:0098803 - ko:K02262 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX3 k59_337816_2 1609634.A0A0C5AFV4_9VIRU 1.67e-219 624.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_337816_3 105154.Q9MBU3_9VIRU 1.75e-12 71.6 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_337816_8 1609634.A0A0C5AFT2_9VIRU 6.9e-66 212.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_54939_1 999541.bgla_1g10970 0.000215 50.1 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2VJEP@28216|Betaproteobacteria,1KBVU@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage-related protein, tail - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_81575_1 348824.LPU83_2025 3.8e-39 146.0 2A43Y@1|root,30SP0@2|Bacteria,1PBYH@1224|Proteobacteria,2V2BS@28211|Alphaproteobacteria,4BJ13@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_203328_1 1692256.A0A0K1RL85_9CIRC 7.31e-153 436.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_324310_2 582899.Hden_1529 1.93e-30 113.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2UIHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Pathogenesis-related transcriptional factor and ERF protein - - - - - - - - - - - - AP2,HNH_3 k59_162431_1 351016.RAZWK3B_16680 6.48e-17 89.0 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,2UPJH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_81582_1 665950.HMPREF1025_02007 1.04e-27 116.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_162551_1 1200557.JHWV01000001_gene265 2.09e-08 65.1 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4H4XP@909932|Negativicutes 909932|Negativicutes M transglycosylase ltg - - - - - - - - - - - SLT k59_14096_3 296591.Bpro_5358 4.85e-07 58.2 2DBI5@1|root,2Z9EN@2|Bacteria,1PMHG@1224|Proteobacteria,2VWH2@28216|Betaproteobacteria,4AIUK@80864|Comamonadaceae 28216|Betaproteobacteria L PDDEXK-like domain of unknown function (DUF3799) - - - ko:K10906 - - - - ko00000,ko01000,ko03400 - - - DUF3799 k59_83228_1 1085623.GNIT_1810 1.13e-21 92.8 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria 1224|Proteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_298612_1 1423755.BAML01000001_gene75 1.73e-19 102.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,4HATQ@91061|Bacilli,3F44X@33958|Lactobacillaceae 91061|Bacilli L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_298612_3 482537.XP_008566364.1 3.37e-16 79.7 COG3040@1|root,KOG4824@2759|Eukaryota,3A0H1@33154|Opisthokonta,3BPI5@33208|Metazoa,3D6K3@33213|Bilateria,48E28@7711|Chordata,48VI3@7742|Vertebrata,3J6MQ@40674|Mammalia,35AGN@314146|Euarchontoglires 33208|Metazoa M negative regulation of lipoprotein oxidation APOD GO:0000302,GO:0001525,GO:0001568,GO:0001817,GO:0001818,GO:0001944,GO:0001952,GO:0001953,GO:0002682,GO:0002683,GO:0002685,GO:0002686,GO:0003674,GO:0005215,GO:0005319,GO:0005488,GO:0005496,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005829,GO:0005840,GO:0005975,GO:0005996,GO:0006006,GO:0006629,GO:0006810,GO:0006869,GO:0006950,GO:0006979,GO:0007162,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007568,GO:0008150,GO:0008152,GO:0008285,GO:0008289,GO:0009611,GO:0009653,GO:0009888,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010605,GO:0010640,GO:0010642,GO:0010646,GO:0010648,GO:0010810,GO:0010812,GO:0010876,GO:0012505,GO:0014012,GO:0015485,GO:0016043,GO:0019216,GO:0019222,GO:0019318,GO:0022008,GO:0022626,GO:0023051,GO:0023057,GO:0030030,GO:0030154,GO:0030155,GO:0030182,GO:0030334,GO:0030336,GO:0030425,GO:0031099,GO:0031102,GO:0031103,GO:0031175,GO:0031323,GO:0031324,GO:0031347,GO:0031348,GO:0032101,GO:0032102,GO:0032386,GO:0032387,GO:0032501,GO:0032502,GO:0032642,GO:0032682,GO:0032879,GO:0032880,GO:0032934,GO:0032991,GO:0033036,GO:0033157,GO:0033554,GO:0034442,GO:0034443,GO:0035239,GO:0035295,GO:0036094,GO:0036477,GO:0040007,GO:0040012,GO:0040013,GO:0042060,GO:0042127,GO:0042221,GO:0042246,GO:0042306,GO:0042308,GO:0042493,GO:0042995,GO:0043005,GO:0043025,GO:0043178,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044087,GO:0044238,GO:0044281,GO:0044297,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044463,GO:0044464,GO:0045833,GO:0046822,GO:0046823,GO:0048468,GO:0048471,GO:0048513,GO:0048514,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048589,GO:0048646,GO:0048660,GO:0048662,GO:0048666,GO:0048678,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050727,GO:0050728,GO:0050746,GO:0050748,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051179,GO:0051223,GO:0051224,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051248,GO:0051270,GO:0051271,GO:0051716,GO:0051893,GO:0051895,GO:0060255,GO:0060322,GO:0060341,GO:0060587,GO:0060588,GO:0061564,GO:0065007,GO:0070201,GO:0071637,GO:0071638,GO:0071702,GO:0071704,GO:0071840,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0090087,GO:0090109,GO:0090317,GO:0097159,GO:0097447,GO:0097458,GO:0120025,GO:0120036,GO:0120038,GO:1900015,GO:1900016,GO:1900180,GO:1900181,GO:1901700,GO:1901888,GO:1901889,GO:1903391,GO:1903392,GO:1903827,GO:1903828,GO:1904589,GO:1904590,GO:1904950,GO:1990904,GO:2000097,GO:2000098,GO:2000145,GO:2000146,GO:2000401,GO:2000402,GO:2000404,GO:2000405 - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin,Lipocalin_2 k59_298612_4 1305737.JAFX01000001_gene1703 2.46e-08 60.8 COG0438@1|root,COG0438@2|Bacteria,4NWCX@976|Bacteroidetes,47YNM@768503|Cytophagia 976|Bacteroidetes M Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_298612_7 1121382.JQKG01000017_gene1807 9.81e-14 72.4 COG5113@1|root,COG3236@2|Bacteria 2|Bacteria O hydrolase activity, hydrolyzing N-glycosyl compounds ribA GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25 ko:K01497,ko:K09935 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DUF1768,GTP_cyclohydro2 k59_42427_1 1385658.U5KNR1_9VIRU 3.42e-44 156.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_42427_2 1986029.Q9MBM6_9VIRU 3.48e-21 91.3 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_42427_4 105154.Q9MBU6_9VIRU 2.1e-118 357.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_163541_2 1002672.SAR11G3_00103 1.15e-22 100.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria,4BRUC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Polysaccharide biosynthesis protein - - 4.2.1.115 ko:K15894 ko00520,map00520 - R09697 RC02609 ko00000,ko00001,ko01000 - - - Polysacc_synt_2 k59_406760_1 1121360.AUAQ01000003_gene2057 9.17e-26 110.0 COG5412@1|root,COG5412@2|Bacteria,2IH91@201174|Actinobacteria 201174|Actinobacteria E phage tail tape measure protein - - - - - - - - - - - - - k59_190895_2 1540097.A0A0A0YW88_9CAUD 1.09e-163 488.0 4QGA5@10239|Viruses,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_2116_1 107636.JQNK01000008_gene4386 1.46e-90 272.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_406873_1 388739.RSK20926_02032 2.01e-16 84.3 COG0286@1|root,COG4889@1|root,COG0286@2|Bacteria,COG4889@2|Bacteria,1MWUJ@1224|Proteobacteria,2TT41@28211|Alphaproteobacteria 28211|Alphaproteobacteria L InterPro DEAD DEAH box helicase - - - - - - - - - - - - Helicase_C,Mrr_cat_2,N6_Mtase,ResIII k59_70352_3 1538804.A0A088F6T3_9CAUD 2.85e-63 219.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_258433_3 1307761.L21SP2_1407 1.47e-11 69.7 COG1475@1|root,COG1475@2|Bacteria,2J7KN@203691|Spirochaetes 203691|Spirochaetes K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_326442_2 240016.ABIZ01000001_gene5053 1.47e-41 160.0 2DR7Z@1|root,33AM6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_124647_9 547042.BACCOPRO_02637 7.46e-12 72.4 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,2FME3@200643|Bacteroidia,4AM3J@815|Bacteroidaceae 976|Bacteroidetes M Peptidase, M23 - - - - - - - - - - - - Peptidase_M23 k59_246566_1 742740.HMPREF9474_02269 6.69e-07 59.3 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia,222M5@1506553|Lachnoclostridium 186801|Clostridia S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_17030_1 6326.BUX.s00116.953 5.91e-09 68.9 COG5021@1|root,KOG4276@2759|Eukaryota,39M9X@33154|Opisthokonta,3B97M@33208|Metazoa,3CXRM@33213|Bilateria,40B2Z@6231|Nematoda,1KUGJ@119089|Chromadorea 33208|Metazoa O ubiquitin-protein transferase activity HECTD1 GO:0000003,GO:0000209,GO:0001568,GO:0001701,GO:0001775,GO:0001779,GO:0001838,GO:0001841,GO:0001843,GO:0001890,GO:0001892,GO:0001944,GO:0002009,GO:0002376,GO:0002520,GO:0002521,GO:0003006,GO:0003170,GO:0003205,GO:0003231,GO:0003279,GO:0003281,GO:0003674,GO:0003824,GO:0004842,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0007044,GO:0007275,GO:0007399,GO:0007507,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009987,GO:0014020,GO:0016043,GO:0016331,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019941,GO:0021915,GO:0022414,GO:0022607,GO:0030097,GO:0030098,GO:0030101,GO:0030154,GO:0030163,GO:0031581,GO:0032446,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0034329,GO:0034330,GO:0035148,GO:0035239,GO:0035295,GO:0035904,GO:0036211,GO:0043009,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0045321,GO:0046649,GO:0048513,GO:0048519,GO:0048534,GO:0048568,GO:0048598,GO:0048608,GO:0048646,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0051603,GO:0051865,GO:0060341,GO:0060429,GO:0060562,GO:0060606,GO:0060706,GO:0060707,GO:0060708,GO:0060712,GO:0060840,GO:0061458,GO:0061630,GO:0061659,GO:0065007,GO:0070534,GO:0070647,GO:0071704,GO:0071840,GO:0072175,GO:0072358,GO:0072359,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1903076,GO:1903077,GO:1903827,GO:1903828,GO:1904375,GO:1904376,GO:1905475,GO:1905476 2.3.2.26 ko:K12231 - - - - ko00000,ko01000,ko04121 - - - Ank_2,Ank_5,HECT,MIB_HERC2,Sad1_UNC k59_111273_2 1231185.BAMP01000097_gene2372 1.62e-21 98.2 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,43KW8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria KT MT-A70 - - - - - - - - - - - - MT-A70,ParBc k59_165467_1 294631.Q5ZGF6_9CAUD 8.73e-59 197.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_421285_2 1247963.JPHU01000001_gene1923 3.17e-18 82.0 COG0546@1|root,COG0546@2|Bacteria,1RED3@1224|Proteobacteria,2U7YV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S phosphoglycolate phosphatase activity - - - - - - - - - - - - Acid_phosphat_B k59_58137_1 1173028.ANKO01000246_gene4056 1.11e-82 263.0 COG0003@1|root,COG0003@2|Bacteria,1G27T@1117|Cyanobacteria,1H9V1@1150|Oscillatoriales 1117|Cyanobacteria P TIGRFAM arsenite-activated ATPase ArsA - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_408638_1 314282.PCNPT3_12360 1.05e-92 284.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RZEX@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Ribonucleotide reductase beta - - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_31207_1 1073754.G0ZNE5_9VIRU 4.28e-33 123.0 4QAIU@10239|Viruses 10239|Viruses S HNH endonuclease - - - - - - - - - - - - - k59_72702_2 1122201.AUAZ01000017_gene2960 2.74e-179 515.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_152234_2 1268240.ATFI01000008_gene2575 8.69e-14 66.2 2DZP0@1|root,34C5U@2|Bacteria,4P7EP@976|Bacteroidetes,2FV5S@200643|Bacteroidia,4ASNE@815|Bacteroidaceae 976|Bacteroidetes S Domain of unknown function, B. Theta Gene description (DUF3873) - - - - - - - - - - - - DUF3873 k59_355405_1 1385658.U5KNR1_9VIRU 2e-32 125.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_300509_2 1144313.PMI10_00662 5.87e-13 74.3 2C0EQ@1|root,3492A@2|Bacteria,4P5TY@976|Bacteroidetes,1IAIT@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_44094_1 375286.mma_2192 2.49e-24 108.0 2ES6Y@1|root,33JRQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_357954_1 1280692.AUJL01000044_gene2346 1.66e-35 135.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,24DVA@186801|Clostridia,36FNM@31979|Clostridiaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_357954_2 1120971.AUCA01000053_gene371 8.95e-11 61.6 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_396436_1 908340.HMPREF9406_2595 1.08e-33 133.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,24DVA@186801|Clostridia,36FNM@31979|Clostridiaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_75462_1 1227739.Hsw_PB0015 4e-54 186.0 COG1783@1|root,COG1783@2|Bacteria,4NSZ4@976|Bacteroidetes 976|Bacteroidetes S phage Terminase large subunit - - - - - - - - - - - - - k59_154286_1 1033733.CAEK01000007_gene1593 1.11e-29 123.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,22FY9@1570339|Peptoniphilaceae 186801|Clostridia L DNA-directed DNA polymerase dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_329797_1 1692250.A0A0K1RLR1_9CIRC 1.62e-28 112.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_59867_2 1692259.A0A0K1RL59_9CIRC 8.79e-20 88.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_45991_1 1122225.AULQ01000009_gene347 0.000254 49.7 COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,1HZAK@117743|Flavobacteriia 976|Bacteroidetes H cytosine-specific methyltransferase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_288497_1 869724.H6BI57_9CAUD 2.28e-30 121.0 4QBYN@10239|Viruses,4QZT8@35237|dsDNA viruses no RNA stage,4QR5G@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_100644_2 596152.DesU5LDRAFT_3375 4.44e-12 74.7 COG4974@1|root,COG4974@2|Bacteria,1RBMG@1224|Proteobacteria,42R21@68525|delta/epsilon subdivisions,2WN4K@28221|Deltaproteobacteria,2M90A@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase k59_288509_1 754477.Q7C_1438 9.03e-20 89.0 COG0863@1|root,COG0863@2|Bacteria,1R7KV@1224|Proteobacteria,1RZ25@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family VP0394 - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_142859_1 44251.PDUR_17310 6.94e-09 62.0 COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,4HA43@91061|Bacilli,26QCW@186822|Paenibacillaceae 91061|Bacilli M N-acetyl-alpha-D-glucosaminyl L-malate synthase bshA GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_233785_4 1238182.C882_1295 2.73e-37 131.0 COG5113@1|root,COG3236@2|Bacteria,1RCXE@1224|Proteobacteria,2U7XF@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Domain of unknown function (DUF1768) - - - ko:K09935 - - - - ko00000 - - - DUF1768 k59_302452_1 1166018.FAES_3935 9.59e-49 173.0 COG1783@1|root,COG5410@1|root,COG1783@2|Bacteria,COG5410@2|Bacteria,4NN30@976|Bacteroidetes,47YRR@768503|Cytophagia 976|Bacteroidetes S Phage terminase large subunit - - - - - - - - - - - - Terminase_6 k59_46014_1 1235802.C823_01558 1.11e-23 103.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,25V8B@186806|Eubacteriaceae 186801|Clostridia L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_142868_1 545696.HOLDEFILI_01091 6.02e-51 172.0 COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,3VR2J@526524|Erysipelotrichia 526524|Erysipelotrichia M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - VanY k59_358011_1 272560.BPSL1143 4.29e-58 199.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,1K7BW@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_369930_1 1176423.I6RTT8_9VIRU 6.68e-40 145.0 4QCMA@10239|Viruses,4QZ56@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_88010_1 979533.F1D0V0_9CAUD 7.96e-33 127.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_102639_1 1313421.JHBV01000007_gene4258 7.93e-05 52.0 COG1572@1|root,COG3291@1|root,COG1572@2|Bacteria,COG3291@2|Bacteria,4NN8K@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF1735) - - - - - - - - - - - - DUF1735,Laminin_G_3 k59_264899_1 349741.Amuc_1665 6.04e-26 104.0 COG3677@1|root,COG3677@2|Bacteria,46VVN@74201|Verrucomicrobia 74201|Verrucomicrobia L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_264899_2 596153.Alide_4388 1.52e-13 70.1 28N2S@1|root,2ZB8K@2|Bacteria,1R9VY@1224|Proteobacteria,2VRY2@28216|Betaproteobacteria,4AHND@80864|Comamonadaceae 28216|Betaproteobacteria S P63C domain - - - - - - - - - - - - P63C k59_346942_2 1197951.I6RT34_9CAUD 3.27e-107 325.0 4QGAG@10239|Viruses,4R0KB@35237|dsDNA viruses no RNA stage,4QUA4@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_212111_1 1378168.N510_03440 3.52e-60 192.0 COG0863@1|root,COG0863@2|Bacteria,1VRVB@1239|Firmicutes 1239|Firmicutes L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_264907_1 1408452.JAGZ01000014_gene2402 0.000222 46.2 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,234JE@1762|Mycobacteriaceae 201174|Actinobacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_347186_1 349161.Dred_1204 1.32e-26 111.0 COG5511@1|root,COG5511@2|Bacteria,1TQ8B@1239|Firmicutes,24AAT@186801|Clostridia,265XR@186807|Peptococcaceae 186801|Clostridia S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_347186_3 1005995.GTPT_2535 9.15e-38 144.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria,4BVWW@82986|Tatumella 1236|Gammaproteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_371664_1 944480.ATUV01000002_gene375 2.72e-13 79.7 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2M6WB@213113|Desulfurellales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_212401_2 394503.Ccel_1660 5.12e-40 142.0 COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,36FFI@31979|Clostridiaceae 186801|Clostridia O Cytochrome c biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_212408_1 1379722.S5SY31_9CIRC 2.74e-95 287.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_169406_3 1385658.U5KPZ6_9VIRU 1.66e-66 219.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_361078_2 742727.HMPREF9447_04827 1.05e-22 103.0 COG5362@1|root,COG5362@2|Bacteria,4PMSS@976|Bacteroidetes 976|Bacteroidetes S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_347202_1 909297.G8CLB5_9CAUD 4.87e-12 74.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_81182_2 1122621.ATZA01000005_gene539 7.68e-11 63.2 2DMPB@1|root,32SV8@2|Bacteria,4NSG4@976|Bacteroidetes,1ITRF@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_391530_1 1574422.A0A0A1ENW9_9CIRC 3.3e-26 108.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_54519_2 879212.DespoDRAFT_00309 7.27e-12 62.8 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MKYU@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM Cold-shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_27349_1 382640.BT_0527 7.15e-26 108.0 COG3646@1|root,COG3646@2|Bacteria,1N7SM@1224|Proteobacteria,2TY95@28211|Alphaproteobacteria,48UQH@772|Bartonellaceae 28211|Alphaproteobacteria S protein HI1412 of Haemophilus influenzae (P45197) - - - - - - - - - - - - Phage_pRha k59_13810_2 1283336.Q6KGK8_BPFO1 2.98e-28 108.0 4QEBN@10239|Viruses,4R07J@35237|dsDNA viruses no RNA stage,4QT57@28883|Caudovirales,4QK19@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_418334_1 269482.Bcep1808_4543 1.56e-26 107.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2VXCX@28216|Betaproteobacteria,1KA22@119060|Burkholderiaceae 28216|Betaproteobacteria L HNH endonuclease - - - - - - - - - - - - AP2,HNH_3 k59_67880_3 1214065.BAGV01000091_gene340 6.78e-49 170.0 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,1RMNW@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Site-specific DNA-methyltransferase (Adenine-specific) dam GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006281,GO:0006298,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009007,GO:0009008,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0022402,GO:0032259,GO:0032775,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043412,GO:0043414,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044728,GO:0044786,GO:0044787,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:1901681,GO:1902292,GO:1902328,GO:1904047 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_175612_2 1692255.A0A0K1RL52_9CIRC 2.37e-95 291.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_216187_3 520999.PROVALCAL_01907 1.35e-57 195.0 28JXH@1|root,2Z9MZ@2|Bacteria,1MXNC@1224|Proteobacteria,1RNI6@1236|Gammaproteobacteria,3Z9N4@586|Providencia 1236|Gammaproteobacteria S RecT family STY2074 - - - - - - - - - - - RecT k59_405049_1 1304872.JAGC01000005_gene1634 5.69e-11 68.6 COG4675@1|root,COG4675@2|Bacteria,1R14X@1224|Proteobacteria,432A3@68525|delta/epsilon subdivisions,2WXCV@28221|Deltaproteobacteria,2MHGG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_175693_1 1499967.BAYZ01000006_gene5474 2.7e-63 202.0 COG0667@1|root,COG0667@2|Bacteria,2NPI2@2323|unclassified Bacteria 2|Bacteria C Aldo/keto reductase family tas - - - - - - - - - - - Aldo_ket_red k59_311094_1 1122997.AUDD01000007_gene814 2.34e-47 161.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_136797_2 1123366.TH3_19867 8.97e-43 147.0 COG0741@1|root,COG0741@2|Bacteria,1N0U8@1224|Proteobacteria,2UICK@28211|Alphaproteobacteria,2JTZJ@204441|Rhodospirillales 204441|Rhodospirillales M lytic transglycosylase activity - - - - - - - - - - - - - k59_217045_1 7719.XP_009858612.1 6.76e-14 77.4 COG0470@1|root,KOG1970@2759|Eukaryota,39UQ0@33154|Opisthokonta,3BB7E@33208|Metazoa,3D1E3@33213|Bilateria,47Z27@7711|Chordata 33208|Metazoa DL RAD17 checkpoint clamp loader component RAD17 GO:0000075,GO:0000076,GO:0000077,GO:0000228,GO:0000278,GO:0000785,GO:0000790,GO:0003674,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0006139,GO:0006259,GO:0006260,GO:0006275,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0007093,GO:0007346,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010389,GO:0010556,GO:0010558,GO:0010564,GO:0010605,GO:0010948,GO:0010972,GO:0019219,GO:0019220,GO:0019222,GO:0022402,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031570,GO:0031974,GO:0031981,GO:0033314,GO:0033554,GO:0034641,GO:0034645,GO:0042325,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044774,GO:0044818,GO:0045786,GO:0045930,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051174,GO:0051716,GO:0051726,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901576,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902749,GO:1902750,GO:1903047,GO:2000112,GO:2000113 - ko:K06662 ko04111,ko04113,map04111,map04113 - - - ko00000,ko00001,ko03400 - - - Rad17 k59_109398_2 306281.AJLK01000151_gene2010 5.42e-85 275.0 COG0343@1|root,COG0343@2|Bacteria,1GAUU@1117|Cyanobacteria,1JIQU@1189|Stigonemataceae 1117|Cyanobacteria J queuine tRNA-ribosyltransferase activity - - - - - - - - - - - - TGT k59_28793_4 1429767.W6ASK5_9CAUD 2.34e-07 52.0 4QBMV@10239|Viruses,4QUU6@35237|dsDNA viruses no RNA stage,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_176816_1 1123321.KB905821_gene4281 9.81e-24 105.0 COG3291@1|root,COG3291@2|Bacteria,2IHHS@201174|Actinobacteria 201174|Actinobacteria S Pkd domain containing protein - - - - - - - - - - - - - k59_136804_1 1121897.AUGO01000004_gene897 8.65e-06 53.9 COG1215@1|root,COG1215@2|Bacteria,4PKUN@976|Bacteroidetes,1IMP6@117743|Flavobacteriia,2P0TI@237|Flavobacterium 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_190399_2 1434325.AZQN01000010_gene3900 7.51e-24 99.8 COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,47KW3@768503|Cytophagia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_257882_1 1111134.HMPREF1253_1546 8.18e-89 273.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,22GRC@1570339|Peptoniphilaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_392874_1 1410331.W6PEF6_9CAUD 1.01e-13 71.6 4QAM2@10239|Viruses,4QV3W@35237|dsDNA viruses no RNA stage,4QPGK@28883|Caudovirales,4QNW0@10744|Podoviridae 10744|Podoviridae S exonuclease activity - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 - - - - - - - - - - - k59_244716_1 1462526.BN990_03887 6.07e-14 86.3 COG1196@1|root,COG4733@1|root,COG1196@2|Bacteria,COG4733@2|Bacteria,1UIKT@1239|Firmicutes,4ISMQ@91061|Bacilli,4C5ZW@84406|Virgibacillus 91061|Bacilli D cellulase activity - - - - - - - - - - - - - k59_298486_1 1618247.A0A0C5IMK7_9CIRC 1.82e-09 64.3 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_258111_2 761193.Runsl_4894 2.18e-11 61.6 2A95A@1|root,30Y9S@2|Bacteria,4PC8N@976|Bacteroidetes,47WZ1@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_30434_1 68170.KL590470_gene11222 1.04e-107 326.0 COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4DZ2J@85010|Pseudonocardiales 201174|Actinobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_231687_1 764299.STRIC_2135 3.11e-19 81.6 2EC8I@1|root,33670@2|Bacteria,1VENI@1239|Firmicutes,4HR98@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_286218_1 1121033.AUCF01000017_gene3889 9.15e-73 264.0 COG1404@1|root,COG2931@1|root,COG4733@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria,1Q0R4@1224|Proteobacteria,2V8X6@28211|Alphaproteobacteria,2JWZH@204441|Rhodospirillales 204441|Rhodospirillales Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - k59_57513_1 1121422.AUMW01000011_gene161 6.5e-32 125.0 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24I20@186801|Clostridia,26273@186807|Peptococcaceae 186801|Clostridia M PFAM Cysteine-rich secretory protein family - - - - - - - - - - - - CAP,LysM k59_57513_2 1121101.HMPREF1532_02452 1.76e-19 83.2 COG3695@1|root,COG3695@2|Bacteria,4NQ34@976|Bacteroidetes,2FT9F@200643|Bacteroidia,4ARDT@815|Bacteroidaceae 976|Bacteroidetes L 6-O-methylguanine DNA methyltransferase, DNA binding domain ogt - 2.1.1.63 ko:K00567,ko:K07443 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_327853_1 747365.Thena_1527 9.02e-17 73.2 COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,42H2T@68295|Thermoanaerobacterales 186801|Clostridia J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_30826_2 483215.BACFIN_07279 9.45e-10 64.3 COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,2FN75@200643|Bacteroidia,4AK9V@815|Bacteroidaceae 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_286472_1 1027273.GZ77_26340 0.00035 42.7 COG2944@1|root,COG2944@2|Bacteria,1MZGM@1224|Proteobacteria,1SB1E@1236|Gammaproteobacteria,1XPW8@135619|Oceanospirillales 135619|Oceanospirillales K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_315147_2 373994.Riv7116_3856 5.45e-05 50.8 COG0438@1|root,COG4122@1|root,COG0438@2|Bacteria,COG4122@2|Bacteria,1FZUY@1117|Cyanobacteria,1HM22@1161|Nostocales 1117|Cyanobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_2,Glyco_trans_1_4,Glyco_transf_11,Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_21,Methyltransf_23,Methyltransf_24 k59_394403_2 794846.AJQU01000167_gene497 2.6e-23 93.6 2DQIZ@1|root,3376C@2|Bacteria,1N9ZR@1224|Proteobacteria,2UFPZ@28211|Alphaproteobacteria,4BFB9@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_394403_3 1487953.JMKF01000022_gene2495 3.47e-41 150.0 COG3108@1|root,COG3772@1|root,COG3108@2|Bacteria,COG3772@2|Bacteria,1G7YF@1117|Cyanobacteria,1HASB@1150|Oscillatoriales 1117|Cyanobacteria M Phage lysozyme - - - - - - - - - - - - PG_binding_1,Phage_lysozyme k59_16899_20 1094556.MCY_01183 5.19e-17 84.7 COG1044@1|root,COG1044@2|Bacteria,1NBEI@1224|Proteobacteria,2TZFU@28211|Alphaproteobacteria,48URD@772|Bartonellaceae 28211|Alphaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - - - - - - - - - - - k59_365795_1 1157637.KB892113_gene4939 4.15e-05 50.8 COG3469@1|root,COG3469@2|Bacteria,2GJH0@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase 18 family chiA - - - - - - - - - - - CBM_4_9,Glyco_hydro_18,fn3 k59_15064_3 1122201.AUAZ01000017_gene2950 1.82e-21 95.5 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria,46BED@72275|Alteromonadaceae 1236|Gammaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_69547_1 1120956.JHZK01000026_gene786 8.87e-10 62.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,1JNK5@119043|Rhodobiaceae 28211|Alphaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_82837_1 437329.A5A3Q5_9CAUD 1.28e-28 120.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_244572_7 469596.HMPREF9488_03270 2.15e-33 119.0 COG0758@1|root,COG0758@2|Bacteria,1VNFT@1239|Firmicutes 1239|Firmicutes LU Protein of unknown function (DUF2493) - - - - - - - - - - - - DUF2493 k59_258094_2 160488.PP_3881 7.49e-60 201.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RP8Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K terminase - - - - - - - - - - - - Terminase_1 k59_312831_1 861208.AGROH133_06202 1.35e-104 321.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_1742_2 1136417.AZWE01000077_gene278 7.1e-13 73.6 COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4DG5V@85008|Micromonosporales 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_419696_1 932213.SPM24T3_23677 2.81e-117 355.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RP8Z@1236|Gammaproteobacteria,402XD@613|Serratia 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_1744_1 1122997.AUDD01000007_gene814 1.21e-121 358.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_163373_1 449447.MAE_44500 3.78e-54 181.0 COG0675@1|root,COG0675@2|Bacteria,1G0J6@1117|Cyanobacteria 1117|Cyanobacteria L Transposase - - - - - - - - - - - - OrfB_IS605,OrfB_Zn_ribbon k59_72388_1 1437608.BBIA_0637 9.95e-15 73.6 COG4570@1|root,COG4570@2|Bacteria,2GQT6@201174|Actinobacteria,4D1DZ@85004|Bifidobacteriales 201174|Actinobacteria L Endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_72388_4 297246.lpp2117 1.09e-120 374.0 COG0305@1|root,COG0305@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria,1JDPV@118969|Legionellales 118969|Legionellales L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,Toprim_2 k59_341819_1 877421.AUJT01000039_gene3552 5.95e-11 70.1 COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,24818@186801|Clostridia,27J67@186928|unclassified Lachnospiraceae 186801|Clostridia M GDP-mannose 4,6 dehydratase - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_124576_1 207656.S6ATJ4_9CAUD 1.9e-16 88.6 4QAXX@10239|Viruses,4QPTB@28883|Caudovirales,4QHV2@10662|Myoviridae 10662|Myoviridae S Phage terminase large subunit (GpA) - - - - - - - - - - - - - k59_72398_2 428125.CLOLEP_01405 9.15e-31 114.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia,3WNH7@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_72398_3 691965.D4P7B9_9CAUD 1.37e-12 66.2 4QFDH@10239|Viruses,4QWV5@35237|dsDNA viruses no RNA stage,4QPB8@28883|Caudovirales,4QKNN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_380578_1 1545915.JROG01000008_gene3461 7.21e-31 129.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2K0RQ@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_380578_5 309807.SRU_1868 2.1e-27 127.0 COG0419@1|root,COG0419@2|Bacteria,4NH9H@976|Bacteroidetes,1FIK4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_394432_2 471874.PROSTU_04463 8.48e-42 147.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,1RZZ3@1236|Gammaproteobacteria,3Z9YU@586|Providencia 1236|Gammaproteobacteria L RecT family recT GO:0000724,GO:0000725,GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0018130,GO:0019438,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043150,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_16923_1 438753.AZC_3598 8.47e-64 222.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT52@1224|Proteobacteria,2TVNI@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - DnaB_C,Toprim_2 k59_286499_2 762983.HMPREF9444_01702 2.43e-07 55.1 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,1Y3IB@135624|Aeromonadales 135624|Aeromonadales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_206859_3 1411123.JQNH01000001_gene1801 0.000276 44.7 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage terminase-like protein large subunit - - - - - - - - - - - - Terminase_1 k59_329372_1 391600.ABRU01000023_gene781 3.28e-46 152.0 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,2UDAG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S D-alanyl-D-alanine carboxypeptidase - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_287874_1 155515.JP36_07485 1.79e-21 94.7 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1TKGR@1236|Gammaproteobacteria,1Y7SY@135625|Pasteurellales 135625|Pasteurellales S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_153529_1 1609634.A0A0C5AFT2_9VIRU 1.52e-31 122.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_317363_2 156889.Mmc1_1716 3.36e-33 127.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_141852_1 351160.RCIX2617 6.39e-16 79.3 COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,2NAWJ@224756|Methanomicrobia 224756|Methanomicrobia L to Modification methylase in Methanococcus jannaschii (Q58392) and Methanobacterium thermoformicicum (P29568) - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_141852_4 1123269.NX02_21250 3.08e-15 79.3 COG1475@1|root,COG1475@2|Bacteria,1N9EP@1224|Proteobacteria,2UM9Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA binding - - - - - - - - - - - - HTH_23 k59_5029_3 706587.Desti_2197 1.15e-12 73.9 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,42WFA@68525|delta/epsilon subdivisions,2X5AZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pfam:Gp37_Gp68 - - - - - - - - - - - - DUF5131 k59_317646_2 1207076.ALAT01000105_gene1945 8.59e-111 329.0 COG0270@1|root,COG0270@2|Bacteria,1NPQG@1224|Proteobacteria,1S07Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_87174_2 1327036.R4JHP8_9CAUD 1.49e-10 68.6 4QCEF@10239|Viruses,4QVWZ@35237|dsDNA viruses no RNA stage,4QTBA@28883|Caudovirales,4QMGR@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_381870_3 1288494.EBAPG3_1550 1.74e-08 61.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,372DJ@32003|Nitrosomonadales 28216|Betaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_9,Response_reg k59_344045_1 1379709.S5TMV0_9CIRC 3.81e-86 266.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_369324_1 395961.Cyan7425_3706 1.05e-26 108.0 COG0338@1|root,COG0338@2|Bacteria,1G2H8@1117|Cyanobacteria,3KHAX@43988|Cyanothece 1117|Cyanobacteria H D12 class N6 adenine-specific DNA methyltransferase dmnB - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_167106_1 742740.HMPREF9474_02269 7.42e-27 120.0 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia,222M5@1506553|Lachnoclostridium 186801|Clostridia S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_167106_2 665956.HMPREF1032_00674 1.15e-103 321.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,3WNJZ@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_167106_7 941824.TCEL_00063 5.59e-06 48.1 2EUFA@1|root,33MXK@2|Bacteria,1VQFP@1239|Firmicutes,24S0X@186801|Clostridia,36N6B@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_167106_9 691965.D4P7C5_9CAUD 4.89e-139 412.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_180874_1 1121353.H924_07255 1.91e-44 164.0 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,22MAR@1653|Corynebacteriaceae 201174|Actinobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_330944_1 1276756.AUEX01000020_gene3393 1.19e-10 68.9 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,4AATV@80864|Comamonadaceae 28216|Betaproteobacteria S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_220778_4 716541.ECL_03364 3.63e-33 129.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_2 k59_250232_2 325777.GW15_0219580 1.64e-05 54.3 COG2946@1|root,COG2946@2|Bacteria,1RDKM@1224|Proteobacteria,1S46D@1236|Gammaproteobacteria,1X81Y@135614|Xanthomonadales 135614|Xanthomonadales L Replication initiation factor - - - - - - - - - - - - Rep_trans k59_250232_4 926560.KE387023_gene1189 1.67e-09 62.4 COG4675@1|root,COG4675@2|Bacteria,1WMPE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_360252_1 1468411.X2KP98_9CAUD 3.97e-41 153.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_424603_1 153721.MYP_329 5.73e-62 203.0 COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,47P2J@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 57 family amyA - 3.2.1.1 ko:K07405 ko00500,ko01100,map00500,map01100 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH57 - Glyco_hydro_57 k59_346504_1 1122217.KB899582_gene1559 1.13e-39 145.0 2CC4J@1|root,2Z7W8@2|Bacteria,1UX5W@1239|Firmicutes,4H2HV@909932|Negativicutes 909932|Negativicutes S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_7238_1 439235.Dalk_4550 2.57e-11 72.0 COG3055@1|root,COG3209@1|root,COG3055@2|Bacteria,COG3209@2|Bacteria,1NK1N@1224|Proteobacteria 1224|Proteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - Laminin_G_3 k59_360269_1 1121286.AUMT01000001_gene29 1.3e-42 151.0 2C7AW@1|root,32WDQ@2|Bacteria,4NSS0@976|Bacteroidetes,1I4J8@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_89747_6 580327.Tthe_1894 1.45e-21 99.4 COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,42G63@68295|Thermoanaerobacterales 186801|Clostridia H PFAM D12 class N6 adenine-specific DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_250248_1 883081.HMPREF9698_01502 7.54e-30 124.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli,27FFC@186828|Carnobacteriaceae 91061|Bacilli L DNA polymerase family A polA_2 - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_35100_2 751944.HALDL1_01430 7.11e-13 69.3 arCOG06174@1|root,arCOG06174@2157|Archaea,2XTF2@28890|Euryarchaeota,23UDI@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - k59_47781_2 1105384.G8E3X7_9CIRC 5.5e-21 95.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_371139_1 1415780.JPOG01000001_gene1751 1.47e-19 92.8 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,1S4X6@1236|Gammaproteobacteria,1X9SN@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_78140_1 472175.EL18_01361 3.04e-37 142.0 COG5283@1|root,COG5283@2|Bacteria,1QZAD@1224|Proteobacteria,2TY91@28211|Alphaproteobacteria,43PRM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S tape measure - - - - - - - - - - - - PhageMin_Tail k59_78140_5 89187.ISM_12800 8.21e-18 80.9 2CC9N@1|root,3318J@2|Bacteria,1NEWC@1224|Proteobacteria,2UZGP@28211|Alphaproteobacteria,46RZN@74030|Roseovarius 28211|Alphaproteobacteria S Protein of unknown function (DUF3168) - - - - - - - - - - - - DUF3168 k59_145432_1 688245.CtCNB1_2656 7.66e-37 154.0 COG0503@1|root,COG0827@1|root,COG3087@1|root,COG0503@2|Bacteria,COG0827@2|Bacteria,COG3087@2|Bacteria,1QZ6D@1224|Proteobacteria,2WI2K@28216|Betaproteobacteria,4AK49@80864|Comamonadaceae 28216|Betaproteobacteria DFL Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_276398_1 1173762.S4TP28_9CAUD 4.85e-81 265.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_362996_1 926564.KI911740_gene3397 1.21e-90 293.0 COG4626@1|root,COG4626@2|Bacteria,2IP7D@201174|Actinobacteria 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_323145_1 1096546.WYO_0193 7.13e-15 74.3 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria 1224|Proteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_9323_2 1082931.KKY_773 7e-12 69.3 28JTG@1|root,2Z7PY@2|Bacteria,1QVNY@1224|Proteobacteria,2TXVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_266711_1 1472912.A0A023NGU4_9CAUD 1.88e-16 89.7 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0039638,GO:0044403,GO:0044406,GO:0044419,GO:0044423,GO:0044650,GO:0051704,GO:0098015,GO:0098024 - - - - - - - - - - - k59_130234_5 2003327.CAPSD_BPCHP 8.41e-29 124.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_175034_5 1449080.JQMV01000003_gene1740 6.34e-63 215.0 COG0305@1|root,COG0305@2|Bacteria,1WIM7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_187416_1 1692252.A0A0K1RL35_9CIRC 6.38e-37 142.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_134358_1 1185766.DL1_04180 1.33e-34 129.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,2XMXT@285107|Thioclava 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_201964_1 1122201.AUAZ01000026_gene1209 1.11e-69 224.0 2C6N9@1|root,32RHI@2|Bacteria,1P488@1224|Proteobacteria,1SUTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_402626_1 1501230.ET33_36005 9.51e-30 121.0 COG2273@1|root,COG2273@2|Bacteria 2|Bacteria G xyloglucan:xyloglucosyl transferase activity - - - - - - - - - - - - BTAD,Glyco_hydro_16,Glyco_transf_25,Malectin,Ricin_B_lectin,Trans_reg_C,Trypsin,VCBS k59_417599_1 118168.MC7420_7745 1.91e-06 55.1 COG1372@1|root,COG1372@2|Bacteria,1GHBF@1117|Cyanobacteria,1H9VG@1150|Oscillatoriales 1117|Cyanobacteria L Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent - - 1.17.4.1 ko:K00524 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000 - - - Hom_end,Intein_splicing,LAGLIDADG_3 k59_310090_1 1548905.A0A0A1IVR2_9CAUD 4.29e-39 145.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_175067_5 314262.MED193_18919 7.04e-11 68.9 COG4675@1|root,COG4675@2|Bacteria,1RDJW@1224|Proteobacteria,2U3GQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S tail collar domain protein - - - - - - - - - - - - PTR k59_53771_1 1286093.C266_04619 3.07e-113 343.0 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,2VKVD@28216|Betaproteobacteria,1K5XV@119060|Burkholderiaceae 28216|Betaproteobacteria S COG4386 Mu-like prophage tail sheath protein gpL - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k59_402631_1 448385.sce6228 8.36e-11 67.4 COG0265@1|root,COG0265@2|Bacteria,1RHEF@1224|Proteobacteria 1224|Proteobacteria O Trypsin - - - - - - - - - - - - Trypsin_2 k59_255029_2 305700.B447_10653 1.58e-23 94.7 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_66355_1 1229276.DI53_1323 1.06e-39 138.0 COG0720@1|root,COG0720@2|Bacteria,4NM8H@976|Bacteroidetes 976|Bacteroidetes H 6-pyruvoyl tetrahydropterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_121608_6 1237149.C900_02841 0.000714 43.9 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_121608_10 391625.PPSIR1_21429 5.96e-27 116.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42QZQ@68525|delta/epsilon subdivisions,2WMV8@28221|Deltaproteobacteria,2YVB0@29|Myxococcales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase k59_121608_13 1004785.AMBLS11_12290 8.73e-05 53.1 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,1S1E5@1236|Gammaproteobacteria 1236|Gammaproteobacteria D COG4733 Phage-related protein, tail component - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF1983,Phage-tail_3 k59_81135_2 1150626.PHAMO_80087 5.58e-34 150.0 COG3941@1|root,COG3941@2|Bacteria,1PHQP@1224|Proteobacteria,2V9RW@28211|Alphaproteobacteria,2JWSI@204441|Rhodospirillales 204441|Rhodospirillales S Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Tape_meas_lam_C k59_81135_11 1282995.R9W0A5_9CAUD 7.7e-125 368.0 4QFB4@10239|Viruses,4QZ8P@35237|dsDNA viruses no RNA stage,4QSGK@28883|Caudovirales,4QKUP@10699|Siphoviridae 10699|Siphoviridae S viral capsid - - - - - - - - - - - - - k59_81135_12 1300345.LF41_2432 4.79e-08 59.3 2E79U@1|root,331TE@2|Bacteria,1NBV0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_81135_13 1120792.JAFV01000001_gene333 3.3e-43 166.0 28IAN@1|root,2Z8D8@2|Bacteria,1NJD6@1224|Proteobacteria,2U3QV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4055) - - - - - - - - - - - - DUF4055 k59_81135_14 321846.PS417_10075 3.41e-86 277.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1RMTH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_81135_18 500637.PROVRUST_07020 8.98e-10 63.2 COG3091@1|root,COG3091@2|Bacteria,1RJW4@1224|Proteobacteria,1S70F@1236|Gammaproteobacteria,3Z7SD@586|Providencia 1236|Gammaproteobacteria S Belongs to the SprT family sprT - - ko:K02742 - - - - ko00000 - - - SprT-like,Zn_ribbon_SprT k59_81135_25 675806.VII_003790 3.75e-06 55.1 COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,1S2SY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 5'-deoxynucleotidase activity yfdR GO:0002953,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 - ko:K06952 - - - - ko00000 - - - - k59_81135_31 1508644.SFBmNL_00125 3.33e-06 50.1 2EI4V@1|root,33BW7@2|Bacteria,1VKQH@1239|Firmicutes 1239|Firmicutes S Protein of unknwon function (DUF3310) - - - - - - - - - - - - DUF3310 k59_81135_33 417280.A1YZY4_9CAUD 9.67e-49 184.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_81135_41 608538.HTH_0530 2.44e-25 117.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity uvrD3 - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C k59_121616_1 202955.BBND01000008_gene2154 3.53e-08 55.8 COG1403@1|root,COG1403@2|Bacteria,1Q88B@1224|Proteobacteria,1RTRW@1236|Gammaproteobacteria,3NQAV@468|Moraxellaceae 1236|Gammaproteobacteria V HNH endonuclease - - - - - - - - - - - - HNH k59_121616_2 1089121.G8I4T8_9CAUD 4.03e-32 117.0 4QASD@10239|Viruses,4QZ7D@35237|dsDNA viruses no RNA stage,4QTMZ@28883|Caudovirales,4QM9B@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_243077_1 522373.Smlt0654 1.47e-07 60.1 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1X5HN@135614|Xanthomonadales 135614|Xanthomonadales L COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_121745_1 1173762.S4TP25_9CAUD 4.1e-20 90.9 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_418433_1 246199.CUS_7527 1.36e-19 95.1 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,3WGVN@541000|Ruminococcaceae 186801|Clostridia D Peptidase, M23 family - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_94916_2 1450525.JATV01000002_gene2000 1.82e-15 75.5 2DMPB@1|root,32SV8@2|Bacteria,4NSG4@976|Bacteroidetes,1I3FJ@117743|Flavobacteriia,2NW8N@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_310958_2 575540.Isop_2193 1.16e-07 57.0 COG1186@1|root,COG1186@2|Bacteria,2IWU3@203682|Planctomycetes 203682|Planctomycetes J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_82929_6 105154.Q9MBU2_9VIRU 2.34e-22 94.0 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_69707_2 444875.E3SMF7_9CAUD 2.38e-12 79.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_271293_1 1538804.A0A088F6T3_9CAUD 9.88e-88 280.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_204372_1 411460.RUMTOR_01342 4.1e-78 240.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_312742_1 232237.Q7Y5K8_9CAUD 1.54e-15 82.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_419782_2 1121934.AUDX01000016_gene2689 1.84e-20 95.9 COG1475@1|root,COG1475@2|Bacteria,2IAY7@201174|Actinobacteria 201174|Actinobacteria K Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - ParBc k59_150362_16 1121934.AUDX01000003_gene897 2.65e-10 63.2 2CCXQ@1|root,32RWN@2|Bacteria,2IS2D@201174|Actinobacteria 201174|Actinobacteria S Host cell surface-exposed lipoprotein - - - - - - - - - - - - Lipoprotein_Ltp k59_406680_1 1589297.A0A0B5H2N3_9CAUD 1.41e-73 229.0 4QEMD@10239|Viruses,4QUGF@28883|Caudovirales,4QNXF@10744|Podoviridae 10744|Podoviridae S AAA domain - - - - - - - - - - - - - k59_244786_4 871968.DESME_15505 4.12e-25 103.0 COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae 186801|Clostridia F PFAM Cytidine and deoxycytidylate deaminase zinc-binding region comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_244786_6 410359.Pcal_0576 1.46e-15 85.5 COG0270@1|root,arCOG04157@2157|Archaea,2XPTC@28889|Crenarchaeota 28889|Crenarchaeota L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_244786_9 1227739.Hsw_0794 7.34e-25 115.0 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,47JSF@768503|Cytophagia 976|Bacteroidetes E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_354939_1 1439940.BAY1663_00887 0.000664 46.6 COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,1S3DH@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_408507_1 440250.A5HL29_9CAUD 1.52e-18 83.6 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_408507_2 1172188.KB911820_gene2847 4.41e-17 80.9 COG3567@1|root,COG3567@2|Bacteria,2H48H@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_355235_1 69328.PVLB_20830 3.03e-23 104.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_72621_1 484770.UFO1_1695 2.33e-17 86.7 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,4H2HP@909932|Negativicutes 909932|Negativicutes S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_286610_2 1206733.BAGC01000111_gene6957 6.25e-30 126.0 arCOG09463@1|root,2Z8U6@2|Bacteria,2IDM8@201174|Actinobacteria,4G210@85025|Nocardiaceae 201174|Actinobacteria S DNA-sulfur modification-associated dndB - - ko:K19169 - - - - ko00000,ko02048 - - - DndB k59_139674_2 608538.HTH_0747 2.17e-16 79.7 COG0143@1|root,COG0143@2|Bacteria,2G3J0@200783|Aquificae 200783|Aquificae J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_218523_1 1160721.RBI_II00417 1.38e-08 63.2 COG1066@1|root,COG1066@2|Bacteria,1UHUE@1239|Firmicutes,25E2V@186801|Clostridia,3WGAV@541000|Ruminococcaceae 186801|Clostridia O AAA domain - - - - - - - - - - - - AAA_25 k59_124684_1 1609634.A0A0C5AFT2_9VIRU 2.2e-113 337.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_124684_3 186617.M9M8L2_9VIRU 1.26e-15 76.3 4QFNI@10239|Viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_192279_1 1286632.P278_09180 7.15e-58 206.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - CBM_3,Laminin_G_3,Lipase_GDSL_2,fn3 k59_272920_2 305700.B447_04933 3.94e-28 108.0 2EBGC@1|root,335GX@2|Bacteria,1NC6Y@1224|Proteobacteria,2VWRZ@28216|Betaproteobacteria,2KZHU@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_315463_1 1235793.C809_02225 1.3e-114 349.0 COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia 186801|Clostridia S Mu-like prophage protein gp29 - - - - - - - - - - - - - k59_367917_2 1500386.A0A060AFL1_9CAUD 1.03e-16 80.1 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_274683_1 438753.AZC_3587 0.00092 47.0 2DUXE@1|root,32UY2@2|Bacteria,1N2YI@1224|Proteobacteria,2UEWK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage T7 capsid assembly protein - - - - - - - - - - - - Phage_T7_Capsid k59_209787_1 1320556.AVBP01000003_gene3986 9.91e-10 66.2 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_5560_3 1122971.BAME01000116_gene6148 6.31e-08 59.3 COG4974@1|root,COG4974@2|Bacteria,4P01T@976|Bacteroidetes,2FNQ0@200643|Bacteroidia,22WIY@171551|Porphyromonadaceae 976|Bacteroidetes L COG NOG11942 non supervised orthologous group - - - - - - - - - - - - Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase k59_87816_1 926549.KI421517_gene1288 5.29e-53 182.0 COG1783@1|root,COG1783@2|Bacteria,4PMA2@976|Bacteroidetes,47RRH@768503|Cytophagia 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_75615_3 537971.HCCG_00038 4.79e-14 70.1 2EKMA@1|root,33EB3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_234174_2 1788447.A0A190WHJ9_9CIRC 1.84e-108 322.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_126662_1 530564.Psta_0658 4.49e-56 195.0 COG5362@1|root,COG5362@2|Bacteria,2J0FK@203682|Planctomycetes 203682|Planctomycetes S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_318672_1 742733.HMPREF9469_05039 2.22e-58 209.0 28JED@1|root,2Z98K@2|Bacteria,1TW1U@1239|Firmicutes,24CFD@186801|Clostridia,2226E@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - GerE k59_88164_2 1121104.AQXH01000001_gene824 2.79e-16 85.9 COG1475@1|root,COG1475@2|Bacteria,4NFZ9@976|Bacteroidetes,1IPCV@117747|Sphingobacteriia 976|Bacteroidetes K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_113633_1 269482.Bcep1808_4514 0.000276 43.9 COG2944@1|root,COG2944@2|Bacteria,1N75U@1224|Proteobacteria,2VUMV@28216|Betaproteobacteria,1KDD2@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_3 k59_90363_1 1385658.U5KPZ6_9VIRU 5.73e-47 168.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_321258_1 673832.D2IYU1_9CAUD 2.69e-15 72.8 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QKM5@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding - - - - - - - - - - - - - k59_7883_5 880073.Calab_1470 1.1e-48 164.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_305128_1 634177.GLX_21440 7.95e-43 165.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria 1224|Proteobacteria S portal protein beeE - - - - - - - - - - - Phage_portal k59_305128_2 1147149.K7PHP5_9CAUD 1.7e-46 170.0 4QBNM@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPUI@28883|Caudovirales,4QKV6@10699|Siphoviridae 10699|Siphoviridae S Clp protease - - - - - - - - - - - - - k59_305128_3 1121448.DGI_2053 3.74e-169 491.0 COG4653@1|root,COG4653@2|Bacteria,1MXMN@1224|Proteobacteria,42UKA@68525|delta/epsilon subdivisions,2WQZV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_305128_6 1217658.F987_03916 6.2e-09 62.4 COG1442@1|root,COG1442@2|Bacteria,1NJ1J@1224|Proteobacteria,1S14E@1236|Gammaproteobacteria,3NJRC@468|Moraxellaceae 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - Glyco_transf_8 k59_305128_9 999419.HMPREF1077_01409 6.49e-12 69.3 COG0438@1|root,COG0438@2|Bacteria,4PMDN@976|Bacteroidetes 976|Bacteroidetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_196407_1 1121100.JCM6294_535 2.58e-16 81.3 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,2FRI5@200643|Bacteroidia,4ATW7@815|Bacteroidaceae 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_331508_6 1150626.PHAMO_490017 1.58e-27 121.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,2JTE5@204441|Rhodospirillales 204441|Rhodospirillales S Phage portal protein - - - - - - - - - - - - Phage_portal k59_347581_2 796940.HMPREF9628_01619 3.45e-23 100.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,25QH2@186804|Peptostreptococcaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_221587_1 1408433.JHXV01000014_gene3638 6.49e-09 63.5 COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,4NHY5@976|Bacteroidetes,1HZI3@117743|Flavobacteriia 976|Bacteroidetes JM Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N,fn3 k59_347591_1 309801.trd_0738 9.15e-41 153.0 COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi,27XEX@189775|Thermomicrobia 189775|Thermomicrobia L Bacterial DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_8224_1 691965.D4P7E6_9CAUD 4.1e-23 113.0 4QAK6@10239|Viruses,4R01K@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_90743_1 521011.Mpal_0809 3.5e-06 55.5 COG3420@1|root,arCOG03441@1|root,arCOG03500@1|root,arCOG02519@2157|Archaea,arCOG03441@2157|Archaea,arCOG03500@2157|Archaea 2157|Archaea P Disaggregatase related - - - - - - - - - - - - Beta_helix,CarboxypepD_reg,DUF11,Disaggr_assoc,NosD,Pectate_lyase_3,Peptidase_S8 k59_321712_1 1499967.BAYZ01000123_gene2545 1.78e-21 89.4 COG0756@1|root,COG0756@2|Bacteria,2NPXR@2323|unclassified Bacteria 2|Bacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 - - iIT341.HP0865 dUTPase k59_223105_1 484770.UFO1_1695 3.38e-17 85.9 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,4H2HP@909932|Negativicutes 909932|Negativicutes S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_415145_2 1300345.LF41_2410 1.1e-35 128.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria 1224|Proteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_252815_1 1347393.HG726026_gene2622 4.59e-23 107.0 COG3941@1|root,COG3941@2|Bacteria,4NPQ5@976|Bacteroidetes,2FRTG@200643|Bacteroidia,4ASHV@815|Bacteroidaceae 976|Bacteroidetes S tape measure - - - - - - - - - - - - - k59_332999_1 1458669.W6B0U4_9CAUD 3.22e-107 340.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_278904_1 266835.14021428 3.44e-57 208.0 COG2268@1|root,COG2268@2|Bacteria,1NT13@1224|Proteobacteria,2U335@28211|Alphaproteobacteria,43P1F@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Band 7 protein - - - - - - - - - - - - - k59_385333_2 1340829.S5Y5D9_9CAUD 1.55e-48 176.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_373429_2 498761.HM1_2901 0.000379 43.5 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia 186801|Clostridia L snf2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_92437_4 1346330.M472_19260 6.75e-11 63.5 2DMYE@1|root,32UDK@2|Bacteria,4P1A5@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_92437_11 1217710.F969_02564 1.5e-42 160.0 2CHRY@1|root,30Z9E@2|Bacteria,1RGQK@1224|Proteobacteria,1T1AM@1236|Gammaproteobacteria,3NKV5@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - RecT k59_92437_13 1097668.BYI23_E003040 9.8e-29 114.0 2ERP1@1|root,33J8E@2|Bacteria,1R2BU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_117262_2 391598.FBBAL38_06860 1.57e-11 62.4 COG0629@1|root,COG0629@2|Bacteria,4NT9M@976|Bacteroidetes,1I1XK@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF3127) - - - - - - - - - - - - DUF3127 k59_104902_1 1449353.JQMQ01000005_gene4448 1.28e-29 125.0 COG0305@1|root,COG1066@1|root,COG0305@2|Bacteria,COG1066@2|Bacteria,2I8H0@201174|Actinobacteria 201174|Actinobacteria L AAA domain - - - - - - - - - - - - AAA_25,DnaB k59_64065_2 204773.HEAR2284 4.31e-15 82.0 COG1783@1|root,COG1783@2|Bacteria,1MVJB@1224|Proteobacteria,2VKG9@28216|Betaproteobacteria,476G5@75682|Oxalobacteraceae 28216|Betaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_198915_2 760192.Halhy_0174 1.38e-25 103.0 COG0847@1|root,COG0847@2|Bacteria,4NN3T@976|Bacteroidetes,1IRZ2@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Exonuclease, RNase T DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_37979_2 1211817.CCAT010000009_gene816 3.19e-36 134.0 COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,36DMD@31979|Clostridiaceae 186801|Clostridia F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_350118_1 691965.D4P7I3_9CAUD 7.17e-50 179.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_385470_1 759938.F5BSB4_9CIRC 5.23e-27 113.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_429155_2 522373.Smlt3075 6.97e-19 83.6 COG0610@1|root,COG0610@2|Bacteria,1R89U@1224|Proteobacteria,1RZRD@1236|Gammaproteobacteria,1X8I7@135614|Xanthomonadales 135614|Xanthomonadales V Subunit R is required for both nuclease and ATPase activities, but not for modification - - - - - - - - - - - - - k59_402583_2 401053.AciPR4_3094 1.91e-49 169.0 COG0270@1|root,COG0270@2|Bacteria,3Y5V5@57723|Acidobacteria,2JNSG@204432|Acidobacteriia 204432|Acidobacteriia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_429158_2 1396.DJ87_3247 3.56e-06 54.7 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4HB9Q@91061|Bacilli,1ZBKA@1386|Bacillus 91061|Bacilli D peptidase - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_201909_2 1276246.SCULI_v1c04320 2.38e-13 77.8 COG0507@1|root,COG0507@2|Bacteria,3WT5Y@544448|Tenericutes 544448|Tenericutes L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,UvrD_C_2 k59_66283_1 406818.XBJ1_2271 9.25e-06 50.8 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RYET@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - - - - - - - - - - - Peptidase_M19 k59_66283_2 1123053.AUDG01000004_gene3492 8.77e-21 96.7 COG0747@1|root,COG2982@1|root,COG3637@1|root,COG4547@1|root,COG5184@1|root,COG0747@2|Bacteria,COG2982@2|Bacteria,COG3637@2|Bacteria,COG4547@2|Bacteria,COG5184@2|Bacteria,1QVUE@1224|Proteobacteria,1T2J5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M regulator of chromosome condensation, RCC1 - - - - - - - - - - - - OMP_b-brl,fn3 k59_375303_1 608538.HTH_0530 3.11e-12 75.1 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity uvrD3 - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C k59_429161_1 1379709.S5TMV0_9CIRC 4.22e-10 63.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_402591_1 257310.BB3529 0.000601 43.5 2CDBS@1|root,2ZXQ7@2|Bacteria,1P68E@1224|Proteobacteria,2W58M@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_175013_2 1122201.AUAZ01000026_gene1209 6.63e-84 263.0 2C6N9@1|root,32RHI@2|Bacteria,1P488@1224|Proteobacteria,1SUTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_175013_3 1476391.X5KCB6_9CAUD 2.11e-113 363.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_12830_14 1121272.KB903255_gene5774 0.00015 51.2 COG3469@1|root,COG3469@2|Bacteria,2GJH0@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase 18 family - - - - - - - - - - - - CBM_4_9,Glyco_hydro_18,fn3 k59_375696_2 1125863.JAFN01000001_gene3542 4.8e-23 94.0 COG2852@1|root,COG2852@2|Bacteria,1N2UX@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_402839_1 1121271.AUCM01000033_gene2667 9.93e-41 156.0 COG3941@1|root,COG5283@1|root,COG3941@2|Bacteria,COG5283@2|Bacteria,1PRTQ@1224|Proteobacteria,2TRVH@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Potassium ABC transporter ATPase - - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_66660_1 435590.BVU_2836 2.14e-34 137.0 COG1783@1|root,COG1783@2|Bacteria,4NSQV@976|Bacteroidetes,2G22K@200643|Bacteroidia,4AKTX@815|Bacteroidaceae 976|Bacteroidetes S Phage terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_255313_1 411463.EUBVEN_00448 2.22e-15 81.3 COG5511@1|root,COG5511@2|Bacteria,1TQ8B@1239|Firmicutes,24AAT@186801|Clostridia,25Y2T@186806|Eubacteriaceae 186801|Clostridia S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_417925_1 398767.Glov_3217 4.42e-39 143.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2WKMK@28221|Deltaproteobacteria,43TH3@69541|Desulfuromonadales 28221|Deltaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_134748_1 1218084.BBJK01000130_gene7124 1.36e-21 100.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria,1K2NV@119060|Burkholderiaceae 28216|Betaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_375735_1 316407.85676771 2.45e-69 236.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,3XM8P@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_429647_1 349521.HCH_02886 1.93e-33 119.0 COG3023@1|root,COG3023@2|Bacteria,1N032@1224|Proteobacteria,1SFIP@1236|Gammaproteobacteria,1XPM6@135619|Oceanospirillales 135619|Oceanospirillales V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_402875_1 1122991.BAIZ01000025_gene1859 2.94e-26 111.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia 976|Bacteroidetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_66711_1 411902.CLOBOL_02545 7.85e-39 147.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,221Y2@1506553|Lachnoclostridium 186801|Clostridia L COG COG0749 DNA polymerase I - 3-5 exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_134771_1 935866.JAER01000006_gene3401 4.14e-36 139.0 COG4653@1|root,COG4653@2|Bacteria,2ICZP@201174|Actinobacteria 201174|Actinobacteria S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_134772_3 263820.PTO0849 0.000741 43.9 COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,2422T@183967|Thermoplasmata 183967|Thermoplasmata L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules xerA - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_13836_1 1336243.JAEA01000002_gene2639 1e-07 57.4 2ES2P@1|root,33JMP@2|Bacteria,1NGYH@1224|Proteobacteria,2UMK8@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_13836_6 44251.PDUR_05170 3.66e-13 82.0 COG3420@1|root,COG3420@2|Bacteria,1W0T7@1239|Firmicutes,4HYCU@91061|Bacilli,26V7H@186822|Paenibacillaceae 91061|Bacilli P Chondroitinase B - - - - - - - - - - - - Chondroitinas_B,F5_F8_type_C k59_13836_13 273526.SMDB11_2632 1.5e-15 79.3 COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,1S2SY@1236|Gammaproteobacteria,403JZ@613|Serratia 1236|Gammaproteobacteria S 5'-deoxynucleotidase activity yfdR GO:0002953,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 - ko:K06952 - - - - ko00000 - - - - k59_13836_16 935261.JAGL01000009_gene1165 2.03e-228 657.0 COG0209@1|root,COG0209@2|Bacteria,1PM78@1224|Proteobacteria,2UZUM@28211|Alphaproteobacteria,43QGW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - - k59_13836_17 886882.PPSC2_p0514 3.68e-30 117.0 2EN4Y@1|root,30UJG@2|Bacteria,1U1MI@1239|Firmicutes,4IB3Y@91061|Bacilli,273NQ@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_388_4 979525.F1D1L7_9CAUD 7.45e-49 172.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales,4QHWP@10662|Myoviridae 10662|Myoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_388_11 748449.Halha_2259 1.48e-15 78.6 COG4627@1|root,COG4627@2|Bacteria,1UMZF@1239|Firmicutes,24UVP@186801|Clostridia 186801|Clostridia S Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_388_15 395492.Rleg2_3602 5.08e-10 63.5 2D2IW@1|root,32TCX@2|Bacteria,1N4MH@1224|Proteobacteria,2U5DM@28211|Alphaproteobacteria,4BKZQ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1353) - - - - - - - - - - - - DUF1353 k59_388_20 445686.E3SL66_9CAUD 4.41e-168 489.0 4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae 10662|Myoviridae S Major capsid protein Gp23 - GO:0005575,GO:0019012,GO:0019028,GO:0044423 - - - - - - - - - - - k59_388_21 444862.E3SM24_9CAUD 1.35e-39 150.0 4QD5F@10239|Viruses,4QXP5@35237|dsDNA viruses no RNA stage,4QU47@28883|Caudovirales,4QKE0@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_388_22 444862.E3SM23_9CAUD 2.89e-67 213.0 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_388_27 1459636.NTE_02664 5.53e-24 120.0 COG1409@1|root,arCOG06534@1|root,arCOG07781@1|root,arCOG09729@1|root,arCOG06534@2157|Archaea,arCOG07781@2157|Archaea,arCOG09729@2157|Archaea,arCOG11020@2157|Archaea 2157|Archaea S cell adhesion involved in biofilm formation - - - - - - - - - - - - Big_1,CHB_HEX_C_1,He_PIG,PKD,Polysacc_deac_1 k59_388_31 1283076.M1I7U4_9CAUD 8.55e-159 470.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_388_32 1589733.A0A0C5AIT1_9CAUD 3.41e-37 134.0 4QAQQ@10239|Viruses,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_388_35 1283076.M1IP93_9CAUD 8.8e-146 442.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_388_36 445688.E3SNN4_9CAUD 9.38e-143 431.0 4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae 10662|Myoviridae S Terminase-like family - GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949 - - - - - - - - - - - k59_388_40 1340810.V5UT39_9CAUD 6.84e-45 159.0 4QASK@10239|Viruses,4QVVS@35237|dsDNA viruses no RNA stage,4QQFF@28883|Caudovirales,4QIHH@10662|Myoviridae 10662|Myoviridae S Pfam:T4-gp15_tss - GO:0005575,GO:0019012 - - - - - - - - - - - k59_388_43 268746.Q58MN4_BPPRM 1.13e-70 225.0 4QDYQ@10239|Viruses,4QVVQ@35237|dsDNA viruses no RNA stage,4QPVQ@28883|Caudovirales,4QKJF@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_388_53 238854.Q5GQW9_BPSYP 1.54e-63 249.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales 28883|Caudovirales S Pfam:DUF4815 - - - - - - - - - - - - - k59_388_54 444861.E3SPI1_9CAUD 8.38e-21 103.0 4QGRR@10239|Viruses,4QY84@35237|dsDNA viruses no RNA stage,4QR1R@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_388_56 555387.C7BVC0_9CAUD 1.5e-70 246.0 4QHQV@10239|Viruses,4QX6C@35237|dsDNA viruses no RNA stage,4QRJ7@28883|Caudovirales,4QIJU@10662|Myoviridae 10662|Myoviridae S virus tail assembly - - - - - - - - - - - - - k59_388_57 382359.Q0QZC9_BPSYS 7e-20 87.0 4QB1K@10239|Viruses,4QUUK@35237|dsDNA viruses no RNA stage,4QPBK@28883|Caudovirales,4QI9B@10662|Myoviridae 10662|Myoviridae S Gene 25-like lysozyme - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_388_58 224308.BSU21350 1.01e-13 85.1 COG0739@1|root,COG0741@1|root,COG1196@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,COG1196@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1ZH33@1386|Bacillus 91061|Bacilli M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k59_388_64 1283076.M1ICK9_9CAUD 2.21e-18 85.9 4QH5K@10239|Viruses,4QWI8@35237|dsDNA viruses no RNA stage,4QRZM@28883|Caudovirales,4QJPA@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_388_66 445686.E3SKS8_9CAUD 2.83e-52 176.0 4QAX9@10239|Viruses,4QVNY@35237|dsDNA viruses no RNA stage,4QPQH@28883|Caudovirales,4QHWN@10662|Myoviridae 10662|Myoviridae S T4 bacteriophage base plate protein - - - - - - - - - - - - - k59_388_72 1173027.Mic7113_4104 1.57e-18 89.7 COG3409@1|root,COG3772@1|root,COG3409@2|Bacteria,COG3772@2|Bacteria,1G4TY@1117|Cyanobacteria,1HDWU@1150|Oscillatoriales 1117|Cyanobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_388_74 1406779.U5PW83_9CAUD 8.29e-26 115.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_339610_1 756067.MicvaDRAFT_0258 1.55e-63 211.0 COG0003@1|root,COG0003@2|Bacteria,1G27T@1117|Cyanobacteria,1H9V1@1150|Oscillatoriales 1117|Cyanobacteria P TIGRFAM arsenite-activated ATPase ArsA - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_312896_1 937777.Deipe_1570 1.57e-10 65.5 COG0338@1|root,COG0338@2|Bacteria 2|Bacteria L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12,Peptidase_S78_2 k59_150328_1 105154.Q9MBU6_9VIRU 5.89e-113 344.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_419752_1 395019.Bmul_2392 8.58e-09 62.4 COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,1K0AS@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_1802_1 688245.CtCNB1_3554 6.69e-16 80.9 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - Big_2,LRR_5,Laminin_G_3 k59_406598_1 45764.G8I4I0_9CAUD 2.21e-16 77.4 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QKM5@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding - - - - - - - - - - - - - k59_352950_1 1204521.I6ZXZ4_9CAUD 2.42e-12 68.9 4QHBE@10239|Viruses,4QT2W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_352950_2 857087.Metme_0048 1.24e-07 59.3 COG1351@1|root,COG1351@2|Bacteria,1R6TS@1224|Proteobacteria,1S3UM@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_163457_1 1524467.IV04_20585 1.52e-15 76.6 COG4379@1|root,COG4379@2|Bacteria,1MX68@1224|Proteobacteria,1RR6X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tail protein - - - - - - - - - - - - Phage_GPD k59_96277_1 1692242.A0A0K1RL37_9CIRC 9.2e-71 225.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_96277_3 1692248.A0A0K1RLN2_9CIRC 8.27e-31 116.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_339642_1 1230469.M5AAF0_9CAUD 0.000243 47.0 4QGP7@10239|Viruses,4QWWZ@35237|dsDNA viruses no RNA stage,4QQ0Q@28883|Caudovirales,4QMNP@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_137167_1 1391037.T1YRW0_9VIRU 5.11e-82 254.0 4QB6C@10239|Viruses 10239|Viruses L Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_83159_3 278957.ABEA03000120_gene1182 7.75e-12 78.2 COG4733@1|root,COG4733@2|Bacteria,46YHY@74201|Verrucomicrobia,3K9MG@414999|Opitutae 414999|Opitutae S cellulase activity - - - - - - - - - - - - - k59_339650_1 883103.HMPREF9703_00924 5.18e-09 65.1 COG1388@1|root,COG1705@1|root,COG1388@2|Bacteria,COG1705@2|Bacteria,1UYRM@1239|Firmicutes,4HAU6@91061|Bacilli,27FVJ@186828|Carnobacteriaceae 91061|Bacilli MNU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - ko:K02395,ko:K19220,ko:K19223 - - - - ko00000,ko01000,ko01002,ko01011,ko02035 - CBM50 - Glucosaminidase,LysM k59_366229_1 439375.Oant_1499 3.16e-17 80.5 COG3628@1|root,COG3628@2|Bacteria,1N7WS@1224|Proteobacteria,2UFEA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S baseplate assembly protein W - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_300264_2 426117.M446_4075 3.7e-50 174.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2U82T@28211|Alphaproteobacteria,1JXG9@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM RecT protein - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_367805_4 335541.Swol_0227 7.18e-13 70.9 COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia 186801|Clostridia M Polysaccharide biosynthesis protein pseB - 4.2.1.115 ko:K15894 ko00520,map00520 - R09697 RC02609 ko00000,ko00001,ko01000 - - - Polysacc_synt_2 k59_17007_2 1458697.W6EKG4_9CAUD 1.35e-06 58.2 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QM2K@10699|Siphoviridae 10699|Siphoviridae S Phage Tail Collar Domain - - - - - - - - - - - - - k59_98138_1 1235661.K0IP52_9CAUD 3.77e-43 165.0 4QAUF@10239|Viruses,4QWIQ@35237|dsDNA viruses no RNA stage,4QUFS@28883|Caudovirales,4QNVK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_355116_1 1336243.JAEA01000002_gene2664 3.4e-27 115.0 COG5108@1|root,COG5108@2|Bacteria,1PIWB@1224|Proteobacteria,2U1JR@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase - - - - - - - - - - - - RNA_pol,RPOL_N k59_272825_1 105154.Q9MBU3_9VIRU 2.41e-09 58.9 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_272825_2 105154.Q9MBU6_9VIRU 5.41e-31 120.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_17024_1 198214.SF1354 2.79e-13 67.8 2D7I9@1|root,32TP3@2|Bacteria,1N2ZM@1224|Proteobacteria,1S9DB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phage protein - - - - - - - - - - - - DUF1364 k59_165449_4 1458848.X2KRZ1_9CAUD 4.19e-24 103.0 4QBY0@10239|Viruses,4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_408601_1 57477.J9PLM0_9CAUD 4.42e-20 87.8 4QB9C@10239|Viruses,4QWED@35237|dsDNA viruses no RNA stage,4QTNA@28883|Caudovirales,4QJHN@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_179197_1 69279.BG36_03540 2.61e-24 103.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,43K5X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_342184_1 40215.BBOS01000159_gene2032 3.25e-47 157.0 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,1RZSJ@1236|Gammaproteobacteria,3NJ4Z@468|Moraxellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_113023_2 369723.Strop_0517 1.09e-55 184.0 2EES9@1|root,338JX@2|Bacteria,2H5MY@201174|Actinobacteria 201174|Actinobacteria L RNase_H superfamily - - - - - - - - - - - - RNase_H_2 k59_75083_1 1122622.ATWJ01000013_gene40 2.75e-25 108.0 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4FIFZ@85021|Intrasporangiaceae 201174|Actinobacteria M DegT/DnrJ/EryC1/StrS aminotransferase family degT - - - - - - - - - - - DegT_DnrJ_EryC1 k59_209372_1 1248916.ANFY01000003_gene847 1.19e-14 75.1 COG3409@1|root,COG3409@2|Bacteria,1REI1@1224|Proteobacteria,2U734@28211|Alphaproteobacteria,2K4CS@204457|Sphingomonadales 204457|Sphingomonadales M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_410841_1 360911.EAT1b_1551 8.87e-14 78.2 COG4942@1|root,COG4942@2|Bacteria,1VJ3D@1239|Firmicutes,4ITEE@91061|Bacilli 91061|Bacilli D Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_167534_1 264198.Reut_A2381 4.71e-16 72.8 28UBS@1|root,2ZGH5@2|Bacteria,1P4E2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_126267_3 1033743.CAES01000104_gene3490 3.87e-55 217.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HEHJ@91061|Bacilli 91061|Bacilli D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_126267_9 644966.Tmar_0036 3.16e-96 302.0 COG5323@1|root,COG5323@2|Bacteria 2|Bacteria M Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_194216_2 1540097.A0A0A0YW79_9CAUD 4.18e-15 77.4 4QBY0@10239|Viruses,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_344574_2 1114856.C496_00605 3.17e-05 47.4 COG1430@1|root,arCOG03116@2157|Archaea,2XXGG@28890|Euryarchaeota,23VUJ@183963|Halobacteria 183963|Halobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_423027_1 402881.Plav_1318 7.25e-22 94.0 COG4122@1|root,COG4122@2|Bacteria,1QXHD@1224|Proteobacteria,2VF7P@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_145930_1 631454.N177_2363 2.48e-14 73.6 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2TS3X@28211|Alphaproteobacteria,1JPAM@119043|Rhodobiaceae 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_35427_1 1219077.VAZ01S_090_00200 1.25e-73 236.0 COG3969@1|root,COG3969@2|Bacteria,1NBDM@1224|Proteobacteria,1RYRP@1236|Gammaproteobacteria,1XT86@135623|Vibrionales 135623|Vibrionales S Domain of unknown function (DUF3440) - - - - - - - - - - - - DUF3440,PAPS_reduct k59_128330_2 999411.HMPREF1092_01117 3.73e-09 63.9 COG0463@1|root,COG0463@2|Bacteria,1TSF5@1239|Firmicutes,25B5G@186801|Clostridia,36WAT@31979|Clostridiaceae 186801|Clostridia M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,TPR_1,TPR_16,TPR_2,TPR_8 k59_196298_7 1357423.S5M7G5_9CAUD 1.84e-38 143.0 4QBTM@10239|Viruses,4QWCV@35237|dsDNA viruses no RNA stage,4QRTG@28883|Caudovirales,4QIUV@10662|Myoviridae 10662|Myoviridae S methyltransferase activity - - - - - - - - - - - - - k59_90250_1 76869.PputGB1_3399 1.94e-45 155.0 2C2E9@1|root,32RAA@2|Bacteria,1RF5M@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_156744_1 483219.LILAB_18415 4.16e-06 48.5 COG0863@1|root,COG0863@2|Bacteria,1P97D@1224|Proteobacteria,42S8M@68525|delta/epsilon subdivisions,2X85U@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_347120_3 1121413.JMKT01000009_gene2061 4.41e-06 47.0 2ANRP@1|root,31DRG@2|Bacteria,1P58I@1224|Proteobacteria,43265@68525|delta/epsilon subdivisions,2WY9Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_347120_9 457421.CBFG_02928 1.49e-13 71.2 COG2003@1|root,COG2003@2|Bacteria,1V38E@1239|Firmicutes,24M00@186801|Clostridia 186801|Clostridia L DNA repair - - - ko:K03630 - - - - ko00000 - - - RadC k59_212320_2 411476.BACOVA_03902 1.02e-16 79.0 2AA6P@1|root,30ZFR@2|Bacteria,4PDQD@976|Bacteroidetes,2FTPG@200643|Bacteroidia,4ARBQ@815|Bacteroidaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_360993_4 1385658.U5KPZ6_9VIRU 8.56e-198 569.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_276901_2 436114.SYO3AOP1_1290 6.5e-07 53.9 COG2389@1|root,COG2389@2|Bacteria,2G5A9@200783|Aquificae 200783|Aquificae S Uncharacterized metal-binding protein (DUF2227) - - - - - - - - - - - - DUF2227 k59_48402_1 106370.Francci3_0198 4.08e-20 94.0 COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EUUS@85013|Frankiales 201174|Actinobacteria V MacB-like periplasmic core domain yknZ - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_235797_2 172088.AUGA01000033_gene4627 8.93e-09 54.3 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria,3K04T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_415028_1 691965.D4P7I3_9CAUD 2.22e-79 264.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_50646_1 679201.HMPREF9334_00319 4.9e-14 79.3 COG4626@1|root,COG4626@2|Bacteria,1TPU1@1239|Firmicutes,4H6U9@909932|Negativicutes 909932|Negativicutes S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_237177_1 40571.JOEA01000014_gene1609 2.4e-09 63.2 COG2730@1|root,COG2755@1|root,COG5297@1|root,COG2730@2|Bacteria,COG2755@2|Bacteria,COG5297@2|Bacteria,2GKTY@201174|Actinobacteria,4DYMC@85010|Pseudonocardiales 201174|Actinobacteria G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - CBM_10,CBM_2,Cellulase,Lipase_GDSL_2,fn3 k59_293672_1 264731.PRU_1003 6.15e-09 62.8 COG1061@1|root,COG1061@2|Bacteria,4NECV@976|Bacteroidetes,2FNDP@200643|Bacteroidia 976|Bacteroidetes L Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3427,Helicase_C,PLDc_2,ResIII,WG_beta_rep k59_159284_1 585198.HMPREF0574_1041 4.5e-25 112.0 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria,4D4MC@85005|Actinomycetales 201174|Actinobacteria L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_92360_1 882378.RBRH_02935 3.63e-26 102.0 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2VRGU@28216|Betaproteobacteria,1K5ME@119060|Burkholderiaceae 28216|Betaproteobacteria S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_9817_2 713586.KB900537_gene3221 1.11e-18 82.4 COG1192@1|root,COG1192@2|Bacteria,1REZB@1224|Proteobacteria 1224|Proteobacteria D Involved in chromosome partitioning - - - - - - - - - - - - AAA_28 k59_385281_2 1217656.F964_04228 6.37e-30 113.0 COG1917@1|root,COG1917@2|Bacteria,1P4U6@1224|Proteobacteria,1SUV8@1236|Gammaproteobacteria,3NP9A@468|Moraxellaceae 1236|Gammaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_198765_1 1121007.AUML01000036_gene2174 5.76e-19 92.8 COG0613@1|root,COG1409@1|root,COG3325@1|root,COG0613@2|Bacteria,COG1409@2|Bacteria,COG3325@2|Bacteria,4NHY5@976|Bacteroidetes,1HZI3@117743|Flavobacteriia,2YKDZ@290174|Aquimarina 976|Bacteroidetes G Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_223058_1 248742.XP_005642605.1 1.42e-17 82.4 2EN8I@1|root,2SRR6@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - Exostosin k59_159539_1 445970.ALIPUT_01612 2.96e-91 282.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia 976|Bacteroidetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_159539_2 313596.RB2501_01415 2.03e-42 151.0 COG1061@1|root,COG2093@1|root,COG1061@2|Bacteria,COG2093@2|Bacteria,4NECV@976|Bacteroidetes,1HXAD@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF3427) - - - - - - - - - - - - Helicase_C,ResIII k59_417358_1 1524880.A0A076GC88_9VIRU 1.14e-25 110.0 4QAK6@10239|Viruses 10239|Viruses S N-acetylmuramoyl-L-alanine amidase activity - GO:0005575,GO:0019012 - - - - - - - - - - - k59_134109_1 1380355.JNIJ01000017_gene4794 1.06e-22 105.0 COG1475@1|root,COG1475@2|Bacteria,1R31Z@1224|Proteobacteria,2TZWH@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA binding - - - - - - - - - - - - - k59_161689_1 1380393.JHVP01000008_gene4711 4.7e-17 90.1 COG2730@1|root,COG2730@2|Bacteria,2IJWB@201174|Actinobacteria 201174|Actinobacteria G Putative collagen-binding domain of a collagenase - - - - - - - - - - - - Collagen_bind_2,DUF4038 k59_26289_1 1175654.A0A0S0N897_9CAUD 7.63e-50 177.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_26291_1 1406780.U5PZT1_9CAUD 6.37e-16 78.2 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_26291_2 1477404.A0A023NGQ9_9CAUD 1.09e-63 200.0 4QCUB@10239|Viruses,4QYNV@35237|dsDNA viruses no RNA stage,4QRVM@28883|Caudovirales,4QNUK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_134119_1 1122971.BAME01000223_gene6792 4.79e-08 56.6 2DV47@1|root,33TZ6@2|Bacteria,4NT0W@976|Bacteroidetes,2FS1Q@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_175228_1 1192868.CAIU01000008_gene937 5.87e-31 121.0 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria,2UJ12@28211|Alphaproteobacteria,43KMC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_187541_1 391603.FBALC1_09497 1.55e-09 67.8 COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia 976|Bacteroidetes UW surface antigen - - - - - - - - - - - - Peptidase_S74 k59_107280_1 755178.Cyan10605_3498 2.13e-28 114.0 COG0847@1|root,COG0847@2|Bacteria,1GBB5@1117|Cyanobacteria 1117|Cyanobacteria L DNA polymerase III, epsilon - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_175229_3 457415.HMPREF1006_00448 8.49e-16 79.3 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,SNF2_N k59_402731_1 506534.Rhein_2982 2.85e-06 52.4 COG1051@1|root,COG1051@2|Bacteria,1RB8R@1224|Proteobacteria,1S1A6@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_281985_1 195250.CM001776_gene2107 7.09e-28 124.0 COG0507@1|root,COG0507@2|Bacteria,1G8N5@1117|Cyanobacteria,1GZPG@1129|Synechococcus 1117|Cyanobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member - - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_14193_2 1131266.ARWQ01000003_gene1570 2.81e-26 106.0 COG0451@1|root,arCOG04627@2157|Archaea 2157|Archaea GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271,4.2.1.46 ko:K01710,ko:K02377 ko00051,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00051,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00793 R05692,R06513 RC00402,RC01014 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_149228_1 45406.Q06EI0_BPR32 3.39e-10 67.0 4QB5A@10239|Viruses,4QYU7@35237|dsDNA viruses no RNA stage,4QU2H@28883|Caudovirales,4QJ7N@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_55291_1 717773.Thicy_1498 5.29e-10 59.3 COG0286@1|root,COG0286@2|Bacteria,1MWUJ@1224|Proteobacteria,1RRRR@1236|Gammaproteobacteria,4603I@72273|Thiotrichales 72273|Thiotrichales V helicase - - - - - - - - - - - - N6_Mtase k59_55291_2 1461694.ATO9_22830 1.51e-86 262.0 COG0758@1|root,COG0758@2|Bacteria,1R5PU@1224|Proteobacteria,2TTZR@28211|Alphaproteobacteria 28211|Alphaproteobacteria LU DNA recombination-mediator protein A - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_81829_3 31964.CMS0848 1.29e-12 68.2 arCOG05626@1|root,30CNA@2|Bacteria,2I38B@201174|Actinobacteria,4FS6S@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_135728_1 396595.TK90_1231 8.98e-27 112.0 COG3756@1|root,COG3756@2|Bacteria,1QW2K@1224|Proteobacteria,1S1C7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_338162_1 67571.VP50_BPAPS 1.95e-07 57.0 4QBNJ@10239|Viruses,4QWE0@35237|dsDNA viruses no RNA stage,4QQAU@28883|Caudovirales,4QNSD@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF2815) - - - - - - - - - - - - - k59_95239_11 349741.Amuc_1996 7.48e-38 138.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - CHAP,DUF1906,PG_binding_1,Peptidase_M15_4 k59_95239_16 1283299.AUKG01000001_gene2273 5.93e-35 144.0 COG0438@1|root,COG0500@1|root,COG0438@2|Bacteria,COG2226@2|Bacteria,2GUEW@201174|Actinobacteria,4CPRR@84995|Rubrobacteria 84995|Rubrobacteria MQ Methionine biosynthesis protein MetW - - - - - - - - - - - - Glycos_transf_1,Methyltransf_23 k59_393026_1 36651.K9G1H7 5.7e-08 57.8 2D04N@1|root,2SCSW@2759|Eukaryota,3AE35@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - - k59_393026_2 1788443.A0A190WHA2_9CIRC 1.21e-06 56.2 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_123250_1 1548905.A0A0A1IUM0_9CAUD 1.52e-35 128.0 4QE7X@10239|Viruses,4QPUM@28883|Caudovirales,4QMAZ@10699|Siphoviridae 10699|Siphoviridae S Cytidine and deoxycytidylate deaminase zinc-binding region - - - - - - - - - - - - - k59_137426_1 1788455.A0A190WHF5_9CIRC 9.54e-13 73.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_15582_2 1120966.AUBU01000001_gene873 3.19e-22 92.8 COG0110@1|root,COG0110@2|Bacteria,4NUIV@976|Bacteroidetes 976|Bacteroidetes S maltose O-acetyltransferase activity - - - - - - - - - - - - Hexapep k59_379666_5 1165094.RINTHH_3920 6.52e-69 223.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_379666_7 1609634.A0A0C5AFV4_9VIRU 8.28e-90 284.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_258410_1 691965.D4P7I0_9CAUD 1.06e-14 75.1 4QDSZ@10239|Viruses,4QXJ8@35237|dsDNA viruses no RNA stage,4QPKE@28883|Caudovirales,4QM8R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_258410_2 691965.D4P7H8_9CAUD 3.38e-32 118.0 4QG1E@10239|Viruses,4QZE1@35237|dsDNA viruses no RNA stage,4QU6Q@28883|Caudovirales,4QMKH@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_109861_1 1094557.ME3_00584 0.000169 49.3 COG4675@1|root,COG4675@2|Bacteria,1N0FZ@1224|Proteobacteria,2UDXB@28211|Alphaproteobacteria,48T3C@772|Bartonellaceae 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_258415_1 1203611.KB894553_gene2367 3.81e-11 68.9 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,2FNFH@200643|Bacteroidia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_339893_4 1254432.SCE1572_26840 1.99e-19 94.7 COG4675@1|root,COG4675@2|Bacteria,1NFWC@1224|Proteobacteria 1224|Proteobacteria S tail collar domain protein - - - - - - - - - - - - Collar k59_339893_5 264730.PSPPH_2154 2.13e-06 61.2 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,1Z76A@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Domain of unknown function (DUF1983) - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_339893_6 355246.Q333E3_9CAUD 3.09e-06 52.4 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0005575,GO:0018995,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_339893_9 391038.Bphy_3387 0.000441 50.8 COG5283@1|root,COG5283@2|Bacteria,1R5FU@1224|Proteobacteria,2VPNW@28216|Betaproteobacteria,1K6D9@119060|Burkholderiaceae 28216|Betaproteobacteria D tape measure - - - - - - - - - - - - - k59_177273_1 391036.EHF_0203 2.4e-06 55.1 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,47FAN@766|Rickettsiales 766|Rickettsiales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_379670_1 749222.Nitsa_1823 2.58e-26 112.0 COG0270@1|root,COG0270@2|Bacteria,1N0XD@1224|Proteobacteria 1224|Proteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_123268_1 691883.XP_009498267.1 2.8e-11 68.9 COG0740@1|root,KOG0840@2759|Eukaryota,38PE0@33154|Opisthokonta 33154|Opisthokonta O Atp-dependent clp protease proteolytic subunit CLPP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009368,GO:0009987,GO:0010033,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022607,GO:0030163,GO:0031974,GO:0032991,GO:0033554,GO:0034514,GO:0034620,GO:0035966,GO:0035967,GO:0042221,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051259,GO:0051260,GO:0051603,GO:0051716,GO:0065003,GO:0070011,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_285207_1 557598.LHK_01498 2.02e-30 116.0 COG3723@1|root,COG3723@2|Bacteria,1QWBR@1224|Proteobacteria 1224|Proteobacteria L Recombination protein BET bet - - - - - - - - - - - RecT k59_313243_1 313596.RB2501_01311 1.07e-09 67.0 COG1196@1|root,COG1196@2|Bacteria,4NX6E@976|Bacteroidetes 976|Bacteroidetes D nuclear chromosome segregation - - - - - - - - - - - - - k59_109866_2 266265.Bxe_A3055 9.45e-19 87.4 29F88@1|root,3025X@2|Bacteria,1NBJS@1224|Proteobacteria,2VWHK@28216|Betaproteobacteria,1KB80@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_258566_2 1185652.USDA257_c46250 2.66e-32 116.0 2C3WM@1|root,3002C@2|Bacteria,1R3MS@1224|Proteobacteria,2U048@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4326) - - - - - - - - - - - - DUF4326 k59_231084_1 1396141.BATP01000022_gene277 6.11e-30 127.0 COG5525@1|root,COG5525@2|Bacteria,46VZ2@74201|Verrucomicrobia,2IUJ9@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_340105_2 1123020.AUIE01000007_gene3216 4.39e-30 123.0 COG3209@1|root,COG3209@2|Bacteria,1NF2V@1224|Proteobacteria 1224|Proteobacteria M Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_260045_1 5808.XP_002139798.1 0.000192 47.0 COG5275@1|root,KOG1968@2759|Eukaryota,3Y9QU@5794|Apicomplexa,3YJA4@5796|Coccidia 5794|Apicomplexa L Replication factor C subunit - GO:0000278,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K10754 ko03030,ko03420,ko03430,map03030,map03420,map03430 M00289,M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - AAA,BRCT,DNA_pol3_delta,RFC1 k59_139569_1 720554.Clocl_0687 3.26e-05 52.4 COG1403@1|root,COG1403@2|Bacteria,1V178@1239|Firmicutes,24DE2@186801|Clostridia,3WM5B@541000|Ruminococcaceae 186801|Clostridia V HNH endonuclease - - - - - - - - - - - - DUF4373 k59_57940_2 452637.Oter_4251 3.33e-07 57.4 COG2373@1|root,COG2931@1|root,COG3210@1|root,COG4625@1|root,COG5184@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG5184@2|Bacteria,46Z7H@74201|Verrucomicrobia,3K9VS@414999|Opitutae 2|Bacteria DZ regulator of chromosome condensation, RCC1 lapA - - ko:K12549,ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CHU_C,Calx-beta,DUF4347,HemolysinCabind,VWA_2 k59_43874_2 343509.SG1235 7.45e-07 54.3 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - 3.4.21.72 ko:K01347,ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536,ko01000,ko01002,ko02000,ko02044 1.B.12.3 - - CHU_C,F5_F8_type_C,Fil_haemagg_2,Haemagg_act,LRR_5,fn3 k59_341976_1 1539298.JO41_12825 1.5e-46 155.0 2BYEQ@1|root,32SXE@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_300317_1 1414739.W6ATE0_9CAUD 1.38e-53 190.0 4QHNU@10239|Viruses,4QQZH@28883|Caudovirales,4QKRG@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_272875_1 864702.OsccyDRAFT_0687 1.26e-55 184.0 2CWXD@1|root,32T0J@2|Bacteria,1GAQJ@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_206960_2 1207063.P24_02766 7.15e-12 65.1 COG0741@1|root,COG0741@2|Bacteria,1N0U8@1224|Proteobacteria,2UICK@28211|Alphaproteobacteria,2JTZJ@204441|Rhodospirillales 204441|Rhodospirillales M lytic transglycosylase activity - - - - - - - - - - - - - k59_408662_1 1278971.AOGF01000034_gene1750 2.52e-40 148.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,1S4YH@1236|Gammaproteobacteria,1YAWB@135625|Pasteurellales 135625|Pasteurellales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_58167_2 1121028.ARQE01000009_gene4195 5.64e-06 56.2 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2PJDV@255475|Aurantimonadaceae 28211|Alphaproteobacteria K RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_262120_3 1204521.I6ZXZ4_9CAUD 4.05e-07 52.0 4QHBE@10239|Viruses,4QT2W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_112934_1 1515746.HR45_17980 0.000444 44.7 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,2Q9TF@267890|Shewanellaceae 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_74942_1 1131814.JAFO01000001_gene2093 1.24e-30 124.0 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_33048_3 1244856.K4PY83_9CAUD 7.8e-16 76.3 4QE7X@10239|Viruses,4QVF0@35237|dsDNA viruses no RNA stage,4QPUM@28883|Caudovirales,4QP17@10744|Podoviridae 10744|Podoviridae S Cytidine and deoxycytidylate deaminase zinc-binding region - - - - - - - - - - - - - k59_248301_3 1123058.KB894283_gene1542 9.95e-05 51.2 COG3064@1|root,COG5295@1|root,COG3064@2|Bacteria,COG5295@2|Bacteria 2|Bacteria UW Hep Hag repeat protein tek - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - HemolysinCabind,Hint_2,Peptidase_S74 k59_369493_1 1265502.KB905947_gene1051 6.41e-11 66.2 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,4AAHN@80864|Comamonadaceae 28216|Betaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_329718_1 1486472.A0A068F3I8_9CAUD 2.57e-70 231.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_288345_1 1047013.AQSP01000118_gene1252 3.76e-38 143.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - - k59_126130_1 1327981.S0A2H8_9CAUD 7.74e-53 184.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_209436_1 1175654.A0A0S0N897_9CAUD 1.08e-73 240.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_369518_1 1340493.JNIF01000004_gene1160 1.38e-75 244.0 COG0464@1|root,COG0464@2|Bacteria 2|Bacteria O ATPase activity - - - - - - - - - - - - AAA,TniB k59_87443_1 588596.U9TBH4 2.01e-21 95.9 COG1372@1|root,2QRRC@2759|Eukaryota,39SG8@33154|Opisthokonta,3PD1S@4751|Fungi 4751|Fungi L Allomyces macrogynus ATCC 38327 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent - - - - - - - - - - - - - k59_410689_2 1151061.CAJY01000041_gene672 3.82e-19 82.0 2E46I@1|root,332GH@2|Bacteria,2I85D@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_274455_2 105154.Q9MBU0_9VIRU 2.98e-66 215.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_274455_4 1385658.U5KPZ6_9VIRU 2.88e-187 542.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_274455_5 105154.Q9MBU3_9VIRU 7.78e-13 72.8 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_262327_3 1185766.DL1_19620 1.5e-34 129.0 COG3409@1|root,COG3409@2|Bacteria,1RAYU@1224|Proteobacteria,2U6D1@28211|Alphaproteobacteria 28211|Alphaproteobacteria M N-acetylmuramidase - - - - - - - - - - - - Muraidase,PG_binding_1 k59_78398_1 1123226.KB899282_gene3006 7.66e-10 63.2 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,4H9ZU@91061|Bacilli,26UT1@186822|Paenibacillaceae 91061|Bacilli G Fructose-bisphosphate aldolase class-II iolJ - 4.1.2.13,4.1.2.29 ko:K01624,ko:K03339 ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568,R05378 RC00438,RC00439,RC00603,RC00604,RC00721 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU39670 F_bP_aldolase k59_145715_1 1028806.GGE_0920 2.54e-43 161.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RP8Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K terminase - - - - - - - - - - - - Terminase_1 k59_182795_1 665942.HMPREF1022_03278 3.74e-50 178.0 28MSK@1|root,2ZB0X@2|Bacteria,1R7CY@1224|Proteobacteria,42YXC@68525|delta/epsilon subdivisions,2WTJ0@28221|Deltaproteobacteria,2M9DF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_61623_2 936155.HFELIS_00560 1.8e-36 129.0 COG3023@1|root,COG3023@2|Bacteria,1PFYI@1224|Proteobacteria,431SU@68525|delta/epsilon subdivisions 1224|Proteobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_424739_1 1414720.CBYM010000005_gene1357 2.17e-28 116.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_47956_1 345201.VF401_IIV3 1.51e-14 70.1 4QFI2@10239|Viruses,4QX08@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_47956_2 1465751.W8QF75_9VIRU 8.99e-81 252.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage 10239|Viruses S bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity - - - - - - - - - - - - - k59_21423_1 1304878.AUGD01000014_gene3052 4.79e-48 162.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,3JT22@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T transcriptional regulator, winged helix family copR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_169151_2 194966.Q7Y5M4_BPSP6 2.07e-32 117.0 4QB6G@10239|Viruses,4QVYX@35237|dsDNA viruses no RNA stage,4QQS8@28883|Caudovirales,4QNR7@10744|Podoviridae 10744|Podoviridae S Peptidase M15 - - - - - - - - - - - - - k59_346765_1 765698.Mesci_3812 5.61e-06 53.1 2C22H@1|root,30QGC@2|Bacteria,1PKNY@1224|Proteobacteria,2UZAT@28211|Alphaproteobacteria,43PHR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_78405_2 1265503.KB905160_gene2404 6.97e-51 168.0 COG4333@1|root,COG4333@2|Bacteria,1N19M@1224|Proteobacteria,1SAS8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF1643 k59_304564_1 218851.Aquca_010_00131.1 9.56e-58 187.0 COG2036@1|root,KOG1745@2759|Eukaryota,37TVG@33090|Viridiplantae,3GI0A@35493|Streptophyta 35493|Streptophyta B histone H3 - - - ko:K11253 ko05034,ko05202,ko05322,map05034,map05202,map05322 - - - ko00000,ko00001,ko03036,ko04147 - - - Histone k59_331266_1 521045.Kole_0355 3.42e-70 237.0 COG2804@1|root,COG2804@2|Bacteria,2GCDW@200918|Thermotogae 200918|Thermotogae NU PFAM type II secretion system protein E - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_102468_3 1443113.LC20_03522 2.73e-10 58.9 2CIZN@1|root,33BAP@2|Bacteria,1NJHF@1224|Proteobacteria,1SHYB@1236|Gammaproteobacteria,41HCR@629|Yersinia 1236|Gammaproteobacteria S Superinfection immunity protein - - - - - - - - - - - - Imm_superinfect,SHOCT k59_235458_1 1788442.A0A190WH98_9CIRC 4.1e-51 172.0 4QB6C@10239|Viruses,4QUKM@29258|ssDNA viruses 10239|Viruses J Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_128185_2 1108070.G8FUZ0_9CAUD 7.15e-05 50.1 4QC5Z@10239|Viruses,4QUNP@35237|dsDNA viruses no RNA stage,4QPGX@28883|Caudovirales,4QKMB@10699|Siphoviridae 10699|Siphoviridae S Phage Mu protein F like protein - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_383514_1 426117.M446_3879 2.53e-33 126.0 COG0582@1|root,COG0582@2|Bacteria,1R7GV@1224|Proteobacteria,2TT06@28211|Alphaproteobacteria,1JUET@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_320995_1 1385658.U5KPZ6_9VIRU 7.95e-212 604.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_48249_1 683083.C414_000010156 1.53e-07 60.5 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,42T09@68525|delta/epsilon subdivisions,2YPNJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_347018_1 1123072.AUDH01000029_gene1053 3.77e-29 122.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,2TT3N@28211|Alphaproteobacteria,2JQ8P@204441|Rhodospirillales 204441|Rhodospirillales S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_91902_2 489825.LYNGBM3L_40970 0.000187 45.1 2DKXV@1|root,30THP@2|Bacteria,1GQMH@1117|Cyanobacteria 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_278287_4 411460.RUMTOR_01352 3.57e-33 120.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_278287_7 428125.CLOLEP_01409 3.19e-212 604.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_171092_2 1236976.JCM16418_4597 3.11e-16 81.6 2EN4Y@1|root,30UJG@2|Bacteria,1U1MI@1239|Firmicutes,4IB3Y@91061|Bacilli,273NQ@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_306869_1 1589748.A0A0B4ZZW7_9CAUD 6.71e-15 77.8 4QGPT@10239|Viruses,4QQI9@28883|Caudovirales,4QMUP@10699|Siphoviridae 10699|Siphoviridae S DNA catabolic process, endonucleolytic - - - - - - - - - - - - - k59_400088_1 292414.TM1040_1311 2.44e-13 69.7 2EMSQ@1|root,33FF4@2|Bacteria,1RGIN@1224|Proteobacteria,2U8XZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1064) - - - - - - - - - - - - DUF1064 k59_307019_1 1183438.GKIL_3838 1.15e-06 55.8 COG3177@1|root,COG3177@2|Bacteria,1G3Q5@1117|Cyanobacteria 1117|Cyanobacteria K PFAM Fic DOC family - - - - - - - - - - - - DUF4172,Fic,Fic_N k59_426691_2 1140.Synpcc7942_0744 4.48e-08 59.3 28I7K@1|root,2Z7Y6@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4815) - - - - - - - - - - - - - k59_198384_1 1123008.KB905702_gene2353 1.96e-21 96.3 COG1783@1|root,COG1783@2|Bacteria,4NHPB@976|Bacteroidetes,2FR95@200643|Bacteroidia,22WQM@171551|Porphyromonadaceae 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_9536_3 269482.Bcep1808_1171 4.65e-11 68.2 28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,2W6XZ@28216|Betaproteobacteria,1KD72@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_173828_4 329726.AM1_2219 4.68e-22 106.0 COG0507@1|root,COG0507@2|Bacteria,1G4VJ@1117|Cyanobacteria 1117|Cyanobacteria L DNA helicase - - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_428533_1 688245.CtCNB1_3555 6.72e-28 114.0 COG5301@1|root,COG5301@2|Bacteria,1PG83@1224|Proteobacteria,2WBY1@28216|Betaproteobacteria,4AIIK@80864|Comamonadaceae 28216|Betaproteobacteria UW Hep Hag repeat protein - - - - - - - - - - - - - k59_161261_2 1609634.A0A0C5AFT2_9VIRU 1.31e-54 187.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_161261_4 1609634.A0A0C5AFV4_9VIRU 1.62e-201 578.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_106511_1 1082932.ATCR1_04639 3.83e-13 79.0 COG4678@1|root,COG4678@2|Bacteria,1RDU0@1224|Proteobacteria,2U7AC@28211|Alphaproteobacteria,4B7Q3@82115|Rhizobiaceae 28211|Alphaproteobacteria G nuclear chromosome segregation - - - - - - - - - - - - - k59_11565_1 1173028.ANKO01000246_gene4056 7.6e-92 286.0 COG0003@1|root,COG0003@2|Bacteria,1G27T@1117|Cyanobacteria,1H9V1@1150|Oscillatoriales 1117|Cyanobacteria P TIGRFAM arsenite-activated ATPase ArsA - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_25748_1 937777.Deipe_0478 3.14e-24 101.0 28W6R@1|root,2ZI7D@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_296139_2 521097.Coch_0896 3.62e-77 252.0 2DBFR@1|root,2Z8ZR@2|Bacteria,4NG43@976|Bacteroidetes,1HZHP@117743|Flavobacteriia 976|Bacteroidetes S Terminase-like family - - - - - - - - - - - - Terminase_3,Terminase_6 k59_280821_1 5207.AAW44161 1.22e-17 90.9 COG0086@1|root,KOG0261@2759|Eukaryota,38G14@33154|Opisthokonta,3NXKP@4751|Fungi,3UZ6M@5204|Basidiomycota,3VDIB@5234|Tremellales 4751|Fungi H DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates RPO31 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005666,GO:0006139,GO:0006351,GO:0006383,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009304,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042797,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0098781,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03018,ko:K21594 ko00230,ko00240,ko01100,ko03020,ko04623,ko05169,map00230,map00240,map01100,map03020,map04623,map05169 M00181 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03029 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_173870_3 335543.Sfum_0964 1.53e-43 169.0 2DMDG@1|root,32PV1@2|Bacteria,1MXEK@1224|Proteobacteria,42TGJ@68525|delta/epsilon subdivisions,2X7Q0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_296145_1 1477404.A0A023NFX4_9CAUD 4.95e-54 194.0 4QAXA@10239|Viruses,4QYJI@35237|dsDNA viruses no RNA stage,4QQ1A@28883|Caudovirales,4QNU7@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_224567_1 1132836.RCCGE510_12336 8.07e-13 67.4 2FB2D@1|root,34392@2|Bacteria,1N749@1224|Proteobacteria,2UVQ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_254280_2 648996.Theam_0533 0.000604 48.5 COG3291@1|root,COG4870@1|root,COG3291@2|Bacteria,COG4870@2|Bacteria,2G57S@200783|Aquificae 200783|Aquificae O Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD k59_351227_1 176279.SERP2545 0.000115 48.1 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H9Y4@91061|Bacilli,4GY9S@90964|Staphylococcaceae 91061|Bacilli J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_27511_1 977880.RALTA_A2159 2.23e-25 110.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,1K0GR@119060|Burkholderiaceae 28216|Betaproteobacteria M transglycosylase - - - - - - - - - - - - DUF4124,SLT k59_108302_1 1237149.C900_01790 5.06e-05 51.2 COG0729@1|root,COG2911@1|root,COG0729@2|Bacteria,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - - - - - - - - - - Bac_surface_Ag,Haemagg_act,Peptidase_S74 k59_337646_2 942016.E9NID5_9CAUD 5.15e-24 102.0 4QBMV@10239|Viruses,4QUU6@35237|dsDNA viruses no RNA stage,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_216223_1 1692250.A0A0K1RLR1_9CIRC 1.07e-23 103.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_283653_2 1236573.K4LRV6_9CAUD 1.23e-10 71.2 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0016032,GO:0019058,GO:0019068,GO:0044403,GO:0044419,GO:0051704,GO:0098003 - - - - - - - - - - - k59_311105_5 240016.ABIZ01000001_gene4589 4.14e-06 60.8 COG3210@1|root,COG4932@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CarboxypepD_reg,DUF11,DUF4347,LTD,Laminin_G_3,PATR,SdrD_B k59_68027_2 691965.D4P7C0_9CAUD 1.22e-55 177.0 4QDUR@10239|Viruses,4QVMY@35237|dsDNA viruses no RNA stage,4QU8R@28883|Caudovirales,4QKNQ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_68027_4 68219.JNXI01000028_gene3318 2.5e-77 243.0 COG3023@1|root,COG3023@2|Bacteria,2GW67@201174|Actinobacteria 201174|Actinobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_68027_5 742740.HMPREF9474_02274 5.92e-30 113.0 2DHA9@1|root,32U8X@2|Bacteria,1VD44@1239|Firmicutes,24NC3@186801|Clostridia,222SC@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_68027_7 595537.Varpa_2028 1.15e-23 106.0 COG4675@1|root,COG5295@1|root,COG4675@2|Bacteria,COG5295@2|Bacteria,1P3I0@1224|Proteobacteria 1224|Proteobacteria UW Hep Hag repeat protein - - - - - - - - - - - - - k59_68027_9 404380.Gbem_3053 5.71e-07 63.2 COG0689@1|root,COG2982@1|root,COG3209@1|root,COG0689@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria 1224|Proteobacteria M Rhs Family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat k59_68027_10 742740.HMPREF9474_02273 0.000137 48.9 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia,223KD@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_68027_11 691965.D4P7C5_9CAUD 0.0 925.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_68027_12 742733.HMPREF9469_05032 4.23e-156 453.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,221RR@1506553|Lachnoclostridium 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_68027_13 691965.D4P7D6_9CAUD 4.34e-188 557.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_68027_14 411460.RUMTOR_01344 1.02e-32 117.0 2E2Y0@1|root,32XYV@2|Bacteria,1VD9S@1239|Firmicutes,24PK0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_68027_16 411460.RUMTOR_01342 1.12e-86 263.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_68027_17 742733.HMPREF9469_05023 1.12e-54 178.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,222RY@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_190921_1 637910.ROD_26061 1.2e-09 60.8 2CJWY@1|root,30JBW@2|Bacteria,1PG53@1224|Proteobacteria,1TKZ8@1236|Gammaproteobacteria,3WZIN@544|Citrobacter 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_190921_2 932213.SPM24T3_23257 1.8e-28 106.0 COG5614@1|root,COG5614@2|Bacteria,1N9Y5@1224|Proteobacteria,1SE8T@1236|Gammaproteobacteria,405JB@613|Serratia 1236|Gammaproteobacteria S COG5614 Bacteriophage head-tail adaptor - - - - - - - - - - - - Phage_H_T_join k59_190921_3 1439940.BAY1663_02344 1.46e-18 82.0 2EI3E@1|root,33BUW@2|Bacteria,1NGUW@1224|Proteobacteria,1ST4E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage gp6-like head-tail connector protein - - - - - - - - - - - - Phage_connect_1 k59_137556_2 648250.CAPSD_JDNVP 9.9e-11 64.3 4QEBH@10239|Viruses,4QUMC@29258|ssDNA viruses 10239|Viruses S Capsid protein VP4 - - - - - - - - - - - - - k59_177340_1 1618248.A0A0C5IB82_9CIRC 3.99e-89 275.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_191052_1 404380.Gbem_1819 6.61e-14 76.6 COG1572@1|root,COG1621@1|root,COG2706@1|root,COG3209@1|root,COG3291@1|root,COG1572@2|Bacteria,COG1621@2|Bacteria,COG2706@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity scrB GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044464,GO:0046352,GO:0071704,GO:1901575 2.7.1.211,3.2.1.26,3.2.1.64,3.2.1.65,3.2.1.80,3.2.1.91 ko:K01193,ko:K01212,ko:K02809,ko:K02810,ko:K03332,ko:K18775,ko:K19668 ko00051,ko00052,ko00500,ko01100,ko02020,ko02060,map00051,map00052,map00500,map01100,map02020,map02060 M00269 R00801,R00802,R00811,R00879,R02410,R02886,R03635,R03921,R05624,R06088,R10784,R11308,R11311 RC00017,RC00028,RC00077,RC00799,RC03206,RC03278 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.1,4.A.1.2.10,4.A.1.2.12,4.A.1.2.9 GH32,GH6 iE2348C_1286.E2348C_2556,iEC55989_1330.EC55989_2656,iECIAI1_1343.ECIAI1_2428,iECSF_1327.ECSF_2568,iYO844.BSU38040 Glyco_hydro_32C,Glyco_hydro_32N k59_70698_1 1197951.I6R9K8_9CAUD 4.67e-36 132.0 4QFIC@10239|Viruses,4QXG2@35237|dsDNA viruses no RNA stage,4QTVA@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_285436_1 483216.BACEGG_00580 5.02e-39 145.0 COG3969@1|root,COG3969@2|Bacteria,4NJR7@976|Bacteroidetes,2FMUJ@200643|Bacteroidia,4AMYJ@815|Bacteroidaceae 976|Bacteroidetes S Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - DUF3440,PAPS_reduct k59_96803_1 1122605.KB893643_gene665 5.02e-16 82.8 COG3378@1|root,COG3378@2|Bacteria,4NNKX@976|Bacteroidetes,1ISH6@117747|Sphingobacteriia 976|Bacteroidetes L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - Prim-Pol k59_110167_1 478749.BRYFOR_08524 2.66e-27 110.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Terminase_1 k59_110167_2 742733.HMPREF9469_05034 1.53e-12 66.2 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia,223KD@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_205121_1 1420600.W5RNT1_9CIRC 2.45e-19 87.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_205121_2 1618248.A0A0C5IB82_9CIRC 7.03e-30 118.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_29566_1 305700.B447_04913 1e-39 147.0 29X11@1|root,30IPB@2|Bacteria,1PQ6K@1224|Proteobacteria,2WB3D@28216|Betaproteobacteria,2KZI9@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_72826_4 749222.Nitsa_1194 5.23e-24 98.2 2AJ1X@1|root,319K5@2|Bacteria,1RK0X@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2829) - - - - - - - - - - - - DUF2829 k59_72826_5 742766.HMPREF9455_03088 1.24e-10 62.8 2AJ1X@1|root,319K5@2|Bacteria,4NURY@976|Bacteroidetes,2FUGH@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF2829) - - - - - - - - - - - - DUF2829 k59_342420_1 1051675.G0YQF1_9CAUD 2.99e-16 79.0 4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_342420_3 1173762.S4TP25_9CAUD 1.4e-90 302.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_342420_4 1173762.S4TP25_9CAUD 1.05e-37 144.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_207190_1 476272.RUMHYD_01755 8.36e-05 50.1 COG3860@1|root,COG3860@2|Bacteria,1UBEF@1239|Firmicutes,258T3@186801|Clostridia,3Y212@572511|Blautia 2|Bacteria L GIY-YIG type nucleases (URI domain) - - - - - - - - - - - - DUF2087,GIY-YIG,HTH_20,NUMOD3 k59_179484_1 478749.BRYFOR_08514 2.3e-37 129.0 2ARVA@1|root,31H70@2|Bacteria,1V7JT@1239|Firmicutes,24JPE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - HK97-gp10_like k59_98630_1 1692242.A0A0K1RKZ2_9CIRC 1.92e-43 157.0 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_98630_2 1692250.A0A0K1RLR1_9CIRC 2.76e-77 243.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_207200_1 1278073.MYSTI_01906 1.83e-23 103.0 2C5MK@1|root,3010G@2|Bacteria,1RA3G@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_207200_2 753084.F4YCM7_9CAUD 5.24e-18 77.0 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_72838_4 1150864.MILUP08_46631 1.82e-08 58.5 COG1403@1|root,COG1403@2|Bacteria,2GMJV@201174|Actinobacteria,4DDMJ@85008|Micromonosporales 201174|Actinobacteria L endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_358820_1 994573.T472_0216440 1.55e-07 52.8 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,25K68@186801|Clostridia,36PBA@31979|Clostridiaceae 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_76315_1 1504822.CCNO01000015_gene594 1.4e-124 382.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_275123_3 1618247.A0A0C5IMK7_9CIRC 8.49e-14 75.5 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_113735_1 247490.KSU1_C1486 0.000103 46.6 COG1694@1|root,COG1694@2|Bacteria 2|Bacteria FG Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG,MazG-like k59_288984_3 391612.CY0110_27570 2.06e-10 70.1 COG1479@1|root,COG1479@2|Bacteria,1G9G1@1117|Cyanobacteria,3KHRN@43988|Cyanothece 1117|Cyanobacteria S Protein of unknown function DUF262 - - - - - - - - - - - - AlbA_2,DUF262 k59_330247_1 698769.JFBD01000029_gene1313 6.9e-06 53.1 COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,4HIFA@91061|Bacilli,4C6W7@84406|Virgibacillus 91061|Bacilli L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_318824_1 359.CN09_09525 4.86e-27 107.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2UIHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Pathogenesis-related transcriptional factor and ERF protein - - - - - - - - - - - - AP2,HNH_3 k59_194714_1 1416009.V9VHP8_9CAUD 7.53e-18 80.9 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_33985_2 649747.HMPREF0083_01035 2.47e-45 159.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,4HHQR@91061|Bacilli 91061|Bacilli H C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_330415_2 1121101.HMPREF1532_02597 2.34e-66 218.0 COG1783@1|root,COG1783@2|Bacteria,4PMA2@976|Bacteroidetes,2G2CX@200643|Bacteroidia,4AVWS@815|Bacteroidaceae 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_76765_1 285535.JOEY01000007_gene8435 7.92e-22 99.0 COG2730@1|root,COG5492@1|root,COG2730@2|Bacteria,COG5492@2|Bacteria,2GKTR@201174|Actinobacteria 201174|Actinobacteria N polysaccharide lyase family 8 - - 4.2.2.1 ko:K01727 - - - - ko00000,ko01000 - PL8 - Lyase_8,Lyase_8_C,Lyase_8_N k59_20251_1 626887.J057_01665 1.01e-40 154.0 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,1RR0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_249459_1 525256.HMPREF0091_10817 6.59e-26 105.0 COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4CU8F@84998|Coriobacteriia 84998|Coriobacteriia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_382714_1 1121396.KB893122_gene3057 6.47e-47 164.0 COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_2 k59_359140_1 313612.L8106_04811 1.94e-24 107.0 COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1G3EW@1117|Cyanobacteria,1HBBU@1150|Oscillatoriales 1117|Cyanobacteria Q G8 - - - - - - - - - - - - G8,HemolysinCabind,Laminin_G_3,PKD k59_263542_1 1235661.K0ILN4_9CAUD 1.7e-16 82.8 4QFN3@10239|Viruses,4QZSZ@35237|dsDNA viruses no RNA stage,4QQ4M@28883|Caudovirales,4QNXC@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_6313_2 1121451.DESAM_22653 4.49e-53 183.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2WJBW@28221|Deltaproteobacteria,2M8NS@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM ATPase associated with various cellular activities - - - - - - - - - - - - AAA_3,AAA_5 k59_76773_1 697281.Mahau_0077 2.72e-25 112.0 COG0507@1|root,COG0507@2|Bacteria,1TQWH@1239|Firmicutes,24A8I@186801|Clostridia,42HVJ@68295|Thermoanaerobacterales 186801|Clostridia L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_336083_1 1502851.FG93_01932 3.72e-07 56.6 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_188789_1 1082932.ATCR1_06771 5.44e-71 224.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria,4B747@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_430527_2 1618257.A0A0C5IBI9_9CIRC 1.74e-11 69.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_283054_1 488538.SAR116_2345 0.000831 41.6 2EMVQ@1|root,33FHY@2|Bacteria,1NNSC@1224|Proteobacteria,2UWDN@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_239752_1 1121423.JONT01000003_gene1096 0.000304 48.9 COG3409@1|root,COG3773@1|root,COG3409@2|Bacteria,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,24912@186801|Clostridia,261NC@186807|Peptococcaceae 186801|Clostridia M Cell wall hydrolase sleB - 3.5.1.28 ko:K01449 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Hydrolase_2,PG_binding_1 k59_430879_2 5911.EAR93582 2.77e-11 67.4 KOG2756@1|root,KOG2756@2759|Eukaryota,3ZE2R@5878|Ciliophora 5878|Ciliophora T Endonuclease Exonuclease phosphatase family protein - - - ko:K19619 - - - - ko00000,ko01000,ko03400 - - - Exo_endo_phos k59_228715_1 657322.FPR_21870 1.96e-17 82.4 COG3108@1|root,COG3108@2|Bacteria 2|Bacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_430891_1 1618259.A0A0C5I2B5_9CIRC 5.7e-29 116.0 4QE84@10239|Viruses,4QUKR@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_430892_1 1216007.AOPM01000114_gene274 1.92e-14 79.0 2CEG2@1|root,2ZCEX@2|Bacteria,1RB74@1224|Proteobacteria,1S2JC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage replication protein CRI - - - - - - - - - - - - Phage_CRI,Phage_X k59_389478_1 673839.D2J048_9CAUD 1.29e-104 331.0 4QCHV@10239|Viruses,4QUW9@35237|dsDNA viruses no RNA stage,4QQEZ@28883|Caudovirales,4QMEA@10699|Siphoviridae 10699|Siphoviridae S Virulence-associated protein E - - - - - - - - - - - - - k59_228767_1 1408423.JHYA01000006_gene454 3.11e-44 163.0 COG2887@1|root,COG4695@1|root,COG2887@2|Bacteria,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,4H3A0@909932|Negativicutes 909932|Negativicutes L Phage portal protein - - - - - - - - - - - - Phage_portal k59_430897_1 316407.85675770 6.33e-122 350.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,3XMUZ@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_228784_1 1443113.LC20_00489 3.38e-06 46.2 2E1KD@1|root,32WXU@2|Bacteria,1N03N@1224|Proteobacteria,1S94J@1236|Gammaproteobacteria,41GRN@629|Yersinia 1236|Gammaproteobacteria S gpW - - - - - - - - - - - - gpW k59_228784_2 637910.ROD_26011 2.95e-119 362.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria,3WYY1@544|Citrobacter 1236|Gammaproteobacteria S Phage terminase large subunit (GpA) A - 3.1.21.4 ko:K21512 - - - - ko00000,ko01000 - - - Terminase_GpA k59_352425_2 1158292.JPOE01000005_gene396 3.04e-139 409.0 COG0675@1|root,COG0675@2|Bacteria,1MUU0@1224|Proteobacteria,2VJG9@28216|Betaproteobacteria 28216|Betaproteobacteria L TIGRFAM transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_149900_1 861208.AGROH133_06202 1.42e-38 146.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_1269_3 1283077.M1HLI2_9CAUD 1.92e-11 70.1 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_55872_2 1458697.W6EKG4_9CAUD 3.48e-07 52.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QM2K@10699|Siphoviridae 10699|Siphoviridae S Phage Tail Collar Domain - - - - - - - - - - - - - k59_312220_1 674081.D1L2X9_9CAUD 2.12e-18 82.4 4QB9C@10239|Viruses,4QWED@35237|dsDNA viruses no RNA stage,4QTNA@28883|Caudovirales,4QNRK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_163267_1 266779.Meso_1200 3.2e-27 113.0 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria,2UJ12@28211|Alphaproteobacteria,43KMC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_176624_6 1120936.KB907208_gene1066 1.79e-176 514.0 28MN1@1|root,2ZAXN@2|Bacteria,2H2TF@201174|Actinobacteria 201174|Actinobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_176624_7 743721.Psesu_1179 2.79e-09 59.7 2DSRK@1|root,33H6U@2|Bacteria,1P21N@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_419361_2 1788439.A0A190WHD0_9CIRC 2.94e-24 107.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_365621_1 134676.ACPL_6704 1.46e-11 69.7 COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family mycP - - ko:K14645,ko:K14743 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_95838_2 641147.HMPREF9021_02711 1.91e-29 115.0 COG1074@1|root,COG1074@2|Bacteria,1QUUZ@1224|Proteobacteria,2WI1S@28216|Betaproteobacteria 28216|Betaproteobacteria L PDDEXK-like domain of unknown function (DUF3799) - - - - - - - - - - - - DUF3799 k59_352430_2 1165094.RINTHH_3920 5.43e-55 187.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_352430_4 1385658.U5KPZ6_9VIRU 3.35e-201 578.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_216964_1 650150.ERH_1292 5.94e-14 79.7 28MKK@1|root,2ZAWR@2|Bacteria,1UYAT@1239|Firmicutes,3VSD5@526524|Erysipelotrichia 526524|Erysipelotrichia S Putative viral replication protein - - - - - - - - - - - - RNA_helicase,Viral_Rep k59_14780_3 1111454.HMPREF1250_1736 1.35e-09 58.9 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H2W4@909932|Negativicutes 909932|Negativicutes L SNF2 family - - - - - - - - - - - - SNF2_N k59_392691_5 44056.XP_009035090.1 8.31e-12 75.5 COG0553@1|root,KOG0387@2759|Eukaryota 2759|Eukaryota L histone H2A-H2B dimer displacement ERCC6 GO:0000166,GO:0001207,GO:0001208,GO:0001932,GO:0001934,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003682,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006284,GO:0006289,GO:0006325,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0008022,GO:0008023,GO:0008026,GO:0008047,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010212,GO:0010332,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010628,GO:0010767,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019207,GO:0019209,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019887,GO:0019899,GO:0030234,GO:0030295,GO:0030296,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0032147,GO:0032268,GO:0032270,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032784,GO:0032786,GO:0032991,GO:0033554,GO:0033674,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034728,GO:0035639,GO:0036094,GO:0040029,GO:0042325,GO:0042327,GO:0042623,GO:0043085,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043618,GO:0043620,GO:0043933,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044877,GO:0045815,GO:0045859,GO:0045860,GO:0045893,GO:0045935,GO:0045937,GO:0046483,GO:0047485,GO:0048518,GO:0048522,GO:0050730,GO:0050731,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051174,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051276,GO:0051338,GO:0051347,GO:0051716,GO:0060255,GO:0061097,GO:0061098,GO:0065007,GO:0065009,GO:0070013,GO:0070035,GO:0070063,GO:0071103,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0098772,GO:0104004,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K10841 ko03420,map03420 - - - ko00000,ko00001,ko03036,ko03400 - - - Helicase_C,SNF2_N k59_392691_6 1121871.AUAT01000022_gene1839 6.5e-18 79.0 2E38J@1|root,32Y88@2|Bacteria,1VAXK@1239|Firmicutes,4HNXW@91061|Bacilli 91061|Bacilli S VRR-NUC domain protein - - - - - - - - - - - - VRR_NUC k59_392691_10 1260356.D920_01722 4.18e-68 242.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli,4B0F6@81852|Enterococcaceae 91061|Bacilli L DNA polymerase family A polA_2 - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_392691_12 1286171.EAL2_808p01520 5.57e-13 77.8 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,25V8B@186806|Eubacteriaceae 186801|Clostridia L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_43397_3 324602.Caur_0322 1.28e-43 159.0 COG2189@1|root,COG2189@2|Bacteria,2G5WR@200795|Chloroflexi,375UV@32061|Chloroflexia 32061|Chloroflexia H PFAM DNA methylase N-4 N-6 domain protein - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_43397_4 1298867.AUES01000073_gene3748 2.62e-05 49.3 2C6KN@1|root,32Y69@2|Bacteria,1N8AV@1224|Proteobacteria,2UKJX@28211|Alphaproteobacteria,3K4VB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S VRR_NUC - - - - - - - - - - - - VRR_NUC k59_16444_2 10752.A0MZC7_BPN4 5.89e-56 199.0 4QBY0@10239|Viruses,4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_218090_2 691965.D4P7D9_9CAUD 4.95e-42 148.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_124193_1 1121904.ARBP01000036_gene2088 1.9e-06 60.5 COG4099@1|root,COG4733@1|root,COG4099@2|Bacteria,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes 976|Bacteroidetes O Fibronectin type III domain protein - - - - - - - - - - - - Laminin_G_3,PA14,fn3 k59_380374_1 691965.D4P7E6_9CAUD 2.89e-96 319.0 4QAK6@10239|Viruses,4R01K@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_57541_1 1313301.AUGC01000003_gene2054 0.000552 51.2 COG0508@1|root,COG0508@2|Bacteria,4NF33@976|Bacteroidetes 976|Bacteroidetes C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_151554_1 512565.AMIS_21510 9.49e-44 157.0 COG0270@1|root,COG0270@2|Bacteria,2I8R8@201174|Actinobacteria,4DFVS@85008|Micromonosporales 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_3037_1 1333998.M2A_3282 7.41e-17 87.0 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,2U3TE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_31928_2 1408428.JNJP01000009_gene1355 2.55e-11 62.8 COG3108@1|root,COG3108@2|Bacteria,1NCZX@1224|Proteobacteria,42VTQ@68525|delta/epsilon subdivisions,2WMR2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_287284_1 545695.TREAZ_0592 8.56e-51 175.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - Dam,PhageMin_Tail k59_316853_1 1291050.JAGE01000002_gene3381 1.89e-06 53.5 28JTW@1|root,2Z9J1@2|Bacteria,1UIV9@1239|Firmicutes,25FDE@186801|Clostridia 186801|Clostridia S Phage replisome organizer, N-terminal domain protein - - - - - - - - - - - - Phage_rep_org_N k59_356589_1 1282361.ABAC402_17790 3.53e-30 125.0 COG3598@1|root,COG3598@2|Bacteria,1R4EA@1224|Proteobacteria,2U8VM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25,DnaB,Prim-Pol k59_153130_2 1429916.X566_19060 2.95e-17 85.9 29WMV@1|root,30I8P@2|Bacteria,1NZGA@1224|Proteobacteria,2UTHJ@28211|Alphaproteobacteria,3K4A8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_180175_1 1116472.MGMO_218c00040 6.91e-122 352.0 COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,1RWGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Beta-lactamase bla - 3.5.2.6 ko:K17836,ko:K18698,ko:K18795,ko:K19217 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_180175_2 34740.HMEL002866-PA 4e-13 67.0 2C410@1|root,2SQ9Y@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_141237_2 172088.AUGA01000082_gene6213 2.4e-23 100.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_99396_1 1396141.BATP01000024_gene780 0.000118 46.6 COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia,2IU0G@203494|Verrucomicrobiae 203494|Verrucomicrobiae K Sigma-70 region 3 - - - - - - - - - - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_356609_1 1046714.AMRX01000006_gene3172 4.87e-18 88.6 COG0503@1|root,COG0827@1|root,COG0503@2|Bacteria,COG0827@2|Bacteria,1PH8A@1224|Proteobacteria,1T6BP@1236|Gammaproteobacteria,469V3@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA restriction-modification system - - - - - - - - - - - - - k59_368811_2 1197951.I6S2A3_9CAUD 1.69e-34 132.0 4QAIV@10239|Viruses,4QYFZ@35237|dsDNA viruses no RNA stage,4QQUY@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_73889_1 537874.B3GVX7_9CAUD 2.42e-07 52.4 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_125419_1 1379722.S5SY31_9CIRC 6.41e-102 304.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_422097_1 478749.BRYFOR_08530 4.89e-45 150.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_273809_1 462590.A9J4Z1_BPPYU 0.000186 47.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_273811_1 86106.I862_02335 3.01e-11 69.3 COG2357@1|root,COG3391@1|root,COG4733@1|root,COG2357@2|Bacteria,COG3391@2|Bacteria,COG4733@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,47F3P@766|Rickettsiales 766|Rickettsiales S GTA TIM-barrel-like domain - - - - - - - - - - - - GTA_TIM,Phage-tail_3 k59_144248_2 7230.FBpp0169987 9.95e-12 66.6 COG5479@1|root,2S2KY@2759|Eukaryota,3A1DX@33154|Opisthokonta,3BS3D@33208|Metazoa,3D8FQ@33213|Bilateria,429YY@6656|Arthropoda,3SZE3@50557|Insecta,44XAP@7147|Diptera,45ZHA@7214|Drosophilidae 33208|Metazoa G N-acetylmuramoyl-L-alanine amidase activity. It is involved in the biological process described with peptidoglycan catabolic process PGLYRP1 GO:0001775,GO:0001817,GO:0001818,GO:0001906,GO:0002218,GO:0002221,GO:0002252,GO:0002253,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002757,GO:0002758,GO:0002764,GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006887,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0007154,GO:0007165,GO:0008150,GO:0008329,GO:0009595,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0012505,GO:0016019,GO:0016045,GO:0016192,GO:0019730,GO:0023052,GO:0030139,GO:0030141,GO:0031341,GO:0031343,GO:0031347,GO:0031348,GO:0031349,GO:0031410,GO:0031640,GO:0031974,GO:0031982,GO:0031983,GO:0032101,GO:0032102,GO:0032649,GO:0032689,GO:0032814,GO:0032815,GO:0032823,GO:0032824,GO:0032826,GO:0032827,GO:0032940,GO:0034774,GO:0035580,GO:0035821,GO:0036230,GO:0038023,GO:0038187,GO:0040007,GO:0042119,GO:0042268,GO:0042581,GO:0042742,GO:0042749,GO:0042752,GO:0042834,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0043299,GO:0043312,GO:0043900,GO:0043902,GO:0044110,GO:0044116,GO:0044117,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045087,GO:0045088,GO:0045089,GO:0045187,GO:0045321,GO:0045335,GO:0045595,GO:0045596,GO:0045619,GO:0045620,GO:0045919,GO:0046903,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050727,GO:0050728,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050830,GO:0050865,GO:0050866,GO:0050896,GO:0051093,GO:0051179,GO:0051234,GO:0051239,GO:0051241,GO:0051249,GO:0051250,GO:0051606,GO:0051704,GO:0051707,GO:0051709,GO:0051710,GO:0051712,GO:0051714,GO:0051716,GO:0060089,GO:0060205,GO:0061844,GO:0065007,GO:0070013,GO:0070820,GO:0071682,GO:0080134,GO:0097013,GO:0097367,GO:0097708,GO:0098542,GO:0098543,GO:0098581,GO:0099503,GO:1902105,GO:1902106,GO:1903706,GO:1903707,GO:1904724,GO:2000026 - ko:K01446 - - R04112 RC00064,RC00141 ko00000 - - - Amidase_2 k59_263672_1 351016.RAZWK3B_00515 2.08e-41 152.0 COG0582@1|root,COG0582@2|Bacteria,1R43H@1224|Proteobacteria,2TT0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_101491_1 999413.HMPREF1094_01139 0.00063 47.4 COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,3VNXN@526524|Erysipelotrichia 526524|Erysipelotrichia K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_76934_1 1283079.M1IDA0_9CAUD 1.43e-12 63.5 4QAZF@10239|Viruses,4QUTY@35237|dsDNA viruses no RNA stage,4QPH6@28883|Caudovirales 28883|Caudovirales S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_411751_1 1403819.BATR01000046_gene1343 4.3e-43 163.0 COG3941@1|root,COG3941@2|Bacteria,46Z3Y@74201|Verrucomicrobia,2IWBM@203494|Verrucomicrobiae 203494|Verrucomicrobiae S tape measure - - - - - - - - - - - - - k59_330527_1 525909.Afer_1638 1.03e-96 313.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_319313_2 373126.Q2A089_9VIRU 5.09e-05 49.7 4QC24@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_382800_1 1292020.H483_0109830 2.14e-10 60.1 2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whiB3 - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_382800_2 743721.Psesu_1508 3.82e-08 63.9 COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1X3ND@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyltransferases involved in cell wall biogenesis - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_303564_2 526227.Mesil_1197 6.83e-19 89.0 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_211128_4 1120934.KB894421_gene2529 1.01e-06 57.4 COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4E10H@85010|Pseudonocardiales 201174|Actinobacteria M N-acetylmuramoyl-L-alanine amidase cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,PG_binding_1 k59_277530_2 1268622.AVS7_00692 7.22e-14 72.8 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2VXCX@28216|Betaproteobacteria,4AIH5@80864|Comamonadaceae 28216|Betaproteobacteria S HNH endonuclease - - - - - - - - - - - - AP2,HNH_3 k59_277530_4 1122962.AULH01000008_gene2218 2.3e-05 46.2 2BPEW@1|root,32I73@2|Bacteria,1Q1QK@1224|Proteobacteria,2VB3T@28211|Alphaproteobacteria,3711V@31993|Methylocystaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_277530_6 1249997.JHZW01000003_gene3734 7.04e-05 54.3 COG1511@1|root,COG3210@1|root,COG1511@2|Bacteria,COG3210@2|Bacteria,4PKI0@976|Bacteroidetes,1IKUE@117743|Flavobacteriia,2PI31@252356|Maribacter 976|Bacteroidetes U PFAM Collagen triple helix repeat (20 copies) - - - - - - - - - - - - - k59_347880_1 1564096.A0A0A0YS43_9CAUD 1.39e-19 91.7 4QBA2@10239|Viruses,4QPPI@28883|Caudovirales,4QIA3@10662|Myoviridae 10662|Myoviridae S Thymidylate synthase - - - - - - - - - - - - - k59_221840_1 85643.Tmz1t_0372 2e-05 52.8 COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,2VM8C@28216|Betaproteobacteria,2KYHS@206389|Rhodocyclales 206389|Rhodocyclales L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_22893_1 1177928.TH2_05208 3.19e-15 85.5 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,2JV2T@204441|Rhodospirillales 204441|Rhodospirillales S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Lambda_tail_I,Phage-tail_3 k59_103758_1 1121100.JCM6294_535 1.99e-10 61.2 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,2FRI5@200643|Bacteroidia,4ATW7@815|Bacteroidaceae 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_103758_2 521097.Coch_0880 1.14e-149 449.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,1I7WE@117743|Flavobacteriia,1EQNF@1016|Capnocytophaga 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_116267_1 411460.RUMTOR_01335 1.14e-60 210.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_425989_1 266117.Rxyl_0852 6.43e-41 150.0 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CPNU@84995|Rubrobacteria 84995|Rubrobacteria L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_372472_1 456442.Mboo_1423 7.83e-10 69.7 COG0068@1|root,COG3291@1|root,arCOG03991@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG03956@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia 224756|Methanomicrobia O PFAM PKD domain containing protein - - - - - - - - - - - - PKD k59_292100_4 1158601.I585_01172 1.93e-17 80.5 2EC8I@1|root,33670@2|Bacteria,1VENI@1239|Firmicutes,4HR98@91061|Bacilli,4B4AS@81852|Enterococcaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_49478_2 411460.RUMTOR_01339 1.34e-53 175.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_49478_3 742740.HMPREF9474_02267 2.15e-82 252.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia,221N8@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_170368_1 65393.PCC7424_3850 7.38e-70 238.0 COG0553@1|root,COG2263@1|root,COG0553@2|Bacteria,COG2263@2|Bacteria,1G4K0@1117|Cyanobacteria,3KG7H@43988|Cyanothece 1117|Cyanobacteria H C-terminal domain on Strawberry notch homologue - - - - - - - - - - - - AAA_34,Helicase_C_4,MTS k59_91353_2 1041147.AUFB01000014_gene329 1.88e-20 89.0 2CXZV@1|root,32T32@2|Bacteria,1N4R9@1224|Proteobacteria,2UM96@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_399446_1 1234888.K0A2J2_9VIRU 1.29e-45 163.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_25295_2 402777.KB235898_gene5458 8.15e-30 119.0 COG4990@1|root,COG4990@2|Bacteria,1GHGJ@1117|Cyanobacteria,1HHUK@1150|Oscillatoriales 1117|Cyanobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2 k59_39161_2 1051675.G0YQH7_9CAUD 9.34e-46 159.0 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_374372_1 445688.E3SNK9_9CAUD 0.00064 43.1 4QCZH@10239|Viruses,4QPND@28883|Caudovirales,4QI11@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4 gp9/10-like protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_106091_1 358220.C380_12140 4.72e-16 78.2 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_106091_2 1485544.JQKP01000016_gene696 3.51e-14 76.3 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2VRW1@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_224164_1 1122201.AUAZ01000021_gene3149 3.5e-108 333.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_428199_2 1300143.CCAV010000006_gene4340 1.11e-15 74.7 COG0863@1|root,COG0863@2|Bacteria,4NQQ1@976|Bacteroidetes,1I957@117743|Flavobacteriia,3ZRIJ@59732|Chryseobacterium 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_401607_1 470145.BACCOP_01609 6.51e-49 177.0 28JQ1@1|root,2Z9FZ@2|Bacteria,4NFNV@976|Bacteroidetes,2FMFK@200643|Bacteroidia,4AKH0@815|Bacteroidaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - PcfJ k59_11128_1 56780.SYN_02966 4.6e-84 271.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_132904_2 1128421.JAGA01000003_gene3691 2.78e-26 113.0 COG0420@1|root,COG0420@2|Bacteria,2NQ16@2323|unclassified Bacteria 2|Bacteria L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03546,ko:K03547 - - - - ko00000,ko03400 - - - Metallophos k59_93737_1 398580.Dshi_2167 1.01e-13 72.0 COG5281@1|root,COG5281@2|Bacteria,1R47M@1224|Proteobacteria,2TUIV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG5281, Phage-related minor tail protein - - - - - - - - - - - - - k59_93737_3 1000565.METUNv1_01676 3.93e-07 53.5 COG0791@1|root,COG0791@2|Bacteria,1NA3R@1224|Proteobacteria,2VXXX@28216|Betaproteobacteria 28216|Betaproteobacteria M to Bacteriophage D3 Orf25 SWALL Q9MC96 (EMBL AF165214) (135 aa) fasta scores E() 0.00047, 30.46 id in 128 aa - - - - - - - - - - - - NLPC_P60 k59_25323_1 1232683.ADIMK_0915 2.8e-10 62.4 28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,1S23F@1236|Gammaproteobacteria,46AAN@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_25323_2 1250232.JQNJ01000001_gene1995 4.16e-06 50.4 COG2520@1|root,COG2520@2|Bacteria,4NVH3@976|Bacteroidetes,1IKD5@117743|Flavobacteriia 976|Bacteroidetes J Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_93739_1 1301098.PKB_0587 1.85e-07 52.4 2E16H@1|root,32WMB@2|Bacteria,1N6EU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_200463_1 634500.EbC_32190 3.32e-22 92.4 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1T9QJ@1236|Gammaproteobacteria,3X7X3@551|Erwinia 1236|Gammaproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_11500_2 883114.HMPREF9709_01184 3.86e-29 131.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,22H39@1570339|Peptoniphilaceae 186801|Clostridia S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_309190_2 1283300.ATXB01000002_gene2517 6.97e-13 77.4 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1TAY2@1236|Gammaproteobacteria,1XGEB@135618|Methylococcales 135618|Methylococcales D tape measure protein - - - - - - - - - - - - - k59_161936_1 1197951.I6RT34_9CAUD 2.07e-59 198.0 4QGAG@10239|Viruses,4R0KB@35237|dsDNA viruses no RNA stage,4QUA4@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_404691_1 1234888.K0A2J2_9VIRU 8.73e-48 171.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_283301_1 411460.RUMTOR_01350 3.27e-13 73.6 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_269837_1 478749.BRYFOR_08565 2.14e-41 146.0 2A0KC@1|root,2ZGJK@2|Bacteria,1V2JS@1239|Firmicutes,24H6R@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_418155_12 340099.Teth39_1968 0.000136 44.7 COG0640@1|root,COG0640@2|Bacteria,1V6CU@1239|Firmicutes,24R9E@186801|Clostridia,42IF6@68295|Thermoanaerobacterales 186801|Clostridia K transcriptional regulator, ArsR - - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 k59_256336_2 1101189.AQUO01000001_gene1430 7.16e-12 69.7 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TRFR@28211|Alphaproteobacteria,2PZ7Z@265|Paracoccus 28211|Alphaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_202423_1 573061.Clocel_0770 2.13e-09 58.5 COG1403@1|root,COG1403@2|Bacteria,1V9Y6@1239|Firmicutes,25DN2@186801|Clostridia,36JXI@31979|Clostridiaceae 186801|Clostridia V HNH endonuclease - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH k59_202423_2 643473.KB235930_gene4273 1.31e-09 71.2 COG5545@1|root,COG5545@2|Bacteria,1G1ZC@1117|Cyanobacteria,1HMTZ@1161|Nostocales 1117|Cyanobacteria L Virulence-associated protein E - - - - - - - - - - - - DUF3854,VirE k59_418165_1 1038860.AXAP01000067_gene8427 1.25e-17 84.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_107987_1 164757.Mjls_3913 1.35e-10 67.8 COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,2395N@1762|Mycobacteriaceae 201174|Actinobacteria L Belongs to the 'phage' integrase family intA - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase k59_107987_2 1129145.H2BD49_9CAUD 8.05e-09 62.8 4QBHS@10239|Viruses,4QUVV@35237|dsDNA viruses no RNA stage,4QPT9@28883|Caudovirales,4QKSP@10699|Siphoviridae 10699|Siphoviridae S DNA metabolic process - - - - - - - - - - - - - k59_215903_2 1054213.HMPREF9946_02188 2.39e-24 100.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2U64S@28211|Alphaproteobacteria,2JY8C@204441|Rhodospirillales 204441|Rhodospirillales H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_69139_4 1203606.HMPREF1526_01348 9.64e-39 159.0 COG5280@1|root,COG5283@1|root,COG5280@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,25E9Q@186801|Clostridia,36USH@31979|Clostridiaceae 186801|Clostridia D phage tail tape measure protein - - - - - - - - - - - - LysM,Peptidase_M23,PhageMin_Tail k59_216938_2 1536592.A0A088F776_9VIRU 1.73e-22 102.0 4QF7M@10239|Viruses 10239|Viruses S AAA domain - - - - - - - - - - - - - k59_419348_3 1123288.SOV_2c00060 2.5e-08 66.2 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups alg8 - 2.4.1.33 ko:K19290 ko00051,map00051 - R08692 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.7,4.D.1.1.9 GT2 - Glyco_tranf_2_3,Glycos_transf_2,HATPase_c,HisKA,Response_reg k59_284559_2 927677.ALVU02000001_gene2872 1.87e-140 414.0 COG0500@1|root,COG0500@2|Bacteria,1GHCT@1117|Cyanobacteria,1H6IJ@1142|Synechocystis 1117|Cyanobacteria Q C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_28549_2 1618257.A0A0C5IBI9_9CIRC 1.74e-30 124.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1255_1 1462526.BN990_01821 2.7e-15 75.1 COG3935@1|root,COG3935@2|Bacteria,1V9YA@1239|Firmicutes,4HN3B@91061|Bacilli 91061|Bacilli L primosome component and related proteins - - - - - - - - - - - - DnaB_2 k59_1255_3 697281.Mahau_0558 6.76e-18 80.1 COG4570@1|root,COG4570@2|Bacteria,1VFJ9@1239|Firmicutes,24NSB@186801|Clostridia 186801|Clostridia L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC - - - - - - - - - - - - RusA k59_1255_4 68570.DC74_2935 1.74e-05 47.8 2AV32@1|root,31KT0@2|Bacteria,2IM6S@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_230561_1 351746.Pput_4113 1.94e-115 346.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,1RNR0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_176771_1 1140.Synpcc7942_0099 9.11e-14 68.9 COG1694@1|root,COG1694@2|Bacteria,1G25W@1117|Cyanobacteria,1H41T@1129|Synechococcus 1117|Cyanobacteria S MazG nucleotide pyrophosphohydrolase domain - - - - - - - - - - - - MazG k59_176771_2 1392490.JHZX01000001_gene3594 9.86e-12 63.5 2E645@1|root,330T3@2|Bacteria 2|Bacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_271148_1 1127692.HMPREF9075_00026 4.37e-25 121.0 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria,4NF3E@976|Bacteroidetes,1I066@117743|Flavobacteriia,1ERB7@1016|Capnocytophaga 976|Bacteroidetes D Tape measure domain protein - - - - - - - - - - - - - k59_407642_3 316067.Geob_0876 1.1e-08 67.4 COG1572@1|root,COG3391@1|root,COG5434@1|root,COG1572@2|Bacteria,COG3391@2|Bacteria,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Beta_helix,CARDB,CBM_35,Calx-beta,F5_F8_type_C k59_2868_2 1227261.HMPREF0043_00106 9.98e-15 81.6 COG0270@1|root,COG0270@2|Bacteria,2GJR6@201174|Actinobacteria,4D5EN@85005|Actinomycetales 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_2875_1 1111069.TCCBUS3UF1_2130 6.41e-83 272.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1WIR6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Ribonucleoside-diphosphate reductase - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN k59_231444_1 913865.DOT_2884 4.33e-17 86.3 COG5301@1|root,COG5301@2|Bacteria,1UYV6@1239|Firmicutes,24GI3@186801|Clostridia 186801|Clostridia G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_84564_1 1385658.U5KNR1_9VIRU 1.02e-58 194.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_71785_3 754331.AEME01000001_gene3035 5.14e-15 76.6 28H9R@1|root,2Z7MD@2|Bacteria,1MVTR@1224|Proteobacteria,1RMPH@1236|Gammaproteobacteria,3XNIG@561|Escherichia 1236|Gammaproteobacteria S Escherichia coli O157 H7 ortholog z1655 yfjQ - - - - - - - - - - - DUF932 k59_84566_2 1125863.JAFN01000001_gene3559 3.77e-08 55.1 2DS6A@1|root,33ERD@2|Bacteria,1Q2WN@1224|Proteobacteria,4328V@68525|delta/epsilon subdivisions,2WXUD@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_354519_3 446471.Xcel_2482 0.000284 47.0 COG1876@1|root,COG1876@2|Bacteria,2ICD5@201174|Actinobacteria,4F4E5@85017|Promicromonosporaceae 201174|Actinobacteria M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - VanY k59_246011_2 471874.PROSTU_03779 5.66e-24 95.9 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria,3Z96P@586|Providencia 1236|Gammaproteobacteria H synthase queD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - iECIAI39_1322.ECIAI39_2947,iUTI89_1310.UTI89_C3129,ic_1306.c3324 PTPS k59_246011_3 1282876.BAOK01000001_gene2180 6.36e-58 189.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_246011_4 745411.B3C1_16566 1.38e-61 198.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1J5W1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_2947_4 1410670.JHXF01000019_gene56 2.5e-07 56.2 COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,3WKUR@541000|Ruminococcaceae 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_2947_9 1496688.ER33_05200 2.29e-19 99.8 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1G1P1@1117|Cyanobacteria,22SJI@167375|Cyanobium 1117|Cyanobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_2947_11 759914.BP951000_1609 1.41e-05 54.3 COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes 203691|Spirochaetes L Uracil-DNA glycosylase, family 4 ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_2947_12 1469948.JPNB01000003_gene50 3.75e-18 83.6 2CGYE@1|root,31NJV@2|Bacteria,1V7Z1@1239|Firmicutes,24GBB@186801|Clostridia,36GTI@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4406 k59_407903_1 478749.BRYFOR_08560 3.39e-42 158.0 COG3378@1|root,COG3378@2|Bacteria 2|Bacteria KL Phage plasmid primase P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,DUF3854,P22_AR_N,Pox_D5 k59_357258_3 105154.Q9MBU3_9VIRU 1.39e-06 55.8 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_357258_4 2003327.CAPSD_BPCHP 3.91e-52 180.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_142029_1 1196324.A374_08819 0.000121 50.4 2DPIQ@1|root,3328X@2|Bacteria,1VFYC@1239|Firmicutes,4HNHQ@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - AP2 k59_125890_4 398525.KB900701_gene6144 9.84e-27 108.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria,3JU4C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_4932_2 1096546.WYO_0171 8.16e-24 103.0 COG0553@1|root,COG0553@2|Bacteria,1PXS8@1224|Proteobacteria,2UAZ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria KL COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_87060_1 1123288.SOV_2c10450 1.62e-136 397.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4H3N6@909932|Negativicutes 909932|Negativicutes L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_317519_3 1121344.JHZO01000001_gene404 8.43e-27 111.0 COG0438@1|root,COG0438@2|Bacteria,1UVI4@1239|Firmicutes,25KIQ@186801|Clostridia,3WQRB@541000|Ruminococcaceae 186801|Clostridia M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_233379_1 1458357.BG58_11025 5.55e-20 89.4 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,1KAW7@119060|Burkholderiaceae 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_317733_2 1120971.AUCA01000053_gene371 1.14e-32 122.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_369414_3 310539.Q5G7P7_9CAUD 2.92e-58 188.0 4QGB5@10239|Viruses,4QXR2@35237|dsDNA viruses no RNA stage,4QSQD@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_369414_4 1150990.H6WYG3_9CAUD 9.17e-60 211.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_369414_5 1123288.SOV_6c00580 3.94e-06 53.5 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H28F@909932|Negativicutes 909932|Negativicutes L Psort location Cytoplasmic, score 8.96 - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_155962_1 1327982.R9ZYM1_9CAUD 1.19e-127 365.0 4QD0J@10239|Viruses,4R0A5@35237|dsDNA viruses no RNA stage,4QSK9@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_155962_3 313594.PI23P_04622 2.34e-26 103.0 COG2003@1|root,COG2003@2|Bacteria,4NRCM@976|Bacteroidetes,1I1KW@117743|Flavobacteriia 976|Bacteroidetes L DNA repair protein - - - ko:K03630 - - - - ko00000 - - - RadC k59_290013_1 316057.RPD_1986 9.5e-11 65.1 COG5281@1|root,COG5281@2|Bacteria,1R47M@1224|Proteobacteria,2TUIV@28211|Alphaproteobacteria,3JY6I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG5281, Phage-related minor tail protein - - - - - - - - - - - - - k59_145192_1 1121937.AUHJ01000009_gene1510 1.21e-62 214.0 COG0823@1|root,COG0823@2|Bacteria,1R4CN@1224|Proteobacteria,1S0NH@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40 k59_211772_1 1609634.A0A0C5AFT2_9VIRU 9.06e-14 74.3 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_424619_4 365528.KB891219_gene825 2.72e-64 206.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_transf_7C,Glycos_transf_1,Glycos_transf_2 k59_424619_5 234267.Acid_1987 9.65e-55 182.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity bioC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23 k59_371180_1 471870.BACINT_02219 7.35e-33 126.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_360328_2 1133293.H2EIC0_9CAUD 1.59e-21 103.0 4QAK6@10239|Viruses,4QXWJ@35237|dsDNA viruses no RNA stage,4QPID@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_424627_1 497964.CfE428DRAFT_3808 2.72e-61 202.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity mtsE - - - - - - - - - - - TROVE,VWA_2 k59_78213_1 646529.Desaci_4085 3.9e-22 99.0 COG4974@1|root,COG4974@2|Bacteria,1V2D0@1239|Firmicutes,25C40@186801|Clostridia,263FQ@186807|Peptococcaceae 186801|Clostridia L PFAM Phage integrase, N-terminal SAM-like domain - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_399990_1 1166018.FAES_1856 5.85e-57 191.0 COG0270@1|root,COG0270@2|Bacteria,4P3WE@976|Bacteroidetes 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_292918_1 1609634.A0A0C5AFV4_9VIRU 1.93e-12 66.6 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_116783_1 1235835.C814_01159 7.35e-19 91.7 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WGFC@541000|Ruminococcaceae 186801|Clostridia KL SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_426602_1 1026955.F5B3P3_9CAUD 5.36e-05 48.9 4QJCH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_116794_1 1610834.A0A0C5PSK3_9CAUD 2.92e-07 56.2 4QBR2@10239|Viruses,4QT95@28883|Caudovirales 28883|Caudovirales S metallopeptidase activity - - - - - - - - - - - - - k59_400014_1 479431.Namu_3127 1.29e-22 95.5 COG2453@1|root,COG2453@2|Bacteria 2|Bacteria T phosphatase - - - - - - - - - - - - DSPc k59_363170_1 1123302.KB904184_gene1005 2.31e-12 70.5 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli 91061|Bacilli L DNA polymerase polA_2 - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_252302_1 1174528.JH992893_gene6056 6.7e-46 166.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParB,ParBc k59_400020_2 1609634.A0A0C5AFV4_9VIRU 5.63e-05 44.7 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_386157_1 856793.MICA_990 2.31e-83 262.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2TT5T@28211|Alphaproteobacteria,4BQCW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46,4.2.1.76,5.1.3.2 ko:K01710,ko:K01784,ko:K12450 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R00293,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_386157_4 1122138.AQUZ01000081_gene4854 1.62e-15 85.9 COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4DPN1@85009|Propionibacteriales 201174|Actinobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family udgA - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_25533_2 937777.Deipe_0478 2.21e-25 107.0 28W6R@1|root,2ZI7D@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_295831_2 1036674.A28LD_0252 5.74e-10 63.2 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,2QFIM@267893|Idiomarinaceae 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_93968_1 1443665.JACA01000095_gene1961 8.77e-06 53.1 2CGEU@1|root,33PKU@2|Bacteria,4P032@976|Bacteroidetes,1I88M@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_106334_1 204773.HEAR0694 4e-55 190.0 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,2VISI@28216|Betaproteobacteria,473AC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - DUF932 k59_186454_1 31234.CRE12953 1.11e-13 84.0 2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria,40FF9@6231|Nematoda,1KYD3@119089|Chromadorea 33208|Metazoa - - - - - - - - - - - - - - DNA_pol_B_2,Rho_N k59_118578_2 1401446.V6F7R7_9CAUD 4.97e-11 65.9 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QNBP@10744|Podoviridae 10744|Podoviridae S N-methyltransferase activity - - - - - - - - - - - - - k59_416928_2 1035308.AQYY01000002_gene859 0.000138 48.9 COG1409@1|root,COG4932@1|root,COG1409@2|Bacteria,COG4932@2|Bacteria,1UNMY@1239|Firmicutes,25H2U@186801|Clostridia,267I4@186807|Peptococcaceae 2|Bacteria M domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3,CHU_C,Metallophos k59_161295_3 398578.Daci_3220 6.25e-24 111.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,4A9KD@80864|Comamonadaceae 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_161295_4 343509.SG1178 1.66e-08 63.2 2DJ9J@1|root,30546@2|Bacteria,1RFGJ@1224|Proteobacteria,1S4YV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_161295_11 595536.ADVE02000001_gene3187 4.12e-30 108.0 2E4KF@1|root,32ZFE@2|Bacteria,1NCMR@1224|Proteobacteria,2UHT7@28211|Alphaproteobacteria,370KU@31993|Methylocystaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_161295_14 743721.Psesu_1131 1.28e-122 360.0 COG5377@1|root,COG5377@2|Bacteria,1MWP8@1224|Proteobacteria,1RN9Q@1236|Gammaproteobacteria,1X5CX@135614|Xanthomonadales 135614|Xanthomonadales L COG5377 Phage-related protein - - - - - - - - - - - - YqaJ k59_161295_15 580332.Slit_1947 1.41e-130 381.0 28KIJ@1|root,2ZA3S@2|Bacteria,1R4PD@1224|Proteobacteria,2VP07@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_161295_19 520999.PROVALCAL_02037 5.55e-65 218.0 COG0582@1|root,COG0582@2|Bacteria,1MX7E@1224|Proteobacteria,1RNX5@1236|Gammaproteobacteria,3Z97K@586|Providencia 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family intE GO:0003674,GO:0005488,GO:0005515,GO:0046982,GO:0046983 - ko:K21039 - - - - ko00000,ko01000 - - - Arm-DNA-bind_1,Phage_integrase k59_161295_28 537013.CLOSTMETH_02944 2.43e-11 72.0 COG1649@1|root,COG3408@1|root,COG1649@2|Bacteria,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia 186801|Clostridia G Alpha-L-rhamnosidase N-terminal domain protein - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_161295_30 1189612.A33Q_0138 7.42e-10 67.4 COG1404@1|root,COG3227@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,4NF1M@976|Bacteroidetes,47NC9@768503|Cytophagia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8,SPOR k59_161295_32 392500.Swoo_3150 1.48e-09 67.4 COG3210@1|root,COG3637@1|root,COG4733@1|root,COG4886@1|root,COG3210@2|Bacteria,COG3637@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria,1QUXB@1224|Proteobacteria,1T32K@1236|Gammaproteobacteria 1236|Gammaproteobacteria U HemY domain protein - - - - - - - - - - - - Big_5,Cadherin_3,Calx-beta,DUF4347,He_PIG,OmpA_membrane k59_309432_2 1500386.A0A060AFF3_9CAUD 4.46e-18 82.8 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_239840_1 1384066.JAGT01000001_gene956 1.2e-21 98.6 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WH0A@541000|Ruminococcaceae 186801|Clostridia L helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_376995_1 475178.B2BTL9_9CAUD 4.16e-47 174.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_226924_1 1235659.S4T941_9CAUD 9.45e-17 82.8 4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_240668_1 1123237.Salmuc_02912 1.29e-196 574.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_336899_2 106648.BBLJ01000003_gene1842 8.32e-05 45.4 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria 1236|Gammaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_240673_1 1283079.M1HMA6_9CAUD 5.97e-22 99.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QNBW@10744|Podoviridae 10744|Podoviridae S DNA helicase activity - - - - - - - - - - - - - k59_228036_2 1235457.C404_06860 2.78e-20 89.7 COG0438@1|root,COG0438@2|Bacteria,1PJ7G@1224|Proteobacteria,2W2A5@28216|Betaproteobacteria,1KDRM@119060|Burkholderiaceae 28216|Betaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_transf_4 k59_388900_2 1561065.A0A0B5A580_9CAUD 1.06e-95 308.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_336969_1 269796.Rru_A1959 4.34e-13 70.1 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,2JRQP@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_283280_1 1423144.Gal_02288 1.69e-26 105.0 COG1403@1|root,COG1403@2|Bacteria,1N0FM@1224|Proteobacteria,2TWQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ERF superfamily - - - - - - - - - - - - ERF k59_283280_2 670292.JH26_14425 9.2e-06 49.3 2DIG9@1|root,3036R@2|Bacteria,1RBPA@1224|Proteobacteria,2U6EP@28211|Alphaproteobacteria,1JV25@119045|Methylobacteriaceae 28211|Alphaproteobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_404670_1 1416009.V9VFA4_9CAUD 9.58e-91 293.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_54022_2 1123057.P872_22010 3.47e-13 73.9 COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,4NFC3@976|Bacteroidetes,47PUU@768503|Cytophagia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_283290_2 743299.Acife_2298 4.17e-15 82.0 COG0640@1|root,COG0640@2|Bacteria,1N0B6@1224|Proteobacteria,1S9GJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_188898_1 292414.TM1040_0801 1.71e-07 52.8 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,2UHZA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_188898_5 521097.Coch_0900 7.45e-28 108.0 2C091@1|root,32UF3@2|Bacteria,4NSYS@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_377726_1 1331060.RLDS_16020 5.1e-53 182.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,2K42P@204457|Sphingomonadales 204457|Sphingomonadales S Terminase - - - - - - - - - - - - Terminase_1 k59_67545_1 626523.GCWU000342_00981 3.74e-23 103.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_175409_2 44056.XP_009041542.1 2.64e-14 74.3 2E552@1|root,2SBZD@2759|Eukaryota 44056.XP_009041542.1|- S HNH endonuclease - - - - - - - - - - - - - k59_244379_3 272630.MexAM1_META1p4009 2.12e-10 65.9 COG4675@1|root,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein - - - - - - - - - - - - Collagen,Collar k59_257687_2 411469.EUBHAL_02730 6.18e-09 59.3 COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,25W7R@186806|Eubacteriaceae 186801|Clostridia F Psort location Cytoplasmic, score comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_257687_4 1123320.KB889675_gene3998 1.4e-95 287.0 COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - iNJ661.Rv2754c Thy1 k59_257687_6 1064537.AGSO01000007_gene3228 6.94e-06 52.0 COG0242@1|root,COG0242@2|Bacteria,2GNZ9@201174|Actinobacteria,4FC6G@85020|Dermabacteraceae 201174|Actinobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_257687_9 649831.L083_7465 6.21e-148 435.0 COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4D9BM@85008|Micromonosporales 201174|Actinobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH2 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_352455_1 438753.AZC_0840 3.05e-10 67.8 COG3170@1|root,COG3170@2|Bacteria,1R69E@1224|Proteobacteria,2U3B9@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - - k59_339062_1 570952.ATVH01000011_gene364 1.34e-63 217.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,2UQEG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1285_1 1479238.JQMZ01000001_gene2201 1.01e-49 172.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2U64S@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_82574_1 1038860.AXAP01000015_gene2003 7.3e-17 85.1 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_109244_2 869209.Tresu_0331 0.000859 45.8 28JPN@1|root,2Z9FN@2|Bacteria,2J96Y@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_325608_4 1300143.CCAV010000006_gene4312 2.78e-51 175.0 COG4653@1|root,COG4653@2|Bacteria,4P9ZK@976|Bacteroidetes,1IM07@117743|Flavobacteriia,3ZTHB@59732|Chryseobacterium 976|Bacteroidetes S Phage capsid family - - - - - - - - - - - - - k59_82778_1 1173762.S4TT79_9CAUD 1.02e-75 236.0 4QGM6@10239|Viruses,4QYNV@35237|dsDNA viruses no RNA stage,4QRH4@28883|Caudovirales,4QP0P@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_56035_1 722417.D5GV46_9CAUD 1.51e-25 116.0 4QEIG@10239|Viruses,4R0E7@35237|dsDNA viruses no RNA stage,4QTGA@28883|Caudovirales,4QJNG@10662|Myoviridae 10662|Myoviridae S regulation of transcription, DNA-dependent - - - - - - - - - - - - - k59_176808_1 1267580.AF6_1179 6.7e-42 149.0 COG0175@1|root,COG0175@2|Bacteria,1TQBQ@1239|Firmicutes,4HD3W@91061|Bacilli 91061|Bacilli EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_230592_3 202954.BBNK01000034_gene3794 1.28e-38 133.0 2A3Q7@1|root,30S7S@2|Bacteria,1NP2K@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_312535_2 1433287.X808_8750 1.26e-19 89.0 2A78P@1|root,30W55@2|Bacteria,1RGCT@1224|Proteobacteria,1TFFA@1236|Gammaproteobacteria,1Y8D9@135625|Pasteurellales 135625|Pasteurellales - - - - - - - - - - - - - - - k59_85686_1 1203567.HMPREF1286_00421 2.47e-09 60.5 2AV5J@1|root,31KVW@2|Bacteria,2HPM8@201174|Actinobacteria,22PZ7@1653|Corynebacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_85686_3 44088.Q6VZJ4_CNPV 1.48e-25 106.0 4QB1C@10239|Viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_72812_2 882.DVU_2165 1.21e-36 130.0 COG0741@1|root,COG0741@2|Bacteria,1NAJM@1224|Proteobacteria,43233@68525|delta/epsilon subdivisions,2WX5F@28221|Deltaproteobacteria,2MD5A@213115|Desulfovibrionales 28221|Deltaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_368156_1 1121877.JQKF01000027_gene2474 4.46e-48 174.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_408747_2 105154.Q9MBU6_9VIRU 3.03e-73 238.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_394974_2 888727.HMPREF9092_0406 1.33e-07 58.9 COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,3WCK1@538999|Clostridiales incertae sedis 186801|Clostridia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_300916_1 371042.NG99_23680 6.89e-54 183.0 COG2189@1|root,COG2189@2|Bacteria,1QUB9@1224|Proteobacteria,1RMSJ@1236|Gammaproteobacteria,3X6F2@551|Erwinia 1236|Gammaproteobacteria L DNA methylase - - 2.1.1.72 ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_179635_2 675635.Psed_5491 1.34e-23 100.0 COG2453@1|root,COG2453@2|Bacteria,2IHXA@201174|Actinobacteria,4E5XY@85010|Pseudonocardiales 201174|Actinobacteria T phosphatase - - - - - - - - - - - - Y_phosphatase k59_111738_1 556269.ACDQ01000003_gene1356 2.98e-20 95.9 COG4733@1|root,COG4733@2|Bacteria,1PG9M@1224|Proteobacteria,2W1MG@28216|Betaproteobacteria,4782D@75682|Oxalobacteraceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_368310_1 1198114.AciX9_1305 7.08e-34 129.0 COG3409@1|root,COG3409@2|Bacteria,3Y66V@57723|Acidobacteria 57723|Acidobacteria M PFAM Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Muraidase k59_247080_1 365046.Rta_33080 4.43e-20 92.8 COG3405@1|root,COG3405@2|Bacteria,1QZE5@1224|Proteobacteria,2W62R@28216|Betaproteobacteria,4AIQV@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - k59_72979_2 1165094.RINTHH_3920 5.4e-61 203.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_72979_4 1385658.U5KPZ6_9VIRU 1.83e-198 571.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_394980_1 1007104.SUS17_2099 5.17e-28 121.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TTEX@28211|Alphaproteobacteria,2K385@204457|Sphingomonadales 204457|Sphingomonadales S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_421621_1 1538804.A0A088F6T3_9CAUD 4.06e-16 80.1 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_421621_2 1484158.PSNIH1_00390 9.47e-18 85.1 2BMAA@1|root,32FU7@2|Bacteria,1Q0QX@1224|Proteobacteria,1TE0I@1236|Gammaproteobacteria,3W2IF@53335|Pantoea 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - HNH_3 k59_381017_2 1385658.U5KPZ6_9VIRU 2.75e-157 461.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_286953_1 1125971.ASJB01000064_gene6420 5.42e-26 108.0 COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,2I61A@201174|Actinobacteria 201174|Actinobacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - - k59_316131_1 234267.Acid_6881 3.59e-31 129.0 COG1361@1|root,COG3534@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3534@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria 2|Bacteria M PKD domain containing protein - - 3.4.21.50 ko:K01337,ko:K20276,ko:K21449 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Autotransporter,DUF4347,Glyco_hydro_43,He_PIG,P_proprotein,Peptidase_S8,TIG k59_179648_1 1215092.PA6_009_00130 7.32e-64 226.0 COG0454@1|root,COG0503@1|root,COG1040@1|root,COG0456@2|Bacteria,COG0503@2|Bacteria,COG1040@2|Bacteria,1QV41@1224|Proteobacteria,1SZB6@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis - - - - - - - - - - - - - k59_154469_15 765420.OSCT_0647 5.12e-16 76.3 COG0629@1|root,COG0629@2|Bacteria,2GAEV@200795|Chloroflexi,375UX@32061|Chloroflexia 32061|Chloroflexia L PFAM single-strand binding protein Primosomal replication protein n - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_181358_1 795359.TOPB45_0704 0.000115 52.4 COG1328@1|root,COG1372@1|root,COG1328@2|Bacteria,COG1372@2|Bacteria,2GH9B@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F ATP cone domain - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,Intein_splicing,NRDD k59_126428_1 76114.ebA3678 6.87e-13 67.8 COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,2VVT0@28216|Betaproteobacteria,2KXPG@206389|Rhodocyclales 206389|Rhodocyclales L Helix-hairpin-helix motif - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 k59_143117_1 186617.M9M8L2_9VIRU 6.73e-43 161.0 4QFNI@10239|Viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_75776_1 1548903.A0A0A1IWD4_9CAUD 8.91e-37 136.0 4QAUS@10239|Viruses,4QQ2S@28883|Caudovirales,4QHWP@10662|Myoviridae 10662|Myoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_33627_1 1234888.K0A2J2_9VIRU 8.59e-51 177.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_60024_1 470.IX87_04800 2.4e-36 130.0 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria,3NMIF@468|Moraxellaceae 1236|Gammaproteobacteria S Glycosyl hydrolase 108 - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_288688_2 266779.Meso_1199 4.93e-136 400.0 COG0553@1|root,COG0553@2|Bacteria,1R7CK@1224|Proteobacteria,2U228@28211|Alphaproteobacteria,43I7K@69277|Phyllobacteriaceae 28211|Alphaproteobacteria KL DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_100886_2 1265507.KB899636_gene1700 7.62e-05 43.9 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1Y4R5@135624|Aeromonadales 135624|Aeromonadales J A key translational regulator that binds mRNA to regulate translation initiation and or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'- UTR csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_318422_1 1121861.KB899943_gene3900 9.13e-07 59.7 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,2JPMC@204441|Rhodospirillales 204441|Rhodospirillales M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_233991_1 11082.PRO_0000037746 1.37e-246 716.0 4QBXT@10239|Viruses,4R138@439488|ssRNA viruses,4R0R1@35278|ssRNA positive-strand viruses no DNA stage 10239|Viruses K ATP-dependent helicase activity - GO:0001510,GO:0001959,GO:0001960,GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0003824,GO:0004482,GO:0004483,GO:0005488,GO:0005575,GO:0006139,GO:0006370,GO:0006396,GO:0006397,GO:0006508,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008171,GO:0008173,GO:0008174,GO:0008233,GO:0008757,GO:0009451,GO:0009452,GO:0009605,GO:0009607,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010648,GO:0010941,GO:0016032,GO:0016070,GO:0016071,GO:0016192,GO:0016556,GO:0016740,GO:0016741,GO:0016787,GO:0018995,GO:0019012,GO:0019031,GO:0019048,GO:0019049,GO:0019050,GO:0019054,GO:0019058,GO:0019065,GO:0019068,GO:0019219,GO:0019222,GO:0019538,GO:0020012,GO:0023051,GO:0023057,GO:0030260,GO:0030430,GO:0030682,GO:0030683,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031347,GO:0031348,GO:0032259,GO:0032991,GO:0032993,GO:0033592,GO:0033643,GO:0033646,GO:0033655,GO:0033668,GO:0034641,GO:0035821,GO:0036260,GO:0036265,GO:0036338,GO:0039502,GO:0039503,GO:0039526,GO:0039713,GO:0039714,GO:0042981,GO:0043067,GO:0043069,GO:0043170,GO:0043207,GO:0043412,GO:0043414,GO:0043487,GO:0043489,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044068,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044409,GO:0044413,GO:0044414,GO:0044415,GO:0044419,GO:0044423,GO:0044501,GO:0044531,GO:0044532,GO:0044766,GO:0045069,GO:0045070,GO:0045088,GO:0045824,GO:0045934,GO:0046483,GO:0046718,GO:0046755,GO:0046762,GO:0046794,GO:0048518,GO:0048519,GO:0048523,GO:0048524,GO:0048583,GO:0048585,GO:0050690,GO:0050776,GO:0050777,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051806,GO:0051807,GO:0051817,GO:0051828,GO:0051832,GO:0051833,GO:0051834,GO:0052027,GO:0052029,GO:0052031,GO:0052037,GO:0052040,GO:0052041,GO:0052150,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052248,GO:0052250,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052433,GO:0052490,GO:0052493,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060147,GO:0060149,GO:0060255,GO:0060338,GO:0060339,GO:0060548,GO:0060759,GO:0060761,GO:0060966,GO:0060967,GO:0060968,GO:0060969,GO:0065007,GO:0065008,GO:0071704,GO:0072583,GO:0075109,GO:0075111,GO:0075112,GO:0075114,GO:0075136,GO:0075509,GO:0075512,GO:0075528,GO:0080009,GO:0080090,GO:0080134,GO:0090304,GO:0097159,GO:0097617,GO:0098657,GO:0106005,GO:0140096,GO:0140098,GO:1900368,GO:1900369,GO:1901360,GO:1901363,GO:1901564,GO:1902369,GO:1902579,GO:1903900,GO:1903902,GO:1990814,GO:1990904 - - - - - - - - - - - k59_249090_4 69279.BG36_20875 5.16e-144 431.0 COG1783@1|root,COG4373@1|root,COG1783@2|Bacteria,COG4373@2|Bacteria,1PE12@1224|Proteobacteria,2V9EC@28211|Alphaproteobacteria,43QJZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Mu-like prophage FluMu protein gp28 - - - - - - - - - - - - - k59_423442_1 1410618.JNKI01000002_gene931 8.93e-36 132.0 COG4422@1|root,COG4422@2|Bacteria,1TPP1@1239|Firmicutes,4H3G7@909932|Negativicutes 909932|Negativicutes S Protein of unknown function (DUF5131) - - - - - - - - - - - - DUF5131 k59_250660_1 55601.VANGNB10_cI1548c 1.3e-15 81.6 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XSJE@135623|Vibrionales 135623|Vibrionales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_331446_1 1165094.RINTHH_3920 2.14e-28 111.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_21733_2 1268072.PSAB_06020 1.51e-12 67.8 COG0175@1|root,COG0175@2|Bacteria,1TQBQ@1239|Firmicutes,4HD3W@91061|Bacilli,270CN@186822|Paenibacillaceae 91061|Bacilli EH sulfate reduction - - - - - - - - - - - - - k59_371579_1 1340534.S4WXX3_9CAUD 1.31e-13 72.4 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales 28883|Caudovirales S HNH endonuclease - - - - - - - - - - - - - k59_221188_2 1692252.A0A0K1RL35_9CIRC 9.38e-64 206.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_412931_6 990285.RGCCGE502_22705 2.45e-40 170.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2U1H4@28211|Alphaproteobacteria,4BCD7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage-related minor tail protein - - - - - - - - - - - - Peptidase_M15_3,PhageMin_Tail k59_212258_1 345201.VF232_IIV3 7.58e-18 88.6 4QG9N@10239|Viruses,4QYPG@35237|dsDNA viruses no RNA stage 10239|Viruses K OTU-like cysteine protease - - - - - - - - - - - - - k59_212555_3 1206735.BAGG01000011_gene584 4.32e-24 102.0 COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria,4G2GK@85025|Nocardiaceae 201174|Actinobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_349462_5 1379698.RBG1_1C00001G1664 3.35e-18 84.3 COG1351@1|root,COG1351@2|Bacteria,2NPQ2@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_293528_1 1175654.A0A0S0NAE3_9CAUD 5.87e-26 112.0 4QB5I@10239|Viruses,4QWYV@35237|dsDNA viruses no RNA stage,4QTTK@28883|Caudovirales,4QM8X@10699|Siphoviridae 10699|Siphoviridae S ATP-dependent DNA helicase activity - - - - - - - - - - - - - k59_349464_1 1548905.A0A0A1IX16_9CAUD 4.59e-35 130.0 4QBTT@10239|Viruses,4QQUU@28883|Caudovirales,4QKWB@10699|Siphoviridae 10699|Siphoviridae S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - - k59_198650_1 756282.M4SPQ9_9CAUD 3.04e-05 53.9 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales,4QKRA@10699|Siphoviridae 10699|Siphoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_323594_4 63737.Npun_F1424 1.72e-18 100.0 COG2374@1|root,COG2931@1|root,COG3204@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,1GJET@1117|Cyanobacteria,1HRQ2@1161|Nostocales 1117|Cyanobacteria L Outer membrane adhesin like proteiin - - - ko:K07004 - - - - ko00000 - - - LTD k59_332845_5 1192034.CAP_4952 9.91e-07 55.1 COG3179@1|root,COG3409@1|root,COG3179@2|Bacteria,COG3409@2|Bacteria,1MYUR@1224|Proteobacteria,42UGP@68525|delta/epsilon subdivisions,2WWB8@28221|Deltaproteobacteria,2Z00D@29|Myxococcales 28221|Deltaproteobacteria M Chitinase class I - - - ko:K03791 - - - - ko00000 - GH19 - Glyco_hydro_19,LysM,PG_binding_1 k59_50553_2 1448389.BAVQ01000016_gene4044 4.91e-18 80.1 2AXAN@1|root,31P9R@2|Bacteria,2GZAI@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_373295_1 330214.NIDE3639 1.92e-85 285.0 COG1061@1|root,COG1061@2|Bacteria 2|Bacteria L Type III restriction enzyme res subunit sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Helicase_C,ResIII k59_63861_1 1385658.U5KPZ6_9VIRU 1.82e-57 194.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_198668_1 1537917.JU82_00020 1.09e-65 206.0 COG0553@1|root,COG0553@2|Bacteria,1PM15@1224|Proteobacteria,42ZGS@68525|delta/epsilon subdivisions,2YS8B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DEAD-like helicases superfamily - - - - - - - - - - - - - k59_185050_2 1463887.KL590004_gene1863 2.13e-05 53.5 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Beta_helix,Glyco_hydro_28,Pectate_lyase_3 k59_307481_2 1336803.PHEL49_2456 1.02e-25 96.3 COG1278@1|root,COG1278@2|Bacteria,4NURE@976|Bacteroidetes,1I50Z@117743|Flavobacteriia,3VWVB@52959|Polaribacter 976|Bacteroidetes K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_215374_2 883114.HMPREF9709_01052 1.06e-76 242.0 COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,249QG@186801|Clostridia,22GXR@1570339|Peptoniphilaceae 186801|Clostridia F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_171905_1 1609634.A0A0C5AFV4_9VIRU 2.12e-42 155.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_349799_2 1379717.S5SY19_9CIRC 1.29e-38 146.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_117300_2 1392501.JIAC01000001_gene1520 1.74e-13 75.5 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,4H2UC@909932|Negativicutes 909932|Negativicutes L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF2800 k59_267465_2 490913.C4NTF2_9CAUD 1.86e-47 162.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNX8@10744|Podoviridae 10744|Podoviridae S N-acetylmuramoyl-L-alanine amidase activity - GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0008150,GO:0008745,GO:0016032,GO:0016787,GO:0016810,GO:0016811,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0032897,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0043900,GO:0043901,GO:0043903,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0046782,GO:0048519,GO:0048525,GO:0050789,GO:0050792,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783,GO:0065007 - - - - - - - - - - - k59_375458_2 445686.E3SLJ5_9CAUD 1.35e-09 63.2 4QHN9@10239|Viruses,4QX1H@35237|dsDNA viruses no RNA stage,4QU3Z@28883|Caudovirales,4QJE6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_238918_2 343509.SG0727 1.06e-05 53.9 COG0270@1|root,COG0270@2|Bacteria,1NPQG@1224|Proteobacteria,1S07Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_66459_1 1238190.AMQY01000021_gene1570 7.19e-06 55.8 COG3170@1|root,COG3170@2|Bacteria,1R69E@1224|Proteobacteria 1224|Proteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_26654_2 3218.PP1S44_312V6.1 1.32e-24 104.0 2CM75@1|root,2QPHU@2759|Eukaryota,37NYC@33090|Viridiplantae,3G7BP@35493|Streptophyta 35493|Streptophyta - - - GO:0000003,GO:0000902,GO:0000904,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009653,GO:0009826,GO:0009846,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0016043,GO:0016049,GO:0022414,GO:0030154,GO:0032501,GO:0032502,GO:0032989,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0044706,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0051704,GO:0060560,GO:0071840 - - - - - - - - - - - k59_66464_2 318586.Pden_3765 3.86e-28 105.0 2D1MV@1|root,32TAZ@2|Bacteria,1N45A@1224|Proteobacteria,2UEJT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage protein (N4 Gp49/phage Sf6 gene 66) family - - - - - - - - - - - - Phage_gp49_66 k59_107273_1 1297863.APJF01000040_gene1790 0.000341 45.4 COG5281@1|root,COG5281@2|Bacteria,1R47M@1224|Proteobacteria,2TUIV@28211|Alphaproteobacteria,3JY6I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG5281, Phage-related minor tail protein - - - - - - - - - - - - - k59_134570_1 396588.Tgr7_1184 1.71e-65 214.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1WVX6@135613|Chromatiales 135613|Chromatiales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_282572_1 1235798.C817_04114 5.04e-47 166.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_226306_1 1327971.R9ZYK2_9CAUD 2.34e-53 179.0 4QCM7@10239|Viruses,4QVN1@35237|dsDNA viruses no RNA stage,4QPQ5@28883|Caudovirales 28883|Caudovirales S RNA ligase - - - - - - - - - - - - - k59_418450_2 1327977.S0A0N2_9CAUD 8.27e-45 166.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales 28883|Caudovirales S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_27593_1 1692252.A0A0K1RL35_9CIRC 7.9e-35 127.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_27593_3 1618238.A0A0C5IB41_9CIRC 9.27e-10 65.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_270265_1 46234.ANA_C12092 5.73e-110 320.0 COG2452@1|root,COG2452@2|Bacteria,1G6HY@1117|Cyanobacteria,1HPCQ@1161|Nostocales 1117|Cyanobacteria L Resolvase, N terminal domain - - - - - - - - - - - - MerR_1,Resolvase k59_270265_2 449447.MAE_33580 1.85e-56 190.0 COG0675@1|root,COG0675@2|Bacteria,1G3XF@1117|Cyanobacteria 1117|Cyanobacteria L Transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_256769_3 1618238.A0A0C5IB41_9CIRC 1.23e-19 95.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_189272_2 323848.Nmul_A1463 1.27e-89 285.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2VN61@28216|Betaproteobacteria,372UI@32003|Nitrosomonadales 28216|Betaproteobacteria S Phage terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_418468_2 691965.D4P7L6_9CAUD 9.47e-11 60.8 4QFKG@10239|Viruses,4QV77@35237|dsDNA viruses no RNA stage,4QR6Q@28883|Caudovirales,4QMGT@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_216293_1 1173762.S4TU76_9CAUD 3.9e-91 292.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_41214_2 1692252.A0A0K1RL35_9CIRC 5.14e-91 280.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_41214_3 1692242.A0A0K1RKZ2_9CIRC 3.09e-06 52.8 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_162458_1 1469607.KK073765_gene6586 1.94e-25 107.0 2CWXD@1|root,32T0J@2|Bacteria,1GAQJ@1117|Cyanobacteria,1HSA8@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_55006_1 33035.JPJF01000033_gene2261 0.000306 50.8 COG4675@1|root,COG4675@2|Bacteria,1UI0V@1239|Firmicutes,25E9P@186801|Clostridia 186801|Clostridia S tail collar domain protein - - - - - - - - - - - - - k59_311147_1 1128398.Curi_c03110 3.76e-08 62.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,267U0@186813|unclassified Clostridiales 186801|Clostridia L UvrD-like helicase C-terminal domain pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_175728_1 1173762.S4TNW6_9CAUD 1.54e-65 216.0 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_379491_1 1123020.AUIE01000007_gene3236 7.21e-50 177.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,1T44Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78,Phage_capsid k59_217196_1 1692257.A0A0K1RL39_9CIRC 6.16e-17 84.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_339588_1 716928.AJQT01000109_gene1217 1.52e-10 59.7 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1758_2 445686.E3SKU6_9CAUD 3.16e-06 49.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_177184_3 469371.Tbis_2182 2.1e-08 55.8 28YWQ@1|root,2ZKPU@2|Bacteria,2GZ6N@201174|Actinobacteria,4E7I4@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_230921_1 875454.BAEW01000002_gene465 5.04e-25 109.0 COG5281@1|root,COG5281@2|Bacteria,1TPWF@1239|Firmicutes,24A8R@186801|Clostridia 186801|Clostridia S tape measure - - - - - - - - - - - - - k59_109777_2 1357275.AVEL02000080_gene1713 1.59e-06 54.3 COG0640@1|root,COG0640@2|Bacteria,1R29M@1224|Proteobacteria,1T5K7@1236|Gammaproteobacteria,1ZADI@136849|Pseudomonas syringae group 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_204724_1 225117.XP_009366572.1 8.79e-11 61.2 2CV7H@1|root,2RRGK@2759|Eukaryota,383A9@33090|Viridiplantae,3GS0R@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_204724_2 7176.CPIJ015806-PA 1.68e-18 76.3 2DF3V@1|root,2S5RJ@2759|Eukaryota,3AARI@33154|Opisthokonta,3BTYV@33208|Metazoa,3DBCA@33213|Bilateria,421Q3@6656|Arthropoda 33208|Metazoa - - - - - - - - - - - - - - - k59_204724_3 7176.CPIJ008169-PA 4.86e-11 62.4 2E4T1@1|root,2SBN4@2759|Eukaryota,3ADG2@33154|Opisthokonta,3BWF0@33208|Metazoa,3DCTZ@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_366210_2 861208.AGROH133_06202 2.32e-28 117.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_230927_1 794903.OPIT5_27190 8.67e-33 129.0 COG1459@1|root,COG1459@2|Bacteria,46S8P@74201|Verrucomicrobia,3K7F2@414999|Opitutae 414999|Opitutae U type II secretion - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_326279_1 1117943.SFHH103_00150 2.97e-06 57.0 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria,4BP2Q@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_29186_1 313596.RB2501_01380 2.49e-40 142.0 2BVDA@1|root,32QTA@2|Bacteria,4NV3V@976|Bacteroidetes 976|Bacteroidetes S DNA-packaging protein gp3 - - - - - - - - - - - - GP3_package k59_29186_2 485918.Cpin_3882 2.51e-05 46.2 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_137333_1 1033737.CAEV01000029_gene296 2.36e-09 67.0 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,36H1A@31979|Clostridiaceae 186801|Clostridia S Phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_218544_2 1692250.A0A0K1RLR1_9CIRC 2.04e-58 196.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_165404_2 449673.BACSTE_02201 3e-116 346.0 COG0820@1|root,COG0820@2|Bacteria,4P8NE@976|Bacteroidetes,2FZPA@200643|Bacteroidia 976|Bacteroidetes H rRNA (adenine-C2-)-methyltransferase activity - - - - - - - - - - - - - k59_165404_3 716544.wcw_0668 3.06e-31 115.0 2E6PI@1|root,3319W@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_355306_2 622312.ROSEINA2194_03627 5.29e-23 103.0 28MKK@1|root,2ZAWR@2|Bacteria,1UYAT@1239|Firmicutes,24GI2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - RNA_helicase,Viral_Rep k59_300409_2 67275.JOAP01000059_gene1548 1.07e-14 77.8 COG0739@1|root,COG1652@1|root,COG0739@2|Bacteria,COG1652@2|Bacteria,2GK68@201174|Actinobacteria 201174|Actinobacteria M domain protein - - - ko:K21687 - - - - ko00000 - GH23 - LysM,Peptidase_M23,Transglycosylas k59_367951_2 1123242.JH636435_gene2431 8.58e-45 157.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_315534_1 1028806.GGE_2172 2.04e-13 79.3 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1SYI1@1236|Gammaproteobacteria 1236|Gammaproteobacteria D tape measure protein - - - - - - - - - - - - Phage_HK97_TLTM k59_408584_3 479434.Sthe_1157 3.59e-72 229.0 COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi,27XSM@189775|Thermomicrobia 189775|Thermomicrobia GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_300417_2 794903.OPIT5_03975 2.31e-13 68.6 2E653@1|root,330TW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_355320_1 321332.CYB_1341 3.6e-32 130.0 COG0438@1|root,COG0438@2|Bacteria,1G1WR@1117|Cyanobacteria,1H1UV@1129|Synechococcus 1117|Cyanobacteria M Glycosyl transferase, group 1 family protein - - - ko:K12993 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_315549_1 1692242.A0A0K1RKZ2_9CIRC 4.95e-44 158.0 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_218554_1 1463900.JOIX01000006_gene741 2.58e-41 152.0 COG1783@1|root,COG1783@2|Bacteria,2I8SC@201174|Actinobacteria 201174|Actinobacteria S Terminase-like family - - - - - - - - - - - - Terminase_3,Terminase_6,Terminase_6C k59_85411_2 1273707.L7TIC4_9CAUD 3.74e-36 127.0 4QFPC@10239|Viruses,4QXCG@35237|dsDNA viruses no RNA stage,4QPQC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_58087_2 1038860.AXAP01000067_gene8427 5.55e-26 108.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_44021_1 1537917.JU82_08840 1.25e-22 97.1 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family xkdG - - - - - - - - - - - Phage_capsid k59_273124_1 1038860.AXAP01000067_gene8427 2.03e-43 156.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_74846_1 1073999.BN137_2723 1.13e-31 129.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Type III restriction protein res subunit yejH GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042221,GO:0042493,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051301,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII k59_100142_2 379066.GAU_3762 0.000546 42.7 COG5295@1|root,COG5295@2|Bacteria 2|Bacteria UW Hep Hag repeat protein - - - - - - - - - - - - Peptidase_S74,YadA_head k59_302093_2 1234888.K0A2J2_9VIRU 1.27e-44 160.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_396037_1 266779.Meso_1200 5.31e-74 234.0 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria,2UJ12@28211|Alphaproteobacteria,43KMC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_357505_1 1481785.A0A068Q6G7_9CAUD 3.51e-12 73.9 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QNBW@10744|Podoviridae 10744|Podoviridae S DNA helicase activity - - - - - - - - - - - - - k59_45624_1 742740.HMPREF9474_02271 5.91e-75 239.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,221RR@1506553|Lachnoclostridium 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_45861_1 338963.Pcar_1822 4.06e-45 171.0 COG4643@1|root,COG4643@2|Bacteria,1QZ5M@1224|Proteobacteria 1224|Proteobacteria P DNA integration - - - - - - - - - - - - - k59_142642_1 314275.MADE_000001022515 5.7e-16 80.5 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_142642_3 1046625.AFQY01000003_gene2220 3.72e-24 97.1 2E6PI@1|root,3319W@2|Bacteria,1RCIK@1224|Proteobacteria,1S26P@1236|Gammaproteobacteria,3NP1S@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_209484_1 211165.AJLN01000060_gene3833 3.15e-22 101.0 COG1372@1|root,COG1372@2|Bacteria,1GKQ6@1117|Cyanobacteria,1JMJJ@1189|Stigonemataceae 1117|Cyanobacteria L Participates in initiation and elongation during chromosome replication - - - - - - - - - - - - - k59_5298_1 46234.ANA_C20636 5.73e-131 402.0 COG0286@1|root,COG0286@2|Bacteria,1G119@1117|Cyanobacteria,1HKJ8@1161|Nostocales 1117|Cyanobacteria V N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_422874_2 324057.Pjdr2_1769 1.85e-06 55.8 COG2931@1|root,COG3537@1|root,COG2931@2|Bacteria,COG3537@2|Bacteria,1UI05@1239|Firmicutes,4ISCK@91061|Bacilli,2771D@186822|Paenibacillaceae 91061|Bacilli Q Parallel beta-helix repeats - - - - - - - - - - - - - k59_264513_2 1237149.C900_05346 2.01e-35 127.0 COG1285@1|root,COG1285@2|Bacteria 2|Bacteria E pathogenesis mgtC GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0016020,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - ko:K07507 - - - - ko00000,ko02000 9.B.20 - iJN678.mgtC MgtC k59_424607_1 1465751.W8QN50_9VIRU 1.69e-111 326.0 4QFHB@10239|Viruses,4R0P6@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_346887_1 1123487.KB892865_gene1394 1.6e-44 159.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,2VMZW@28216|Betaproteobacteria 28216|Betaproteobacteria L DNA polymerase family A - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_35442_1 1266909.AUAG01000012_gene979 9.35e-06 53.9 COG0210@1|root,COG0210@2|Bacteria,1R4PV@1224|Proteobacteria,1RZXT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase - - - - - - - - - - - - AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2 k59_102602_1 1609634.A0A0C5AFV4_9VIRU 6.1e-84 266.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_290426_1 1232437.KL662018_gene583 1.16e-25 113.0 COG3378@1|root,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,42QNW@68525|delta/epsilon subdivisions,2X5R2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N k59_360704_1 1204521.I7A8M7_9CAUD 2.66e-98 315.0 4QCZC@10239|Viruses,4QX3V@35237|dsDNA viruses no RNA stage,4QRH3@28883|Caudovirales,4QHVR@10662|Myoviridae 10662|Myoviridae S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_61789_1 1788454.A0A190WHE4_9CIRC 6.1e-40 143.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_169233_1 1210884.HG799467_gene13131 1.51e-21 98.6 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_235577_1 1540098.A0A0A0RQI2_9CAUD 1.39e-88 283.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_196125_1 1134413.ANNK01000120_gene2048 9.32e-18 84.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - HNH_3 k59_21547_1 748727.CLJU_c03370 3.4e-35 137.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,36EZ3@31979|Clostridiaceae 186801|Clostridia L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_171439_1 59538.XP_005974585.1 4.94e-09 60.8 COG0209@1|root,COG1678@1|root,KOG1112@2759|Eukaryota,KOG1567@2759|Eukaryota,38B81@33154|Opisthokonta,3B9IQ@33208|Metazoa,3CUAM@33213|Bilateria,48345@7711|Chordata,48Y78@7742|Vertebrata,3JEFR@40674|Mammalia,4J4KZ@91561|Cetartiodactyla 33208|Metazoa F Ribonucleoside-diphosphate reductase large - - - - - - - - - - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_37593_2 1029823.AFIE01000007_gene1922 7.57e-54 184.0 COG5377@1|root,COG5377@2|Bacteria,1MWP8@1224|Proteobacteria,1RN9Q@1236|Gammaproteobacteria,3NIHJ@468|Moraxellaceae 1236|Gammaproteobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_426784_1 1121403.AUCV01000012_gene4123 3.58e-32 137.0 28K2M@1|root,2Z9RY@2|Bacteria,1R6RC@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - Beta_helix k59_373207_1 411460.RUMTOR_01339 4.64e-08 53.1 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_373207_2 742733.HMPREF9469_05026 1.13e-65 210.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia,221N8@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_222809_1 1220714.L7TNN0_9CAUD 1.23e-43 160.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_214861_1 1524880.A0A076G7N6_9VIRU 2.65e-42 167.0 4QAUF@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_116994_1 936580.HMPREF1516_0652 7.91e-24 106.0 COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,4HAR4@91061|Bacilli 91061|Bacilli M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_332782_1 1121405.dsmv_2337 3.54e-73 232.0 COG5549@1|root,COG5549@2|Bacteria,1R9BR@1224|Proteobacteria 1224|Proteobacteria O Belongs to the peptidase M12A family - - - - - - - - - - - - Astacin,PPC,Peptidase_M10 k59_104596_1 1386089.N865_13820 8.16e-53 185.0 COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria,4FEF7@85021|Intrasporangiaceae 201174|Actinobacteria S Alpha/beta-hydrolase family N-terminus - - - - - - - - - - - - Abhydrolase_9,Abhydrolase_9_N k59_92183_1 1088721.NSU_0775 6.39e-30 128.0 COG1196@1|root,COG1196@2|Bacteria,1R2A7@1224|Proteobacteria 1224|Proteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_171468_1 1327982.R9ZZE9_9CAUD 3.87e-98 301.0 4QGM3@10239|Viruses,4QYG4@35237|dsDNA viruses no RNA stage,4QPTC@28883|Caudovirales,4QMVS@10699|Siphoviridae 10699|Siphoviridae S oxidoreductase activity - - - - - - - - - - - - - k59_296595_1 1385658.U5KPZ6_9VIRU 6.87e-45 161.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_65972_3 1449976.KALB_4934 1.67e-10 60.8 2EC8I@1|root,30KXN@2|Bacteria,2HS8S@201174|Actinobacteria,4ECWQ@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_269566_1 479432.Sros_5523 1.26e-05 49.7 COG1051@1|root,COG1051@2|Bacteria,2IMF8@201174|Actinobacteria,4EK7I@85012|Streptosporangiales 201174|Actinobacteria F NUDIX domain - - - - - - - - - - - - NUDIX k59_309703_3 348824.LPU83_2009 3.89e-10 62.4 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,2UDZH@28211|Alphaproteobacteria,4BANK@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_106760_1 1506572.A0A097ZPG0_9CIRC 8.97e-34 132.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_238605_1 395495.Lcho_2188 2.02e-06 55.8 COG4643@1|root,COG4643@2|Bacteria,1QX3R@1224|Proteobacteria 1224|Proteobacteria L Zinc-binding domain of primase-helicase - - - - - - - - - - - - Prim_Zn_Ribbon,Toprim_3 k59_65984_4 1262528.L7TJ47_9VIRU 1.58e-16 76.6 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage 10239|Viruses S protein disulfide oxidoreductase activity - - - - - - - - - - - - - k59_26171_1 629265.PMA4326_05805 3.55e-14 76.6 2CC5E@1|root,3345H@2|Bacteria,1N69Q@1224|Proteobacteria,1SI2A@1236|Gammaproteobacteria,1Z9J8@136849|Pseudomonas syringae group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_26171_3 205918.Psyr_2827 4.16e-59 196.0 COG0175@1|root,COG0175@2|Bacteria,1PZ96@1224|Proteobacteria,1SBUC@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_310959_1 928210.CALU01000006_gene631 1.55e-13 75.5 COG3756@1|root,COG3756@2|Bacteria,1NQA5@1224|Proteobacteria,2UXA9@28211|Alphaproteobacteria,48UQM@772|Bartonellaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_270243_1 1226994.AMZB01000079_gene96 5.11e-10 69.7 2CZBU@1|root,32T60@2|Bacteria,1N7TC@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_324171_3 1354722.JQLS01000008_gene1449 1.31e-20 98.6 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2U2TT@28211|Alphaproteobacteria,46S2H@74030|Roseovarius 28211|Alphaproteobacteria OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_148867_1 196490.AUEZ01000004_gene3970 6.01e-23 102.0 COG2518@1|root,COG2518@2|Bacteria,1QW73@1224|Proteobacteria,2TWQQ@28211|Alphaproteobacteria,3K3AR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Domain of unknown function (DUF3560) - - - - - - - - - - - - DUF3560,MTS k59_418439_2 397290.C810_01958 7.35e-19 93.2 COG1961@1|root,COG1961@2|Bacteria,1TS5B@1239|Firmicutes,248MZ@186801|Clostridia,27RTP@186928|unclassified Lachnospiraceae 186801|Clostridia L Resolvase, N terminal domain - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_67968_1 35760.BCHO_0887 5.65e-12 72.4 2CHG1@1|root,32YZS@2|Bacteria,2IRMN@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_121761_1 1692249.A0A0K1RL40_9CIRC 1.56e-64 208.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_418445_3 1122201.AUAZ01000021_gene3152 1.19e-72 227.0 28W6R@1|root,2ZI7D@2|Bacteria,1N49N@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_81400_2 313596.RB2501_03785 1.82e-18 90.1 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,1HXMT@117743|Flavobacteriia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_388_106 1100721.ALKO01000021_gene753 5.29e-51 180.0 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,2VI3P@28216|Betaproteobacteria,4ABUA@80864|Comamonadaceae 28216|Betaproteobacteria L DNA ligase dnaL - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_388_107 1123052.AUDF01000002_gene611 3.35e-17 81.3 COG1451@1|root,COG1451@2|Bacteria,2I3WR@201174|Actinobacteria,4FNHP@85023|Microbacteriaceae 201174|Actinobacteria S SprT homologues. - - - - - - - - - - - - SprT-like k59_388_111 1493511.A0A0E3FRK0_9CAUD 5.31e-18 80.1 4QAZF@10239|Viruses,4QPH6@28883|Caudovirales,4QI08@10662|Myoviridae 10662|Myoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_388_115 443254.Marpi_0401 3.5e-134 404.0 COG2304@1|root,COG2304@2|Bacteria,2GE1P@200918|Thermotogae 200918|Thermotogae S Domain of unknown function (DUF2828) - - - - - - - - - - - - DUF2828 k59_388_122 946235.CAER01000066_gene2520 9.5e-41 143.0 COG4186@1|root,COG4186@2|Bacteria,1V35X@1239|Firmicutes,4IQV1@91061|Bacilli 91061|Bacilli S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_2 k59_388_124 1120980.JQKH01000022_gene1369 1.5e-36 144.0 COG0572@1|root,COG0639@1|root,COG0572@2|Bacteria,COG0639@2|Bacteria,1R7WI@1224|Proteobacteria,2VPBC@28216|Betaproteobacteria,2KQJJ@206351|Neisseriales 206351|Neisseriales FT Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - AAA_33,RNA_lig_T4_1,Zeta_toxin k59_388_125 1121943.KB899997_gene1719 6.19e-36 127.0 COG0645@1|root,COG0645@2|Bacteria,1N1S8@1224|Proteobacteria,1SEDC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - AAA_33 k59_285075_2 1385658.U5KNR1_9VIRU 9.12e-75 239.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_163493_1 1046714.AMRX01000006_gene3194 2.69e-23 104.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_29119_1 592015.HMPREF1705_02271 1.99e-21 93.6 COG1517@1|root,COG1517@2|Bacteria 2|Bacteria L CRISPR-associated protein, TM1812 family - - - ko:K19145 - - - - ko00000,ko02048 - - - Cas_DxTHG k59_29119_2 1175654.A0A0S0N767_9CAUD 6.36e-64 208.0 4QAUT@10239|Viruses,4QVIM@35237|dsDNA viruses no RNA stage,4QQ7X@28883|Caudovirales,4QKVS@10699|Siphoviridae 10699|Siphoviridae S DNA ligase (ATP) activity - - - - - - - - - - - - - k59_150371_1 553217.ENHAE0001_2188 1.68e-20 89.7 2CEI6@1|root,2ZED5@2|Bacteria,1RCK0@1224|Proteobacteria,1SJIE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_258199_1 575540.Isop_2434 8.17e-55 193.0 COG3087@1|root,COG3087@2|Bacteria,2IX3F@203682|Planctomycetes 203682|Planctomycetes D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_258199_2 575540.Isop_2435 1.89e-203 580.0 COG5511@1|root,COG5511@2|Bacteria,2IZFA@203682|Planctomycetes 203682|Planctomycetes S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_258199_5 1123508.JH636444_gene5330 1.15e-113 365.0 COG5525@1|root,COG5525@2|Bacteria,2IXN3@203682|Planctomycetes 203682|Planctomycetes S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_190681_1 547559.Nmag_0073 6.95e-12 70.9 COG1404@1|root,arCOG00702@2157|Archaea,2XT8S@28890|Euryarchaeota,23SZG@183963|Halobacteria 183963|Halobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 k59_230856_1 742740.HMPREF9474_02276 2.03e-29 108.0 2BD7A@1|root,326VE@2|Bacteria,1USRB@1239|Firmicutes,25ASG@186801|Clostridia,223BG@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_230856_3 411473.RUMCAL_00421 5.46e-29 112.0 COG4675@1|root,COG4675@2|Bacteria,1VDP2@1239|Firmicutes,24P8K@186801|Clostridia 186801|Clostridia S tail collar domain protein - - - - - - - - - - - - - k59_56284_1 105154.Q9MBT9_9VIRU 0.000828 42.0 4QCC5@10239|Viruses,4QUKW@29258|ssDNA viruses,4QP4C@10841|Microviridae 10841|Microviridae S viral process - - - - - - - - - - - - - k59_258416_1 1618237.A0A0C5IMG6_9CIRC 1.44e-23 104.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_258416_2 1379711.S5SYC9_9CIRC 5.4e-14 71.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_42554_4 1211643.K4JN71_9CAUD 1.08e-26 110.0 4QD1E@10239|Viruses,4QZVF@35237|dsDNA viruses no RNA stage,4QQTH@28883|Caudovirales,4QN2P@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_96517_1 1123377.AUIV01000006_gene1496 6.56e-34 124.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,1X4D2@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - VIT1 k59_163648_4 421052.F945_02500 0.00034 46.6 COG1876@1|root,COG1876@2|Bacteria 2|Bacteria M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_231006_1 1688.BCUN_0257 1.51e-35 151.0 COG3941@1|root,COG5412@1|root,COG3941@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,4CZ35@85004|Bifidobacteriales 201174|Actinobacteria S phage tail tape measure protein - - - - - - - - - - - - - k59_379678_1 260827.Q6R6B4_9CAUD 1.89e-53 186.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_96521_1 1527515.A0A088FB58_9CAUD 5.17e-33 140.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_72662_1 574087.Acear_1218 1.17e-42 145.0 arCOG06669@1|root,2ZC1E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_380716_1 1134912.AJTV01000005_gene778 8.97e-07 54.7 COG2227@1|root,COG2227@2|Bacteria,1MZ3S@1224|Proteobacteria,2UMAF@28211|Alphaproteobacteria,3714K@31993|Methylocystaceae 28211|Alphaproteobacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_23 k59_380716_2 1210884.HG799464_gene10460 1.24e-12 75.1 2DZS7@1|root,32VHJ@2|Bacteria 2|Bacteria S Glycosyltransferase sugar-binding region containing DXD motif - - - - - - - - - - - - Caps_synth k59_179066_1 359.CN09_11380 9.04e-18 83.6 28NEI@1|root,312GF@2|Bacteria,1PQPC@1224|Proteobacteria,2V31R@28211|Alphaproteobacteria,4BK0N@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_207058_1 1054213.HMPREF9946_02222 2.32e-24 114.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_315746_1 76869.PputGB1_1748 4.48e-29 120.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,1RZ7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_342320_1 1246626.BleG1_1649 1.85e-06 54.7 COG0258@1|root,COG0258@2|Bacteria,1UZU1@1239|Firmicutes,4HFKZ@91061|Bacilli,1ZBA7@1386|Bacillus 91061|Bacilli L Helix-hairpin-helix class 2 (Pol1 family) motifs - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N k59_98517_2 1348657.M622_18900 1.37e-36 128.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KWHT@206389|Rhodocyclales 206389|Rhodocyclales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_31289_1 1041142.ATTP01000021_gene187 3.56e-17 89.0 COG2268@1|root,COG2268@2|Bacteria,1NT13@1224|Proteobacteria,2U335@28211|Alphaproteobacteria,4BCZZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Band 7 protein - - - - - - - - - - - - - k59_140052_1 691965.D4P7C5_9CAUD 4.32e-136 402.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_140052_3 1493507.A0A0E3HQQ6_9CAUD 1.12e-08 65.5 4QFPG@10239|Viruses,4QWZI@35237|dsDNA viruses no RNA stage,4QS3K@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_140052_4 428125.CLOLEP_01407 2.58e-33 119.0 2DHA9@1|root,32U8X@2|Bacteria,1VD44@1239|Firmicutes,24NC3@186801|Clostridia,3WP9P@541000|Ruminococcaceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_140052_5 742733.HMPREF9469_05036 5.5e-50 163.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_140052_6 742733.HMPREF9469_05037 1.76e-27 103.0 2BD7A@1|root,326VE@2|Bacteria,1USRB@1239|Firmicutes,25ASG@186801|Clostridia,223BG@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_140052_7 935548.KI912159_gene1844 4.91e-25 110.0 COG3179@1|root,COG3409@1|root,COG3179@2|Bacteria,COG3409@2|Bacteria,1R71F@1224|Proteobacteria,2VF0B@28211|Alphaproteobacteria,43R6I@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Glyco_hydro_19,Peptidase_M15_4 k59_192470_1 401053.AciPR4_3094 5.56e-46 167.0 COG0270@1|root,COG0270@2|Bacteria,3Y5V5@57723|Acidobacteria,2JNSG@204432|Acidobacteriia 204432|Acidobacteriia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_192470_5 536233.CLO_1409 1.36e-25 116.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,24ESK@186801|Clostridia,36E7P@31979|Clostridiaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_111547_2 579138.Zymop_0823 8.94e-53 185.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,2K7D4@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_232335_1 1128421.JAGA01000002_gene1115 1.57e-46 168.0 COG5617@1|root,COG5617@2|Bacteria 2|Bacteria M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - PMT_2,PTPS_related k59_98532_2 105154.Q9MBU3_9VIRU 1.1e-11 69.3 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_58237_1 408672.NBCG_02054 1.67e-09 65.1 COG2519@1|root,COG2519@2|Bacteria 2|Bacteria J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA - - - ko:K13613 - - - - ko00000,ko01004,ko01008 - - - Methyltransf_21 k59_248422_1 1038860.AXAP01000067_gene8427 7.19e-43 158.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_369472_2 1348663.KCH_41940 9.57e-05 45.8 COG1061@1|root,COG1061@2|Bacteria,2GJ4Y@201174|Actinobacteria,2M3Z1@2063|Kitasatospora 201174|Actinobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,Mrr_cat,PLDc_2,ResIII k59_87412_1 1618248.A0A0C5IB82_9CIRC 4.02e-32 125.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_100401_1 2045.KR76_01825 3.49e-41 144.0 2DS48@1|root,33EFF@2|Bacteria,2H1FS@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_357732_1 941970.E7DUK7_9CAUD 7.71e-06 53.5 4QCM9@10239|Viruses,4QVZV@35237|dsDNA viruses no RNA stage,4QTYN@28883|Caudovirales,4QP2Y@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_87422_1 273068.TTE2069 7.54e-14 75.1 COG1475@1|root,COG1475@2|Bacteria,1V4KU@1239|Firmicutes,24IEQ@186801|Clostridia,42GN3@68295|Thermoanaerobacterales 186801|Clostridia K CHROMOSOME PARTITIONING PROTEIN PARB gi 11280351 pir D82035 ParB family protein VC2772 imported - Vibrio cholerae (group O1 strain N16961) gi 9657374 gb AAF95911.1 (AE004343) ParB family protein Vibrio cholerae , score - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_142597_1 1618259.A0A0C5I2B5_9CIRC 1.36e-57 191.0 4QE84@10239|Viruses,4QUKR@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_59724_1 373994.Riv7116_3794 6.3e-55 184.0 COG0302@1|root,COG0302@2|Bacteria,1G1K8@1117|Cyanobacteria,1HIXJ@1161|Nostocales 1117|Cyanobacteria H PFAM GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.folE,iJN678.folE GTP_cyclohydroI k59_396250_2 1353529.M899_2545 1.4e-15 80.5 2EGQU@1|root,33AGZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Collagen k59_396495_2 1219035.NT2_04_03350 1.5e-10 63.9 COG3773@1|root,COG3773@2|Bacteria,1RDSV@1224|Proteobacteria,2U8XY@28211|Alphaproteobacteria,2K4PG@204457|Sphingomonadales 204457|Sphingomonadales M COG3773 Cell wall hydrolyses involved in spore germination - - - - - - - - - - - - Hydrolase_2 k59_146094_1 1120966.AUBU01000006_gene3229 2.81e-61 216.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4NG54@976|Bacteroidetes,47MT2@768503|Cytophagia 976|Bacteroidetes D tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_412890_5 481448.Minf_0908 1.11e-36 147.0 COG0587@1|root,COG0587@2|Bacteria,46SG0@74201|Verrucomicrobia,37G41@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia L Bacterial DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_128717_2 948870.I7I014_9CAUD 2.46e-08 58.2 4QAUT@10239|Viruses,4QVIM@35237|dsDNA viruses no RNA stage,4QQ7X@28883|Caudovirales,4QIGV@10662|Myoviridae 10662|Myoviridae S DNA ligase (ATP) activity - - - - - - - - - - - - - k59_398487_1 1555208.A0A097EW24_9CAUD 2.67e-15 77.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_398487_2 666681.M301_0024 4.49e-10 63.9 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria 1224|Proteobacteria F Belongs to the dCTP deaminase family - - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - - k59_398487_3 1118057.CAGX01000043_gene511 3.28e-37 148.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,22GI8@1570339|Peptoniphilaceae 186801|Clostridia L DNA-directed DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_221337_1 648250.VNCS_JDNVP 1.32e-31 127.0 4QAUG@10239|Viruses,4QUM5@29258|ssDNA viruses 10239|Viruses L Parvovirus non-structural protein NS1 - GO:0001906,GO:0001907,GO:0005575,GO:0008150,GO:0009889,GO:0010556,GO:0010941,GO:0010942,GO:0016032,GO:0018995,GO:0019048,GO:0019051,GO:0019054,GO:0019056,GO:0019058,GO:0019079,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031341,GO:0031343,GO:0031640,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0035821,GO:0039526,GO:0039592,GO:0039656,GO:0039685,GO:0039693,GO:0042025,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044071,GO:0044215,GO:0044216,GO:0044217,GO:0044364,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0044533,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051726,GO:0051817,GO:0051818,GO:0051883,GO:0052026,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052312,GO:0052330,GO:0052433,GO:0052501,GO:0060139,GO:0060153,GO:0060255,GO:0065007,GO:0080090,GO:2001141 - - - - - - - - - - - k59_146471_1 1458724.W8G0W4_9CAUD 4.89e-09 62.8 4QB0J@10239|Viruses,4QZQE@35237|dsDNA viruses no RNA stage,4QQ11@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_90348_1 428125.CLOLEP_01409 1.68e-94 292.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_347226_1 582899.Hden_0147 9.4e-18 84.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2UIHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Pathogenesis-related transcriptional factor and ERF protein - - - - - - - - - - - - AP2,HNH_3 k59_21876_1 1165094.RINTHH_3920 3.76e-50 173.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_130812_1 1239962.C943_03282 4.45e-65 214.0 COG0270@1|root,COG0270@2|Bacteria,4NH5Z@976|Bacteroidetes 976|Bacteroidetes L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_323534_3 1370122.JHXQ01000018_gene66 7.4e-34 149.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2U1H4@28211|Alphaproteobacteria,4BCD7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage-related minor tail protein - - - - - - - - - - - - Peptidase_M15_3,PhageMin_Tail k59_323534_14 926569.ANT_19080 7.17e-05 53.1 COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi 200795|Chloroflexi L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_323534_16 744980.TRICHSKD4_0716 3.54e-34 135.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2TVMB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM Gp37Gp68 family protein - - - - - - - - - - - - DUF5131 k59_9671_1 679189.HMPREF9019_0945 2.33e-13 68.6 2EHJD@1|root,33BB9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_8 k59_9671_2 1236514.BAKL01000015_gene1638 2.96e-37 136.0 28KSZ@1|root,2ZAA8@2|Bacteria,4NHC3@976|Bacteroidetes,2FVKP@200643|Bacteroidia,4ASWA@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_278633_1 1005994.GTGU_01442 7.36e-33 130.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_307196_4 742767.HMPREF9456_03377 6.28e-31 120.0 COG1783@1|root,COG1783@2|Bacteria,4PN7V@976|Bacteroidetes,2G11J@200643|Bacteroidia,22YPN@171551|Porphyromonadaceae 976|Bacteroidetes S Terminase-like family - - - - - - - - - - - - Terminase_3,Terminase_6 k59_400256_1 485916.Dtox_3666 5.89e-45 157.0 COG4653@1|root,COG4653@2|Bacteria,1V4F0@1239|Firmicutes,24NSU@186801|Clostridia 186801|Clostridia S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_214962_1 51369.Q8LTA0_9CAUD 4.97e-08 58.5 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_9683_1 574376.BAMA_02055 1.21e-14 77.4 COG4983@1|root,COG5519@1|root,COG4983@2|Bacteria,COG5519@2|Bacteria,1TSFH@1239|Firmicutes,4HFH5@91061|Bacilli,1ZD36@1386|Bacillus 91061|Bacilli L Domain of unknown function (DUF927) - - - - - - - - - - - - DUF927 k59_293465_1 1262513.K7YIR2_9CAUD 6.8e-05 48.5 4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses no RNA stage,4QPCE@28883|Caudovirales,4QI56@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_92253_1 1038860.AXAP01000015_gene1972 7.53e-05 51.2 COG3598@1|root,COG3598@2|Bacteria,1R4EA@1224|Proteobacteria,2U8VM@28211|Alphaproteobacteria,3K08Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25,DnaB,Prim-Pol k59_363601_1 1556290.A0A0A0RSX5_9CAUD 5.99e-27 107.0 4QCAU@10239|Viruses,4QPJ6@28883|Caudovirales,4QKZJ@10699|Siphoviridae 10699|Siphoviridae S Pfam:GP88 - - - - - - - - - - - - - k59_307436_1 1234888.K0A2J2_9VIRU 3.44e-62 206.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_307436_6 1234888.K0A2J2_9VIRU 8.28e-98 302.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_374899_3 404589.Anae109_0078 1.19e-13 75.1 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2YTXF@29|Myxococcales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_40060_1 1028806.GGE_0147 8.56e-08 58.5 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1Y7ZN@135625|Pasteurellales 135625|Pasteurellales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_174442_2 863365.XHC_0796 0.000102 49.7 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,1X2Z2@135614|Xanthomonadales 135614|Xanthomonadales S Glycosyl transferase - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 k59_119161_1 457412.RSAG_01145 5.44e-41 149.0 COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia,3WNCM@541000|Ruminococcaceae 186801|Clostridia S Mu-like prophage protein gp29 - - - - - - - - - - - - - k59_106725_1 585.DR95_521 8.36e-46 151.0 COG4570@1|root,COG4570@2|Bacteria,1RH5J@1224|Proteobacteria,1S7I6@1236|Gammaproteobacteria,3Z3HB@583|Proteus 1236|Gammaproteobacteria L Endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_309692_2 1414738.V5UNX3_9CAUD 9.08e-123 380.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_53225_2 411460.RUMTOR_01358 3.3e-24 95.5 2CGGB@1|root,32UNH@2|Bacteria,1VD9W@1239|Firmicutes,24MWC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_53225_3 742733.HMPREF9469_05040 4.29e-28 107.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,221XY@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_119170_1 1401446.V6F7R7_9CAUD 6.61e-10 62.8 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QNBP@10744|Podoviridae 10744|Podoviridae S N-methyltransferase activity - - - - - - - - - - - - - k59_254918_2 1204521.I7B2R4_9CAUD 7.72e-63 202.0 4QF3X@10239|Viruses,4QWSV@35237|dsDNA viruses no RNA stage,4QT5P@28883|Caudovirales 28883|Caudovirales S oxidoreductase activity - - - - - - - - - - - - - k59_386741_2 428127.EUBDOL_00913 2.84e-12 74.7 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,3VPFM@526524|Erysipelotrichia 526524|Erysipelotrichia K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - HTH_3,ParBc k59_66245_2 744980.TRICHSKD4_0700 1.24e-54 182.0 COG3772@1|root,COG3772@2|Bacteria 2|Bacteria S cytolysis by virus of host cell - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_201862_1 1238450.VIBNISOn1_1100009 2.55e-09 60.5 COG0863@1|root,COG0863@2|Bacteria,1R7KV@1224|Proteobacteria,1RZ25@1236|Gammaproteobacteria,1XUTY@135623|Vibrionales 135623|Vibrionales L DNA methylase VP0394 - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_53661_1 1051675.G0YQG3_9CAUD 5.37e-52 176.0 4QEG2@10239|Viruses,4QVSD@35237|dsDNA viruses no RNA stage,4QRJ9@28883|Caudovirales,4QP0R@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_26437_1 1476876.JOJO01000002_gene6625 5.9e-47 163.0 COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria 2|Bacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_26437_2 1121405.dsmv_2652 0.000507 45.1 COG1874@1|root,COG3510@1|root,COG1874@2|Bacteria,COG3510@2|Bacteria 2|Bacteria V cephalosporin hydroxylase - - 3.2.1.23 ko:K01190,ko:K12308 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Cellulase,DUF4832,GHL6,Glyco_hydro_42,Glyco_hydro_42M,Methyltransf_24 k59_148498_1 107636.JQNK01000002_gene123 1.21e-18 95.9 COG4643@1|root,COG4643@2|Bacteria,1N08G@1224|Proteobacteria,2TV40@28211|Alphaproteobacteria,370E6@31993|Methylocystaceae 28211|Alphaproteobacteria L Protein of unknown function (DUF3987) - - - - - - - - - - - - DUF3987 k59_404745_1 749222.Nitsa_1373 1.82e-20 96.7 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2YMHD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_256339_6 1089547.KB913013_gene3945 4.48e-24 101.0 COG4675@1|root,COG4675@2|Bacteria,4NQJR@976|Bacteroidetes,47QBA@768503|Cytophagia 976|Bacteroidetes S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_202436_3 1898060.A0A1B2RVX4_9VIRU 8.55e-65 209.0 4QASH@10239|Viruses 10239|Viruses S Poxvirus A32 protein - - - - - - - - - - - - - k59_377995_2 742733.HMPREF9469_05024 5.14e-20 86.7 2ECB3@1|root,3369E@2|Bacteria,1VEV9@1239|Firmicutes,24R69@186801|Clostridia,223I2@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_13763_2 598659.NAMH_0676 1.52e-28 126.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YN3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_13763_4 1484460.JSWG01000009_gene633 1.82e-14 76.6 2E5T9@1|root,330HK@2|Bacteria,4NWGF@976|Bacteroidetes,1I5SC@117743|Flavobacteriia 976|Bacteroidetes S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_13763_6 411154.GFO_2444 2.72e-22 89.0 2EK2D@1|root,33DSU@2|Bacteria,4NXUE@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_229474_3 411473.RUMCAL_02615 1.26e-15 78.6 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WH0A@541000|Ruminococcaceae 186801|Clostridia L helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_418285_1 1391036.T1YRX6_9VIRU 3.45e-09 62.4 4QB6C@10239|Viruses 10239|Viruses L Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_189130_2 694569.D7S_00094 9.23e-60 202.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1S5J8@1236|Gammaproteobacteria,1Y79G@135625|Pasteurellales 135625|Pasteurellales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_148680_3 1172188.KB911820_gene2847 9.8e-82 265.0 COG3567@1|root,COG3567@2|Bacteria,2H48H@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_404978_1 1042375.AFPL01000026_gene3579 4.75e-12 62.4 COG4197@1|root,COG4197@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - - - - - - - - - - YdaS_antitoxin k59_27310_1 1175654.A0A0S0MVN0_9CAUD 5.24e-115 341.0 4QFED@10239|Viruses,4R072@35237|dsDNA viruses no RNA stage,4QPEH@28883|Caudovirales,4QN2V@10699|Siphoviridae 10699|Siphoviridae S tRNA modification - - - - - - - - - - - - - k59_27310_2 1538804.A0A088FAQ9_9CAUD 1.61e-98 300.0 4QFYS@10239|Viruses,4QUD0@28883|Caudovirales,4QMR9@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_109129_1 654929.REP_PCV1C 2.49e-14 78.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_379143_1 742740.HMPREF9474_02267 6.43e-23 95.1 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia,221N8@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_365543_1 1414738.V5UQL8_9CAUD 1.63e-97 310.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_14681_1 156978.CIMIT_05645 1.09e-27 115.0 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,22MAR@1653|Corynebacteriaceae 201174|Actinobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_122840_2 944547.ABLL_0523 8.46e-21 94.4 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2YMGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_109298_1 1123288.SOV_2c10440 7.1e-145 424.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4H2V4@909932|Negativicutes 909932|Negativicutes KL DEAD-like helicases superfamily - - - - - - - - - - - - N6_N4_Mtase k59_176721_3 1732201.A0A0N9N7I3_9CIRC 1.31e-09 65.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_95931_1 68219.JNXI01000031_gene5502 3.73e-49 182.0 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_204034_2 1121285.AUFK01000002_gene40 7.86e-16 79.7 29D2S@1|root,3000U@2|Bacteria,4PGQF@976|Bacteroidetes,1IM4Y@117743|Flavobacteriia,3ZSNA@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_69366_2 1416009.V9VG06_9CAUD 7.41e-47 166.0 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QNDS@10744|Podoviridae 10744|Podoviridae S ATPase activity - - - - - - - - - - - - - k59_109307_1 393595.ABO_0437 2.04e-06 48.5 COG4696@1|root,COG4696@2|Bacteria,1N92T@1224|Proteobacteria,1SVFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - PRA-PH k59_109307_2 521674.Plim_0989 4.62e-36 141.0 COG0714@1|root,COG4643@1|root,COG0714@2|Bacteria,COG4643@2|Bacteria,2J0Z2@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF3987) - - - - - - - - - - - - DUF3987 k59_14893_2 114615.BRADO2879 1.12e-08 59.7 COG2520@1|root,COG2520@2|Bacteria,1RIYU@1224|Proteobacteria,2U2ZF@28211|Alphaproteobacteria,3JSC4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_314282_2 909663.KI867149_gene3310 1.61e-06 58.9 2DGZ9@1|root,2ZXUN@2|Bacteria,1PGYB@1224|Proteobacteria,432NE@68525|delta/epsilon subdivisions,2WYC6@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_84248_2 742740.HMPREF9474_02279 2.81e-47 157.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,221XY@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_30115_1 1235811.HMPREF0653_02348 7.65e-27 109.0 COG0270@1|root,COG0270@2|Bacteria,4NRFG@976|Bacteroidetes,2FWKI@200643|Bacteroidia 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_354197_1 1391428.V5KSA4_9CAUD 9.45e-41 144.0 4QE8Z@10239|Viruses,4QVDS@35237|dsDNA viruses no RNA stage,4QSJE@28883|Caudovirales,4QJX1@10662|Myoviridae 10662|Myoviridae S methyltransferase activity - - - - - - - - - - - - - k59_393788_1 227470.Q76YS7_9CAUD 5.81e-23 102.0 4QC5J@10239|Viruses,4QXP7@35237|dsDNA viruses no RNA stage,4QTBX@28883|Caudovirales,4QJQT@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF2828) - - - - - - - - - - - - - k59_285960_1 1121441.AUCX01000005_gene1263 2.26e-16 77.4 2DPB2@1|root,331BY@2|Bacteria,1NBDA@1224|Proteobacteria,42VNW@68525|delta/epsilon subdivisions,2WSXY@28221|Deltaproteobacteria,2MDC1@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_138479_1 1329516.JPST01000011_gene358 1.64e-08 57.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,4HHQR@91061|Bacilli 91061|Bacilli H C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_110643_1 1232410.KI421417_gene2756 8.55e-14 79.0 2DZHM@1|root,32VAY@2|Bacteria,1N0DC@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_151145_10 709991.Odosp_2632 3.39e-22 112.0 COG5185@1|root,COG5283@1|root,COG5185@2|Bacteria,COG5283@2|Bacteria 2|Bacteria D Phage-related minor tail protein - - 3.2.1.18 ko:K01186,ko:K21471,ko:K22051 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko01002,ko01011,ko02000,ko02042 1.A.23.1.2,1.A.23.1.3 GH33 - PhageMin_Tail k59_151145_12 673862.BABL1_707 0.000356 55.1 COG1520@1|root,COG2706@1|root,COG1520@2|Bacteria,COG2706@2|Bacteria,1QV8R@1224|Proteobacteria 1224|Proteobacteria G 6-phosphogluconolactonase activity - - - ko:K20952 ko05111,map05111 - - - ko00000,ko00001 - - - Beta-prism_lec,DUF4347,HYR,VCBS k59_151145_15 1041826.FCOL_05415 4.09e-12 76.3 COG0616@1|root,COG0616@2|Bacteria,4NTQT@976|Bacteroidetes,1I4CV@117743|Flavobacteriia,2NY17@237|Flavobacterium 976|Bacteroidetes OU COG0616 Periplasmic serine proteases (ClpP class) - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_380276_8 93059.P9211_11951 1.51e-28 109.0 2AMM7@1|root,31CH8@2|Bacteria,1GIN8@1117|Cyanobacteria,1MMG4@1212|Prochloraceae 1117|Cyanobacteria L Pyrimidine dimer DNA glycosylase - - 3.1.25.1 ko:K01161 - - - - ko00000,ko01000 - - - Pyr_excise k59_4499_1 1227266.HMPREF1551_00551 8.71e-64 216.0 COG0553@1|root,COG0553@2|Bacteria,4PPQ7@976|Bacteroidetes 976|Bacteroidetes KL Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair - - - - - - - - - - - - - k59_316964_3 1505227.A0A076GAF9_9CAUD 5.46e-50 160.0 4QGQX@10239|Viruses,4QQ2D@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_208366_1 1089545.KB913037_gene5102 8.12e-21 92.0 COG0500@1|root,COG0500@2|Bacteria,2GMXG@201174|Actinobacteria,4DX79@85010|Pseudonocardiales 201174|Actinobacteria Q C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_208366_2 1455075.W6PN91_9CAUD 1.8e-06 53.5 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_166493_1 294631.Q5ZGD4_9CAUD 7.82e-39 158.0 4QB2X@10239|Viruses,4QXYM@35237|dsDNA viruses no RNA stage,4QRYM@28883|Caudovirales,4QMB2@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_356645_1 1233488.S4T7V3_9CAUD 4.17e-82 270.0 4QEDJ@10239|Viruses,4QZ5Q@35237|dsDNA viruses no RNA stage,4QPM4@28883|Caudovirales,4QP27@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_356645_3 5872.XP_004829874.1 2.6e-25 119.0 COG0349@1|root,COG0749@1|root,KOG2373@1|root,KOG0950@2759|Eukaryota,KOG2206@2759|Eukaryota,KOG2373@2759|Eukaryota,3YBAR@5794|Apicomplexa,3KA43@422676|Aconoidasida,3Z42K@5863|Piroplasmida 422676|Aconoidasida JL DNA polymerase I - GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7,3.6.4.12 ko:K02335,ko:K17680 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03029,ko03032,ko03400 - - - AAA_25,DNA_pol_A,DNA_pol_A_exo1 k59_356645_5 1244856.K4PWR8_9CAUD 1.14e-83 258.0 4QBA2@10239|Viruses,4QV98@35237|dsDNA viruses no RNA stage,4QPPI@28883|Caudovirales,4QP1B@10744|Podoviridae 10744|Podoviridae S Thymidylate synthase - - - - - - - - - - - - - k59_356645_7 760011.Spico_1311 2.01e-17 80.9 COG2131@1|root,COG2131@2|Bacteria,2J6UR@203691|Spirochaetes 203691|Spirochaetes F Cytidine and deoxycytidylate deaminase zinc-binding region - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_356645_8 1244856.K4PW80_9CAUD 1.66e-73 233.0 4QHME@10239|Viruses,4QXRV@35237|dsDNA viruses no RNA stage,4QQUH@28883|Caudovirales,4QNND@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_356645_9 1244856.K4PWS0_9CAUD 1.46e-151 441.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QNNC@10744|Podoviridae 10744|Podoviridae S N-methyltransferase activity - - - - - - - - - - - - - k59_356645_10 1357279.N018_16280 6.92e-09 65.1 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,1RQ06@1236|Gammaproteobacteria,1Z9K4@136849|Pseudomonas syringae group 1236|Gammaproteobacteria L DNA polymerase Ligase (LigD) ligD - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_356645_13 1233488.S4T7Z9_9CAUD 2.98e-59 218.0 4QG3G@10239|Viruses,4R03C@35237|dsDNA viruses no RNA stage,4QPZ8@28883|Caudovirales,4QNW8@10744|Podoviridae 10744|Podoviridae S catalytic activity - - - - - - - - - - - - - k59_141701_2 523845.AQXV01000055_gene108 3.37e-11 73.6 COG2425@1|root,arCOG00442@2157|Archaea,2Y0II@28890|Euryarchaeota,23RFT@183939|Methanococci 183939|Methanococci S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_141701_5 1118054.CAGW01000012_gene4003 3.17e-05 54.3 COG0714@1|root,COG0714@2|Bacteria,1UXAG@1239|Firmicutes,4HC1E@91061|Bacilli,26VTC@186822|Paenibacillaceae 91061|Bacilli S AAA domain (dynein-related subfamily) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5 k59_74335_1 1121015.N789_14675 0.000188 47.4 2AJ3C@1|root,319MR@2|Bacteria,1QFH1@1224|Proteobacteria,1TCRJ@1236|Gammaproteobacteria,1X9QJ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_301738_2 1249627.D779_3920 1.22e-05 52.8 COG0419@1|root,COG1196@1|root,COG5281@1|root,COG0419@2|Bacteria,COG1196@2|Bacteria,COG5281@2|Bacteria,1RM55@1224|Proteobacteria,1SB8T@1236|Gammaproteobacteria,1X0YE@135613|Chromatiales 135613|Chromatiales DL Prophage tail length tape measure protein - - - - - - - - - - - - - k59_395680_1 338966.Ppro_3564 1.18e-07 63.5 COG0467@1|root,COG0467@2|Bacteria,1R9I6@1224|Proteobacteria 1224|Proteobacteria T AAA domain - - - - - - - - - - - - AAA_25,PriCT_2,Prim-Pol k59_208685_2 479433.Caci_3017 5.38e-11 63.9 2DPAY@1|root,331AT@2|Bacteria,2GSM7@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - ASCH k59_289609_3 29875.EHK19034 7.24e-05 51.6 2EEPU@1|root,2SK24@2759|Eukaryota,39XQC@33154|Opisthokonta,3NXM7@4751|Fungi,3QM42@4890|Ascomycota,2117A@147550|Sordariomycetes,3TKIC@5125|Hypocreales 4751|Fungi S Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_412166_1 1217715.F994_02783 9.98e-18 80.9 2D1MV@1|root,32TAZ@2|Bacteria,1N45A@1224|Proteobacteria,1S954@1236|Gammaproteobacteria,3NNB4@468|Moraxellaceae 1236|Gammaproteobacteria S Phage protein (N4 Gp49/phage Sf6 gene 66) family - - - - - - - - - - - - DUF2829,Phage_gp49_66 k59_264210_2 1416760.AYMS01000142_gene640 5.04e-139 451.0 COG1196@1|root,COG1196@2|Bacteria,4NUKP@976|Bacteroidetes,1I4MA@117743|Flavobacteriia 976|Bacteroidetes D nuclear chromosome segregation - - - - - - - - - - - - - k59_168779_1 278957.ABEA03000110_gene1319 2.64e-16 86.7 COG0270@1|root,COG0270@2|Bacteria,46XFY@74201|Verrucomicrobia,3K9VN@414999|Opitutae 414999|Opitutae L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_412172_2 642492.Clole_0798 9.08e-11 64.7 COG3935@1|root,COG3935@2|Bacteria,1V6IW@1239|Firmicutes,24FSU@186801|Clostridia 186801|Clostridia L Domain of unknown function (DUF4373) - - - - - - - - - - - - DUF4373,DnaB_2 k59_346163_2 1692244.A0A0K1RLR5_9CIRC 2.14e-31 120.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_412181_1 292414.TM1040_0821 1.21e-17 90.9 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K12287 - - - - ko00000,ko02044 - - - DUF11,VCBS k59_89436_3 931276.Cspa_c11140 0.000389 41.2 COG2155@1|root,COG2155@2|Bacteria,1VEQJ@1239|Firmicutes,24QKW@186801|Clostridia,36MUX@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF378) - - - ko:K09779 - - - - ko00000 - - - DUF378 k59_346173_1 1692253.A0A0K1RLM4_9CIRC 2.94e-14 73.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_306695_2 68223.JNZY01000009_gene3131 1.13e-67 226.0 COG1215@1|root,COG4627@1|root,COG1215@2|Bacteria,COG4627@2|Bacteria,2IAZU@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,Methyltransf_11 k59_63396_1 439235.Dalk_1042 1.09e-13 76.6 COG1216@1|root,COG4122@1|root,COG1216@2|Bacteria,COG4122@2|Bacteria,1N2AR@1224|Proteobacteria,42R09@68525|delta/epsilon subdivisions,2WMWB@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_63396_2 472759.Nhal_0383 2.76e-20 97.1 COG0438@1|root,COG1196@1|root,COG4641@1|root,COG0438@2|Bacteria,COG1196@2|Bacteria,COG4641@2|Bacteria 2|Bacteria M Protein conserved in bacteria CP_0732 - - ko:K05802,ko:K13000 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 1.A.23.1.1 GT4 - Cu_amine_oxidN1,Glyco_trans_1_2 k59_91769_1 1397278.AYMV01000022_gene2044 8.36e-33 136.0 COG4932@1|root,COG4932@2|Bacteria,2GXWA@201174|Actinobacteria,4FNFZ@85023|Microbacteriaceae 201174|Actinobacteria M domain protein - - - - - - - - - - - - CarboxypepD_reg,SASA k59_23391_1 718252.FP2_16210 1.78e-52 174.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,3WGVE@541000|Ruminococcaceae 186801|Clostridia V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_214247_1 1247726.MIM_c14740 2.2e-19 97.4 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,3T32Z@506|Alcaligenaceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_372863_4 1123278.KB893397_gene5348 3.77e-59 190.0 COG1961@1|root,COG1961@2|Bacteria,4NNTC@976|Bacteroidetes,47QFD@768503|Cytophagia 976|Bacteroidetes L Resolvase, N terminal domain - - - - - - - - - - - - Resolvase k59_332500_2 1537917.JU82_06570 2.43e-49 164.0 2CGG9@1|root,2ZVSJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_332500_3 691965.D4P7D9_9CAUD 9.37e-87 265.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_332500_4 691965.D4P7D8_9CAUD 7.19e-33 117.0 4QBBW@10239|Viruses,4QXCP@35237|dsDNA viruses no RNA stage,4QQ3N@28883|Caudovirales,4QN1X@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_23668_1 64363.EME49284 1.72e-06 48.9 2D2VG@1|root,2SP6A@2759|Eukaryota,39YSU@33154|Opisthokonta,3P156@4751|Fungi,3QSHG@4890|Ascomycota,200JN@147541|Dothideomycetes,3MNDH@451867|Dothideomycetidae 4751|Fungi S Protein of unknown function (DUF2945) - - - - - - - - - - - - DUF2945 k59_23668_3 1197951.I6S295_9CAUD 4.32e-37 127.0 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_332703_1 445974.CLORAM_02245 4.1e-50 183.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,3VNZB@526524|Erysipelotrichia 526524|Erysipelotrichia G Psort location Cytoplasmic, score ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_296365_2 908337.HMPREF9257_0553 5.31e-14 71.2 COG1694@1|root,COG1694@2|Bacteria,1VFER@1239|Firmicutes,4HM4N@91061|Bacilli,27F1I@186827|Aerococcaceae 91061|Bacilli S Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG,PRA-PH k59_11772_1 888743.HMPREF9141_0984 1.17e-05 53.5 2EVUA@1|root,33P81@2|Bacteria,4P82D@976|Bacteroidetes,2FV68@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_296367_1 1515615.HQ41_08855 1.17e-20 86.3 COG0720@1|root,COG0720@2|Bacteria,4PIUG@976|Bacteroidetes,2FSF1@200643|Bacteroidia,22Z05@171551|Porphyromonadaceae 976|Bacteroidetes H 6-pyruvoyl tetrahydrobiopterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_296367_2 1538804.A0A088F7Y4_9CAUD 1.39e-28 111.0 4QH75@10239|Viruses,4QQZ4@28883|Caudovirales,4QKSF@10699|Siphoviridae 10699|Siphoviridae S GTP cyclohydrolase I activity - - - - - - - - - - - - - k59_174151_1 1120999.JONM01000015_gene2918 1.92e-19 99.8 COG3391@1|root,COG4625@1|root,COG3391@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria 28216|Betaproteobacteria MU TIGRFAM outer membrane autotransporter barrel domain protein - - - - - - - - - - - - Autotransporter,He_PIG,TIG k59_309500_3 1358423.N180_02870 2.43e-10 63.2 2DEUM@1|root,2ZPBE@2|Bacteria,4P78P@976|Bacteroidetes,1IZYU@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_12186_2 1300005.R9RG79_9CAUD 1.13e-25 112.0 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_334856_2 697281.Mahau_1836 3.53e-61 206.0 COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales 186801|Clostridia G TIGRFAM bifunctional phosphoglucose phosphomannose isomerase - - 5.3.1.8,5.3.1.9 ko:K15916 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R01819,R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - SIS,bact-PGI_C k59_40225_2 314275.MADE_000001022565 2.86e-11 67.0 2F37P@1|root,33W26@2|Bacteria,1NW0J@1224|Proteobacteria,1SP1F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_269713_2 575540.Isop_2434 5.77e-35 136.0 COG3087@1|root,COG3087@2|Bacteria,2IX3F@203682|Planctomycetes 203682|Planctomycetes D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_429011_4 653733.Selin_1736 4.42e-23 103.0 COG0568@1|root,COG0568@2|Bacteria 2|Bacteria K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoS - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_26282_1 391038.Bphy_1919 6.44e-30 114.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,1KAW7@119060|Burkholderiaceae 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_162153_1 663278.Ethha_2190 4.27e-36 144.0 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WJQ5@541000|Ruminococcaceae 186801|Clostridia M Cysteine-rich secretory protein family - - - - - - - - - - - - CAP,LysM k59_256705_2 1122201.AUAZ01000010_gene2520 1.02e-43 153.0 29UKS@1|root,30FY7@2|Bacteria,1RGKW@1224|Proteobacteria,1SKMS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_391587_1 1233488.S4T7V3_9CAUD 2.47e-62 216.0 4QEDJ@10239|Viruses,4QZ5Q@35237|dsDNA viruses no RNA stage,4QPM4@28883|Caudovirales,4QP27@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_351287_1 1070319.CAGGBEG34_900002 2.14e-41 145.0 COG4384@1|root,COG4384@2|Bacteria,1RASK@1224|Proteobacteria,2WFY9@28216|Betaproteobacteria,1K7TT@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage baseplate assembly protein V - - - - - - - - - - - - Phage_Mu_Gp45 k59_351287_2 882.DVU_2852 3.27e-13 67.8 COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,430E3@68525|delta/epsilon subdivisions,2WVTH@28221|Deltaproteobacteria,2MCQV@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage protein GP46 - - - - - - - - - - - - GP46 k59_148904_1 555088.DealDRAFT_2961 3.93e-27 112.0 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,42JNG@68298|Syntrophomonadaceae 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_418478_1 1286171.EAL2_c19880 5.75e-13 69.7 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,25VCN@186806|Eubacteriaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_216298_2 1298880.AUEV01000015_gene81 2.47e-11 66.6 COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria 201174|Actinobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_94968_2 69279.BG36_11250 1.14e-66 223.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,43K5X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_135367_2 1007869.M9MUW6_9CAUD 9.02e-10 65.9 4QDKP@10239|Viruses,4QZHT@35237|dsDNA viruses no RNA stage,4QTRD@28883|Caudovirales,4QJJC@10662|Myoviridae 10662|Myoviridae S transaminase activity - - - - - - - - - - - - - k59_135367_6 313606.M23134_06477 8.26e-85 273.0 COG1783@1|root,COG1783@2|Bacteria,4NSZ4@976|Bacteroidetes,47P61@768503|Cytophagia 976|Bacteroidetes S phage Terminase large subunit - - - - - - - - - - - - - k59_162313_3 1305737.JAFX01000001_gene2604 2.37e-05 48.5 COG3628@1|root,COG3628@2|Bacteria,4NSKN@976|Bacteroidetes 976|Bacteroidetes S Phage baseplate assembly protein W - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_216302_1 1232443.BAIA02000103_gene2909 6.22e-35 128.0 COG0175@1|root,COG0175@2|Bacteria,1UZK3@1239|Firmicutes,24CWM@186801|Clostridia,26AVI@186813|unclassified Clostridiales 186801|Clostridia EH Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_324217_1 521000.PROVRETT_05970 1.19e-50 169.0 28IQ7@1|root,2Z8PY@2|Bacteria,1NA66@1224|Proteobacteria,1S212@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RecT family bet - - - - - - - - - - - RecT k59_339651_1 691965.D4P7D6_9CAUD 1.58e-89 286.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_42367_1 293644.Q5IGW9_9CAUD 1.78e-22 98.2 4QC2T@10239|Viruses,4QWRA@35237|dsDNA viruses no RNA stage,4QPRB@28883|Caudovirales,4QN2R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_406643_1 1392502.JNIO01000008_gene1414 1.23e-11 69.7 COG0463@1|root,COG0463@2|Bacteria,1UN61@1239|Firmicutes,4H9JT@909932|Negativicutes 1239|Firmicutes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_271377_2 7209.EJD76673.1 1.09e-08 65.5 28KVY@1|root,2RXKG@2759|Eukaryota,39ZUR@33154|Opisthokonta,3BPP5@33208|Metazoa,3D6YG@33213|Bilateria,40CXF@6231|Nematoda,1KVIZ@119089|Chromadorea 33208|Metazoa S Bacterial protein of unknown function (HtrL_YibB) - - - - - - - - - - - - HtrL_YibB k59_271377_3 234267.Acid_0568 7.79e-51 190.0 COG2192@1|root,COG2192@2|Bacteria,3Y37V@57723|Acidobacteria 57723|Acidobacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_271377_8 313606.M23134_02132 3.8e-16 91.3 COG3227@1|root,COG4733@1|root,COG3227@2|Bacteria,COG4733@2|Bacteria,4NF8H@976|Bacteroidetes,47MX4@768503|Cytophagia 976|Bacteroidetes E Thermolysin metallopeptidase, catalytic domain npr - 3.4.24.28 ko:K01400 - - - - ko00000,ko01000,ko01002 - - - FTP,MAM,PepSY,Peptidase_M4,Peptidase_M4_C,fn3 k59_419775_5 439292.Bsel_3009 4.64e-67 239.0 COG3780@1|root,COG4626@1|root,COG3780@2|Bacteria,COG4626@2|Bacteria,1TPU1@1239|Firmicutes,4HAXI@91061|Bacilli,26PJM@186821|Sporolactobacillaceae 91061|Bacilli L Phage Terminase - - - - - - - - - - - - Terminase_1 k59_163483_1 204773.HEAR2273 5.63e-50 170.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2WBUY@28216|Betaproteobacteria,477U0@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_419778_3 1134413.ANNK01000120_gene2048 2.17e-22 93.6 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - HNH_3 k59_217263_1 90371.CY43_10715 9.26e-14 75.9 COG0640@1|root,COG3756@1|root,COG0640@2|Bacteria,COG3756@2|Bacteria,1N0B6@1224|Proteobacteria,1S9GJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_190669_1 396595.TK90_1231 5.86e-15 79.3 COG3756@1|root,COG3756@2|Bacteria,1QW2K@1224|Proteobacteria,1S1C7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_177103_3 1234888.K0A2J2_9VIRU 1.25e-77 252.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_137221_1 935948.KE386495_gene1689 1.83e-09 63.5 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42FJ3@68295|Thermoanaerobacterales 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_352983_2 1122931.AUAE01000005_gene3258 1.89e-47 190.0 2EAST@1|root,334US@2|Bacteria,4NRGD@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_244951_2 40523.A8ASX2_BPA51 9.81e-15 78.2 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QI32@10662|Myoviridae 10662|Myoviridae S DNA polymerase family A - - - - - - - - - - - - - k59_163629_1 665956.HMPREF1032_03268 7.9e-06 52.8 2EG1N@1|root,339TN@2|Bacteria 2|Bacteria S prophage protein Bartonella henselae str. Houston-1 gi 49237922 emb CAF27125.1 - - - - - - - - - - - - PTR k59_163629_2 1121889.AUDM01000003_gene2226 2.45e-08 65.9 COG4733@1|root,COG4733@2|Bacteria,4PKY7@976|Bacteroidetes,1IJH4@117743|Flavobacteriia,2P0QU@237|Flavobacterium 976|Bacteroidetes L Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - MAM,Reprolysin_4,fn3 k59_272651_2 749222.Nitsa_0531 3.94e-32 124.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,42NNI@68525|delta/epsilon subdivisions,2YNBH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25,Methyltransf_31 k59_272651_14 469660.A8HNV9_9CAUD 1.15e-60 230.0 4QBTM@10239|Viruses,4QWCV@35237|dsDNA viruses no RNA stage,4QRTG@28883|Caudovirales,4QNB6@10744|Podoviridae 10744|Podoviridae S Methyltransferase small domain - - - - - - - - - - - - - k59_124521_1 313596.RB2501_02025 0.000704 48.5 COG3210@1|root,COG3210@2|Bacteria,4PKI0@976|Bacteroidetes,1HYWF@117743|Flavobacteriia 976|Bacteroidetes U PFAM Collagen triple helix repeat (20 copies) - - - - - - - - - - - - Collagen k59_178739_1 886882.PPSC2_p0165 2.07e-13 74.3 COG0739@1|root,COG0739@2|Bacteria,1UKQQ@1239|Firmicutes,4ITX0@91061|Bacilli 91061|Bacilli M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_206553_1 1304883.KI912532_gene120 3.83e-60 201.0 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,2VISI@28216|Betaproteobacteria,2KXZI@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_139245_1 488538.SAR116_0377 8.78e-47 163.0 COG4373@1|root,COG4373@2|Bacteria 2|Bacteria - - gp17a - - ko:K06909 - - - - ko00000 - - - Terminase_6,Terminase_6C k59_84977_2 388051.AUFE01000035_gene4020 2.35e-07 58.2 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_354870_2 350054.Mflv_2925 1.19e-05 45.8 COG3311@1|root,COG3311@2|Bacteria,2GSWD@201174|Actinobacteria,23BFE@1762|Mycobacteriaceae 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_17 k59_341741_1 394.NGR_c19040 3.64e-57 196.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,2U1P9@28211|Alphaproteobacteria,4BDQ9@82115|Rhizobiaceae 28211|Alphaproteobacteria S DNA packaging protein gp2 - - - - - - - - - - - - Terminase_6,Terminase_6C k59_124528_1 691965.D4P7D6_9CAUD 1.89e-53 195.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_206557_1 1125863.JAFN01000001_gene3546 7.47e-181 529.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,42MCU@68525|delta/epsilon subdivisions,2WJ3Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_341751_1 1574422.A0A0A1ENW9_9CIRC 1.81e-22 98.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_30786_1 1150621.SMUL_1878 2.91e-07 57.0 COG0494@1|root,COG0494@2|Bacteria,1N9TV@1224|Proteobacteria,43395@68525|delta/epsilon subdivisions,2YSIH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_394520_2 1540097.A0A0A0YUA7_9CAUD 4.16e-65 209.0 4QGM6@10239|Viruses,4QRH4@28883|Caudovirales,4QP0P@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_43860_6 653733.Selin_1470 1.17e-31 116.0 COG0629@1|root,COG0629@2|Bacteria 2|Bacteria L single-stranded DNA binding ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_43860_9 1200352.A606_11755 9.23e-25 114.0 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,22K4C@1653|Corynebacteriaceae 201174|Actinobacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_43860_12 1266909.AUAG01000006_gene2454 1.5e-18 87.8 293XU@1|root,2ZRCV@2|Bacteria,1PBKB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_43860_34 1215915.BN193_08560 5.43e-07 60.8 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli,1YB98@1357|Lactococcus 91061|Bacilli E metallopeptidase activity radC - - ko:K03630 - - - - ko00000 - - - RadC k59_112689_1 1234888.K0A2J2_9VIRU 1.49e-50 179.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_261835_1 945713.IALB_0073 3.72e-44 167.0 COG3941@1|root,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - - k59_219299_3 1158604.I591_00099 0.000605 45.8 COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1UPJ7@1239|Firmicutes,4HBA7@91061|Bacilli,4B0U2@81852|Enterococcaceae 91061|Bacilli G Glyco_18 chiB - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - CBM_2,CBM_5_12,DUF5011,Glyco_hydro_18,fn3 k59_112694_1 1121895.Q765_03190 2.01e-18 88.6 COG0467@1|root,COG0467@2|Bacteria,4PK66@976|Bacteroidetes,1INEQ@117743|Flavobacteriia,2NZBJ@237|Flavobacterium 976|Bacteroidetes T Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - - - - - - - - - - - k59_317457_1 1415778.JQMM01000001_gene317 2.7e-170 520.0 COG0823@1|root,COG0823@2|Bacteria,1R4CN@1224|Proteobacteria,1S0NH@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40 k59_142279_3 563192.HMPREF0179_02963 3.41e-10 64.3 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - ko:K03529 - - - - ko00000,ko03036 - - - PhageMin_Tail,Tape_meas_lam_C k59_193853_1 571.MC52_18290 1.44e-25 110.0 COG3096@1|root,COG5281@1|root,COG3096@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1RS2K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M tape measure protein - - - - - - - - - - - - Phage_HK97_TLTM k59_288190_1 1500894.JQNN01000001_gene4022 3.12e-12 70.1 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,472I3@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_302098_3 1121456.ATVA01000014_gene632 2.69e-88 286.0 COG1783@1|root,COG1783@2|Bacteria,1RAGC@1224|Proteobacteria,42Z29@68525|delta/epsilon subdivisions,2WTUP@28221|Deltaproteobacteria,2MCJK@213115|Desulfovibrionales 28221|Deltaproteobacteria S phage Terminase large subunit - - - - - - - - - - - - - k59_302098_4 745411.B3C1_01460 3.54e-51 174.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Muraidase,PG_binding_1 k59_302098_6 1008459.TASI_0441 7.8e-66 237.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_59595_1 1121930.AQXG01000005_gene747 6.1e-65 210.0 COG0809@1|root,COG0809@2|Bacteria,4NF2T@976|Bacteroidetes,1INNG@117747|Sphingobacteriia 976|Bacteroidetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) - - - - - - - - - - - - Queuosine_synth k59_422678_4 744980.TRICHSKD4_2531 3.13e-12 79.0 COG3087@1|root,COG3087@2|Bacteria,1QU07@1224|Proteobacteria,2TR07@28211|Alphaproteobacteria 28211|Alphaproteobacteria D peptidase U35 phage prohead HK97 u35 - - - - - - - - - - - Mu-like_gpT,Peptidase_S78 k59_274320_3 292414.TM1040_0792 2.63e-21 92.0 COG0827@1|root,COG0827@2|Bacteria,1N8I1@1224|Proteobacteria,2UIBZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA restriction-modification system - - - - - - - - - - - - - k59_274320_6 1161931.J7F8X6_9CAUD 1.79e-97 307.0 4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses no RNA stage,4QR8A@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_19038_1 1167632.AJTR01000043_gene2333 1.77e-05 55.5 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4HA1S@91061|Bacilli,4GX4M@90964|Staphylococcaceae 91061|Bacilli D Belongs to the FtsK SpoIIIE SftA family sftA - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE,Ftsk_gamma k59_250142_1 1370122.JHXQ01000018_gene66 8.21e-51 199.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2U1H4@28211|Alphaproteobacteria,4BCD7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage-related minor tail protein - - - - - - - - - - - - Peptidase_M15_3,PhageMin_Tail k59_331001_4 411460.RUMTOR_01381 5.99e-32 123.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_89636_1 1125725.HMPREF1325_1312 7.2e-09 55.8 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_220709_1 265729.GS18_0205840 8.96e-47 167.0 2EYIP@1|root,33RSF@2|Bacteria,1VSNU@1239|Firmicutes,4HUJ1@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_114611_5 1484157.PSNIH2_21345 7.96e-33 126.0 COG4262@1|root,COG4262@2|Bacteria,1QFYV@1224|Proteobacteria,1TDAF@1236|Gammaproteobacteria,3W1N9@53335|Pantoea 1236|Gammaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_182542_1 1123288.SOV_2c10440 1.33e-85 269.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4H2V4@909932|Negativicutes 909932|Negativicutes KL DEAD-like helicases superfamily - - - - - - - - - - - - N6_N4_Mtase k59_397834_1 420246.GTNG_3417 1.24e-56 193.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H9Y8@91061|Bacilli,1WFN6@129337|Geobacillus 91061|Bacilli L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_383235_1 1122176.KB903532_gene2635 3.59e-42 147.0 COG0860@1|root,COG0860@2|Bacteria,4NR00@976|Bacteroidetes 976|Bacteroidetes M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_304522_1 1192868.CAIU01000008_gene927 4.7e-38 145.0 COG1783@1|root,COG1783@2|Bacteria,1PE12@1224|Proteobacteria,2V9EC@28211|Alphaproteobacteria,43QJZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Mu-like prophage FluMu protein gp28 - - - - - - - - - - - - - k59_49853_1 469610.HMPREF0189_01174 1.85e-16 86.3 COG0305@1|root,COG0305@2|Bacteria,1PP51@1224|Proteobacteria,2VQ9Z@28216|Betaproteobacteria 28216|Betaproteobacteria L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C k59_348614_1 1085623.GNIT_1811 2.1e-37 137.0 COG0073@1|root,COG0073@2|Bacteria 2|Bacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890,ko:K06878 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind k59_322898_1 1082931.KKY_1760 7.78e-46 158.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,3N6QJ@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_322898_2 1358423.N180_02820 8.9e-10 61.2 2E8S0@1|root,3332X@2|Bacteria,4NWIA@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_322898_3 86416.Clopa_1892 9.66e-23 107.0 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,248E9@186801|Clostridia,36EE3@31979|Clostridiaceae 186801|Clostridia L Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_171040_1 1463853.JOHW01000002_gene5809 2.35e-20 96.3 COG1595@1|root,COG2340@1|root,COG1595@2|Bacteria,COG2340@2|Bacteria,2GJ21@201174|Actinobacteria 201174|Actinobacteria K belongs to the sigma-70 factor family - - - - - - - - - - - - CAP,Sigma70_r2 k59_278277_1 1327970.R9ZXR7_9CAUD 6.08e-61 198.0 4QAXN@10239|Viruses,4QVNW@35237|dsDNA viruses no RNA stage,4QPV1@28883|Caudovirales,4QM0D@10699|Siphoviridae 10699|Siphoviridae S D12 class N6 adenine-specific DNA methyltransferase - - - - - - - - - - - - - k59_278277_2 675635.Psed_2831 2.61e-08 57.8 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DZKF@85010|Pseudonocardiales 201174|Actinobacteria L DNA polymerase III alpha subunit dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_399967_1 1465751.W8QF08_9VIRU 1.19e-99 308.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage 10239|Viruses S Ribonucleotide reductase, barrel domain - GO:0001959,GO:0001960,GO:0003674,GO:0003824,GO:0004748,GO:0005575,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0010646,GO:0010648,GO:0010803,GO:0010804,GO:0016491,GO:0016725,GO:0016728,GO:0018995,GO:0023051,GO:0023057,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0055114,GO:0060759,GO:0060761,GO:0061731,GO:0065007 - - - - - - - - - - - k59_23498_1 1150626.PHAMO_80087 1.54e-35 145.0 COG3941@1|root,COG3941@2|Bacteria,1PHQP@1224|Proteobacteria,2V9RW@28211|Alphaproteobacteria,2JWSI@204441|Rhodospirillales 204441|Rhodospirillales S Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Tape_meas_lam_C k59_161474_1 1392540.P256_00055 1e-91 289.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1RMTH@1236|Gammaproteobacteria,3NMJ9@468|Moraxellaceae 1236|Gammaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_402264_1 1158165.KB898873_gene414 1.87e-05 47.0 COG5377@1|root,COG5377@2|Bacteria,1QXFN@1224|Proteobacteria,1RR25@1236|Gammaproteobacteria,1WXAP@135613|Chromatiales 135613|Chromatiales L PFAM YqaJ viral recombinase family - - - - - - - - - - - - YqaJ k59_269476_2 655097.C8ZKC9_9CAUD 1.38e-06 53.5 4QEPU@10239|Viruses,4QWA2@35237|dsDNA viruses no RNA stage,4QQ3T@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_238529_2 1205910.B005_2760 2e-11 70.5 COG5412@1|root,COG5412@2|Bacteria,2HEJI@201174|Actinobacteria,4EQCZ@85012|Streptosporangiales 201174|Actinobacteria S Phage tail tape measure protein TP901 - - - - - - - - - - - - - k59_65896_1 457421.CBFG_01546 9.05e-09 65.9 COG5362@1|root,COG5362@2|Bacteria,1TSQB@1239|Firmicutes,24ACE@186801|Clostridia,26AI9@186813|unclassified Clostridiales 186801|Clostridia S TIGRFAM Phage - - - - - - - - - - - - - k59_174377_2 1458357.BG58_11025 6.4e-22 94.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,1KAW7@119060|Burkholderiaceae 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_201401_1 1234888.K0A2J2_9VIRU 2.27e-35 137.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_334653_1 697281.Mahau_2914 3.58e-69 241.0 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,42FVH@68295|Thermoanaerobacterales 186801|Clostridia S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_Mu_F,Phage_portal k59_133854_3 979533.F1D0V0_9CAUD 3.85e-91 292.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_386499_1 313606.M23134_00256 1.49e-24 105.0 COG3864@1|root,COG3864@2|Bacteria,4NZN2@976|Bacteroidetes 976|Bacteroidetes S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_106693_5 1121937.AUHJ01000007_gene1934 2.13e-47 161.0 2DICG@1|root,302RI@2|Bacteria,1PVSB@1224|Proteobacteria,1STCY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_68027_19 1476888.X4Y7Z1_9CAUD 1.32e-22 101.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_68027_21 478749.BRYFOR_08514 1.99e-39 135.0 2ARVA@1|root,31H70@2|Bacteria,1V7JT@1239|Firmicutes,24JPE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - HK97-gp10_like k59_68027_22 478749.BRYFOR_08513 1.86e-87 325.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Amidase_2,LysM,PG_binding_1 k59_311108_1 1548905.A0A0A1IUL8_9CAUD 5.45e-19 88.2 4QBA2@10239|Viruses,4QPPI@28883|Caudovirales,4QM0B@10699|Siphoviridae 10699|Siphoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_311108_2 378806.STAUR_5975 4.49e-16 85.5 28HY4@1|root,2Z83J@2|Bacteria,1Q1KZ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_81600_2 455632.SGR_3347 5.62e-51 171.0 COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria,41CRY@629295|Streptomyces griseus group 201174|Actinobacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_378610_2 186617.M9M8L2_9VIRU 9.86e-26 110.0 4QFNI@10239|Viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_189537_2 572265.HDEF_1700 1.89e-47 158.0 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,1S6D5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase M15 - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_391962_1 1121124.JNIX01000011_gene1668 1.54e-15 78.6 2EGT2@1|root,33AJ6@2|Bacteria,1NKSD@1224|Proteobacteria,2UYHD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_418690_1 1321784.HMPREF1987_02197 1.41e-06 58.9 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia 186801|Clostridia D Peptidase, M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_418690_4 1120933.ATUY01000010_gene1534 1.03e-33 123.0 COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4D497@85005|Actinomycetales 201174|Actinobacteria L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_351520_1 1540091.A0A0A0RV67_9CAUD 2.74e-12 68.2 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_162561_1 196164.23493480 8.17e-18 85.9 COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,22KRQ@1653|Corynebacteriaceae 201174|Actinobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_270463_1 1304872.JAGC01000009_gene749 4.47e-26 119.0 COG4842@1|root,COG4842@2|Bacteria 2|Bacteria S protein secretion by the type VII secretion system - - - - - - - - - - - - WXG100 k59_55153_2 935839.JAGJ01000032_gene29 9.46e-50 188.0 COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4F412@85017|Promicromonosporaceae 201174|Actinobacteria L Type III restriction enzyme, res subunit sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - ResIII k59_137804_15 1122135.KB893163_gene454 7.39e-33 136.0 COG0286@1|root,COG0286@2|Bacteria 2|Bacteria V site-specific DNA-methyltransferase (adenine-specific) activity - - - - - - - - - - - - DUF4376,HsdM_N,MTS,N6_Mtase k59_123531_1 1173762.S4TT67_9CAUD 3.64e-61 202.0 4QCT5@10239|Viruses,4QYJH@35237|dsDNA viruses no RNA stage,4QTPG@28883|Caudovirales,4QNK2@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_123531_2 1173762.S4TNV6_9CAUD 7.6e-15 74.3 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_56709_1 387092.NIS_0450 7.75e-17 79.7 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,42XCR@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_313604_1 1283071.R9R4C5_9CAUD 6.16e-10 60.8 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae S N-acetyltransferase activity - - - - - - - - - - - - - k59_138081_1 1206545.S6C3A9_9CAUD 1.75e-07 51.2 4QFW3@10239|Viruses,4R0GR@35237|dsDNA viruses no RNA stage,4QS8R@28883|Caudovirales,4QI0I@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_138081_2 1328029.S0A5K4_9CAUD 2.35e-45 163.0 4QBG0@10239|Viruses,4QWYZ@35237|dsDNA viruses no RNA stage,4QSGM@28883|Caudovirales,4QP2Q@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_205455_1 172088.AUGA01000082_gene6217 3.35e-13 73.6 COG3740@1|root,COG3740@2|Bacteria,1NBQ9@1224|Proteobacteria,2UK6T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_340519_1 1234664.AMRO01000024_gene1812 1.64e-08 56.6 2DP09@1|root,3300D@2|Bacteria,1VHDB@1239|Firmicutes,4HXIA@91061|Bacilli,1WH4G@129337|Geobacillus 91061|Bacilli S Bacteriophage HK97-gp10, putative tail-component - - - - - - - - - - - - HK97-gp10_like k59_43031_4 1331060.RLDS_03865 4.18e-37 137.0 2CMPB@1|root,32SF8@2|Bacteria,1RCNY@1224|Proteobacteria,2UPH0@28211|Alphaproteobacteria,2K2QJ@204457|Sphingomonadales 204457|Sphingomonadales S Transcription elongation protein SprT - - - - - - - - - - - - - k59_71048_1 44689.DDB0232268 4.55e-67 232.0 COG0417@1|root,KOG0969@2759|Eukaryota,3X854@554915|Amoebozoa 554915|Amoebozoa L DNA polymerase - GO:0000228,GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006287,GO:0006289,GO:0006297,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0030894,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0043601,GO:0043625,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02327 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko05166,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map05166 M00262 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,zf-C4pol k59_71048_2 78898.MVEG_12380T0 3.36e-08 63.5 COG0417@1|root,KOG0969@2759|Eukaryota,38DSD@33154|Opisthokonta,3NUXQ@4751|Fungi,1GT0T@112252|Fungi incertae sedis 4751|Fungi L DNA polymerase family B - - - - - - - - - - - - DNA_pol_B k59_166018_1 1073754.G0ZNE5_9VIRU 3.43e-27 108.0 4QAIU@10239|Viruses 10239|Viruses S HNH endonuclease - - - - - - - - - - - - - k59_73252_1 1227266.HMPREF1551_00550 4.02e-117 342.0 COG0863@1|root,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,1I7WE@117743|Flavobacteriia,1EQNF@1016|Capnocytophaga 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_421739_1 755732.Fluta_2976 2.76e-49 166.0 COG3409@1|root,COG3409@2|Bacteria,4NTD1@976|Bacteroidetes 976|Bacteroidetes M Peptidoglycan binding domain protein - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_368464_1 883114.HMPREF9709_01688 2.2e-63 219.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,22GE3@1570339|Peptoniphilaceae 186801|Clostridia F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN k59_73276_1 1536769.P40081_28560 3.22e-28 124.0 COG4626@1|root,COG4626@2|Bacteria,1TPU1@1239|Firmicutes,4HAXI@91061|Bacilli,26UM1@186822|Paenibacillaceae 91061|Bacilli S Terminase - - - - - - - - - - - - Terminase_1 k59_140636_1 1385658.U5KNR1_9VIRU 1.2e-52 182.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_140636_3 1385658.U5KPZ6_9VIRU 2.68e-173 504.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_140636_4 105154.Q9MBU3_9VIRU 2.87e-09 63.2 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_409167_2 1122137.AQXF01000002_gene208 6.05e-19 84.0 2E645@1|root,330T3@2|Bacteria,1NEGX@1224|Proteobacteria,2UJTA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_409167_6 948071.S4S2D9_9CAUD 4.68e-171 501.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_140638_2 764595.G9B208_9CAUD 2.46e-24 100.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_330425_1 1282362.AEAC466_21405 9.32e-07 56.2 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,2KEZW@204458|Caulobacterales 204458|Caulobacterales M Cytidylyltransferase kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_382716_3 1072685.IX83_07155 9.15e-18 76.3 2EJST@1|root,33DHF@2|Bacteria 2|Bacteria S Helix-turn-helix domain - - - - - - - - - - - - HTH_39 k59_382716_4 55601.VANGNB10_cI1625c 7.18e-08 55.8 COG1802@1|root,COG1802@2|Bacteria,1QV8Z@1224|Proteobacteria,1T2AF@1236|Gammaproteobacteria,1XYCZ@135623|Vibrionales 135623|Vibrionales K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_181960_1 1609634.A0A0C5AFV4_9VIRU 1.08e-84 270.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_113973_1 428125.CLOLEP_01417 4.12e-29 113.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,3WMXK@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_144106_1 634956.Geoth_2375 2.51e-19 92.0 COG1277@1|root,COG1277@2|Bacteria,1V1P1@1239|Firmicutes,4HCZ3@91061|Bacilli,1WFU0@129337|Geobacillus 91061|Bacilli S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_144106_2 1385520.N802_06500 5.38e-104 309.0 COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4FF61@85021|Intrasporangiaceae 201174|Actinobacteria V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_127038_1 665956.HMPREF1032_00665 3.1e-45 166.0 28JED@1|root,2Z98K@2|Bacteria,1TW1U@1239|Firmicutes,24CFD@186801|Clostridia,3WNW0@541000|Ruminococcaceae 186801|Clostridia K Bacterial regulatory proteins, luxR family - - - - - - - - - - - - GerE k59_359524_1 880070.Cycma_2359 8.84e-107 325.0 COG3378@1|root,COG3378@2|Bacteria,4NG1J@976|Bacteroidetes,47P0B@768503|Cytophagia 976|Bacteroidetes S TIGRFAM phage plasmid primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_359524_2 1185876.BN8_04844 2.36e-13 73.2 COG0358@1|root,COG0358@2|Bacteria,4NEFU@976|Bacteroidetes,47Q6Q@768503|Cytophagia 976|Bacteroidetes L COG NOG08810 non supervised orthologous group - - - - - - - - - - - - - k59_20608_1 1385658.U5KPZ6_9VIRU 6.43e-139 412.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_424067_1 1286632.P278_33640 2.15e-124 354.0 28HGS@1|root,2Z7SJ@2|Bacteria,4NERU@976|Bacteroidetes,1HZIZ@117743|Flavobacteriia 976|Bacteroidetes S Major spike protein (G protein) - - - - - - - - - - - - Phage_G k59_424067_2 1270196.JCKI01000013_gene3205 0.0 889.0 28IN7@1|root,2Z8NM@2|Bacteria,4NHTH@976|Bacteroidetes 976|Bacteroidetes S Capsid protein (F protein) - - - - - - - - - - - - Phage_F k59_424067_3 1286632.P278_33670 1.35e-19 79.0 2EFW9@1|root,339NJ@2|Bacteria,4P71N@976|Bacteroidetes,1I6VT@117743|Flavobacteriia 976|Bacteroidetes S Microvirus J protein - - - - - - - - - - - - Microvir_J k59_424067_4 1288298.rosmuc_01661 4.9e-103 298.0 28HVF@1|root,2Z81Q@2|Bacteria,1NZPF@1224|Proteobacteria 1224|Proteobacteria S Bacteriophage scaffolding protein D - - - - - - - - - - - - gpD k59_424067_5 1270196.JCKI01000013_gene3202 4.42e-56 174.0 2AGWD@1|root,3174S@2|Bacteria 2|Bacteria S Phage protein C - - - - - - - - - - - - Phage_C k59_424067_6 1286632.P278_33700 0.0 1035.0 28I9J@1|root,2Z8C8@2|Bacteria,4P06R@976|Bacteroidetes,1I7XB@117743|Flavobacteriia 976|Bacteroidetes S Bacteriophage replication gene A protein (GPA) - - - - - - - - - - - - Phage_GPA k59_424067_7 1288298.rosmuc_01659 6.62e-188 527.0 2DBBW@1|root,2Z8AR@2|Bacteria,1R492@1224|Proteobacteria,2UP8C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Microvirus H protein (pilot protein) - - - - - - - - - - - - Microvir_H k59_359525_2 536019.Mesop_5384 5.2e-08 63.5 COG1215@1|root,COG1215@2|Bacteria,1R66B@1224|Proteobacteria,2U968@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_319600_1 345201.VF232_IIV3 1.33e-40 159.0 4QG9N@10239|Viruses,4QYPG@35237|dsDNA viruses no RNA stage 10239|Viruses K OTU-like cysteine protease - - - - - - - - - - - - - k59_370748_2 1054460.SPPN_00145 0.000528 47.4 2CWXD@1|root,32T0J@2|Bacteria,1V83I@1239|Firmicutes,4HPQE@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_135067_2 862751.SACTE_0428 2.45e-05 45.8 COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria 201174|Actinobacteria L Uracil-DNA glycosylase dpo - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_404828_1 865937.Gilli_1112 1.23e-33 132.0 29ZGV@1|root,30MGK@2|Bacteria,4PA9P@976|Bacteroidetes,1IMU2@117743|Flavobacteriia,2P7HK@244698|Gillisia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_377879_2 977880.RALTA_B0417 1.24e-11 68.9 COG5164@1|root,COG5164@2|Bacteria,1N2ZN@1224|Proteobacteria,2W0KB@28216|Betaproteobacteria,1KCZE@119060|Burkholderiaceae 28216|Betaproteobacteria K regulation of DNA-templated transcription, elongation - - - - - - - - - - - - - k59_215993_1 941449.dsx2_2650 5.25e-09 65.5 2DNU8@1|root,32Z5M@2|Bacteria,1NARQ@1224|Proteobacteria,432SD@68525|delta/epsilon subdivisions,2WY7K@28221|Deltaproteobacteria,2MD12@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_162063_3 592015.HMPREF1705_01273 0.000768 49.3 COG0202@1|root,COG0202@2|Bacteria,3TA7T@508458|Synergistetes 508458|Synergistetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_13697_2 1247963.JPHU01000002_gene2467 8.92e-21 89.0 2DMHT@1|root,32RN3@2|Bacteria,1N0KK@1224|Proteobacteria,2UCFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - MA20_36130 - - - - - - - - - - - PEGA k59_67726_1 942016.E9NIJ0_9CAUD 2.57e-26 107.0 4QF0B@10239|Viruses,4QX8P@35237|dsDNA viruses no RNA stage,4QSJT@28883|Caudovirales,4QNNK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_215998_1 909943.HIMB100_00023400 8.33e-51 171.0 COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria,2U2NZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_190368_2 521000.PROVRETT_05969 1.09e-68 215.0 2DIG9@1|root,3036R@2|Bacteria,1RBPA@1224|Proteobacteria,1S2FC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_190370_1 272942.RCAP_rcc02907 2.06e-22 101.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,1FD1T@1060|Rhodobacter 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Lambda_tail_I,Phage-tail_3 k59_284750_1 204536.SULAZ_0041 1.99e-29 126.0 COG0587@1|root,COG0587@2|Bacteria,2G3PZ@200783|Aquificae 200783|Aquificae L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_365756_1 948071.S4S2F8_9CAUD 9.87e-05 50.1 4QGCH@10239|Viruses,4QYIQ@35237|dsDNA viruses no RNA stage,4QU4V@28883|Caudovirales,4QNJ3@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_122933_1 189425.PGRAT_28930 2.56e-10 71.6 2F5GB@1|root,33Y1Y@2|Bacteria,1VWA9@1239|Firmicutes,4ISQ2@91061|Bacilli,2776D@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_69459_1 1121403.AUCV01000053_gene2657 4.87e-45 153.0 COG2932@1|root,COG2932@2|Bacteria,1R788@1224|Proteobacteria,43AFJ@68525|delta/epsilon subdivisions,2X5V8@28221|Deltaproteobacteria,2MJCQ@213118|Desulfobacterales 28221|Deltaproteobacteria K Bacteriophage CI repressor helix-turn-helix domain - - - - - - - - - - - - Peptidase_S24,Phage_CI_repr k59_69459_2 396588.Tgr7_0387 3.43e-19 85.1 2DGRB@1|root,2ZX02@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_69459_3 1231377.C426_0909 1.59e-16 88.6 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HDG6@91061|Bacilli,1YB5P@1357|Lactococcus 91061|Bacilli L Belongs to the 'phage' integrase family int2 - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase k59_30510_1 580327.Tthe_0782 0.00065 43.5 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1TPHP@1239|Firmicutes,24E7K@186801|Clostridia,42FIJ@68295|Thermoanaerobacterales 186801|Clostridia H PFAM DNA methylase N-4 N-6 domain protein - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_314830_1 163908.KB235896_gene262 3.9e-54 194.0 COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,1G2VV@1117|Cyanobacteria,1HQES@1161|Nostocales 1117|Cyanobacteria Q Laminin G domain - - - - - - - - - - - - Laminin_G_3 k59_420901_2 1692244.A0A0K1RLR5_9CIRC 3.21e-59 195.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_272525_1 74546.PMT9312_1155 1.21e-50 176.0 COG1793@1|root,COG1793@2|Bacteria 2|Bacteria L dna ligase - - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K01971,ko:K10747 ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,WGR k59_139015_2 572478.Vdis_0183 1.5e-07 60.1 COG0343@1|root,arCOG03726@1|root,arCOG00989@2157|Archaea,arCOG03726@2157|Archaea 2157|Archaea J Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs - - - - - - - - - - - - H2O2_YaaD,TGT k59_259759_1 1280689.AUJC01000011_gene1501 3.16e-29 116.0 COG3935@1|root,COG3935@2|Bacteria,1VAP8@1239|Firmicutes,25JVR@186801|Clostridia,36PZT@31979|Clostridiaceae 186801|Clostridia L DnaD domain protein - - - - - - - - - - - - - k59_421023_3 1207076.ALAT01000190_gene2994 1.61e-18 85.1 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1Z15M@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O COG3118 Thioredoxin domain-containing protein ybbN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077 - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_72197_1 345201.VF184_IIV3 3.67e-162 480.0 4QAY9@10239|Viruses,4QV7W@35237|dsDNA viruses no RNA stage 10239|Viruses S D5 N terminal like - GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_139176_2 691965.D4P7C5_9CAUD 0.0 946.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_139176_3 742740.HMPREF9474_02271 9.2e-164 474.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,221RR@1506553|Lachnoclostridium 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_139176_4 691965.D4P7D6_9CAUD 1.13e-61 209.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_357222_1 1168478.I6S2F3_9CAUD 1.71e-34 130.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_422505_1 1121904.ARBP01000022_gene3495 1.97e-22 101.0 COG1475@1|root,COG1475@2|Bacteria,4NQCX@976|Bacteroidetes,47QYM@768503|Cytophagia 976|Bacteroidetes K DNA binding - - - - - - - - - - - - ParBc k59_180723_2 307480.IW16_06315 7.48e-73 239.0 COG0270@1|root,COG0270@2|Bacteria,4NH5Z@976|Bacteroidetes,1I83E@117743|Flavobacteriia 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_381761_1 1286631.X805_15000 7.64e-15 81.6 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2WBSH@28216|Betaproteobacteria,1KP2Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_74627_2 316274.Haur_4766 7.61e-33 129.0 COG0209@1|root,COG0209@2|Bacteria,2GAH4@200795|Chloroflexi,37643@32061|Chloroflexia 32061|Chloroflexia F ATP-cone domain protein - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC k59_45419_1 1636182.A0A0F6TGS4_9CAUD 2.57e-06 56.6 4QAKE@10239|Viruses,4QPCE@28883|Caudovirales,4QI56@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_208950_1 1379722.S5SY31_9CIRC 5.31e-49 166.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_74634_3 640513.Entas_2699 3.93e-23 99.0 COG1403@1|root,COG1403@2|Bacteria,1RHFB@1224|Proteobacteria,1S2TZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Bacteriophage Lambda NinG protein - - - - - - - - - - - - NinG k59_153619_1 11082.PRO_0000037753 6.1e-180 528.0 4QBXT@10239|Viruses,4R138@439488|ssRNA viruses,4R0R1@35278|ssRNA positive-strand viruses no DNA stage 10239|Viruses K ATP-dependent helicase activity - GO:0000122,GO:0001172,GO:0001510,GO:0001558,GO:0001817,GO:0001818,GO:0001932,GO:0001933,GO:0001934,GO:0001959,GO:0001960,GO:0001961,GO:0002039,GO:0002673,GO:0002674,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002791,GO:0002792,GO:0002831,GO:0002832,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0003824,GO:0003968,GO:0004175,GO:0004252,GO:0004483,GO:0005102,GO:0005124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005793,GO:0006139,GO:0006355,GO:0006357,GO:0006396,GO:0006417,GO:0006508,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0007155,GO:0007159,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008174,GO:0008233,GO:0008236,GO:0008270,GO:0008284,GO:0008285,GO:0008757,GO:0009058,GO:0009059,GO:0009451,GO:0009452,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010692,GO:0010694,GO:0010803,GO:0010804,GO:0010821,GO:0010823,GO:0010921,GO:0010922,GO:0010941,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016070,GO:0016071,GO:0016192,GO:0016462,GO:0016556,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017016,GO:0017111,GO:0017137,GO:0017151,GO:0017171,GO:0018130,GO:0018995,GO:0019048,GO:0019049,GO:0019050,GO:0019054,GO:0019056,GO:0019058,GO:0019065,GO:0019068,GO:0019080,GO:0019082,GO:0019215,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019899,GO:0019900,GO:0019902,GO:0019903,GO:0020012,GO:0022610,GO:0023051,GO:0023056,GO:0023057,GO:0030162,GO:0030234,GO:0030260,GO:0030307,GO:0030430,GO:0030682,GO:0030683,GO:0030888,GO:0030889,GO:0031072,GO:0031090,GO:0031267,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031330,GO:0031347,GO:0031348,GO:0031369,GO:0031399,GO:0031400,GO:0031401,GO:0031952,GO:0031953,GO:0032069,GO:0032074,GO:0032101,GO:0032102,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032465,GO:0032467,GO:0032675,GO:0032715,GO:0032774,GO:0032780,GO:0032879,GO:0032880,GO:0032944,GO:0032945,GO:0032991,GO:0032993,GO:0033036,GO:0033043,GO:0033116,GO:0033592,GO:0033643,GO:0033644,GO:0033645,GO:0033646,GO:0033647,GO:0033648,GO:0033650,GO:0033655,GO:0033662,GO:0033663,GO:0033668,GO:0033673,GO:0034062,GO:0034121,GO:0034122,GO:0034135,GO:0034136,GO:0034143,GO:0034144,GO:0034155,GO:0034156,GO:0034163,GO:0034164,GO:0034248,GO:0034250,GO:0034641,GO:0034654,GO:0035303,GO:0035306,GO:0035325,GO:0035663,GO:0035821,GO:0036260,GO:0036265,GO:0039502,GO:0039503,GO:0039506,GO:0039507,GO:0039513,GO:0039516,GO:0039526,GO:0039527,GO:0039547,GO:0039560,GO:0039580,GO:0039584,GO:0039612,GO:0039613,GO:0039644,GO:0039653,GO:0039656,GO:0039657,GO:0039713,GO:0039714,GO:0040008,GO:0042000,GO:0042025,GO:0042127,GO:0042287,GO:0042288,GO:0042325,GO:0042326,GO:0042327,GO:0042509,GO:0042532,GO:0042802,GO:0042886,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043086,GO:0043122,GO:0043123,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043414,GO:0043462,GO:0043487,GO:0043489,GO:0043549,GO:0043656,GO:0043657,GO:0043900,GO:0043901,GO:0043902,GO:0043903,GO:0044003,GO:0044053,GO:0044068,GO:0044092,GO:0044093,GO:0044164,GO:0044165,GO:0044167,GO:0044177,GO:0044186,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044220,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044279,GO:0044359,GO:0044362,GO:0044403,GO:0044409,GO:0044413,GO:0044414,GO:0044415,GO:0044417,GO:0044419,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0044531,GO:0044532,GO:0044766,GO:0044833,GO:0044877,GO:0045069,GO:0045070,GO:0045088,GO:0045184,GO:0045727,GO:0045787,GO:0045824,GO:0045862,GO:0045892,GO:0045927,GO:0045934,GO:0045936,GO:0045937,GO:0046425,GO:0046426,GO:0046483,GO:0046718,GO:0046755,GO:0046762,GO:0046774,GO:0046794,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0048583,GO:0048584,GO:0048585,GO:0050670,GO:0050672,GO:0050687,GO:0050688,GO:0050689,GO:0050690,GO:0050691,GO:0050708,GO:0050709,GO:0050727,GO:0050728,GO:0050730,GO:0050732,GO:0050776,GO:0050777,GO:0050789,GO:0050790,GO:0050792,GO:0050794,GO:0050864,GO:0050865,GO:0050866,GO:0050869,GO:0050896,GO:0051020,GO:0051046,GO:0051047,GO:0051048,GO:0051049,GO:0051050,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051253,GO:0051302,GO:0051336,GO:0051338,GO:0051345,GO:0051346,GO:0051348,GO:0051701,GO:0051704,GO:0051707,GO:0051726,GO:0051781,GO:0051805,GO:0051806,GO:0051807,GO:0051808,GO:0051817,GO:0051828,GO:0051832,GO:0051833,GO:0051834,GO:0051836,GO:0052026,GO:0052027,GO:0052029,GO:0052031,GO:0052037,GO:0052038,GO:0052040,GO:0052041,GO:0052053,GO:0052055,GO:0052056,GO:0052148,GO:0052150,GO:0052167,GO:0052170,GO:0052173,GO:0052199,GO:0052200,GO:0052203,GO:0052204,GO:0052205,GO:0052230,GO:0052248,GO:0052250,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052312,GO:0052433,GO:0052490,GO:0052493,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060147,GO:0060149,GO:0060255,GO:0060338,GO:0060339,GO:0060341,GO:0060548,GO:0060589,GO:0060590,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0060759,GO:0060760,GO:0060761,GO:0060966,GO:0060967,GO:0060968,GO:0060969,GO:0065007,GO:0065008,GO:0065009,GO:0070011,GO:0070103,GO:0070104,GO:0070201,GO:0070486,GO:0070663,GO:0070664,GO:0071593,GO:0071702,GO:0071704,GO:0071705,GO:0072583,GO:0075109,GO:0075111,GO:0075112,GO:0075114,GO:0075136,GO:0075344,GO:0075509,GO:0075512,GO:0075528,GO:0080009,GO:0080090,GO:0080134,GO:0080135,GO:0090068,GO:0090087,GO:0090199,GO:0090201,GO:0090304,GO:0097159,GO:0097617,GO:0097659,GO:0097677,GO:0097747,GO:0098588,GO:0098609,GO:0098657,GO:0098772,GO:0106005,GO:0140096,GO:0140098,GO:1900101,GO:1900102,GO:1900117,GO:1900118,GO:1900368,GO:1900369,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1902369,GO:1902531,GO:1902532,GO:1902533,GO:1902579,GO:1902679,GO:1903265,GO:1903506,GO:1903507,GO:1903530,GO:1903531,GO:1903573,GO:1903719,GO:1903721,GO:1903900,GO:1903902,GO:1904892,GO:1904893,GO:1904950,GO:1905897,GO:1990214,GO:1990216,GO:1990219,GO:1990254,GO:1990814,GO:1990904,GO:2000112,GO:2000113,GO:2001141,GO:2001233,GO:2001234 - - - - - - - - - - - k59_329469_1 985255.APHJ01000018_gene3097 3.12e-11 66.6 COG5545@1|root,COG5545@2|Bacteria,4PMA3@976|Bacteroidetes,1IJP7@117743|Flavobacteriia 976|Bacteroidetes L VirE N-terminal domain - - - - - - - - - - - - DUF3987,PriCT_2,VirE,VirE_N k59_142018_1 316278.SynRCC307_0753 1.98e-13 74.7 COG0507@1|root,COG0507@2|Bacteria,1G8N5@1117|Cyanobacteria,1GZPG@1129|Synechococcus 1117|Cyanobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member - - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_330727_9 395964.KE386496_gene2697 3.35e-08 60.1 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,3N9MI@45404|Beijerinckiaceae 28211|Alphaproteobacteria M Peptidase family M23 MA20_20375 - - - - - - - - - - - Peptidase_M23 k59_127380_1 1341155.FSS13T_06400 0.000362 51.2 COG1345@1|root,COG2374@1|root,COG3897@1|root,COG1345@2|Bacteria,COG2374@2|Bacteria,COG3897@2|Bacteria,4NFVP@976|Bacteroidetes,1IIIJ@117743|Flavobacteriia,2P0E0@237|Flavobacterium 976|Bacteroidetes N Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - CUB,He_PIG,LTD k59_264007_2 1255043.TVNIR_3567 7.75e-12 64.7 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_411970_1 1463926.JOCA01000002_gene5903 7e-12 73.9 COG0542@1|root,COG1372@1|root,COG0542@2|Bacteria,COG1372@2|Bacteria,2HUM7@201174|Actinobacteria 201174|Actinobacteria LO LAGLIDADG-like domain - - - - - - - - - - - - AAA,AAA_2,LAGLIDADG_3 k59_289627_1 38033.XP_001219967.1 8.93e-06 55.1 2ECWC@1|root,2SINF@2759|Eukaryota,39VYZ@33154|Opisthokonta,3P0FH@4751|Fungi,3QSDA@4890|Ascomycota,21NSZ@147550|Sordariomycetes,3UB1M@5139|Sordariales,3HGJE@35718|Chaetomiaceae 4751|Fungi S Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_359648_2 579138.Zymop_0823 1.14e-60 206.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,2K7D4@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_6710_2 666510.ASAC_0989 8.27e-19 82.8 COG0526@1|root,arCOG01972@2157|Archaea,2XQQ2@28889|Crenarchaeota 28889|Crenarchaeota O TIGRFAM thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_77407_4 1122917.KB899659_gene6072 0.00053 52.4 COG5301@1|root,COG5301@2|Bacteria,1V8R8@1239|Firmicutes,4I0X7@91061|Bacilli,26YC4@186822|Paenibacillaceae 91061|Bacilli S Phage tail-collar fibre protein - - - - - - - - - - - - DUF3751 k59_20868_2 748449.Halha_2554 6.92e-05 47.8 COG0791@1|root,COG0791@2|Bacteria,1UFCF@1239|Firmicutes,24KQ5@186801|Clostridia,3WBW7@53433|Halanaerobiales 186801|Clostridia M NlpC/P60 family - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 k59_89440_5 633131.TR2A62_1181 4.99e-09 60.5 COG0500@1|root,COG0500@2|Bacteria,1RIQB@1224|Proteobacteria,2U356@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_23 k59_114482_2 691965.D4P7C3_9CAUD 1.64e-28 107.0 4QDCX@10239|Viruses,4R0GS@35237|dsDNA viruses no RNA stage,4QS3P@28883|Caudovirales,4QKU8@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_114482_3 411460.RUMTOR_01352 1.68e-59 187.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_114482_4 742733.HMPREF9469_05037 3.07e-23 93.6 2BD7A@1|root,326VE@2|Bacteria,1USRB@1239|Firmicutes,25ASG@186801|Clostridia,223BG@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_359918_2 1172186.KB911462_gene141 2.04e-13 71.2 COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,235KY@1762|Mycobacteriaceae 201174|Actinobacteria T Histidine kinase phoR - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_182413_1 1406780.U5PW18_9CAUD 2.54e-57 206.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_61225_1 381666.H16_B0577 7.4e-11 58.2 COG4456@1|root,COG4456@2|Bacteria,1N2HQ@1224|Proteobacteria,2VW5X@28216|Betaproteobacteria,1K9NN@119060|Burkholderiaceae 28216|Betaproteobacteria S SpoVT AbrB - - - ko:K18829 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_127600_2 1100720.ALKN01000018_gene1738 5.77e-46 167.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VQF3@28216|Betaproteobacteria,4ADUP@80864|Comamonadaceae 28216|Betaproteobacteria L Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_276105_1 1121895.Q765_14930 2.55e-28 117.0 28KN5@1|root,2ZA6E@2|Bacteria,4NIXS@976|Bacteroidetes,1ICTE@117743|Flavobacteriia,2NUM9@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_306242_1 1408428.JNJP01000003_gene3493 1.13e-69 219.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_49499_1 1235800.C819_02953 8.84e-05 52.4 COG0270@1|root,COG0270@2|Bacteria,1TR36@1239|Firmicutes,249XY@186801|Clostridia,27JR6@186928|unclassified Lachnospiraceae 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_372489_1 391038.Bphy_7605 6.09e-09 55.8 COG0582@1|root,COG0582@2|Bacteria,1RD98@1224|Proteobacteria,2VSQP@28216|Betaproteobacteria,1K5NJ@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM integrase family protein - - - - - - - - - - - - - k59_372489_2 391038.Bphy_7606 3.52e-74 223.0 2EIIU@1|root,33CA4@2|Bacteria,1NP4X@1224|Proteobacteria,2W2SY@28216|Betaproteobacteria,1K7W2@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_348554_8 715451.ambt_03635 2.19e-21 94.7 2C1TB@1|root,2ZB27@2|Bacteria,1N020@1224|Proteobacteria,1SA40@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_116533_1 1047013.AQSP01000127_gene496 3.12e-18 80.1 2E5C1@1|root,33MIF@2|Bacteria 1047013.AQSP01000127_gene496|- - - - - - - - - - - - - - - - k59_222338_1 1122951.ATUE01000006_gene1033 1.09e-18 87.4 2EJXI@1|root,33DN6@2|Bacteria,1NKIP@1224|Proteobacteria,1SRVY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_148209_1 665942.HMPREF1022_02940 2.56e-135 438.0 COG0553@1|root,COG0827@1|root,COG1040@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG1040@2|Bacteria,COG4646@2|Bacteria,1PGZG@1224|Proteobacteria,42NYW@68525|delta/epsilon subdivisions 1224|Proteobacteria L COG0827 Adenine-specific DNA methylase - - - - - - - - - - - - Eco57I,Helicase_C,N6_Mtase,ResIII,SNF2_N k59_170697_1 675812.VHA_000185 1.83e-11 68.9 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1XSJQ@135623|Vibrionales 135623|Vibrionales D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009009,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_170697_2 471874.PROSTU_01892 2.3e-43 144.0 2E1C1@1|root,32WRT@2|Bacteria,1QUUX@1224|Proteobacteria,1SNVY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_37031_1 1540097.A0A0A0YUA7_9CAUD 8.92e-69 217.0 4QGM6@10239|Viruses,4QRH4@28883|Caudovirales,4QP0P@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_129899_1 1121365.AQXB01000009_gene565 8.31e-40 155.0 COG5412@1|root,COG5412@2|Bacteria,2IH91@201174|Actinobacteria 201174|Actinobacteria E phage tail tape measure protein - - - - - - - - - - - - - k59_372748_1 1120971.AUCA01000053_gene371 3.38e-88 266.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_197727_2 270673.Q6PVM5_9CAUD 1.83e-25 99.4 4QGQX@10239|Viruses,4QQ2D@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_186567_1 1220551.SCHR_00610 3.74e-27 118.0 COG0739@1|root,COG3953@1|root,COG5283@1|root,COG5412@1|root,COG0739@2|Bacteria,COG3953@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,4HAFE@91061|Bacilli,4GY27@90964|Staphylococcaceae 91061|Bacilli M Phage tail tape measure protein - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k59_186569_1 639283.Snov_0721 7.06e-19 88.6 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_5,Big_5,fn3 k59_11507_1 1230338.MOMA_06891 5.69e-50 174.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_374620_1 639283.Snov_1953 7.09e-16 86.7 COG5281@1|root,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2TW9T@28211|Alphaproteobacteria,3F0FI@335928|Xanthobacteraceae 28211|Alphaproteobacteria S tape measure protein - - - - - - - - - - - - - k59_186582_2 1173762.S4TRS0_9CAUD 6.62e-23 95.1 4QDXM@10239|Viruses,4QWIX@35237|dsDNA viruses no RNA stage,4QQF6@28883|Caudovirales,4QNXH@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_173818_3 645099.MREP_BBTVA 1.66e-09 61.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_224525_1 1210908.HSB1_41450 1.92e-57 199.0 COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria 183963|Halobacteria P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_254234_1 448385.sce7377 1.66e-07 52.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,2Z0DM@29|Myxococcales 28221|Deltaproteobacteria M RmlD substrate binding domain uge - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_254234_4 693746.OBV_05400 1.96e-09 63.2 COG0438@1|root,COG0438@2|Bacteria,1UJHE@1239|Firmicutes,24F61@186801|Clostridia 186801|Clostridia M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_1 k59_280766_2 582899.Hden_0109 2.18e-22 94.4 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2UIHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Pathogenesis-related transcriptional factor and ERF protein - - - - - - - - - - - - AP2,HNH_3 k59_428531_1 1220589.CD32_13625 9.38e-06 53.5 COG4675@1|root,COG4675@2|Bacteria,1VHKQ@1239|Firmicutes,4HVG0@91061|Bacilli,3IY30@400634|Lysinibacillus 91061|Bacilli S Phage Tail Collar Domain mdpB - - - - - - - - - - - Collar k59_65563_1 1134912.AJTV01000007_gene1098 7.35e-07 56.2 COG0863@1|root,COG0863@2|Bacteria,1R8XS@1224|Proteobacteria,2U18H@28211|Alphaproteobacteria,36Z9T@31993|Methylocystaceae 28211|Alphaproteobacteria L DNA methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_106677_4 443254.Marpi_0338 3.38e-12 79.7 COG3500@1|root,COG4733@1|root,COG3500@2|Bacteria,COG4733@2|Bacteria,2GDX2@200918|Thermotogae 200918|Thermotogae S Fibronectin type 3 domain - - - - - - - - - - - - - k59_418229_8 1197951.I6S295_9CAUD 1.51e-45 148.0 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_418229_11 69279.BG36_20875 1.5e-179 521.0 COG1783@1|root,COG4373@1|root,COG1783@2|Bacteria,COG4373@2|Bacteria,1PE12@1224|Proteobacteria,2V9EC@28211|Alphaproteobacteria,43QJZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Mu-like prophage FluMu protein gp28 - - - - - - - - - - - - - k59_418229_13 1235788.C802_00067 4.06e-07 56.6 COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FQKQ@200643|Bacteroidia,4AQK8@815|Bacteroidaceae 976|Bacteroidetes K ParB-like nuclease domain - - - - - - - - - - - - DUF4417,ParBc k59_243030_1 626887.J057_01685 3.21e-50 167.0 28HS3@1|root,2Z7ZE@2|Bacteria,1QH9A@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_404913_1 691965.D4P7B9_9CAUD 2.82e-35 124.0 4QFDH@10239|Viruses,4QWV5@35237|dsDNA viruses no RNA stage,4QPB8@28883|Caudovirales,4QKNN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_243035_1 1618247.A0A0C5IMK7_9CIRC 1.87e-09 63.5 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_189097_7 888727.HMPREF9092_1281 1.23e-78 279.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WCF4@538999|Clostridiales incertae sedis 186801|Clostridia L Helix-hairpin-helix motif dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_13754_1 1566990.A0A0A0YV29_9CAUD 0.000169 48.5 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0003824,GO:0005575,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019012,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - - k59_229444_1 1448389.BAVQ01000016_gene4043 4.36e-60 203.0 COG3740@1|root,COG3740@2|Bacteria,2IPJH@201174|Actinobacteria 201174|Actinobacteria S Phage prohead protease, HK97 family - - - - - - - - - - - - - k59_229444_2 1448389.BAVQ01000016_gene4044 2.38e-19 83.6 2AXAN@1|root,31P9R@2|Bacteria,2GZAI@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_229444_5 888439.HMPREF9240_01022 1.14e-17 80.9 2FJV8@1|root,34BHS@2|Bacteria,2HZNG@201174|Actinobacteria,4D6SD@85005|Actinomycetales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_270053_2 1217710.F969_00662 3.8e-31 124.0 28IQ7@1|root,2Z8PY@2|Bacteria,1NA66@1224|Proteobacteria,1S212@1236|Gammaproteobacteria,3NMNM@468|Moraxellaceae 1236|Gammaproteobacteria S RecT family - - - - - - - - - - - - RecT k59_135100_1 105422.BBPM01000058_gene4616 1.82e-64 224.0 COG1475@1|root,COG4422@1|root,COG1475@2|Bacteria,COG4422@2|Bacteria,2IAY7@201174|Actinobacteria,2NK47@228398|Streptacidiphilus 201174|Actinobacteria K DNA binding - - - - - - - - - - - - ParBc k59_67914_6 388051.AUFE01000002_gene392 8.26e-09 66.2 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2VM4U@28216|Betaproteobacteria,1K9P6@119060|Burkholderiaceae 28216|Betaproteobacteria S COG Phage tail sheath protein FI - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_283618_2 13616.ENSMODP00000005559 3.51e-29 114.0 COG2096@1|root,2QS64@2759|Eukaryota,399ET@33154|Opisthokonta,3BDEZ@33208|Metazoa,3CZ9D@33213|Bilateria,48670@7711|Chordata,491CZ@7742|Vertebrata,3JCJ8@40674|Mammalia,4K5W6@9263|Metatheria 33208|Metazoa S Methylmalonic aciduria (cobalamin deficiency) cblB type MMAB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008817,GO:0009235,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0019842,GO:0031419,GO:0031974,GO:0033013,GO:0036094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046906,GO:0048037,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_163315_3 10224.XP_002738206.1 2.42e-15 79.0 KOG0084@1|root,KOG0084@2759|Eukaryota 2759|Eukaryota S GTPase activity - - - ko:K07874,ko:K07912,ko:K07920,ko:K13681 ko04140,ko05134,map04140,map05134 - - - ko00000,ko00001,ko01000,ko01003,ko04031,ko04131,ko04147 - GT37 - Ras k59_1694_1 1161401.ASJA01000008_gene1658 6.06e-12 68.6 2CJWY@1|root,33MF9@2|Bacteria,1NKUU@1224|Proteobacteria,2UMVZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_298402_5 93220.LV28_18955 2.56e-05 55.1 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,1K18Q@119060|Burkholderiaceae 28216|Betaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_365926_1 205920.ECH_0761 5.71e-13 76.6 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,47ETE@766|Rickettsiales 766|Rickettsiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_190512_2 760568.Desku_1125 1.51e-20 90.1 2FC7I@1|root,344BB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_352826_1 744979.R2A130_2473 2.42e-15 73.2 2DMHT@1|root,32RN3@2|Bacteria,1N0KK@1224|Proteobacteria,2UCFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - MA20_36130 - - - - - - - - - - - PEGA k59_244670_1 1082931.KKY_773 4.94e-10 67.4 28JTG@1|root,2Z7PY@2|Bacteria,1QVNY@1224|Proteobacteria,2TXVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_244670_4 1123227.KB899333_gene773 5.01e-162 476.0 COG1783@1|root,COG1783@2|Bacteria,1QUEN@1224|Proteobacteria,2TZM9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Mu-like prophage FluMu protein gp28 - - - - - - - - - - - - - k59_244670_6 665942.HMPREF1022_00141 8.13e-88 289.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,42YKK@68525|delta/epsilon subdivisions,2WUDS@28221|Deltaproteobacteria,2M8E7@213115|Desulfovibrionales 28221|Deltaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_230874_2 760568.Desku_1126 7.69e-54 181.0 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1TT7N@1239|Firmicutes,24D10@186801|Clostridia 186801|Clostridia L ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_258231_1 1262528.L7TJ57_9VIRU 8.17e-26 102.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage 10239|Viruses S HNH endonuclease - - - - - - - - - - - - - k59_163528_1 1121921.KB898706_gene3023 2.49e-12 62.8 28UBS@1|root,2ZGH5@2|Bacteria,1P4E2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1888_1 1307761.L21SP2_2164 1.9e-13 71.6 COG1562@1|root,COG1562@2|Bacteria,2J9JW@203691|Spirochaetes 203691|Spirochaetes I Squalene/phytoene synthase - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_1888_2 935863.AWZR01000004_gene385 8.24e-32 116.0 COG4898@1|root,COG4898@2|Bacteria,1N0Z1@1224|Proteobacteria,1SQ7K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_109731_1 1173709.M3VMK9_9CIRC 2.54e-27 110.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_313030_2 102129.Lepto7375DRAFT_1759 1.9e-26 100.0 2C3RK@1|root,32WX9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_341654_1 1416009.V9VCX5_9CAUD 3.33e-38 140.0 4QEG2@10239|Viruses,4QVSD@35237|dsDNA viruses no RNA stage,4QRJ9@28883|Caudovirales,4QP0R@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_178642_1 644966.Tmar_0370 5.87e-67 233.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WCF4@538999|Clostridiales incertae sedis 186801|Clostridia L Helix-hairpin-helix motif dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_30683_1 1125863.JAFN01000001_gene843 2.47e-16 84.0 COG0467@1|root,COG0467@2|Bacteria,1RFBT@1224|Proteobacteria,42QWP@68525|delta/epsilon subdivisions,2WMB2@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - - - - - - - - - - - k59_206477_1 478749.BRYFOR_08565 1.32e-32 123.0 2A0KC@1|root,2ZGJK@2|Bacteria,1V2JS@1239|Firmicutes,24H6R@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_206477_2 428125.CLOLEP_01371 1.51e-05 52.4 2EGRD@1|root,33AHJ@2|Bacteria,1VMXW@1239|Firmicutes,24UKW@186801|Clostridia,3WP1E@541000|Ruminococcaceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_206477_4 742740.HMPREF9474_02303 1.92e-41 157.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,221YV@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_57662_2 94624.Bpet1702 3.37e-21 97.8 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,3T4AX@506|Alcaligenaceae 28216|Betaproteobacteria L Uracil-DNA glycosylase dpo - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_218466_4 488538.SAR116_0381 0.00011 52.4 2ES2P@1|root,33JMP@2|Bacteria,1NGYH@1224|Proteobacteria,2UMK8@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_85209_3 1379710.S5TNC2_9CIRC 1.35e-14 78.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_286554_1 706587.Desti_4040 1.08e-14 73.2 COG1432@1|root,COG1432@2|Bacteria,1RJ15@1224|Proteobacteria,43B69@68525|delta/epsilon subdivisions,2WTA1@28221|Deltaproteobacteria 28221|Deltaproteobacteria S NYN domain - - - - - - - - - - - - NYN k59_246553_1 1123320.KB889607_gene9504 2.91e-34 138.0 COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria 201174|Actinobacteria O AAA ATPase central domain protein - - - - - - - - - - - - AAA,Beta_helix k59_206699_1 1041159.AZUW01000018_gene765 0.000163 48.5 COG1475@1|root,COG1475@2|Bacteria,1QAFW@1224|Proteobacteria,2U1MZ@28211|Alphaproteobacteria,4BB0X@82115|Rhizobiaceae 28211|Alphaproteobacteria K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc,RepB k59_151980_1 1385658.U5KPZ6_9VIRU 1.39e-49 174.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_421102_1 1437882.AZRU01000111_gene4953 2.07e-38 135.0 2CEI6@1|root,2ZED5@2|Bacteria,1RCK0@1224|Proteobacteria,1SJIE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_341947_1 1114964.L485_22380 1.73e-16 79.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - N6_N4_Mtase k59_151983_1 1536592.A0A088F776_9VIRU 5.47e-55 182.0 4QF7M@10239|Viruses 10239|Viruses S AAA domain - - - - - - - - - - - - - k59_317736_1 293826.Amet_0541 2.17e-10 67.8 COG1388@1|root,COG3409@1|root,COG1388@2|Bacteria,COG3409@2|Bacteria,1V10C@1239|Firmicutes 1239|Firmicutes M PFAM LysM domain - - - - - - - - - - - - LysM k59_274363_1 886379.AEWI01000001_gene1729 0.000192 52.0 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria,4PJA9@976|Bacteroidetes,2G1GP@200643|Bacteroidia,3XKYZ@558415|Marinilabiliaceae 976|Bacteroidetes D tape measure - - - - - - - - - - - - - k59_74979_1 1250232.JQNJ01000001_gene3360 2.23e-51 181.0 COG3291@1|root,COG3291@2|Bacteria,4PMR5@976|Bacteroidetes,1IJX3@117743|Flavobacteriia 976|Bacteroidetes N cellulose binding - - - - - - - - - - - - Big_2 k59_142403_1 945713.IALB_0184 0.000244 51.6 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - PKD,PSII_BNR,Sortilin-Vps10 k59_422738_1 1692242.A0A0K1RL37_9CIRC 2.67e-16 84.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_329665_1 1268240.ATFI01000007_gene743 1.96e-16 80.1 COG3023@1|root,COG3023@2|Bacteria,4P37K@976|Bacteroidetes,2FRZB@200643|Bacteroidia,4AQJD@815|Bacteroidaceae 976|Bacteroidetes V Psort location Cytoplasmic, score 8.96 - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_357621_2 498761.HM1_0049 5.46e-134 401.0 COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia 186801|Clostridia S Mu-like prophage protein gp29 - - - - - - - - - - - - - k59_357621_3 1123508.JH636441_gene3582 9.26e-166 478.0 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - - - - - - - - - - Terminase_6,Terminase_6C k59_112986_2 1415780.JPOG01000001_gene1170 0.000592 48.5 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1X48C@135614|Xanthomonadales 135614|Xanthomonadales L dna polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_381984_2 1109445.AGSX01000199_gene2949 6.56e-73 239.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1TKGS@1236|Gammaproteobacteria,1Z49H@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_75029_1 281090.Lxx03850 8.62e-20 90.9 2AYW5@1|root,31R1R@2|Bacteria,2HT7A@201174|Actinobacteria,4FS92@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_422759_1 1121285.AUFK01000002_gene40 9.83e-25 102.0 29D2S@1|root,3000U@2|Bacteria,4PGQF@976|Bacteroidetes,1IM4Y@117743|Flavobacteriia,3ZSNA@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_274588_1 1121441.AUCX01000020_gene668 2.29e-10 68.6 COG0110@1|root,COG3562@1|root,COG0110@2|Bacteria,COG3562@2|Bacteria,1N6SQ@1224|Proteobacteria,42VI7@68525|delta/epsilon subdivisions,2WR74@28221|Deltaproteobacteria,2MAVN@213115|Desulfovibrionales 28221|Deltaproteobacteria Q transferase hexapeptide repeat - - 2.3.1.18 ko:K00633,ko:K03818 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 k59_422971_3 1121100.JCM6294_1073 7.11e-11 63.5 COG3613@1|root,COG3613@2|Bacteria,4NWKS@976|Bacteroidetes,2FUAN@200643|Bacteroidia,4AVJQ@815|Bacteroidaceae 976|Bacteroidetes F Domain of unknown function (DUF4406) - - - - - - - - - - - - Bac_DnaA_C,DUF4406 k59_422971_5 1123230.ARQJ01000027_gene1330 2.6e-26 103.0 COG1694@1|root,COG1694@2|Bacteria,1V99P@1239|Firmicutes,4HK8D@91061|Bacilli,4H1K9@90964|Staphylococcaceae 91061|Bacilli S MazG nucleotide pyrophosphohydrolase domain - - - - - - - - - - - - MazG k59_304388_2 1134413.ANNK01000054_gene2226 1.18e-38 152.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli,1ZB0Z@1386|Bacillus 91061|Bacilli KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_360337_1 521674.Plim_0014 1.4e-71 227.0 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_156193_1 314278.NB231_08630 8.65e-20 87.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1WW5U@135613|Chromatiales 135613|Chromatiales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - DCD,dUTPase k59_398006_3 1166130.H650_06900 1.56e-44 150.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S99W@1236|Gammaproteobacteria,3X3S4@547|Enterobacter 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_78231_1 1042163.BRLA_07p000010 1.65e-25 105.0 28KEB@1|root,3063N@2|Bacteria,1TZ4V@1239|Firmicutes,4I8BZ@91061|Bacilli,273D7@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_211793_6 1996.JOFO01000032_gene1345 3.77e-07 51.2 2CC1Y@1|root,3260I@2|Bacteria,2IRID@201174|Actinobacteria 201174|Actinobacteria K Transcription factor WhiB - - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_182885_1 1385658.U5KPZ6_9VIRU 8.05e-197 566.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_235592_1 313596.RB2501_01430 1.56e-71 222.0 COG2887@1|root,COG2887@2|Bacteria,4P6Q6@976|Bacteroidetes 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily - - - - - - - - - - - - - k59_264896_1 439235.Dalk_4615 1.95e-59 201.0 COG0582@1|root,COG0582@2|Bacteria,1R3T2@1224|Proteobacteria,42PPE@68525|delta/epsilon subdivisions,2WKWN@28221|Deltaproteobacteria,2MJ75@213118|Desulfobacterales 28221|Deltaproteobacteria L 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_331332_1 1188795.K7ZRM7_9CAUD 2.36e-13 76.6 4QHMX@10239|Viruses,4QW8C@35237|dsDNA viruses no RNA stage,4QRQS@28883|Caudovirales,4QNWI@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_90039_1 69328.PVLB_20830 1.29e-21 98.2 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_264898_3 1268240.ATFI01000009_gene1697 1.41e-05 52.4 COG4677@1|root,COG4677@2|Bacteria,4NITR@976|Bacteroidetes,2FPF5@200643|Bacteroidia,4APZ8@815|Bacteroidaceae 976|Bacteroidetes G Pectinesterase - - - - - - - - - - - - Mfa_like_1,Pectinesterase k59_9561_3 1266998.ATUJ01000011_gene2445 1.23e-16 79.7 COG0270@1|root,COG0270@2|Bacteria,1R5MR@1224|Proteobacteria,2U53Z@28211|Alphaproteobacteria,2PXYF@265|Paracoccus 28211|Alphaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_307050_1 1397284.AYMN01000081_gene2456 1.66e-08 62.8 COG4653@1|root,COG4653@2|Bacteria,1MYMH@1224|Proteobacteria,1RR5E@1236|Gammaproteobacteria,4050H@613|Serratia 1236|Gammaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_130617_1 10224.XP_002730368.1 1.5e-51 176.0 COG1678@1|root,KOG1567@2759|Eukaryota,38B80@33154|Opisthokonta,3B9U0@33208|Metazoa,3CT3A@33213|Bilateria 33208|Metazoa F ribonucleoside-diphosphate reductase activity RRM2B GO:0000002,GO:0000082,GO:0000083,GO:0000278,GO:0001655,GO:0001822,GO:0003008,GO:0003014,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005971,GO:0006139,GO:0006206,GO:0006259,GO:0006260,GO:0006261,GO:0006264,GO:0006281,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006919,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0007005,GO:0007049,GO:0007275,GO:0008150,GO:0008152,GO:0008199,GO:0008284,GO:0009058,GO:0009059,GO:0009112,GO:0009117,GO:0009141,GO:0009165,GO:0009200,GO:0009262,GO:0009263,GO:0009790,GO:0009792,GO:0009889,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010604,GO:0010646,GO:0010648,GO:0010941,GO:0010942,GO:0010948,GO:0010950,GO:0010952,GO:0012505,GO:0016043,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0022402,GO:0022607,GO:0023051,GO:0023057,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032042,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042127,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043280,GO:0043281,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0045786,GO:0045862,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051259,GO:0051262,GO:0051290,GO:0051291,GO:0051336,GO:0051345,GO:0051716,GO:0051726,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0060548,GO:0061731,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070316,GO:0070317,GO:0071704,GO:0071840,GO:0072001,GO:0072527,GO:0080090,GO:0090304,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901796,GO:1901797,GO:1902253,GO:1902254,GO:1902494,GO:1902531,GO:1902532,GO:1903047,GO:1903506,GO:1990204,GO:2000112,GO:2000116,GO:2001056,GO:2001141,GO:2001233,GO:2001234,GO:2001242,GO:2001243 1.17.4.1 ko:K10808 ko00230,ko00240,ko00480,ko00983,ko01100,ko04115,map00230,map00240,map00480,map00983,map01100,map04115 M00053 R02017,R02019,R02024,R08363,R08364,R11893 RC00613,RC01003 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_198437_1 428125.CLOLEP_01422 0.000631 48.5 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,3WN92@541000|Ruminococcaceae 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_237021_1 10717.Q9ZXC4_BPPH1 2.08e-27 118.0 4QAY9@10239|Viruses,4QV7W@35237|dsDNA viruses no RNA stage,4QPAN@28883|Caudovirales,4QKV1@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_104550_1 373903.Hore_18920 7.93e-17 80.1 COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,24CT6@186801|Clostridia,3WAF2@53433|Halanaerobiales 186801|Clostridia M PFAM DAHP synthetase I kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_104550_2 1321786.HMPREF1992_01614 1.65e-18 85.5 COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,4H20C@909932|Negativicutes 909932|Negativicutes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_307057_1 883078.HMPREF9695_04254 2.64e-22 102.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2TUGQ@28211|Alphaproteobacteria,3JXN5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_214810_2 880073.Calab_1460 4.87e-21 97.8 COG0338@1|root,COG0338@2|Bacteria 2|Bacteria L D12 class N6 adenine-specific DNA methyltransferase yqbD - 2.1.1.72 ko:K06223,ko:K15125 ko03430,ko05133,map03430,map05133 - - - ko00000,ko00001,ko00536,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12,Peptidase_S78_2 k59_278496_1 445971.ANASTE_00775 5.72e-38 149.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,25V2U@186806|Eubacteriaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_349242_1 526225.Gobs_5063 6.11e-32 134.0 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4ERFB@85013|Frankiales 201174|Actinobacteria L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_116958_1 1120792.JAFV01000001_gene592 1.64e-07 58.5 COG3740@1|root,COG3740@2|Bacteria 2|Bacteria OU Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_158909_1 1437882.AZRU01000008_gene2963 3.53e-27 104.0 2CJWY@1|root,31CWF@2|Bacteria,1RKEF@1224|Proteobacteria,1S75P@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_158909_2 1002340.AFCF01000068_gene2285 2.61e-09 63.9 COG2813@1|root,COG2813@2|Bacteria,1QV7D@1224|Proteobacteria,2TWCC@28211|Alphaproteobacteria,34G26@302485|Phaeobacter 28211|Alphaproteobacteria JM Specifically methylates the guanine in position - - - - - - - - - - - - Glyco_tranf_2_4 k59_171412_1 221288.JH992901_gene4121 1.67e-07 58.2 COG0628@1|root,COG0628@2|Bacteria,1FZWJ@1117|Cyanobacteria,1JJVW@1189|Stigonemataceae 1117|Cyanobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_92134_1 643473.KB235930_gene3744 6.79e-23 96.7 COG0343@1|root,COG0343@2|Bacteria,1GAUU@1117|Cyanobacteria,1HS8U@1161|Nostocales 1117|Cyanobacteria J queuine tRNA-ribosyltransferase activity - - - - - - - - - - - - TGT k59_92134_2 1218076.BAYB01000021_gene3712 2.04e-29 110.0 COG0343@1|root,COG0343@2|Bacteria,1NRFY@1224|Proteobacteria 1224|Proteobacteria J queuine tRNA-ribosyltransferase activity - - - - - - - - - - - - - k59_426959_1 1121877.JQKF01000027_gene2474 3.81e-108 356.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_323664_1 1028806.GGE_0504 2.92e-23 103.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RRK4@1236|Gammaproteobacteria,1Y7IC@135625|Pasteurellales 135625|Pasteurellales S Bacteriophage capsid protein - - - - - - - - - - - - Phage_portal_2 k59_106619_4 1385658.U5KNR1_9VIRU 2.45e-63 210.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_106619_6 1385658.U5KPZ6_9VIRU 2.58e-162 476.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_11730_1 428125.CLOLEP_01379 1.09e-45 159.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia,3WN6X@541000|Ruminococcaceae 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_11730_4 1476888.X4YH18_9CAUD 4.59e-23 92.4 4QG3V@10239|Viruses,4QW5T@35237|dsDNA viruses no RNA stage,4QSWE@28883|Caudovirales,4QM1Q@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_11730_5 691965.D4P7L6_9CAUD 1.9e-84 254.0 4QFKG@10239|Viruses,4QV77@35237|dsDNA viruses no RNA stage,4QR6Q@28883|Caudovirales,4QMGT@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_309438_1 627192.SLG_22000 8.38e-32 122.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,2K7D4@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_309438_2 343509.SG1821 1.58e-14 70.9 2CXUI@1|root,32T2N@2|Bacteria,1N3JB@1224|Proteobacteria,1SBAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA-packaging protein gp3 - - - - - - - - - - - - GP3_package k59_94374_3 1121923.GPUN_0291 1.57e-17 88.6 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_201140_2 1449126.JQKL01000003_gene1699 1.65e-11 67.0 COG1783@1|root,COG1783@2|Bacteria,1TT85@1239|Firmicutes,24ETQ@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Terminase_6 k59_224703_1 172088.AUGA01000082_gene6213 1.4e-43 158.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_201540_1 742767.HMPREF9456_03368 8.95e-48 179.0 COG5280@1|root,COG5280@2|Bacteria,4PNYN@976|Bacteroidetes,2FPMT@200643|Bacteroidia 976|Bacteroidetes S domain protein - - - - - - - - - - - - - k59_386565_1 1173029.JH980292_gene1131 0.000707 43.1 COG1404@1|root,COG1404@2|Bacteria,1G1SH@1117|Cyanobacteria,1HAAX@1150|Oscillatoriales 1117|Cyanobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_26174_1 1282995.R9W0A5_9CAUD 2.42e-49 167.0 4QFB4@10239|Viruses,4QZ8P@35237|dsDNA viruses no RNA stage,4QSGK@28883|Caudovirales,4QKUP@10699|Siphoviridae 10699|Siphoviridae S viral capsid - - - - - - - - - - - - - k59_174593_1 243233.MCA0875 1.6e-08 63.5 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XFQY@135618|Methylococcales 135618|Methylococcales O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_187027_1 1410668.JNKC01000005_gene2386 2.18e-71 231.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_390972_1 536232.CLM_2667 5.03e-39 146.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_284453_1 1692242.A0A0K1RKZ2_9CIRC 5.06e-11 69.7 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_284453_3 1692256.A0A0K1RL85_9CIRC 3.8e-75 240.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_149751_1 100226.SCO2589 3.09e-09 65.9 COG0463@1|root,COG1887@1|root,COG0463@2|Bacteria,COG1887@2|Bacteria,2GM0T@201174|Actinobacteria 201174|Actinobacteria M CDP-glycerol poly(glycerophosphate) glycerophosphotransferase - - - - - - - - - - - - Glycos_transf_2,Glyphos_transf k59_41845_1 391589.RGAI101_2476 2.66e-18 90.1 COG0438@1|root,COG0438@2|Bacteria,1R9FR@1224|Proteobacteria,2U3H6@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_82366_2 1382358.JHVN01000004_gene2573 4.37e-47 170.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4HAG5@91061|Bacilli,21VFN@150247|Anoxybacillus 91061|Bacilli L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_82366_7 760011.Spico_1344 8.35e-69 250.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes 203691|Spirochaetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_270966_1 691965.D4P7H8_9CAUD 3.84e-30 116.0 4QG1E@10239|Viruses,4QZE1@35237|dsDNA viruses no RNA stage,4QU6Q@28883|Caudovirales,4QMKH@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_270966_2 691965.D4P7I0_9CAUD 1.21e-77 244.0 4QDSZ@10239|Viruses,4QXJ8@35237|dsDNA viruses no RNA stage,4QPKE@28883|Caudovirales,4QM8R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_149756_1 1041826.FCOL_05440 2.08e-81 247.0 COG0270@1|root,COG0270@2|Bacteria,4P351@976|Bacteroidetes,1I9UJ@117743|Flavobacteriia,2NZ0G@237|Flavobacterium 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_365520_1 1235797.C816_04171 3.94e-19 87.8 COG3108@1|root,COG3108@2|Bacteria 2|Bacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_392493_1 159087.Daro_2526 3.78e-26 113.0 COG0582@1|root,COG0582@2|Bacteria,1REK7@1224|Proteobacteria,2VPEX@28216|Betaproteobacteria,2KW3T@206389|Rhodocyclales 206389|Rhodocyclales L phage integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_338843_1 391600.ABRU01000040_gene1802 1.15e-12 73.2 COG3598@1|root,COG3598@2|Bacteria,1QZRH@1224|Proteobacteria,2TYCX@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - Prim-Pol k59_338843_2 391612.CY0110_31410 4.08e-23 92.0 COG2827@1|root,COG2827@2|Bacteria,1GMN6@1117|Cyanobacteria,3KKM0@43988|Cyanothece 1117|Cyanobacteria L GIY-YIG catalytic domain - - - - - - - - - - - - GIY-YIG k59_419369_1 1293048.CBMB010000004_gene2079 3.81e-24 103.0 COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23SHF@183963|Halobacteria 183963|Halobacteria M COG0451 Nucleoside-diphosphate-sugar epimerases - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_406197_5 467481.B0VK49_9CAUD 4.95e-16 88.2 4QBUC@10239|Viruses,4QVRG@35237|dsDNA viruses no RNA stage,4QQGQ@28883|Caudovirales,4QMEK@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_271839_2 345201.ICP46_IIV3 3.98e-05 47.8 4QG5U@10239|Viruses,4QYVP@35237|dsDNA viruses no RNA stage 10239|Viruses S ligase activity - - - - - - - - - - - - - k59_353733_2 195105.CN97_00640 1.07e-41 148.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2U7X4@28211|Alphaproteobacteria 28211|Alphaproteobacteria G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_137937_1 1027273.GZ77_05365 2.32e-32 116.0 2E04N@1|root,32VT5@2|Bacteria,1N310@1224|Proteobacteria,1SQVP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_29694_1 321846.PS417_10005 2.91e-06 51.6 2EPEW@1|root,33H1I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_36,Phage_rep_O k59_205299_11 479431.Namu_2691 1.77e-10 68.9 2FB7W@1|root,343E4@2|Bacteria,2H7W1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_326942_1 696281.Desru_2499 0.00012 52.8 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,260JQ@186807|Peptococcaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_272057_2 1380394.JADL01000004_gene6135 2.91e-24 102.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,2U1P9@28211|Alphaproteobacteria,2JX6C@204441|Rhodospirillales 204441|Rhodospirillales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_342635_1 691965.D4P7I3_9CAUD 1.93e-77 261.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_98778_1 1121382.JQKG01000001_gene2496 2.55e-35 134.0 2CHRY@1|root,30Z9E@2|Bacteria,1WN8T@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus - - - - - - - - - - - - - - - k59_260686_1 1282362.AEAC466_08890 5.03e-08 61.2 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2KFZX@204458|Caulobacterales 204458|Caulobacterales M Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 k59_140686_1 462590.A9J524_BPPYU 1.72e-28 120.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_316443_2 1300345.LF41_7 7.5e-17 80.1 COG0500@1|root,COG2226@2|Bacteria,1RD1J@1224|Proteobacteria,1S8N4@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_58668_2 1121924.ATWH01000001_gene4299 9.59e-17 91.7 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae 201174|Actinobacteria G Repeats in polycystic kidney disease 1 (PKD1) and other proteins wcoG - - - - - - - - - - - Laminin_G_3,PKD k59_218742_16 709991.Odosp_1948 2.96e-28 122.0 COG3969@1|root,COG3969@2|Bacteria,4NJR7@976|Bacteroidetes,2FMUJ@200643|Bacteroidia,22WJU@171551|Porphyromonadaceae 976|Bacteroidetes S Domain of unknown function (DUF3440) - - - - - - - - - - - - DUF3440,PAPS_reduct k59_218742_17 906968.Trebr_0344 2.3e-11 70.1 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation ibrB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_218742_19 285514.JNWO01000003_gene7093 7.44e-35 141.0 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria 201174|Actinobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_218742_20 994479.GL877880_gene3931 2.22e-116 349.0 COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DYY3@85010|Pseudonocardiales 201174|Actinobacteria I PFAM Myo-inositol-1-phosphate synthase ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_218742_29 1223545.GS4_34_00790 7.46e-29 118.0 COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4GBEX@85026|Gordoniaceae 201174|Actinobacteria U Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_218742_36 1157490.EL26_22985 1.99e-70 242.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1TSMG@1239|Firmicutes,4HBFH@91061|Bacilli,279IG@186823|Alicyclobacillaceae 91061|Bacilli S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_218742_42 109760.SPPG_03547T0 3.81e-20 97.1 COG1793@1|root,2QTYC@2759|Eukaryota,38GKG@33154|Opisthokonta,3P0B0@4751|Fungi 4751|Fungi L DNA ligase - - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2,zf-CCHH k59_218742_43 1338011.BD94_1400 3.45e-80 281.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,1HXMT@117743|Flavobacteriia,34Q8W@308865|Elizabethkingia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_263496_1 205876.Q855N6_9CAUD 4.9e-47 160.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_144032_2 1121382.JQKG01000020_gene1185 9.98e-21 93.2 COG0613@1|root,COG0613@2|Bacteria,1WM4D@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PHP-associated - - - - - - - - - - - - PHP,PHP_C k59_101363_1 760117.JN27_12845 7.82e-20 92.8 COG1051@1|root,COG1051@2|Bacteria,1QX1G@1224|Proteobacteria,2VWUH@28216|Betaproteobacteria,477F3@75682|Oxalobacteraceae 28216|Betaproteobacteria F NUDIX domain - - - - - - - - - - - - NUDIX k59_359082_1 879630.E1A1X2_9CAUD 1.93e-47 172.0 4QF57@10239|Viruses,4QVID@35237|dsDNA viruses no RNA stage,4QSP7@28883|Caudovirales,4QIC6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_234470_1 115711.CP_0543 1.9e-21 87.4 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_144034_2 237609.PSAKL28_16060 4.45e-17 80.1 COG3108@1|root,COG3108@2|Bacteria,1N1HE@1224|Proteobacteria,1SCII@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase M15A - - - - - - - - - - - - Peptidase_M15_3 k59_20220_2 345219.Bcoa_3054 4.1e-11 65.9 COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,4HA14@91061|Bacilli,1ZAV9@1386|Bacillus 91061|Bacilli C NADH dehydrogenase yjlD - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - iYO844.BSU12290 Pyr_redox_2 k59_168281_1 586413.CCDL010000004_gene3569 1.42e-69 222.0 COG1196@1|root,COG1196@2|Bacteria,1VEQ8@1239|Firmicutes,4IT5E@91061|Bacilli 91061|Bacilli D nuclear chromosome segregation - - - - - - - - - - - - - k59_359109_1 1609634.A0A0C5AFV4_9VIRU 2.63e-16 83.2 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_330412_1 272942.RCAP_rcc00971 3.22e-26 107.0 28M7D@1|root,2ZAKV@2|Bacteria,1R6BC@1224|Proteobacteria,2U3UN@28211|Alphaproteobacteria,1FCRU@1060|Rhodobacter 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_330412_4 1517681.HW45_02700 7.46e-36 142.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1QZAD@1224|Proteobacteria,1RYP3@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_411669_1 3055.EDP03406 6.37e-17 86.3 COG0553@1|root,KOG1000@2759|Eukaryota,37JEZ@33090|Viridiplantae,34K36@3041|Chlorophyta 3041|Chlorophyta A SNF2 family N-terminal domain - - 3.6.4.12 ko:K14440 - - - - ko00000,ko01000,ko03036 - - - Helicase_C,SNF2_N k59_144426_1 1618243.A0A0C5IAV0_9CIRC 3.39e-16 79.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_144426_2 1618248.A0A0C5IB82_9CIRC 3.44e-19 89.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_20534_1 1121380.JNIW01000043_gene1045 0.000381 48.5 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,HTH_31,N_BRCA1_IG k59_275726_1 1548903.A0A0A1IUA3_9CAUD 6.34e-14 71.2 4QGMN@10239|Viruses,4QT34@28883|Caudovirales,4QIAZ@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_22386_3 459349.CLOAM0490 4.39e-14 71.6 COG3772@1|root,COG3772@2|Bacteria 2|Bacteria S cytolysis by virus of host cell - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_212996_2 691965.D4P7I8_9CAUD 1.08e-51 170.0 4QGJH@10239|Viruses,4QZ35@35237|dsDNA viruses no RNA stage,4QRZS@28883|Caudovirales,4QMAA@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_291461_1 1536592.A0A088FB29_9VIRU 7.67e-91 276.0 4QB5I@10239|Viruses 10239|Viruses S N-methyltransferase activity - - - - - - - - - - - - - k59_331897_2 1123020.AUIE01000007_gene3229 2.47e-25 103.0 2CJWY@1|root,31CWF@2|Bacteria,1RKEF@1224|Proteobacteria,1S75P@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_384246_1 1465751.W8R9Q8_9VIRU 3.48e-51 167.0 4QAQH@10239|Viruses,4QV9Y@35237|dsDNA viruses no RNA stage 10239|Viruses S phosphatase activity - GO:0005575,GO:0018995,GO:0030430,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0043656,GO:0043657,GO:0044165,GO:0044168,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_384441_1 935565.JAEM01000023_gene1676 5.9e-107 366.0 COG4733@1|root,COG4733@2|Bacteria,1Q2WW@1224|Proteobacteria,2TUS9@28211|Alphaproteobacteria,2PYKS@265|Paracoccus 28211|Alphaproteobacteria S Phage-related protein, tail component - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_265930_1 1465751.W8QMX7_9VIRU 9.8e-11 58.5 4QCNV@10239|Viruses,4QUPJ@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_265930_2 1465751.W8QE71_9VIRU 1.24e-54 178.0 4QHKN@10239|Viruses,4R0A1@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_213319_3 691965.D4P7D9_9CAUD 2.43e-85 261.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_213319_4 428125.CLOLEP_01417 6.76e-21 89.4 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,3WMXK@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_36542_1 1385658.U5KPZ6_9VIRU 1.68e-58 200.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_277640_1 1051675.G0YQF5_9CAUD 2.85e-164 505.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_62772_1 485913.Krac_2891 3.51e-06 50.8 2ET1Y@1|root,33KK4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_213331_1 118163.Ple7327_0811 3.39e-23 97.8 COG0468@1|root,COG0468@2|Bacteria,1G14C@1117|Cyanobacteria,3VIWZ@52604|Pleurocapsales 1117|Cyanobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_307803_2 742740.HMPREF9474_02271 3.02e-06 50.8 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,221RR@1506553|Lachnoclostridium 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_10264_1 1128073.G9LQV6_9CIRC 2.2e-159 456.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_10264_2 1128073.G9LQV7_9CIRC 2.72e-40 142.0 4QBIP@10239|Viruses,4QUKB@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_385673_1 345201.VF179_IIV3 2.63e-16 82.4 4QB98@10239|Viruses,4QWE3@35237|dsDNA viruses no RNA stage 10239|Viruses S Glycosyl transferase family 90 - - - - - - - - - - - - - k59_160145_2 391625.PPSIR1_23574 4.13e-23 97.1 COG4021@1|root,COG4021@2|Bacteria,1MX0R@1224|Proteobacteria,438D3@68525|delta/epsilon subdivisions,2X3N9@28221|Deltaproteobacteria,2YWMN@29|Myxococcales 28221|Deltaproteobacteria S tRNAHis guanylyltransferase - - - - - - - - - - - - Thg1,Thg1C k59_350662_1 537021.CLIBASIA_00030 1.43e-05 48.5 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,2UNT9@28211|Alphaproteobacteria,4BJFM@82115|Rhizobiaceae 28211|Alphaproteobacteria L COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_350662_2 1449126.JQKL01000006_gene840 9.55e-19 93.2 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia 186801|Clostridia L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_93182_1 665956.HMPREF1032_03054 0.000161 47.0 COG5301@1|root,COG5301@2|Bacteria,1UYV6@1239|Firmicutes,25BV3@186801|Clostridia 1239|Firmicutes G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_237682_1 46234.ANA_C20636 5.91e-73 246.0 COG0286@1|root,COG0286@2|Bacteria,1G119@1117|Cyanobacteria,1HKJ8@1161|Nostocales 1117|Cyanobacteria V N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_223719_1 997884.HMPREF1068_03186 3.93e-36 137.0 COG1783@1|root,COG1783@2|Bacteria,4NHPB@976|Bacteroidetes,2FR95@200643|Bacteroidia,4AP7A@815|Bacteroidaceae 976|Bacteroidetes S Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_172668_2 1235689.K4NWL6_9CAUD 2.59e-41 157.0 4QAY9@10239|Viruses,4QWGZ@35237|dsDNA viruses no RNA stage,4QRJC@28883|Caudovirales,4QP2W@10744|Podoviridae 10744|Podoviridae S DNA primase activity - - - - - - - - - - - - - k59_427718_1 1385658.U5KPZ6_9VIRU 1.85e-27 111.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_427718_3 1385658.U5KNR1_9VIRU 4.03e-74 238.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_427718_7 1385658.U5KPZ6_9VIRU 3.1e-167 488.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_308175_9 663278.Ethha_1762 1.96e-20 91.3 COG4725@1|root,COG4725@2|Bacteria,1TSJV@1239|Firmicutes,248X5@186801|Clostridia,3WHZ6@541000|Ruminococcaceae 186801|Clostridia KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_268125_1 1123487.KB892865_gene1380 4.09e-30 123.0 COG3170@1|root,COG3170@2|Bacteria,1PMRK@1224|Proteobacteria,2W7ZG@28216|Betaproteobacteria,2KZB6@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_388235_2 864051.BurJ1DRAFT_1864 2.51e-23 90.9 2FKIP@1|root,34C5S@2|Bacteria,1P5YE@1224|Proteobacteria 1224|Proteobacteria S R67 dihydrofolate reductase - - - - - - - - - - - - DHFR_2 k59_430614_1 1618236.A0A0C5I2F3_9CIRC 2.44e-40 150.0 4QGVY@10239|Viruses,4QUKN@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_430614_2 1788455.A0A190WHF5_9CIRC 9.9e-23 99.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_336503_1 1117108.PAALTS15_13952 1.55e-10 65.1 COG0431@1|root,COG0431@2|Bacteria,1VI8F@1239|Firmicutes,4HPT0@91061|Bacilli,26US4@186822|Paenibacillaceae 91061|Bacilli S NADPH-dependent FMN reductase azo1 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0052873,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.5.1.36,1.7.1.6 ko:K03206,ko:K19784,ko:K22393 ko00740,ko01100,map00740,map01100 - R05705,R09748,R09750 RC00126 ko00000,ko00001,ko01000 - - - FMN_red k59_377517_2 1206101.AZXC01000031_gene5160 1.87e-05 52.8 COG2189@1|root,COG2189@2|Bacteria,2I8FH@201174|Actinobacteria 201174|Actinobacteria L DNA methylase modB - 2.1.1.72 ko:K00571,ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,TypeIII_RM_meth k59_430638_1 1618238.A0A0C5IB41_9CIRC 2.16e-13 73.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_377633_2 865861.AZSU01000005_gene908 4.08e-54 180.0 COG1351@1|root,COG1351@2|Bacteria,1TRHD@1239|Firmicutes,24AQH@186801|Clostridia 186801|Clostridia F Thymidylate synthase complementing protein - - - - - - - - - - - - Thy1 k59_389799_1 1408422.JHYF01000003_gene951 0.000103 47.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,36EKH@31979|Clostridiaceae 186801|Clostridia L Belongs to the 'phage' integrase family xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase k59_229025_1 1618248.A0A0C5IB82_9CIRC 1.26e-61 205.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_243608_3 1392486.JIAF01000004_gene2652 3.44e-11 65.1 2A8C7@1|root,30XDU@2|Bacteria,4PAU1@976|Bacteroidetes,2FXRV@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_14145_1 1692256.A0A0K1RL85_9CIRC 3.47e-21 98.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_216510_3 580331.Thit_1395 1.74e-39 157.0 COG0507@1|root,COG0507@2|Bacteria,1TQWH@1239|Firmicutes,24A8I@186801|Clostridia,42HVJ@68295|Thermoanaerobacterales 186801|Clostridia L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_405629_1 1120951.AUBG01000002_gene1174 6.49e-18 88.2 COG0358@1|root,COG0358@2|Bacteria,4NEFU@976|Bacteroidetes,1I159@117743|Flavobacteriia 976|Bacteroidetes L COG NOG08810 non supervised orthologous group - - - - - - - - - - - - - k59_41348_1 1201288.M900_0068 9.22e-19 88.2 COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,42P3H@68525|delta/epsilon subdivisions,2WK0J@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_41348_2 643562.Daes_2470 5.99e-09 58.2 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2M8FS@213115|Desulfovibrionales 28221|Deltaproteobacteria S CBS domain containing protein - - - - - - - - - - - - CBS,DUF21 k59_283931_2 118168.MC7420_1532 1.44e-07 52.0 2E0EK@1|root,32W12@2|Bacteria,1G8X2@1117|Cyanobacteria,1HFTN@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_365047_2 142661.REP_CACV 1.02e-22 103.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_229918_1 645512.GCWU000246_00705 1.68e-06 56.2 COG5280@1|root,COG5281@1|root,COG5280@2|Bacteria,COG5281@2|Bacteria,3TC79@508458|Synergistetes 508458|Synergistetes S Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_81778_1 82996.sch_09140 1.32e-19 90.1 COG0640@1|root,COG0640@2|Bacteria,1N0B6@1224|Proteobacteria,1T07U@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_27935_1 1122971.BAME01000119_gene6173 5.91e-13 77.0 COG1196@1|root,COG1196@2|Bacteria,4PMTY@976|Bacteroidetes,2FRJ0@200643|Bacteroidia 976|Bacteroidetes D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_257037_1 1385658.U5KPZ6_9VIRU 1.14e-153 450.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_162635_1 909297.G8CLA3_9CAUD 6.83e-26 111.0 4QAZJ@10239|Viruses,4QX3R@35237|dsDNA viruses no RNA stage,4QPFF@28883|Caudovirales,4QKU7@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein, lambda family - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046798 - - - - - - - - - - - k59_162635_2 1128111.HMPREF0870_01768 1.6e-30 124.0 COG3087@1|root,COG3087@2|Bacteria,1TP8N@1239|Firmicutes,4H403@909932|Negativicutes 909932|Negativicutes D Caudovirus prohead protease - - - - - - - - - - - - Peptidase_S78 k59_175881_1 716541.ECL_01715 4.95e-05 55.5 COG0840@1|root,COG4733@1|root,COG0840@2|Bacteria,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,3X1AZ@547|Enterobacter 1236|Gammaproteobacteria NT Fibronectin type 3 domain - - - - - - - - - - - - DUF1983,DUF3672,Phage-tail_3 k59_418904_2 411483.FAEPRAA2165_02707 1.29e-07 53.9 COG1476@1|root,COG1476@2|Bacteria,1V6AC@1239|Firmicutes,24HZZ@186801|Clostridia,3WJ7W@541000|Ruminococcaceae 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_270657_1 744979.R2A130_3468 3.9e-31 130.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM Phage - - - - - - - - - - - - Terminase_6C k59_270657_2 1358423.N180_02820 3.93e-19 84.3 2E8S0@1|root,3332X@2|Bacteria,4NWIA@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_55405_1 97139.C824_00328 1.02e-37 152.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,36EWE@31979|Clostridiaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_311576_1 1121448.DGI_2054 8.79e-68 214.0 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,42TUH@68525|delta/epsilon subdivisions,2WQCB@28221|Deltaproteobacteria 28221|Deltaproteobacteria OU Serine dehydrogenase proteinase - - - - - - - - - - - - CLP_protease k59_123381_3 753084.F4YCI8_9CAUD 5.59e-12 63.9 4QUTY@35237|dsDNA viruses no RNA stage,4QM17@10699|Siphoviridae 10699|Siphoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_123381_4 1282664.H354_06646 3.75e-19 81.6 2EC8I@1|root,33670@2|Bacteria,1VENI@1239|Firmicutes,4HR98@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_56737_1 2074.JNYD01000013_gene6891 1.98e-15 81.6 COG4695@1|root,COG4695@2|Bacteria,2IE2H@201174|Actinobacteria,4EEDJ@85010|Pseudonocardiales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_29609_1 1449063.JMLS01000030_gene447 2.75e-64 215.0 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,4HD7Q@91061|Bacilli,26VH9@186822|Paenibacillaceae 91061|Bacilli S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_177560_1 1556290.A0A0A0RM05_9CAUD 6.79e-34 133.0 4QAYV@10239|Viruses,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_366658_1 986075.CathTA2_2439 2.26e-55 184.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,4HHQR@91061|Bacilli 91061|Bacilli H C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_366658_2 1121937.AUHJ01000007_gene1914 1.22e-125 370.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,1RY8S@1236|Gammaproteobacteria,468CF@72275|Alteromonadaceae 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Arm-DNA-bind_1,Phage_int_SAM_4,Phage_integrase k59_56742_1 1040986.ATYO01000003_gene5660 1.35e-56 199.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,43I71@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_56742_2 349163.Acry_0957 2.95e-47 165.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,2JQAP@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_353652_2 1618238.A0A0C5IB41_9CIRC 2.58e-31 127.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_137827_11 1173024.KI912153_gene242 5.38e-08 57.4 COG2389@1|root,COG2389@2|Bacteria,1G6XV@1117|Cyanobacteria,1JIH5@1189|Stigonemataceae 1117|Cyanobacteria S Uncharacterized metal-binding protein (DUF2227) - - - - - - - - - - - - DUF2227 k59_137827_13 55601.VANGNB10_cII0465 2.12e-12 63.5 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XYCD@135623|Vibrionales 135623|Vibrionales K Cold shock cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_191100_1 1173762.S4TP25_9CAUD 2.63e-122 377.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_191100_2 942016.E9NIG9_9CAUD 1.61e-83 263.0 4QEG2@10239|Viruses,4QVSD@35237|dsDNA viruses no RNA stage,4QRJ9@28883|Caudovirales,4QP0R@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_191100_4 942016.E9NIH0_9CAUD 4.44e-163 487.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_191100_5 1230338.MOMA_06926 4.63e-29 118.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_355829_1 595593.JREV01000041_gene340 3.62e-06 53.9 COG1404@1|root,COG1404@2|Bacteria,2GJ14@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - CW_binding_1,Peptidase_S8 k59_421630_3 691965.D4P7L7_9CAUD 8.23e-205 606.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_85933_1 215803.DB30_3022 2.25e-08 64.3 COG1520@1|root,COG3420@1|root,COG4733@1|root,COG1520@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,1PEHC@1224|Proteobacteria,437JY@68525|delta/epsilon subdivisions,2X2U0@28221|Deltaproteobacteria,2Z04Z@29|Myxococcales 28221|Deltaproteobacteria P Parallel beta-helix repeats - - - - - - - - - - - - - k59_300948_1 755178.Cyan10605_2626 1.01e-07 58.2 COG3864@1|root,COG3864@2|Bacteria,1G20V@1117|Cyanobacteria 1117|Cyanobacteria S metallopeptidase (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_381025_1 291607.REP6_SCSVF 1.27e-22 102.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_31569_1 1504822.CCNO01000015_gene594 1.94e-66 221.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_286982_1 1095743.HMPREF1054_1770 8.45e-30 120.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RRK4@1236|Gammaproteobacteria,1Y7IC@135625|Pasteurellales 135625|Pasteurellales S Bacteriophage capsid protein - - - - - - - - - - - - Phage_portal_2 k59_140402_1 322855.Q52PN4_9CAUD 2.46e-61 219.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_58479_1 1140.Synpcc7942_0725 1.62e-87 276.0 COG1061@1|root,COG1061@2|Bacteria,1G2HP@1117|Cyanobacteria,1H08U@1129|Synechococcus 1117|Cyanobacteria L Helicase conserved C-terminal domain - - - - - - - - - - - - DUF3427,Helicase_C,ResIII k59_328763_2 1082933.MEA186_20002 4.81e-50 172.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_300963_2 760568.Desku_1126 1.64e-55 187.0 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1TT7N@1239|Firmicutes,24D10@186801|Clostridia 186801|Clostridia L ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_260722_2 1396141.BATP01000047_gene3968 0.000256 50.4 COG3291@1|root,COG3291@2|Bacteria,46XNU@74201|Verrucomicrobia,2IW9Y@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Pkd domain containing protein - - - - - - - - - - - - Laminin_G_3 k59_140715_2 1054460.SPPN_00145 1.64e-07 56.6 2CWXD@1|root,32T0J@2|Bacteria,1V83I@1239|Firmicutes,4HPQE@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_342892_1 626887.J057_01665 9.5e-45 164.0 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,1RR0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_381140_1 1121127.JAFA01000041_gene4289 1.34e-16 90.1 COG3598@1|root,COG3598@2|Bacteria,1R4EA@1224|Proteobacteria,2VKG4@28216|Betaproteobacteria,1K0AY@119060|Burkholderiaceae 28216|Betaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25,PriCT_2 k59_77410_1 926554.KI912617_gene4745 1.04e-15 79.3 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,HTH_31,N_BRCA1_IG k59_370774_1 1121286.AUMT01000013_gene2602 1.58e-51 174.0 29D2S@1|root,3000U@2|Bacteria,4PGQF@976|Bacteroidetes,1IM4Y@117743|Flavobacteriia,3ZSNA@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_370774_2 1300143.CCAV010000006_gene4312 9.21e-107 328.0 COG4653@1|root,COG4653@2|Bacteria,4P9ZK@976|Bacteroidetes,1IM07@117743|Flavobacteriia,3ZTHB@59732|Chryseobacterium 976|Bacteroidetes S Phage capsid family - - - - - - - - - - - - - k59_370774_10 266762.HQ36_02140 1.07e-26 127.0 COG3941@1|root,COG3941@2|Bacteria,4NPQ5@976|Bacteroidetes,2FRTG@200643|Bacteroidia 976|Bacteroidetes S tape measure - - - - - - - - - - - - - k59_370774_11 1144313.PMI10_00661 3.15e-60 220.0 2DNIX@1|root,32XR6@2|Bacteria,4NU21@976|Bacteroidetes,1I3XV@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_330737_1 1236514.BAKL01000015_gene1636 1.18e-05 47.4 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_330737_2 926549.KI421517_gene1289 5.82e-24 99.8 COG3728@1|root,COG3728@2|Bacteria 2|Bacteria L DNA packaging xtmA - - ko:K07474 - - - - ko00000 - - - Terminase_2 k59_211130_1 596154.Alide2_1988 7.69e-137 391.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2VMDZ@28216|Betaproteobacteria,4A9K0@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_61027_14 314230.DSM3645_28792 2.41e-30 138.0 COG1357@1|root,COG1357@2|Bacteria,2J2VS@203682|Planctomycetes 203682|Planctomycetes S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - - k59_264023_1 509635.N824_09870 8.51e-16 85.1 arCOG09486@1|root,2ZC3Y@2|Bacteria,4NNUF@976|Bacteroidetes,1IT11@117747|Sphingobacteriia 976|Bacteroidetes S Glycosyl transferase family 11 - - - - - - - - - - - - Glyco_transf_11 k59_127398_2 648250.VNCS_JDNVP 1.48e-52 179.0 4QAUG@10239|Viruses,4QUM5@29258|ssDNA viruses 10239|Viruses L Parvovirus non-structural protein NS1 - GO:0001906,GO:0001907,GO:0005575,GO:0008150,GO:0009889,GO:0010556,GO:0010941,GO:0010942,GO:0016032,GO:0018995,GO:0019048,GO:0019051,GO:0019054,GO:0019056,GO:0019058,GO:0019079,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031341,GO:0031343,GO:0031640,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0035821,GO:0039526,GO:0039592,GO:0039656,GO:0039685,GO:0039693,GO:0042025,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044071,GO:0044215,GO:0044216,GO:0044217,GO:0044364,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0044533,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051726,GO:0051817,GO:0051818,GO:0051883,GO:0052026,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052312,GO:0052330,GO:0052433,GO:0052501,GO:0060139,GO:0060153,GO:0060255,GO:0065007,GO:0080090,GO:2001141 - - - - - - - - - - - k59_265877_3 237368.SCABRO_04002 1.36e-06 55.1 COG3343@1|root,COG4733@1|root,COG3343@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - DUF285,PA14,TSP_3,VCBS,fn3 k59_305935_1 1123248.KB893326_gene1444 1.16e-05 53.5 COG1749@1|root,COG2372@1|root,COG4625@1|root,COG5184@1|root,COG1749@2|Bacteria,COG2372@2|Bacteria,COG4625@2|Bacteria,COG5184@2|Bacteria,4NTUT@976|Bacteroidetes 976|Bacteroidetes N Domain of unknown function (DUF4082) - - - - - - - - - - - - Cu-binding_MopE,DUF4082 k59_236290_1 321846.PS417_10005 1.74e-07 59.3 2EPEW@1|root,33H1I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_36,Phage_rep_O k59_8578_1 1268072.PSAB_06020 2.43e-13 73.9 COG0175@1|root,COG0175@2|Bacteria,1TQBQ@1239|Firmicutes,4HD3W@91061|Bacilli,270CN@186822|Paenibacillaceae 91061|Bacilli EH sulfate reduction - - - - - - - - - - - - - k59_170049_1 883078.HMPREF9695_01543 2.48e-40 152.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3JRJJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_277583_1 1692262.A0A0K1RL89_9CIRC 2.48e-25 104.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_384418_1 856793.MICA_542 3.97e-46 151.0 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,2UDAG@28211|Alphaproteobacteria,4BSF4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S D-alanyl-D-alanine carboxypeptidase - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_147569_1 857087.Metme_2122 6.68e-10 65.5 COG1073@1|root,COG1073@2|Bacteria,1R9V1@1224|Proteobacteria,1S4ZD@1236|Gammaproteobacteria,1XG0S@135618|Methylococcales 135618|Methylococcales S alpha beta - - - - - - - - - - - - - k59_22649_1 1121441.AUCX01000016_gene2309 2.4e-09 64.7 COG0438@1|root,COG1215@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,1QUJX@1224|Proteobacteria,42VVR@68525|delta/epsilon subdivisions,2X6XK@28221|Deltaproteobacteria,2MCCT@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_1,Glycos_transf_2 k59_291782_1 1204521.I6ZXZ4_9CAUD 1.78e-40 148.0 4QHBE@10239|Viruses,4QT2W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_305955_2 706434.HMPREF9429_00659 0.000503 43.1 COG5295@1|root,COG5295@2|Bacteria,1VSGR@1239|Firmicutes,4H6J4@909932|Negativicutes 909932|Negativicutes UW Hep Hag repeat protein - - - - - - - - - - - - ESPR,YadA_anchor,YadA_head,YadA_stalk k59_322099_2 264462.Bd1130 2.61e-05 56.6 COG3209@1|root,COG3209@2|Bacteria,1QY1R@1224|Proteobacteria,43C93@68525|delta/epsilon subdivisions,2MUT2@213481|Bdellovibrionales,2X7JI@28221|Deltaproteobacteria 213481|Bdellovibrionales M cell wall surface anchor family protein - - - - - - - - - - - - Peptidase_S74 k59_291784_2 749222.Nitsa_1815 2.92e-29 111.0 2AMKF@1|root,31CGC@2|Bacteria,1Q8QE@1224|Proteobacteria,4327D@68525|delta/epsilon subdivisions,2YSNP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_103532_2 42565.FP66_04575 2.82e-21 91.7 2ECFT@1|root,336E2@2|Bacteria,1NDA7@1224|Proteobacteria,1STRT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_103532_4 1121943.KB900008_gene1991 1.19e-70 259.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1R97W@1224|Proteobacteria 1224|Proteobacteria D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_103532_9 1288494.EBAPG3_15220 4.68e-32 118.0 COG3405@1|root,COG3405@2|Bacteria,1QZE5@1224|Proteobacteria,2W62R@28216|Betaproteobacteria 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - k59_361949_1 551789.ATVJ01000003_gene38 9.55e-06 47.8 2CKQA@1|root,30TFE@2|Bacteria,1PD9A@1224|Proteobacteria,2VA61@28211|Alphaproteobacteria,440HH@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_266079_2 1133022.I6NST0_9CAUD 1.89e-09 63.5 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_348168_1 90371.CY43_01915 4.36e-37 147.0 2DPZ4@1|root,32UN5@2|Bacteria,1N6B8@1224|Proteobacteria,1SB8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_197293_2 675635.Psed_1230 2.46e-58 197.0 COG0175@1|root,COG0175@2|Bacteria,2IBEQ@201174|Actinobacteria,4E8RB@85010|Pseudonocardiales 201174|Actinobacteria EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_236437_1 1054460.SPPN_00145 4.3e-06 53.1 2CWXD@1|root,32T0J@2|Bacteria,1V83I@1239|Firmicutes,4HPQE@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_362129_1 1327982.R9ZZE9_9CAUD 1.18e-32 137.0 4QGM3@10239|Viruses,4QYG4@35237|dsDNA viruses no RNA stage,4QPTC@28883|Caudovirales,4QMVS@10699|Siphoviridae 10699|Siphoviridae S oxidoreductase activity - - - - - - - - - - - - - k59_157902_1 1173026.Glo7428_1347 1.6e-22 96.3 COG0175@1|root,COG0175@2|Bacteria,1G3GS@1117|Cyanobacteria 1117|Cyanobacteria EH COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase - - - - - - - - - - - - PAPS_reduct k59_185760_2 744979.R2A130_2473 1.05e-16 77.4 2DMHT@1|root,32RN3@2|Bacteria,1N0KK@1224|Proteobacteria,2UCFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - MA20_36130 - - - - - - - - - - - PEGA k59_172748_1 203122.Sde_1925 2.35e-16 85.9 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,1RSQN@1236|Gammaproteobacteria,465EQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Helicase conserved C-terminal domain VPA1393 - - - - - - - - - - - Helicase_C,ResIII k59_427754_2 269482.Bcep1808_4568 3.6e-27 110.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_Tnp_1,HTH_Tnp_IS630 k59_172755_1 768710.DesyoDRAFT_0592 6.35e-37 137.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,260QV@186807|Peptococcaceae 186801|Clostridia O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_374020_1 313624.NSP_51820 4.61e-07 58.5 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - Beta_helix,DUF1565,Laminin_G_3,Metallophos k59_237916_1 691965.D4P7I3_9CAUD 1.13e-170 524.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_200211_1 1234888.K0A2J2_9VIRU 3.58e-40 148.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_160609_2 1463864.JOGO01000036_gene2534 1.94e-43 151.0 COG0073@1|root,COG0073@2|Bacteria,2IMWW@201174|Actinobacteria 201174|Actinobacteria J RNA ligase - - - - - - - - - - - - RNA_ligase k59_428056_1 1046625.AFQY01000003_gene2225 1.12e-46 167.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RPEK@1236|Gammaproteobacteria,3NMHD@468|Moraxellaceae 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_132643_1 1121447.JONL01000012_gene3405 2.01e-61 223.0 COG0503@1|root,COG2518@1|root,COG0503@2|Bacteria,COG2518@2|Bacteria 2|Bacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins apt - 2.1.1.163,2.1.1.201,2.1.1.77,2.4.2.7 ko:K00573,ko:K00759,ko:K03183,ko:K07003 ko00130,ko00230,ko01100,ko01110,map00130,map00230,map01100,map01110 M00116,M00117 R00190,R01229,R04378,R04990,R04993,R06859,R08774,R09736 RC00003,RC00063,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000,ko04147 - - - DUF3560,Methyltransf_21,Pribosyltran k59_173111_2 1096546.WYO_0193 1.27e-77 247.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria 1224|Proteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_25153_1 1548905.A0A0A1IX16_9CAUD 2.75e-45 158.0 4QBTT@10239|Viruses,4QQUU@28883|Caudovirales,4QKWB@10699|Siphoviridae 10699|Siphoviridae S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - - k59_25154_1 1121875.KB907551_gene988 1.08e-31 118.0 COG4422@1|root,COG4422@2|Bacteria,4NJKJ@976|Bacteroidetes,1I0JM@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF5131) - - - - - - - - - - - - DUF5131 k59_268546_1 74547.PMT_0107 1.66e-08 57.8 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - BcsB,Glycos_transf_2,GtrA,Methyltransf_23,Methyltransf_24 k59_10942_1 1541960.KQ78_01196 2.37e-10 62.0 28MKK@1|root,2ZAWR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - RNA_helicase,Viral_Rep k59_390108_2 566552.BIFCAT_00222 1.58e-30 128.0 COG4695@1|root,COG4695@2|Bacteria,2IE2H@201174|Actinobacteria,4CZUZ@85004|Bifidobacteriales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_229251_2 1692249.A0A0K1RL40_9CIRC 4.47e-40 147.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_431020_1 1122604.JONR01000002_gene1622 8.77e-87 281.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1X4NM@135614|Xanthomonadales 135614|Xanthomonadales C E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_229273_3 1692244.A0A0K1RLR5_9CIRC 1.37e-86 266.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_431032_2 1618247.A0A0C5IMK7_9CIRC 0.000107 50.4 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_390160_1 742733.HMPREF9469_05020 1.19e-87 290.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_390188_1 159087.Daro_2679 1.29e-50 176.0 COG2404@1|root,COG2404@2|Bacteria,1MXEH@1224|Proteobacteria,2VKWK@28216|Betaproteobacteria,2KX23@206389|Rhodocyclales 206389|Rhodocyclales S Phosphoesterase DHHA1 - - - - - - - - - - - - DHHA1 k59_241910_1 1237500.ANBA01000003_gene4740 1.19e-37 143.0 COG4653@1|root,COG4653@2|Bacteria,2I9AZ@201174|Actinobacteria 201174|Actinobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_229337_7 398578.Daci_1946 2.73e-23 105.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2W259@28216|Betaproteobacteria 28216|Betaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_229337_12 450851.PHZ_c2212 7.71e-21 100.0 COG5323@1|root,COG5323@2|Bacteria,1R0EP@1224|Proteobacteria,2TYQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - - k59_377797_1 1136535.I6NRM9_9CAUD 1.25e-10 69.7 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_203934_77 1159488.SEQMU2_10595 3.89e-06 57.0 COG0739@1|root,COG0739@2|Bacteria,1UYWU@1239|Firmicutes,4IPIR@91061|Bacilli,4GXRH@90964|Staphylococcaceae 91061|Bacilli M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_203934_80 926569.ANT_19080 2.95e-05 54.3 COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi 200795|Chloroflexi L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_244319_2 1144672.F966_03620 5.55e-18 85.5 2DQ1Q@1|root,334DT@2|Bacteria,1NF0I@1224|Proteobacteria,1RT59@1236|Gammaproteobacteria,3NS93@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_244319_3 1429767.W6B150_9CAUD 7.97e-25 105.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_406160_1 948071.S4S2L2_9CAUD 3.32e-11 73.9 4QHQ5@10239|Viruses,4QR7K@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_216969_17 553217.ENHAE0001_1259 2.34e-11 74.7 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,3NK2H@468|Moraxellaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_419436_2 665956.HMPREF1032_00664 7.53e-65 204.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,3WNNS@541000|Ruminococcaceae 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_42000_1 1795988.A0A140CTK3_9VIRU 3.12e-13 75.1 4QB6C@10239|Viruses 10239|Viruses L Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_109308_1 1123242.JH636435_gene1324 1.88e-34 130.0 COG1216@1|root,COG1216@2|Bacteria,2J4IM@203682|Planctomycetes 203682|Planctomycetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_365691_2 398525.KB900701_gene5093 8.19e-07 55.8 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,3JYHN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_365691_4 358220.C380_12140 3.87e-124 380.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_204065_1 105420.BBPO01000032_gene6576 6.5e-16 77.8 COG1403@1|root,COG1403@2|Bacteria,2GMJV@201174|Actinobacteria,2NHE5@228398|Streptacidiphilus 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_419441_1 46234.ANA_C20636 1e-151 457.0 COG0286@1|root,COG0286@2|Bacteria,1G119@1117|Cyanobacteria,1HKJ8@1161|Nostocales 1117|Cyanobacteria V N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_42005_2 1034345.CAEM01000017_gene1595 0.000359 44.3 COG1396@1|root,COG1396@2|Bacteria,2HVCA@201174|Actinobacteria,4CWNB@84998|Coriobacteriia 84998|Coriobacteriia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_325505_1 1204521.I7B2R4_9CAUD 2.51e-55 183.0 4QF3X@10239|Viruses,4QWSV@35237|dsDNA viruses no RNA stage,4QT5P@28883|Caudovirales 28883|Caudovirales S oxidoreductase activity - - - - - - - - - - - - - k59_325505_3 411465.PEPMIC_01335 5.51e-08 60.1 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,22GBR@1570339|Peptoniphilaceae 186801|Clostridia L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K02342,ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_325505_4 1204521.I7A8M7_9CAUD 2.58e-212 641.0 4QCZC@10239|Viruses,4QX3V@35237|dsDNA viruses no RNA stage,4QRH3@28883|Caudovirales,4QHVR@10662|Myoviridae 10662|Myoviridae S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_28719_4 388413.ALPR1_10925 1.65e-07 55.1 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,47JB5@768503|Cytophagia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_164525_2 1458697.W6EC34_9CAUD 1.35e-16 77.4 4QEGD@10239|Viruses,4QVU1@35237|dsDNA viruses no RNA stage,4QPN9@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_164525_3 883112.HMPREF9707_01629 3.2e-05 50.8 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,4HCNN@91061|Bacilli 91061|Bacilli L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_2900_2 1244856.K4PY64_9CAUD 3.61e-50 176.0 4QF06@10239|Viruses,4QVMB@35237|dsDNA viruses no RNA stage,4QPRV@28883|Caudovirales,4QP2V@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_259263_1 1123487.KB892857_gene2484 9.23e-06 48.9 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,2KUF0@206389|Rhodocyclales 206389|Rhodocyclales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_259263_2 1340713.S5Z352_9CAUD 1.64e-18 85.9 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_327520_1 765698.Mesci_3833 0.000228 50.8 COG4675@1|root,COG4675@2|Bacteria,1QWQH@1224|Proteobacteria,2UUR5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S tail collar domain protein - - - - - - - - - - - - Collar k59_138829_4 879310.HMPREF9162_1719 9.96e-26 110.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes 1239|Firmicutes L snf2 family - - - - - - - - - - - - SNF2_N k59_407914_1 1122201.AUAZ01000026_gene1209 1.14e-72 232.0 2C6N9@1|root,32RHI@2|Bacteria,1P488@1224|Proteobacteria,1SUTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_407914_2 1406780.U5PW18_9CAUD 9.57e-47 171.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_178360_1 585.DR95_340 0.000116 49.3 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558,ko:K17398 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_341311_3 335283.Neut_1460 1.32e-11 67.4 COG1196@1|root,COG1345@1|root,COG1196@2|Bacteria,COG1345@2|Bacteria,1PDRQ@1224|Proteobacteria,2W14R@28216|Betaproteobacteria 28216|Betaproteobacteria D Prophage tail length tape measure protein - - - - - - - - - - - - TMP_2 k59_367364_3 1121937.AUHJ01000007_gene1928 4.23e-48 159.0 2CJKM@1|root,314EI@2|Bacteria,1N8C9@1224|Proteobacteria,1SGI2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_367364_4 1484157.PSNIH2_13450 5.85e-44 151.0 COG1403@1|root,COG1403@2|Bacteria,1N3CX@1224|Proteobacteria,1S45B@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Bacteriophage Lambda NinG protein - - - - - - - - - - - - NinG k59_367364_5 255131.Q6JIG5_9CAUD 2.74e-62 195.0 4QC6A@10239|Viruses,4QWAW@35237|dsDNA viruses no RNA stage,4QPWF@28883|Caudovirales,4QMHG@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_272419_1 1086011.HJ01_03376 2.94e-16 80.9 COG0582@1|root,COG0582@2|Bacteria,4PKC8@976|Bacteroidetes,1HYZC@117743|Flavobacteriia,2NVFN@237|Flavobacterium 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase k59_178379_1 691965.D4P7D6_9CAUD 3.85e-48 174.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_138852_1 446466.Cfla_1527 2.56e-36 135.0 COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4F25M@85016|Cellulomonadaceae 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_246051_1 673375.C9EHE8_9CAUD 2.86e-25 110.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QKNC@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_86865_6 398512.JQKC01000005_gene5461 1.82e-27 128.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,3WH3F@541000|Ruminococcaceae 186801|Clostridia E Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail,TMP k59_261743_2 1540095.A0A0A0YTT7_9CAUD 0.000137 48.9 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - GO:0005575,GO:0019012 - - - - - - - - - - - k59_274072_2 1123288.SOV_6c01570 1.09e-12 66.2 COG1591@1|root,COG1591@2|Bacteria,1U60M@1239|Firmicutes,4H8UA@909932|Negativicutes 909932|Negativicutes L VRR_NUC - - - - - - - - - - - - - k59_422369_2 1344012.ATMI01000056_gene1749 0.000332 50.4 2DNU8@1|root,32Z5M@2|Bacteria,1RGT6@1224|Proteobacteria,1S5HA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Peptidase_S74 k59_274075_1 1121004.ATVC01000036_gene2322 2.14e-27 115.0 COG2401@1|root,COG2401@2|Bacteria,1R423@1224|Proteobacteria,2VTGK@28216|Betaproteobacteria,2KSYZ@206351|Neisseriales 206351|Neisseriales - - - - - - - - - - - - - - - k59_233254_2 343509.SG0734 1.41e-14 72.4 2ECRE@1|root,336P5@2|Bacteria,1N8X3@1224|Proteobacteria,1SG2F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_287849_2 272943.RSP_2994 0.00088 47.8 COG2911@1|root,COG2911@2|Bacteria,1QU6S@1224|Proteobacteria 1224|Proteobacteria D tail tape measure protein - - - - - - - - - - - - SLT,Tape_meas_lam_C k59_18902_3 1125863.JAFN01000001_gene3560 2.04e-35 126.0 2E5ZV@1|root,330P8@2|Bacteria,1NFRE@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_233421_1 1120936.KB907208_gene1107 4.24e-83 267.0 COG0209@1|root,COG0209@2|Bacteria,2IC1H@201174|Actinobacteria 201174|Actinobacteria F Ribonucleotide reductase, barrel domain - - - - - - - - - - - - Ribonuc_red_lgC k59_156260_2 1609634.A0A0C5AFV4_9VIRU 2.11e-41 150.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_220912_2 994573.T472_0207855 2.36e-08 63.5 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia,36DKS@31979|Clostridiaceae 186801|Clostridia L helicase - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII k59_61602_2 749222.Nitsa_1876 4.96e-18 82.4 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42RN6@68525|delta/epsilon subdivisions,2YP9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_35514_1 702450.CUW_0019 6.92e-27 107.0 COG3774@1|root,COG3774@2|Bacteria,1V3YG@1239|Firmicutes,3VR8W@526524|Erysipelotrichia 526524|Erysipelotrichia M Glycosyltransferase sugar-binding region containing DXD motif - - - - - - - - - - - - Gly_transf_sug k59_360763_1 1123020.AUIE01000036_gene2667 9.28e-51 181.0 COG0497@1|root,COG0497@2|Bacteria,1QUIQ@1224|Proteobacteria 1224|Proteobacteria L DNA recombination - - - - - - - - - - - - AAA_21,AAA_23 k59_35520_1 1217658.F987_00327 2.41e-20 90.9 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1SA7C@1236|Gammaproteobacteria,3NSKU@468|Moraxellaceae 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_90057_1 1109717.G9FGV8_9CAUD 1.74e-11 69.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_221103_2 1265310.CCBD010000019_gene4070 0.00093 48.9 COG0582@1|root,COG0582@2|Bacteria,2I2P9@201174|Actinobacteria,238VB@1762|Mycobacteriaceae 201174|Actinobacteria L to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_90061_1 107636.JQNK01000009_gene1966 6.01e-14 78.6 2C5MK@1|root,3010G@2|Bacteria,1RA3G@1224|Proteobacteria,2U6GP@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_384980_2 870187.Thini_0411 5.97e-25 108.0 2EP1Y@1|root,33GNT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_91959_1 1449355.JQNR01000005_gene3191 6.98e-06 53.9 COG0797@1|root,COG5297@1|root,COG0797@2|Bacteria,COG5297@2|Bacteria,2IBUB@201174|Actinobacteria 201174|Actinobacteria M Lytic transglycolase - - - - - - - - - - - - DPBB_1 k59_323294_1 665956.HMPREF1032_00672 2.6e-167 486.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_184575_2 439375.Oant_0254 1.72e-12 67.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2UMWB@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_198264_1 1264700.L0MYG2_9CAUD 3.56e-30 115.0 4QAYT@10239|Viruses,4QVA1@35237|dsDNA viruses no RNA stage,4QPXH@28883|Caudovirales,4QI47@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF3383) - - - - - - - - - - - - - k59_198264_2 551895.B5AX66_9CAUD 6.73e-64 198.0 4QF2C@10239|Viruses,4QV1K@35237|dsDNA viruses no RNA stage,4QRT1@28883|Caudovirales,4QKIX@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_198265_1 765869.BDW_02245 6.98e-08 58.9 COG3291@1|root,COG3291@2|Bacteria,1RCXG@1224|Proteobacteria,42SKT@68525|delta/epsilon subdivisions,2X89X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Mycoplasma protein of unknown function, DUF285 - - - - - - - - - - - - DUF285 k59_236903_2 365046.Rta_12630 5.12e-27 116.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs-related protein - - - - - - - - - - - - RHS,RHS_repeat k59_306940_4 938709.AUSH02000045_gene357 0.000603 52.4 COG1361@1|root,COG1506@1|root,COG2304@1|root,COG2374@1|root,COG3209@1|root,COG3391@1|root,COG4886@1|root,COG5184@1|root,COG1361@2|Bacteria,COG1506@2|Bacteria,COG2304@2|Bacteria,COG2374@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity rapB1 - 1.14.17.3,3.2.1.8 ko:K00504,ko:K01181,ko:K06889,ko:K07004,ko:K12548 - - - - ko00000,ko01000 - - - CHU_C,DUF11 k59_400041_2 285514.JNWO01000012_gene6665 3.29e-25 103.0 COG1475@1|root,COG1475@2|Bacteria,2GMF3@201174|Actinobacteria 201174|Actinobacteria K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_363208_2 926562.Oweho_0361 0.000285 42.4 COG3108@1|root,COG3108@2|Bacteria,4NSZA@976|Bacteroidetes,1I46U@117743|Flavobacteriia 976|Bacteroidetes S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_171220_1 753085.F4YCV3_9CAUD 1.24e-153 459.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_236915_1 5827.XP_004224326.1 1.5e-31 128.0 COG0187@1|root,KOG0355@2759|Eukaryota,3Y9T6@5794|Apicomplexa,3KBXJ@422676|Aconoidasida,3YZC4@5819|Haemosporida 422676|Aconoidasida B Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks - GO:0000003,GO:0000075,GO:0000278,GO:0000280,GO:0000287,GO:0000712,GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003824,GO:0003916,GO:0003918,GO:0005080,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0006139,GO:0006259,GO:0006265,GO:0006266,GO:0006310,GO:0006323,GO:0006725,GO:0006807,GO:0006915,GO:0006921,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007093,GO:0007127,GO:0007131,GO:0007346,GO:0008022,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0008301,GO:0009330,GO:0009987,GO:0010639,GO:0010941,GO:0010942,GO:0012501,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0019899,GO:0019900,GO:0019901,GO:0022402,GO:0022411,GO:0022414,GO:0030261,GO:0030262,GO:0030263,GO:0031570,GO:0031974,GO:0031981,GO:0032182,GO:0032991,GO:0033043,GO:0033044,GO:0033554,GO:0034641,GO:0035825,GO:0042623,GO:0042752,GO:0042802,GO:0042803,GO:0042826,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043130,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043900,GO:0043902,GO:0043903,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044774,GO:0045069,GO:0045070,GO:0045091,GO:0045132,GO:0045786,GO:0045870,GO:0045930,GO:0046483,GO:0046872,GO:0046982,GO:0046983,GO:0048285,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051276,GO:0051304,GO:0051307,GO:0051321,GO:0051716,GO:0051726,GO:0061505,GO:0061982,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097194,GO:0098813,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046,GO:1903047,GO:1903900,GO:1903902,GO:1905462,GO:1905463,GO:1990904,GO:2001251 5.99.1.3 ko:K03164 ko01524,map01524 - - - ko00000,ko00001,ko01000,ko03032,ko03036 - - - DNA_gyraseB,DNA_topoisoIV,HATPase_c,TOPRIM_C,Toprim k59_426643_1 3694.POPTR_0013s05600.1 2.27e-06 53.1 COG1403@1|root,2QQI3@2759|Eukaryota,37PXC@33090|Viridiplantae,3GEP1@35493|Streptophyta,4JGIF@91835|fabids 35493|Streptophyta V HNH endonuclease - - - - - - - - - - - - HNH_5 k59_332634_1 1042377.AFPJ01000015_gene1613 0.000105 52.8 COG1040@1|root,COG1040@2|Bacteria,1QV41@1224|Proteobacteria,1RSAP@1236|Gammaproteobacteria,4651C@72275|Alteromonadaceae 1236|Gammaproteobacteria S competence protein - - - - - - - - - - - - - k59_400044_1 1234880.K0A2H8_9CIRC 6.33e-83 256.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_252342_1 1618248.A0A0C5IB82_9CIRC 1.09e-21 99.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_9479_3 1122613.ATUP01000001_gene2228 7.54e-09 60.5 COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,2TT15@28211|Alphaproteobacteria,440Q7@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Cell Wall Hydrolase sleB - - - - - - - - - - - Hydrolase_2 k59_400243_2 69395.JQLZ01000005_gene3625 7.81e-15 83.6 COG3866@1|root,COG3866@2|Bacteria,1MUT3@1224|Proteobacteria,2U08U@28211|Alphaproteobacteria 28211|Alphaproteobacteria G pectate lyase - - - - - - - - - - - - Pec_lyase_C k59_349391_1 1121445.ATUZ01000011_gene824 1.85e-13 75.5 COG3170@1|root,COG3170@2|Bacteria,1QZU8@1224|Proteobacteria,43CP9@68525|delta/epsilon subdivisions,2X7WK@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_52751_1 288000.BBta_5780 1.16e-10 61.2 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria,3K04T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_25803_1 1229780.BN381_430072 3.1e-59 208.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,3UWBK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L DNA polymerase alpha chain like domain dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_118811_1 113395.AXAI01000008_gene767 1.18e-33 132.0 COG4695@1|root,COG4695@2|Bacteria,1R85T@1224|Proteobacteria 1224|Proteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_428607_1 1450525.JATV01000008_gene570 8.41e-07 55.5 COG1216@1|root,COG1216@2|Bacteria,4P2PS@976|Bacteroidetes,1IDN8@117743|Flavobacteriia,2NYTW@237|Flavobacterium 976|Bacteroidetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_4 k59_39686_1 1175654.A0A0S0N2N8_9CAUD 3.01e-20 82.4 4QGE9@10239|Viruses,4QVDG@35237|dsDNA viruses no RNA stage,4QS71@28883|Caudovirales,4QMTZ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_39686_2 1538804.A0A088F6U0_9CAUD 3.4e-14 67.0 4QGKT@10239|Viruses,4QSD6@28883|Caudovirales,4QN8H@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_39686_3 1538804.A0A088FAR2_9CAUD 6.85e-36 141.0 4QAQ9@10239|Viruses,4QPTV@28883|Caudovirales,4QKRS@10699|Siphoviridae 10699|Siphoviridae S Putative phage tail protein - GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044406,GO:0044419,GO:0044650,GO:0051704 - - - - - - - - - - - k59_133544_1 1121324.CLIT_2c02880 4.57e-78 242.0 COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,2497R@186801|Clostridia 186801|Clostridia S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_186692_1 1161935.H9D1G9_9CAUD 1.31e-30 121.0 4QAIV@10239|Viruses,4QYFZ@35237|dsDNA viruses no RNA stage,4QSMH@28883|Caudovirales,4QNFF@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_106701_1 649747.HMPREF0083_05323 3.21e-14 77.8 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli,26W69@186822|Paenibacillaceae 91061|Bacilli L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_133873_1 1380355.JNIJ01000008_gene2003 3.17e-27 108.0 COG4974@1|root,COG4974@2|Bacteria,1QV9T@1224|Proteobacteria,2UBC9@28211|Alphaproteobacteria,3K26N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Phage integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_351234_1 1173762.S4TNV6_9CAUD 1.12e-95 301.0 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_256728_1 1204516.I6X7V5_9CAUD 4.57e-21 96.7 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QI9Y@10662|Myoviridae 10662|Myoviridae S ATPase family associated with various cellular activities (AAA) - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_256728_5 1283340.Q6WI78_BPKVM 3.32e-31 137.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_256728_6 279006.Q6J2Q5_9CAUD 1.19e-37 145.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_256728_7 1283076.M1HLV2_9CAUD 1.23e-24 101.0 4QC5H@10239|Viruses,4QVHT@35237|dsDNA viruses no RNA stage,4QPNZ@28883|Caudovirales,4QIPU@10662|Myoviridae 10662|Myoviridae S sigma factor activity - - - - - - - - - - - - - k59_256728_8 1026955.F5B3R7_9CAUD 5.57e-93 298.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage 10239|Viruses S N-methyltransferase activity - - - - - - - - - - - - - k59_256728_17 1548903.A0A0A1IWP9_9CAUD 3.79e-71 233.0 4QCM7@10239|Viruses,4QPQ5@28883|Caudovirales,4QIHM@10662|Myoviridae 10662|Myoviridae S RNA ligase - - - - - - - - - - - - - k59_256728_21 314607.KB13_656 3.06e-47 157.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,1KQ17@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_203023_1 1042876.PPS_1292 2.67e-17 82.0 COG3091@1|root,COG3091@2|Bacteria,1N07A@1224|Proteobacteria,1S9E8@1236|Gammaproteobacteria,1YYFT@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Belongs to the SprT family sprT - - ko:K02742 - - - - ko00000 - - - SprT-like,Zn_ribbon_SprT k59_243241_7 1122927.KB895420_gene4226 3.27e-25 109.0 COG3541@1|root,COG3541@2|Bacteria,1TT57@1239|Firmicutes,4HD38@91061|Bacilli,26RAT@186822|Paenibacillaceae 91061|Bacilli S Predicted nucleotidyltransferase ycgL - - ko:K07074 - - - - ko00000 - - - Nuc-transf k59_108319_2 411460.RUMTOR_01358 1.26e-36 126.0 2CGGB@1|root,32UNH@2|Bacteria,1VD9W@1239|Firmicutes,24MWC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_108319_3 881953.E0YIS7_9CAUD 1.01e-07 56.6 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_270239_1 1217656.F964_00566 1.08e-49 171.0 COG3935@1|root,COG3935@2|Bacteria,1N2SH@1224|Proteobacteria,1SBMX@1236|Gammaproteobacteria,3NTFF@468|Moraxellaceae 1236|Gammaproteobacteria L DnaD domain protein - - - - - - - - - - - - - k59_337676_2 1498011.A0A096XUY1_9CAUD 3.55e-66 216.0 4QHBE@10239|Viruses,4QT2W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_216969_8 10752.A0MZB4_BPN4 5.18e-14 80.5 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QNDS@10744|Podoviridae 10744|Podoviridae S ATPase activity - - - - - - - - - - - - - k59_216969_9 1322246.BN4_20101 1.09e-19 98.2 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2WM78@28221|Deltaproteobacteria,2M8CT@213115|Desulfovibrionales 28221|Deltaproteobacteria S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_352663_4 1385658.U5KPZ6_9VIRU 2.01e-204 586.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_109426_2 1449342.JQMR01000001_gene916 0.000819 44.3 COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,4HCA0@91061|Bacilli,27G2Z@186828|Carnobacteriaceae 91061|Bacilli L Calcineurin-like phosphoesterase superfamily domain yhaO - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,Metallophos_2 k59_15082_1 521098.Aaci_1499 9.53e-144 424.0 COG1403@1|root,COG1403@2|Bacteria,1TPT3@1239|Firmicutes,4HFAW@91061|Bacilli 91061|Bacilli V HNH nucleases - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_230632_1 247490.KSU1_C1324 1.98e-28 123.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_271238_1 78898.MVEG_00938T0 7.18e-17 82.8 2AAI5@1|root,2RYM5@2759|Eukaryota,39RH9@33154|Opisthokonta,3NYUV@4751|Fungi,1GT26@112252|Fungi incertae sedis 4751|Fungi S Sphaeroforma arctica JP610 - - - - - - - - - - - - Alginate_lyase k59_56083_1 1347393.HG726026_gene2622 1.37e-30 139.0 COG3941@1|root,COG3941@2|Bacteria,4NPQ5@976|Bacteroidetes,2FRTG@200643|Bacteroidia,4ASHV@815|Bacteroidaceae 976|Bacteroidetes S tape measure - - - - - - - - - - - - - k59_325694_1 1173762.S4TP25_9CAUD 1.35e-74 254.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_312631_2 268746.Q58MH9_BPPRM 2.93e-26 106.0 4QFNV@10239|Viruses,4QZT9@35237|dsDNA viruses no RNA stage,4QQJ1@28883|Caudovirales,4QHUR@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_190419_4 360910.BAV1477 4.2e-06 48.9 2EK5N@1|root,33DW2@2|Bacteria,1NHDG@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_84838_3 1123405.AUMM01000017_gene2712 8.79e-40 150.0 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,4HDMY@91061|Bacilli 91061|Bacilli L Phage terminase, large subunit yqaT - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_420967_1 1179155.CF67_14087 6.14e-51 165.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1XSPW@135623|Vibrionales 135623|Vibrionales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_420967_2 1183239.I1ZBF8_9VIRU 4.9e-39 145.0 4QATB@10239|Viruses,4QVUZ@35237|dsDNA viruses no RNA stage 10239|Viruses S Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - - k59_272608_1 1402875.U3TK13_9CAUD 3.74e-06 50.1 4QD7Q@10239|Viruses,4QWCG@35237|dsDNA viruses no RNA stage,4QPCM@28883|Caudovirales,4QNQT@10744|Podoviridae 10744|Podoviridae S Pfam:Phage_tail_APC - - - - - - - - - - - - - k59_3085_1 48698.ENSPFOP00000023559 4.6e-09 62.4 2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria,48HD7@7711|Chordata,49EDU@7742|Vertebrata 33208|Metazoa S DNA polymerase type B, organellar and viral - - - - - - - - - - - - DNA_pol_B_2,Rho_N k59_341575_1 696747.NIES39_A05260 9.65e-41 156.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G15Q@1117|Cyanobacteria,1H7TC@1150|Oscillatoriales 1117|Cyanobacteria L tpr repeat - - - - - - - - - - - - CHAT,TPR_10,TPR_8 k59_314942_1 713586.KB900536_gene889 3.29e-06 53.9 COG3210@1|root,COG3210@2|Bacteria,1NGFP@1224|Proteobacteria,1T54S@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_231833_1 1244083.CSUNSWCD_1235 6.01e-08 57.8 COG3340@1|root,COG3340@2|Bacteria,1RDKH@1224|Proteobacteria,42PV2@68525|delta/epsilon subdivisions,2YMXX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the peptidase S51 family - - 3.4.13.21 ko:K05995 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_178608_3 1692259.A0A0K1RL59_9CIRC 5.43e-13 71.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_327999_1 631454.N177_3007 1.55e-12 75.5 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM Phage - - - - - - - - - - - - Terminase_6C k59_57630_1 1283079.M1IPT5_9CAUD 6.42e-22 99.8 4QF7H@10239|Viruses,4R06M@35237|dsDNA viruses no RNA stage,4QQTS@28883|Caudovirales,4QNXE@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_72444_2 1244856.K4PW82_9CAUD 2.08e-211 608.0 4QD6D@10239|Viruses,4QZFH@35237|dsDNA viruses no RNA stage,4QUDK@28883|Caudovirales,4QP43@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_300263_2 1219035.NT2_13_00580 1.74e-48 177.0 2FC31@1|root,3446Z@2|Bacteria,1P2BX@1224|Proteobacteria,2UVC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_421069_1 573413.Spirs_2518 8.8e-53 179.0 COG3723@1|root,COG3723@2|Bacteria,2JADR@203691|Spirochaetes 203691|Spirochaetes L PFAM DNA single-strand annealing protein RecT-like - - - - - - - - - - - - RecT k59_286534_1 1096546.WYO_0171 4.69e-95 303.0 COG0553@1|root,COG0553@2|Bacteria,1PXS8@1224|Proteobacteria,2UAZ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria KL COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_328208_1 1327981.S0A2J0_9CAUD 3.19e-39 160.0 4QB2X@10239|Viruses,4QXYM@35237|dsDNA viruses no RNA stage,4QRYM@28883|Caudovirales,4QMB2@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_328208_2 1537917.JU82_08880 3.54e-07 58.5 COG5280@1|root,COG5280@2|Bacteria,1R240@1224|Proteobacteria 1224|Proteobacteria D Phage tail tape measure protein TP901 - - - - - - - - - - - - - k59_142095_1 1380387.JADM01000007_gene709 3.83e-48 160.0 COG4333@1|root,COG4333@2|Bacteria,1N19M@1224|Proteobacteria,1SAS8@1236|Gammaproteobacteria,1XQS8@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - DUF1643 k59_395965_2 113395.AXAI01000008_gene735 1.96e-16 79.0 COG1403@1|root,COG1403@2|Bacteria,1N0FM@1224|Proteobacteria,2TWQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ERF superfamily - - - - - - - - - - - - ERF k59_317573_1 1121285.AUFK01000002_gene40 1.12e-05 49.7 29D2S@1|root,3000U@2|Bacteria,4PGQF@976|Bacteroidetes,1IM4Y@117743|Flavobacteriia,3ZSNA@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_357356_2 1415780.JPOG01000001_gene1752 2.76e-08 59.7 2C5KH@1|root,333J0@2|Bacteria,1NBW7@1224|Proteobacteria,1STP2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_369435_1 1045009.AFXQ01000021_gene7 2.87e-18 89.4 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,1W7W1@1268|Micrococcaceae 201174|Actinobacteria L Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_369435_2 1444309.JAQG01000003_gene4458 2.3e-09 59.7 COG1989@1|root,COG1989@2|Bacteria,1VDGR@1239|Firmicutes,4HR4H@91061|Bacilli,26YNB@186822|Paenibacillaceae 91061|Bacilli NOU Type IV leader peptidase family - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - Peptidase_A24 k59_410572_1 1609634.A0A0C5AK24_9VIRU 6.74e-10 58.5 4QCC5@10239|Viruses,4QUKW@29258|ssDNA viruses,4QP4C@10841|Microviridae 10841|Microviridae S viral process - - - - - - - - - - - - - k59_329670_1 1197951.I6RT34_9CAUD 1.52e-146 429.0 4QGAG@10239|Viruses,4R0KB@35237|dsDNA viruses no RNA stage,4QUA4@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_329670_2 979533.F1D0V0_9CAUD 8.72e-69 229.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_33119_1 1177928.TH2_05253 5.44e-45 166.0 COG1511@1|root,COG3941@1|root,COG1511@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - DUF4175,TMP_2,Tape_meas_lam_C k59_5169_1 388051.AUFE01000035_gene4020 5.91e-86 276.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_142481_1 688245.CtCNB1_2647 9e-05 49.7 2AIAK@1|root,318RG@2|Bacteria,1Q0U0@1224|Proteobacteria,2W5QF@28216|Betaproteobacteria,4AIV3@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_167260_2 1692252.A0A0K1RL35_9CIRC 1.15e-104 314.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_193952_1 935948.KE386495_gene1689 8.38e-15 79.7 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42FJ3@68295|Thermoanaerobacterales 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_87376_1 158189.SpiBuddy_1226 0.000365 49.3 COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes 203691|Spirochaetes L DNA or RNA helicase of superfamily II - - 3.6.4.12 ko:K10843 ko03022,ko03420,map03022,map03420 M00290 - - ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - ERCC3_RAD25_C,Helicase_C_3,ResIII k59_410582_2 269482.Bcep1808_1155 6.95e-31 119.0 2DM17@1|root,319VU@2|Bacteria,1R6RI@1224|Proteobacteria,2WG8E@28216|Betaproteobacteria,1KIBI@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM GIY-YIG catalytic domain - - - - - - - - - - - - - k59_396189_1 1437608.BBIA_1877 7.56e-05 45.8 COG3740@1|root,COG3740@2|Bacteria,2IC7D@201174|Actinobacteria,4D0WJ@85004|Bifidobacteriales 201174|Actinobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78,Phage_capsid k59_396189_2 1470591.BW41_00283 6.65e-33 127.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,2K2QM@204457|Sphingomonadales 204457|Sphingomonadales S Phage portal protein - - - - - - - - - - - - Phage_portal k59_156074_1 742740.HMPREF9474_02265 1.59e-39 139.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,222RY@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_346482_1 926549.KI421517_gene1783 2.52e-16 80.9 COG0399@1|root,COG0399@2|Bacteria,4NFAI@976|Bacteroidetes,47JTR@768503|Cytophagia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family pglE - - - - - - - - - - - DegT_DnrJ_EryC1 k59_195779_1 411476.BACOVA_03899 9.01e-29 115.0 28KSZ@1|root,2ZAA8@2|Bacteria,4NHC3@976|Bacteroidetes,2FVKP@200643|Bacteroidia,4ASWA@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_195779_2 118166.JH976537_gene199 9.61e-07 57.0 COG2256@1|root,COG2256@2|Bacteria,1G36R@1117|Cyanobacteria,1H9UW@1150|Oscillatoriales 1117|Cyanobacteria L ATPase family associated with various cellular activities (AAA) mgs1 - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_195779_4 1049564.TevJSym_aa01350 1.89e-20 94.0 COG0224@1|root,COG0224@2|Bacteria,1QUME@1224|Proteobacteria,1S2EG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C WbqC-like protein family - - - - - - - - - - - - WbqC k59_195779_5 384765.SIAM614_24512 1.96e-08 59.7 COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,2TUTK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_346486_1 220341.16505358 2.84e-63 204.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria,3ZJ04@590|Salmonella 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_61437_1 1121904.ARBP01000041_gene4946 0.000289 46.2 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,47JK3@768503|Cytophagia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_145883_2 985762.SAGN_09672 0.000567 40.8 29IFN@1|root,30595@2|Bacteria,1TXWS@1239|Firmicutes,4I6ZE@91061|Bacilli,4GZKY@90964|Staphylococcaceae 91061|Bacilli S Belongs to the UPF0346 family - - - - - - - - - - - - YozE_SAM_like k59_320777_3 1266908.AQPB01000051_gene2474 2.65e-15 78.2 2EFFY@1|root,3398P@2|Bacteria,1NCVZ@1224|Proteobacteria,1SFQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Prophage minor tail protein Z (GPZ) - - - - - - - - - - - - Minor_tail_Z k59_346852_4 1476876.JOJO01000003_gene5438 0.000169 47.4 COG3598@1|root,COG3598@2|Bacteria,2H0QU@201174|Actinobacteria 201174|Actinobacteria L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - PriCT_1,Prim-Pol k59_331320_5 1096546.WYO_0193 2.68e-66 214.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria 1224|Proteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_169210_5 1234888.K0A2J2_9VIRU 5.68e-157 461.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_21525_1 1563661.A0A097PAP5_9CAUD 2.81e-10 66.2 4QBY0@10239|Viruses,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_307035_1 1273711.A0A096VKG4_9CAUD 3.67e-34 134.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_400119_1 203119.Cthe_0316 6.21e-14 78.6 COG2133@1|root,COG5183@1|root,COG2133@2|Bacteria,COG5183@2|Bacteria,1VRJN@1239|Firmicutes 1239|Firmicutes G PA14 - - - - - - - - - - - - PA14,RsgI_N k59_222728_4 1300143.CCAV010000006_gene4316 5.12e-69 234.0 COG1783@1|root,COG1783@2|Bacteria,4PGC2@976|Bacteroidetes,1IH7A@117743|Flavobacteriia,3ZT7A@59732|Chryseobacterium 976|Bacteroidetes S Phage terminase large subunit - - - - - - - - - - - - Terminase_3 k59_373140_1 713587.THITH_01625 9.99e-07 47.8 COG1551@1|root,COG1551@2|Bacteria 2|Bacteria T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563,ko:K13626 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko02035,ko03019 - - - CsrA k59_158829_3 272134.KB731324_gene4179 2.51e-09 58.5 2BJH7@1|root,32UCG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_23689_1 706587.Desti_1281 1.67e-32 123.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria,2MRS6@213462|Syntrophobacterales 28221|Deltaproteobacteria O 4Fe-4S single cluster domain pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_426715_7 742738.HMPREF9460_04053 7.4e-63 208.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,24B1A@186801|Clostridia,26A94@186813|unclassified Clostridiales 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_198413_1 1234888.K0A2J2_9VIRU 2.75e-59 202.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_198413_6 1234888.K0A2J2_9VIRU 1.19e-79 254.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_130586_1 1027371.GOALK_093_00570 1.81e-50 168.0 COG0863@1|root,COG0863@2|Bacteria,2HT6C@201174|Actinobacteria,4GG8Y@85026|Gordoniaceae 201174|Actinobacteria H DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_198416_1 1286632.P278_27950 1.47e-06 56.6 COG0747@1|root,COG2304@1|root,COG3210@1|root,COG3291@1|root,COG5492@1|root,COG0747@2|Bacteria,COG2304@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG5492@2|Bacteria,4NDZC@976|Bacteroidetes,1IJ8A@117743|Flavobacteriia 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - CHU_C,DUF11,Gal_Lectin,HYR,Laminin_G_3,PKD,SprB,TSP_3 k59_373153_1 326427.Cagg_2138 0.000126 43.9 COG1192@1|root,COG1192@2|Bacteria,2G62U@200795|Chloroflexi,374YK@32061|Chloroflexia 32061|Chloroflexia D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_385079_2 43989.cce_4468 2.08e-25 112.0 COG2189@1|root,COG2189@2|Bacteria,1G4UK@1117|Cyanobacteria,3KJ96@43988|Cyanothece 1117|Cyanobacteria L DNA methylase - - 2.1.1.72 ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_104763_1 696281.Desru_1096 7.05e-11 62.8 COG3405@1|root,COG3405@2|Bacteria,1VBUA@1239|Firmicutes,24WR1@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - k59_255156_1 1408304.JAHA01000008_gene1901 5.72e-21 95.9 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,4BY9U@830|Butyrivibrio 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_238953_1 1379725.S5SYG4_9CIRC 2.27e-31 122.0 4QASI@10239|Viruses,4QUM7@29258|ssDNA viruses 10239|Viruses L Geminivirus coat protein/nuclear export factor BR1 family - GO:0005575,GO:0018995,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0042025,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_225536_2 479433.Caci_4710 2.5e-05 48.1 COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - AAA_16,GerE k59_417800_1 1499967.BAYZ01000080_gene935 3.76e-05 53.5 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Beta_helix,Pectate_lyase_3 k59_134599_3 268746.Q58MX1_BPPRM 2.49e-13 84.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_255181_2 1226322.HMPREF1545_02801 6.13e-20 87.8 COG3108@1|root,COG3108@2|Bacteria 2|Bacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_282308_1 1123321.KB905822_gene3886 6.1e-22 99.0 29ZI2@1|root,30MI5@2|Bacteria,2IJSV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_188062_1 795359.TOPB45_0281 1.14e-06 52.0 COG0297@1|root,COG0297@2|Bacteria,2GH5G@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Starch synthase catalytic domain - - - - - - - - - - - - Glyco_transf_4,Glyco_transf_5,Glycos_transf_1 k59_188062_2 1288963.ADIS_1704 4.9e-18 84.7 COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,47P2J@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 57 family amyA - 3.2.1.1 ko:K07405 ko00500,ko01100,map00500,map01100 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH57 - Glyco_hydro_57 k59_107731_1 655815.ZPR_0754 3.47e-08 60.1 COG3693@1|root,COG3693@2|Bacteria,4NE5Z@976|Bacteroidetes,1HYN4@117743|Flavobacteriia 976|Bacteroidetes G Beta-xylanase xynA - 3.2.1.37,3.2.1.55,3.2.1.8 ko:K01181,ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_10 k59_429925_1 1676184.A0A186YBN5_9CIRC 1.45e-28 115.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_239265_1 1286632.P278_28060 1.97e-16 77.0 2DMPB@1|root,32SV8@2|Bacteria,4NSG4@976|Bacteroidetes,1I3FJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_282326_1 1070319.CAGGBEG34_900001 1.14e-52 176.0 COG4379@1|root,COG4379@2|Bacteria,1MX68@1224|Proteobacteria,2VRUV@28216|Betaproteobacteria,1K3HV@119060|Burkholderiaceae 28216|Betaproteobacteria S Tail protein - - - - - - - - - - - - - k59_255626_1 1170562.Cal6303_4644 1.22e-23 102.0 COG2340@1|root,COG2340@2|Bacteria,1G4UZ@1117|Cyanobacteria,1HU2C@1161|Nostocales 1117|Cyanobacteria S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP,HemolysinCabind,PPC k59_239278_1 273526.SMDB11_2590 4.15e-07 59.3 COG5301@1|root,COG5301@2|Bacteria,1MWNN@1224|Proteobacteria,1RR74@1236|Gammaproteobacteria,4016Z@613|Serratia 1236|Gammaproteobacteria S Phage tail-collar fibre protein H - - - - - - - - - - - Collar,DUF3751,Phage_fiber_2 k59_335592_3 436229.JOEH01000029_gene4865 6.54e-06 50.8 COG3409@1|root,COG3409@2|Bacteria,2GR1Q@201174|Actinobacteria,2NKK2@228398|Streptacidiphilus 201174|Actinobacteria M N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_188121_1 1537917.JU82_06570 3.79e-47 158.0 2CGG9@1|root,2ZVSJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_189771_3 1183438.GKIL_0880 6.78e-06 49.3 COG0270@1|root,COG0270@2|Bacteria,1G8NG@1117|Cyanobacteria 1117|Cyanobacteria L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_418973_1 1336208.JADY01000021_gene4026 3.58e-63 217.0 COG4643@1|root,COG5545@1|root,COG4643@2|Bacteria,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria L virulence-associated E family protein - - - - - - - - - - - - Prim-Pol,Toprim_3,VirE k59_108800_2 428125.CLOLEP_01400 5.42e-70 240.0 28JED@1|root,2Z98K@2|Bacteria,1TW1U@1239|Firmicutes,24CFD@186801|Clostridia,3WNW0@541000|Ruminococcaceae 186801|Clostridia K Bacterial regulatory proteins, luxR family - - - - - - - - - - - - GerE k59_405792_7 938278.CAJO01000051_gene782 9.13e-17 81.6 COG5492@1|root,COG5492@2|Bacteria,1V2Y7@1239|Firmicutes 1239|Firmicutes N domain, Protein - - - - - - - - - - - - - k59_257201_2 585425.KR52_03475 2.11e-50 170.0 29CPA@1|root,2ZZMJ@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_257201_4 395961.Cyan7425_3706 5.43e-51 175.0 COG0338@1|root,COG0338@2|Bacteria,1G2H8@1117|Cyanobacteria,3KHAX@43988|Cyanothece 1117|Cyanobacteria H D12 class N6 adenine-specific DNA methyltransferase dmnB - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_365253_1 1618258.A0A0C5I9K3_9CIRC 2.49e-20 97.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_41588_1 1477404.A0A023NHC3_9CAUD 9.34e-40 137.0 4QAR6@10239|Viruses,4QUTK@35237|dsDNA viruses no RNA stage,4QPS2@28883|Caudovirales,4QNRU@10744|Podoviridae 10744|Podoviridae S dUTPase - - - - - - - - - - - - - k59_203773_1 345201.VF067_IIV3 5.4e-48 171.0 4QHP1@10239|Viruses,4QV4H@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_176146_2 189753.AXAS01000014_gene5585 2.23e-06 51.6 COG3381@1|root,COG4197@1|root,COG3381@2|Bacteria,COG4197@2|Bacteria,1MWWM@1224|Proteobacteria,2TU06@28211|Alphaproteobacteria,3JTAZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Nitrate reductase delta subunit torD - - - - - - - - - - - Nitrate_red_del,YdaS_antitoxin k59_338399_1 1540097.A0A0A0YRN0_9CAUD 4.52e-68 230.0 4QF3C@10239|Viruses,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_311668_1 1477404.A0A023NHF3_9CAUD 1.65e-44 146.0 4QEB1@10239|Viruses,4QXE4@35237|dsDNA viruses no RNA stage,4QT2R@28883|Caudovirales,4QP3K@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_311668_2 490913.C4NTF7_9CAUD 4.7e-37 130.0 4QGM6@10239|Viruses,4QYNV@35237|dsDNA viruses no RNA stage,4QRH4@28883|Caudovirales,4QP0P@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_55494_1 1692244.A0A0K1RLR5_9CIRC 3.59e-74 234.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_150884_20 691965.D4P7I8_9CAUD 6.24e-38 135.0 4QGJH@10239|Viruses,4QZ35@35237|dsDNA viruses no RNA stage,4QRZS@28883|Caudovirales,4QMAA@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_150884_21 691965.D4P7I3_9CAUD 0.0 1566.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_150884_24 742740.HMPREF9474_02310 5.93e-55 187.0 2A0KC@1|root,2ZGJK@2|Bacteria,1V2JS@1239|Firmicutes,24H6R@186801|Clostridia,222B7@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_340319_3 1123057.P872_18430 3.05e-29 124.0 29YBT@1|root,30K65@2|Bacteria,4NY8W@976|Bacteroidetes,47SZM@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_42900_4 1096546.WYO_0203 2.23e-97 309.0 COG1783@1|root,COG1783@2|Bacteria,1RAGC@1224|Proteobacteria,2U6JF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S phage Terminase large subunit - - - - - - - - - - - - - k59_42900_9 470145.BACCOP_00235 8.98e-42 143.0 COG3023@1|root,COG3023@2|Bacteria,4P37K@976|Bacteroidetes,2FRZB@200643|Bacteroidia,4AQJD@815|Bacteroidaceae 976|Bacteroidetes V Psort location Cytoplasmic, score 8.96 - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_353663_3 63737.Npun_R4784 9.57e-09 62.8 COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,1G3AH@1117|Cyanobacteria,1HRDT@1161|Nostocales 1117|Cyanobacteria L DNA methylase - - 2.1.1.113,2.1.1.72 ko:K00590,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_353663_5 294631.Q5ZGB2_9CAUD 1.98e-75 233.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_420258_1 84531.JMTZ01000032_gene360 1.03e-14 82.8 COG1196@1|root,COG1293@1|root,COG5281@1|root,COG1196@2|Bacteria,COG1293@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1S3MM@1236|Gammaproteobacteria,1XC2I@135614|Xanthomonadales 135614|Xanthomonadales D tape measure protein - - - - - - - - - - - - - k59_353927_3 1379715.S5TMW6_9CIRC 1.85e-12 72.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_164189_2 359.CN09_09375 1.26e-30 122.0 COG0863@1|root,COG0863@2|Bacteria,1PCS4@1224|Proteobacteria,2VDM8@28211|Alphaproteobacteria,4BIRX@82115|Rhizobiaceae 28211|Alphaproteobacteria H DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_300872_1 742925.D4N3R4_9CIRC 3.49e-18 85.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_58388_1 195105.CN97_11605 2.65e-41 151.0 COG2518@1|root,COG2518@2|Bacteria,1QUS4@1224|Proteobacteria,2U2IM@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Domain of unknown function (DUF3560) - - - - - - - - - - - - - k59_31474_1 477184.KYC_17517 9.22e-11 62.4 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,2VWGT@28216|Betaproteobacteria,3T7S7@506|Alcaligenaceae 28216|Betaproteobacteria S D-alanyl-D-alanine carboxypeptidase - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_3844_2 742740.HMPREF9474_02274 5.5e-34 123.0 2DHA9@1|root,32U8X@2|Bacteria,1VD44@1239|Firmicutes,24NC3@186801|Clostridia,222SC@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_3844_3 1449065.JMLL01000001_gene4032 8.31e-14 78.2 2DPC3@1|root,331GE@2|Bacteria,1Q7WJ@1224|Proteobacteria,2UUNZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_3844_4 742733.HMPREF9469_05036 2.1e-46 154.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_3844_5 411460.RUMTOR_01353 9.66e-28 105.0 2CGGA@1|root,345NF@2|Bacteria,1VZU0@1239|Firmicutes,253ZW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_3844_6 1123258.AQXZ01000019_gene3183 1.28e-12 82.0 COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria 201174|Actinobacteria S fibronectin type III domain - - - - - - - - - - - - fn3 k59_3844_7 243233.MCA2930 3.38e-19 93.2 COG5301@1|root,COG5301@2|Bacteria,1NDIE@1224|Proteobacteria,1SFIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_232422_9 652103.Rpdx1_2986 3.41e-32 122.0 COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,2U0C2@28211|Alphaproteobacteria,3JWM5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide k59_421575_1 1384049.CD29_03560 2.12e-14 78.6 COG3935@1|root,COG3935@2|Bacteria,1TSHD@1239|Firmicutes,4I473@91061|Bacilli,3IYIA@400634|Lysinibacillus 91061|Bacilli L DnaD domain protein - - - - - - - - - - - - Phg_2220_C k59_207328_2 640081.Dsui_0729 3.29e-07 58.5 COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria 28216|Betaproteobacteria MU TIGRFAM outer membrane autotransporter barrel domain protein - - - - - - - - - - - - Autotransporter,He_PIG,TIG k59_207328_5 264462.Bd3267 1.65e-09 68.9 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1NED3@1224|Proteobacteria,42WDX@68525|delta/epsilon subdivisions,2MTVC@213481|Bdellovibrionales,2WRDH@28221|Deltaproteobacteria 213481|Bdellovibrionales U cell wall surface anchor family protein - - - - - - - - - - - - Peptidase_S74 k59_300964_1 1220601.L7TML5_9CAUD 7.58e-24 96.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - GO:0005575,GO:0018995,GO:0019012,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044423,GO:0046729 - - - - - - - - - - - k59_316193_1 1045858.Bint_1533 2.28e-120 370.0 COG5511@1|root,COG5511@2|Bacteria 2|Bacteria F Phage portal protein, lambda family JD73_18735 - - - - - - - - - - - Phage_portal_2 k59_85967_1 1007105.PT7_P071 1.52e-12 71.6 28N2X@1|root,2ZB8P@2|Bacteria,1R4KJ@1224|Proteobacteria,2WDTP@28216|Betaproteobacteria,3T8AJ@506|Alcaligenaceae 28216|Betaproteobacteria S sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7 - - - - - - - - - - - - - k59_192689_2 1423321.AS29_06740 5.45e-47 168.0 COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,4IQQV@91061|Bacilli,1ZRMU@1386|Bacillus 91061|Bacilli M GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Polysacc_synt_2 k59_192689_3 935837.JAEK01000070_gene3334 1.91e-49 171.0 COG1091@1|root,COG1091@2|Bacteria,1TREY@1239|Firmicutes,4HF9V@91061|Bacilli,1ZQAK@1386|Bacillus 91061|Bacilli M RmlD substrate binding domain - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_140433_2 1231190.NA8A_19588 2.66e-10 65.1 COG0863@1|root,COG0863@2|Bacteria,1R7KV@1224|Proteobacteria,2U3KV@28211|Alphaproteobacteria,43Q9K@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L DNA methylase - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_355889_1 1380394.JADL01000003_gene4945 4.36e-11 71.2 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,2JPYW@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the N(4) N(6)-methyltransferase family ccrM - 2.1.1.72 ko:K13581 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko02048 - - - N6_N4_Mtase k59_19782_12 1556290.A0A0A0RQP8_9CAUD 1.85e-35 137.0 4QBG4@10239|Viruses,4QRSK@28883|Caudovirales,4QKVU@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_275149_10 5762.XP_002670908.1 5.49e-30 120.0 2CXIM@1|root,2RXVF@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_34026_1 1270196.JCKI01000005_gene2928 9.73e-08 55.5 COG3298@1|root,COG3298@2|Bacteria,4NECH@976|Bacteroidetes,1IR1A@117747|Sphingobacteriia 976|Bacteroidetes L 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_249222_1 1265507.KB899637_gene625 4.53e-11 68.6 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_101242_1 388051.AUFE01000035_gene4020 2.5e-81 255.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_20041_1 402612.FP0341 2.65e-59 207.0 COG0587@1|root,COG0587@2|Bacteria,4NFA0@976|Bacteroidetes,1HXPM@117743|Flavobacteriia,2NUVG@237|Flavobacterium 976|Bacteroidetes L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_34027_1 1168547.L7P648_9CIRC 1.66e-30 126.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_289031_1 1283076.M1ICV0_9CAUD 2.17e-24 102.0 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QI9Y@10662|Myoviridae 10662|Myoviridae S ATPase family associated with various cellular activities (AAA) - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_194770_2 1423814.HMPREF0549_1779 1.13e-27 110.0 2DR9Y@1|root,33AUY@2|Bacteria,1VEP1@1239|Firmicutes,4HP3X@91061|Bacilli,3F7WJ@33958|Lactobacillaceae 91061|Bacilli L NUMOD4 motif - - - - - - - - - - - - HNH_3,NUMOD4 k59_345239_1 404380.Gbem_3867 7.68e-10 65.1 COG4870@1|root,COG4870@2|Bacteria,1MV6S@1224|Proteobacteria,42P5Q@68525|delta/epsilon subdivisions,2WKD3@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Papain family cysteine protease - - - - - - - - - - - - Peptidase_C1 k59_358904_1 1300143.CCAV010000006_gene4312 3.44e-37 140.0 COG4653@1|root,COG4653@2|Bacteria,4P9ZK@976|Bacteroidetes,1IM07@117743|Flavobacteriia,3ZTHB@59732|Chryseobacterium 976|Bacteroidetes S Phage capsid family - - - - - - - - - - - - - k59_210470_4 1158318.ATXC01000001_gene1215 6.21e-08 56.2 COG1351@1|root,COG1351@2|Bacteria,2G5G0@200783|Aquificae 200783|Aquificae F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_34029_2 1618248.A0A0C5IB82_9CIRC 3.48e-91 280.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_194778_1 592028.GCWU000321_01359 4.82e-91 283.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4H2V4@909932|Negativicutes 909932|Negativicutes KL DEAD-like helicases superfamily - - - - - - - - - - - - N6_N4_Mtase k59_46711_1 1131266.ARWQ01000006_gene286 2.01e-10 67.8 COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota 651137|Thaumarchaeota L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis dbh - 2.7.7.7 ko:K04479 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_20053_4 1429767.W6B178_9CAUD 2.91e-13 70.1 4QCUB@10239|Viruses,4QYNV@35237|dsDNA viruses no RNA stage,4QRVM@28883|Caudovirales,4QNUK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_6108_1 864069.MicloDRAFT_00032110 4.48e-05 46.6 2DSGM@1|root,33G20@2|Bacteria,1NM38@1224|Proteobacteria,2UW9B@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_236206_1 10742.Q9MCV7_BPHK0 8.87e-17 83.2 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_147382_1 246195.DNO_0769 1.24e-19 89.4 2CS3D@1|root,32SQ7@2|Bacteria,1N5BY@1224|Proteobacteria,1S9EX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_265739_1 1788454.A0A190WHE4_9CIRC 5.94e-31 121.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_413567_1 105154.Q9MBU2_9VIRU 6.76e-13 67.4 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_413567_2 145579.H_BPPHM 1.19e-12 71.6 4QCA6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_372151_1 1120971.AUCA01000053_gene371 5.74e-102 304.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_147397_1 381666.H16_B1522 8.51e-10 60.1 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,2VPEM@28216|Betaproteobacteria,1K1IK@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,dCache_1 k59_251348_2 1380394.JADL01000008_gene3764 3.19e-27 113.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_213116_1 1403948.Q618_VCMC00003G0099 3.7e-30 116.0 COG1388@1|root,COG1388@2|Bacteria,2I3RK@201174|Actinobacteria 201174|Actinobacteria M LysM domain - - - - - - - - - - - - - k59_157777_2 391612.CY0110_04663 1.02e-05 50.8 COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,3KFZ7@43988|Cyanothece 2|Bacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986,ko:K07451 - - - - ko00000,ko01000,ko02048 - - - GIIM,HNH,RVT_1,RVT_N k59_277656_1 1220535.IMCC14465_13520 1.67e-77 261.0 COG5545@1|root,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria L virulence-associated E family protein - - - - - - - - - - - - Prim-Pol,Toprim_3,VirE k59_157782_2 1538804.A0A088FAL2_9CAUD 3e-16 73.9 4QBB2@10239|Viruses,4QRAZ@28883|Caudovirales,4QKR3@10699|Siphoviridae 10699|Siphoviridae S 6-pyruvoyl tetrahydropterin synthase - - - - - - - - - - - - - k59_221964_2 1224163.B841_01995 5.92e-11 68.6 2AV5J@1|root,31KVW@2|Bacteria,2HPM8@201174|Actinobacteria,22PZ7@1653|Corynebacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_215489_1 1121447.JONL01000012_gene3405 2.44e-24 107.0 COG0503@1|root,COG2518@1|root,COG0503@2|Bacteria,COG2518@2|Bacteria 2|Bacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins apt - 2.1.1.163,2.1.1.201,2.1.1.77,2.4.2.7 ko:K00573,ko:K00759,ko:K03183,ko:K07003 ko00130,ko00230,ko01100,ko01110,map00130,map00230,map01100,map01110 M00116,M00117 R00190,R01229,R04378,R04990,R04993,R06859,R08774,R09736 RC00003,RC00063,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000,ko04147 - - - DUF3560,Methyltransf_21,Pribosyltran k59_117363_1 1304875.JAFZ01000001_gene1395 3.64e-27 114.0 COG0305@1|root,COG0305@2|Bacteria,3TAGD@508458|Synergistetes 508458|Synergistetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_364094_1 43989.cce_5301 1.46e-40 140.0 2EPJJ@1|root,33H66@2|Bacteria,1GDPT@1117|Cyanobacteria 1117|Cyanobacteria S Firmicute plasmid replication protein (RepL) - - - - - - - - - - - - - k59_279316_1 159749.K0SEK7 4.95e-17 80.1 COG2036@1|root,KOG3467@2759|Eukaryota,2XG8Q@2836|Bacillariophyta 2759|Eukaryota B Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044424,GO:0044464 - ko:K11254 ko05034,ko05203,ko05322,map05034,map05203,map05322 - - - ko00000,ko00001,ko03036 - - - CENP-T_C k59_185374_2 1132026.I6NMA8_9CAUD 4.72e-16 73.9 4QE7X@10239|Viruses,4QVF0@35237|dsDNA viruses no RNA stage,4QPUM@28883|Caudovirales,4QMAZ@10699|Siphoviridae 10699|Siphoviridae S Cytidine and deoxycytidylate deaminase zinc-binding region - - - - - - - - - - - - - k59_400790_1 1500259.JQLD01000001_gene3764 6.12e-53 183.0 COG5362@1|root,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2U236@28211|Alphaproteobacteria 28211|Alphaproteobacteria L TIGRFAM Phage - - - - - - - - - - - - Terminase_6 k59_294399_1 665956.HMPREF1032_00650 3.18e-70 228.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia,3WN6X@541000|Ruminococcaceae 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_10287_2 675635.Psed_1226 3.17e-07 55.5 2A0KW@1|root,30NR5@2|Bacteria,2I9N7@201174|Actinobacteria,4E2FK@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_131692_2 740709.A10D4_12794 1.51e-11 73.2 COG3206@1|root,COG3206@2|Bacteria,1QA2F@1224|Proteobacteria,1S04M@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - YqaJ k59_131692_3 860228.Ccan_00160 1.06e-33 125.0 COG3298@1|root,COG3298@2|Bacteria,4NECH@976|Bacteroidetes,1HY85@117743|Flavobacteriia,1EQFC@1016|Capnocytophaga 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_131692_11 1327941.T1SBI7_9CAUD 1e-36 134.0 4QEW7@10239|Viruses,4QYXF@35237|dsDNA viruses no RNA stage,4QTWH@28883|Caudovirales,4QNW2@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_430569_2 1692252.A0A0K1RL35_9CIRC 1.25e-43 158.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_404206_1 439235.Dalk_4598 1.04e-34 132.0 28KIJ@1|root,2ZA3S@2|Bacteria,1R4PD@1224|Proteobacteria,42ZCD@68525|delta/epsilon subdivisions,2WTNZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_377178_2 406817.XNC1_3413 1.17e-32 129.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2 k59_430576_6 1692246.A0A0K1RL26_9CIRC 4.45e-16 81.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_430578_1 1618248.A0A0C5IB82_9CIRC 1.93e-11 63.5 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_430578_2 1788454.A0A190WHE4_9CIRC 3.52e-52 177.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_404248_2 1112217.PPL19_12528 5.04e-28 106.0 COG4696@1|root,COG4696@2|Bacteria,1N92T@1224|Proteobacteria,1SP95@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_388098_3 113395.AXAI01000008_gene880 5.22e-10 58.2 29B7J@1|root,2ZY5Y@2|Bacteria,1NND5@1224|Proteobacteria,2UKRN@28211|Alphaproteobacteria,3K24Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_388960_3 870187.Thini_0411 8.64e-19 94.4 2EP1Y@1|root,33GNT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_388968_1 104355.XP_007862338.1 3.09e-15 75.5 COG1678@1|root,KOG1567@2759|Eukaryota,38B80@33154|Opisthokonta,3NW0V@4751|Fungi,3UYFI@5204|Basidiomycota,226GU@155619|Agaricomycetes,3H090@355688|Agaricomycetes incertae sedis 4751|Fungi F ribonucleotide reductase - - 1.17.4.1 ko:K10808 ko00230,ko00240,ko00480,ko00983,ko01100,ko04115,map00230,map00240,map00480,map00983,map01100,map04115 M00053 R02017,R02019,R02024,R08363,R08364,R11893 RC00613,RC01003 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_297902_2 991905.SL003B_1168 1.19e-27 105.0 COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,2UBSF@28211|Alphaproteobacteria,4BSR8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Predicted membrane protein (DUF2177) - - - - - - - - - - - - DUF2177 k59_109051_1 1498011.A0A096XUS7_9CAUD 7.84e-43 158.0 4QAUF@10239|Viruses,4QQIV@28883|Caudovirales,4QNZ6@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_325116_1 1123368.AUIS01000020_gene1078 2.41e-10 61.2 28XPA@1|root,2ZJK5@2|Bacteria,1P9T2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_55701_1 1219035.NT2_13_00580 7.52e-59 204.0 2FC31@1|root,3446Z@2|Bacteria,1P2BX@1224|Proteobacteria,2UVC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_68927_2 399739.Pmen_0185 1.25e-13 73.2 COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1YD3S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - DUF4124,Peptidase_M23 k59_109058_1 439809.A5YK40_9CAUD 3.89e-16 82.8 4QM02@10699|Siphoviridae 10699|Siphoviridae S C-5 cytosine-specific DNA methylase - - - - - - - - - - - - - k59_311964_8 1120936.KB907208_gene1066 2e-143 425.0 28MN1@1|root,2ZAXN@2|Bacteria,2H2TF@201174|Actinobacteria 201174|Actinobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_82347_1 1313172.YM304_09440 3.1e-22 105.0 COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria 201174|Actinobacteria L type III restriction enzyme, res subunit sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - ResIII k59_312287_1 1131812.JQMS01000001_gene1141 7.65e-25 108.0 COG3378@1|root,COG3378@2|Bacteria,4PP9A@976|Bacteroidetes,1IKGT@117743|Flavobacteriia,2NYJZ@237|Flavobacterium 976|Bacteroidetes S Phage plasmid primase P4 family - - - - - - - - - - - - VirE_N k59_82583_1 1298867.AUES01000073_gene3749 2.04e-40 139.0 2BYV0@1|root,33V2M@2|Bacteria,1N6IX@1224|Proteobacteria,2UE7P@28211|Alphaproteobacteria,3K4T8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - PDDEXK_1 k59_69256_1 1385658.U5KPZ6_9VIRU 1.72e-105 327.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_312296_1 1122138.AQUZ01000004_gene995 1.58e-07 60.8 COG5412@1|root,COG5412@2|Bacteria 2|Bacteria N phage tail tape measure protein - - - - - - - - - - - - - k59_1301_2 928210.CALU01000006_gene631 1.19e-10 69.3 COG3756@1|root,COG3756@2|Bacteria,1NQA5@1224|Proteobacteria,2UXA9@28211|Alphaproteobacteria,48UQM@772|Bartonellaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_55906_3 1417296.U879_13355 3.23e-27 99.8 2E424@1|root,32YYN@2|Bacteria,1NE0X@1224|Proteobacteria,2UH42@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_110603_4 1692255.A0A0K1RL52_9CIRC 5.63e-15 79.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_30082_1 1196835.A458_06950 3.48e-50 188.0 COG1511@1|root,COG5281@1|root,COG1511@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1TAY6@1236|Gammaproteobacteria,1Z3JC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria D tape measure protein - - - - - - - - - - - - - k59_97302_2 536019.Mesop_6478 4.41e-14 69.7 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,43KDZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_71347_1 349741.Amuc_0731 1.12e-68 221.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K16703 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_327343_1 1121864.OMO_01316 5.84e-44 179.0 COG5283@1|root,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HEHJ@91061|Bacilli 91061|Bacilli D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_84500_1 1458357.BG58_11025 2.37e-14 74.3 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,1KAW7@119060|Burkholderiaceae 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_245953_1 1168478.I6S2C5_9CAUD 9.69e-59 189.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QKNC@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_314544_1 1177928.TH2_05208 3.6e-27 123.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,2JV2T@204441|Rhodospirillales 204441|Rhodospirillales S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Lambda_tail_I,Phage-tail_3 k59_341248_1 907348.TresaDRAFT_0092 4.78e-21 95.5 COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes 203691|Spirochaetes L Uracil-DNA glycosylase, family 4 ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_30307_1 294631.Q5ZGF9_9CAUD 1.09e-26 111.0 4QC5Z@10239|Viruses,4QUNP@35237|dsDNA viruses no RNA stage,4QPGX@28883|Caudovirales,4QKMB@10699|Siphoviridae 10699|Siphoviridae S Phage Mu protein F like protein - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_178285_1 66692.ABC1368 2.06e-35 149.0 COG3378@1|root,COG4983@1|root,COG3378@2|Bacteria,COG4983@2|Bacteria,1TQP9@1239|Firmicutes,4HBTB@91061|Bacilli,1ZEU3@1386|Bacillus 91061|Bacilli S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,PriCT_1,Prim-Pol k59_178285_3 1232437.KL662018_gene575 3.72e-09 62.8 COG2887@1|root,COG2887@2|Bacteria,1RAZ0@1224|Proteobacteria,42R3A@68525|delta/epsilon subdivisions,2WN5C@28221|Deltaproteobacteria,2MK0M@213118|Desulfobacterales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - ko:K07465 - - - - ko00000 - - - PDDEXK_1 k59_138755_1 679197.HMPREF9336_00431 7.05e-06 56.6 COG3378@1|root,COG3378@2|Bacteria,2GQQM@201174|Actinobacteria 201174|Actinobacteria S Phage plasmid primase P4 family - - - - - - - - - - - - D5_N k59_138755_3 417280.A1YZY9_9CAUD 1.93e-54 185.0 4QCW5@10239|Viruses,4QWI1@35237|dsDNA viruses no RNA stage,4QQVP@28883|Caudovirales,4QHUS@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_327724_1 717785.HYPMC_1228 5.71e-25 97.1 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_393990_1 416870.llmg_1922 2.79e-14 79.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,4HATQ@91061|Bacilli,1YB8Z@1357|Lactococcus 91061|Bacilli L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_208382_1 1125725.HMPREF1325_1303 2.54e-36 137.0 COG3723@1|root,COG3723@2|Bacteria,2JADR@203691|Spirochaetes 203691|Spirochaetes L PFAM DNA single-strand annealing protein RecT-like - - - - - - - - - - - - RecT k59_316990_1 679926.Mpet_0741 1.08e-08 64.7 COG1520@1|root,COG3291@1|root,arCOG02416@1|root,arCOG07813@1|root,arCOG02416@2157|Archaea,arCOG02482@2157|Archaea,arCOG02508@2157|Archaea,arCOG07813@2157|Archaea,2XUI1@28890|Euryarchaeota 28890|Euryarchaeota T COG1520 FOG WD40-like repeat - - - - - - - - - - - - PKD k59_99498_1 1209072.ALBT01000031_gene1886 1.12e-22 108.0 COG2372@1|root,COG3209@1|root,COG2372@2|Bacteria,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - ko:K07156 - - - - ko00000,ko02000 9.B.62.2 - - Big_5,DUF4082,SLH k59_368884_2 1123366.TH3_20803 1.35e-07 58.2 COG4227@1|root,COG4643@1|root,COG4227@2|Bacteria,COG4643@2|Bacteria,1MU8I@1224|Proteobacteria,2TRIT@28211|Alphaproteobacteria,2JRBB@204441|Rhodospirillales 204441|Rhodospirillales L COG4227 Antirestriction protein - - - - - - - - - - - - DUF1738,Toprim_3 k59_317002_1 1327036.R4JQQ9_9CAUD 6.33e-30 112.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_422166_2 1168281.I3PUZ8_9CAUD 1.15e-08 55.5 4QD4R@10239|Viruses,4QUPD@35237|dsDNA viruses no RNA stage,4QTAJ@28883|Caudovirales,4QNC6@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF3268) - - - - - - - - - - - - - k59_422166_4 1206730.BAGA01000127_gene4332 2.4e-12 77.8 COG0739@1|root,COG0739@2|Bacteria,2GM7Q@201174|Actinobacteria,4FVHR@85025|Nocardiaceae 201174|Actinobacteria M Peptidase family M23 mepA - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_356698_2 279280.Q6J1R9_9CAUD 2.53e-146 422.0 4QH0X@10239|Viruses,4QXIJ@35237|dsDNA viruses no RNA stage,4QSY6@28883|Caudovirales,4QNTU@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_74388_1 994601.G9BWF6_9CAUD 1.16e-17 88.2 4QH67@10239|Viruses,4QXEE@35237|dsDNA viruses no RNA stage,4QTBT@28883|Caudovirales,4QNP4@10744|Podoviridae 10744|Podoviridae S Terminase-like family - - - - - - - - - - - - - k59_422337_1 1121946.AUAX01000015_gene6092 3.04e-28 115.0 COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4DAV6@85008|Micromonosporales 201174|Actinobacteria S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_21312_1 1403819.BATR01000046_gene1343 2.21e-32 132.0 COG3941@1|root,COG3941@2|Bacteria,46Z3Y@74201|Verrucomicrobia,2IWBM@203494|Verrucomicrobiae 203494|Verrucomicrobiae S tape measure - - - - - - - - - - - - - k59_61563_3 691965.D4P7I3_9CAUD 9.38e-33 129.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_21318_1 1144313.PMI10_00661 2.46e-55 195.0 2DNIX@1|root,32XR6@2|Bacteria,4NU21@976|Bacteroidetes,1I3XV@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_102391_1 1224164.B843_03450 3.47e-38 157.0 COG3941@1|root,COG5412@1|root,COG3941@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,22N4W@1653|Corynebacteriaceae 201174|Actinobacteria M Tail protein - - - - - - - - - - - - - k59_128471_2 426355.Mrad2831_5343 1.75e-11 63.2 28JWE@1|root,2Z9M6@2|Bacteria,1R76R@1224|Proteobacteria,2U0BP@28211|Alphaproteobacteria,1JU2G@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_146101_1 694427.Palpr_1970 4.99e-15 80.5 COG4675@1|root,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein - - - - - - - - - - - - Collar k59_48206_1 667121.ET1_08_00850 0.000501 42.0 COG4197@1|root,COG4197@2|Bacteria,1NC9Y@1224|Proteobacteria,1SFXS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA-binding transcriptional regulator Cro - - - - - - - - - - - - P22_Cro k59_61849_1 880073.Calab_1470 4.96e-48 163.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_61849_4 1414766.A0A0A0P0H0_9VIRU 3.92e-14 68.9 4QH92@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_156553_2 1676184.A0A186YBN5_9CIRC 5.76e-15 75.5 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_169267_1 548479.HMPREF0573_11399 7.42e-27 117.0 COG5412@1|root,COG5412@2|Bacteria,2IH91@201174|Actinobacteria,4D7WS@85005|Actinomycetales 201174|Actinobacteria S phage tail tape measure protein - - - - - - - - - - - - - k59_331403_1 445970.ALIPUT_01194 5.31e-08 53.5 2E8S0@1|root,3332X@2|Bacteria,4NWIA@976|Bacteroidetes,2FUQI@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_331403_2 1123058.KB894219_gene152 1.14e-74 241.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,4NN30@976|Bacteroidetes 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Terminase_6,Terminase_6C k59_264944_1 10689.H9C0B5_BPCPT 1.71e-41 142.0 4QEGD@10239|Viruses,4QVU1@35237|dsDNA viruses no RNA stage,4QPN9@28883|Caudovirales,4QJCM@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_264944_2 1264700.L0MYI2_9CAUD 2.68e-14 74.7 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_128489_1 406552.NJ7G_0032 1.19e-41 157.0 COG3497@1|root,arCOG11414@2157|Archaea,2XVT0@28890|Euryarchaeota,23URW@183963|Halobacteria 183963|Halobacteria S COG3497 Phage tail sheath protein FI - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_128489_2 929556.Solca_2157 5.72e-07 54.7 2DB76@1|root,2Z7JZ@2|Bacteria,4NQDC@976|Bacteroidetes,1ISNB@117747|Sphingobacteriia 976|Bacteroidetes S PFAM T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_115160_2 1327981.S0A2G1_9CAUD 7.93e-149 440.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_398313_1 1469607.KK073768_gene4912 1.88e-12 71.6 2DECZ@1|root,2ZMGD@2|Bacteria,1GGGC@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_264946_1 563192.HMPREF0179_02963 7.12e-09 65.9 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - ko:K03529 - - - - ko00000,ko03036 - - - PhageMin_Tail,Tape_meas_lam_C k59_216448_1 393283.XP_007841686.1 8.43e-31 122.0 COG0462@1|root,KOG1448@2759|Eukaryota,38CQV@33154|Opisthokonta,3NU9Y@4751|Fungi,3QJJS@4890|Ascomycota,212AI@147550|Sordariomycetes 4751|Fungi EF Ribose-phosphate pyrophosphokinase PRS4 GO:0002189,GO:0003674,GO:0003824,GO:0004749,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008361,GO:0009058,GO:0009987,GO:0016043,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0031505,GO:0032535,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045229,GO:0046390,GO:0046391,GO:0061695,GO:0065007,GO:0065008,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0090066,GO:0090407,GO:1901135,GO:1901137,GO:1901576,GO:1902494,GO:1990234 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_14056_1 1618248.A0A0C5IB82_9CIRC 3.55e-96 293.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_324382_1 1121930.AQXG01000014_gene350 1.07e-08 61.6 COG1404@1|root,COG2356@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2356@2|Bacteria,COG3291@2|Bacteria,4PI1X@976|Bacteroidetes,1IXYZ@117747|Sphingobacteriia 976|Bacteroidetes L Endonuclease I - - - - - - - - - - - - Endonuclease_1 k59_149054_2 585502.HMPREF0645_2609 4.94e-228 663.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,2FRI5@200643|Bacteroidia 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_189468_1 536233.CLO_1816 1.53e-100 300.0 COG0863@1|root,COG0863@2|Bacteria,1V0ZF@1239|Firmicutes,24CQV@186801|Clostridia,36J76@31979|Clostridiaceae 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_68115_1 1122212.AULO01000011_gene514 9.75e-22 97.1 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1XK3A@135619|Oceanospirillales 135619|Oceanospirillales C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_55070_3 1120792.JAFV01000001_gene592 4.01e-14 73.6 COG3740@1|root,COG3740@2|Bacteria 2|Bacteria OU Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_270393_3 1609634.A0A0C5AFV4_9VIRU 6.84e-11 62.4 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_311200_2 1502851.FG93_01932 1.15e-20 98.2 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_256905_1 1379717.S5SY19_9CIRC 1.71e-30 123.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_203468_1 1492738.FEM21_01840 3.75e-28 118.0 COG4974@1|root,COG4974@2|Bacteria,4NX3Q@976|Bacteroidetes,1HXCN@117743|Flavobacteriia,2NTGV@237|Flavobacterium 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase k59_283839_1 355246.Q333E4_9CAUD 1.27e-18 85.9 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_162528_4 388051.AUFE01000035_gene4020 3.31e-126 379.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_27811_1 1122201.AUAZ01000010_gene2527 4.11e-13 75.9 2DZHM@1|root,32VAY@2|Bacteria,1N0DC@1224|Proteobacteria,1SP9I@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_149080_1 990073.ATHU01000001_gene839 1.32e-29 115.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2YNDI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_243685_1 639283.Snov_1953 4.81e-13 77.8 COG5281@1|root,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2TW9T@28211|Alphaproteobacteria,3F0FI@335928|Xanthobacteraceae 28211|Alphaproteobacteria S tape measure protein - - - - - - - - - - - - - k59_27980_1 1481186.A0A075DXE8_9CAUD 3.88e-09 62.8 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_108691_1 10704.B4UTY8_BP163 2.68e-07 58.5 4QHD5@10239|Viruses,4QWUC@35237|dsDNA viruses no RNA stage,4QQGJ@28883|Caudovirales,4QMEN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_366421_2 1567485.A0A0B4SJN7_9CAUD 8.68e-28 110.0 4QBNJ@10239|Viruses,4QQAU@28883|Caudovirales,4QM09@10699|Siphoviridae 10699|Siphoviridae S Protein of unknown function (DUF2815) - - - - - - - - - - - - - k59_15667_4 665956.HMPREF1032_00686 7.94e-58 229.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,3WN92@541000|Ruminococcaceae 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_190943_1 857571.EA1_02132 6.99e-07 50.4 COG0393@1|root,COG0393@2|Bacteria,1RJ73@1224|Proteobacteria,1S6S1@1236|Gammaproteobacteria,3NNHZ@468|Moraxellaceae 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_190943_2 5722.XP_001312207.1 0.000945 48.9 COG1073@1|root,KOG1552@2759|Eukaryota 2759|Eukaryota O palmitoyl-(protein) hydrolase activity - - - - - - - - - - - - Hydrolase_4 k59_150736_1 1120956.JHZK01000003_gene270 5.04e-19 89.7 COG0438@1|root,COG0457@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,1N3R2@1224|Proteobacteria,2UBQN@28211|Alphaproteobacteria,1JPA4@119043|Rhodobiaceae 28211|Alphaproteobacteria M Glycosyltransferase family 17 - - 2.4.1.144 ko:K00737 ko00510,ko01100,map00510,map01100 M00075 R05986 - ko00000,ko00001,ko00002,ko01000,ko01003 - GT17 - F5_F8_type_C,Glyco_transf_17 k59_393149_1 1380391.JIAS01000005_gene2437 1.13e-42 155.0 COG5323@1|root,COG5323@2|Bacteria,1R0EP@1224|Proteobacteria,2TYQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - - k59_2197_2 1732201.A0A0N9N7I3_9CIRC 2.62e-25 109.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_231070_1 1458357.BG58_33125 3.49e-75 240.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2VP7E@28216|Betaproteobacteria,1KFK1@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_326791_1 1165094.RINTHH_3920 5.26e-55 185.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_366620_3 1141137.K4F7V6_9CAUD 6.58e-132 397.0 4QD9Y@10239|Viruses,4R02G@35237|dsDNA viruses no RNA stage,4QS1V@28883|Caudovirales,4QNWZ@10744|Podoviridae 10744|Podoviridae S Terminase-like family - - - - - - - - - - - - - k59_366620_4 398578.Daci_1943 1.55e-69 240.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria 1224|Proteobacteria M Membrane - - - - - - - - - - - - - k59_366622_1 694060.D2K053_9CAUD 3.58e-42 147.0 4QGB5@10239|Viruses,4QXR2@35237|dsDNA viruses no RNA stage,4QSQD@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_299072_1 1144313.PMI10_00666 6.23e-21 103.0 2EXRF@1|root,33R0W@2|Bacteria,4NXTF@976|Bacteroidetes,1IKRK@117743|Flavobacteriia,2NY20@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - CotH,Laminin_G_3 k59_258669_11 1297742.A176_00137 3.86e-10 68.9 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales 28221|Deltaproteobacteria L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_258669_12 1525715.IX54_11130 3.41e-38 135.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2UIHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Pathogenesis-related transcriptional factor and ERF protein - - - - - - - - - - - - AP2,HNH_3 k59_258669_13 575590.HMPREF0156_00660 1.51e-14 85.5 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_258669_17 40571.JOEA01000005_gene4014 4.78e-24 96.3 arCOG05626@1|root,32V4D@2|Bacteria,2I38M@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_165736_1 1283071.R9R4P3_9CAUD 1.75e-33 133.0 4QBMV@10239|Viruses,4QUU6@35237|dsDNA viruses no RNA stage,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_58361_1 1692257.A0A0K1RL39_9CIRC 2.18e-58 193.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_315992_1 246199.CUS_5176 8.34e-11 63.9 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WHV1@541000|Ruminococcaceae 186801|Clostridia K Belongs to the ParB family spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_368389_1 1177928.TH2_05253 2.22e-34 145.0 COG1511@1|root,COG3941@1|root,COG1511@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - DUF4175,TMP_2,Tape_meas_lam_C k59_316285_1 219305.MCAG_05502 3.57e-28 111.0 2EFG7@1|root,3398W@2|Bacteria,2ID0P@201174|Actinobacteria,4DGI7@85008|Micromonosporales 201174|Actinobacteria L Recombination endonuclease VII - - - - - - - - - - - - Endonuclease_7 k59_355950_2 285514.JNWO01000071_gene4 3.06e-29 119.0 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_247212_1 1477404.A0A023NGI3_9CAUD 9.8e-25 103.0 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_395065_1 10506.Q89379_PBCV1 3.96e-34 140.0 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage 10239|Viruses S ATPase activity - - - - - - - - - - - - - k59_44475_2 1121926.AXWO01000004_gene1187 2.25e-12 70.1 2B815@1|root,3218Y@2|Bacteria,2H57E@201174|Actinobacteria 201174|Actinobacteria S Rad52/22 family double-strand break repair protein - - - - - - - - - - - - Rad52_Rad22 k59_179748_2 8496.XP_006272557.1 1.05e-25 112.0 KOG1565@1|root,KOG1565@2759|Eukaryota,38HNS@33154|Opisthokonta,3BHFC@33208|Metazoa,3CY36@33213|Bilateria,48283@7711|Chordata,48Y4Z@7742|Vertebrata 33208|Metazoa OW collagen catabolic process MMP1 GO:0001503,GO:0001704,GO:0001706,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0006810,GO:0006887,GO:0006928,GO:0006955,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007369,GO:0007492,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0008270,GO:0009056,GO:0009653,GO:0009790,GO:0009888,GO:0009987,GO:0010033,GO:0010762,GO:0010763,GO:0012505,GO:0014910,GO:0014911,GO:0016043,GO:0016192,GO:0016477,GO:0016787,GO:0017171,GO:0019221,GO:0019538,GO:0022411,GO:0022617,GO:0023052,GO:0030141,GO:0030154,GO:0030198,GO:0030334,GO:0030335,GO:0030574,GO:0031334,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032459,GO:0032461,GO:0032501,GO:0032502,GO:0032879,GO:0032940,GO:0032963,GO:0034097,GO:0034774,GO:0035580,GO:0035987,GO:0036230,GO:0040011,GO:0040012,GO:0040017,GO:0042119,GO:0042221,GO:0042581,GO:0043062,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0043254,GO:0043299,GO:0043312,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044421,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0046914,GO:0048518,GO:0048522,GO:0048598,GO:0048646,GO:0048856,GO:0048869,GO:0048870,GO:0050789,GO:0050794,GO:0050896,GO:0050900,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051270,GO:0051272,GO:0051674,GO:0051716,GO:0060205,GO:0065007,GO:0070011,GO:0070013,GO:0070820,GO:0070887,GO:0071310,GO:0071345,GO:0071704,GO:0071840,GO:0097708,GO:0099503,GO:0140096,GO:1901564,GO:1904724,GO:2000145,GO:2000147 3.4.24.17,3.4.24.34,3.4.24.7,3.4.24.80 ko:K01388,ko:K01394,ko:K01402,ko:K07763,ko:K07994,ko:K07999 ko03320,ko04657,ko04668,ko04912,ko04926,ko05200,ko05202,ko05215,ko05219,ko05323,map03320,map04657,map04668,map04912,map04926,map05200,map05202,map05215,map05219,map05323 - - - ko00000,ko00001,ko01000,ko01002,ko04516 - - - Hemopexin,PG_binding_1,Peptidase_M10 k59_355954_1 237368.SCABRO_02736 8.94e-19 92.4 COG1749@1|root,COG1749@2|Bacteria,2IYJT@203682|Planctomycetes 203682|Planctomycetes N Flagellar hook protein FlgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_409104_1 999550.KI421507_gene939 2.38e-39 148.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_381086_2 1121946.AUAX01000009_gene4501 1.33e-13 71.2 COG1403@1|root,COG1403@2|Bacteria,2GMJV@201174|Actinobacteria,4DDMJ@85008|Micromonosporales 201174|Actinobacteria L endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_421694_3 1286632.P278_23670 1.19e-28 111.0 COG0528@1|root,COG0528@2|Bacteria,4NE8Z@976|Bacteroidetes,1HXVS@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_98884_1 706587.Desti_2197 1.69e-41 146.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,42WFA@68525|delta/epsilon subdivisions,2X5AZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pfam:Gp37_Gp68 - - - - - - - - - - - - DUF5131 k59_260790_1 1089453.GOSPT_118_00520 3.65e-08 65.5 COG0791@1|root,COG3583@1|root,COG3941@1|root,COG5283@1|root,COG0791@2|Bacteria,COG3583@2|Bacteria,COG3941@2|Bacteria,COG5283@2|Bacteria,2HFH1@201174|Actinobacteria,4GEMM@85026|Gordoniaceae 201174|Actinobacteria M domain protein - - - - - - - - - - - - - k59_409116_1 1732201.A0A0N9N7I3_9CIRC 9.65e-18 86.3 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_355984_1 935548.KI912159_gene124 2.8e-17 81.3 COG3740@1|root,COG3740@2|Bacteria,1NBQ9@1224|Proteobacteria,2UK6T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_263396_2 1139219.I569_00086 2.38e-14 74.3 COG3740@1|root,COG3740@2|Bacteria,1VH0Q@1239|Firmicutes,4HZC1@91061|Bacilli 91061|Bacilli S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_411567_1 1232447.BAHW02000038_gene2648 2.07e-05 48.1 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,26A6U@186813|unclassified Clostridiales 186801|Clostridia L DnaB-like helicase N terminal domain dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_411567_2 927704.SELR_18440 2.8e-06 56.6 COG3935@1|root,COG3935@2|Bacteria,1TQ65@1239|Firmicutes,4H6KQ@909932|Negativicutes 909932|Negativicutes L N-terminal phage replisome organiser (Phage_rep_org_N) - - - - - - - - - - - - Phage_rep_org_N k59_358983_3 448385.sce6271 2.03e-20 89.7 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,42PDG@68525|delta/epsilon subdivisions,2WKNJ@28221|Deltaproteobacteria,2Z1YT@29|Myxococcales 28221|Deltaproteobacteria L Resolvase, N terminal domain - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_143941_1 1589747.A0A0B5A4F6_9CAUD 1.23e-05 50.4 4QAKN@10239|Viruses,4QUC9@28883|Caudovirales,4QMGM@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_210590_1 257313.BP3384 2.39e-49 174.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,2VJZR@28216|Betaproteobacteria,3T6ZN@506|Alcaligenaceae 28216|Betaproteobacteria S to Bacillus subtilis pbsx phage terminase large subunit xtmB SWALL XTMB_BACSU (SWALL P39786) (433 aa) fasta scores E() 0.2, 21.58 id in 417 aa, and to Yersinia pestis - - - - - - - - - - - - Terminase_6,Terminase_6C k59_6207_2 1133022.I6NSG5_9CAUD 3.3e-09 60.8 4QBTT@10239|Viruses,4QVNB@35237|dsDNA viruses no RNA stage,4QQUU@28883|Caudovirales,4QKWB@10699|Siphoviridae 10699|Siphoviridae S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - - k59_101344_3 420324.KI911970_gene1460 6.36e-09 65.5 COG5301@1|root,COG5301@2|Bacteria,1N4CW@1224|Proteobacteria,2TYJK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage T7 tail fibre protein - - - - - - - - - - - - Phage_T7_tail k59_382652_1 1520935.A0A0H3UB63_9CIRC 5.72e-05 48.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_34123_1 382464.ABSI01000011_gene2609 2.3e-19 91.7 COG3119@1|root,COG3119@2|Bacteria,46UET@74201|Verrucomicrobia,2IU4V@203494|Verrucomicrobiae 203494|Verrucomicrobiae P C-terminal region of aryl-sulfatase - - - - - - - - - - - - Sulfatase,Sulfatase_C k59_263646_2 562982.HMPREF0432_01569 0.000472 47.4 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,3WE8F@539002|Bacillales incertae sedis 91061|Bacilli L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_345587_1 1120971.AUCA01000020_gene1013 1.89e-06 50.1 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,278JB@186823|Alicyclobacillaceae 91061|Bacilli L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_195077_3 1692255.A0A0K1RL52_9CIRC 3.32e-82 258.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_76897_1 648885.KB316282_gene1009 2.2e-49 167.0 COG0745@1|root,COG0745@2|Bacteria,1NG1V@1224|Proteobacteria,2UJ3D@28211|Alphaproteobacteria,1JYJE@119045|Methylobacteriaceae 28211|Alphaproteobacteria K Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Trans_reg_C k59_345594_1 90813.JQMT01000001_gene1510 6.55e-13 69.3 COG0494@1|root,COG0494@2|Bacteria,1N9TV@1224|Proteobacteria,1SG85@1236|Gammaproteobacteria 1236|Gammaproteobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_127114_2 1692244.A0A0K1RLR5_9CIRC 3.46e-82 255.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_183503_1 3067.XP_002953010.1 1.54e-10 68.9 COG0553@1|root,KOG0383@2759|Eukaryota,37PGJ@33090|Viridiplantae,34J5I@3041|Chlorophyta 3041|Chlorophyta B Chromo (CHRromatin Organisation MOdifier) domain - - 3.6.4.12 ko:K11643,ko:K14435 ko05165,ko05203,map05165,map05203 - - - ko00000,ko00001,ko01000,ko03036 - - - Chromo,Helicase_C,PHD,SNF2_N k59_265570_1 105154.Q9MBU6_9VIRU 4.26e-102 317.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_265570_3 1165094.RINTHH_3920 2.38e-80 252.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_265570_7 105154.Q9MBU6_9VIRU 4.41e-116 350.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_129133_1 240302.BN982_04101 1.48e-70 222.0 COG4974@1|root,COG4974@2|Bacteria,1V2D0@1239|Firmicutes,4HNZ7@91061|Bacilli 91061|Bacilli L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_22565_2 1121352.JHZP01000012_gene1726 4.05e-27 104.0 2AMM7@1|root,31CH8@2|Bacteria,1RJ8Y@1224|Proteobacteria,2VRYC@28216|Betaproteobacteria,2KR6W@206351|Neisseriales 206351|Neisseriales L Pyrimidine dimer DNA glycosylase - - 3.1.25.1 ko:K01161 - - - - ko00000,ko01000 - - - Pyr_excise k59_277528_1 1122201.AUAZ01000026_gene1209 8.76e-84 263.0 2C6N9@1|root,32RHI@2|Bacteria,1P488@1224|Proteobacteria,1SUTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_277528_2 490913.C4NTD5_9CAUD 2.34e-47 172.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_183685_1 220341.16501922 2.09e-101 308.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,3ZIQ8@590|Salmonella 1236|Gammaproteobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_79852_7 1333523.L593_06940 3.9e-09 58.2 arCOG02827@1|root,arCOG06550@1|root,arCOG02827@2157|Archaea,arCOG06550@2157|Archaea,2XUVV@28890|Euryarchaeota,23T3N@183963|Halobacteria 183963|Halobacteria S Domain of unknown function (DUF1508) - - - - - - - - - - - - DUF1508 k59_332013_1 1005048.CFU_1251 1.09e-31 120.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,472KM@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_197061_1 91464.S7335_1110 1.89e-14 75.9 2CC4J@1|root,2Z7W8@2|Bacteria,1G4C9@1117|Cyanobacteria 1117|Cyanobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_93370_3 797515.HMPREF9103_02430 5.01e-27 104.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_172877_1 1048207.F8UBT5_9CAUD 2.05e-14 75.1 4QH92@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_199976_3 1156919.QWC_31271 7.92e-35 126.0 2BA7A@1|root,323MC@2|Bacteria,1RIHY@1224|Proteobacteria,2VTIA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_333640_1 65393.PCC7424_0861 8.92e-58 190.0 COG0675@1|root,COG0675@2|Bacteria,1G0J6@1117|Cyanobacteria,3KJIS@43988|Cyanothece 1117|Cyanobacteria L TIGRFAM transposase, IS605 OrfB family - - - - - - - - - - - - OrfB_IS605,OrfB_Zn_ribbon k59_333640_2 1166948.JPZL01000001_gene2751 3.61e-05 53.5 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF k59_132379_2 710687.KI912270_gene2035 1.28e-06 58.9 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,2GKX9@201174|Actinobacteria,232JS@1762|Mycobacteriaceae 201174|Actinobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdE GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0051063,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN k59_279849_1 1123008.KB905697_gene3236 1.12e-08 61.6 COG3210@1|root,COG3210@2|Bacteria,4PPCP@976|Bacteroidetes 976|Bacteroidetes U Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_308435_1 633149.Bresu_1401 1.12e-20 92.8 COG0582@1|root,COG0582@2|Bacteria,1R7TF@1224|Proteobacteria,2U05X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase - - - - - - - - - - - - Phage_integrase k59_416070_1 1007105.PT7_P059 1.9e-54 185.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,3T3DM@506|Alcaligenaceae 28216|Betaproteobacteria S COG4626 Phage terminase-like protein, large subunit - - - - - - - - - - - - Terminase_1 k59_10781_1 44088.Q6VZJ4_CNPV 5.09e-41 150.0 4QB1C@10239|Viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_279853_3 1386089.N865_01210 1.98e-11 64.7 2CESS@1|root,33C6B@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_23 k59_279853_4 1386089.N865_03910 4.17e-15 72.0 2CC1Y@1|root,32G41@2|Bacteria,2GPTR@201174|Actinobacteria,4FHEV@85021|Intrasporangiaceae 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA - - - - - - - - - - - - Whib k59_51689_1 556269.ACDQ01000003_gene1356 7.82e-66 231.0 COG4733@1|root,COG4733@2|Bacteria,1PG9M@1224|Proteobacteria,2W1MG@28216|Betaproteobacteria,4782D@75682|Oxalobacteraceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_106072_1 1449342.JQMR01000001_gene118 2.96e-28 115.0 COG3774@1|root,COG3774@2|Bacteria,1V3YG@1239|Firmicutes,4HG22@91061|Bacilli,27GFB@186828|Carnobacteriaceae 91061|Bacilli M Glycosyltransferase sugar-binding region containing DXD motif - - - - - - - - - - - - Gly_transf_sug k59_241134_1 398720.MED217_05057 1.15e-19 94.4 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,1HWS1@117743|Flavobacteriia,2XHV2@283735|Leeuwenhoekiella 976|Bacteroidetes L DnaB-like helicase N terminal domain dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_228548_1 742733.HMPREF9469_05039 8.69e-57 204.0 28JED@1|root,2Z98K@2|Bacteria,1TW1U@1239|Firmicutes,24CFD@186801|Clostridia,2226E@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - GerE k59_430861_1 68170.KL590474_gene5989 9.85e-10 60.8 COG0546@1|root,COG0546@2|Bacteria,2ISR0@201174|Actinobacteria 201174|Actinobacteria S haloacid dehalogenase-like hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_241141_1 1986029.Q9MBM8_9VIRU 9.72e-31 120.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_241141_2 105154.Q9MBU3_9VIRU 8.12e-10 63.5 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_391081_1 478749.BRYFOR_07042 7.12e-07 59.7 COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia 186801|Clostridia E Asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_242604_3 1609634.A0A0C5AFV4_9VIRU 4.47e-71 232.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_242686_2 1540090.A0A0A0RMT0_9CAUD 1.41e-13 73.2 4QGVC@10239|Viruses,4QSS9@28883|Caudovirales,4QKG5@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_41810_1 642492.Clole_0946 1.2e-22 100.0 COG3935@1|root,COG3935@2|Bacteria,1W6YJ@1239|Firmicutes,24P7D@186801|Clostridia 186801|Clostridia L DnaD domain protein - - - - - - - - - - - - - k59_41810_2 1128421.JAGA01000004_gene2548 1.41e-64 221.0 COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_41810_3 1118055.CAGU01000029_gene20 1.64e-14 71.2 2E3AH@1|root,32YA0@2|Bacteria,1VGN7@1239|Firmicutes,25DV7@186801|Clostridia,22HSA@1570339|Peptoniphilaceae 186801|Clostridia S Protein of unknown function (DUF1064) - - - - - - - - - - - - DUF1064 k59_297905_6 105154.Q9MBU6_9VIRU 4.65e-193 558.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_284439_1 1120971.AUCA01000049_gene794 3.7e-30 124.0 COG1783@1|root,COG1783@2|Bacteria,1VK0H@1239|Firmicutes,4HQ2H@91061|Bacilli 91061|Bacilli S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_230352_1 156889.Mmc1_1690 8.19e-167 484.0 COG1783@1|root,COG1783@2|Bacteria,1MVJB@1224|Proteobacteria,2U2BM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_230352_2 1344012.ATMI01000052_gene1941 8.58e-37 131.0 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,1SF0N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_419257_1 314264.ROS217_23367 5.36e-39 142.0 28M7D@1|root,2ZAKV@2|Bacteria,1R6BC@1224|Proteobacteria,2U3UN@28211|Alphaproteobacteria,46P0U@74030|Roseovarius 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_392467_1 1123269.NX02_03850 8.07e-14 77.8 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,2TT3N@28211|Alphaproteobacteria,2K7A3@204457|Sphingomonadales 204457|Sphingomonadales S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_14633_6 869724.H6BI57_9CAUD 1.25e-56 198.0 4QBYN@10239|Viruses,4QZT8@35237|dsDNA viruses no RNA stage,4QR5G@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1128_1 371042.NG99_26205 1.66e-25 110.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,1RNR0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_406160_8 935837.JAEK01000054_gene1469 3.05e-44 160.0 28W6R@1|root,2ZI7D@2|Bacteria,1V1MZ@1239|Firmicutes,4HTYQ@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_365584_5 10726.Q6QGM0_BPT5 5.23e-20 84.7 4QBVU@10239|Viruses,4QS37@28883|Caudovirales,4QM21@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_14749_2 585.DR95_340 3.1e-31 122.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558,ko:K17398 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_82497_1 452471.Aasi_0533 3.36e-27 105.0 COG0431@1|root,COG0431@2|Bacteria,4NN31@976|Bacteroidetes,47SD0@768503|Cytophagia 976|Bacteroidetes S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_29970_3 1121937.AUHJ01000007_gene1934 8.59e-57 184.0 2DICG@1|root,302RI@2|Bacteria,1PVSB@1224|Proteobacteria,1STCY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_299419_1 397288.C806_04880 1.26e-46 174.0 COG4626@1|root,COG4626@2|Bacteria,1TPU1@1239|Firmicutes,248RI@186801|Clostridia,27IKB@186928|unclassified Lachnospiraceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_299534_1 187303.BN69_0214 1.59e-26 114.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,36X97@31993|Methylocystaceae 28211|Alphaproteobacteria L DNA polymerase alpha chain like domain dnaE GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_151149_1 1122225.AULQ01000009_gene341 8.86e-06 53.9 2EAST@1|root,334US@2|Bacteria,4NRGD@976|Bacteroidetes,1I583@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_218011_2 1618243.A0A0C5IAV0_9CIRC 4.43e-34 131.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_164472_1 489825.LYNGBM3L_53240 0.000368 42.0 2AQQ1@1|root,31FXK@2|Bacteria,1G7GC@1117|Cyanobacteria,1HBNM@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_164472_2 489825.LYNGBM3L_48900 5.58e-43 142.0 COG2929@1|root,COG2929@2|Bacteria,1G7VS@1117|Cyanobacteria,1HHKU@1150|Oscillatoriales 1117|Cyanobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_164472_3 1337936.IJ00_03610 2.12e-25 96.7 2E3JE@1|root,32YHU@2|Bacteria,1G9QB@1117|Cyanobacteria,1HSNQ@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_218014_2 999549.KI421513_gene494 1.11e-29 109.0 2EF8R@1|root,32W7B@2|Bacteria,1N6JW@1224|Proteobacteria,2UTFX@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_231431_1 1038860.AXAP01000015_gene2003 7.6e-101 334.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_231431_4 1038860.AXAP01000067_gene8427 6.01e-99 310.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_367139_2 1220714.L7TNN5_9CAUD 1.57e-47 163.0 4QF7M@10239|Viruses,4QYGN@35237|dsDNA viruses no RNA stage,4QSE1@28883|Caudovirales 28883|Caudovirales S AAA domain - - - - - - - - - - - - - k59_367139_3 1175654.A0A0S0NAE1_9CAUD 2.79e-29 114.0 4QB0T@10239|Viruses,4QV4X@35237|dsDNA viruses no RNA stage,4QPUT@28883|Caudovirales,4QKQK@10699|Siphoviridae 10699|Siphoviridae S Protein of unknown function (DUF669) - - - - - - - - - - - - - k59_97363_1 691965.D4P7K1_9CAUD 1.4e-21 90.5 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales,4QKRA@10699|Siphoviridae 10699|Siphoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_138507_1 85982.XP_007321836.1 1.57e-24 109.0 2END3@1|root,2SRUK@2759|Eukaryota,3ATWJ@33154|Opisthokonta,3PH88@4751|Fungi 4751|Fungi S Geminivirus Rep catalytic domain - - - - - - - - - - - - Gemini_AL1 k59_247413_2 1122962.AULH01000008_gene2218 9.79e-10 57.4 2BPEW@1|root,32I73@2|Bacteria,1Q1QK@1224|Proteobacteria,2VB3T@28211|Alphaproteobacteria,3711V@31993|Methylocystaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_395220_1 1192868.CAIU01000008_gene937 1.04e-39 145.0 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria,2UJ12@28211|Alphaproteobacteria,43KMC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_4450_1 596154.Alide2_1988 4.45e-22 92.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2VMDZ@28216|Betaproteobacteria,4A9K0@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_4450_2 596154.Alide2_1989 1.72e-108 317.0 COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,2VNWR@28216|Betaproteobacteria,4AIY7@80864|Comamonadaceae 28216|Betaproteobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_287500_2 1210884.HG799466_gene12970 3.76e-55 177.0 COG4725@1|root,COG4725@2|Bacteria,2J40U@203682|Planctomycetes 203682|Planctomycetes KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_356641_2 1415756.JQMY01000001_gene539 2.96e-15 71.6 2DPYN@1|root,333ZK@2|Bacteria,1NDFW@1224|Proteobacteria,2UIJG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_44947_1 1172188.KB911820_gene2878 1.71e-24 99.0 2FCH2@1|root,344KH@2|Bacteria,2H8XB@201174|Actinobacteria 201174|Actinobacteria S MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 k59_232999_1 1486472.A0A068F3I8_9CAUD 1.93e-149 444.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_58972_1 565653.EGBG_00901 1.81e-06 50.4 2EGZP@1|root,33ART@2|Bacteria,1VKPB@1239|Firmicutes,4HR69@91061|Bacilli,4B4BD@81852|Enterococcaceae 91061|Bacilli S YopX protein - - - - - - - - - - - - YopX k59_273830_2 649638.Trad_1811 1.13e-28 119.0 COG4974@1|root,COG4974@2|Bacteria,1WKPJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_integrase k59_193180_3 388051.AUFE01000035_gene4020 5.93e-07 50.4 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_73915_4 483219.LILAB_30055 6.45e-23 100.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales 28221|Deltaproteobacteria L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_58978_1 994479.GL877879_gene5184 1.76e-91 295.0 COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4E1I0@85010|Pseudonocardiales 201174|Actinobacteria U Type IV secretory pathway, VirB4 - - - - - - - - - - - - AAA_10,DUF87,PrgI k59_32248_1 292415.Tbd_2069 1.03e-25 102.0 COG3355@1|root,COG3355@2|Bacteria,1N3ME@1224|Proteobacteria,2VTXQ@28216|Betaproteobacteria 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - - k59_168478_1 1161401.ASJA01000008_gene1673 6.75e-18 89.7 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2U3WK@28211|Alphaproteobacteria 28211|Alphaproteobacteria D tape measure protein - - - - - - - - - - - - Peptidase_M15_4,Tape_meas_lam_C k59_263793_1 1795983.A0A140CTJ3_9CIRC 1.96e-25 107.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_88928_1 585531.HMPREF0063_11932 6.75e-13 73.9 COG0749@1|root,COG3378@1|root,COG0749@2|Bacteria,COG3378@2|Bacteria,2GM8R@201174|Actinobacteria,4DSZ0@85009|Propionibacteriales 201174|Actinobacteria L DNA polymerase family A polA2 - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A k59_47194_1 1465751.W8QN04_9VIRU 3.7e-44 166.0 4QFET@10239|Viruses,4QY0D@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_20517_1 1033739.CAEU01000065_gene108 0.000235 49.3 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,4HHWD@91061|Bacilli 91061|Bacilli S portal protein - - - - - - - - - - - - Phage_portal k59_345731_1 38727.Pavir.Da00281.1.p 0.000588 47.8 COG0515@1|root,2QR8F@2759|Eukaryota,37PCV@33090|Viridiplantae,3GAK3@35493|Streptophyta,3KPQM@4447|Liliopsida,3IF90@38820|Poales 35493|Streptophyta T Protein kinase domain - GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004675,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0005911,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007623,GO:0008150,GO:0008152,GO:0009506,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019199,GO:0019538,GO:0023052,GO:0030054,GO:0036211,GO:0038023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048511,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055044,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1 ko:K04733 ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164 M00686 - - ko00000,ko00001,ko00002,ko01000,ko01001 - - - LRRNT_2,LRR_8,Pkinase_Tyr k59_234705_4 870187.Thini_0411 9.78e-21 97.8 2EP1Y@1|root,33GNT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_182081_1 1161935.H9D1H7_9CAUD 1.84e-18 85.1 4QAYZ@10239|Viruses,4QVHQ@35237|dsDNA viruses no RNA stage,4QTY8@28883|Caudovirales,4QNUP@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_423998_1 428125.CLOLEP_01417 5.23e-31 117.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,3WMXK@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_77146_1 1292035.H476_2141 7.37e-30 118.0 COG3621@1|root,COG3621@2|Bacteria,1V83Q@1239|Firmicutes,24AVQ@186801|Clostridia 186801|Clostridia S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_370678_1 1545915.JROG01000004_gene1901 2.08e-05 51.2 2DSHN@1|root,33G5Q@2|Bacteria,1NGM3@1224|Proteobacteria,2UK0H@28211|Alphaproteobacteria,2K4KJ@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_210955_1 1161935.H9D1E7_9CAUD 2.81e-105 332.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_275970_3 596315.HMPREF0634_0794 2.69e-20 102.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,25QCY@186804|Peptostreptococcaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_20729_2 1477404.A0A023NHY6_9CAUD 4.36e-56 177.0 4QGJ1@10239|Viruses,4QXHU@35237|dsDNA viruses no RNA stage,4QTXB@28883|Caudovirales,4QNRR@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_220473_1 1254432.SCE1572_21755 2.01e-10 69.3 COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,1MWY7@1224|Proteobacteria,42V1G@68525|delta/epsilon subdivisions,2WRCZ@28221|Deltaproteobacteria,2YWCA@29|Myxococcales 28221|Deltaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_220473_9 553184.ATORI0001_1171 1.94e-35 157.0 COG1340@1|root,COG5280@1|root,COG5283@1|root,COG1340@2|Bacteria,COG5280@2|Bacteria,COG5283@2|Bacteria,2I8JB@201174|Actinobacteria,4CX1V@84998|Coriobacteriia 84998|Coriobacteriia S Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_220473_18 1463858.JOHR01000018_gene4396 0.000105 53.5 COG3266@1|root,COG3266@2|Bacteria,2I2V4@201174|Actinobacteria 201174|Actinobacteria M Parallel beta-helix repeats pelX - - - - - - - - - - - Beta_helix,CBM_2,CBM_35,CBM_6 k59_195435_1 511145.b4003 2.91e-71 229.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSI4@1236|Gammaproteobacteria,3XPH1@561|Escherichia 1236|Gammaproteobacteria T Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium zraS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_2 k59_8642_1 172088.AUGA01000071_gene7569 6.39e-31 126.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_103560_1 1225805.J7KGW1_9CAUD 9.09e-29 123.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_170130_1 652103.Rpdx1_2983 1.78e-26 104.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2UHEF@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_236486_4 1121017.AUFG01000020_gene2298 4.9e-25 99.8 COG2131@1|root,COG2131@2|Bacteria,2IJ94@201174|Actinobacteria,4FHCM@85021|Intrasporangiaceae 201174|Actinobacteria F MafB19-like deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_213616_1 313628.LNTAR_06169 6.59e-15 75.1 COG0459@1|root,COG0459@2|Bacteria 2|Bacteria O protein refolding groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_80387_1 882.DVU_2165 9.7e-34 121.0 COG0741@1|root,COG0741@2|Bacteria,1NAJM@1224|Proteobacteria,43233@68525|delta/epsilon subdivisions,2WX5F@28221|Deltaproteobacteria,2MD5A@213115|Desulfovibrionales 28221|Deltaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_170412_1 246196.MSMEI_6111 1.9e-07 57.0 COG0847@1|root,COG0847@2|Bacteria,2GJZ0@201174|Actinobacteria,232UE@1762|Mycobacteriaceae 201174|Actinobacteria L DNA polymerase III dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - BRCT,RNase_T,TerD k59_332162_1 428125.CLOLEP_01379 2.1e-56 191.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia,3WN6X@541000|Ruminococcaceae 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_103807_1 691965.D4P7C5_9CAUD 1.24e-65 216.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_197386_2 1444309.JAQG01000181_gene3496 6.68e-21 87.0 COG1733@1|root,COG1733@2|Bacteria,1VH3Q@1239|Firmicutes,4HNMI@91061|Bacilli,26Y63@186822|Paenibacillaceae 91061|Bacilli K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_22954_1 1477404.A0A023NFY5_9CAUD 1.19e-05 49.7 4QBY0@10239|Viruses,4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_426031_1 1297742.A176_07570 1.9e-05 49.3 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_80416_1 1123399.AQVE01000001_gene652 9.32e-25 107.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,45ZQV@72273|Thiotrichales 72273|Thiotrichales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526,ko:K03676 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03110,ko03400 - - - Glutaredoxin,Ribonuc_red_sm k59_129697_1 145579.REP_BPPHM 0.000149 50.8 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_362243_2 1003200.AXXA_04918 0.000359 45.1 COG1396@1|root,COG1396@2|Bacteria,1Q1NG@1224|Proteobacteria,2WHUM@28216|Betaproteobacteria,3T7B8@506|Alcaligenaceae 28216|Betaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3,HTH_31 k59_277828_1 1236000.L0AQZ2_9CAUD 6.08e-15 72.4 4QEGD@10239|Viruses,4QVU1@35237|dsDNA viruses no RNA stage,4QPN9@28883|Caudovirales,4QJCM@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_277828_2 693986.MOC_3408 3.35e-05 53.5 COG3378@1|root,COG4983@1|root,COG3378@2|Bacteria,COG4983@2|Bacteria,1MV7I@1224|Proteobacteria,2TRS2@28211|Alphaproteobacteria,1JS6R@119045|Methylobacteriaceae 28211|Alphaproteobacteria O TIGRFAM phage plasmid primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,Prim-Pol k59_237726_5 1122963.AUHB01000011_gene1373 1.04e-18 84.7 2CEI6@1|root,2ZED5@2|Bacteria,1RCK0@1224|Proteobacteria,2U5ND@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_160251_2 1618260.A0A0C5I2C5_9CIRC 3.08e-91 278.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_93290_1 742767.HMPREF9456_03356 2.15e-72 228.0 COG0175@1|root,COG0175@2|Bacteria,4PNYM@976|Bacteroidetes,2G11I@200643|Bacteroidia,230XX@171551|Porphyromonadaceae 2|Bacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_268233_1 742738.HMPREF9460_03963 1.96e-35 133.0 COG4675@1|root,COG5301@1|root,COG4675@2|Bacteria,COG5301@2|Bacteria,1VDP2@1239|Firmicutes,24P8K@186801|Clostridia 186801|Clostridia S tail collar domain protein - - - - - - - - - - - - - k59_105702_1 186617.M9M8L2_9VIRU 6.63e-23 102.0 4QFNI@10239|Viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_253504_1 479434.Sthe_3014 5.11e-53 188.0 COG0281@1|root,COG0281@2|Bacteria,2G65R@200795|Chloroflexi,27XFK@189775|Thermomicrobia 189775|Thermomicrobia C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_294955_2 1042163.BRLA_07p000010 6.34e-18 89.0 28KEB@1|root,3063N@2|Bacteria,1TZ4V@1239|Firmicutes,4I8BZ@91061|Bacilli,273D7@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_237750_1 1173028.ANKO01000084_gene935 9.93e-103 329.0 COG0286@1|root,COG0286@2|Bacteria,1G119@1117|Cyanobacteria,1H81R@1150|Oscillatoriales 1117|Cyanobacteria V N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_428006_2 981335.G4W934_9CAUD 4.96e-50 168.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_64965_2 545695.TREAZ_1034 2.29e-12 63.5 2A7RX@1|root,30WQU@2|Bacteria,2JAQ9@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_253689_1 279383.Q5DN23_9CAUD 1.93e-15 86.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_333744_4 1517416.IDAT_12825 9.73e-06 56.6 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,2QEXJ@267893|Idiomarinaceae 1236|Gammaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_93545_1 1136417.AZWE01000006_gene4264 6.61e-07 50.1 COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria,4DDJ1@85008|Micromonosporales 201174|Actinobacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_428007_1 221359.RS9916_37797 4.75e-13 72.0 COG1961@1|root,COG1961@2|Bacteria,1GRF1@1117|Cyanobacteria,1H0VP@1129|Synechococcus 1117|Cyanobacteria L Resolvase, N terminal domain - - - - - - - - - - - - Resolvase k59_10865_1 67356.KL575612_gene4917 3.4e-12 74.7 COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria 201174|Actinobacteria P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_338464_3 218851.Aquca_004_00688.1 6.99e-23 106.0 COG0553@1|root,KOG1001@2759|Eukaryota,37IVF@33090|Viridiplantae,3G7HD@35493|Streptophyta 35493|Streptophyta KL SWI SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like - - 2.3.2.27 ko:K15711 - - - - ko00000,ko01000,ko03400,ko04121 - - - HIRAN,Helicase_C,SNF2_N,zf-C3HC4,zf-C3HC4_3 k59_311756_2 1112212.JH584235_gene2495 7.59e-09 62.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2K0RQ@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_108884_1 691965.D4P7I3_9CAUD 9.41e-78 260.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_419047_2 983545.Glaag_4160 3.72e-13 66.6 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,466WC@72275|Alteromonadaceae 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_338475_1 1556290.A0A0A0RL96_9CAUD 1.82e-10 66.2 4QGMJ@10239|Viruses,4QSYG@28883|Caudovirales,4QM5B@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_41652_2 1307761.L21SP2_0719 0.000156 47.4 COG2189@1|root,COG4121@1|root,COG2189@2|Bacteria,COG4121@2|Bacteria,2J6CC@203691|Spirochaetes 203691|Spirochaetes L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_983_2 1532557.JL37_11180 6.73e-86 274.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,2VIPB@28216|Betaproteobacteria,3T56P@506|Alcaligenaceae 28216|Betaproteobacteria S Phage terminase large subunit (GpA) - - 3.1.21.4 ko:K21512 - - - - ko00000,ko01000 - - - Terminase_GpA k59_122451_1 1196031.ALEG01000021_gene704 1.32e-08 64.3 COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,1TQHQ@1239|Firmicutes,4HB2Y@91061|Bacilli,1ZAWI@1386|Bacillus 91061|Bacilli L helicase involved in DNA repair and perhaps also replication dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,RNase_T,ResIII k59_352265_2 118168.MC7420_3182 7.49e-11 63.9 COG0457@1|root,COG0457@2|Bacteria,1G15Q@1117|Cyanobacteria,1H7TC@1150|Oscillatoriales 1117|Cyanobacteria L tpr repeat - - - - - - - - - - - - CHAT,Sel1,TPR_10,TPR_8 k59_149745_3 762903.Pedsa_2413 3.47e-11 67.0 COG4675@1|root,COG4675@2|Bacteria,4NQJR@976|Bacteroidetes 976|Bacteroidetes S tail collar domain protein - - - - - - - - - - - - Collar k59_84366_1 345201.VF179_IIV3 9.28e-60 207.0 4QB98@10239|Viruses,4QWE3@35237|dsDNA viruses no RNA stage 10239|Viruses S Glycosyl transferase family 90 - - - - - - - - - - - - - k59_354329_1 1331060.RLDS_09125 2.16e-22 100.0 COG0827@1|root,COG0827@2|Bacteria,1MUZW@1224|Proteobacteria,2U4K0@28211|Alphaproteobacteria,2K6E3@204457|Sphingomonadales 204457|Sphingomonadales L Domain of unknown function (DUF4942) - - - - - - - - - - - - DUF4942 k59_286032_1 1472912.A0A023NGU4_9CAUD 6.22e-07 52.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0039638,GO:0044403,GO:0044406,GO:0044419,GO:0044423,GO:0044650,GO:0051704,GO:0098015,GO:0098024 - - - - - - - - - - - k59_110698_2 477641.MODMU_1443 3.34e-07 54.3 2E1PK@1|root,32X02@2|Bacteria,2GUS8@201174|Actinobacteria,4EWBT@85013|Frankiales 201174|Actinobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - DUF1353 k59_2925_1 1127518.H9C106_9CAUD 2.51e-89 277.0 4QC8M@10239|Viruses,4QWMX@35237|dsDNA viruses no RNA stage,4QQU8@28883|Caudovirales,4QIAN@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF1073) - - - - - - - - - - - - - k59_124162_1 986075.CathTA2_1798 7.15e-24 97.8 COG1351@1|root,COG1351@2|Bacteria,1TRHD@1239|Firmicutes,4HTFB@91061|Bacilli 91061|Bacilli F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_124162_3 1429046.RR21198_0302 0.000124 53.1 2EC0B@1|root,335ZK@2|Bacteria,2I86C@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_259479_1 1235792.C808_02638 9.47e-19 83.6 2C7AV@1|root,32S15@2|Bacteria,1V5N7@1239|Firmicutes,24HXV@186801|Clostridia 186801|Clostridia S COG NOG19595 non supervised orthologous group - - - - - - - - - - - - DUF3268 k59_206231_4 383372.Rcas_0037 1.92e-55 184.0 COG2003@1|root,COG2003@2|Bacteria,2G6BK@200795|Chloroflexi,375AQ@32061|Chloroflexia 32061|Chloroflexia L PFAM DNA repair protein RadC - - - ko:K03630 - - - - ko00000 - - - RadC k59_341360_1 1038860.AXAP01000015_gene2003 1.08e-16 85.5 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_166536_1 1131269.AQVV01000050_gene421 8.79e-87 276.0 COG0305@1|root,COG0305@2|Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_166536_8 714083.JH370377_gene2645 1.82e-05 53.9 COG0859@1|root,COG0859@2|Bacteria,2GSTW@201174|Actinobacteria,4FKGQ@85023|Microbacteriaceae 201174|Actinobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9,Hydrolase_like k59_247695_1 1122176.KB903537_gene1708 9.4e-29 122.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - AAA,AAA_5 k59_74054_2 1692253.A0A0K1RLM4_9CIRC 2.25e-30 125.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_261523_2 536019.Mesop_2095 2.64e-08 62.0 COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,2TUTK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_219030_2 1229753.K7QJI2_9CAUD 4e-54 200.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_219030_3 136084.Q9G0H0_9CAUD 1.51e-109 346.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_219030_5 1197951.I6R0Z0_9CAUD 2.65e-61 202.0 4QGZN@10239|Viruses,4R0FF@35237|dsDNA viruses no RNA stage,4QTUK@28883|Caudovirales 28883|Caudovirales S nuclease activity - - - - - - - - - - - - - k59_343528_2 1051675.G0YQH7_9CAUD 4.47e-126 382.0 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_125515_1 1112209.AHVZ01000008_gene2142 2.35e-37 138.0 COG0629@1|root,COG0629@2|Bacteria,1RC22@1224|Proteobacteria,1S2A9@1236|Gammaproteobacteria,3NRRN@468|Moraxellaceae 1236|Gammaproteobacteria L ERF superfamily - - - - - - - - - - - - ERF k59_86666_1 10752.A0MZB2_BPN4 6.22e-07 49.7 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_59061_1 428125.CLOLEP_01375 1.61e-128 409.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,3WNBH@541000|Ruminococcaceae 186801|Clostridia S DNA polymerase type-B family - - - - - - - - - - - - - k59_141515_1 1541065.JRFE01000019_gene3243 9.57e-09 63.2 COG0642@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,3VI2D@52604|Pleurocapsales 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_166545_2 1121441.AUCX01000022_gene766 1.73e-102 323.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,42QC5@68525|delta/epsilon subdivisions,2WVD2@28221|Deltaproteobacteria,2MCDS@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_273907_2 582744.Msip34_1670 3.21e-23 97.8 2CWYZ@1|root,32T0P@2|Bacteria,1MZEM@1224|Proteobacteria,2VUKY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_99857_2 470.IX87_05020 9.54e-27 110.0 COG3756@1|root,COG3756@2|Bacteria,1N7P7@1224|Proteobacteria,1SDRK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_114405_1 1121440.AUMA01000003_gene2956 1.08e-55 187.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,42X97@68525|delta/epsilon subdivisions,2WNMY@28221|Deltaproteobacteria,2MA3E@213115|Desulfovibrionales 28221|Deltaproteobacteria KL DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_6832_1 571166.KI421509_gene3812 1.36e-28 110.0 28PMA@1|root,2ZCAD@2|Bacteria,1RARQ@1224|Proteobacteria,2U6X3@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_370852_1 1403819.BATR01000162_gene5299 2.05e-84 272.0 COG0305@1|root,COG0305@2|Bacteria,46SKM@74201|Verrucomicrobia,2ITGD@203494|Verrucomicrobiae 203494|Verrucomicrobiae L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_276006_6 1244856.K4PY97_9CAUD 5.57e-72 229.0 4QBQ9@10239|Viruses,4QVS0@35237|dsDNA viruses no RNA stage,4QPFB@28883|Caudovirales,4QNDC@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF4043) - - - - - - - - - - - - - k59_303899_1 1121456.ATVA01000014_gene615 4.49e-11 60.8 2DMPB@1|root,32SV8@2|Bacteria,1NHUE@1224|Proteobacteria,430VU@68525|delta/epsilon subdivisions,2WW0U@28221|Deltaproteobacteria,2MCJ3@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_101924_1 585394.RHOM_02055 3.24e-48 167.0 COG0863@1|root,COG0863@2|Bacteria,1V0ZF@1239|Firmicutes,24CQV@186801|Clostridia 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_127505_1 1273103.NM10_13037 3.83e-16 80.1 COG3774@1|root,COG3774@2|Bacteria,1V3YG@1239|Firmicutes,4H4BC@909932|Negativicutes 909932|Negativicutes M Glycosyltransferase sugar-binding region containing DXD motif - - - - - - - - - - - - Gly_transf_sug k59_289764_2 411468.CLOSCI_00575 6.5e-21 93.2 COG0270@1|root,COG0270@2|Bacteria,1V3W2@1239|Firmicutes,24HK1@186801|Clostridia,22348@1506553|Lachnoclostridium 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K17398 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko03032,ko03036 - - - DNA_methylase k59_319879_1 377629.TERTU_2798 6.86e-11 71.2 COG3291@1|root,COG3291@2|Bacteria,1RCXG@1224|Proteobacteria,1S3CX@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Mycoplasma protein of unknown function, DUF285 - - - - - - - - - - - - DUF285 k59_331007_1 1215092.PA6_009_00300 5.83e-80 251.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria,1S6FI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_424505_1 348824.LPU83_0595 3.37e-72 239.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,4BNVZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_127740_2 1121378.KB899731_gene4028 6.47e-61 204.0 28MC2@1|root,2ZAQD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_360166_3 1236976.JCM16418_5007 3.79e-19 81.6 2EI5I@1|root,33BWX@2|Bacteria,1W0I2@1239|Firmicutes,4HYE0@91061|Bacilli,2715G@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_414021_1 1470593.BW43_03836 4.69e-32 122.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008446,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_414021_2 765913.ThidrDRAFT_3685 4.18e-67 213.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,1RMPQ@1236|Gammaproteobacteria,1WVWB@135613|Chromatiales 135613|Chromatiales GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_266247_3 1046627.BZARG_781 8.18e-14 67.4 COG3179@1|root,COG3179@2|Bacteria 2|Bacteria Q chitinase - - - - - - - - - - - - Peptidase_M15_4,Pesticin k59_116361_1 525909.Afer_1638 8.24e-55 194.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_49584_1 1410620.SHLA_4c001250 2.89e-30 121.0 COG0863@1|root,COG0863@2|Bacteria,1PCSC@1224|Proteobacteria,2U4M6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_147978_3 1618254.A0A0C5IBG4_9CIRC 2.83e-59 191.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_91407_4 1449065.JMLL01000011_gene2126 7.63e-13 73.2 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - KorB,ParBc k59_148263_1 1121889.AUDM01000002_gene305 1.54e-63 215.0 COG3378@1|root,COG3378@2|Bacteria,4NE1A@976|Bacteroidetes,1HY7C@117743|Flavobacteriia,2NTXA@237|Flavobacterium 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_148263_5 324925.Ppha_1670 1.27e-52 174.0 COG0847@1|root,COG0847@2|Bacteria 2|Bacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - 2.7.7.7,3.6.4.12 ko:K02337,ko:K02342,ko:K03654 ko00230,ko00240,ko01100,ko03018,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03018,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DEAD,Helicase_C,Helicase_C_2,RNase_T,RecQ_Zn_bind k59_184306_1 981336.F944_01665 1.14e-51 181.0 29XS2@1|root,30JHV@2|Bacteria,1Q0E2@1224|Proteobacteria,1THI7@1236|Gammaproteobacteria,3NQ98@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_148267_2 1122130.AUHN01000004_gene1207 5.36e-42 144.0 COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria 201174|Actinobacteria L single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_118351_12 240292.Ava_D0020 1.7e-50 168.0 2CPKU@1|root,32SJD@2|Bacteria,1G8WS@1117|Cyanobacteria,1HSH3@1161|Nostocales 1117|Cyanobacteria L 3' exoribonuclease, RNase T-like - - - - - - - - - - - - DUF5051 k59_52508_1 1218103.CIN01S_12_01780 0.000767 48.5 COG3210@1|root,COG3210@2|Bacteria,4P53W@976|Bacteroidetes,1I4P3@117743|Flavobacteriia,3ZT6H@59732|Chryseobacterium 976|Bacteroidetes U Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_118658_1 1173028.ANKO01000084_gene935 3.79e-123 383.0 COG0286@1|root,COG0286@2|Bacteria,1G119@1117|Cyanobacteria,1H81R@1150|Oscillatoriales 1117|Cyanobacteria V N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_295994_2 407392.A0MN19_9CAUD 1.27e-10 68.6 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_334233_1 1123269.NX02_21990 5.23e-79 249.0 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria,2UJ12@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_186550_1 665942.HMPREF1022_02940 3.03e-73 249.0 COG0553@1|root,COG0827@1|root,COG1040@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG1040@2|Bacteria,COG4646@2|Bacteria,1PGZG@1224|Proteobacteria,42NYW@68525|delta/epsilon subdivisions 1224|Proteobacteria L COG0827 Adenine-specific DNA methylase - - - - - - - - - - - - Eco57I,Helicase_C,N6_Mtase,ResIII,SNF2_N k59_11494_1 1500257.JQNM01000006_gene1783 2.42e-16 84.0 COG0175@1|root,COG0175@2|Bacteria,1PA2H@1224|Proteobacteria,2U5GP@28211|Alphaproteobacteria,4BD6I@82115|Rhizobiaceae 28211|Alphaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_133367_6 338966.Ppro_2849 5.11e-11 68.9 COG4447@1|root,COG4447@2|Bacteria,1PFCA@1224|Proteobacteria,42WUH@68525|delta/epsilon subdivisions,2WT3I@28221|Deltaproteobacteria 28221|Deltaproteobacteria G fibronectin type III domain protein - - - - - - - - - - - - fn3 k59_428509_1 574376.BAMA_14435 4.22e-07 52.0 COG3000@1|root,COG3000@2|Bacteria,1V2XN@1239|Firmicutes,4HFS5@91061|Bacilli,1ZGHZ@1386|Bacillus 91061|Bacilli I Fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_162009_1 1122201.AUAZ01000017_gene2960 2.84e-76 244.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_148505_1 1453505.JASY01000013_gene4303 5.91e-05 56.6 COG3291@1|root,COG5184@1|root,COG3291@2|Bacteria,COG5184@2|Bacteria,4PI2H@976|Bacteroidetes,1IA3E@117743|Flavobacteriia,2NXN5@237|Flavobacterium 976|Bacteroidetes DZ Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_148505_4 649747.HMPREF0083_00997 1.05e-30 115.0 COG3405@1|root,COG3405@2|Bacteria,1VBUA@1239|Firmicutes,4HMXV@91061|Bacilli,26Z1A@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - k59_296851_1 985255.APHJ01000021_gene1397 0.000525 48.9 COG1484@1|root,COG1484@2|Bacteria,4NTBU@976|Bacteroidetes,1I3WC@117743|Flavobacteriia,2P6VY@244698|Gillisia 976|Bacteroidetes L DNA-dependent DNA replication - - - - - - - - - - - - - k59_67646_4 388467.A19Y_0676 1.12e-17 90.9 COG0863@1|root,COG0863@2|Bacteria,1G3H1@1117|Cyanobacteria,1H9NU@1150|Oscillatoriales 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_323778_3 749414.SBI_06902 9.49e-26 116.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_215962_1 1197951.I6RT34_9CAUD 3.62e-227 639.0 4QGAG@10239|Viruses,4R0KB@35237|dsDNA viruses no RNA stage,4QUA4@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_310422_1 1609634.A0A0C5AFV4_9VIRU 8.38e-43 155.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_310422_3 1385658.U5KNR1_9VIRU 6.86e-23 99.8 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_40653_3 1336803.PHEL49_0908 2.55e-13 69.7 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1I2UG@117743|Flavobacteriia,3VWJ9@52959|Polaribacter 976|Bacteroidetes L Single-strand binding protein family ssb1 - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_40653_4 984262.SGRA_2017 6.12e-85 263.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,1INW2@117747|Sphingobacteriia 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_269919_1 691965.D4P7C5_9CAUD 1.66e-14 73.6 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_94576_1 867900.Celly_1396 1.19e-06 49.7 COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,1I1AC@117743|Flavobacteriia,1F930@104264|Cellulophaga 976|Bacteroidetes F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_175585_3 1692255.A0A0K1RL52_9CIRC 6.66e-22 97.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_148685_1 485915.Dret_1124 8.59e-17 79.3 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2M8YE@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM single-strand binding protein Primosomal replication protein n ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_40855_1 1227497.C491_12055 2.44e-07 58.5 COG0421@1|root,arCOG00050@2157|Archaea,2XUEJ@28890|Euryarchaeota,23T1E@183963|Halobacteria 183963|Halobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - - - - - - - - - - - Spermine_synth k59_41977_21 716544.wcw_0668 4.9e-29 110.0 2E6PI@1|root,3319W@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_41977_26 1115512.EH105704_01_02770 1.14e-48 165.0 COG0629@1|root,COG0629@2|Bacteria,1RC22@1224|Proteobacteria,1S2A9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ERF superfamily - - - - - - - - - - - - ERF k59_136663_1 1273707.L7TIC4_9CAUD 1.69e-44 149.0 4QFPC@10239|Viruses,4QXCG@35237|dsDNA viruses no RNA stage,4QPQC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_204029_10 1329516.JPST01000018_gene2646 3.56e-63 212.0 2BK7M@1|root,32EMH@2|Bacteria,1TZIR@1239|Firmicutes,4HRKW@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_204029_12 1329516.JPST01000018_gene2644 2.82e-35 142.0 2E9YU@1|root,3344C@2|Bacteria,1VF3Z@1239|Firmicutes,4HPTU@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_204029_14 945021.TEH_08600 1.91e-79 263.0 2DNRB@1|root,32YRN@2|Bacteria,1V4U4@1239|Firmicutes,4HJHB@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_230608_1 1283287.KB822587_gene924 0.000803 44.3 COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4DRD7@85009|Propionibacteriales 201174|Actinobacteria K Sigma-70, region 4 type 2 - - - ko:K02405,ko:K03090 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_122943_2 691965.D4P7L7_9CAUD 4.07e-264 766.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_122943_3 691965.D4P7L6_9CAUD 4.35e-64 202.0 4QFKG@10239|Viruses,4QV77@35237|dsDNA viruses no RNA stage,4QR6Q@28883|Caudovirales,4QMGT@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_122943_4 212035.YL247_MIMIV 4.15e-05 52.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage 10239|Viruses S HNH endonuclease - - - - - - - - - - - - - k59_190405_1 936152.F5A3C7_9CAUD 2.55e-70 227.0 4QG21@10239|Viruses,4QYV7@35237|dsDNA viruses no RNA stage,4QRQT@28883|Caudovirales,4QM3S@10699|Siphoviridae 10699|Siphoviridae S Phage terminase large subunit - - - - - - - - - - - - - k59_339366_1 153721.MYP_1853 1.12e-20 99.8 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NIIR@976|Bacteroidetes,47UJ0@768503|Cytophagia 976|Bacteroidetes L Exodeoxyribonuclease V, gamma subunit - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_325663_1 1235800.C819_00206 2.36e-42 152.0 COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,24A20@186801|Clostridia,27IMV@186928|unclassified Lachnospiraceae 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_354464_1 1165094.RINTHH_3920 3.1e-53 181.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_341482_1 1385658.U5KPZ6_9VIRU 7.86e-167 485.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_57561_1 1196323.ALKF01000200_gene2705 7.64e-50 168.0 COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,4H9QS@91061|Bacilli,26T1B@186822|Paenibacillaceae 91061|Bacilli F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_124338_10 159749.K0S5V7 9.98e-27 122.0 COG0553@1|root,KOG0386@2759|Eukaryota,2XAJK@2836|Bacillariophyta 2836|Bacillariophyta A bromo domain - - - ko:K11786 - - - - ko00000,ko01000,ko03021,ko03036 - - - Bromodomain,HSA,Helicase_C,SNF2_N k59_124338_12 696281.Desru_3573 2.7e-20 99.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2800 k59_124338_14 5865.XP_001610510.1 1.05e-11 79.0 COG0349@1|root,COG0749@1|root,KOG2373@1|root,KOG0950@2759|Eukaryota,KOG2206@2759|Eukaryota,KOG2373@2759|Eukaryota,3YBAR@5794|Apicomplexa,3KA43@422676|Aconoidasida,3Z42K@5863|Piroplasmida 422676|Aconoidasida JL DNA polymerase I - GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7,3.6.4.12 ko:K02335,ko:K17680 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03029,ko03032,ko03400 - - - AAA_25,DNA_pol_A,DNA_pol_A_exo1 k59_124338_16 1121468.AUBR01000099_gene3089 5.98e-30 114.0 2CDFK@1|root,2Z8BH@2|Bacteria,1V43D@1239|Firmicutes,24KG0@186801|Clostridia 186801|Clostridia H DNA N-6-adenine-methyltransferase - - - - - - - - - - - - Dam k59_124338_22 1007105.PT7_P068 5.98e-26 107.0 2DXNB@1|root,345PI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_380403_1 4533.OB0134G10020.1 5.98e-13 74.7 KOG2756@1|root,KOG2756@2759|Eukaryota,37NR1@33090|Viridiplantae,3GAF2@35493|Streptophyta,3KSP4@4447|Liliopsida,3I78Z@38820|Poales 35493|Streptophyta T Endonuclease/Exonuclease/phosphatase family - GO:0000287,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016604,GO:0016605,GO:0016787,GO:0016788,GO:0030145,GO:0031974,GO:0031981,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070013,GO:0070259,GO:0070260,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K19619 - - - - ko00000,ko01000,ko03400 - - - Exo_endo_phos,zf-RanBP k59_84787_1 762982.HMPREF9442_01170 2.72e-08 57.8 COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FRXC@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4417,ParBc k59_327934_1 47716.JOFH01000001_gene2364 2.04e-27 118.0 2DWRB@1|root,341IF@2|Bacteria,2ID68@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF5047) - - - - - - - - - - - - DUF5047 k59_57568_1 948565.AFFP02000003_gene1986 5.42e-05 50.8 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,1Y8ZS@135625|Pasteurellales 135625|Pasteurellales S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_394186_1 1165094.RINTHH_3920 2.66e-45 157.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_286478_1 742740.HMPREF9474_02274 4.42e-06 50.8 2DHA9@1|root,32U8X@2|Bacteria,1VD44@1239|Firmicutes,24NC3@186801|Clostridia,222SC@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_181101_1 1382359.JIAL01000001_gene923 0.000723 52.0 COG3170@1|root,COG4409@1|root,COG5306@1|root,COG3170@2|Bacteria,COG4409@2|Bacteria,COG5306@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia 2|Bacteria G Belongs to the peptidase S8 family exbB2 - - ko:K03561,ko:K12287,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko02000,ko02044 1.A.30.2.1 - - Big_3_2,DUF2341,Laminin_G_3,MotA_ExbB k59_126180_1 655097.C8ZKI4_9CAUD 3.06e-36 139.0 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_113105_1 1188256.BASI01000001_gene881 7.18e-11 63.5 COG1403@1|root,COG4733@1|root,COG1403@2|Bacteria,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,2TWI9@28211|Alphaproteobacteria 28211|Alphaproteobacteria D COG4733 Phage-related protein, tail component - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - Phage-tail_3 k59_317997_2 1463821.JOGR01000011_gene2247 3.47e-07 55.1 COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4EXSI@85014|Glycomycetales 201174|Actinobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE k59_344393_1 1232452.BAIB02000006_gene1051 7.97e-18 94.7 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,267MY@186813|unclassified Clostridiales 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_154139_1 266779.Meso_1199 2.05e-63 209.0 COG0553@1|root,COG0553@2|Bacteria,1R7CK@1224|Proteobacteria,2U228@28211|Alphaproteobacteria,43I7K@69277|Phyllobacteriaceae 28211|Alphaproteobacteria KL DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_167401_1 105154.Q9MBU6_9VIRU 4.13e-81 261.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_344398_2 1136535.I6NVP1_9CAUD 8.41e-18 85.9 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_302557_2 1300345.LF41_2410 7.96e-37 131.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria 1224|Proteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_318262_1 294631.Q5ZGB2_9CAUD 4.3e-26 105.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_262615_2 936152.F5A3C7_9CAUD 3.77e-97 300.0 4QG21@10239|Viruses,4QYV7@35237|dsDNA viruses no RNA stage,4QRQT@28883|Caudovirales,4QM3S@10699|Siphoviridae 10699|Siphoviridae S Phage terminase large subunit - - - - - - - - - - - - - k59_33541_1 1141137.K4F7F8_9CAUD 8.33e-10 61.6 4QD8P@10239|Viruses,4QZGQ@35237|dsDNA viruses no RNA stage,4QRTU@28883|Caudovirales,4QNRK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_219739_1 1123504.JQKD01000021_gene5682 6.61e-69 228.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_344693_1 316274.Haur_1369 1.02e-12 78.6 COG4372@1|root,COG5283@1|root,COG5412@1|root,COG4372@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,2G9J0@200795|Chloroflexi 2|Bacteria M TIGRFAM phage tail tape measure protein, TP901 family Z012_10445 - - ko:K01991,ko:K07161,ko:K07484 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - DDE_Tnp_IS66,DUF3084,LZ_Tnp_IS66,PhageMin_Tail,zf-IS66 k59_248773_1 1247963.JPHU01000011_gene834 6.17e-05 52.0 COG5434@1|root,COG5434@2|Bacteria,1QH2X@1224|Proteobacteria,2U1H2@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Beta_helix,Pectate_lyase_3 k59_329916_1 1121324.CLIT_8c00960 2e-26 116.0 COG3935@1|root,COG3935@2|Bacteria,1VIR6@1239|Firmicutes,24TSD@186801|Clostridia 186801|Clostridia L DnaD domain protein - - - - - - - - - - - - - k59_425044_1 399739.Pmen_0185 1.19e-11 68.2 COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1YD3S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - DUF4124,Peptidase_M23 k59_250745_1 1476390.A0A060RFG9_9CAUD 6.56e-07 55.5 4QBA5@10239|Viruses,4QXFW@35237|dsDNA viruses no RNA stage,4QPTU@28883|Caudovirales,4QN4A@10699|Siphoviridae 10699|Siphoviridae S AAA domain - - - - - - - - - - - - - k59_78924_1 172088.AUGA01000033_gene4641 2.98e-42 149.0 2CXZV@1|root,32T32@2|Bacteria,1N4R9@1224|Proteobacteria,2UM96@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_156773_1 1268240.ATFI01000007_gene432 7.32e-78 237.0 COG0863@1|root,COG0863@2|Bacteria,4NRE7@976|Bacteroidetes,2FP3W@200643|Bacteroidia,4APTU@815|Bacteroidaceae 976|Bacteroidetes L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_35725_1 272563.CD630_31510 5.32e-10 63.2 COG3935@1|root,COG3935@2|Bacteria,1VGQ6@1239|Firmicutes,24J03@186801|Clostridia,25UB2@186804|Peptostreptococcaceae 186801|Clostridia L DnaD domain protein - - - - - - - - - - - - - k59_331489_5 1382230.ASAP_0509 1.06e-40 152.0 COG0582@1|root,COG0582@2|Bacteria,1R3TM@1224|Proteobacteria,2TS94@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_235802_1 1096546.WYO_0201 2.71e-73 249.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,2UQEG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_90284_2 189425.PGRAT_19360 2.97e-17 82.8 COG0638@1|root,COG0638@2|Bacteria,1VTDM@1239|Firmicutes,4HURT@91061|Bacilli,26XQA@186822|Paenibacillaceae 91061|Bacilli O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine - - - - - - - - - - - - - k59_78951_1 1122165.AUHS01000021_gene369 4.22e-15 77.4 28H9R@1|root,2Z7MD@2|Bacteria,1MVTR@1224|Proteobacteria,1RMPH@1236|Gammaproteobacteria,1JCHJ@118969|Legionellales 118969|Legionellales S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_276946_1 345201.VF295_IIV3 4.38e-54 192.0 4QFET@10239|Viruses,4QY0D@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_128664_4 202954.BBNK01000034_gene3794 3.99e-21 90.1 2A3Q7@1|root,30S7S@2|Bacteria,1NP2K@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_221303_2 1465751.W8QF29_9VIRU 2.1e-59 196.0 4QAQY@10239|Viruses,4QUWR@35237|dsDNA viruses no RNA stage 10239|Viruses S acid-amino acid ligase activity - GO:0000209,GO:0002376,GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0004842,GO:0005575,GO:0006464,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010604,GO:0010605,GO:0010629,GO:0016032,GO:0016567,GO:0016740,GO:0018995,GO:0019012,GO:0019033,GO:0019042,GO:0019045,GO:0019046,GO:0019048,GO:0019049,GO:0019054,GO:0019056,GO:0019219,GO:0019222,GO:0019538,GO:0019787,GO:0020012,GO:0030430,GO:0030682,GO:0030683,GO:0031323,GO:0031326,GO:0031347,GO:0031348,GO:0032446,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034097,GO:0034340,GO:0035821,GO:0036211,GO:0039503,GO:0039506,GO:0039507,GO:0039548,GO:0039653,GO:0039656,GO:0039657,GO:0042025,GO:0042176,GO:0042221,GO:0043170,GO:0043207,GO:0043412,GO:0043656,GO:0043657,GO:0044003,GO:0044068,GO:0044092,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044359,GO:0044362,GO:0044403,GO:0044413,GO:0044414,GO:0044415,GO:0044419,GO:0044423,GO:0045087,GO:0045088,GO:0045732,GO:0045824,GO:0048518,GO:0048519,GO:0048583,GO:0048585,GO:0050690,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051817,GO:0051832,GO:0051833,GO:0051834,GO:0052008,GO:0052026,GO:0052031,GO:0052037,GO:0052043,GO:0052055,GO:0052056,GO:0052111,GO:0052167,GO:0052170,GO:0052173,GO:0052185,GO:0052188,GO:0052200,GO:0052204,GO:0052205,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052312,GO:0052368,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0065009,GO:0070647,GO:0071704,GO:0075136,GO:0075342,GO:0075528,GO:0080090,GO:0080134,GO:0140096,GO:1901564,GO:2001141 - - - - - - - - - - - k59_171738_2 330084.JNYZ01000003_gene2284 1.76e-37 147.0 2DWRB@1|root,341IF@2|Bacteria,2ID68@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF5047) - - - - - - - - - - - - DUF5047 k59_267340_2 93220.LV28_17515 1.54e-29 126.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2VIAB@28216|Betaproteobacteria,1K06D@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA ligase ligD - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_427069_1 1264700.L0MX86_9CAUD 1.33e-27 118.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_159326_1 1144310.PMI07_002360 4.06e-06 55.8 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria,4BP2Q@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_373379_4 1527515.A0A088FB58_9CAUD 5.35e-65 229.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_104837_1 1385658.U5KNR1_9VIRU 4.97e-43 152.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_279068_1 335283.Neut_1458 1.52e-30 120.0 COG5449@1|root,COG5449@2|Bacteria,1PUJN@1224|Proteobacteria,2VWIA@28216|Betaproteobacteria,374H6@32003|Nitrosomonadales 28216|Betaproteobacteria S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_172110_1 1230469.M5AAF0_9CAUD 7.23e-05 45.4 4QGP7@10239|Viruses,4QWWZ@35237|dsDNA viruses no RNA stage,4QQ0Q@28883|Caudovirales,4QMNP@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_294093_1 563031.HMPREF0666_01143 0.000369 51.2 2EXRF@1|root,33R0W@2|Bacteria,4NXTF@976|Bacteroidetes,2FQ6B@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_282157_2 1280944.HY17_04705 1.41e-08 64.3 2E8SI@1|root,3333B@2|Bacteria,1N7MG@1224|Proteobacteria,2UJSF@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_418004_1 1033732.CAHI01000035_gene2784 7.01e-09 62.0 COG3378@1|root,COG3378@2|Bacteria,4NE1A@976|Bacteroidetes,2FPTD@200643|Bacteroidia,22V3C@171550|Rikenellaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_120020_1 565664.EFXG_01503 8.71e-75 229.0 COG4725@1|root,COG4725@2|Bacteria,1TUQ2@1239|Firmicutes,4ICQ0@91061|Bacilli,4B5D0@81852|Enterococcaceae 91061|Bacilli KT MT-A70 - - - - - - - - - - - - MT-A70 k59_107541_1 1123250.KB908413_gene338 5.22e-26 112.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H2EZ@909932|Negativicutes 909932|Negativicutes L DNA polymerase - - - - - - - - - - - - DNA_pol_A k59_134827_2 1477404.A0A023NGK2_9CAUD 6.42e-36 130.0 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QNFC@10744|Podoviridae 10744|Podoviridae S hydrolase activity - - - - - - - - - - - - - k59_12921_7 575540.Isop_2434 6.3e-117 367.0 COG3087@1|root,COG3087@2|Bacteria,2IX3F@203682|Planctomycetes 203682|Planctomycetes D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_12940_1 1294273.roselon_00951 1.27e-10 69.3 COG0438@1|root,COG0463@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,1QWAI@1224|Proteobacteria,2TSIH@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyltransferase WbsX - - - - - - - - - - - - Glyco_tran_WbsX,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2 k59_107585_1 1134445.AJJM01000011_gene3537 9.86e-39 143.0 2CHG1@1|root,32YZS@2|Bacteria,2IRMN@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_418052_2 1385658.U5KNR1_9VIRU 2.4e-28 114.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_387199_1 267608.RSc3236 9.98e-21 92.8 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,1KAW7@119060|Burkholderiaceae 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_120098_1 279808.SH1779 1.19e-14 75.9 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4HAIF@91061|Bacilli,4H091@90964|Staphylococcaceae 91061|Bacilli L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_418065_2 1475143.W8SNN0_9CIRC 6.69e-34 133.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_282217_1 67257.JODR01000002_gene1131 7.86e-13 71.6 COG2453@1|root,COG2453@2|Bacteria,2IHXA@201174|Actinobacteria 201174|Actinobacteria T phosphatase - - - - - - - - - - - - Y_phosphatase k59_41370_1 1054461.G0XNV9_9CAUD 6.33e-05 46.6 4QHPY@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QSXS@28883|Caudovirales,4QNJ2@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_68317_1 1636270.A0A0E3JPD6_9CAUD 6.57e-29 120.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_122172_4 100901.wOo_06050 4.72e-10 60.8 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2TSDM@28211|Alphaproteobacteria,47F3H@766|Rickettsiales 766|Rickettsiales F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_338138_1 1517681.HW45_02700 6.46e-12 72.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1QZAD@1224|Proteobacteria,1RYP3@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_365062_1 691965.D4P7L3_9CAUD 3.42e-57 194.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage,4QQ8R@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_189613_3 1452718.JBOY01000021_gene719 5.35e-79 278.0 COG3378@1|root,COG3378@2|Bacteria,1QVIS@1224|Proteobacteria,1S02S@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Psort location Cytoplasmic, score - - - ko:K06919 - - - - ko00000 - - - Prim-Pol,Toprim_3,Toprim_4 k59_270550_3 1609634.A0A0C5ANA6_9VIRU 9.6e-07 50.8 4QCA6@10239|Viruses,4QUMI@29258|ssDNA viruses,4QP4E@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_685_1 1538644.KO02_12220 7.29e-47 171.0 COG0503@1|root,COG3170@1|root,COG0503@2|Bacteria,COG3170@2|Bacteria 2|Bacteria NU translation initiation factor activity apt - 2.4.2.7,3.1.26.12 ko:K00759,ko:K02945,ko:K08086,ko:K08300,ko:K08301,ko:K20276 ko00230,ko01100,ko02024,ko03010,ko03018,map00230,map01100,map02024,map03010,map03018 M00178,M00394 R00190,R01229,R04378 RC00063 br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011,ko03019,ko04147 - - - Pribosyltran k59_149217_2 520999.PROVALCAL_02622 2.11e-24 108.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,3Z7RA@586|Providencia 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_81823_1 1328030.S0A2M2_9CAUD 2.79e-50 169.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_81823_2 908937.Prede_1226 4.22e-47 164.0 COG0863@1|root,COG0863@2|Bacteria,4NZ6D@976|Bacteroidetes,2G31R@200643|Bacteroidia 976|Bacteroidetes L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_297500_1 1266908.AQPB01000051_gene2445 4.48e-38 132.0 2AT0I@1|root,31IGD@2|Bacteria,1NAE0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_365219_1 160488.PP_2273 5.73e-18 87.8 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,1SJP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase family A - - - - - - - - - - - - DNA_pol_A k59_203702_1 1618256.A0A0C5IM93_9CIRC 1.06e-24 108.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_405777_1 742821.HMPREF9464_01832 2.44e-05 47.8 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2VX9U@28216|Betaproteobacteria 28216|Betaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_405777_2 1432056.X781_8090 5.16e-34 134.0 COG4653@1|root,COG4653@2|Bacteria,1MYMH@1224|Proteobacteria,1RR5E@1236|Gammaproteobacteria,1Y809@135625|Pasteurellales 135625|Pasteurellales S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_162828_1 596153.Alide_3553 1.93e-107 334.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,2VIPB@28216|Betaproteobacteria,4ACRF@80864|Comamonadaceae 28216|Betaproteobacteria S terminase GpA - - 3.1.21.4 ko:K21512 - - - - ko00000,ko01000 - - - Terminase_GpA k59_162828_2 42565.FP66_04520 1.07e-05 51.2 COG4220@1|root,COG4220@2|Bacteria,1RFQ1@1224|Proteobacteria,1S33Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA Packaging nohB - - ko:K22014 - - - - ko00000 - - - Phage_Nu1 k59_81968_1 1235793.C809_02225 1.39e-41 151.0 COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia 186801|Clostridia S Mu-like prophage protein gp29 - - - - - - - - - - - - - k59_420349_1 575589.HMPREF0018_02856 5.83e-13 71.6 COG5527@1|root,COG5527@2|Bacteria,1RD9C@1224|Proteobacteria,1S4ZG@1236|Gammaproteobacteria,3NJHN@468|Moraxellaceae 1236|Gammaproteobacteria L Initiator Replication protein - - - - - - - - - - - - Rep_3 k59_70965_7 646529.Desaci_1301 6.28e-147 432.0 COG4653@1|root,COG4653@2|Bacteria,1TS6A@1239|Firmicutes,24994@186801|Clostridia,266IV@186807|Peptococcaceae 186801|Clostridia S TIGRFAM phage major capsid protein, HK97 family - - - - - - - - - - - - Phage_capsid k59_259064_1 1122176.KB903543_gene601 6.68e-36 143.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,4NF8P@976|Bacteroidetes,1IPIQ@117747|Sphingobacteriia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_380103_1 1379713.S5SYD9_9CIRC 4.67e-30 114.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_327238_10 575605.ACQN01000003_gene660 1.54e-40 158.0 COG1061@1|root,COG1061@2|Bacteria,1TQ62@1239|Firmicutes,4HAJ1@91061|Bacilli,3F3YQ@33958|Lactobacillaceae 91061|Bacilli L Helicase C-terminal domain protein - - - - - - - - - - - - Helicase_C,ResIII k59_231379_1 1415780.JPOG01000001_gene2862 1.63e-12 75.9 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1X31C@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_231379_2 1268303.RHODMAR_5061 2.05e-06 50.1 2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4G1ER@85025|Nocardiaceae 201174|Actinobacteria S Lsr2 lsr2 - - - - - - - - - - - Lsr2 k59_231381_2 1168478.I6RT73_9CAUD 1.54e-29 116.0 4QG21@10239|Viruses,4QYV7@35237|dsDNA viruses no RNA stage,4QRQT@28883|Caudovirales,4QM3S@10699|Siphoviridae 10699|Siphoviridae S Phage terminase large subunit - - - - - - - - - - - - - k59_191369_1 556269.ACDQ01000003_gene1356 1.61e-121 396.0 COG4733@1|root,COG4733@2|Bacteria,1PG9M@1224|Proteobacteria,2W1MG@28216|Betaproteobacteria,4782D@75682|Oxalobacteraceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_141001_2 679191.HMPREF9018_0882 1.63e-20 88.6 28HFG@1|root,2Z7RJ@2|Bacteria,4NFNY@976|Bacteroidetes,2FKZK@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1599 k59_395293_1 720554.Clocl_0134 4.01e-28 124.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,3WGP3@541000|Ruminococcaceae 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_409442_1 145579.CAPSD_BPPHM 9.58e-138 412.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_44790_1 1125863.JAFN01000001_gene3558 1.11e-07 58.5 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria,1RM55@1224|Proteobacteria,430PQ@68525|delta/epsilon subdivisions,2WVMQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Prophage tail length tape measure protein - - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_166295_1 1540221.JQNI01000004_gene166 3.07e-31 126.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_421961_1 1504822.CCNO01000015_gene594 4.16e-115 356.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_4327_1 691965.D4P7I3_9CAUD 8.46e-39 148.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_356434_1 375286.mma_2723 1.2e-09 65.5 COG4733@1|root,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,2VJS7@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_328918_15 926550.CLDAP_27370 4.6e-07 63.5 COG1520@1|root,COG1520@2|Bacteria,2G945@200795|Chloroflexi 200795|Chloroflexi S PQQ-like domain - - - - - - - - - - - - - k59_328918_17 262543.Exig_1185 1.32e-11 73.6 COG0739@1|root,COG3103@1|root,COG0739@2|Bacteria,COG3103@2|Bacteria,1TRWJ@1239|Firmicutes,4HWZ3@91061|Bacilli 91061|Bacilli MT peptidase - - - - - - - - - - - - Peptidase_M23,SH3_3 k59_328918_21 693661.Arcve_1359 1.65e-05 59.3 COG3291@1|root,COG3979@1|root,arCOG02499@1|root,arCOG02552@1|root,arCOG03439@1|root,arCOG02499@2157|Archaea,arCOG02552@2157|Archaea,arCOG03439@2157|Archaea,arCOG03504@2157|Archaea,arCOG07581@2157|Archaea,2XXWR@28890|Euryarchaeota 28890|Euryarchaeota P PFAM periplasmic copper-binding - - - - - - - - - - - - Beta_helix,NosD,PKD k59_328918_25 641112.ACOK01000113_gene2079 1.6e-07 65.5 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,3WH3F@541000|Ruminococcaceae 186801|Clostridia E Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail,TMP k59_155664_1 326424.FRAAL3309 1.52e-11 70.1 2AUNZ@1|root,31KBW@2|Bacteria,2GP4I@201174|Actinobacteria,4ESY9@85013|Frankiales 201174|Actinobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - DUF2786 k59_144697_1 1498011.A0A096XUT2_9CAUD 3.94e-09 58.9 4QAK6@10239|Viruses,4QRSI@28883|Caudovirales,4QNEJ@10744|Podoviridae 10744|Podoviridae S Pfam:DUF5309 - - - - - - - - - - - - - k59_412039_2 1437824.BN940_02881 3.95e-35 132.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,2VJZR@28216|Betaproteobacteria,3T6ZN@506|Alcaligenaceae 28216|Betaproteobacteria S to Bacillus subtilis pbsx phage terminase large subunit xtmB SWALL XTMB_BACSU (SWALL P39786) (433 aa) fasta scores E() 0.2, 21.58 id in 417 aa, and to Yersinia pestis - - - - - - - - - - - - Terminase_6,Terminase_6C k59_370818_2 397290.C810_01484 1.91e-48 166.0 2CWXD@1|root,32T0J@2|Bacteria,1VCVP@1239|Firmicutes,24MPK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_330962_2 411460.RUMTOR_01348 3.32e-89 284.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_330962_3 742740.HMPREF9474_02272 4.77e-245 693.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,222GA@1506553|Lachnoclostridium 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_89554_2 331627.Q2NPB1_9CAUD 5e-11 63.5 4QB0C@10239|Viruses,4QW7S@35237|dsDNA viruses no RNA stage,4QPK3@28883|Caudovirales,4QI2J@10662|Myoviridae 10662|Myoviridae S Endodeoxyribonuclease RusA - - - - - - - - - - - - - k59_7058_1 345201.RPB1_IIV3 3.22e-202 604.0 4QARB@10239|Viruses,4QV3H@35237|dsDNA viruses no RNA stage 10239|Viruses S RNA polymerase Rpb1, domain 3 - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_34885_1 313596.RB2501_01425 5.02e-147 441.0 COG5545@1|root,COG5545@2|Bacteria,4PMA3@976|Bacteroidetes,1IJP7@117743|Flavobacteriia 976|Bacteroidetes L VirE N-terminal domain - - - - - - - - - - - - DUF3987,PriCT_2,VirE,VirE_N k59_412295_1 706587.Desti_2197 4.17e-43 155.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,42WFA@68525|delta/epsilon subdivisions,2X5AZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pfam:Gp37_Gp68 - - - - - - - - - - - - DUF5131 k59_127678_2 1231190.NA8A_04345 1.05e-05 46.2 COG4197@1|root,COG4197@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - - - - - - - - - - YdaS_antitoxin k59_222222_1 690585.JNNU01000002_gene4480 1.82e-07 57.0 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - CHU_C,Flg_new,SprB k59_252050_1 1385658.U5KPZ6_9VIRU 2.02e-79 259.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_91727_1 1040989.AWZU01000019_gene1844 3.09e-08 58.9 COG4675@1|root,COG4675@2|Bacteria,1MYXI@1224|Proteobacteria,2V8W8@28211|Alphaproteobacteria,3JZFN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_348700_1 1120985.AUMI01000001_gene2164 1.07e-10 69.3 COG5281@1|root,COG5281@2|Bacteria,1TPWF@1239|Firmicutes,4H3NF@909932|Negativicutes 909932|Negativicutes S tape measure - - - - - - - - - - - - - k59_266561_1 1380393.JHVP01000008_gene4711 2.3e-46 174.0 COG2730@1|root,COG2730@2|Bacteria,2IJWB@201174|Actinobacteria 201174|Actinobacteria G Putative collagen-binding domain of a collagenase - - - - - - - - - - - - Collagen_bind_2,DUF4038 k59_170845_1 391613.RTM1035_18000 2.34e-17 87.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,46QCA@74030|Roseovarius 28211|Alphaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_148321_1 176652.261R_IIV6 2.03e-06 56.2 4QGKQ@10239|Viruses,4QYNE@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_91737_1 991905.SL003B_3788 5.69e-13 70.5 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2UDUF@28211|Alphaproteobacteria 28211|Alphaproteobacteria G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_384852_4 1469607.KK073768_gene2405 1.89e-06 50.8 COG1403@1|root,COG1403@2|Bacteria,1G2XW@1117|Cyanobacteria,1HQGV@1161|Nostocales 1117|Cyanobacteria V RRXRR protein - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_116633_1 89187.ISM_12695 1.91e-20 90.1 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,2TU8N@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_222458_1 345201.TOP2_IIV3 1.31e-112 355.0 4QDCP@10239|Viruses,4QVJZ@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA gyrase B - GO:0005575,GO:0032991 - - - - - - - - - - - k59_91752_2 1429767.W6B150_9CAUD 2.7e-34 133.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_130067_1 1071679.BG57_13775 2.72e-05 47.8 28KVW@1|root,32QUN@2|Bacteria,1N71S@1224|Proteobacteria,2VZCS@28216|Betaproteobacteria,1K2Z7@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_130067_3 292415.Tbd_0749 4.45e-36 141.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria,1KSGS@119069|Hydrogenophilales 119069|Hydrogenophilales S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_170870_3 870187.Thini_0411 1.5e-28 118.0 2EP1Y@1|root,33GNT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_91760_3 556268.OFAG_00310 8.69e-14 70.9 COG2932@1|root,COG2932@2|Bacteria,1PIRG@1224|Proteobacteria,2VSWM@28216|Betaproteobacteria 28216|Betaproteobacteria K peptidase - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_173361_1 1237149.C900_05366 2.05e-15 80.9 COG3740@1|root,COG3740@2|Bacteria,4NDXV@976|Bacteroidetes,47V54@768503|Cytophagia 976|Bacteroidetes S Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_416397_1 484895.A9J6W7_BPLUZ 4.05e-29 122.0 4QB4B@10239|Viruses,4QWC6@35237|dsDNA viruses no RNA stage,4QQNI@28883|Caudovirales,4QNPA@10744|Podoviridae 10744|Podoviridae S Glutamine amidotransferase domain - - - - - - - - - - - - - k59_295551_1 1217714.F975_01901 2.66e-24 107.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RPEK@1236|Gammaproteobacteria,3NMHD@468|Moraxellaceae 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_401659_1 1288494.EBAPG3_10510 4.55e-36 129.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,37329@32003|Nitrosomonadales 28216|Betaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_334008_1 399739.Pmen_0185 5.19e-14 74.3 COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1YD3S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - DUF4124,Peptidase_M23 k59_39231_1 1236000.L0AQQ6_9CAUD 2.43e-226 650.0 4QB9Y@10239|Viruses,4QWGZ@35237|dsDNA viruses no RNA stage,4QPTT@28883|Caudovirales,4QJD7@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_386077_5 1111121.HMPREF1247_1240 0.000138 49.7 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,2I92I@201174|Actinobacteria,4CYFU@84998|Coriobacteriia 84998|Coriobacteriia S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_173388_2 1120973.AQXL01000114_gene718 3.73e-08 57.8 COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,4H9TF@91061|Bacilli,2786W@186823|Alicyclobacillaceae 91061|Bacilli L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_52194_1 1379708.S5SYC3_9CIRC 9.34e-30 119.0 4QASI@10239|Viruses,4QUM7@29258|ssDNA viruses 10239|Viruses L Geminivirus coat protein/nuclear export factor BR1 family - GO:0005575,GO:0018995,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0042025,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_39643_3 1414766.A0A0A0P1Q9_9VIRU 2.66e-35 127.0 4QAU9@10239|Viruses 10239|Viruses S Single-strand binding protein family - - - - - - - - - - - - - k59_133494_1 1385658.U5KPZ6_9VIRU 3.97e-49 170.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_133494_2 105154.Q9MBU3_9VIRU 2.56e-10 66.2 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_133494_5 1165094.RINTHH_3920 7.37e-75 238.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_238333_2 414684.RC1_4018 0.000793 46.2 COG2227@1|root,COG2227@2|Bacteria,1QUP9@1224|Proteobacteria,2TW2X@28211|Alphaproteobacteria,2JTFV@204441|Rhodospirillales 204441|Rhodospirillales H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_390492_1 1121870.AUAA01000056_gene1153 1.08e-149 439.0 COG3378@1|root,COG3378@2|Bacteria,4NG1J@976|Bacteroidetes,1I78Y@117743|Flavobacteriia 976|Bacteroidetes S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_242190_2 1035839.AFNK01000036_gene1221 2.31e-11 65.9 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1Y8P1@135625|Pasteurellales 135625|Pasteurellales K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_390509_4 1357732.A0A059PYE0_9CAUD 2.91e-23 97.8 4QBFR@10239|Viruses,4QV1E@35237|dsDNA viruses no RNA stage,4QPRX@28883|Caudovirales,4QNJQ@10744|Podoviridae 10744|Podoviridae S ERF superfamily - - - - - - - - - - - - - k59_188939_1 1127518.H9C0Y5_9CAUD 4.83e-34 134.0 4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses no RNA stage,4QR8A@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_161961_6 326424.FRAAL2754 2.28e-57 196.0 28HEE@1|root,2Z7QU@2|Bacteria,2I1I5@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_81077_1 345201.TOP2_IIV3 1.64e-82 273.0 4QDCP@10239|Viruses,4QVJZ@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA gyrase B - GO:0005575,GO:0032991 - - - - - - - - - - - k59_283321_5 1492922.GY26_12325 0.000121 49.3 COG4675@1|root,COG4675@2|Bacteria,1RESM@1224|Proteobacteria,1S7DU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tail collar domain protein - - - - - - - - - - - - DUF3751 k59_418184_1 105154.Q9MBU6_9VIRU 5.35e-117 353.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_325183_1 1385658.U5KPZ6_9VIRU 6.96e-158 461.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_325183_4 105154.Q9MBU3_9VIRU 1.31e-11 68.6 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_325183_6 1385658.U5KNR1_9VIRU 6e-36 132.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_352301_1 1524880.A0A076G6J2_9VIRU 1.03e-106 324.0 4QD9Y@10239|Viruses 10239|Viruses S Pfam:Terminase_6C - - - - - - - - - - - - - k59_284464_3 257310.BB3529 0.00037 43.9 2CDBS@1|root,2ZXQ7@2|Bacteria,1P68E@1224|Proteobacteria,2W58M@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_176512_2 1038860.AXAP01000067_gene8427 1.73e-09 59.7 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_109119_1 1550091.JROE01000002_gene789 4.87e-06 53.9 COG2189@1|root,COG2189@2|Bacteria,4NGRD@976|Bacteroidetes,1J09G@117747|Sphingobacteriia 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_109119_2 1385935.N836_35740 5.16e-12 66.6 COG0270@1|root,COG0270@2|Bacteria,1GE2G@1117|Cyanobacteria,1HFNE@1150|Oscillatoriales 1117|Cyanobacteria L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_230402_1 1123514.KB905901_gene62 1.89e-11 64.7 COG3440@1|root,COG3440@2|Bacteria 2|Bacteria V regulation of methylation-dependent chromatin silencing - - - ko:K07454 - - - - ko00000 - - - HNH,HNH_2,SAD_SRA k59_95743_1 1300345.LF41_2410 4.24e-33 121.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria 1224|Proteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_29905_3 935837.JAEK01000054_gene1465 1.1e-74 252.0 COG4373@1|root,COG4373@2|Bacteria,1TQNK@1239|Firmicutes,4HDES@91061|Bacilli,1ZBVH@1386|Bacillus 91061|Bacilli S Mu-like prophage FluMu protein gp28 gp17a - - - - - - - - - - - Terminase_6,Terminase_6C k59_327180_2 1618251.A0A0C5I2L8_9CIRC 2.61e-26 106.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_71125_1 1158608.I583_02395 1.04e-44 153.0 COG0671@1|root,COG0671@2|Bacteria,1U3JD@1239|Firmicutes,4IDC2@91061|Bacilli,4B1B8@81852|Enterococcaceae 91061|Bacilli I phosphoesterase, PA-phosphatase related - - - - - - - - - - - - LssY_C k59_272036_1 1618247.A0A0C5IMK7_9CIRC 1.52e-08 60.5 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_2672_4 44060.JODL01000004_gene2457 1.32e-22 94.7 COG5083@1|root,COG5083@2|Bacteria,2IFC7@201174|Actinobacteria 201174|Actinobacteria S phosphatidylinositol transporter activity - - - - - - - - - - - - Acid_phosphat_B k59_420501_1 1465751.W8QRJ5_9VIRU 3.85e-34 131.0 4QAPV@10239|Viruses,4QV7H@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA binding - - - - - - - - - - - - - k59_84004_2 1692242.A0A0K1RKZ2_9CIRC 1.89e-26 112.0 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_420502_1 1380394.JADL01000006_gene5258 2.16e-26 106.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria,2JXPF@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_84011_1 186617.M9M8L2_9VIRU 1.25e-46 164.0 4QFNI@10239|Viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_299373_1 395961.Cyan7425_2093 4.63e-07 56.6 COG0582@1|root,COG0582@2|Bacteria,1FZVF@1117|Cyanobacteria,3KHQD@43988|Cyanothece 1117|Cyanobacteria L Belongs to the 'phage' integrase family - - - ko:K14059 - - - - ko00000 - - - Arm-DNA-bind_2,Phage_int_SAM_5,Phage_integrase k59_97136_2 1406780.U5PW18_9CAUD 1.79e-06 50.8 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_151079_1 242861.Q6UYH2_9CAUD 2.67e-16 84.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_71129_1 1957.JODX01000002_gene4380 3.24e-24 107.0 COG2425@1|root,COG2425@2|Bacteria,2GMHF@201174|Actinobacteria 201174|Actinobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 k59_272150_8 305700.B447_05028 1.23e-08 65.9 COG1783@1|root,COG4626@1|root,COG1783@2|Bacteria,COG4626@2|Bacteria,1PF0Y@1224|Proteobacteria,2W8DT@28216|Betaproteobacteria,2KZM8@206389|Rhodocyclales 206389|Rhodocyclales S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_272150_15 469378.Ccur_02880 2e-21 89.0 2EI48@1|root,33BVK@2|Bacteria,2GZ85@201174|Actinobacteria,4CY1Y@84998|Coriobacteriia 84998|Coriobacteriia - - - - - - - - - - - - - - - k59_272150_17 1177181.T9A_00139 3.78e-08 64.3 COG3378@1|root,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,1RRN5@1236|Gammaproteobacteria,1XQQ9@135619|Oceanospirillales 135619|Oceanospirillales S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N k59_354189_3 1121385.AQXW01000004_gene997 2.13e-22 101.0 COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,1ZWD7@145357|Dermacoccaceae 201174|Actinobacteria L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C k59_316629_2 1151122.AQYD01000006_gene1759 4.33e-06 54.3 COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4FKWD@85023|Microbacteriaceae 201174|Actinobacteria S Fibronectin type 3 domain - - - - - - - - - - - - - k59_180015_1 269482.Bcep1808_4568 8.82e-37 136.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_Tnp_1,HTH_Tnp_IS630 k59_368638_1 469383.Cwoe_4526 4.44e-14 77.0 COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4CPQY@84995|Rubrobacteria 84995|Rubrobacteria L type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_125261_1 591001.Acfer_1951 9.72e-07 56.6 COG5519@1|root,COG5519@2|Bacteria,1TRMV@1239|Firmicutes,4H697@909932|Negativicutes 909932|Negativicutes L Domain of unknown function (DUF927) - - - - - - - - - - - - DUF927 k59_247463_1 1123024.AUII01000012_gene4145 4.94e-05 51.2 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4DXQ3@85010|Pseudonocardiales 201174|Actinobacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_31955_1 1237149.C900_00683 5.54e-06 49.3 COG1396@1|root,COG1396@2|Bacteria,4NVCU@976|Bacteroidetes 2|Bacteria K Helix-turn-helix - - - - - - - - - - - - HTH_3 k59_112114_1 1357275.AVEL02000082_gene597 9.09e-09 62.4 COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1Z76E@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - DUF4124,Peptidase_M23 k59_381427_3 749222.Nitsa_0219 6.83e-14 78.2 2DBI5@1|root,2Z9EN@2|Bacteria,1PMHG@1224|Proteobacteria,42PJZ@68525|delta/epsilon subdivisions,2YN9T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L PDDEXK-like domain of unknown function (DUF3799) - - - - - - - - - - - - DUF3799 k59_381427_4 563192.HMPREF0179_00147 1.33e-52 179.0 28JXH@1|root,2ZA3Z@2|Bacteria,1R8CZ@1224|Proteobacteria,42WKC@68525|delta/epsilon subdivisions,2WUAM@28221|Deltaproteobacteria,2MEKQ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_112265_1 1379270.AUXF01000002_gene1198 1.32e-47 179.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1ZTCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_112265_3 1172188.KB911820_gene2887 7.35e-90 281.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4FFS1@85021|Intrasporangiaceae 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - - - - - - - - - - RecA k59_112265_7 1120936.KB907208_gene1116 4.78e-41 151.0 2FA48@1|root,342D2@2|Bacteria,2H6VX@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_112265_9 1123321.KB905821_gene4246 1.94e-09 62.0 2DM82@1|root,324KK@2|Bacteria,2IP30@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_112265_10 1121468.AUBR01000114_gene3065 1.98e-10 59.3 COG2359@1|root,COG2359@2|Bacteria,1VJPC@1239|Firmicutes,24RHB@186801|Clostridia,42ITM@68295|Thermoanaerobacterales 186801|Clostridia S Stage V sporulation protein S (SpoVS) - - - ko:K06416 - - - - ko00000 - - - SpoVS k59_112265_12 1172188.KB911820_gene2901 1.04e-31 119.0 2915B@1|root,2ZNSM@2|Bacteria,2HE7N@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_220049_1 1440053.JOEI01000012_gene4343 0.00075 47.4 COG4487@1|root,COG5412@1|root,COG4487@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria 201174|Actinobacteria M nuclear chromosome segregation - - - - - - - - - - - - PhageMin_Tail k59_370237_1 701521.PECL_590 1.01e-09 65.5 COG3378@1|root,COG3378@2|Bacteria,1UYRX@1239|Firmicutes,4HC06@91061|Bacilli,3F71D@33958|Lactobacillaceae 91061|Bacilli S DNA primase - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_143720_1 1051675.G0YQH8_9CAUD 1.82e-13 74.3 4QEQT@10239|Viruses,4QYJH@35237|dsDNA viruses no RNA stage,4QQ1B@28883|Caudovirales,4QNPW@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_396948_1 867902.Ornrh_0694 1.68e-16 80.9 COG2003@1|root,COG2003@2|Bacteria,4NFBF@976|Bacteroidetes,1HXJ3@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_60465_1 102129.Lepto7375DRAFT_7192 9.66e-24 107.0 COG0467@1|root,COG1467@1|root,COG0467@2|Bacteria,COG1467@2|Bacteria 2|Bacteria L DNA replication initiation - - - - - - - - - - - - AAA_11,AAA_12,AAA_25,DUF3320,DUF3987,DUF4011 k59_101231_2 6669.EFX69757 3.23e-19 92.0 29NHR@1|root,2RVUJ@2759|Eukaryota,39IP1@33154|Opisthokonta,3C3YZ@33208|Metazoa 6669.EFX69757|- - - - - - - - - - - - - - - - k59_34022_1 31234.CRE19485 1.62e-19 98.2 2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria,40FF9@6231|Nematoda,1KYD3@119089|Chromadorea,414ZH@6236|Rhabditida 33208|Metazoa S DNA polymerase type B, organellar and viral - - - - - - - - - - - - DNA_pol_B_2,Rho_N k59_126805_2 172088.AUGA01000033_gene4641 2.22e-27 108.0 2CXZV@1|root,32T32@2|Bacteria,1N4R9@1224|Proteobacteria,2UM96@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_76851_1 525257.HMPREF0204_11338 1.28e-34 125.0 COG0270@1|root,COG0270@2|Bacteria,4P3NG@976|Bacteroidetes,1I91K@117743|Flavobacteriia 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_359214_2 479437.Elen_0633 1.21e-08 59.3 COG1216@1|root,COG1216@2|Bacteria,2I2EQ@201174|Actinobacteria,4CUME@84998|Coriobacteriia 84998|Coriobacteriia S Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glycos_transf_2 k59_210792_1 45351.EDO26034 1.93e-58 207.0 COG0749@1|root,2RV2U@2759|Eukaryota,3ATJG@33154|Opisthokonta 33154|Opisthokonta L DNA-directed DNA polymerase activity - - - - - - - - - - - - - k59_210792_6 749222.Nitsa_1815 3.82e-32 119.0 2AMKF@1|root,31CGC@2|Bacteria,1Q8QE@1224|Proteobacteria,4327D@68525|delta/epsilon subdivisions,2YSNP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_423873_1 999141.GME_03332 4.61e-10 60.5 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1XJ7F@135619|Oceanospirillales 135619|Oceanospirillales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_168344_1 1121285.AUFK01000002_gene40 4.19e-29 115.0 29D2S@1|root,3000U@2|Bacteria,4PGQF@976|Bacteroidetes,1IM4Y@117743|Flavobacteriia,3ZSNA@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_213026_1 929713.NIASO_00200 1.47e-11 63.9 COG2877@1|root,COG2877@2|Bacteria,4NENN@976|Bacteroidetes,1IQ2W@117747|Sphingobacteriia 976|Bacteroidetes M 2-dehydro-3-deoxyphosphooctonate aldolase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_305723_2 1500386.A0A060AFF3_9CAUD 4.33e-23 94.7 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_36469_1 398512.JQKC01000009_gene437 4.75e-25 108.0 COG3378@1|root,COG4983@1|root,COG3378@2|Bacteria,COG4983@2|Bacteria,1TQP9@1239|Firmicutes,24AY6@186801|Clostridia,3WHX7@541000|Ruminococcaceae 186801|Clostridia S Phage plasmid primase, P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,PriCT_1,Prim-Pol k59_8550_1 1283340.Q6WHK5_BPKVM 8.01e-07 56.2 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_183715_3 553218.CAMRE0001_2407 5.53e-42 147.0 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria 1224|Proteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_361890_1 322855.Q52PN4_9CAUD 1.86e-26 115.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_399152_2 263820.PTO1020 1.89e-07 62.0 COG0494@1|root,COG1573@1|root,arCOG00905@2157|Archaea,arCOG01078@2157|Archaea,2XUVI@28890|Euryarchaeota,242GY@183967|Thermoplasmata 183967|Thermoplasmata L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_170034_1 335283.Neut_1455 7.07e-99 324.0 COG2304@1|root,COG4733@1|root,COG2304@2|Bacteria,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,2VJS7@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_170034_2 1265502.KB905983_gene555 6.03e-14 66.6 2EK40@1|root,33DUE@2|Bacteria,1NJE0@1224|Proteobacteria,2W5HA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_170034_3 1175654.A0A0S0N2N8_9CAUD 2.69e-21 85.1 4QGE9@10239|Viruses,4QVDG@35237|dsDNA viruses no RNA stage,4QS71@28883|Caudovirales,4QMTZ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_36475_1 172088.AUGA01000033_gene4641 1.9e-45 154.0 2CXZV@1|root,32T32@2|Bacteria,1N4R9@1224|Proteobacteria,2UM96@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_62673_4 1123366.TH3_20363 1.33e-16 83.2 COG4675@1|root,COG4675@2|Bacteria,1N0FZ@1224|Proteobacteria,2UDXB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_8559_1 575594.ACOH01000006_gene284 1.71e-20 95.5 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli,3F5VV@33958|Lactobacillaceae 91061|Bacilli L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_322064_1 1120980.JQKH01000028_gene1711 3.53e-15 84.3 COG4643@1|root,COG4643@2|Bacteria,1QTXN@1224|Proteobacteria,2VM6N@28216|Betaproteobacteria,2KQCJ@206351|Neisseriales 206351|Neisseriales S Primase C terminal 2 (PriCT-2) - - - ko:K06919 - - - - ko00000 - - - PriCT_2,Toprim_3 k59_147551_2 1449069.JMLO01000001_gene1579 8.82e-05 47.8 2CICW@1|root,346YY@2|Bacteria,2HIJU@201174|Actinobacteria,4G48K@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_223843_1 1399774.JDWH01000001_gene2878 4.45e-10 68.2 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,3X1U0@547|Enterobacter 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair - - - - - - - - - - - - Helicase_C,SNF2_N k59_24942_1 2045.KR76_15320 1.54e-16 81.6 29WAD@1|root,30HVV@2|Bacteria,2GW9C@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_416021_1 1089551.KE386572_gene4721 1.67e-16 84.3 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,4BRH7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_24944_1 691965.D4P7I3_9CAUD 1.15e-14 75.9 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_24944_3 691965.D4P7I8_9CAUD 2.62e-60 192.0 4QGJH@10239|Viruses,4QZ35@35237|dsDNA viruses no RNA stage,4QRZS@28883|Caudovirales,4QMAA@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_279798_2 391587.KAOT1_16558 1.14e-54 175.0 COG0791@1|root,COG0791@2|Bacteria,4NPFE@976|Bacteroidetes,1I29F@117743|Flavobacteriia 976|Bacteroidetes M CHAP domain - - - - - - - - - - - - CHAP k59_51631_1 1589748.A0A0B4ZZP7_9CAUD 4.46e-12 68.6 4QHNU@10239|Viruses,4QQZH@28883|Caudovirales,4QKRG@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_10742_3 1122931.AUAE01000032_gene2995 9.76e-153 438.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,2FN5D@200643|Bacteroidia,22WEY@171551|Porphyromonadaceae 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_132700_2 743299.Acife_1993 2.23e-16 79.3 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_173147_1 1123248.KB893336_gene2841 1.16e-23 107.0 COG1409@1|root,COG4733@1|root,COG1409@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - Beta_helix,DUF1565,Kelch_4,Laminin_G_3,Malectin,Metallophos,PKD,fn3 k59_39092_1 1197951.I6S6I7_9CAUD 4.42e-12 66.6 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales 28883|Caudovirales S phosphoprotein phosphatase activity - - - - - - - - - - - - - k59_160656_4 1122605.KB893643_gene585 9.35e-06 45.4 2EIK5@1|root,33CBF@2|Bacteria,4NV2P@976|Bacteroidetes,1IU6J@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_333859_2 1692249.A0A0K1RL40_9CIRC 2.33e-40 149.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_430943_1 1692249.A0A0K1RLN8_9CIRC 3.81e-34 129.0 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_229016_3 563192.HMPREF0179_00262 1.81e-16 81.3 2DNTW@1|root,32Z46@2|Bacteria,1N82R@1224|Proteobacteria,431IC@68525|delta/epsilon subdivisions,2WWYT@28221|Deltaproteobacteria,2MDJ5@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_241539_1 1410626.JHXB01000001_gene2172 3.94e-21 94.4 COG2304@1|root,COG2304@2|Bacteria,1TRPP@1239|Firmicutes,249HV@186801|Clostridia,27JM3@186928|unclassified Lachnospiraceae 186801|Clostridia S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA k59_310494_1 484018.BACPLE_00656 1.5e-06 59.7 COG1511@1|root,COG5283@1|root,COG1511@2|Bacteria,COG5283@2|Bacteria,4NIZH@976|Bacteroidetes,2FRQE@200643|Bacteroidia,4AVJV@815|Bacteroidaceae 976|Bacteroidetes D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_391394_2 1158614.I592_02353 1.04e-19 89.0 2DR9Y@1|root,33AUY@2|Bacteria,1VEP1@1239|Firmicutes,4HIWW@91061|Bacilli,4B4BW@81852|Enterococcaceae 91061|Bacilli L NUMOD4 motif - - - - - - - - - - - - HNH_3,NUMOD4 k59_54300_2 1322246.BN4_20101 2.35e-10 66.2 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2WM78@28221|Deltaproteobacteria,2M8CT@213115|Desulfovibrionales 28221|Deltaproteobacteria S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_148556_1 1234888.K0A2J2_9VIRU 1.1e-35 137.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_337444_1 1408422.JHYF01000002_gene2560 8.47e-35 124.0 COG0494@1|root,COG0494@2|Bacteria,1V6ET@1239|Firmicutes,25EBI@186801|Clostridia,36IUD@31979|Clostridiaceae 186801|Clostridia L Belongs to the Nudix hydrolase family mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_242990_1 1123008.KB905697_gene3236 2.45e-07 59.7 COG3210@1|root,COG3210@2|Bacteria,4PPCP@976|Bacteroidetes 976|Bacteroidetes U Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_323849_3 1249627.D779_2284 1.58e-09 54.7 COG3311@1|root,COG3311@2|Bacteria 2|Bacteria K DNA excision - - - ko:K07733 - - - - ko00000,ko03000 - - - Nuc_deoxyrib_tr,Phage_AlpA k59_350919_1 1071679.BG57_03790 3.98e-61 217.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2VNJC@28216|Betaproteobacteria,1K3E8@119060|Burkholderiaceae 28216|Betaproteobacteria S Putative phage tail protein - - - - - - - - - - - - CBM_4_9,DUF1983,Phage-tail_3 k59_323853_1 1367847.JCM7686_2916 6.86e-09 66.2 COG4678@1|root,COG4678@2|Bacteria,1N51M@1224|Proteobacteria,2UC8H@28211|Alphaproteobacteria,2PWTF@265|Paracoccus 28211|Alphaproteobacteria G Muramidase (Phage lambda lysozyme) - - - - - - - - - - - - - k59_55975_8 691965.D4P7L3_9CAUD 1.22e-145 431.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage,4QQ8R@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_379333_1 1618238.A0A0C5IB41_9CIRC 2.11e-12 75.5 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_325520_2 479431.Namu_3149 1.13e-54 192.0 COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4ERCB@85013|Frankiales 201174|Actinobacteria P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_419453_1 1173762.S4TP25_9CAUD 9.63e-81 264.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_365705_2 547042.BACCOPRO_02118 7.34e-14 69.3 2EYVT@1|root,33S2W@2|Bacteria,4P0XD@976|Bacteroidetes,2FR7P@200643|Bacteroidia,4AM24@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - DUF4866 k59_28733_1 1123058.KB894247_gene1358 9.01e-12 70.5 COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,1HYBN@117743|Flavobacteriia 976|Bacteroidetes D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C k59_14942_2 268747.Q58LQ0_BPPRS 4.41e-11 68.6 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QII1@10662|Myoviridae 10662|Myoviridae S N-methyltransferase activity - - - - - - - - - - - - - k59_352532_10 573370.DMR_24830 9.33e-28 111.0 COG0537@1|root,COG1403@1|root,COG0537@2|Bacteria,COG1403@2|Bacteria,1N3EA@1224|Proteobacteria,42WAX@68525|delta/epsilon subdivisions,2WRAN@28221|Deltaproteobacteria,2MD0C@213115|Desulfovibrionales 28221|Deltaproteobacteria FGV Scavenger mRNA decapping enzyme C-term binding - - - - - - - - - - - - HIT k59_352532_17 1173020.Cha6605_1715 1.8e-13 73.2 COG0457@1|root,COG0457@2|Bacteria,1GGS9@1117|Cyanobacteria 1117|Cyanobacteria S Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21,TPR_11 k59_352532_22 1175654.A0A0S0N897_9CAUD 2.6e-129 391.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_352532_25 1175654.A0A0S0N897_9CAUD 2.01e-22 98.2 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_230553_1 1114179.I2FLT8_9CAUD 8.71e-31 135.0 4QAUF@10239|Viruses,4QWIQ@35237|dsDNA viruses no RNA stage,4QUFS@28883|Caudovirales,4QNVK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_325528_1 1380390.JIAT01000016_gene5595 1.51e-06 54.3 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CP7C@84995|Rubrobacteria 84995|Rubrobacteria L DNA polymerase - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_325528_3 1120983.KB894570_gene1486 5.32e-17 87.8 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,1JNSE@119043|Rhodobiaceae 28211|Alphaproteobacteria L Uracil DNA glycosylase superfamily udgA - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_28745_1 388051.AUFE01000035_gene4020 1.65e-12 72.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_312448_1 1054968.G0X4X0_9CAUD 1.22e-10 61.6 4QB07@10239|Viruses,4QVI0@35237|dsDNA viruses no RNA stage,4QQSI@28883|Caudovirales,4QNMQ@10744|Podoviridae 10744|Podoviridae S Protein of unknown function (DUF2493) - - - - - - - - - - - - - k59_298203_1 1122137.AQXF01000002_gene217 2.58e-13 76.6 COG3064@1|root,COG3064@2|Bacteria,1NQ5T@1224|Proteobacteria,2UK7G@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - PTR k59_163286_23 1121296.JONJ01000015_gene134 9.15e-16 89.7 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia,220JC@1506553|Lachnoclostridium 186801|Clostridia M Transglycosylase SLT domain yjbJ - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT k59_163286_27 1340493.JNIF01000004_gene59 2.63e-09 65.5 COG5549@1|root,COG5549@2|Bacteria 2|Bacteria O protein import - - - - - - - - - - - - PG_binding_1,Peptidase_M10 k59_407805_1 1424334.W822_20045 2.19e-76 248.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,3T3DM@506|Alcaligenaceae 28216|Betaproteobacteria S COG4626 Phage terminase-like protein, large subunit - - - - - - - - - - - - Terminase_1 k59_327635_2 525919.Apre_1500 3.65e-100 319.0 COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,22GG1@1570339|Peptoniphilaceae 186801|Clostridia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_327635_4 1408444.JHYC01000015_gene2154 9.81e-12 74.3 COG0438@1|root,COG0438@2|Bacteria,1PGK4@1224|Proteobacteria,1T7RR@1236|Gammaproteobacteria,1JFRF@118969|Legionellales 118969|Legionellales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_2 k59_84444_1 1169152.AXVD01000057_gene1002 2.53e-14 80.5 COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4G5DA@85025|Nocardiaceae 201174|Actinobacteria F Thymidylate synthase - - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_16464_3 211165.AJLN01000060_gene3855 7.27e-36 132.0 COG0030@1|root,COG0030@2|Bacteria 2|Bacteria J rRNA (adenine-N6,N6-)-dimethyltransferase activity ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528,ko:K20444 - - R10716 RC00003,RC03257 ko00000,ko01000,ko01005,ko02000,ko03009 4.D.1.3 GT2,GT4 - CTP_transf_like,Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_12,Methyltransf_23,RrnaAD k59_151295_1 694427.Palpr_1970 1.87e-17 87.4 COG4675@1|root,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein - - - - - - - - - - - - Collar k59_71666_1 1692249.A0A0K1RLN8_9CIRC 9.01e-36 132.0 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_84447_1 314260.PB2503_11314 1.15e-49 187.0 28JTG@1|root,2Z9IR@2|Bacteria,1R0GC@1224|Proteobacteria,2TURR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_299715_2 97139.C824_05158 0.000243 47.4 COG1216@1|root,COG1216@2|Bacteria,1V2M3@1239|Firmicutes,24JI3@186801|Clostridia 186801|Clostridia S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_231541_1 1444309.JAQG01000145_gene2707 2.13e-33 126.0 COG4422@1|root,COG4422@2|Bacteria,1TPP1@1239|Firmicutes,4HAU8@91061|Bacilli,26V16@186822|Paenibacillaceae 91061|Bacilli S Protein of unknown function (DUF5131) - - - - - - - - - - - - DUF5131 k59_367401_1 1128427.KB904821_gene1634 1.1e-09 70.9 COG1404@1|root,COG3121@1|root,COG3291@1|root,COG5549@1|root,COG1404@2|Bacteria,COG3121@2|Bacteria,COG3291@2|Bacteria,COG5549@2|Bacteria,1G2HU@1117|Cyanobacteria,1H9MN@1150|Oscillatoriales 2|Bacteria O PFAM Uncharacterised BCR, COG1649 prtB - 1.1.3.9,3.2.1.4 ko:K01179,ko:K04618,ko:K07346,ko:K12685,ko:K17734 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R01098,R06200,R11307,R11308 RC00194 ko00000,ko00001,ko01000,ko01002,ko02000,ko02035,ko02044,ko03110 1.B.12.5.1,1.B.12.5.3 GH5,GH9 - Autotransporter,F5_F8_type_C,Peptidase_M57,Peptidase_S8 k59_71875_1 1449050.JNLE01000003_gene1208 2.08e-57 195.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,36DSH@31979|Clostridiaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_259536_1 313628.LNTAR_21400 1.98e-10 67.4 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 3.2.1.4,3.2.1.73 ko:K01179,ko:K01216,ko:K21449 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko02000 1.B.40.2 GH5,GH9 - CBM_3,F5_F8_type_C,PKD,fn3 k59_151536_1 1304885.AUEY01000007_gene1352 3.52e-18 87.8 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2WJ0Q@28221|Deltaproteobacteria,2MI3R@213118|Desulfobacterales 28221|Deltaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_299938_5 1234888.K0A2J2_9VIRU 1.84e-95 305.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_138926_2 1527469.A0A076GD96_9CAUD 1.17e-20 90.9 4QAIU@10239|Viruses,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_164830_2 1276221.SDIMI_v3c03770 6.85e-05 53.5 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,3WUEB@544448|Tenericutes 544448|Tenericutes L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII k59_4407_1 1385658.U5KPZ6_9VIRU 1.45e-63 211.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_4415_1 478749.BRYFOR_08521 1.72e-13 75.1 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Peptidase_S78 k59_316849_1 1345697.M493_04595 5.5e-13 73.6 COG1215@1|root,COG1442@1|root,COG1215@2|Bacteria,COG1442@2|Bacteria,1V4HY@1239|Firmicutes,4HHVA@91061|Bacilli 91061|Bacilli M COG0463, glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_218949_1 112098.XP_008607965.1 4.8e-69 233.0 COG1372@1|root,2QRRC@2759|Eukaryota 2759|Eukaryota L reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Ribonuc_red_lgC k59_73850_2 1123057.P872_15805 3.39e-15 80.9 COG2265@1|root,COG2265@2|Bacteria,4PPHS@976|Bacteroidetes,47RXE@768503|Cytophagia 976|Bacteroidetes J Vibrio cholerae RfbT protein - - - - - - - - - - - - Methyltransf_21 k59_233139_1 345201.VF295_IIV3 8.64e-62 216.0 4QFET@10239|Viruses,4QY0D@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_86713_1 1185766.DL1_08470 1.4e-17 88.2 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,2UPJH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_141560_1 1197719.A464_178 1.96e-68 221.0 COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,1RZGQ@1236|Gammaproteobacteria,3ZJEB@590|Salmonella 1236|Gammaproteobacteria S Putative transposase, YhgA-like - - - - - - - - - - - - Transposase_31 k59_125553_1 330214.NIDE3986 1.12e-90 285.0 COG4626@1|root,COG4626@2|Bacteria 2|Bacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_125553_3 1121289.JHVL01000007_gene2757 1.11e-19 85.9 COG3747@1|root,COG3747@2|Bacteria,1V0EC@1239|Firmicutes,24GCB@186801|Clostridia,36I8M@31979|Clostridiaceae 186801|Clostridia L Phage terminase, small subunit - - - - - - - - - - - - Terminase_4 k59_125553_4 1122201.AUAZ01000004_gene3434 7.18e-37 139.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1R7KV@1224|Proteobacteria,1RZ25@1236|Gammaproteobacteria,46BUU@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA methylase VP0394 - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_125553_5 469616.FMAG_00698 2.34e-15 75.5 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,37AID@32066|Fusobacteria 32066|Fusobacteria L DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_32410_1 909613.UO65_0093 5.78e-11 64.3 COG0175@1|root,COG0175@2|Bacteria,2GK5Y@201174|Actinobacteria,4E928@85010|Pseudonocardiales 201174|Actinobacteria EH sulfate reduction - - - - - - - - - - - - - k59_273939_1 331869.BAL199_17218 1.83e-21 99.0 28IAN@1|root,2Z8D8@2|Bacteria,1NJD6@1224|Proteobacteria,2U7YP@28211|Alphaproteobacteria,4BR2J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4055) - - - - - - - - - - - - DUF4055 k59_395572_2 1692257.A0A0K1RL39_9CIRC 1.69e-77 246.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_317094_4 1120933.ATUY01000002_gene83 1.64e-64 220.0 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,4D420@85005|Actinomycetales 201174|Actinobacteria KL SNF2 family N-terminal domain protein - - - - - - - - - - - - SNF2_N k59_317094_5 1449126.JQKL01000051_gene3182 2.1e-09 57.8 2E38J@1|root,32Y88@2|Bacteria,1VAXK@1239|Firmicutes,24N7K@186801|Clostridia 186801|Clostridia S VRR-NUC domain protein - - - - - - - - - - - - VRR_NUC k59_317094_6 240302.BN982_00207 2.11e-85 288.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli 91061|Bacilli L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_317094_8 1286171.EAL2_808p01520 4.47e-19 95.9 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,25V8B@186806|Eubacteriaceae 186801|Clostridia L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_317094_11 483219.LILAB_25320 6.62e-13 66.2 2BZTS@1|root,33131@2|Bacteria,1NBBP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_329208_2 691965.D4P7L3_9CAUD 1.28e-64 215.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage,4QQ8R@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_99616_2 449673.BACSTE_02196 3.18e-56 195.0 COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FQKQ@200643|Bacteroidia,4AQK8@815|Bacteroidaceae 976|Bacteroidetes K ParB-like nuclease domain - - - - - - - - - - - - DUF4417,ParBc k59_144479_1 237727.NAP1_12148 6.39e-06 54.7 2DSHN@1|root,33G5Q@2|Bacteria,1NGM3@1224|Proteobacteria,2UK0H@28211|Alphaproteobacteria,2K4KJ@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_345805_1 349161.Dred_1193 1.74e-84 263.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,24CGS@186801|Clostridia 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_345805_2 1504822.CCNO01000015_gene594 1.68e-124 386.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_370730_1 420324.KI911970_gene1439 1.2e-27 119.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase family A - - - - - - - - - - - - DNA_pol_A k59_127290_2 697282.Mettu_0947 1.36e-95 290.0 COG0175@1|root,COG0175@2|Bacteria,1PZ96@1224|Proteobacteria,1SBUC@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_359520_1 1109712.G9FHH6_9CAUD 7.25e-47 169.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0042802,GO:0044423,GO:0046806,GO:0098015,GO:0098026 - - - - - - - - - - - k59_114200_1 926556.Echvi_2948 5.28e-67 226.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,47JB5@768503|Cytophagia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_114200_2 522373.Smlt1885 9.77e-13 70.1 COG0817@1|root,COG0817@2|Bacteria,1RCYK@1224|Proteobacteria,1S3HF@1236|Gammaproteobacteria,1X622@135614|Xanthomonadales 135614|Xanthomonadales L genomic island protein Bartonella henselae str. Houston-1 gi 49238285 emb CAF27499.1 and to - - - - - - - - - - - - - k59_195283_3 1220582.RRU01S_19_00280 2.7e-06 51.2 COG3179@1|root,COG3179@2|Bacteria,1NDDE@1224|Proteobacteria,2UIIC@28211|Alphaproteobacteria,4BMHQ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Chitinase class I - - - - - - - - - - - - Glyco_hydro_19 k59_211027_1 1327036.R4JQQ9_9CAUD 7.61e-35 125.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_397594_1 497965.Cyan7822_2928 2.7e-05 52.4 COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,1G2YS@1117|Cyanobacteria,3KGC3@43988|Cyanothece 1117|Cyanobacteria M PFAM O-antigen polymerase - - - - - - - - - - - - Wzy_C k59_346096_1 1449351.RISW2_21770 1.09e-20 102.0 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - PhageMin_Tail,TMP_2,Tape_meas_lam_C k59_213738_1 1122137.AQXF01000005_gene1300 0.000109 50.4 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,2U6AR@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_384656_1 521000.PROVRETT_07464 3.37e-24 108.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,3Z7NF@586|Providencia 1236|Gammaproteobacteria KL Helicase C-terminal domain protein yejH GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042221,GO:0042493,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051301,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII k59_129739_1 1038859.AXAU01000029_gene71 2.57e-11 67.4 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,3JVM3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_91428_1 1465751.W8QF03_9VIRU 1.54e-124 389.0 4QB98@10239|Viruses,4QWE3@35237|dsDNA viruses no RNA stage 10239|Viruses S Glycosyl transferase family 90 - - - - - - - - - - - - - k59_278047_1 999419.HMPREF1077_01869 8.34e-32 125.0 COG3378@1|root,COG3378@2|Bacteria,4NE1A@976|Bacteroidetes,2FPTD@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_9101_1 397291.C804_05736 0.000116 46.2 COG1846@1|root,COG1846@2|Bacteria,1VAGH@1239|Firmicutes,24N7S@186801|Clostridia 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_9101_4 1280944.HY17_04540 4.27e-15 76.6 COG0270@1|root,COG0270@2|Bacteria,1R5MR@1224|Proteobacteria,2U53Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_80811_1 215803.DB30_4622 1.07e-26 107.0 COG0338@1|root,COG0338@2|Bacteria,1Q9YJ@1224|Proteobacteria,438CP@68525|delta/epsilon subdivisions,2X1WK@28221|Deltaproteobacteria,2YWK0@29|Myxococcales 28221|Deltaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase - - - - - - - - - - - - MethyltransfD12 k59_251981_1 570967.JMLV01000003_gene2335 3.05e-34 132.0 COG0582@1|root,COG0582@2|Bacteria,1N45B@1224|Proteobacteria,2UAW5@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_362646_1 1197951.I6R9K8_9CAUD 2.5e-56 187.0 4QFIC@10239|Viruses,4QXG2@35237|dsDNA viruses no RNA stage,4QTVA@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_116554_1 233412.HD_1569 5.09e-08 62.0 COG5281@1|root,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1S3MM@1236|Gammaproteobacteria,1Y73U@135625|Pasteurellales 135625|Pasteurellales S tail length tape measure protein - - - - - - - - - - - - - k59_129930_1 1210884.HG799467_gene13130 1.81e-99 299.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_49842_1 596153.Alide_1431 2.38e-97 299.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_116561_2 1692252.A0A0K1RL35_9CIRC 1.11e-14 72.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_223994_2 1280671.AUJH01000012_gene3151 2.1e-09 63.9 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,4C0IN@830|Butyrivibrio 186801|Clostridia S Phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_268794_1 1506994.JNLQ01000002_gene1583 0.000127 48.9 COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,25B03@186801|Clostridia,4BXGZ@830|Butyrivibrio 186801|Clostridia L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_374440_1 553217.ENHAE0001_2185 2.37e-67 227.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Type III restriction protein res subunit yejH GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042221,GO:0042493,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051301,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII k59_238100_1 1380394.JADL01000008_gene3768 6.43e-60 207.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria,2U5NE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - - k59_65238_2 1123508.JH636461_gene291 1.92e-29 124.0 COG0497@1|root,COG0497@2|Bacteria 2|Bacteria L DNA recombination tcdA2 - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - AAA_13,Peptidase_S46,Tubulin_2,VRP1 k59_268817_1 1502724.FF80_02999 4.19e-28 121.0 28JTG@1|root,2Z7PY@2|Bacteria,1QVNY@1224|Proteobacteria,2U7ED@28211|Alphaproteobacteria,3N6VP@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_106195_1 1486472.A0A068F8L3_9CAUD 6e-93 288.0 4QFZZ@10239|Viruses,4QZDM@35237|dsDNA viruses no RNA stage,4QTM7@28883|Caudovirales,4QN1U@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_416472_2 1458862.A0A088C534_9CAUD 6.83e-75 253.0 4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses no RNA stage,4QR8A@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_52246_1 1399774.JDWH01000036_gene4049 1.55e-09 68.2 COG0840@1|root,COG4733@1|root,COG0840@2|Bacteria,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,1S1E5@1236|Gammaproteobacteria,3X48S@547|Enterobacter 1236|Gammaproteobacteria NT Putative phage tail protein - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF1983,Phage-tail_3 k59_173469_2 909663.KI867150_gene2299 1.85e-15 77.0 2EKDN@1|root,33E3Y@2|Bacteria,1NH30@1224|Proteobacteria,4329M@68525|delta/epsilon subdivisions,2WXJH@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_118492_2 742733.HMPREF9469_05079 4.39e-15 75.5 2A0KC@1|root,30NQJ@2|Bacteria,1V3K4@1239|Firmicutes,24HYK@186801|Clostridia,222N6@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_416492_1 1131814.JAFO01000001_gene2533 3.17e-83 276.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3EYWG@335928|Xanthobacteraceae 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_133129_3 406327.Mevan_0570 2.63e-15 72.4 arCOG06669@1|root,arCOG06669@2157|Archaea,2XV2H@28890|Euryarchaeota,23RJC@183939|Methanococci 183939|Methanococci - - - - - - - - - - - - - - - k59_374474_1 411154.GFO_2469 1.56e-43 151.0 COG0863@1|root,COG0863@2|Bacteria,4NQQ1@976|Bacteroidetes,1I957@117743|Flavobacteriia 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_175534_6 287.DR97_5374 1.87e-99 299.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,1RZZ3@1236|Gammaproteobacteria,1YKA6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L RecT family recT GO:0000724,GO:0000725,GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0018130,GO:0019438,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043150,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_310547_1 105559.Nwat_1521 2.3e-153 445.0 COG0675@1|root,COG0675@2|Bacteria,1MUU0@1224|Proteobacteria,1RS1J@1236|Gammaproteobacteria,1X038@135613|Chromatiales 135613|Chromatiales L Probable transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_377930_1 742767.HMPREF9456_03404 5.91e-65 206.0 COG0270@1|root,COG0270@2|Bacteria,4P351@976|Bacteroidetes 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_67773_2 351746.Pput_4099 0.000105 48.5 2EDKQ@1|root,337GJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_67773_3 351746.Pput_4099 9.1e-06 50.1 2EDKQ@1|root,337GJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_54368_1 591157.SSLG_03641 2.48e-06 58.9 COG3953@1|root,COG5280@1|root,COG5283@1|root,COG5412@1|root,COG3953@2|Bacteria,COG5280@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria 201174|Actinobacteria KT Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail,SLT k59_135083_4 574087.Acear_0223 2.33e-25 102.0 COG0615@1|root,COG0615@2|Bacteria,1UJSU@1239|Firmicutes,24MH0@186801|Clostridia,3WAS5@53433|Halanaerobiales 186801|Clostridia H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - - - - - - - - - - CTP_transf_like k59_135083_10 398525.KB900701_gene5077 3.16e-05 54.7 COG4409@1|root,COG4409@2|Bacteria,1N9RS@1224|Proteobacteria,2UJ6J@28211|Alphaproteobacteria 28211|Alphaproteobacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - - k59_323882_1 1096546.WYO_0193 2.14e-34 128.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria 1224|Proteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_391627_3 1121441.AUCX01000020_gene668 6.29e-15 82.0 COG0110@1|root,COG3562@1|root,COG0110@2|Bacteria,COG3562@2|Bacteria,1N6SQ@1224|Proteobacteria,42VI7@68525|delta/epsilon subdivisions,2WR74@28221|Deltaproteobacteria,2MAVN@213115|Desulfovibrionales 28221|Deltaproteobacteria Q transferase hexapeptide repeat - - 2.3.1.18 ko:K00633,ko:K03818 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 k59_310872_1 1229485.AMYV01000009_gene887 4.23e-06 49.7 2CAXP@1|root,31HHM@2|Bacteria,1N2ZI@1224|Proteobacteria,1SB8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Antitermination protein Q Q - - - - - - - - - - - Phage_antitermQ k59_177117_5 1235661.K0IGL1_9CAUD 8.69e-62 218.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNI0@10744|Podoviridae 10744|Podoviridae S viral capsid - GO:0003674,GO:0005488,GO:0005515,GO:0042802 - - - - - - - - - - - k59_15436_1 913865.DOT_1568 6.53e-28 114.0 28MC2@1|root,2ZAQD@2|Bacteria,1VSEU@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_419816_1 1469607.KK073765_gene6564 5.26e-08 60.1 COG0476@1|root,COG0476@2|Bacteria,1G5NY@1117|Cyanobacteria,1HRN2@1161|Nostocales 1117|Cyanobacteria H ThiF family - - - - - - - - - - - - ThiF k59_352998_4 1094558.ME5_01681 2e-34 127.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2U7X4@28211|Alphaproteobacteria,48TF4@772|Bartonellaceae 28211|Alphaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_96579_1 36809.MAB_1797 1.8e-48 167.0 2BK4W@1|root,32EII@2|Bacteria,2GX0H@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_245039_2 1033802.SSPSH_000063 3.81e-14 68.2 2ENXC@1|root,33GIB@2|Bacteria,1NIEJ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_56492_1 1609634.A0A0C5AFT2_9VIRU 3.03e-74 234.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_163709_1 1327981.S0A2G1_9CAUD 3.22e-55 189.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_421062_6 1229780.BN381_10225 7.32e-08 58.9 COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria 201174|Actinobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_16977_1 1379692.S5SXY7_9CIRC 1.79e-08 62.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_286626_2 1122243.KB903778_gene913 4.07e-18 99.4 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1NFKU@1224|Proteobacteria,1RP2D@1236|Gammaproteobacteria,3NK8W@468|Moraxellaceae 1236|Gammaproteobacteria D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_380750_4 497964.CfE428DRAFT_1306 4.53e-16 75.5 COG2852@1|root,COG2852@2|Bacteria,46WC5@74201|Verrucomicrobia 74201|Verrucomicrobia S Protein conserved in bacteria - - - - - - - - - - - - - k59_328388_1 1234664.AMRO01000024_gene1817 8.92e-11 69.3 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,4ITVP@91061|Bacilli,1WE4X@129337|Geobacillus 91061|Bacilli S Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_380752_1 1234888.K0A2J2_9VIRU 4.1e-39 146.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_139841_1 497964.CfE428DRAFT_0770 7.81e-30 114.0 2DSBU@1|root,33FEQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_218575_1 1236000.L0AQQ0_9CAUD 1.48e-16 79.3 4QGM3@10239|Viruses,4QYG4@35237|dsDNA viruses no RNA stage,4QPTC@28883|Caudovirales,4QJW3@10662|Myoviridae 10662|Myoviridae S Pfam:Terminase_6C - - - - - - - - - - - - - k59_218575_2 491205.JARQ01000010_gene3602 4.1e-05 43.1 2EIK5@1|root,33CBF@2|Bacteria,4NV2P@976|Bacteroidetes,1IAF5@117743|Flavobacteriia,3ZSQ6@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_218575_3 1264700.L0MZ02_9CAUD 1.14e-13 71.2 4QC8M@10239|Viruses,4QWMX@35237|dsDNA viruses no RNA stage,4QQU8@28883|Caudovirales,4QIAN@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF1073) - - - - - - - - - - - - - k59_272951_7 1120936.KB907208_gene1069 5.63e-68 228.0 COG3567@1|root,COG3567@2|Bacteria,2H48H@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_31167_2 649747.HMPREF0083_01683 5.93e-06 49.3 COG4373@1|root,COG4373@2|Bacteria,1TQNK@1239|Firmicutes,4HDES@91061|Bacilli,26WPR@186822|Paenibacillaceae 91061|Bacilli S Mu-like prophage FluMu protein gp28 gp17a - - - - - - - - - - - Terminase_6,Terminase_6C k59_246728_1 1335760.ASTG01000040_gene3614 8.24e-37 134.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_302705_1 114615.BRADO3646 2.43e-08 63.2 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,3JW1G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_288711_1 1692253.A0A0K1RLM4_9CIRC 5.95e-17 81.3 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_33676_2 366602.Caul_0362 1.76e-33 121.0 2DMHT@1|root,32RN3@2|Bacteria,1N0KK@1224|Proteobacteria,2UCFK@28211|Alphaproteobacteria,2KJ8K@204458|Caulobacterales 204458|Caulobacterales J PEGA domain - - - - - - - - - - - - PEGA k59_19631_3 1094561.MEI_00502 7.23e-06 52.8 COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,2U7NK@28211|Alphaproteobacteria,48TFU@772|Bartonellaceae 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_344828_1 411460.RUMTOR_01356 1.79e-99 320.0 28JED@1|root,2Z98K@2|Bacteria,1TW1U@1239|Firmicutes,24CFD@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - GerE k59_382305_1 1486472.A0A068F3I8_9CAUD 4.97e-105 326.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_358363_1 1316444.K645_326 4.46e-42 153.0 COG0162@1|root,COG0162@2|Bacteria,4NF19@976|Bacteroidetes,1HY1I@117743|Flavobacteriia,3IV7M@39782|Blattabacteriaceae 976|Bacteroidetes J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_154542_3 391587.KAOT1_19172 4.12e-05 51.6 COG1961@1|root,COG1961@2|Bacteria,4NFJA@976|Bacteroidetes,1HZSJ@117743|Flavobacteriia 976|Bacteroidetes L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase k59_194448_2 883080.HMPREF9697_01794 8.6e-05 47.0 COG5434@1|root,COG5434@2|Bacteria,1QW8B@1224|Proteobacteria,2TSD5@28211|Alphaproteobacteria,3JQXR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_181420_2 1410619.SRDD_27170 2.69e-10 62.8 COG1396@1|root,COG2932@1|root,COG1396@2|Bacteria,COG2932@2|Bacteria,1PIRG@1224|Proteobacteria,1S499@1236|Gammaproteobacteria,405PW@613|Serratia 1236|Gammaproteobacteria K Peptidase S24-like prtR3 - - - - - - - - - - - HTH_3,Peptidase_S24 k59_263171_1 1464048.JNZS01000018_gene2111 6.53e-05 52.0 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Beta_helix,CBM_6,F5_F8_type_C,Pectate_lyase_3 k59_101207_1 240302.BN982_04115 4.24e-14 69.3 COG5437@1|root,COG5437@2|Bacteria,1VFXV@1239|Firmicutes,4HNWZ@91061|Bacilli 91061|Bacilli S Phage tail tube protein - - - - - - - - - - - - Phage_tail_2 k59_113733_1 1051675.G0YQH9_9CAUD 2.71e-10 58.5 4QE9C@10239|Viruses,4QYNI@35237|dsDNA viruses no RNA stage,4QRG0@28883|Caudovirales,4QP0M@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_113733_2 1283071.R9R4C3_9CAUD 6.45e-08 56.6 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_196755_2 391038.Bphy_1861 1.27e-40 146.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2VUEJ@28216|Betaproteobacteria,1K8Z8@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_277335_3 537013.CLOSTMETH_02691 4.76e-15 72.8 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24UEE@186801|Clostridia 186801|Clostridia K helix-turn-helix - - - - - - - - - - - - HTH_3 k59_256260_2 632292.Calhy_0414 1.15e-05 55.8 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42FJ3@68295|Thermoanaerobacterales 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_256260_3 596315.HMPREF0634_0377 1.2e-117 395.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,25QW9@186804|Peptostreptococcaceae 186801|Clostridia L DNA polymerase dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_256260_4 67267.JNXT01000017_gene7190 3.63e-33 132.0 COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis - - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_403784_1 1121267.JHZL01000005_gene1685 6.66e-80 248.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42NPS@68525|delta/epsilon subdivisions,2YNCM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Cytosine-specific methyltransferase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_188717_1 1157637.KB892101_gene2444 7.21e-05 47.4 COG0739@1|root,COG0739@2|Bacteria,2GU2Q@201174|Actinobacteria 201174|Actinobacteria M peptidase - - - - - - - - - - - - Peptidase_M23 k59_282997_2 742159.HMPREF0004_2565 1.13e-49 171.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VMBN@28216|Betaproteobacteria,3T29U@506|Alcaligenaceae 1224|Proteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_282997_5 1033810.HLPCO_001832 9.53e-09 56.6 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_387813_2 1172188.KB911820_gene2847 5.46e-36 135.0 COG3567@1|root,COG3567@2|Bacteria,2H48H@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_226746_1 309799.DICTH_0721 3e-59 205.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_376837_1 345201.VF350_IIV3 7.72e-94 281.0 4QG1P@10239|Viruses,4QYYI@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_387822_2 767817.Desgi_3096 2.64e-47 165.0 COG4422@1|root,COG4422@2|Bacteria,1TPRY@1239|Firmicutes,247VT@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score - - - - - - - - - - - - DUF5131 k59_270749_3 5722.XP_001313759.1 9.61e-06 57.0 2D06C@1|root,2SCZW@2759|Eukaryota 5722.XP_001313759.1|- S Phage tail repeat like - - - - - - - - - - - - - k59_149457_1 742733.HMPREF9469_05062 5.05e-60 201.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia,222GT@1506553|Lachnoclostridium 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_284179_2 1340713.S5Z352_9CAUD 8.78e-18 81.3 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_14377_1 1416011.V9QJ30_9CAUD 5.86e-16 78.2 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_953_1 1788447.A0A190WHJ9_9CIRC 1.85e-59 191.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_365335_1 172088.AUGA01000071_gene7569 6.41e-39 149.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_95482_1 76869.PputGB1_1389 4.56e-31 125.0 COG0438@1|root,COG2227@1|root,COG4641@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria,COG4641@2|Bacteria,1R8HV@1224|Proteobacteria,1S3XH@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Glycosyl transferases group 1 - - - - - - - - - - - - DUF3880,Glyco_trans_1_2 k59_55535_1 375286.mma_0323 1.13e-07 63.9 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,4724B@75682|Oxalobacteraceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_55535_2 1254432.SCE1572_45505 7.74e-07 55.5 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2YTW8@29|Myxococcales 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_68745_2 756499.Desde_0480 5.62e-05 50.8 COG0188@1|root,COG0188@2|Bacteria,1VRIC@1239|Firmicutes,24P42@186801|Clostridia,2642P@186807|Peptococcaceae 186801|Clostridia L Protein of unknown function (DUF3102) - - - - - - - - - - - - DUF3102 k59_41631_6 1423144.Gal_02288 2.09e-35 132.0 COG1403@1|root,COG1403@2|Bacteria,1N0FM@1224|Proteobacteria,2TWQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ERF superfamily - - - - - - - - - - - - ERF k59_311928_1 940282.CADQ01000042_gene690 3.17e-87 278.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,2JYGZ@204441|Rhodospirillales 204441|Rhodospirillales S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_379023_1 1457393.AZ09_08095 4.39e-09 64.7 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TTEX@28211|Alphaproteobacteria,2JVUB@204441|Rhodospirillales 204441|Rhodospirillales S Terminase - - - - - - - - - - - - Terminase_1 k59_177755_1 1051675.G0YQH7_9CAUD 3.9e-21 99.0 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_205418_1 626418.bglu_1g23810 9.31e-11 67.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - 3.1.1.32,3.1.1.4 ko:K01058,ko:K07502 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - DUF2911,PEGA,T5orf172 k59_16052_2 1158318.ATXC01000001_gene1188 1.36e-09 58.9 COG0629@1|root,COG0629@2|Bacteria,2G55E@200783|Aquificae 200783|Aquificae L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_43021_2 502025.Hoch_3503 1.25e-12 65.1 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,437K2@68525|delta/epsilon subdivisions,2WW0X@28221|Deltaproteobacteria,2YVI7@29|Myxococcales 28221|Deltaproteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_151009_1 865938.Weevi_0254 6.02e-34 133.0 COG1783@1|root,COG1783@2|Bacteria,4P9P0@976|Bacteroidetes,1I733@117743|Flavobacteriia 976|Bacteroidetes S Phage terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3 k59_299270_1 395494.Galf_2032 2.26e-08 59.3 COG3355@1|root,COG3355@2|Bacteria,1N3ME@1224|Proteobacteria,2VTXQ@28216|Betaproteobacteria 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - - k59_420414_1 1122939.ATUD01000012_gene3124 6.28e-27 118.0 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,2HNJK@201174|Actinobacteria,4CPKZ@84995|Rubrobacteria 84995|Rubrobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,TPR_16 k59_2584_5 1158150.KB906242_gene217 8.48e-20 87.8 COG1694@1|root,COG1694@2|Bacteria,1NBT1@1224|Proteobacteria 1224|Proteobacteria S protein of Mannheimia haemolytica PHL213 UniRef RepID A7JSI2_PASHA - - - - - - - - - - - - MazG k59_138320_1 323261.Noc_0053 2.08e-97 303.0 COG0305@1|root,COG0305@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria,1X1UJ@135613|Chromatiales 135613|Chromatiales L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - DnaB_C k59_30029_1 471857.Svir_14950 0.000456 46.2 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4E1BR@85010|Pseudonocardiales 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 - R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_97224_1 1788444.A0A190WHB9_9CIRC 1.65e-60 196.0 4QASI@10239|Viruses,4QUM7@29258|ssDNA viruses 10239|Viruses L Geminivirus coat protein/nuclear export factor BR1 family - GO:0005575,GO:0018995,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0042025,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_393698_2 1492738.FEM21_31020 2.5e-07 55.8 COG1752@1|root,COG1752@2|Bacteria,4NERH@976|Bacteroidetes,1HZ38@117743|Flavobacteriia,2NV4H@237|Flavobacterium 976|Bacteroidetes S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_217933_2 224911.27351823 4.02e-11 67.8 COG0823@1|root,COG2911@1|root,COG2931@1|root,COG3209@1|root,COG0823@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3JUXC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria MQ COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_327267_2 1340534.S4X3B5_9CAUD 6.83e-06 57.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_354085_1 1207076.ALAT01000194_gene1117 8.06e-14 70.1 2DSMC@1|root,33GP4@2|Bacteria,1NCDH@1224|Proteobacteria,1T10M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4326) - - - - - - - - - - - - DUF4326 k59_316312_1 205918.Psyr_2827 1.02e-45 159.0 COG0175@1|root,COG0175@2|Bacteria,1PZ96@1224|Proteobacteria,1SBUC@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_409120_1 1038860.AXAP01000067_gene8427 4.42e-25 106.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_165981_2 460265.Mnod_6864 3.79e-15 80.5 COG0500@1|root,COG2226@2|Bacteria,1QYPC@1224|Proteobacteria,2TXUB@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_165981_4 1298920.KI911353_gene2689 7.68e-18 84.7 COG0202@1|root,COG0202@2|Bacteria 2|Bacteria K RNA polymerase activity rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K02909,ko:K03040,ko:K03046 ko00230,ko00240,ko01100,ko03010,ko03020,map00230,map00240,map01100,map03010,map03020 M00178,M00183 R00435,R00441,R00442,R00443 RC02795 br01610,br01611,ko00000,ko00001,ko00002,ko01000,ko03011,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_395220_2 575540.Isop_2442 2.76e-09 58.2 COG4570@1|root,COG4570@2|Bacteria 2|Bacteria L crossover junction endodeoxyribonuclease activity rusA GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008821,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.1.22.4 ko:K01160 - - - - ko00000,ko01000,ko03400 - - - RusA k59_316567_3 1506572.A0A097ZPG0_9CIRC 7.75e-38 144.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_261083_1 172088.AUGA01000033_gene4641 1.15e-37 135.0 2CXZV@1|root,32T32@2|Bacteria,1N4R9@1224|Proteobacteria,2UM96@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_218824_1 631454.N177_3925 7.69e-18 85.9 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,1JNNI@119043|Rhodobiaceae 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_232784_1 1692250.A0A0K1RLR1_9CIRC 2.3e-72 229.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_232784_3 1475143.W8SNN0_9CIRC 2.82e-15 74.3 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_261088_2 449447.MAE_33580 9.19e-105 319.0 COG0675@1|root,COG0675@2|Bacteria,1G3XF@1117|Cyanobacteria 1117|Cyanobacteria L Transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_179980_1 485917.Phep_0926 6.67e-36 130.0 COG3409@1|root,COG3409@2|Bacteria,4NSG3@976|Bacteroidetes,1IYAD@117747|Sphingobacteriia 976|Bacteroidetes M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - CHAP k59_287274_1 93220.LV28_00030 2.29e-43 150.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2VUEJ@28216|Betaproteobacteria,1K8Z8@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_409345_1 1986029.Q9MBM3_9VIRU 6.73e-20 94.7 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_18026_1 375286.mma_2228 5.52e-35 125.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VW90@28216|Betaproteobacteria 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_273636_1 1273707.L7TH85_9CAUD 2.01e-42 147.0 4QEMB@10239|Viruses,4QVSG@35237|dsDNA viruses no RNA stage,4QQ55@28883|Caudovirales,4QP45@10744|Podoviridae 10744|Podoviridae S Bacteriophage Lambda NinG protein - - - - - - - - - - - - - k59_86328_1 1123237.Salmuc_02459 0.000512 40.8 2DQ5P@1|root,334V2@2|Bacteria,1NETA@1224|Proteobacteria,2UIGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S gpW - - - - - - - - - - - - gpW k59_140911_1 134676.ACPL_1489 9.91e-58 192.0 COG3440@1|root,COG3440@2|Bacteria,2HKDU@201174|Actinobacteria 201174|Actinobacteria V HNH endonuclease - - - ko:K07454 - - - - ko00000 - - - HNH,HNH_2,SAD_SRA k59_411237_2 457398.HMPREF0326_01533 1.64e-77 258.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,42VU9@68525|delta/epsilon subdivisions,2WRKB@28221|Deltaproteobacteria,2M93F@213115|Desulfovibrionales 28221|Deltaproteobacteria S phage portal protein, lambda - - - - - - - - - - - - Phage_portal_2 k59_370064_1 1269813.ATUL01000006_gene1802 5.2e-39 142.0 COG5449@1|root,COG5449@2|Bacteria,1MXK2@1224|Proteobacteria 1224|Proteobacteria S Conserved Protein - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_370064_2 388399.SSE37_08038 1.19e-31 120.0 COG5448@1|root,COG5448@2|Bacteria,1MXM8@1224|Proteobacteria,2TTJ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glycoside hydrolase family 24 - - - - - - - - - - - - DUF2460 k59_302899_1 196627.cg2001 4.09e-28 119.0 COG1996@1|root,COG1996@2|Bacteria,2I5D0@201174|Actinobacteria 201174|Actinobacteria K Probable Zinc-ribbon domain - - - - - - - - - - - - DUF4379 k59_411245_1 948071.S4S2D9_9CAUD 1.17e-104 324.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_46447_1 44088.Q6VZJ4_CNPV 1.1e-14 75.1 4QB1C@10239|Viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_318654_1 388051.AUFE01000035_gene4020 3.38e-62 204.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_126651_2 717785.HYPMC_1228 3.99e-41 140.0 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_275018_1 1122201.AUAZ01000017_gene2950 2.22e-47 164.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria,46BED@72275|Alteromonadaceae 1236|Gammaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_345076_1 1121289.JHVL01000007_gene2755 2.89e-13 75.9 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,36H1A@31979|Clostridiaceae 186801|Clostridia S Phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_396813_5 1168478.I6S6M4_9CAUD 1.2e-150 431.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QN7D@10699|Siphoviridae 10699|Siphoviridae S ATPase activity - - - - - - - - - - - - - k59_358643_1 1609634.A0A0C5AFV4_9VIRU 5.38e-22 95.1 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_358643_2 105154.Q9MBU3_9VIRU 3.03e-17 84.0 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_154698_6 907931.AEIZ01000007_gene672 8.63e-12 68.2 COG3774@1|root,COG3774@2|Bacteria,1V3YG@1239|Firmicutes,4HXBN@91061|Bacilli,4AYJW@81850|Leuconostocaceae 91061|Bacilli M Glycosyltransferase sugar-binding region containing DXD motif - - - - - - - - - - - - Gly_transf_sug k59_33846_2 1231391.AMZF01000040_gene461 8.06e-21 95.1 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,3T265@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_33846_3 888060.HMPREF9081_2438 9.19e-28 114.0 COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,4H20C@909932|Negativicutes 909932|Negativicutes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_33846_4 1322246.BN4_10554 0.00026 44.3 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2M90H@213115|Desulfovibrionales 28221|Deltaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_88528_1 204669.Acid345_3174 1.71e-29 120.0 COG5511@1|root,COG5511@2|Bacteria,3Y69V@57723|Acidobacteria,2JKEE@204432|Acidobacteriia 204432|Acidobacteriia S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_101322_1 294631.Q5ZGB2_9CAUD 7.01e-66 209.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_60579_1 665956.HMPREF1032_00686 1.31e-23 113.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,3WN92@541000|Ruminococcaceae 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_345352_1 1211640.K4JRQ9_9CAUD 5.58e-43 159.0 4QEN8@10239|Viruses,4QXAY@35237|dsDNA viruses no RNA stage,4QRR4@28883|Caudovirales 28883|Caudovirales S TROVE domain - - - - - - - - - - - - - k59_128617_1 1304275.C41B8_05408 4.28e-97 291.0 2DVPY@1|root,33WQ8@2|Bacteria,1N9VQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_212287_1 686340.Metal_2594 7.03e-65 203.0 2C5J1@1|root,3067M@2|Bacteria,1N4SF@1224|Proteobacteria,1SFV6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_102815_1 243365.CV_3507 4.54e-08 53.9 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KQ1A@206351|Neisseriales 206351|Neisseriales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_78867_1 1234888.K0A2J2_9VIRU 7.37e-46 164.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_371599_5 1165094.RINTHH_3920 5.48e-36 134.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_115278_1 1204537.J3SMN7_9CAUD 3.35e-25 113.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_305022_1 1692249.A0A0K1RLN8_9CIRC 4.54e-20 91.3 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_221231_1 56780.SYN_02235 1.03e-29 119.0 COG0305@1|root,COG0305@2|Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication dnaG - 3.6.4.12 ko:K02314,ko:K02316 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_25,AAA_5,DUF2075,DnaB,DnaB_C,DnaB_bind,DnaG_DnaB_bind,Prim-Pol,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_251003_1 1449080.JQMV01000003_gene1049 2.52e-05 53.1 COG1216@1|root,COG1216@2|Bacteria,1WIU0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_103149_3 1166130.H650_06845 3.26e-40 149.0 COG3740@1|root,COG4653@1|root,COG3740@2|Bacteria,COG4653@2|Bacteria,1Q3BS@1224|Proteobacteria,1S17W@1236|Gammaproteobacteria,3X2X6@547|Enterobacter 1236|Gammaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_347473_1 398578.Daci_3408 8.12e-12 64.7 COG0847@1|root,COG0847@2|Bacteria,1R9YS@1224|Proteobacteria,2VZ0G@28216|Betaproteobacteria 28216|Betaproteobacteria L 3' exoribonuclease, RNase T-like - - - - - - - - - - - - DUF5051 k59_265414_1 1220534.B655_0361 9.81e-06 53.1 arCOG07611@1|root,arCOG07611@2157|Archaea,2Y6AM@28890|Euryarchaeota,23PGQ@183925|Methanobacteria 183925|Methanobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_413288_1 1408311.JNJM01000036_gene48 5.1e-10 69.3 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,2PS41@265975|Oribacterium 186801|Clostridia S Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail,TMP k59_321545_1 91604.ID47_06200 3.76e-06 53.1 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,47FEU@766|Rickettsiales 766|Rickettsiales S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_36028_1 929556.Solca_3424 5.09e-14 77.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NIIR@976|Bacteroidetes,1IPF7@117747|Sphingobacteriia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_308016_1 717785.HYPMC_1228 1.77e-09 59.7 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_294638_2 378806.STAUR_4206 3.33e-11 66.2 COG4122@1|root,COG4122@2|Bacteria,1RJW2@1224|Proteobacteria,4381W@68525|delta/epsilon subdivisions,2X3BX@28221|Deltaproteobacteria,2YVBH@29|Myxococcales 28221|Deltaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_199578_2 1520935.A0A0H3UB63_9CIRC 4.07e-28 115.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_24667_1 187303.BN69_1626 1.88e-16 85.5 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,36XZ4@31993|Methylocystaceae 28211|Alphaproteobacteria KT MT-A70 - - - - - - - - - - - - MT-A70,ParBc k59_93058_1 156889.Mmc1_2604 6.85e-32 129.0 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_279501_2 1054213.HMPREF9946_00111 1.3e-39 139.0 2BA7A@1|root,323MC@2|Bacteria,1RIHY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_427602_2 156889.Mmc1_2604 6.61e-76 239.0 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_131898_2 1385658.U5KPZ6_9VIRU 3.96e-107 328.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_333392_1 1416009.V9VCX0_9CAUD 2.74e-18 91.3 4QBY0@10239|Viruses,4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_131903_1 926562.Oweho_3235 1.22e-38 144.0 COG0270@1|root,COG0270@2|Bacteria,4NH5Z@976|Bacteroidetes,1I83E@117743|Flavobacteriia 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_185557_1 1618248.A0A0C5IB82_9CIRC 1.22e-97 296.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_239918_1 743299.Acife_1995 4.67e-53 181.0 COG3969@1|root,COG3969@2|Bacteria,1NBDM@1224|Proteobacteria,1RYRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoadenosine phosphosulfate ybdN - - - - - - - - - - - DUF3440,PAPS_reduct k59_404083_1 5786.XP_003284604.1 0.000174 51.6 COG5021@1|root,KOG4276@2759|Eukaryota,3XCJN@554915|Amoebozoa 554915|Amoebozoa O BTB And C-terminal Kelch - - - - - - - - - - - - BACK,BTB k59_227070_2 665942.HMPREF1022_02309 6.68e-20 90.1 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42M9T@68525|delta/epsilon subdivisions,2WNVF@28221|Deltaproteobacteria,2M8MI@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_integrase k59_430559_2 693272.E3T4R8_CROVB 5.06e-09 62.4 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage 10239|Viruses S N-acetylmuramoyl-L-alanine amidase activity - GO:0000270,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0005575,GO:0005975,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009253,GO:0009605,GO:0009607,GO:0009617,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0019012,GO:0019028,GO:0019538,GO:0030203,GO:0035821,GO:0043170,GO:0043207,GO:0044033,GO:0044035,GO:0044040,GO:0044041,GO:0044238,GO:0044278,GO:0044419,GO:0044423,GO:0050896,GO:0051672,GO:0051704,GO:0051707,GO:0055036,GO:0061783,GO:0071704,GO:0098015,GO:0098026,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - - k59_227076_2 69293.ENSGACP00000008265 2.48e-09 62.8 2CMNT@1|root,2QR3D@2759|Eukaryota,39UHX@33154|Opisthokonta,3B9U3@33208|Metazoa,3D2YM@33213|Bilateria,48A4K@7711|Chordata,493KK@7742|Vertebrata,49X80@7898|Actinopterygii 33208|Metazoa M Peptidoglycan recognition protein 2 PGLYRP2 GO:0001519,GO:0001817,GO:0001818,GO:0002218,GO:0002221,GO:0002253,GO:0002376,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002757,GO:0002758,GO:0002764,GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0006518,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008329,GO:0008745,GO:0009595,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0016019,GO:0016020,GO:0016045,GO:0016787,GO:0016810,GO:0016811,GO:0019730,GO:0023052,GO:0031179,GO:0031347,GO:0031349,GO:0032101,GO:0032649,GO:0032689,GO:0032814,GO:0032815,GO:0032823,GO:0032824,GO:0032826,GO:0032827,GO:0034641,GO:0038023,GO:0038187,GO:0040007,GO:0042742,GO:0042834,GO:0043207,GO:0043603,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044403,GO:0044419,GO:0044464,GO:0045087,GO:0045088,GO:0045089,GO:0045595,GO:0045596,GO:0045619,GO:0045620,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050727,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050830,GO:0050865,GO:0050866,GO:0050896,GO:0051093,GO:0051239,GO:0051241,GO:0051249,GO:0051250,GO:0051606,GO:0051704,GO:0051707,GO:0051716,GO:0060089,GO:0061783,GO:0065007,GO:0071704,GO:0080134,GO:0097367,GO:0098542,GO:0098543,GO:0098581,GO:1901564,GO:1902105,GO:1902106,GO:1903706,GO:1903707,GO:2000026 - ko:K01446 - - R04112 RC00064,RC00141 ko00000 - - - Amidase_2 k59_430561_2 1732201.A0A0N9N7I3_9CIRC 1.7e-37 141.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_388035_2 462590.A9J517_BPPYU 5.54e-67 221.0 4QBA2@10239|Viruses,4QV98@35237|dsDNA viruses no RNA stage,4QPPI@28883|Caudovirales,4QM0B@10699|Siphoviridae 10699|Siphoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_388035_3 194699.Q774Z7_BPBPP 3.44e-13 68.6 4QAZF@10239|Viruses,4QUTY@35237|dsDNA viruses no RNA stage,4QPH6@28883|Caudovirales,4QNEM@10744|Podoviridae 10744|Podoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_228431_2 1118235.CAJH01000004_gene362 1.12e-06 53.1 2EDJC@1|root,337F7@2|Bacteria,1NG7N@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_228431_4 388739.RSK20926_11829 1.2e-07 59.7 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_389208_2 886293.Sinac_4765 2e-13 77.4 COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,2J50K@203682|Planctomycetes 203682|Planctomycetes U Pkd domain containing protein - - 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - - k59_430838_1 1123054.KB907703_gene1420 6.6e-15 79.7 COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_430842_1 1609634.A0A0C5AFV4_9VIRU 2.38e-25 112.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_228489_2 595593.JREV01000049_gene1202 5.13e-19 85.5 COG0317@1|root,COG0317@2|Bacteria,2IHTX@201174|Actinobacteria 201174|Actinobacteria KT HD domain - - - - - - - - - - - - HD_4 k59_241081_3 411902.CLOBOL_06322 2.72e-24 96.3 2DNK9@1|root,32XXG@2|Bacteria,1V9Y9@1239|Firmicutes,24JHZ@186801|Clostridia,2227U@1506553|Lachnoclostridium 186801|Clostridia S Phage protein (N4 Gp49/phage Sf6 gene 66) family - - - - - - - - - - - - Phage_gp49_66 k59_82114_1 753085.F4YCV3_9CAUD 1.43e-124 380.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_176277_2 1611039.A0A0C5C3Z3_9CIRC 9.29e-58 193.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_122456_2 999547.KI421500_gene1194 0.0006 43.9 COG5614@1|root,COG5614@2|Bacteria,1N0CB@1224|Proteobacteria,2UBY8@28211|Alphaproteobacteria,281PX@191028|Leisingera 28211|Alphaproteobacteria S Phage head-tail joining protein - - - - - - - - - - - - Phage_H_T_join k59_162975_5 762903.Pedsa_0945 1.68e-30 121.0 COG3023@1|root,COG3023@2|Bacteria,4NQ2J@976|Bacteroidetes,1IY9G@117747|Sphingobacteriia 976|Bacteroidetes V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_997_1 1385658.U5KPZ6_9VIRU 3.06e-95 296.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_365353_2 1547437.LL06_07730 1.28e-17 78.2 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,43HR1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_243992_4 985255.APHJ01000018_gene3097 5.29e-57 190.0 COG5545@1|root,COG5545@2|Bacteria,4PMA3@976|Bacteroidetes,1IJP7@117743|Flavobacteriia 976|Bacteroidetes L VirE N-terminal domain - - - - - - - - - - - - DUF3987,PriCT_2,VirE,VirE_N k59_378946_2 691965.D4P7I3_9CAUD 1.65e-68 235.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_297779_5 1185876.BN8_03672 1.63e-07 62.4 COG2755@1|root,COG3064@1|root,COG4675@1|root,COG2755@2|Bacteria,COG3064@2|Bacteria,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein sprF - - ko:K18546 - - - - ko00000,ko01000,ko01002 - - - Pro_Al_protease,Trypsin k59_82349_2 1636271.A0A0E3M3Z1_9CAUD 1.92e-33 127.0 4QAIK@10239|Viruses,4QPEB@28883|Caudovirales,4QKNC@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_55716_3 330214.NIDE3430 8.87e-07 53.1 COG0438@1|root,COG0500@1|root,COG1216@1|root,COG2227@1|root,COG0438@2|Bacteria,COG0500@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568,ko:K20444 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_95683_1 1187128.I2GUC6_9CAUD 2.83e-39 142.0 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QJZQ@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_311969_1 411460.RUMTOR_01342 9.56e-44 150.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_311969_4 691965.D4P7D6_9CAUD 7.16e-46 169.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_231190_31 290317.Cpha266_0651 2.53e-29 119.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos,Metallophos_2 k59_231190_32 1357423.S5MCP0_9CAUD 1.15e-76 254.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_231190_34 1110702.G8GJ12_9CAUD 3.59e-76 245.0 4QASV@10239|Viruses,4QWD9@35237|dsDNA viruses no RNA stage,4QQ4N@28883|Caudovirales,4QIBN@10662|Myoviridae 10662|Myoviridae S recA bacterial DNA recombination protein - - - - - - - - - - - - - k59_231190_35 225937.HP15_1089 1.68e-44 161.0 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,1RZSJ@1236|Gammaproteobacteria,46A6N@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_16017_2 1380370.JIBA01000010_gene2421 1.35e-34 126.0 arCOG05626@1|root,2Z9D9@2|Bacteria,2IIAB@201174|Actinobacteria,4FHGY@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_2555_1 1150626.PHAMO_80087 1.32e-35 154.0 COG3941@1|root,COG3941@2|Bacteria,1PHQP@1224|Proteobacteria,2V9RW@28211|Alphaproteobacteria,2JWSI@204441|Rhodospirillales 204441|Rhodospirillales S Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Tape_meas_lam_C k59_393664_1 497964.CfE428DRAFT_3201 1.14e-23 103.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - - - - - - - - - - MT-A70,ParBc,RepB k59_164277_1 1788447.A0A190WHJ9_9CIRC 1.33e-90 276.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_71181_1 1124991.MU9_2939 1.58e-50 170.0 28IQ7@1|root,2Z8PY@2|Bacteria,1NA66@1224|Proteobacteria,1S212@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RecT family bet - - - - - - - - - - - RecT k59_205631_1 1168547.L7P648_9CIRC 2.63e-07 59.3 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_164278_1 305700.B447_10643 6.27e-33 122.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VW90@28216|Betaproteobacteria 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_43165_1 9031.ENSGALP00000007976 7.25e-06 53.1 KOG4179@1|root,KOG4179@2759|Eukaryota,38BZB@33154|Opisthokonta,3BB9G@33208|Metazoa,3CT83@33213|Bilateria,47Z13@7711|Chordata,48W32@7742|Vertebrata,4GMAW@8782|Aves 33208|Metazoa O inactive glycosyltransferase 25 family member CERCAM GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0007159,GO:0008150,GO:0016020,GO:0022610,GO:0044464,GO:0071944,GO:0098609 2.4.1.50 ko:K11703 ko00310,ko00514,map00310,map00514 - R03380 RC00005,RC00397 ko00000,ko00001,ko01000,ko01003 - GT25 - Glyco_tranf_2_4,Glyco_transf_25 k59_285789_4 1150474.JQJI01000011_gene54 4.57e-50 177.0 COG3723@1|root,COG3723@2|Bacteria,2GDKR@200918|Thermotogae 200918|Thermotogae L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_285789_9 1346791.M529_02355 2.61e-64 210.0 COG0175@1|root,COG0175@2|Bacteria,1QZJ1@1224|Proteobacteria,2U233@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_328806_3 1692255.A0A0K1RL13_9CIRC 1.12e-74 240.0 4QCY8@10239|Viruses,4QUMD@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_3993_1 565045.NOR51B_255 1.85e-13 76.6 COG0582@1|root,COG0582@2|Bacteria,1QJCD@1224|Proteobacteria,1THBF@1236|Gammaproteobacteria,1JBPV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_58700_9 314282.PCNPT3_06855 1.43e-11 77.4 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,2QH80@267894|Psychromonadaceae 1236|Gammaproteobacteria L DNA polymerase type-B family polB GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_58700_11 445686.E3SL93_9CAUD 7.29e-52 169.0 4QBKQ@10239|Viruses,4QVKF@35237|dsDNA viruses no RNA stage,4QQM7@28883|Caudovirales,4QIAS@10662|Myoviridae 10662|Myoviridae S Bacteriophage translational regulator - - - - - - - - - - - - - k59_273585_1 72664.XP_006389927.1 1.14e-19 93.6 COG0468@1|root,KOG1433@2759|Eukaryota,37MTD@33090|Viridiplantae,3G7ZH@35493|Streptophyta,3HR52@3699|Brassicales 35493|Streptophyta L DNA repair protein recA - GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_125214_1 155515.JP36_01005 1.8e-11 72.8 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1Y7ZN@135625|Pasteurellales 135625|Pasteurellales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_4174_1 1567471.A0A0B4ZY07_9CAUD 5.75e-06 58.2 4QAY9@10239|Viruses,4QPAN@28883|Caudovirales,4QKV1@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_4174_4 1308866.J416_05543 9.07e-14 82.4 COG0553@1|root,COG0553@2|Bacteria,1TQ5E@1239|Firmicutes,4H9WB@91061|Bacilli,46ZRK@74385|Gracilibacillus 91061|Bacilli KL SNF2 family N-terminal domain yqhH - - - - - - - - - - - Helicase_C,SNF2_N k59_17977_2 1244083.CSUNSWCD_775 0.000112 48.5 28IGK@1|root,2Z8I1@2|Bacteria,1RAH7@1224|Proteobacteria,42WJZ@68525|delta/epsilon subdivisions,2YQJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_86270_2 1123008.KB905702_gene2330 1.38e-32 119.0 COG3179@1|root,COG3179@2|Bacteria,4NQZS@976|Bacteroidetes 976|Bacteroidetes S Chitinase class I - - - - - - - - - - - - Glyco_hydro_19 k59_31888_1 366394.Smed_1667 4.58e-23 105.0 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,4BGSK@82115|Rhizobiaceae 28211|Alphaproteobacteria KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70,ParBc k59_261074_1 118168.MC7420_6229 8.49e-08 58.5 COG0587@1|root,COG0587@2|Bacteria,1G0VY@1117|Cyanobacteria,1H9W4@1150|Oscillatoriales 1117|Cyanobacteria L OB-fold nucleic acid binding domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - HHH_6,tRNA_anti-codon k59_409318_1 1417599.U6C865_9CAUD 1.13e-18 86.3 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_395216_1 1692244.A0A0K1RLR5_9CIRC 4.36e-66 212.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_232781_1 383372.Rcas_1931 7.8e-27 120.0 COG0433@1|root,COG0433@2|Bacteria,2G8H0@200795|Chloroflexi,37743@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_301159_5 1121896.JMLU01000052_gene1260 2.72e-36 142.0 2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_20185_4 1540098.A0A0A0RQI2_9CAUD 1.86e-103 332.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_20185_6 1217705.F900_00002 2.25e-26 99.8 2BTV0@1|root,32P2Q@2|Bacteria,1Q8QF@1224|Proteobacteria,1RTBA@1236|Gammaproteobacteria,3NSHE@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_20185_7 1196323.ALKF01000200_gene2705 2.03e-61 199.0 COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,4H9QS@91061|Bacilli,26T1B@186822|Paenibacillaceae 91061|Bacilli F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_20190_1 1220714.L7TNN0_9CAUD 1.74e-22 101.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_101349_4 1100720.ALKN01000018_gene1726 9.37e-20 101.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_47181_2 203124.Tery_4958 4.76e-66 230.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G15Q@1117|Cyanobacteria,1H7TC@1150|Oscillatoriales 2|Bacteria L tpr repeat - - - - - - - - - - - - CHAT,Clp_N,TPR_10 k59_275682_6 1035308.AQYY01000002_gene859 5.73e-14 85.1 COG1409@1|root,COG4932@1|root,COG1409@2|Bacteria,COG4932@2|Bacteria,1UNMY@1239|Firmicutes,25H2U@186801|Clostridia,267I4@186807|Peptococcaceae 2|Bacteria M domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3,CHU_C,Metallophos k59_182074_1 272632.MSC_0186 3.4e-10 65.9 COG2189@1|root,COG2189@2|Bacteria,3WSW7@544448|Tenericutes 544448|Tenericutes L Belongs to the N(4) N(6)-methyltransferase family hpaIM - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_347734_3 1333523.L593_06050 1.22e-12 78.2 COG5410@1|root,arCOG09550@2157|Archaea,2XW1V@28890|Euryarchaeota,23Z33@183963|Halobacteria 183963|Halobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - - k59_90939_2 1304874.JAFY01000007_gene2441 1.87e-05 54.7 COG4974@1|root,COG4974@2|Bacteria,3T9Y4@508458|Synergistetes 508458|Synergistetes L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_147582_2 1327036.R4JHP8_9CAUD 1.06e-17 89.4 4QCEF@10239|Viruses,4QVWZ@35237|dsDNA viruses no RNA stage,4QTBA@28883|Caudovirales,4QMGR@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_36510_1 1207063.P24_15174 2.72e-16 92.8 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - ko:K10953 ko05110,map05110 - - - ko00000,ko00001,ko02042 - - - Peptidase_C80,RtxA,TMP_2 k59_62731_1 314275.MADE_000001022545 1.01e-24 108.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,465QU@72275|Alteromonadaceae 1236|Gammaproteobacteria KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,Mrr_cat,SNF2_N,SWIM k59_147586_1 462590.A9J517_BPPYU 7.52e-54 182.0 4QBA2@10239|Viruses,4QV98@35237|dsDNA viruses no RNA stage,4QPPI@28883|Caudovirales,4QM0B@10699|Siphoviridae 10699|Siphoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_147586_3 279383.Q5DN86_9CAUD 1.01e-20 92.4 4QG7K@10239|Viruses,4QZQI@35237|dsDNA viruses no RNA stage,4QQZP@28883|Caudovirales,4QN68@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_425786_1 1034101.G1D1F5_9CAUD 1.57e-52 178.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_183771_2 1040987.AZUY01000006_gene1805 6.01e-23 101.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,43K5X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_347968_2 1317124.DW2_03434 7.92e-09 66.2 COG3391@1|root,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,2XM69@285107|Thioclava 28211|Alphaproteobacteria S GTA TIM-barrel-like domain - - - - - - - - - - - - GTA_TIM,Phage-tail_3 k59_372287_1 1140003.I573_01161 3.16e-27 110.0 2E1MQ@1|root,32WYT@2|Bacteria,1VB8R@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_129475_2 762982.HMPREF9442_00544 2.87e-29 109.0 2C7AV@1|root,32S15@2|Bacteria,4NUJ2@976|Bacteroidetes,2FXZ4@200643|Bacteroidia 976|Bacteroidetes S zinc-finger-containing domain - - - - - - - - - - - - DUF3268 k59_147598_1 1463934.JOCF01000062_gene4346 2.39e-16 82.8 COG1475@1|root,COG1475@2|Bacteria,2IAY7@201174|Actinobacteria 201174|Actinobacteria K Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - ParBc k59_332103_2 1519439.JPJG01000087_gene709 3.15e-08 58.9 COG1896@1|root,COG1896@2|Bacteria,1TSDU@1239|Firmicutes,24FT8@186801|Clostridia,2N743@216572|Oscillospiraceae 186801|Clostridia S HD containing hydrolase-like enzyme yfbR - 3.1.3.89 ko:K07023,ko:K08722 ko00240,ko01100,map00240,map01100 - R01569,R01664,R01968,R02088,R02102,R10776 RC00017 ko00000,ko00001,ko01000 - - - HD_2,HD_3 k59_251484_1 1173762.S4TP20_9CAUD 6.46e-64 214.0 4QB3X@10239|Viruses,4QWKP@35237|dsDNA viruses no RNA stage,4QPEE@28883|Caudovirales,4QNCI@10744|Podoviridae 10744|Podoviridae S VWA-like domain (DUF2201) - - - - - - - - - - - - - k59_157739_1 536019.Mesop_3732 1.71e-22 100.0 COG0553@1|root,COG0553@2|Bacteria,1R7CK@1224|Proteobacteria,2U228@28211|Alphaproteobacteria,43I7K@69277|Phyllobacteriaceae 28211|Alphaproteobacteria KL DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_116072_2 1210884.HG799462_gene9024 2.9e-33 130.0 COG0265@1|root,COG0265@2|Bacteria,2J26A@203682|Planctomycetes 203682|Planctomycetes O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_265919_5 396595.TK90_2749 1.62e-33 117.0 2DSMC@1|root,33GP4@2|Bacteria,1NCDH@1224|Proteobacteria,1T10M@1236|Gammaproteobacteria,1X1TS@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4326) - - - - - - - - - - - - DUF4326 k59_237546_1 266264.Rmet_5541 5.98e-159 447.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,1K13F@119060|Burkholderiaceae 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_237546_2 266264.Rmet_5542 1.53e-68 207.0 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2VSJA@28216|Betaproteobacteria,1K8EV@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase IS3 IS911 family protein - - - - - - - - - - - - HTH_Tnp_1 k59_105348_1 742740.HMPREF9474_02303 1.07e-83 281.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,221YV@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_64443_1 999550.KI421507_gene2020 2.65e-07 59.3 COG4675@1|root,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Collar,Phage_fiber_2 k59_117725_1 2340.JV46_13390 2.05e-51 183.0 COG1996@1|root,COG1996@2|Bacteria 2|Bacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4379 k59_307946_1 388051.AUFE01000035_gene4020 1.36e-15 81.3 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_64453_3 232721.Ajs_0943 1.24e-13 64.7 2BZU4@1|root,33P2G@2|Bacteria,1NMV2@1224|Proteobacteria,2VYVW@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_93266_1 365044.Pnap_0961 2.55e-39 149.0 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,2VPIR@28216|Betaproteobacteria 28216|Betaproteobacteria OU Belongs to the peptidase S14 family - - - - - - - - - - - - CLP_protease k59_172758_2 1028806.GGE_0242 3.72e-111 328.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria,1Y9BE@135625|Pasteurellales 135625|Pasteurellales H Cytosine-specific methyltransferase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_118034_1 1168478.I6S2F3_9CAUD 5.97e-66 209.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_255539_2 426368.MmarC7_0502 1.12e-41 143.0 arCOG06669@1|root,arCOG06669@2157|Archaea,2XV2H@28890|Euryarchaeota,23RJC@183939|Methanococci 183939|Methanococci - - - - - - - - - - - - - - - k59_255558_2 1157708.KB907450_gene5441 1.32e-09 65.1 COG5434@1|root,COG5434@2|Bacteria,1RCW1@1224|Proteobacteria,2W4G2@28216|Betaproteobacteria 28216|Betaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_13086_1 1144307.PMI04_03650 5.39e-64 217.0 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,2TUJN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_13086_2 794846.AJQU01000075_gene3385 2.22e-57 182.0 2BMD6@1|root,32FXJ@2|Bacteria,1MYWI@1224|Proteobacteria,2U99V@28211|Alphaproteobacteria,4BJEP@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_335540_1 255470.cbdbA1348 5.78e-07 57.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi,34CQM@301297|Dehalococcoidia 301297|Dehalococcoidia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_376921_2 1207063.P24_15029 4.17e-15 74.3 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,2TU8N@28211|Alphaproteobacteria,2JXEZ@204441|Rhodospirillales 204441|Rhodospirillales L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_376922_1 1165094.RINTHH_3920 7.13e-70 226.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_226849_1 478749.BRYFOR_08513 2.1e-19 102.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Amidase_2,LysM,PG_binding_1 k59_430537_1 1788445.A0A190WHA3_9CIRC 1.64e-39 147.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_283132_2 868595.Desca_1778 2.53e-21 94.4 COG1191@1|root,COG1191@2|Bacteria,1TP9K@1239|Firmicutes,248M0@186801|Clostridia,260GN@186807|Peptococcaceae 186801|Clostridia K TIGRFAM RNA polymerase sigma factor, FliA WhiG fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_311094_2 1122997.AUDD01000007_gene815 2.36e-183 522.0 COG0553@1|root,COG0553@2|Bacteria,2H20C@201174|Actinobacteria,4DTBP@85009|Propionibacteriales 201174|Actinobacteria KL DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_337789_1 580332.Slit_1922 2.32e-69 229.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2VM59@28216|Betaproteobacteria 28216|Betaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_364821_1 691965.D4P7D3_9CAUD 1.52e-73 234.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_41159_3 1122947.FR7_2498 1.68e-22 99.0 COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes,4H4NQ@909932|Negativicutes 909932|Negativicutes H Cytosine-specific methyltransferase - - - - - - - - - - - - DNA_methylase k59_135421_2 211165.AJLN01000058_gene2820 7.75e-06 50.4 COG0603@1|root,COG0603@2|Bacteria,1G24C@1117|Cyanobacteria,1JJT6@1189|Stigonemataceae 1117|Cyanobacteria F Asparagine synthase queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_418515_1 1041826.FCOL_06775 3.42e-11 64.7 COG4696@1|root,COG4696@2|Bacteria,4NNW2@976|Bacteroidetes,1I23U@117743|Flavobacteriia,2NWAR@237|Flavobacterium 976|Bacteroidetes S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - PRA-PH k59_418515_6 488538.SAR116_0386 1.53e-35 128.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,4BRKK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_270289_3 1116472.MGMO_205c00030 3.56e-115 350.0 28IN7@1|root,2Z8NM@2|Bacteria,1NRFQ@1224|Proteobacteria,1SKG7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Capsid protein (F protein) - - - - - - - - - - - - Phage_F k59_270289_7 1286632.P278_33700 1.03e-77 259.0 28I9J@1|root,2Z8C8@2|Bacteria,4P06R@976|Bacteroidetes,1I7XB@117743|Flavobacteriia 976|Bacteroidetes S Bacteriophage replication gene A protein (GPA) - - - - - - - - - - - - Phage_GPA k59_270289_8 1116472.MGMO_205c00050 7.04e-32 117.0 28HVF@1|root,2Z81Q@2|Bacteria,1NZPF@1224|Proteobacteria,1SRZ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage scaffolding protein D - - - - - - - - - - - - gpD k59_108429_1 379066.GAU_1822 2.97e-09 68.6 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,HTH_31,N_BRCA1_IG k59_297326_1 648333.Q77NV0_PFDNG 1.01e-70 249.0 4QEBH@10239|Viruses,4QUMC@29258|ssDNA viruses 10239|Viruses S Capsid protein VP4 - - - - - - - - - - - - - k59_297326_2 648250.VNCS_JDNVP 2.17e-71 238.0 4QAUG@10239|Viruses,4QUM5@29258|ssDNA viruses 10239|Viruses L Parvovirus non-structural protein NS1 - GO:0001906,GO:0001907,GO:0005575,GO:0008150,GO:0009889,GO:0010556,GO:0010941,GO:0010942,GO:0016032,GO:0018995,GO:0019048,GO:0019051,GO:0019054,GO:0019056,GO:0019058,GO:0019079,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031341,GO:0031343,GO:0031640,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0035821,GO:0039526,GO:0039592,GO:0039656,GO:0039685,GO:0039693,GO:0042025,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044071,GO:0044215,GO:0044216,GO:0044217,GO:0044364,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0044533,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051726,GO:0051817,GO:0051818,GO:0051883,GO:0052026,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052312,GO:0052330,GO:0052433,GO:0052501,GO:0060139,GO:0060153,GO:0060255,GO:0065007,GO:0080090,GO:2001141 - - - - - - - - - - - k59_189364_1 760939.E5EPG0_9CAUD 0.000207 48.1 4QFBV@10239|Viruses,4QUVM@35237|dsDNA viruses no RNA stage,4QS5K@28883|Caudovirales,4QJGR@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_243503_1 1234888.K0A2J2_9VIRU 1.21e-63 213.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_324417_1 428125.CLOLEP_01412 6.32e-48 175.0 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia,3WMZ3@541000|Ruminococcaceae 186801|Clostridia S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_391905_1 1465751.W8QE76_9VIRU 3.08e-66 205.0 4QAW0@10239|Viruses,4QXED@35237|dsDNA viruses no RNA stage 10239|Viruses S Deoxynucleoside kinase - - - - - - - - - - - - - k59_135542_2 411460.RUMTOR_00791 1.9e-05 48.1 COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,24XIM@186801|Clostridia,3Y0YK@572511|Blautia 186801|Clostridia K Sigma-70 factor, region 1.2 - - - - - - - - - - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_285010_1 880073.Calab_1510 6.06e-07 50.1 2CG0S@1|root,33AN9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_163415_1 1154757.Q5C_03090 0.000555 47.8 COG1372@1|root,COG1783@1|root,COG1372@2|Bacteria,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,4HDMY@91061|Bacilli,4AX0D@81850|Leuconostocaceae 91061|Bacilli L Phage terminase large subunit - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_392899_1 1321782.HMPREF1986_00608 6.13e-29 114.0 COG1475@1|root,COG1475@2|Bacteria,1V2SD@1239|Firmicutes,24J2M@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_393006_17 1124780.ANNU01000013_gene3877 1.35e-251 732.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,47NQV@768503|Cytophagia 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_393006_20 1392488.JHZY01000004_gene1743 4.89e-14 68.9 2FJGN@1|root,34B68@2|Bacteria,4P5T6@976|Bacteroidetes,1IA9K@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_393006_28 1157640.AQWO01000014_gene1333 3.95e-13 72.4 COG1403@1|root,COG1403@2|Bacteria,2HYBZ@201174|Actinobacteria 201174|Actinobacteria V HNH nucleases - - - - - - - - - - - - HNH,HNH_3 k59_339891_1 1122201.AUAZ01000017_gene2949 4.19e-53 183.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,46B9P@72275|Alteromonadaceae 1236|Gammaproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_217388_1 305700.B447_10643 3.5e-30 115.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VW90@28216|Betaproteobacteria 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_393007_1 1054213.HMPREF9946_02152 1.48e-12 74.7 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TTEX@28211|Alphaproteobacteria,2JVUB@204441|Rhodospirillales 204441|Rhodospirillales S Terminase - - - - - - - - - - - - Terminase_1 k59_366251_1 329381.Q4TZV0_9CAUD 3.08e-28 109.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_206591_3 365528.KB891217_gene1456 5.83e-42 144.0 2DW0U@1|root,33Y19@2|Bacteria,2IP9D@201174|Actinobacteria 201174|Actinobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_341794_1 143224.JQMD01000002_gene912 3.47e-54 196.0 COG1061@1|root,COG1061@2|Bacteria,4NECV@976|Bacteroidetes,1HWX1@117743|Flavobacteriia 976|Bacteroidetes L type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_272710_1 1788452.A0A190WHG0_9CIRC 2.91e-23 101.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_139352_1 10685.B6V2M5_BPSP1 5.48e-22 103.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_354976_1 31535.Q9XJT3_BPD3 1.89e-24 104.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_111334_2 1439940.BAY1663_02360 1.72e-35 134.0 28JTG@1|root,2Z9IR@2|Bacteria,1PCXZ@1224|Proteobacteria,1SIJB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_232143_1 1122970.AUHC01000002_gene1220 1.81e-29 119.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2K2BG@204457|Sphingomonadales 204457|Sphingomonadales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_179074_2 322710.Avin_51170 1.95e-06 54.3 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins psmE - - - - - - - - - - - Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C k59_85341_2 479437.Elen_0815 0.000305 43.5 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - Herpes_Helicase,PIF1,UvrD_C_2 k59_246654_1 1122604.JONR01000025_gene4585 4.53e-05 45.1 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_246654_2 562970.Btus_1093 4.31e-18 83.2 COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,4HAIS@91061|Bacilli,27884@186823|Alicyclobacillaceae 91061|Bacilli L MgsA AAA+ ATPase C terminal rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_300394_1 82996.sch_09905 1.97e-32 131.0 COG0840@1|root,COG4733@1|root,COG0840@2|Bacteria,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,401CF@613|Serratia 1236|Gammaproteobacteria NT Putative phage tail protein - - - - - - - - - - - - DUF1983,DUF3672,Phage-tail_3 k59_421188_1 1113547.A0A060DBD5_9CAUD 7.85e-07 53.5 4QC5Z@10239|Viruses,4QUNP@35237|dsDNA viruses no RNA stage,4QPGX@28883|Caudovirales 28883|Caudovirales S extracellular region - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_421188_2 1282876.BAOK01000002_gene742 3.34e-20 83.6 2E4KF@1|root,32ZFE@2|Bacteria,1NCMR@1224|Proteobacteria,2UHT7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_31111_1 1197477.IA57_04380 3.5e-121 378.0 COG1002@1|root,COG1002@2|Bacteria,4NFKA@976|Bacteroidetes,1HZZE@117743|Flavobacteriia 976|Bacteroidetes V Type II restriction enzyme, methylase subunits - - - - - - - - - - - - N6_Mtase k59_125922_10 1121459.AQXE01000008_gene943 3.19e-07 54.7 COG0476@1|root,COG0476@2|Bacteria,1R8X7@1224|Proteobacteria,4304A@68525|delta/epsilon subdivisions,2WVCP@28221|Deltaproteobacteria 28221|Deltaproteobacteria H ThiF family - - - - - - - - - - - - ThiF k59_125922_11 1158294.JOMI01000003_gene2367 4.44e-116 346.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,2FN5D@200643|Bacteroidia 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_87199_2 1123258.AQXZ01000009_gene1488 2.85e-12 71.6 COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2I54D@201174|Actinobacteria,4G9ME@85025|Nocardiaceae 201174|Actinobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23,SLT,SLT_2 k59_344080_1 130081.XP_005702646.1 2.09e-36 140.0 COG1678@1|root,KOG1567@2759|Eukaryota 2759|Eukaryota K ribonucleoside-diphosphate reductase activity RNR2 GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006240,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009147,GO:0009148,GO:0009165,GO:0009185,GO:0009186,GO:0009189,GO:0009193,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009215,GO:0009216,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009653,GO:0009987,GO:0012505,GO:0016043,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030587,GO:0031288,GO:0031967,GO:0031975,GO:0032502,GO:0032991,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046062,GO:0046131,GO:0046385,GO:0046483,GO:0046704,GO:0046872,GO:0046914,GO:0046983,GO:0048856,GO:0051063,GO:0051186,GO:0051188,GO:0051259,GO:0051262,GO:0051290,GO:0051291,GO:0051703,GO:0051704,GO:0055086,GO:0055114,GO:0061731,GO:0065003,GO:0071704,GO:0071840,GO:0072521,GO:0072527,GO:0072528,GO:0090407,GO:0090702,GO:0099120,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1902494,GO:1990204 1.17.4.1 ko:K10808 ko00230,ko00240,ko00480,ko00983,ko01100,ko04115,map00230,map00240,map00480,map00983,map01100,map04115 M00053 R02017,R02019,R02024,R08363,R08364,R11893 RC00613,RC01003 ko00000,ko00001,ko00002,ko01000,ko03400 - - iMM904.YGR180C,iMM904.YJL026W,iND750.YGR180C,iND750.YJL026W Ribonuc_red_sm k59_288156_1 1440052.EAKF1_ch0453c 0.000817 43.9 2DN6T@1|root,32VV9@2|Bacteria,1N4C4@1224|Proteobacteria,1SAK2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S zinc-ribbon domain - - - - - - - - - - - - zf-ribbon_3 k59_262084_1 329726.AM1_2151 5.48e-11 65.5 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1G1P1@1117|Cyanobacteria 1117|Cyanobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_262084_2 1054217.TALC_00003 2.62e-25 101.0 COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,241PS@183967|Thermoplasmata 183967|Thermoplasmata F MafB19-like deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_87203_1 5759.rna_EHI_193630-1 9.06e-24 103.0 2CSEE@1|root,2RBK2@2759|Eukaryota,3X9MH@554915|Amoebozoa 554915|Amoebozoa G RNA helicase - - - - - - - - - - - - RNA_helicase k59_87215_3 1122201.AUAZ01000021_gene3143 6.32e-25 97.4 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,1S6D5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase M15 - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_181161_1 1046714.AMRX01000006_gene3179 4.04e-14 80.1 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,1S4X6@1236|Gammaproteobacteria,46AXH@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_167467_2 1158150.KB906242_gene236 1.08e-26 105.0 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,1SQ0T@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_35011_1 111781.Lepto7376_3702 5.05e-22 101.0 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_182562_1 383372.Rcas_2728 3.56e-15 75.5 COG2189@1|root,COG2189@2|Bacteria 2|Bacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571,ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_168936_1 477974.Daud_2108 3.47e-56 208.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,261EE@186807|Peptococcaceae 186801|Clostridia O Subtilase family - - - - - - - - - - - - Cohesin,Peptidase_S8,SLH k59_78001_1 1121937.AUHJ01000007_gene1937 1.75e-59 197.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RP8Z@1236|Gammaproteobacteria,467QB@72275|Alteromonadaceae 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_235251_1 523845.AQXV01000055_gene138 2.94e-05 52.8 COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,23QIW@183939|Methanococci 183939|Methanococci S PFAM ATPase associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_320274_1 1219035.NT2_15_00150 1.73e-19 91.7 COG0175@1|root,COG0175@2|Bacteria,1QZJ1@1224|Proteobacteria,2U233@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_195754_2 1172188.KB911820_gene2845 3.28e-39 135.0 2F5XY@1|root,33YGK@2|Bacteria,2H6A2@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_195754_3 1172188.KB911820_gene2842 1.78e-180 520.0 28MN1@1|root,2ZAXN@2|Bacteria,2H2TF@201174|Actinobacteria 201174|Actinobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_360181_1 1122991.BAIZ01000025_gene1859 5.2e-72 226.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia 976|Bacteroidetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_156037_1 96561.Dole_3191 3.29e-09 64.7 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2MHNC@213118|Desulfobacterales 28221|Deltaproteobacteria J 3'-5' exonuclease rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_371063_1 1519464.HY22_07965 2.98e-15 81.6 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity rtpR - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC k59_264420_1 1175654.A0A0S0NAE3_9CAUD 8.25e-46 168.0 4QB5I@10239|Viruses,4QWYV@35237|dsDNA viruses no RNA stage,4QTTK@28883|Caudovirales,4QM8X@10699|Siphoviridae 10699|Siphoviridae S ATP-dependent DNA helicase activity - - - - - - - - - - - - - k59_320733_1 856793.MICA_118 3.24e-10 63.5 COG4447@1|root,COG5295@1|root,COG4447@2|Bacteria,COG5295@2|Bacteria,1NDSM@1224|Proteobacteria,2UK7X@28211|Alphaproteobacteria 28211|Alphaproteobacteria UW Chaperone of endosialidase - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Peptidase_S74 k59_292595_2 1196323.ALKF01000191_gene5623 1.76e-10 67.0 COG3266@1|root,COG3266@2|Bacteria,1UP42@1239|Firmicutes 1239|Firmicutes S Collagen triple helix repeat (20 copies) - - - - - - - - - - - - Collagen k59_372800_1 1101189.AQUO01000001_gene3052 0.000342 52.0 COG3064@1|root,COG3064@2|Bacteria,1NQ5T@1224|Proteobacteria,2UK7G@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - PTR k59_23301_1 378806.STAUR_0158 1.84e-14 84.7 COG4124@1|root,COG4124@2|Bacteria,1N5GF@1224|Proteobacteria 1224|Proteobacteria G Belongs to the glycosyl hydrolase 26 family - - - - - - - - - - - - Glyco_hydro_26 k59_332455_2 691965.D4P7D6_9CAUD 2.54e-41 154.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_306634_2 691965.D4P7D3_9CAUD 3.6e-22 97.4 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_116839_3 1115512.EH105704_01_02490 5.96e-10 61.6 2E1TC@1|root,32X37@2|Bacteria,1N1AU@1224|Proteobacteria,1SNCF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_116839_5 888832.HMPREF9420_1947 1.7e-75 233.0 COG0207@1|root,COG0207@2|Bacteria,4NJ7H@976|Bacteroidetes,2FMDG@200643|Bacteroidia 976|Bacteroidetes F Psort location Cytoplasmic, score thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_363227_1 1121895.Q765_03270 2.28e-14 80.1 2EAST@1|root,334US@2|Bacteria,4NRGD@976|Bacteroidetes,1I583@117743|Flavobacteriia,2NU1I@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_293013_2 1123487.KB892865_gene1375 1.4e-09 57.8 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,2KZJK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_171230_1 1204521.I7A8M7_9CAUD 7.77e-87 286.0 4QCZC@10239|Viruses,4QX3V@35237|dsDNA viruses no RNA stage,4QRH3@28883|Caudovirales,4QHVR@10662|Myoviridae 10662|Myoviridae S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_9482_1 1499689.CCNN01000007_gene2132 3.51e-09 65.1 COG3864@1|root,COG3864@2|Bacteria,1UY2M@1239|Firmicutes,25D3Q@186801|Clostridia,36EXP@31979|Clostridiaceae 186801|Clostridia S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_50202_2 1327036.R4JQQ9_9CAUD 1.34e-27 107.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_349088_1 159450.NH14_31700 8.25e-39 143.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1KCGC@119060|Burkholderiaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_426652_1 345201.VF355_IIV3 3.51e-92 273.0 4QC22@10239|Viruses,4QUTC@35237|dsDNA viruses no RNA stage 10239|Viruses S NLI interacting factor-like phosphatase - - - - - - - - - - - - - k59_426652_2 1465751.W8QE94_9VIRU 3.59e-11 67.8 4QF8K@10239|Viruses,4QXCJ@35237|dsDNA viruses no RNA stage 10239|Viruses S Zinc finger, C3HC4 type (RING finger) - - - - - - - - - - - - - k59_171238_2 1122201.AUAZ01000026_gene1209 3.1e-78 248.0 2C6N9@1|root,32RHI@2|Bacteria,1P488@1224|Proteobacteria,1SUTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_278373_1 691965.D4P7D9_9CAUD 1.27e-53 181.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_92030_1 479431.Namu_4628 1.88e-14 72.4 COG4725@1|root,COG4725@2|Bacteria,2IIR3@201174|Actinobacteria,4EVXR@85013|Frankiales 201174|Actinobacteria KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_92030_3 397291.C804_01976 7.72e-08 54.3 COG4725@1|root,COG4725@2|Bacteria,1TSJV@1239|Firmicutes,25D3M@186801|Clostridia 186801|Clostridia KT MT-A70 - - - - - - - - - - - - MT-A70 k59_254458_2 1217710.F969_01380 4.02e-09 62.8 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,1S089@1236|Gammaproteobacteria,3NN0B@468|Moraxellaceae 1236|Gammaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_106665_3 1118235.CAJH01000027_gene1956 9.86e-09 60.1 COG0739@1|root,COG0739@2|Bacteria,1R8E7@1224|Proteobacteria,1RZDF@1236|Gammaproteobacteria,1X9EG@135614|Xanthomonadales 135614|Xanthomonadales M BlaR1 peptidase M56 - - - - - - - - - - - - Peptidase_M23,Peptidase_M56 k59_386393_1 194802.Q8LT46_9CAUD 4.66e-10 65.1 4QE6E@10239|Viruses,4QV23@35237|dsDNA viruses no RNA stage,4QTFG@28883|Caudovirales 28883|Caudovirales S protein dimerization activity - - - - - - - - - - - - - k59_186810_1 1215092.PA6_014_00520 5.85e-48 163.0 COG5532@1|root,COG5532@2|Bacteria,1N1S9@1224|Proteobacteria,1S30J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized conserved protein (DUF2303) - - - - - - - - - - - - DUF2303 k59_11820_1 1618248.A0A0C5IB82_9CIRC 1.78e-38 140.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_224784_1 247156.NFA_510 3.85e-09 67.8 COG5280@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria,4G9E7@85025|Nocardiaceae 201174|Actinobacteria M phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail,SLT k59_417027_1 1121028.ARQE01000019_gene2660 1.11e-06 55.8 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_65809_1 1035193.HMPREF9073_00108 0.000894 47.0 COG5362@1|root,COG5362@2|Bacteria,4PAI5@976|Bacteroidetes,1IMS4@117743|Flavobacteriia,1ET56@1016|Capnocytophaga 976|Bacteroidetes S TIGRFAM Phage - - - - - - - - - - - - - k59_118989_1 319225.Plut_0088 7.65e-23 90.9 COG0724@1|root,COG0724@2|Bacteria,1FE64@1090|Chlorobi 1090|Chlorobi S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_402201_2 1197951.I6S6I0_9CAUD 2.18e-20 86.3 4QB0U@10239|Viruses,4QZQJ@35237|dsDNA viruses no RNA stage,4QR5X@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_174218_1 1429767.W6B150_9CAUD 4.4e-13 70.5 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_161396_1 649747.HMPREF0083_01035 6.44e-65 213.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,4HHQR@91061|Bacilli 91061|Bacilli H C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_25964_2 937777.Deipe_2050 5.86e-42 147.0 29WNC@1|root,33GS8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_174225_1 7918.ENSLOCP00000005016 2.16e-26 118.0 COG0507@1|root,KOG0987@2759|Eukaryota,38G42@33154|Opisthokonta,3BASM@33208|Metazoa,3CY11@33213|Bilateria,488E0@7711|Chordata,48Z83@7742|Vertebrata,49T90@7898|Actinopterygii 33208|Metazoa L DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability PIF1 GO:0000002,GO:0000166,GO:0000228,GO:0000287,GO:0000781,GO:0000784,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004857,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0006996,GO:0007005,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010521,GO:0010556,GO:0010558,GO:0010605,GO:0010639,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017116,GO:0019219,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032204,GO:0032205,GO:0032210,GO:0032211,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033044,GO:0033677,GO:0033678,GO:0033680,GO:0033682,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042162,GO:0042623,GO:0043086,GO:0043139,GO:0043141,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0044806,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051053,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051276,GO:0051338,GO:0051348,GO:0051972,GO:0051974,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0098687,GO:0098772,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1904356,GO:1904357,GO:2000112,GO:2000113,GO:2000278,GO:2000279,GO:2001251 3.6.4.12 ko:K15255 - - - - ko00000,ko01000,ko03029,ko03032 - - - Herpes_Helicase,PIF1 k59_374802_1 1279009.ADICEAN_01841 2.96e-119 385.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,47JEH@768503|Cytophagia 976|Bacteroidetes F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_224795_3 1313421.JHBV01000016_gene5458 5.05e-13 69.7 COG1705@1|root,COG1705@2|Bacteria,4NEER@976|Bacteroidetes,1IP5H@117747|Sphingobacteriia 976|Bacteroidetes NU COG1705 Muramidase (flagellum-specific) lytG - - - - - - - - - - - Glucosaminidase,LysM k59_281103_2 1229172.JQFA01000001_gene2038 1.61e-58 207.0 2DN3V@1|root,32VD9@2|Bacteria,1G7V0@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_374803_1 935866.JAER01000006_gene3384 9.3e-17 77.4 2EGYA@1|root,33AQE@2|Bacteria,2GPUQ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_65833_1 926569.ANT_21890 9.53e-27 105.0 COG1796@1|root,COG1796@2|Bacteria 2|Bacteria L DNA-directed DNA polymerase activity polX - - ko:K02347,ko:K04477 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_134881_1 1027273.GZ77_09015 7.21e-72 226.0 28HHC@1|root,2Z7T2@2|Bacteria,1PZ57@1224|Proteobacteria,1SRT1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - AAA_24 k59_134881_2 357276.EL88_11255 9.1e-27 110.0 2CWXD@1|root,32T0J@2|Bacteria,4P63N@976|Bacteroidetes,2FYM4@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_283248_1 1492922.GY26_01890 1.22e-35 139.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RP8Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K terminase - - - - - - - - - - - - Terminase_1 k59_53963_1 1506583.JQJY01000010_gene1187 4.43e-06 55.5 COG2911@1|root,COG3209@1|root,COG4677@1|root,COG5492@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG4677@2|Bacteria,COG5492@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia,2NSCF@237|Flavobacterium 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,Laminin_G_3,SprB k59_107915_3 665942.HMPREF1022_00118 3.58e-22 96.7 2C9JF@1|root,32RPD@2|Bacteria,1N8CG@1224|Proteobacteria,42REW@68525|delta/epsilon subdivisions,2WNQ1@28221|Deltaproteobacteria,2MB30@213115|Desulfovibrionales 28221|Deltaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_323708_4 1234888.K0A2J2_9VIRU 1.75e-131 394.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_107932_1 1234888.K0A2J2_9VIRU 6.51e-40 148.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_121424_1 314230.DSM3645_05250 1.76e-07 59.3 COG4968@1|root,COG4968@2|Bacteria,2J07S@203682|Planctomycetes 203682|Planctomycetes NU Pfam:N_methyl_2 - - - - - - - - - - - - N_methyl k59_364192_1 313628.LNTAR_21400 4.34e-12 72.0 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 3.2.1.4,3.2.1.73 ko:K01179,ko:K01216,ko:K21449 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko02000 1.B.40.2 GH5,GH9 - CBM_3,F5_F8_type_C,PKD,fn3 k59_337225_2 1082932.ATCR1_06741 4.61e-22 95.1 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria 1224|Proteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_296777_1 1122201.AUAZ01000007_gene3692 2.45e-09 62.0 28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,1S23F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_161896_1 697329.Rumal_0182 1.44e-10 63.5 COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,24A3M@186801|Clostridia,3WIR5@541000|Ruminococcaceae 186801|Clostridia F TIGRFAM deoxycytidine triphosphate deaminase dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - DCD,dUTPase k59_364197_1 1166130.H650_06830 1.01e-35 134.0 COG4695@1|root,COG4695@2|Bacteria,1PFTD@1224|Proteobacteria,1RTWZ@1236|Gammaproteobacteria,3X3J3@547|Enterobacter 1236|Gammaproteobacteria S Portal protein - - - - - - - - - - - - - k59_28299_3 1168059.KB899087_gene3476 1.64e-18 87.0 COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria,3EZ1J@335928|Xanthobacteraceae 28211|Alphaproteobacteria S metal-dependent phosphohydrolase HD MA20_42120 - - ko:K06952 - - - - ko00000 - - - HD,HD_3 k59_41716_2 203119.Cthe_0522 0.000176 43.5 COG2909@1|root,COG2909@2|Bacteria,1VMYN@1239|Firmicutes,25EDD@186801|Clostridia 186801|Clostridia K trisaccharide binding - - - - - - - - - - - - - k59_419108_2 172088.AUGA01000043_gene4912 3.2e-11 73.9 COG4385@1|root,COG4385@2|Bacteria,1RHFH@1224|Proteobacteria,2UA4Q@28211|Alphaproteobacteria,3K26R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Phage tail protein (Tail_P2_I) - - - - - - - - - - - - Tail_P2_I k59_270818_1 1692244.A0A0K1RLR5_9CIRC 9.77e-30 113.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_95580_2 1540097.A0A0A0YRN0_9CAUD 5.93e-276 781.0 4QF3C@10239|Viruses,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_95580_3 470.IX87_01950 1.53e-16 76.3 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1SA7C@1236|Gammaproteobacteria,3NSKU@468|Moraxellaceae 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_82206_2 948071.S4S2S9_9CAUD 1.96e-42 158.0 4QBYN@10239|Viruses,4QZT8@35237|dsDNA viruses no RNA stage,4QR5G@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_28531_3 68194.JNXR01000006_gene3478 9.06e-13 65.1 2DMIE@1|root,32RSG@2|Bacteria,2IQEH@201174|Actinobacteria 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA - - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_352347_1 1123319.AUBE01000024_gene2253 1.37e-42 176.0 COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria 201174|Actinobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon k59_136432_2 1460634.JCM19037_221 2.75e-07 57.8 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,4H9RF@91061|Bacilli 91061|Bacilli L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_1218_2 4792.ETI36607 5.1e-05 51.2 2CTQC@1|root,2RH2U@2759|Eukaryota,3QISM@4776|Peronosporales 4776|Peronosporales - - - - - - - - - - - - - - - k59_1218_3 948071.S4S2T1_9CAUD 4.3e-13 76.6 4QHPY@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QSXS@28883|Caudovirales,4QNJ2@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_297976_1 1136535.I6NVP1_9CAUD 4.02e-15 79.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_271042_2 1788442.A0A190WH98_9CIRC 1.7e-50 175.0 4QB6C@10239|Viruses,4QUKM@29258|ssDNA viruses 10239|Viruses J Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_338924_1 1121378.KB899701_gene2074 7.59e-49 196.0 COG5280@1|root,COG5280@2|Bacteria 2|Bacteria NT Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail,SLT k59_393589_1 691965.D4P7D6_9CAUD 4.05e-73 241.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_258924_1 1235793.C809_02225 2.14e-58 199.0 COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia 186801|Clostridia S Mu-like prophage protein gp29 - - - - - - - - - - - - - k59_177826_2 1408418.JNJH01000012_gene3580 2.22e-38 144.0 28N1N@1|root,2ZB7Q@2|Bacteria,1R86T@1224|Proteobacteria,2U0A6@28211|Alphaproteobacteria,2JRMI@204441|Rhodospirillales 204441|Rhodospirillales H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_16122_2 335659.S23_38620 2.83e-13 74.3 COG0175@1|root,COG4725@1|root,COG0175@2|Bacteria,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,3JXMZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70,ParBc k59_16305_1 105154.Q9MBU3_9VIRU 2.73e-10 62.4 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_110604_2 1265502.KB905977_gene528 2.55e-37 132.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,4AIQ3@80864|Comamonadaceae 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_327357_1 882.DVU_2871 2.31e-30 124.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,2MBC6@213115|Desulfovibrionales 28221|Deltaproteobacteria OU signal peptide peptidase SppA, 36K type - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_71361_1 596154.Alide2_2789 9.96e-40 148.0 2CC4J@1|root,2Z7W8@2|Bacteria,1R42M@1224|Proteobacteria,2VN58@28216|Betaproteobacteria,4ADD2@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_71361_3 398578.Daci_4125 2.61e-10 59.7 2C9JF@1|root,32RPD@2|Bacteria,1N8CG@1224|Proteobacteria,2VXEV@28216|Betaproteobacteria 28216|Betaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_43249_2 1692255.A0A0K1RL52_9CIRC 8.46e-92 282.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_367099_1 1215092.PA6_009_00600 7.46e-41 147.0 COG2887@1|root,COG2887@2|Bacteria,1R4U3@1224|Proteobacteria,1TBQN@1236|Gammaproteobacteria,1YIJR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_340886_1 421052.F945_02819 1.2e-51 173.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,3NKQ6@468|Moraxellaceae 1236|Gammaproteobacteria H GTP cyclohydrolase - - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_71364_1 1250232.JQNJ01000001_gene2906 3.54e-18 91.3 COG5283@1|root,COG5283@2|Bacteria,4NIZH@976|Bacteroidetes 976|Bacteroidetes D domain protein - - - - - - - - - - - - PhageMin_Tail k59_407617_1 1116232.AHBF01000036_gene5620 2.2e-28 119.0 COG0270@1|root,COG0270@2|Bacteria,2I8R8@201174|Actinobacteria 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_407617_2 1235803.C825_03383 3.34e-17 77.0 2ETIK@1|root,33M2E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_259174_5 145579.CAPSD_BPPHM 5.82e-99 317.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_340895_2 1185766.DL1_08470 2.09e-25 112.0 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,2UPJH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_380200_1 1313421.JHBV01000036_gene2445 3.04e-74 232.0 COG0602@1|root,COG0602@2|Bacteria 2|Bacteria H queuosine metabolic process queE GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 - R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14,Radical_SAM k59_380200_2 111105.HR09_07255 1.34e-22 90.9 COG0720@1|root,COG0720@2|Bacteria,4PIUG@976|Bacteroidetes,2FSF1@200643|Bacteroidia 976|Bacteroidetes H 6-pyruvoyl tetrahydrobiopterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_191452_1 1235835.C814_03161 7.31e-31 125.0 COG4974@1|root,COG4974@2|Bacteria,1TQXV@1239|Firmicutes,24884@186801|Clostridia,3WHE7@541000|Ruminococcaceae 186801|Clostridia L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_138457_2 1118057.CAGX01000043_gene505 3.04e-27 112.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,22GDX@1570339|Peptoniphilaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_30098_1 1090133.G8EYI7_9CAUD 7.48e-17 81.6 4QB4I@10239|Viruses,4QVFV@35237|dsDNA viruses no RNA stage,4QPKN@28883|Caudovirales,4QNBN@10744|Podoviridae 10744|Podoviridae S Pfam:GP3_package - - - - - - - - - - - - - k59_4380_1 278957.ABEA03000110_gene1319 2.55e-50 179.0 COG0270@1|root,COG0270@2|Bacteria,46XFY@74201|Verrucomicrobia,3K9VN@414999|Opitutae 414999|Opitutae L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_86484_1 365046.Rta_12630 4.02e-18 88.6 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs-related protein - - - - - - - - - - - - RHS,RHS_repeat k59_44861_2 1788439.A0A190WHD0_9CIRC 4.45e-15 82.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_180141_1 658187.LDG_6143 5.06e-14 79.0 COG0467@1|root,COG1119@1|root,COG0467@2|Bacteria,COG1119@2|Bacteria 2|Bacteria P ATPase activity - - - ko:K03546,ko:K06919,ko:K07452,ko:K08482,ko:K09384,ko:K10954 ko05110,map05110 - - - ko00000,ko00001,ko01000,ko02042,ko02048,ko03400 - - - AAA_11,AAA_12,AAA_25,DUF4011 k59_180141_2 60520.HR47_01195 1.74e-18 96.3 COG5545@1|root,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,4HCHZ@91061|Bacilli,3F4EZ@33958|Lactobacillaceae 91061|Bacilli S Virulence-associated protein E - - - - - - - - - - - - VirE k59_287426_2 1280696.ATVY01000002_gene3504 3.97e-07 55.5 arCOG09486@1|root,2ZC3Y@2|Bacteria,1URXK@1239|Firmicutes,259VA@186801|Clostridia,4C1AS@830|Butyrivibrio 186801|Clostridia S Glycosyl transferase family 11 - - - - - - - - - - - - Glyco_transf_11 k59_99348_1 1399774.JDWH01000036_gene4049 9.88e-09 68.2 COG0840@1|root,COG4733@1|root,COG0840@2|Bacteria,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,1S1E5@1236|Gammaproteobacteria,3X48S@547|Enterobacter 1236|Gammaproteobacteria NT Putative phage tail protein - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF1983,Phage-tail_3 k59_99348_2 573413.Spirs_2815 1.91e-10 63.5 2EJIR@1|root,33D9N@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Caudo_TAP,Phage_tail_APC k59_99348_17 926560.KE387029_gene76 5.59e-15 75.5 COG1694@1|root,COG1694@2|Bacteria 2|Bacteria FG Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG k59_99348_18 1538804.A0A088F6T3_9CAUD 5.46e-113 357.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_395313_6 1009370.ALO_12436 2.53e-18 95.5 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,4H3UZ@909932|Negativicutes 909932|Negativicutes S Phage terminase, large subunit - - - - - - - - - - - - Terminase_3,Terminase_3C k59_247712_1 1348114.OM33_08445 6.74e-52 169.0 2CPEB@1|root,32SIW@2|Bacteria,1MZE0@1224|Proteobacteria,1SARU@1236|Gammaproteobacteria,2Q4T5@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_219040_1 1204521.I7A8M7_9CAUD 6.13e-55 194.0 4QCZC@10239|Viruses,4QX3V@35237|dsDNA viruses no RNA stage,4QRH3@28883|Caudovirales,4QHVR@10662|Myoviridae 10662|Myoviridae S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_358972_1 411460.RUMTOR_01350 1.55e-05 49.3 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_358976_1 1312954.KI914854_gene2426 5.45e-33 140.0 COG0467@1|root,COG0467@2|Bacteria,2IGTH@201174|Actinobacteria 201174|Actinobacteria T AAA domain - - - - - - - - - - - - AAA_25 k59_370581_1 1304888.ATWF01000001_gene2300 1.4e-14 82.0 COG0305@1|root,COG0305@2|Bacteria,2GERT@200930|Deferribacteres 200930|Deferribacteres L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_370581_2 1225805.J7KBV5_9CAUD 3.38e-08 56.2 4QAX8@10239|Viruses,4QVB1@35237|dsDNA viruses no RNA stage,4QPHH@28883|Caudovirales,4QKTJ@10699|Siphoviridae 10699|Siphoviridae S calcium ion binding - - - - - - - - - - - - - k59_114061_2 349521.HCH_05652 3.03e-58 194.0 COG5449@1|root,COG5449@2|Bacteria,1MXK2@1224|Proteobacteria,1S5T3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_114061_3 1121935.AQXX01000096_gene2520 5.96e-94 305.0 COG4733@1|root,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,1RRUV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_411756_1 1235659.S4T941_9CAUD 1.66e-11 68.2 4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_127137_2 1313421.JHBV01000023_gene5090 2.88e-68 215.0 COG0338@1|root,COG0338@2|Bacteria,4P04I@976|Bacteroidetes 976|Bacteroidetes L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_76958_1 1618247.A0A0C5IMK7_9CIRC 9.59e-10 64.7 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_88824_1 946483.Cenrod_2391 4.52e-07 57.4 COG0438@1|root,COG0438@2|Bacteria,1RI6Q@1224|Proteobacteria,2VZM1@28216|Betaproteobacteria,4AGYE@80864|Comamonadaceae 28216|Betaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_345638_1 316407.85675220 1.66e-33 124.0 COG0524@1|root,COG0524@2|Bacteria,1PDS9@1224|Proteobacteria,1RQE5@1236|Gammaproteobacteria,3XNQU@561|Escherichia 1236|Gammaproteobacteria G belongs to the carbohydrate kinase PfkB family yegV GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 - - - - - - - - - - PfkB k59_345638_2 316407.85675219 5.64e-131 378.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,1RMPE@1236|Gammaproteobacteria,3XP4M@561|Escherichia 1236|Gammaproteobacteria O hydrolase activity yegU - - - - - - - - - - - ADP_ribosyl_GH k59_263710_2 1122201.AUAZ01000017_gene2960 1.84e-76 245.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_195128_1 717785.HYPMC_1228 1.97e-14 72.4 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_236105_1 1788444.A0A190WHB9_9CIRC 8.65e-37 132.0 4QASI@10239|Viruses,4QUM7@29258|ssDNA viruses 10239|Viruses L Geminivirus coat protein/nuclear export factor BR1 family - GO:0005575,GO:0018995,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0042025,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_347638_1 43354.JOIJ01000017_gene1311 2.66e-14 77.8 COG3409@1|root,COG3409@2|Bacteria,2GR1Q@201174|Actinobacteria,4DYAX@85010|Pseudonocardiales 201174|Actinobacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - CHAP,LysM,PG_binding_1 k59_147187_1 329254.Q2NPD3_9CAUD 4.8e-21 91.7 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_103328_1 478749.BRYFOR_08524 2.47e-13 69.3 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Terminase_1 k59_103328_2 478749.BRYFOR_08522 1.94e-61 207.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_331868_1 110663.KI911558_gene684 8.07e-14 74.3 COG0223@1|root,COG0223@2|Bacteria,1FZXC@1117|Cyanobacteria,1GYDF@1129|Synechococcus 1117|Cyanobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_331868_2 172045.KS04_13445 2.04e-12 67.8 COG0242@1|root,COG0242@2|Bacteria,4NKS9@976|Bacteroidetes,1I1S1@117743|Flavobacteriia,34S60@308865|Elizabethkingia 976|Bacteroidetes J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_221660_1 888052.HMPREF9006_1916 8.9e-14 84.0 COG3378@1|root,COG5545@1|root,COG3378@2|Bacteria,COG5545@2|Bacteria,2H1DT@201174|Actinobacteria,4D45K@85005|Actinomycetales 201174|Actinobacteria S cog cog3378 - - - ko:K06919 - - - - ko00000 - - - D5_N,DUF3854,Pox_D5,PriCT_1,Prim-Pol k59_62525_1 1234888.K0A2J2_9VIRU 2.33e-53 184.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_321829_2 1188795.K7ZMK0_9CAUD 3.56e-32 129.0 4QE1R@10239|Viruses,4R08Y@35237|dsDNA viruses no RNA stage,4QUAF@28883|Caudovirales,4QNMU@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_251432_1 1429046.RR21198_2833 1.08e-05 50.4 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_31 k59_105317_1 1465751.W8QE57_9VIRU 1.34e-56 187.0 4QC2G@10239|Viruses,4QV3V@35237|dsDNA viruses no RNA stage 10239|Viruses S Ribonucleotide reductase, small chain - - - - - - - - - - - - - k59_64402_1 146922.JOFU01000008_gene3000 4.51e-16 75.5 COG5005@1|root,COG5005@2|Bacteria,2GTWW@201174|Actinobacteria 201174|Actinobacteria S Phage virion morphogenesis - - - - - - - - - - - - - k59_38391_1 176652.443R_IIV6 2.52e-45 170.0 4QGYA@10239|Viruses,4QVUN@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_159878_2 502025.Hoch_4030 1.48e-12 73.9 COG3119@1|root,COG3119@2|Bacteria,1QZHU@1224|Proteobacteria,42PUM@68525|delta/epsilon subdivisions,2X7T5@28221|Deltaproteobacteria,2Z00V@29|Myxococcales 28221|Deltaproteobacteria P Sulfatase - - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - Cu-binding_MopE,Sulfatase k59_131765_1 1589733.A0A0C5AMW6_9CAUD 1.12e-35 134.0 4QCS3@10239|Viruses,4QU2E@28883|Caudovirales,4QKJF@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_415601_1 1618238.A0A0C5I2G8_9CIRC 3.59e-43 154.0 4QASI@10239|Viruses,4QUM7@29258|ssDNA viruses 10239|Viruses L Geminivirus coat protein/nuclear export factor BR1 family - GO:0005575,GO:0018995,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0042025,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217 - - - - - - - - - - - k59_117977_1 1114964.L485_09930 1.12e-17 85.5 COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2U773@28211|Alphaproteobacteria,2K1IN@204457|Sphingomonadales 204457|Sphingomonadales O Prolyl 4-hydroxylase alpha subunit homologues. - - 1.14.11.2 ko:K00472 ko00330,ko01100,map00330,map01100 - R01252 RC00478 ko00000,ko00001,ko01000 - - - 2OG-FeII_Oxy_3 k59_51464_1 479434.Sthe_1622 2.67e-21 98.6 COG0747@1|root,COG0747@2|Bacteria 2|Bacteria E dipeptide transport - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_223733_3 411460.RUMTOR_01352 4.95e-50 163.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_223733_4 626887.J057_01785 8.24e-44 159.0 2DCM2@1|root,32TZV@2|Bacteria,1NAGE@1224|Proteobacteria,1SMRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_268152_1 1122997.AUDD01000007_gene815 9.9e-63 209.0 COG0553@1|root,COG0553@2|Bacteria,2H20C@201174|Actinobacteria,4DTBP@85009|Propionibacteriales 201174|Actinobacteria KL DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_253441_2 216142.LT40_08970 3.73e-46 157.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S99W@1236|Gammaproteobacteria 1236|Gammaproteobacteria G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_24841_1 3885.XP_007158542.1 5.37e-06 56.6 COG0464@1|root,KOG0737@2759|Eukaryota,37IX2@33090|Viridiplantae,3GC4V@35493|Streptophyta,4JNMN@91835|fabids 35493|Streptophyta O Holliday junction DNA helicase ruvB N-terminus - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0008104,GO:0008144,GO:0008150,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017038,GO:0017076,GO:0017111,GO:0019867,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0045041,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:1901265,GO:1901363,GO:1990542 - - - - - - - - - - AAA k59_279666_1 1122201.AUAZ01000010_gene2520 3.84e-69 223.0 29UKS@1|root,30FY7@2|Bacteria,1RGKW@1224|Proteobacteria,1SKMS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_279666_6 1121440.AUMA01000002_gene2147 1.15e-22 101.0 COG4627@1|root,COG4627@2|Bacteria,1N2HA@1224|Proteobacteria 1224|Proteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Methyltransf_11 k59_279666_8 1082931.KKY_760 5.18e-06 57.4 COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2TSSY@28211|Alphaproteobacteria,3N6AU@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Phage major capsid protein gp36 - - - - - - - - - - - Phage_capsid k59_199812_1 1397699.JNIS01000001_gene2482 4.12e-05 52.0 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity pfbA - - ko:K13925 ko05100,map05100 - - - ko00000,ko00001 - - - Beta_helix,CW_binding_1,Pectate_lyase_3,YSIRK_signal k59_188643_1 563192.HMPREF0179_00372 4.95e-32 132.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,43AGK@68525|delta/epsilon subdivisions,2WJNQ@28221|Deltaproteobacteria,2MASS@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_120754_2 927658.AJUM01000034_gene336 2.68e-31 115.0 COG3772@1|root,COG3772@2|Bacteria,4NVJ5@976|Bacteroidetes,2FYU8@200643|Bacteroidia 976|Bacteroidetes G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_188654_2 1540097.A0A0A0YPY2_9CAUD 1.21e-19 87.8 4QGGR@10239|Viruses,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_430505_2 1692252.A0A0K1RL35_9CIRC 4.6e-95 290.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_120783_1 1535422.ND16A_2055 3.46e-09 64.3 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,2Q6D0@267889|Colwelliaceae 1236|Gammaproteobacteria M Bacterial sugar transferase wcaJ GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046377,GO:0071704,GO:0071944,GO:0089702,GO:1901135,GO:1901137,GO:1901576 - ko:K03606 ko05111,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3 k59_120799_2 272623.L76848 1.47e-29 109.0 COG1694@1|root,COG1694@2|Bacteria,1VIQA@1239|Firmicutes,4HSHR@91061|Bacilli,1YCGE@1357|Lactococcus 91061|Bacilli S MazG nucleotide pyrophosphohydrolase domain - - - - - - - - - - - - MazG k59_188678_4 68219.JNXI01000001_gene6110 6.26e-08 56.6 2BTCI@1|root,32NIA@2|Bacteria,2IC2R@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_376767_1 556269.ACDQ01000016_gene505 8.9e-31 127.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,4724B@75682|Oxalobacteraceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_338361_1 1107311.Q767_15695 5e-06 58.5 COG2304@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1IJ8A@117743|Flavobacteriia,2P0KQ@237|Flavobacterium 976|Bacteroidetes M Pkd domain containing protein - - - - - - - - - - - - CHU_C,Gal_Lectin,HYR,Laminin_G_3,PKD,SprB,TSP_3 k59_338361_2 398512.JQKC01000017_gene3068 2.26e-05 46.6 COG3507@1|root,COG4733@1|root,COG3507@2|Bacteria,COG4733@2|Bacteria,1UYQE@1239|Firmicutes,24C16@186801|Clostridia,3WI7H@541000|Ruminococcaceae 186801|Clostridia G Parallel beta-helix repeats - - - - - - - - - - - - CBM_6,Dockerin_1,Laminin_G_3 k59_418958_2 105154.Q9MBU6_9VIRU 6.99e-120 362.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_324842_3 1231057.AMGD01000045_gene610 8.59e-48 164.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli,26EDZ@186818|Planococcaceae 91061|Bacilli L Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_297653_1 882082.SaccyDRAFT_4646 3.5e-16 84.0 2CHG1@1|root,32YZS@2|Bacteria,2IRMN@201174|Actinobacteria,4E7K6@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_297653_2 351627.Csac_2602 1.59e-45 169.0 COG3723@1|root,COG3723@2|Bacteria,1V3B6@1239|Firmicutes,24HHQ@186801|Clostridia,42HHM@68295|Thermoanaerobacterales 186801|Clostridia L recombination protein Bet bet - - - - - - - - - - - RecT k59_297653_3 1429793.W0LNP3_9CAUD 2.98e-06 56.2 4QBP3@10239|Viruses,4QVAZ@35237|dsDNA viruses no RNA stage,4QPEQ@28883|Caudovirales,4QM06@10699|Siphoviridae 10699|Siphoviridae S PDDEXK-like domain of unknown function (DUF3799) - - - - - - - - - - - - - k59_81982_1 1188241.UDIV_3230 5.36e-07 59.3 COG0210@1|root,COG0210@2|Bacteria,3WT08@544448|Tenericutes 544448|Tenericutes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_162848_1 1287488.HMPREF0671_04205 3.68e-17 78.2 COG1694@1|root,COG1694@2|Bacteria,4P4XM@976|Bacteroidetes,2FY7H@200643|Bacteroidia 976|Bacteroidetes S MazG nucleotide pyrophosphohydrolase domain - - - - - - - - - - - - MazG k59_324843_1 634956.Geoth_1293 2.45e-07 57.4 COG4974@1|root,COG4974@2|Bacteria,1UXHS@1239|Firmicutes,4I2W9@91061|Bacilli,1WHKI@129337|Geobacillus 91061|Bacilli L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_integrase k59_352134_1 693746.OBV_43170 1.19e-17 87.8 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia 186801|Clostridia L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_136183_1 509191.AEDB02000020_gene3260 2.44e-16 84.7 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,3WHWY@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_109004_1 665956.HMPREF1032_00686 5.84e-71 240.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,3WN92@541000|Ruminococcaceae 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_191369_5 352165.HMPREF7215_0593 1.95e-10 73.9 COG3941@1|root,COG5281@1|root,COG3941@2|Bacteria,COG5281@2|Bacteria 2|Bacteria D sister chromatid segregation - - - - - - - - - - - - Tape_meas_lam_C k59_272126_3 321846.PS417_10005 3.71e-13 70.5 2EPEW@1|root,33H1I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_36,Phage_rep_O k59_367012_1 472175.EL18_02118 1.01e-27 111.0 2A5SG@1|root,30UHK@2|Bacteria,1Q0JJ@1224|Proteobacteria,2UZWA@28211|Alphaproteobacteria,43QJP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_314329_3 1304275.C41B8_05368 8.21e-82 270.0 28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_124096_1 1121289.JHVL01000007_gene2770 1.54e-17 84.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_205904_1 113395.AXAI01000002_gene5455 0.000262 50.8 COG4675@1|root,COG4675@2|Bacteria,1R7VJ@1224|Proteobacteria,2V8US@28211|Alphaproteobacteria,3JUWZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_110663_1 688270.Celal_2387 1.21e-06 61.6 COG3210@1|root,COG3266@1|root,COG3468@1|root,COG4733@1|root,COG5644@1|root,COG3210@2|Bacteria,COG3266@2|Bacteria,COG3468@2|Bacteria,COG4733@2|Bacteria,COG5644@2|Bacteria,4PKI0@976|Bacteroidetes,1HYWF@117743|Flavobacteriia,1F9Y8@104264|Cellulophaga 976|Bacteroidetes U PFAM Collagen triple helix repeat (20 copies) - - - - - - - - - - - - Collagen k59_205909_1 439235.Dalk_1643 9e-22 92.4 COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MI2C@213118|Desulfobacterales 28221|Deltaproteobacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Radical_SAM k59_205909_2 944481.JAFP01000001_gene1173 3.11e-26 106.0 COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2M737@213113|Desulfurellales 28221|Deltaproteobacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Radical_SAM k59_138550_1 644968.DFW101_3522 7.87e-68 222.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,42QKN@68525|delta/epsilon subdivisions,2WK3R@28221|Deltaproteobacteria,2MA6M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_166040_2 1406780.U5PWH9_9CAUD 5.64e-15 77.0 4QBY0@10239|Viruses,4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_125099_2 608538.HTH_0548 4.22e-54 184.0 2A75B@1|root,30W16@2|Bacteria,2G5D4@200783|Aquificae 200783|Aquificae S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_328876_1 1233488.S4T7F1_9CAUD 4.49e-17 85.5 4QF9T@10239|Viruses,4QXU6@35237|dsDNA viruses no RNA stage,4QQMJ@28883|Caudovirales,4QNEI@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_356053_8 997829.HMPREF1121_01465 9.55e-108 350.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity rtpR - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC k59_4115_1 31535.Q9MC50_BPD3 4.19e-46 159.0 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QKR7@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_287145_4 1385658.U5KNR1_9VIRU 1.12e-50 177.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_166054_1 1204521.I7A8M4_9CAUD 5.08e-54 181.0 4QCW5@10239|Viruses,4QWI1@35237|dsDNA viruses no RNA stage,4QQVP@28883|Caudovirales,4QHUS@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_98998_1 1121405.dsmv_2583 6.29e-09 64.7 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,42XCR@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_342847_1 1128421.JAGA01000002_gene516 1.94e-30 118.0 COG1351@1|root,COG1351@2|Bacteria,2NPQ2@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - HNH,Thy1 k59_395135_1 1304885.AUEY01000060_gene2393 1.38e-10 58.9 2E653@1|root,330TW@2|Bacteria,1NEKH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_421766_1 1609634.A0A0C5AFV4_9VIRU 4.4e-103 319.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_192822_1 305700.B447_04998 4.29e-143 414.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,2KZJK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_17848_1 691965.D4P7E6_9CAUD 4.41e-23 104.0 4QAK6@10239|Viruses,4R01K@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_4133_4 269796.Rru_A0271 1.2e-21 92.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,2JPKI@204441|Rhodospirillales 204441|Rhodospirillales H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_368497_1 443144.GM21_3566 4.85e-25 110.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,43SUM@69541|Desulfuromonadales 28221|Deltaproteobacteria C pyridine nucleotide-disulphide oxidoreductase dimerisation region lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_301247_1 1237149.C900_05366 6.3e-08 56.2 COG3740@1|root,COG3740@2|Bacteria,4NDXV@976|Bacteroidetes,47V54@768503|Cytophagia 976|Bacteroidetes S Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_249262_1 1788455.A0A190WHF5_9CIRC 2.74e-06 55.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_76518_1 212035.DNMK_MIMIV 2.06e-07 55.1 4QG7P@10239|Viruses,4QUU1@35237|dsDNA viruses no RNA stage 10239|Viruses S kinase activity - - - - - - - - - - - - - k59_358945_2 407392.A0MN56_9CAUD 1.44e-29 111.0 4QE7X@10239|Viruses,4QVF0@35237|dsDNA viruses no RNA stage,4QPUM@28883|Caudovirales,4QI2F@10662|Myoviridae 10662|Myoviridae S Cytidine and deoxycytidylate deaminase zinc-binding region - - - - - - - - - - - - - k59_303181_1 1248917.ANFX01000012_gene1858 5.67e-07 50.1 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2UG3A@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_358949_2 1618257.A0A0C5IBI9_9CIRC 2.73e-07 57.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_423636_1 5691.EAN80450 5.34e-63 222.0 COG0459@1|root,KOG0356@2759|Eukaryota,3XS95@5653|Kinetoplastida 5653|Kinetoplastida O Belongs to the chaperonin (HSP60) family - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_76532_1 265729.GS18_0205840 5.33e-10 68.6 2EYIP@1|root,33RSF@2|Bacteria,1VSNU@1239|Firmicutes,4HUJ1@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_76532_2 548479.HMPREF0573_11262 2.77e-30 115.0 2E2AR@1|root,32XG5@2|Bacteria 2|Bacteria S PFAM Pathogenesis-related transcriptional factor and ERF - - - - - - - - - - - - AP2,HNH_3 k59_101556_1 395495.Lcho_0484 5.7e-29 119.0 COG2227@1|root,COG2520@1|root,COG2227@2|Bacteria,COG2520@2|Bacteria 2|Bacteria J tRNA (guanine(37)-N(1))-methyltransferase activity - - - - - - - - - - - - Glycos_transf_2,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_25 k59_101556_2 768066.HELO_2115 1.63e-36 130.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria 1224|Proteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_411795_1 232721.Ajs_0930 1.14e-24 106.0 2E8E5@1|root,332SK@2|Bacteria,1QXJ1@1224|Proteobacteria,2VX3U@28216|Betaproteobacteria,4AFIH@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_20483_1 446471.Xcel_2527 1.29e-34 142.0 COG2340@1|root,COG4932@1|root,COG2340@2|Bacteria,COG4932@2|Bacteria,2GXWA@201174|Actinobacteria 201174|Actinobacteria M Cysteine-rich secretory protein family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - B_lectin,CarboxypepD_reg,Peptidase_M23,SASA k59_114104_1 1028307.EAE_08850 3.78e-19 89.4 28H9R@1|root,2Z7MD@2|Bacteria,1MVTR@1224|Proteobacteria,1RMPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF932 k59_88881_1 103372.F4WQ49 2.51e-18 91.3 COG3119@1|root,KOG3731@2759|Eukaryota,38E91@33154|Opisthokonta,3BCUU@33208|Metazoa,3D1EQ@33213|Bilateria,41V1N@6656|Arthropoda,3SJ7M@50557|Insecta,46KQ8@7399|Hymenoptera 33208|Metazoa G Sulfatase GNS GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0006022,GO:0006026,GO:0006027,GO:0006082,GO:0006790,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008449,GO:0008484,GO:0009056,GO:0009057,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0030203,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042339,GO:0042340,GO:0042582,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044422,GO:0044424,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901681,GO:1903510,GO:1904813 3.1.6.14 ko:K01137 ko00531,ko01100,ko04142,map00531,map01100,map04142 M00078,M00079 R07808,R07819 - ko00000,ko00001,ko00002,ko01000 - - - Sulfatase k59_234692_1 1051675.G0YQJ0_9CAUD 1.37e-61 207.0 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_62636_2 1121468.AUBR01000104_gene3117 2.03e-41 160.0 COG0863@1|root,COG0863@2|Bacteria,1TR56@1239|Firmicutes,248NR@186801|Clostridia 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family cfr9IM - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_62636_7 1242864.D187_008748 7.96e-54 185.0 COG0338@1|root,COG0338@2|Bacteria,1Q9YJ@1224|Proteobacteria,438CP@68525|delta/epsilon subdivisions,2X1WK@28221|Deltaproteobacteria,2YWK0@29|Myxococcales 28221|Deltaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase - - - - - - - - - - - - MethyltransfD12 k59_197009_1 1333998.M2A_3378 6.07e-23 102.0 COG3391@1|root,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,4BRUB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_372363_1 869662.M4PR87_9CAUD 4.4e-36 137.0 4QASW@10239|Viruses,4QVP9@35237|dsDNA viruses no RNA stage,4QRA5@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_8722_1 1266925.JHVX01000006_gene2075 2.05e-08 63.5 COG4733@1|root,COG4733@2|Bacteria,1PMY6@1224|Proteobacteria,2VNMV@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_322275_1 994479.GL877878_gene3316 5.33e-30 127.0 COG0305@1|root,COG1066@1|root,COG0305@2|Bacteria,COG1066@2|Bacteria,2I8H0@201174|Actinobacteria 201174|Actinobacteria L AAA domain - - - - - - - - - - - - AAA_25,DnaB k59_236397_1 1340534.S4X0W4_9CAUD 9.33e-13 69.3 4QFB4@10239|Viruses,4QZ8P@35237|dsDNA viruses no RNA stage,4QSGK@28883|Caudovirales,4QMVQ@10699|Siphoviridae 10699|Siphoviridae S viral capsid - GO:0005575,GO:0019012,GO:0019028,GO:0044423 - - - - - - - - - - - k59_197248_6 1341151.ASZU01000008_gene1531 4.4e-54 191.0 COG1783@1|root,COG1783@2|Bacteria,1VK0H@1239|Firmicutes,4HQ2H@91061|Bacilli 91061|Bacilli S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_277681_1 1618236.A0A0C5IB23_9CIRC 5.4e-50 176.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_332123_1 391625.PPSIR1_34462 4.52e-13 73.9 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2YTT3@29|Myxococcales 28221|Deltaproteobacteria M penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_322294_1 585531.HMPREF0063_10202 4.18e-07 57.0 COG1475@1|root,COG2189@1|root,COG1475@2|Bacteria,COG2189@2|Bacteria,2H100@201174|Actinobacteria,4DWCI@85009|Propionibacteriales 201174|Actinobacteria L ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_266038_2 521460.Athe_2414 8.33e-05 45.1 2EKMA@1|root,33EB3@2|Bacteria,1VPK8@1239|Firmicutes,24UF5@186801|Clostridia,42J0D@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - k59_253314_1 411460.RUMTOR_01356 3.1e-36 140.0 28JED@1|root,2Z98K@2|Bacteria,1TW1U@1239|Firmicutes,24CFD@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - GerE k59_385629_1 1283071.R9R5B2_9CAUD 1.29e-68 236.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_385629_3 572544.Ilyop_0371 5.7e-41 141.0 COG0756@1|root,COG0756@2|Bacteria,37A2G@32066|Fusobacteria 32066|Fusobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_385629_5 1051675.G0YQF1_9CAUD 3.42e-42 157.0 4QW35@35237|dsDNA viruses no RNA stage,4QQ4Q@28883|Caudovirales,4QNNN@10744|Podoviridae 10744|Podoviridae S UvrD-like helicase C-terminal domain - - - - - - - - - - - - - k59_10506_2 1089121.G8I4P9_9CAUD 1.63e-15 87.4 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_223648_2 1280666.ATVS01000020_gene252 1.12e-14 74.3 COG0773@1|root,COG0773@2|Bacteria,1VTVI@1239|Firmicutes,24Y9A@186801|Clostridia,4C1ZN@830|Butyrivibrio 186801|Clostridia M Mur ligase family, catalytic domain - - - - - - - - - - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_294713_1 883.DvMF_1638 4.42e-20 92.0 2EBZ0@1|root,335Y9@2|Bacteria,1NF45@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_64564_1 517418.Ctha_1696 6.41e-36 141.0 COG1198@1|root,COG1198@2|Bacteria,1FDNM@1090|Chlorobi 1090|Chlorobi L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Helicase_C,ResIII k59_199669_1 359.CN09_09375 1.16e-39 143.0 COG0863@1|root,COG0863@2|Bacteria,1PCS4@1224|Proteobacteria,2VDM8@28211|Alphaproteobacteria,4BIRX@82115|Rhizobiaceae 28211|Alphaproteobacteria H DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_199669_2 219305.MCAG_03853 5.12e-21 92.8 2EUW1@1|root,33070@2|Bacteria,2HWIJ@201174|Actinobacteria,4DIWR@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_427932_3 1112217.PPL19_22942 0.000419 51.6 COG4675@1|root,COG4675@2|Bacteria,1RDJW@1224|Proteobacteria,1S415@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tail collar domain protein - - - - - - - - - - - - Collar,Phage_fiber_2 k59_226565_1 1556290.A0A0A0RL61_9CAUD 1.2e-51 179.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_256211_1 867902.Ornrh_1183 9.2e-11 70.1 COG1196@1|root,COG1196@2|Bacteria,4NUKP@976|Bacteroidetes,1I4MA@117743|Flavobacteriia 976|Bacteroidetes D nuclear chromosome segregation - - - - - - - - - - - - - k59_256212_1 444860.E3SJ76_9CAUD 5.72e-43 153.0 4QCFA@10239|Viruses,4QUPF@35237|dsDNA viruses no RNA stage,4QQD7@28883|Caudovirales,4QIYX@10662|Myoviridae 10662|Myoviridae S coenzyme binding - - - - - - - - - - - - - k59_335975_2 592031.GCWU000322_00934 3.05e-08 57.0 COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,25UT6@186806|Eubacteriaceae 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_430654_2 1692252.A0A0K1RL35_9CIRC 6.84e-81 254.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_336659_1 1986029.Q9MBM3_9VIRU 5.24e-56 189.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_240404_1 391612.CY0110_05944 1.06e-22 101.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G35U@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - DUF4118,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_430658_1 350688.Clos_1826 3.93e-17 87.4 28KEB@1|root,2ZA0K@2|Bacteria,1V14E@1239|Firmicutes,25K6P@186801|Clostridia,36PDM@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_430659_2 1618247.A0A0C5IMK7_9CIRC 1.52e-11 68.2 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_227657_2 1404245.CGLY_09415 9.98e-20 87.8 COG4186@1|root,COG4186@2|Bacteria,2IRS9@201174|Actinobacteria,22MZH@1653|Corynebacteriaceae 201174|Actinobacteria S phosphoesterase or phosphohydrolase - - - - - - - - - - - - Metallophos,Metallophos_2 k59_388510_1 525244.HMPREF0023_2096 1.28e-09 65.1 2D784@1|root,32TNH@2|Bacteria,1N098@1224|Proteobacteria,1SDM3@1236|Gammaproteobacteria,3NNDQ@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_336733_2 1041138.KB890258_gene2807 1.46e-08 57.8 2DE5J@1|root,2ZKKF@2|Bacteria,1NHAR@1224|Proteobacteria,2U4YI@28211|Alphaproteobacteria,4BP0X@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_365038_4 1396418.BATQ01000041_gene6240 4.14e-18 90.9 COG4675@1|root,COG4675@2|Bacteria,46X85@74201|Verrucomicrobia,2IUYY@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_405606_4 311424.DhcVS_916 2.77e-15 73.6 COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi,34DBK@301297|Dehalococcoidia 301297|Dehalococcoidia L Single-strand binding protein family ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_149308_1 563008.HMPREF0665_02448 1.8e-21 100.0 28P8B@1|root,2ZC2B@2|Bacteria,4NMJJ@976|Bacteroidetes,2FTMF@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_176006_4 203122.Sde_1925 3.51e-38 155.0 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,1RSQN@1236|Gammaproteobacteria,465EQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Helicase conserved C-terminal domain VPA1393 - - - - - - - - - - - Helicase_C,ResIII k59_149314_1 1231185.BAMP01000032_gene806 1.12e-13 75.5 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2TUGQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria OU periplasmic serine proteases (ClpP class) - - - - - - - - - - - - Peptidase_S49 k59_203666_17 1038859.AXAU01000001_gene3739 1.6e-51 189.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3JRJJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_216600_1 1122137.AQXF01000002_gene217 9.57e-05 48.5 COG3064@1|root,COG3064@2|Bacteria,1NQ5T@1224|Proteobacteria,2UK7G@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - PTR k59_55393_1 1122201.AUAZ01000017_gene2950 6.47e-73 231.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria,46BED@72275|Alteromonadaceae 1236|Gammaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_257139_2 391587.KAOT1_16558 3.44e-51 167.0 COG0791@1|root,COG0791@2|Bacteria,4NPFE@976|Bacteroidetes,1I29F@117743|Flavobacteriia 976|Bacteroidetes M CHAP domain - - - - - - - - - - - - CHAP k59_203667_1 243274.THEMA_02295 2.56e-07 53.5 COG0162@1|root,COG0162@2|Bacteria,2GCKH@200918|Thermotogae 200918|Thermotogae J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iLJ478.TM0478 S4,tRNA-synt_1b k59_203667_2 345341.KUTG_01907 8.47e-61 196.0 COG0500@1|root,COG2226@2|Bacteria,2IGXK@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_378812_2 365659.smi_0447 3.29e-12 63.5 29Z0H@1|root,30KXM@2|Bacteria,1U4T9@1239|Firmicutes,4IPFS@91061|Bacilli,2TQFS@28037|Streptococcus mitis 91061|Bacilli - - - - - - - - - - - - - - - k59_109799_1 992406.RIA_0232 9.58e-16 77.8 2BZ0F@1|root,32XZX@2|Bacteria,4NV66@976|Bacteroidetes,1I5HI@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_258331_2 31535.Q9MC50_BPD3 8.69e-41 145.0 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QKR7@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_42498_2 646529.Desaci_2496 5.4e-07 51.6 COG3369@1|root,COG3369@2|Bacteria,1TV60@1239|Firmicutes,24D1A@186801|Clostridia,264MH@186807|Peptococcaceae 186801|Clostridia S CDGSH-type zinc finger. Function unknown. - - - - - - - - - - - - Fer4_19,zf-CDGSH k59_204742_3 585425.KR52_03475 9.2e-51 171.0 29CPA@1|root,2ZZMJ@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_313148_2 1276257.SSABA_v1c00290 2.08e-10 67.0 COG0692@1|root,COG0692@2|Bacteria,3WTJA@544448|Tenericutes 544448|Tenericutes L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_150523_1 1548905.A0A0A1IX16_9CAUD 1.17e-16 78.6 4QBTT@10239|Viruses,4QQUU@28883|Caudovirales,4QKWB@10699|Siphoviridae 10699|Siphoviridae S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - - k59_150523_2 335283.Neut_1457 2.02e-21 86.3 2CJX7@1|root,32W32@2|Bacteria,1N82M@1224|Proteobacteria,2VY34@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_366231_2 391615.ABSJ01000003_gene462 1.44e-21 99.4 COG5301@1|root,COG5301@2|Bacteria,1MWNN@1224|Proteobacteria,1RR74@1236|Gammaproteobacteria,1JAD9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Phage tail-collar fibre protein H - - - - - - - - - - - Collar,DUF3751,Phage_fiber_2 k59_163605_2 402626.Rpic_2326 1.54e-23 104.0 COG3355@1|root,COG3355@2|Bacteria,1N3ME@1224|Proteobacteria,2W4B4@28216|Betaproteobacteria,1KAF2@119060|Burkholderiaceae 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - - k59_83300_1 1500890.JQNL01000001_gene3314 6.69e-18 96.7 COG0845@1|root,COG4733@1|root,COG0845@2|Bacteria,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,1RNFD@1236|Gammaproteobacteria,1XABA@135614|Xanthomonadales 135614|Xanthomonadales M Phage-related protein, tail component - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_83300_2 187303.BN69_1660 7.4e-12 65.9 COG0791@1|root,COG0791@2|Bacteria,1N732@1224|Proteobacteria,2UH6X@28211|Alphaproteobacteria,36YQR@31993|Methylocystaceae 28211|Alphaproteobacteria M NlpC/P60 family - - - - - - - - - - - - NLPC_P60 k59_83300_4 1449351.RISW2_21770 1.81e-11 76.3 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - PhageMin_Tail,TMP_2,Tape_meas_lam_C k59_204751_1 439375.Oant_1781 5.26e-18 84.0 28NEI@1|root,2ZBH3@2|Bacteria,1NPBX@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_393006_6 416870.llmg_0244 1.06e-20 93.6 COG0692@1|root,COG0692@2|Bacteria,1TPSN@1239|Firmicutes,4HBTR@91061|Bacilli,1YC5E@1357|Lactococcus 91061|Bacilli L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_393006_7 926550.CLDAP_05560 1.11e-12 72.4 COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi 200795|Chloroflexi S PFAM glutamine amidotransferase class-I - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_393006_8 1327990.S0A3X2_9CAUD 5e-35 134.0 4QE8X@10239|Viruses,4QYGD@35237|dsDNA viruses no RNA stage,4QRJF@28883|Caudovirales,4QNB2@10744|Podoviridae 10744|Podoviridae S Phage phiEco32-like COOH.NH2 ligase-type 2 - - - - - - - - - - - - - k59_393006_9 658659.HMPREF0983_03328 2.48e-06 51.2 COG2105@1|root,COG2105@2|Bacteria,1VARY@1239|Firmicutes,3VR9T@526524|Erysipelotrichia 526524|Erysipelotrichia S Gamma-glutamyl cyclotransferase, AIG2-like - - - - - - - - - - - - GGACT k59_72664_7 1209989.TepiRe1_1126 4.54e-15 79.0 2C9JF@1|root,32RPD@2|Bacteria,1VC16@1239|Firmicutes,24RAH@186801|Clostridia,42IR8@68295|Thermoanaerobacterales 186801|Clostridia S ERF superfamily - - - - - - - - - - - - ERF k59_72664_14 2340.JV46_03620 1.46e-27 122.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_72664_21 102107.XP_008232555.1 3.37e-07 58.2 KOG1565@1|root,KOG1565@2759|Eukaryota,37Y4V@33090|Viridiplantae,3GNE5@35493|Streptophyta,4JSZC@91835|fabids 35493|Streptophyta OW Zinc-dependent metalloprotease - - - - - - - - - - - - Peptidase_M10 k59_72664_25 1329516.JPST01000018_gene2640 3.09e-25 107.0 2EAUG@1|root,334W4@2|Bacteria,1VX7Q@1239|Firmicutes 1239|Firmicutes S ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_31184_1 1449126.JQKL01000003_gene1695 3.16e-34 130.0 28W6R@1|root,2ZI7D@2|Bacteria,1V1MZ@1239|Firmicutes,24FAN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_44059_1 765869.BDW_02245 0.000535 43.5 COG3291@1|root,COG3291@2|Bacteria,1RCXG@1224|Proteobacteria,42SKT@68525|delta/epsilon subdivisions,2X89X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Mycoplasma protein of unknown function, DUF285 - - - - - - - - - - - - DUF285 k59_342194_2 1217705.F900_01055 0.000125 47.0 2DYV8@1|root,32V63@2|Bacteria,1QNWV@1224|Proteobacteria,1ST2X@1236|Gammaproteobacteria,3NNP1@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_152213_2 268748.Q58N23_BPPRP 8.75e-13 73.9 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_152213_3 1122201.AUAZ01000017_gene2962 7.01e-14 73.9 COG4675@1|root,COG4675@2|Bacteria 2|Bacteria M tail collar domain protein - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Collar,Phage_fiber_2 k59_140165_1 582899.Hden_2876 8.66e-05 50.8 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,3N6ET@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L Elongator protein 3, MiaB family, Radical SAM MA20_42330 - - - - - - - - - - - Radical_SAM k59_85725_1 1395516.PMO01_03050 1.16e-06 56.6 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_124693_2 1120792.JAFV01000001_gene3544 5.21e-83 277.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,36Z9P@31993|Methylocystaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_124693_3 1038860.AXAP01000015_gene2003 3.98e-31 126.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_124693_4 388051.AUFE01000035_gene4020 2.47e-87 280.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_124693_6 69328.PVLB_20830 9.02e-27 119.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_124693_21 1161401.ASJA01000008_gene1673 5.55e-05 56.6 COG1196@1|root,COG5281@1|root,COG1196@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2U3WK@28211|Alphaproteobacteria 28211|Alphaproteobacteria D tape measure protein - - - - - - - - - - - - Peptidase_M15_4,Tape_meas_lam_C k59_19432_4 467481.B0VK09_9CAUD 0.000802 42.0 4QB0W@10239|Viruses,4QZQH@35237|dsDNA viruses no RNA stage,4QQW9@28883|Caudovirales,4QN19@10699|Siphoviridae 10699|Siphoviridae S Protein of unknown function (DUF1064) - - - - - - - - - - - - - k59_75529_6 1410620.SHLA_72c000290 3.37e-47 166.0 28H9R@1|root,2Z7MD@2|Bacteria,1MVTR@1224|Proteobacteria,2U0NB@28211|Alphaproteobacteria,4B9XP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_410859_1 1385658.U5KPZ6_9VIRU 3.46e-189 546.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_288750_1 765911.Thivi_3544 7.39e-11 70.5 COG3391@1|root,COG3979@1|root,COG3391@2|Bacteria,COG3979@2|Bacteria 2|Bacteria S chitin catabolic process chiA GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005623,GO:0008843,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.14,3.2.1.17 ko:K01183,ko:K03933,ko:K13381,ko:K21449 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000,ko02000 1.B.40.2 AA10,CBM15,CBM73,GH18 - CBM_5_12,Cytochrome_C554,DUF5011,LPMO_10 k59_274902_1 1123279.ATUS01000005_gene3105 4.95e-45 153.0 2DNB5@1|root,32WIW@2|Bacteria,1N0BM@1224|Proteobacteria,1S8UT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage HK97-gp10, putative tail-component - - - - - - - - - - - - HK97-gp10_like k59_274902_2 1280949.HAD_08480 2.86e-18 81.6 COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria,2U2NZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_100943_2 1234888.K0A2J2_9VIRU 4.81e-41 150.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_411143_1 1089439.KB902270_gene2567 0.0003 50.8 2EFTG@1|root,339JJ@2|Bacteria,1P5FK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_100948_1 1283299.AUKG01000001_gene1539 7.58e-23 100.0 COG0863@1|root,COG0863@2|Bacteria,2IM4X@201174|Actinobacteria 201174|Actinobacteria L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_274915_1 691965.D4P7D6_9CAUD 3.88e-80 261.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_383787_4 1209072.ALBT01000028_gene1291 9.15e-17 86.3 COG0438@1|root,COG1216@1|root,COG3551@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG3551@2|Bacteria,1PG4U@1224|Proteobacteria,1RXHA@1236|Gammaproteobacteria,1FIHI@10|Cellvibrio 1236|Gammaproteobacteria M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_383787_5 1121373.KB903621_gene1808 4.33e-11 68.2 COG0500@1|root,COG2226@2|Bacteria,4P4Z8@976|Bacteroidetes 976|Bacteroidetes Q Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_347131_1 1121870.AUAA01000026_gene617 1.04e-60 200.0 COG0476@1|root,COG0476@2|Bacteria,4NHIM@976|Bacteroidetes,1HX9Q@117743|Flavobacteriia 976|Bacteroidetes H Thiamine biosynthesis protein ThiF - - - - - - - - - - - - ThiF k59_347131_2 483216.BACEGG_00412 2.05e-23 99.0 28M9D@1|root,2ZANB@2|Bacteria,4NIRS@976|Bacteroidetes,2FQ6N@200643|Bacteroidia,4ANTB@815|Bacteroidaceae 976|Bacteroidetes S PRTRC system protein B - - - - - - - - - - - - Prok-E2_D k59_169528_2 1618247.A0A0C5IMK7_9CIRC 0.00012 48.9 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_62225_3 2711.XP_006478118.1 3.88e-05 48.9 2CM9Z@1|root,2QPRE@2759|Eukaryota,37M51@33090|Viridiplantae,3GCPS@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_383987_1 691965.D4P7D6_9CAUD 1.18e-146 441.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_321435_1 490913.C4NTE9_9CAUD 1.31e-122 374.0 4QF3C@10239|Viruses,4QWIA@35237|dsDNA viruses no RNA stage,4QU4U@28883|Caudovirales,4QNNQ@10744|Podoviridae 10744|Podoviridae S host cell wall - - - - - - - - - - - - - k59_22029_1 1121087.AUCK01000002_gene2480 4.8e-48 167.0 COG4397@1|root,COG4397@2|Bacteria 2|Bacteria S Mu-like prophage major head subunit gpT - - - - - - - - - - - - Mu-like_gpT,Peptidase_S78 k59_250954_1 1114179.I2FLT8_9CAUD 1.21e-80 269.0 4QAUF@10239|Viruses,4QWIQ@35237|dsDNA viruses no RNA stage,4QUFS@28883|Caudovirales,4QNVK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_128918_1 1328029.S0A548_9CAUD 9.13e-82 263.0 4QB9T@10239|Viruses,4R0FI@35237|dsDNA viruses no RNA stage,4QQR9@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_291072_2 1206732.BAGD01000103_gene4535 2.31e-13 68.9 2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4G252@85025|Nocardiaceae 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whiB2 - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_425270_1 1280692.AUJL01000009_gene2976 8.81e-09 61.6 COG3561@1|root,COG3646@1|root,COG3561@2|Bacteria,COG3646@2|Bacteria,1VFZC@1239|Firmicutes,24AEZ@186801|Clostridia,36JYN@31979|Clostridiaceae 186801|Clostridia K Phage regulatory protein Rha (Phage_pRha) rha - - - - - - - - - - - ANT,ORF6C,Phage_pRha k59_196540_1 1192034.CAP_8843 3.3e-72 231.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2YTSX@29|Myxococcales 28221|Deltaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_128922_2 755732.Fluta_2976 4.51e-13 67.4 COG3409@1|root,COG3409@2|Bacteria,4NTD1@976|Bacteroidetes 976|Bacteroidetes M Peptidoglycan binding domain protein - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_291076_2 756883.Halar_1012 3.03e-10 66.6 COG1199@1|root,arCOG00770@2157|Archaea 2157|Archaea KL COG1199 Rad3-related DNA helicases - - - - - - - - - - - - DEAD_2,Helicase_C_2,ResIII k59_221471_1 1122182.KB903835_gene4297 5.08e-16 82.0 2EB9A@1|root,3359T@2|Bacteria,2INFV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_321450_1 484018.BACPLE_01149 1.22e-07 59.3 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,2FNFH@200643|Bacteroidia,4AMQJ@815|Bacteroidaceae 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_38079_3 1556290.A0A0A0RM00_9CAUD 2.12e-41 153.0 4QAXQ@10239|Viruses,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_64119_1 471856.Jden_2324 7.72e-64 211.0 2EDV8@1|root,337QD@2|Bacteria,2GTXK@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_64119_3 1463858.JOHR01000031_gene5569 9.58e-31 140.0 COG1511@1|root,COG1842@1|root,COG3953@1|root,COG5412@1|root,COG1511@2|Bacteria,COG1842@2|Bacteria,COG3953@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria 201174|Actinobacteria KT Phage tail tape measure protein TP901 - - - - - - - - - - - - NLPC_P60,SLT k59_64119_7 1440053.JOEI01000012_gene4338 0.000425 45.4 COG5005@1|root,COG5005@2|Bacteria,2I84B@201174|Actinobacteria 201174|Actinobacteria S Phage virion morphogenesis - - - - - - - - - - - - HK97-gp10_like k59_131438_1 439235.Dalk_3546 1.45e-26 113.0 COG3941@1|root,COG3941@2|Bacteria,1MZWI@1224|Proteobacteria,42RRK@68525|delta/epsilon subdivisions,2WT71@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Mu-like prophage protein - - - - - - - - - - - - - k59_333116_1 1316739.R4JMY7_9CAUD 6.77e-17 85.1 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_333116_2 1316739.R4JMY7_9CAUD 1.61e-13 75.1 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_279053_1 333138.LQ50_04395 2.52e-40 149.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli,1ZB0Z@1386|Bacillus 91061|Bacilli KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_172085_1 386456.JQKN01000002_gene2593 5.08e-11 62.4 COG1562@1|root,arCOG02936@2157|Archaea,2XTG2@28890|Euryarchaeota 28890|Euryarchaeota I Phytoene squalene synthetase crtB - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_172085_2 1218103.CIN01S_07_01800 8.13e-19 89.0 COG1233@1|root,COG1233@2|Bacteria,4NF7K@976|Bacteroidetes,1HWP8@117743|Flavobacteriia,3ZPWB@59732|Chryseobacterium 976|Bacteroidetes Q Phytoene dehydrogenase crtI - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_267937_2 1556290.A0A0A0RL96_9CAUD 2.02e-95 300.0 4QGMJ@10239|Viruses,4QSYG@28883|Caudovirales,4QM5B@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_185505_1 330214.NIDE3489 9.87e-57 190.0 COG4243@1|root,COG4243@2|Bacteria 2|Bacteria S quinone binding - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - - k59_335609_1 305700.B447_10643 1.24e-19 86.3 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VW90@28216|Betaproteobacteria 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_107766_2 556269.ACDQ01000003_gene1355 3.74e-39 135.0 COG0791@1|root,COG0791@2|Bacteria,1NA3R@1224|Proteobacteria,2VXXX@28216|Betaproteobacteria 28216|Betaproteobacteria M to Bacteriophage D3 Orf25 SWALL Q9MC96 (EMBL AF165214) (135 aa) fasta scores E() 0.00047, 30.46 id in 128 aa - - - - - - - - - - - - NLPC_P60 k59_107766_3 556269.ACDQ01000003_gene1354 1.73e-33 123.0 2C095@1|root,32VKM@2|Bacteria,1N0Y9@1224|Proteobacteria,2VUZF@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_376111_1 1423807.BACO01000036_gene1075 1.51e-05 52.8 2DCYU@1|root,32U0J@2|Bacteria,1VC2I@1239|Firmicutes,4IRUY@91061|Bacilli,3FBQ8@33958|Lactobacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_67107_1 691965.D4P7E6_9CAUD 6.91e-17 88.6 4QAK6@10239|Viruses,4R01K@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_107771_1 755731.Clo1100_1145 4.5e-79 246.0 COG0863@1|root,COG0863@2|Bacteria,1V0ZF@1239|Firmicutes,24CQV@186801|Clostridia,36J76@31979|Clostridiaceae 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_13233_1 745088.D4N4H8_9CAUD 1.45e-07 59.3 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_255721_1 1123312.KB904575_gene72 3.26e-50 177.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli 91061|Bacilli L SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_377215_1 1122201.AUAZ01000017_gene2960 6.21e-67 220.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_377215_2 1051675.G0YQJ1_9CAUD 6.27e-63 204.0 4QGM6@10239|Viruses,4QYNV@35237|dsDNA viruses no RNA stage,4QRH4@28883|Caudovirales,4QP0P@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_404275_2 1132026.I6NQ46_9CAUD 1.95e-05 55.8 4QBSJ@10239|Viruses,4QXH4@35237|dsDNA viruses no RNA stage,4QPFJ@28883|Caudovirales,4QKUK@10699|Siphoviridae 10699|Siphoviridae S DNA primase activity - - - - - - - - - - - - - k59_404276_1 400668.Mmwyl1_4219 1.94e-25 109.0 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,1RSQN@1236|Gammaproteobacteria,1XJ09@135619|Oceanospirillales 135619|Oceanospirillales L Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C,ResIII k59_240079_1 1100720.ALKN01000018_gene1739 9.61e-55 186.0 28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,2VNFP@28216|Betaproteobacteria,4A9TU@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_430600_2 1379715.S5TMW6_9CIRC 4.49e-43 155.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_430602_1 1692253.A0A0K1RLM4_9CIRC 0.000569 42.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_430602_2 1692256.A0A0K1RL85_9CIRC 2.27e-77 244.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_14509_3 1313421.JHBV01000155_gene784 8e-38 136.0 28MC2@1|root,2ZAQD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_270819_5 1286632.P278_28060 6.95e-14 70.9 2DMPB@1|root,32SV8@2|Bacteria,4NSG4@976|Bacteroidetes,1I3FJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_230268_1 653733.Selin_1634 1.1e-28 120.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0000287,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004536,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006284,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0017108,GO:0018130,GO:0019438,GO:0019439,GO:0022616,GO:0030312,GO:0030955,GO:0031420,GO:0033554,GO:0033567,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0048256,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576 2.7.7.7 ko:K01146,ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1071_1 1298867.AUES01000037_gene750 1.3e-16 85.5 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2TUXC@28211|Alphaproteobacteria,3K1NA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L helicase superfamily c-terminal domain - - - ko:K19789 - - - - ko00000,ko03400 - - - DUF3427,HIT,Helicase_C,PLDc_2,ResIII,UPF0547 k59_136166_1 316407.85676525 5.62e-138 403.0 COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,1RMFP@1236|Gammaproteobacteria,3XMAI@561|Escherichia 1236|Gammaproteobacteria G Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity treF GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245 Trehalase k59_149600_1 980584.AFPB01000080_gene2579 1.47e-140 433.0 COG2273@1|root,COG3401@1|root,COG2273@2|Bacteria,COG3401@2|Bacteria,4PNM1@976|Bacteroidetes,1IK8V@117743|Flavobacteriia 976|Bacteroidetes G Hydrolase Family 16 - - - - - - - - - - - - - k59_14518_2 145579.REP_BPPHM 6.58e-13 76.3 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_14518_3 1234888.K0A2J2_9VIRU 1.02e-89 290.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_55631_1 691965.D4P7D6_9CAUD 2.07e-85 286.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_55631_4 478749.BRYFOR_08518 2.01e-58 191.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_55631_6 428125.CLOLEP_01417 6.5e-26 105.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,3WMXK@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_311887_3 395019.Bmul_3835 1.76e-15 80.1 COG0338@1|root,COG0338@2|Bacteria,1QZWQ@1224|Proteobacteria 1224|Proteobacteria L DNA N-6-adenine-methyltransferase (Dam) - - - - - - - - - - - - Dam k59_136168_2 266779.Meso_0235 8.61e-06 49.3 2AKMC@1|root,31BDU@2|Bacteria,1Q78H@1224|Proteobacteria,2UT82@28211|Alphaproteobacteria 28211|Alphaproteobacteria S HNH endonuclease - - - - - - - - - - - - HNH_3 k59_365431_2 1155718.KB891853_gene3576 2.68e-08 58.5 2EPW3@1|root,33HGM@2|Bacteria,2IRK1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_271017_1 388051.AUFE01000035_gene4020 2.63e-08 60.5 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_299337_1 1157634.KB912977_gene192 4.88e-37 144.0 2C9AC@1|root,2Z7TR@2|Bacteria,2I07F@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_353941_2 1005994.GTGU_01492 7.03e-25 101.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,1SCZN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - AP2,HNH_3 k59_97106_4 118173.KB235914_gene2132 2.06e-06 52.8 COG1876@1|root,COG3409@1|root,COG3926@1|root,COG1876@2|Bacteria,COG3409@2|Bacteria,COG3926@2|Bacteria,1G4XP@1117|Cyanobacteria,1HAVP@1150|Oscillatoriales 1117|Cyanobacteria M Peptidase M15B M15C, D,D-carboxypeptidase VanY endolysins - - - - - - - - - - - - PG_binding_1,VanY k59_71097_6 649743.HMPREF0972_01707 6.61e-15 70.5 2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4D68S@85005|Actinomycetales 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whmD - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_71097_11 1172188.KB911820_gene2873 5.07e-44 166.0 COG0305@1|root,COG0305@2|Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_25,DnaB,DnaB_C k59_245616_1 457429.ABJI02000737_gene388 1.07e-21 101.0 COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria 201174|Actinobacteria Q ABC transporter (Permease) - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_368374_3 202954.BBNK01000034_gene3794 2.55e-25 100.0 2A3Q7@1|root,30S7S@2|Bacteria,1NP2K@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_165947_1 1676184.A0A186YBN5_9CIRC 4.5e-06 55.5 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_179722_3 697282.Mettu_3802 5.03e-36 132.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria,1XFIU@135618|Methylococcales 135618|Methylococcales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_124971_5 472759.Nhal_1282 1.47e-26 100.0 2DSGM@1|root,33G20@2|Bacteria,1NM38@1224|Proteobacteria,1SI90@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_124971_7 574087.Acear_1218 1.52e-44 151.0 arCOG06669@1|root,2ZC1E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_99077_2 573.JG24_08580 2.61e-06 50.4 COG1403@1|root,COG1403@2|Bacteria,1NARE@1224|Proteobacteria,1S6GV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH k59_342961_1 1692252.A0A0K1RL35_9CIRC 2.83e-44 159.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_368553_1 525257.HMPREF0204_12939 2.3e-07 54.7 2DRAR@1|root,33AZK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_369755_1 742740.HMPREF9474_02272 2.56e-118 355.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,222GA@1506553|Lachnoclostridium 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_369755_2 411460.RUMTOR_01348 6.45e-113 340.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_33788_1 556269.ACDQ01000003_gene1356 3.2e-27 114.0 COG4733@1|root,COG4733@2|Bacteria,1PG9M@1224|Proteobacteria,2W1MG@28216|Betaproteobacteria,4782D@75682|Oxalobacteraceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_396773_2 1501269.EW15_1879 8.86e-30 112.0 COG2947@1|root,COG2947@2|Bacteria,1G5R2@1117|Cyanobacteria,1MMCU@1212|Prochloraceae 1117|Cyanobacteria S Alternative locus ID - - - - - - - - - - - - EVE k59_396773_3 446468.Ndas_4500 1.59e-07 51.6 COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4EHHK@85012|Streptosporangiales 201174|Actinobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_274986_1 1788445.A0A190WHA3_9CIRC 4.69e-50 170.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_210115_1 1379715.S5TMW6_9CIRC 5.03e-06 50.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_411220_2 248742.XP_005649863.1 5.76e-25 106.0 COG0714@1|root,2R89P@2759|Eukaryota,37TBX@33090|Viridiplantae,34H6G@3041|Chlorophyta 3041|Chlorophyta S AAA domain (dynein-related subfamily) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5 k59_210121_1 1454004.AW11_00908 2.27e-25 107.0 COG4643@1|root,COG4643@2|Bacteria,1MW9E@1224|Proteobacteria,2VKFM@28216|Betaproteobacteria 28216|Betaproteobacteria S P4 alpha zinc-binding domain protein - - - ko:K06919 - - - - ko00000 - - - Prim_Zn_Ribbon,Toprim_3 k59_88138_1 333138.LQ50_21145 1.92e-09 60.5 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,1ZPV5@1386|Bacillus 91061|Bacilli O Belongs to the peptidase S8 family aprE GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030193,GO:0030195,GO:0032101,GO:0032102,GO:0042730,GO:0043170,GO:0044238,GO:0048519,GO:0048583,GO:0048585,GO:0050789,GO:0050818,GO:0050819,GO:0050878,GO:0051239,GO:0051241,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070011,GO:0071704,GO:0080134,GO:0140096,GO:1900046,GO:1900047,GO:1901564,GO:1903034,GO:1903035 3.4.21.62 ko:K01342 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Inhibitor_I9,Peptidase_S8,SLH k59_88138_14 243230.DR_0488 3.35e-11 64.7 COG3584@1|root,COG3584@2|Bacteria,1WKHT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S 3D domain protein - - - - - - - - - - - - - k59_113593_8 742740.HMPREF9474_02314 1.4e-39 144.0 2A0KC@1|root,30NQJ@2|Bacteria,1V3K4@1239|Firmicutes,24HYK@186801|Clostridia,222N6@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_113593_10 411460.RUMTOR_01340 2.15e-26 103.0 2ECB3@1|root,3369E@2|Bacteria,1VEV9@1239|Firmicutes,24R69@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_5846_1 1379709.S5TMV0_9CIRC 1.74e-20 95.5 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_19782_6 1122622.ATWJ01000008_gene2692 0.000208 45.8 2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4FHDI@85021|Intrasporangiaceae 201174|Actinobacteria S Lsr2 lsr - - - - - - - - - - - Lsr2 k59_276793_4 1356854.N007_08485 1.25e-24 107.0 COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,4HC5V@91061|Bacilli 91061|Bacilli L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_90120_1 1122182.KB903835_gene4297 1.51e-17 85.9 2EB9A@1|root,3359T@2|Bacteria,2INFV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_90120_2 1479238.JQMZ01000001_gene2201 3.14e-75 244.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2U64S@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_250621_1 1141140.K4FCD2_9CAUD 1.16e-05 53.5 4QAQ9@10239|Viruses,4QUYQ@35237|dsDNA viruses no RNA stage,4QPTV@28883|Caudovirales,4QKRS@10699|Siphoviridae 10699|Siphoviridae S Putative phage tail protein - GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044406,GO:0044419,GO:0044650,GO:0051704 - - - - - - - - - - - k59_146167_1 946235.CAER01000065_gene2464 5.31e-91 289.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli 91061|Bacilli L DNA polymerase polA_2 - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_424929_2 563192.HMPREF0179_03420 2.66e-10 60.8 2EHVE@1|root,32QS6@2|Bacteria,1P3YB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_371551_1 391038.Bphy_1861 5.92e-41 147.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2VUEJ@28216|Betaproteobacteria,1K8Z8@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_347043_1 76869.PputGB1_1389 1.48e-14 78.6 COG0438@1|root,COG2227@1|root,COG4641@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria,COG4641@2|Bacteria,1R8HV@1224|Proteobacteria,1S3XH@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Glycosyl transferases group 1 - - - - - - - - - - - - DUF3880,Glyco_trans_1_2 k59_90134_1 428125.CLOLEP_01411 1.34e-57 194.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,3WNJZ@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_321023_5 318464.IO99_00635 1.65e-07 63.5 COG5281@1|root,COG5281@2|Bacteria,1TPWF@1239|Firmicutes,24A8R@186801|Clostridia,36GW3@31979|Clostridiaceae 186801|Clostridia S tape measure - - - - - - - - - - - - - k59_331508_8 1120792.JAFV01000001_gene592 1.27e-75 256.0 COG3740@1|root,COG3740@2|Bacteria 2|Bacteria OU Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_331508_9 644968.DFW101_3522 2.54e-10 61.6 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,42QKN@68525|delta/epsilon subdivisions,2WK3R@28221|Deltaproteobacteria,2MA6M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_102984_1 330214.NIDE4304 8.38e-64 202.0 COG3023@1|root,COG3023@2|Bacteria 2|Bacteria V N-Acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K11066,ko:K12287 - - - - ko00000,ko01000,ko01011,ko02044 - - - Amidase_2 k59_146518_1 1004785.AMBLS11_12290 1.79e-07 61.6 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1R7KR@1224|Proteobacteria,1S1E5@1236|Gammaproteobacteria 1236|Gammaproteobacteria D COG4733 Phage-related protein, tail component - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF1983,Phage-tail_3 k59_7888_1 1121926.AXWO01000004_gene1187 2.18e-29 116.0 2B815@1|root,3218Y@2|Bacteria,2H57E@201174|Actinobacteria 201174|Actinobacteria S Rad52/22 family double-strand break repair protein - - - - - - - - - - - - Rad52_Rad22 k59_79074_1 44056.XP_009033993.1 1.32e-26 113.0 2EGF7@1|root,2SMDP@2759|Eukaryota 2759|Eukaryota S Glycosyl transferases group 1 - - - - - - - - - - - - - k59_321279_1 257310.BB0485 2.42e-31 111.0 294HZ@1|root,2ZRXM@2|Bacteria,1P8SB@1224|Proteobacteria,2WDBW@28216|Betaproteobacteria,3T8ED@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_37486_1 929704.Myrod_0674 2.43e-27 106.0 2DN1F@1|root,32UYC@2|Bacteria,4NUCU@976|Bacteroidetes,1I4IH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_266939_2 1009370.ALO_09559 4.55e-15 76.6 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,4H4BG@909932|Negativicutes 909932|Negativicutes S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP k59_323416_1 266779.Meso_0224 1.77e-49 170.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,43K78@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_385070_2 1157708.KB907450_gene5441 2.47e-08 58.9 COG5434@1|root,COG5434@2|Bacteria,1RCW1@1224|Proteobacteria,2W4G2@28216|Betaproteobacteria 28216|Betaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_104496_1 1449353.JQMQ01000005_gene4474 1.33e-21 96.3 COG4626@1|root,COG4626@2|Bacteria,2GNSB@201174|Actinobacteria 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_323418_1 172088.AUGA01000071_gene7569 3.66e-50 180.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_116905_3 140626.JHWB01000009_gene1075 2.4e-05 49.7 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_184870_2 1027273.GZ77_09015 3.34e-77 241.0 28HHC@1|root,2Z7T2@2|Bacteria,1PZ57@1224|Proteobacteria,1SRT1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - AAA_24 k59_171635_2 472759.Nhal_1137 5.35e-15 75.5 COG1403@1|root,COG1403@2|Bacteria,1N6FJ@1224|Proteobacteria 1224|Proteobacteria V HNH endonuclease - - - - - - - - - - - - - k59_117110_1 1168478.I6S6M4_9CAUD 1.7e-29 118.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QN7D@10699|Siphoviridae 10699|Siphoviridae S ATPase activity - - - - - - - - - - - - - k59_349487_1 938288.HG326225_gene1157 2.38e-15 80.1 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_293561_2 1234888.K0A2J2_9VIRU 6.53e-51 177.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_104731_4 1127696.HMPREF9134_00466 3.35e-06 50.8 COG1061@1|root,COG1061@2|Bacteria,4NECV@976|Bacteroidetes,2FN7J@200643|Bacteroidia 976|Bacteroidetes L Helicase C-terminal domain protein - - - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,QSregVF_b,ResIII k59_237148_1 1005058.UMN179_02395 4.38e-14 73.6 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,1RRQA@1236|Gammaproteobacteria,1Y889@135625|Pasteurellales 135625|Pasteurellales OU Belongs to the peptidase S14 family - - - - - - - - - - - - CLP_protease,Mu-like_gpT k59_159190_2 1121451.DESAM_22653 9.56e-42 151.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2WJBW@28221|Deltaproteobacteria,2M8NS@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM ATPase associated with various cellular activities - - - - - - - - - - - - AAA_3,AAA_5 k59_400317_1 314262.MED193_12633 4.95e-08 60.1 2EPTJ@1|root,33HE3@2|Bacteria,1NNYK@1224|Proteobacteria,2UWK5@28211|Alphaproteobacteria 2|Bacteria - - - - - - - - - - - - - - - k59_225232_1 1484157.PSNIH2_13405 1.45e-05 48.5 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,1SF0N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_254889_2 490913.C4NTC3_9CAUD 1.36e-12 65.9 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_174929_1 1279038.KB907338_gene1128 1.08e-69 230.0 COG0507@1|root,COG5362@1|root,COG0507@2|Bacteria,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2U236@28211|Alphaproteobacteria,2JUGR@204441|Rhodospirillales 204441|Rhodospirillales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_281607_1 1286093.C266_25815 6.19e-61 200.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,1K96C@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_417448_2 28229.ND2E_0020 4.22e-13 75.9 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,2Q72E@267889|Colwelliaceae 1236|Gammaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_375207_1 1535287.JP74_14770 1.8e-28 117.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,3N6FQ@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria D recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_12348_1 397290.C810_00429 0.000187 50.1 COG5280@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5412@2|Bacteria,1TPR1@1239|Firmicutes,25FD6@186801|Clostridia,27N6K@186928|unclassified Lachnospiraceae 186801|Clostridia S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_201819_1 742740.HMPREF9474_02303 1.53e-52 187.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,221YV@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_119450_2 691965.D4P7E5_9CAUD 2.54e-36 127.0 4QEVD@10239|Viruses,4QW84@35237|dsDNA viruses no RNA stage,4QQSX@28883|Caudovirales,4QMU4@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_119450_3 478749.BRYFOR_08513 5.16e-06 48.5 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Amidase_2,LysM,PG_binding_1 k59_386731_2 946362.XP_004994950.1 3.89e-19 94.0 COG5165@1|root,COG5648@1|root,KOG0381@2759|Eukaryota,KOG0526@2759|Eukaryota,38CT0@33154|Opisthokonta 33154|Opisthokonta B DNA replication SSRP1 GO:0000003,GO:0000228,GO:0000785,GO:0000790,GO:0000981,GO:0001672,GO:0001932,GO:0001933,GO:0002064,GO:0002065,GO:0002066,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005730,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006338,GO:0006342,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0007276,GO:0007281,GO:0007292,GO:0008023,GO:0008064,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009607,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010638,GO:0010646,GO:0016043,GO:0016070,GO:0016458,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0030154,GO:0030447,GO:0030466,GO:0030702,GO:0030707,GO:0030832,GO:0030833,GO:0030838,GO:0030855,GO:0031298,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0031399,GO:0031400,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032268,GO:0032269,GO:0032271,GO:0032273,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032774,GO:0032956,GO:0032970,GO:0032991,GO:0033036,GO:0033043,GO:0033044,GO:0033554,GO:0034613,GO:0034622,GO:0034641,GO:0034645,GO:0034654,GO:0034724,GO:0034728,GO:0035101,GO:0036170,GO:0036180,GO:0040007,GO:0040029,GO:0042325,GO:0042326,GO:0042594,GO:0043044,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043486,GO:0043596,GO:0043621,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044182,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044703,GO:0044877,GO:0045814,GO:0045892,GO:0045893,GO:0045898,GO:0045899,GO:0045934,GO:0045935,GO:0045936,GO:0045944,GO:0046483,GO:0048468,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051101,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051493,GO:0051495,GO:0051641,GO:0051704,GO:0051716,GO:0060255,GO:0060260,GO:0060261,GO:0060429,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0071103,GO:0071496,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090066,GO:0090304,GO:0097159,GO:0097659,GO:0110053,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901796,GO:1902275,GO:1902531,GO:1902679,GO:1902680,GO:1902903,GO:1902905,GO:1903506,GO:1903507,GO:1903508,GO:1990141,GO:2000112,GO:2000113,GO:2000142,GO:2000144,GO:2001141 - ko:K09272 - - - - ko00000,ko03000 - - - HMG_box,POB3_N,Rtt106,SSrecog k59_26401_1 742738.HMPREF9460_02499 4.91e-23 103.0 COG1061@1|root,COG3341@1|root,COG1061@2|Bacteria,COG3341@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia,269NJ@186813|unclassified Clostridiales 186801|Clostridia L helicase superfamily c-terminal domain - - - - - - - - - - - - HNH,Helicase_C,ResIII k59_187316_1 882.DVU_1515 8.42e-27 108.0 COG0270@1|root,COG0270@2|Bacteria,1PPPB@1224|Proteobacteria,43A4E@68525|delta/epsilon subdivisions,2WUDB@28221|Deltaproteobacteria,2MB1N@213115|Desulfovibrionales 28221|Deltaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_187316_2 227086.JGI_V11_66124 1.15e-14 77.8 COG0553@1|root,KOG1000@2759|Eukaryota 2759|Eukaryota L annealing helicase activity - - 3.6.4.12 ko:K14440 - - - - ko00000,ko01000,ko03036 - - - Helicase_C,SNF2_N k59_26403_1 176280.SE_2119 2.84e-34 137.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,4GXC6@90964|Staphylococcaceae 91061|Bacilli P P-type ATPase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_66225_1 216591.BCAS0523 1.66e-12 75.1 28H88@1|root,2Z7K7@2|Bacteria,1R5AY@1224|Proteobacteria,2VP4P@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - Phage_cap_E k59_417489_1 1120950.KB892797_gene2224 3.03e-06 57.8 COG3420@1|root,COG3420@2|Bacteria,2GN61@201174|Actinobacteria,4DT2V@85009|Propionibacteriales 201174|Actinobacteria P Chondroitinase B - - - - - - - - - - - - Chondroitinas_B k59_119469_1 1692253.A0A0K1RLM4_9CIRC 1.29e-18 87.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_12736_1 1144310.PMI07_002360 3.48e-07 56.6 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria,4BP2Q@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_202157_1 272942.RCAP_rcc00964 5.72e-25 121.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,1FD1T@1060|Rhodobacter 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_202157_3 1125863.JAFN01000001_gene3560 1.7e-30 115.0 2E5ZV@1|root,330P8@2|Bacteria,1NFRE@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_229859_1 1367847.JCM7686_2916 2.12e-14 85.9 COG4678@1|root,COG4678@2|Bacteria,1N51M@1224|Proteobacteria,2UC8H@28211|Alphaproteobacteria,2PWTF@265|Paracoccus 28211|Alphaproteobacteria G Muramidase (Phage lambda lysozyme) - - - - - - - - - - - - - k59_41291_2 701347.Entcl_1833 3.29e-06 49.3 COG0847@1|root,COG0847@2|Bacteria,1R9YS@1224|Proteobacteria,1S23K@1236|Gammaproteobacteria,3X29R@547|Enterobacter 1236|Gammaproteobacteria L 3' exoribonuclease, RNase T-like - - - ko:K10906 - - - - ko00000,ko01000,ko03400 - - - DUF5051,Exonuc_VIII k59_68200_5 1121440.AUMA01000012_gene1362 1.04e-123 373.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions,2WQN3@28221|Deltaproteobacteria,2M90K@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_405595_1 665956.HMPREF1032_00239 5.8e-05 51.6 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3WGRT@541000|Ruminococcaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_108592_1 1279017.AQYJ01000022_gene2771 1.86e-55 184.0 COG0270@1|root,COG0270@2|Bacteria,1NPQG@1224|Proteobacteria,1S07Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_108592_2 1038867.AXAY01000025_gene2083 3.94e-20 84.0 2BUGS@1|root,32PST@2|Bacteria,1Q8S2@1224|Proteobacteria,2UY1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_203575_1 485913.Krac_0474 2.39e-36 131.0 28HRJ@1|root,2Z7YZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_175832_1 202954.BBNK01000010_gene1410 3.15e-20 97.8 COG0741@1|root,COG1196@1|root,COG2911@1|root,COG0741@2|Bacteria,COG1196@2|Bacteria,COG2911@2|Bacteria,1QU6S@1224|Proteobacteria,1S7WY@1236|Gammaproteobacteria,3NKIY@468|Moraxellaceae 1236|Gammaproteobacteria D tail tape measure protein - - - - - - - - - - - - SLT,Tape_meas_lam_C k59_283893_3 1009370.ALO_09559 4.43e-15 75.1 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,4H4BG@909932|Negativicutes 909932|Negativicutes S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP k59_283893_4 883066.HMPREF9233_00128 4.18e-05 45.4 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4D33G@85005|Actinomycetales 201174|Actinobacteria L DNA-directed DNA polymerase dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_324509_1 441768.ACL_1247 3.15e-33 135.0 COG0459@1|root,COG0459@2|Bacteria,3WT2D@544448|Tenericutes 544448|Tenericutes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groEL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_418701_1 76114.ebA5486 5.32e-29 121.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2WGSR@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_135981_6 6669.EFX81388 0.000586 46.6 COG0526@1|root,KOG0190@2759|Eukaryota,38GTB@33154|Opisthokonta,3BC3B@33208|Metazoa,3CV6F@33213|Bilateria,41Y1D@6656|Arthropoda 33208|Metazoa O isomerase activity. It is involved in the biological process described with cell redox homeostasis - GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006457,GO:0006950,GO:0008150,GO:0009987,GO:0012505,GO:0016853,GO:0016860,GO:0016864,GO:0033554,GO:0034976,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0140096 5.3.4.1 ko:K08056,ko:K09582 ko04141,ko04612,ko04918,ko05110,map04141,map04612,map04918,map05110 - - - ko00000,ko00001,ko01000,ko03110,ko04131,ko04147 - - - Thioredoxin,Thioredoxin_6 k59_324853_1 489825.LYNGBM3L_19300 2.55e-239 665.0 COG4928@1|root,COG4928@2|Bacteria,1G4PP@1117|Cyanobacteria,1HF4Q@1150|Oscillatoriales 1117|Cyanobacteria S ATPase domain predominantly from Archaea - - - - - - - - - - - - ATPase_2 k59_324853_2 489825.LYNGBM3L_19310 1.01e-15 89.4 COG0457@1|root,COG0457@2|Bacteria,1G2UC@1117|Cyanobacteria,1HE3J@1150|Oscillatoriales 1117|Cyanobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_10 k59_324853_4 1333507.AUTQ01000151_gene399 0.000355 46.6 2C26I@1|root,33FR7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_324853_5 1170562.Cal6303_0680 4.52e-49 160.0 COG5499@1|root,COG5499@2|Bacteria,1G6YN@1117|Cyanobacteria,1HS5W@1161|Nostocales 1117|Cyanobacteria K transcription regulator containing HTH domain - - - ko:K18831 - - - - ko00000,ko02048,ko03000 - - - - k59_324853_6 28072.Nos7524_2775 5.15e-53 172.0 2E6GM@1|root,3313V@2|Bacteria,1G85C@1117|Cyanobacteria,1HMTF@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_324853_7 1121380.JNIW01000001_gene2807 1.12e-34 134.0 COG0286@1|root,COG0286@2|Bacteria,1WMIV@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_82025_1 1692242.A0A0K1RL37_9CIRC 3.49e-09 63.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_297705_2 1283300.ATXB01000001_gene196 1.62e-15 75.5 COG0358@1|root,COG0358@2|Bacteria,1N364@1224|Proteobacteria,1SDEX@1236|Gammaproteobacteria,1XGU9@135618|Methylococcales 135618|Methylococcales L DNA primase - - - - - - - - - - - - - k59_28171_1 691965.D4P7D6_9CAUD 2.27e-151 451.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_164157_1 742821.HMPREF9464_01834 2.96e-07 58.5 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_393571_1 67571.DPOL_BPAPS 4.02e-09 69.7 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_71063_1 1165094.RINTHH_3920 7.45e-56 185.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_354121_6 1166018.FAES_4065 6.25e-74 235.0 2C4HH@1|root,33XVS@2|Bacteria,4P2Z3@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_354121_7 1121286.AUMT01000013_gene2664 6.83e-07 51.2 COG1475@1|root,COG1475@2|Bacteria,4NVT4@976|Bacteroidetes 976|Bacteroidetes K DNA binding - - - - - - - - - - - - - k59_178009_2 716928.AJQT01000109_gene1217 1.66e-20 87.4 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_285886_1 1569209.BBPH01000023_gene178 6.45e-19 94.7 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TRFR@28211|Alphaproteobacteria,2PZ7Z@265|Paracoccus 28211|Alphaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_84165_1 1556290.A0A0A0RL61_9CAUD 2.04e-99 302.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_299451_1 73044.JNXP01000021_gene2484 6.79e-12 70.5 COG0305@1|root,COG0305@2|Bacteria,2IB86@201174|Actinobacteria 201174|Actinobacteria L DnaB-like helicase N terminal domain - - - - - - - - - - - - DnaB,DnaB_C k59_30065_2 205876.Q855N6_9CAUD 4.83e-32 122.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_407597_1 112098.XP_008607965.1 3.21e-35 138.0 COG1372@1|root,2QRRC@2759|Eukaryota 2759|Eukaryota L reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Ribonuc_red_lgC k59_380167_2 91604.ID47_02985 2.01e-22 97.8 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,2U1ZX@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - Terminase_6 k59_420544_5 292414.TM1040_0821 1.04e-06 58.2 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K12287 - - - - ko00000,ko02044 - - - DUF11,VCBS k59_420544_10 1122971.BAME01000119_gene6173 2.15e-12 79.0 COG1196@1|root,COG1196@2|Bacteria,4PMTY@976|Bacteroidetes,2FRJ0@200643|Bacteroidia 976|Bacteroidetes D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_178028_1 1380355.JNIJ01000010_gene1474 1.13e-11 70.9 2DXK1@1|root,345BZ@2|Bacteria,1NC0U@1224|Proteobacteria,2UGGZ@28211|Alphaproteobacteria,3K1EQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_164395_1 1556290.A0A0A0RSX5_9CAUD 1.54e-69 220.0 4QCAU@10239|Viruses,4QPJ6@28883|Caudovirales,4QKZJ@10699|Siphoviridae 10699|Siphoviridae S Pfam:GP88 - - - - - - - - - - - - - k59_16298_3 240292.Ava_4278 2.26e-33 119.0 2E0F1@1|root,32W1E@2|Bacteria,1G6H6@1117|Cyanobacteria,1HSDE@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_140963_1 1611039.A0A0C5C3Z3_9CIRC 6.23e-24 103.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_4269_1 329381.D9ICQ3_9CAUD 7.88e-12 71.2 4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses no RNA stage,4QPCE@28883|Caudovirales,4QI56@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_247468_4 1278971.AOGF01000034_gene1751 1.29e-08 57.4 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,1SF0N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_316666_2 1144325.PMI22_05747 1.67e-21 102.0 28KTY@1|root,2ZAAW@2|Bacteria,1R81A@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_301236_2 869210.Marky_0889 9.23e-36 139.0 COG0358@1|root,COG0358@2|Bacteria,1WIXS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_125278_1 1788454.A0A190WHE4_9CIRC 2.15e-51 177.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_140982_1 412965.COSY_0113 1.98e-39 147.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665 Pribosyl_synth,Pribosyltran_N k59_152979_2 1121382.JQKG01000015_gene1715 1.36e-99 305.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_261169_2 1379713.S5SYD9_9CIRC 7.5e-29 117.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_261169_3 1618236.A0A0C5I2F3_9CIRC 2.2e-39 146.0 4QGVY@10239|Viruses,4QUKN@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_166278_1 693444.D782_2483 2.18e-13 76.3 28KYW@1|root,2ZAE8@2|Bacteria,1MX3D@1224|Proteobacteria,1RQQR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4055) - - - - - - - - - - - - DUF4055 k59_73652_1 222449.REP_BGYMJ 1.65e-08 58.5 4QB6C@10239|Viruses,4QUKM@29258|ssDNA viruses 10239|Viruses J Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_77295_4 665956.HMPREF1032_00650 8.75e-116 347.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia,3WN6X@541000|Ruminococcaceae 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_345853_1 370438.PTH_2463 8.59e-06 51.6 28K97@1|root,2Z9WV@2|Bacteria,1TRTN@1239|Firmicutes,24B2J@186801|Clostridia,2664F@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_359548_3 1234888.K0A2J2_9VIRU 1.81e-91 288.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_411947_1 1340810.V5USF6_9CAUD 4.28e-10 69.7 4QGFJ@10239|Viruses,4QX7F@35237|dsDNA viruses no RNA stage,4QS96@28883|Caudovirales 28883|Caudovirales S Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - - k59_346268_1 1208323.B30_18602 5.55e-10 63.2 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2TVMB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM Gp37Gp68 family protein - - - - - - - - - - - - DUF5131 k59_304069_1 698761.RTCIAT899_CH12170 8.02e-74 254.0 COG2188@1|root,COG2188@2|Bacteria,1R5UI@1224|Proteobacteria,2U1BC@28211|Alphaproteobacteria,4BEIJ@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_276144_1 1041142.ATTP01000043_gene5288 1.33e-29 120.0 28QU5@1|root,2ZD9H@2|Bacteria,1RAU8@1224|Proteobacteria,2U2GD@28211|Alphaproteobacteria,4BC6R@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_61247_6 753084.F4YCI8_9CAUD 3.87e-09 58.2 4QUTY@35237|dsDNA viruses no RNA stage,4QM17@10699|Siphoviridae 10699|Siphoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_346280_1 1415780.JPOG01000001_gene1576 3.36e-19 90.5 COG3598@1|root,COG3598@2|Bacteria,1R4EA@1224|Proteobacteria,1RPWD@1236|Gammaproteobacteria 1236|Gammaproteobacteria L AAA domain - - - ko:K06919 - - - - ko00000 - - - AAA_25,Prim_Zn_Ribbon,Toprim_3 k59_127651_1 1385658.U5KPZ6_9VIRU 1.35e-91 287.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_256720_1 1327981.S0A1N4_9CAUD 3.04e-46 162.0 4QFGZ@10239|Viruses,4QY9R@35237|dsDNA viruses no RNA stage,4QPY9@28883|Caudovirales,4QMRF@10699|Siphoviridae 10699|Siphoviridae S Phage terminase large subunit - - - - - - - - - - - - - k59_337573_18 1206777.B195_08032 2.11e-41 142.0 COG0566@1|root,COG0566@2|Bacteria,1REIN@1224|Proteobacteria,1S48A@1236|Gammaproteobacteria,1Z4NE@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J SpoU rRNA Methylase family IV02_28330 - - - - - - - - - - - SpoU_methylase k59_324083_1 1618256.A0A0C5IM93_9CIRC 1.26e-53 186.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_189159_2 1304275.C41B8_05453 2.82e-114 373.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria 1224|Proteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_189159_6 1120973.AQXL01000105_gene2571 8.12e-09 56.6 COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,4HKEK@91061|Bacilli,27A2I@186823|Alicyclobacillaceae 91061|Bacilli O Chaperonin 10 Kd subunit groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_189159_10 1304275.C41B8_05408 1.7e-114 339.0 2DVPY@1|root,33WQ8@2|Bacteria,1N9VQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_189159_11 292.DM42_4055 3.44e-13 71.2 29F88@1|root,3025X@2|Bacteria,1NBJS@1224|Proteobacteria,2VWHK@28216|Betaproteobacteria,1KB80@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_189159_15 1465639.A0A060BS47_9CAUD 2.75e-11 69.7 4QB0J@10239|Viruses,4QZQE@35237|dsDNA viruses no RNA stage,4QQ11@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_189159_19 445692.E3SP37_9CAUD 1.3e-06 58.9 4QGAI@10239|Viruses,4QSN2@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_189159_20 1449346.JQMO01000003_gene5780 1.52e-08 56.2 COG2931@1|root,COG3534@1|root,COG2931@2|Bacteria,COG3534@2|Bacteria,2I945@201174|Actinobacteria 201174|Actinobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix,CBM_4_9,F5_F8_type_C,Laminin_G_3 k59_310846_1 272630.MexAM1_META1p3977 1.42e-88 278.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2U1ZE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_324090_1 1234888.K0A2J2_9VIRU 4.94e-40 146.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_202990_1 945021.TEH_18310 5.37e-21 92.4 2DR9Y@1|root,33AUY@2|Bacteria,1VEP1@1239|Firmicutes,4HIWW@91061|Bacilli,4B4BW@81852|Enterococcaceae 91061|Bacilli L NUMOD4 motif - - - - - - - - - - - - HNH_3,NUMOD4 k59_13891_1 69328.PVLB_20845 1.05e-99 307.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria 1224|Proteobacteria K Terminase - - - - - - - - - - - - Terminase_1 k59_15230_1 1244856.K4PY64_9CAUD 1.84e-82 268.0 4QF06@10239|Viruses,4QVMB@35237|dsDNA viruses no RNA stage,4QPRV@28883|Caudovirales,4QP2V@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_204387_1 90371.CY43_01695 1.6e-26 101.0 2CM4W@1|root,2ZKTU@2|Bacteria 2|Bacteria S Superinfection exclusion protein, bacteriophage P22 - - - - - - - - - - - - Gp17 k59_56163_11 66869.JNXG01000001_gene4057 2.32e-38 139.0 COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria,41CRY@629295|Streptomyces griseus group 201174|Actinobacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - - k59_56163_13 937777.Deipe_1570 1.11e-48 169.0 COG0338@1|root,COG0338@2|Bacteria 2|Bacteria L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12,Peptidase_S78_2 k59_28995_1 1500301.JQMF01000003_gene4211 3.37e-65 209.0 29X6Q@1|root,30IVV@2|Bacteria,1QZEA@1224|Proteobacteria,2TY78@28211|Alphaproteobacteria,4B9JD@82115|Rhizobiaceae 28211|Alphaproteobacteria S RecT family - - - - - - - - - - - - RecT k59_176994_2 1609634.A0A0C5AFV4_9VIRU 1.32e-34 130.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_42430_1 388467.A19Y_1076 4.12e-47 162.0 COG0863@1|root,COG0863@2|Bacteria,1G4CX@1117|Cyanobacteria,1HE0Q@1150|Oscillatoriales 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_244862_1 880073.Calab_1470 1.48e-51 171.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_29160_1 1618254.A0A0C5IBG4_9CIRC 6.45e-39 139.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_15465_3 1692244.A0A0K1RLR5_9CIRC 9.46e-15 75.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_57679_1 203124.Tery_2763 4.38e-16 85.1 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G15Q@1117|Cyanobacteria,1H7TC@1150|Oscillatoriales 1117|Cyanobacteria L tpr repeat - - - - - - - - - - - - CHAT k59_72198_1 1123237.Salmuc_02471 6.57e-09 67.8 COG1511@1|root,COG4678@1|root,COG5283@1|root,COG1511@2|Bacteria,COG4678@2|Bacteria,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2U1H4@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG5283 Phage-related tail protein - - - - - - - - - - - - Peptidase_M15_3,PhageMin_Tail k59_259798_2 1463853.JOHW01000037_gene6444 1.73e-12 69.3 2EGUB@1|root,33AKH@2|Bacteria,2I97J@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_206508_1 1415780.JPOG01000001_gene1751 1.4e-13 77.4 291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,1S4X6@1236|Gammaproteobacteria,1X9SN@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_341697_1 691965.D4P7L7_9CAUD 3.2e-50 184.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_341697_2 691965.D4P7L8_9CAUD 3.4e-20 83.6 4QCXV@10239|Viruses,4QWTS@35237|dsDNA viruses no RNA stage,4QSWS@28883|Caudovirales,4QN14@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_355195_1 1692252.A0A0K1RL35_9CIRC 2.46e-66 214.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_408483_1 1173762.S4TP28_9CAUD 1.83e-153 461.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_165337_1 697281.Mahau_0593 2.3e-05 51.6 28V3P@1|root,2ZH73@2|Bacteria,1VQEM@1239|Firmicutes,25776@186801|Clostridia,42IWQ@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - k59_124662_6 5482.XP_002551454.1 1.89e-14 78.6 COG0328@1|root,KOG3752@2759|Eukaryota,39U14@33154|Opisthokonta,3NU3Q@4751|Fungi,3QNXS@4890|Ascomycota,3RV7Q@4891|Saccharomycetes,47CY3@766764|Debaryomycetaceae 4751|Fungi L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids - GO:0000228,GO:0000278,GO:0000785,GO:0000790,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022402,GO:0022616,GO:0031974,GO:0031981,GO:0033260,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045005,GO:0046483,GO:0046700,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576,GO:1902298,GO:1902969,GO:1903047,GO:1990505 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H k59_152042_2 316278.SynRCC307_0285 6.87e-27 106.0 COG2877@1|root,COG2877@2|Bacteria,1G2XI@1117|Cyanobacteria,1GZ44@1129|Synechococcus 1117|Cyanobacteria M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_31019_1 1379715.S5TMW6_9CIRC 5.2e-44 159.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_355208_2 1156919.QWC_12603 7.57e-24 105.0 COG0741@1|root,COG0741@2|Bacteria,1N5XK@1224|Proteobacteria 1224|Proteobacteria M lytic transglycosylase activity - - - ko:K02395 - - - - ko00000,ko02035 - - - - k59_3492_5 1609634.A0A0C5AFV4_9VIRU 5.25e-124 381.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_300334_1 710696.Intca_0494 3.43e-86 261.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity - - 2.3.1.209,2.3.1.79 ko:K00661,ko:K21379 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 k59_111300_2 595537.Varpa_3838 6.73e-40 157.0 COG0666@1|root,COG1793@1|root,COG0666@2|Bacteria,COG1793@2|Bacteria,1PVQN@1224|Proteobacteria,2WBFJ@28216|Betaproteobacteria,4AHK2@80864|Comamonadaceae 28216|Betaproteobacteria L response to abiotic stimulus - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - - k59_206759_1 130478.Q9B0D2_9CAUD 5.11e-34 151.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0016032,GO:0019058,GO:0019068,GO:0044403,GO:0044419,GO:0051704,GO:0098003 - - - - - - - - - - - k59_165349_2 686340.Metal_2595 5.91e-44 154.0 2EKAP@1|root,33E0Y@2|Bacteria,1NAAI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_45696_1 679935.Alfi_0781 6.28e-07 57.4 COG3740@1|root,COG3740@2|Bacteria,4NDXV@976|Bacteroidetes,2G2G8@200643|Bacteroidia 976|Bacteroidetes S Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_344158_1 1123276.KB893246_gene581 5.96e-20 102.0 COG1524@1|root,COG3210@1|root,COG4625@1|root,COG1524@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,4NJDV@976|Bacteroidetes,47NUN@768503|Cytophagia 976|Bacteroidetes E PFAM Di-glucose binding within endoplasmic reticulum - - - - - - - - - - - - Beta_helix,Malectin,NPCBM,PA14,RicinB_lectin_2 k59_87278_1 1123057.P872_18430 3.36e-15 80.9 29YBT@1|root,30K65@2|Bacteria,4NY8W@976|Bacteroidetes,47SZM@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_209264_1 1214065.BAGV01000099_gene2075 6.89e-70 224.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_317724_2 1463821.JOGR01000004_gene2549 2.82e-79 255.0 COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis - - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_317724_4 667121.ET1_21_00760 1.08e-11 61.2 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Cold shock cspC - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_317724_5 333138.LQ50_07385 6.97e-19 86.7 COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,4HGR4@91061|Bacilli,1ZFUB@1386|Bacillus 91061|Bacilli F 2'-deoxycytidine 5'-triphosphate deaminase (DCD) dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_317724_16 1217705.F900_01831 1.38e-25 110.0 COG0507@1|root,COG5362@1|root,COG0507@2|Bacteria,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,1THDM@1236|Gammaproteobacteria,3NMMT@468|Moraxellaceae 1236|Gammaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_112945_4 1540098.A0A0A0RQI2_9CAUD 5.22e-29 124.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_180936_2 261292.Nit79A3_2318 3.82e-140 413.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VT4R@28216|Betaproteobacteria,3723T@32003|Nitrosomonadales 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_180936_6 1288494.EBAPG3_9970 5.01e-19 79.7 2BJSJ@1|root,32E4P@2|Bacteria,1PW7A@1224|Proteobacteria,2WBS8@28216|Betaproteobacteria,373PR@32003|Nitrosomonadales 28216|Betaproteobacteria S Helix-turn-helix domain - - - - - - - - - - - - HTH_17 k59_288228_2 1370121.AUWS01000006_gene5426 1.68e-08 61.2 COG0582@1|root,COG0582@2|Bacteria,2I2P9@201174|Actinobacteria,238VB@1762|Mycobacteriaceae 201174|Actinobacteria L to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_357601_1 470.IX87_07675 1.63e-42 147.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1SA7C@1236|Gammaproteobacteria,3NSKU@468|Moraxellaceae 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_381960_1 428125.CLOLEP_01413 8.68e-17 74.7 2E2Y0@1|root,32XYV@2|Bacteria,1VD9S@1239|Firmicutes,24PK0@186801|Clostridia,3WPDR@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_381960_2 1476888.X4YGV1_9CAUD 3.48e-09 57.0 4QBBW@10239|Viruses,4QXCP@35237|dsDNA viruses no RNA stage,4QQ3N@28883|Caudovirales,4QN1X@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_381960_3 411460.RUMTOR_01342 8.86e-67 209.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_233524_1 1172188.KB911820_gene2842 7.32e-10 60.5 28MN1@1|root,2ZAXN@2|Bacteria,2H2TF@201174|Actinobacteria 201174|Actinobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_410518_1 1038867.AXAY01000025_gene2084 2.22e-55 190.0 COG0553@1|root,COG0553@2|Bacteria,1PXS8@1224|Proteobacteria,2UAZ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria KL COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_317733_1 1089548.KI783301_gene2630 3e-99 312.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4HTYH@91061|Bacilli 91061|Bacilli KL DEAD-like helicases superfamily - - - - - - - - - - - - - k59_276407_4 1121441.AUCX01000012_gene3265 1.82e-36 138.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2WM78@28221|Deltaproteobacteria,2M8CT@213115|Desulfovibrionales 28221|Deltaproteobacteria S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_89775_2 1336208.JADY01000006_gene611 7.77e-21 101.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria 28211|Alphaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_346558_1 428125.CLOLEP_01409 2.41e-87 274.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_114979_1 1379858.N508_00451 3.58e-58 199.0 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,Terminase_3,Terminase_6 k59_235500_2 1327981.S0A1Q4_9CAUD 2.31e-52 172.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_346820_2 314230.DSM3645_05025 0.000558 43.5 COG0234@1|root,COG0234@2|Bacteria,2J0PC@203682|Planctomycetes 203682|Planctomycetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_102519_1 105154.Q9MBU0_9VIRU 4.96e-46 163.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_61689_1 883114.HMPREF9709_00851 1.57e-20 89.0 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,22HAA@1570339|Peptoniphilaceae 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_48022_2 1567011.A0A0A7RWK2_9VIRU 1.74e-15 75.1 4QAXV@10239|Viruses 10239|Viruses S YopX protein - - - - - - - - - - - - - k59_78477_1 32264.tetur21g01930.1 3.24e-35 127.0 COG0756@1|root,KOG3370@2759|Eukaryota,3A3T2@33154|Opisthokonta,3BIEA@33208|Metazoa,3D1WG@33213|Bilateria,41ZF1@6656|Arthropoda 33208|Metazoa F dUTP diphosphatase activity. It is involved in the biological process described with dUTP metabolic process DUT GO:0000166,GO:0000287,GO:0001889,GO:0003674,GO:0003824,GO:0004170,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010469,GO:0010646,GO:0010648,GO:0014070,GO:0015949,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0023051,GO:0023057,GO:0030545,GO:0030547,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032552,GO:0032556,GO:0034404,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0036094,GO:0042221,GO:0042975,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043497,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051259,GO:0051260,GO:0055086,GO:0061008,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0098772,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:2000272 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_360591_1 794903.OPIT5_03855 4.63e-33 132.0 COG5511@1|root,COG5511@2|Bacteria 2|Bacteria F Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_360591_2 1541883.A0A088FRT0_9CAUD 4.28e-138 425.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QJPJ@10662|Myoviridae 10662|Myoviridae S N-acetylmuramoyl-L-alanine amidase activity - GO:0005575,GO:0019012 - - - - - - - - - - - k59_89974_1 1208323.B30_16968 2.52e-15 72.0 2EMKN@1|root,3339E@2|Bacteria,1N9SW@1224|Proteobacteria,2UF94@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_331300_1 768066.HELO_2077 1e-06 53.1 COG1196@1|root,COG1196@2|Bacteria,1MU81@1224|Proteobacteria,1RS6P@1236|Gammaproteobacteria 1236|Gammaproteobacteria D tail length tape measure ynaA - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_91636_1 1121468.AUBR01000016_gene2348 9.19e-11 58.9 COG2359@1|root,COG2359@2|Bacteria,1VJPC@1239|Firmicutes,24RHB@186801|Clostridia,42ITM@68295|Thermoanaerobacterales 186801|Clostridia S Stage V sporulation protein S (SpoVS) - - - ko:K06416 - - - - ko00000 - - - SpoVS k59_23260_1 1282995.R9W0A5_9CAUD 2.63e-57 190.0 4QFB4@10239|Viruses,4QZ8P@35237|dsDNA viruses no RNA stage,4QSGK@28883|Caudovirales,4QKUP@10699|Siphoviridae 10699|Siphoviridae S viral capsid - - - - - - - - - - - - - k59_214059_1 1122179.KB890416_gene2728 8.03e-11 67.8 COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1IQYI@117747|Sphingobacteriia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,SdrD_B,SprB k59_266646_1 163908.KB235896_gene262 3.06e-17 82.0 COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,1G2VV@1117|Cyanobacteria,1HQES@1161|Nostocales 1117|Cyanobacteria Q Laminin G domain - - - - - - - - - - - - Laminin_G_3 k59_266646_2 756067.MicvaDRAFT_0259 4.5e-24 97.1 2CK1D@1|root,31KVA@2|Bacteria,1G5JE@1117|Cyanobacteria,1HB9Z@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Gas vesicle synthesis protein GvpL GvpF gvpW - - - - - - - - - - - GvpL_GvpF k59_414405_3 981335.G4W934_9CAUD 2.28e-30 115.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_323092_1 1327982.R9ZZE9_9CAUD 9.9e-68 220.0 4QGM3@10239|Viruses,4QYG4@35237|dsDNA viruses no RNA stage,4QPTC@28883|Caudovirales,4QMVS@10699|Siphoviridae 10699|Siphoviridae S oxidoreductase activity - - - - - - - - - - - - - k59_170944_1 1089544.KB912942_gene1190 6.06e-38 132.0 COG0681@1|root,COG0681@2|Bacteria,2IRPM@201174|Actinobacteria,4E625@85010|Pseudonocardiales 201174|Actinobacteria U Belongs to the peptidase S26 family - - - - - - - - - - - - - k59_116669_1 1121441.AUCX01000032_gene3179 6.1e-49 177.0 COG0503@1|root,COG0827@1|root,COG0503@2|Bacteria,COG0827@2|Bacteria,1QZ6D@1224|Proteobacteria,42Z8W@68525|delta/epsilon subdivisions,2WU49@28221|Deltaproteobacteria,2MAY9@213115|Desulfovibrionales 28221|Deltaproteobacteria LMNU Methyltransferase small domain - - - - - - - - - - - - MTS k59_63448_1 345201.073R_IIV3 3.01e-06 51.2 4QCQC@10239|Viruses,4QZGN@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_63448_3 1465751.W8QRF1_9VIRU 1.1e-53 168.0 4QC1P@10239|Viruses,4QVWJ@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_323111_2 1327990.S0A059_9CAUD 1.02e-06 53.1 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_214297_1 698758.AXY_13960 1.07e-29 125.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,4HCNN@91061|Bacilli 91061|Bacilli L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_214297_4 767817.Desgi_4530 1.47e-15 87.4 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia 186801|Clostridia L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_11864_3 941449.dsx2_0121 8.58e-46 159.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2M90H@213115|Desulfovibrionales 28221|Deltaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_133777_1 1217714.F975_01777 7.36e-39 147.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RPEK@1236|Gammaproteobacteria,3NMHD@468|Moraxellaceae 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_374831_2 1123354.AUDR01000004_gene1579 2.25e-08 63.5 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria 28216|Betaproteobacteria L Helicase - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_428805_3 991.IW20_19940 2.94e-50 167.0 COG0847@1|root,COG0847@2|Bacteria,4NPNG@976|Bacteroidetes 976|Bacteroidetes L Exonuclease - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_428805_8 1121382.JQKG01000014_gene338 5.14e-16 83.2 COG0210@1|root,COG0210@2|Bacteria,1WN9U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_224839_1 457398.HMPREF0326_03019 2.91e-142 423.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,42UU6@68525|delta/epsilon subdivisions,2X85I@28221|Deltaproteobacteria,2MCJ2@213115|Desulfovibrionales 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_374843_1 1094980.Mpsy_2684 3.45e-17 81.6 COG1573@1|root,arCOG00905@2157|Archaea,2XUVI@28890|Euryarchaeota,2N9TK@224756|Methanomicrobia 224756|Methanomicrobia L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_201358_1 1336237.JAEE01000001_gene2111 6.13e-42 159.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2 k59_53090_3 1545701.LACWKB10_0717 1.11e-11 65.9 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity - - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_402249_2 575540.Isop_3704 0.000361 48.1 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_201729_1 1465751.W8R9U1_9VIRU 3.61e-60 191.0 4QG7P@10239|Viruses,4QUU1@35237|dsDNA viruses no RNA stage 10239|Viruses S kinase activity - - - - - - - - - - - - - k59_201729_2 345201.092R_IIV3 4.59e-18 80.5 4QGXE@10239|Viruses,4QUZV@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_161705_1 1038867.AXAY01000025_gene2082 5.63e-135 415.0 COG0417@1|root,COG0417@2|Bacteria,1R7PE@1224|Proteobacteria,2TRUR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA replication proofreading - - - - - - - - - - - - - k59_309892_1 13035.Dacsa_2240 6.12e-10 58.9 COG3118@1|root,COG3118@2|Bacteria,1G6U5@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the thioredoxin family trxM1 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 5.3.4.1 ko:K01829 - - - - ko00000,ko01000 - - - Thioredoxin k59_309892_2 864563.HMPREF9166_0404 2.56e-17 86.7 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4H2TB@909932|Negativicutes 909932|Negativicutes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_283618_12 104355.XP_007865056.1 4.9e-15 81.6 KOG4569@1|root,KOG4569@2759|Eukaryota,3A0Y5@33154|Opisthokonta,3P3PN@4751|Fungi,3V3IF@5204|Basidiomycota,22F44@155619|Agaricomycetes,3H8SV@355688|Agaricomycetes incertae sedis 4751|Fungi G Alpha beta-hydrolase - - 3.1.1.73 ko:K21016 - - - - ko00000,ko01000 - - - Lipase_3 k59_310849_1 1279019.ARQK01000045_gene517 9.23e-93 319.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1R97W@1224|Proteobacteria,1TK9M@1236|Gammaproteobacteria,1X0PG@135613|Chromatiales 135613|Chromatiales D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_216188_1 1537917.JU82_09980 5.26e-10 57.8 2ARVA@1|root,31H70@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HK97-gp10_like k59_216188_2 742733.HMPREF9469_05020 9.06e-132 461.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_216188_4 323261.Noc_2757 0.000126 54.7 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - 1.1.2.6 ko:K05889,ko:K17713 - - R03136 - ko00000,ko01000,ko02000 1.B.33.1 - - Metallophos,PQQ_2,PQQ_3 k59_324108_1 1385658.U5KPZ6_9VIRU 5.13e-39 142.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_121674_4 1217705.F900_00419 1.17e-10 74.7 COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,3NKJU@468|Moraxellaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein FimV - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_121674_7 34506.g2044 7.89e-10 67.4 KOG1565@1|root,KOG1565@2759|Eukaryota,38CRR@33154|Opisthokonta,3BPTQ@33208|Metazoa,3D6Q2@33213|Bilateria,40CYE@6231|Nematoda,1KVD8@119089|Chromadorea,40SFZ@6236|Rhabditida 33208|Metazoa O Putative peptidoglycan binding domain zmp-3 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.24.12,3.4.24.80 ko:K07763,ko:K19957 ko04668,ko04912,map04668,map04912 - - - ko00000,ko00001,ko01000,ko01002 - - - PG_binding_1,Peptidase_M10 k59_391626_1 36331.EPrPI00000019198 2.03e-42 154.0 COG2877@1|root,2QQN7@2759|Eukaryota,1MB3M@121069|Pythiales 121069|Pythiales M 2-dehydro-3-deoxyphosphooctonate aldolase. Source PGD - - - - - - - - - - - - DAHP_synth_1 k59_297137_1 1676184.A0A186YBN5_9CIRC 1.06e-15 78.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_27473_2 1379715.S5TMW6_9CIRC 2.82e-49 169.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_67915_1 1064535.MELS_1947 7.02e-59 192.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_418385_1 767817.Desgi_4201 6.13e-09 61.2 COG2452@1|root,COG2452@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - HTH_17,MerR,MerR_1,Resolvase k59_94874_2 1234888.K0A2J2_9VIRU 5.23e-33 126.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_243200_1 1458862.A0A088C534_9CAUD 4.06e-46 179.0 4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses no RNA stage,4QR8A@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_310854_1 935848.JAEN01000011_gene1848 1.06e-08 60.5 COG3409@1|root,COG3409@2|Bacteria,1RAYU@1224|Proteobacteria,2U6D1@28211|Alphaproteobacteria,2PXU7@265|Paracoccus 28211|Alphaproteobacteria M N-acetylmuramidase - - - - - - - - - - - - Muraidase,PG_binding_1 k59_54620_1 105154.Q9MBU0_9VIRU 2.94e-39 143.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_67924_1 716544.wcw_0671 1.18e-56 194.0 COG4626@1|root,COG4626@2|Bacteria 2|Bacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_283787_2 1168478.I6RT73_9CAUD 9.73e-138 404.0 4QG21@10239|Viruses,4QYV7@35237|dsDNA viruses no RNA stage,4QRQT@28883|Caudovirales,4QM3S@10699|Siphoviridae 10699|Siphoviridae S Phage terminase large subunit - - - - - - - - - - - - - k59_121890_1 935261.JAGL01000009_gene1173 3.37e-62 210.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase family A - - - - - - - - - - - - DNA_pol_A k59_271148_17 305900.GV64_06125 5.98e-41 159.0 2DB7C@1|root,2Z7KN@2|Bacteria,1N20J@1224|Proteobacteria,1S0FV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_365725_1 118173.KB235910_gene4700 5.14e-21 106.0 COG4643@1|root,COG4643@2|Bacteria 2|Bacteria P DNA integration - - 2.7.7.7 ko:K02335,ko:K06919 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - Prim-Pol k59_69451_6 1463887.KL589968_gene7435 2.64e-26 110.0 COG3409@1|root,COG3409@2|Bacteria,2GR1Q@201174|Actinobacteria 201174|Actinobacteria M N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_136733_2 114615.BRADO0078 2.2e-07 50.8 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,3JYQC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_14967_1 1692252.A0A0K1RL35_9CIRC 1.27e-12 68.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_14967_2 1692252.A0A0K1RL35_9CIRC 9.57e-12 65.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_176778_1 1298858.AUEL01000029_gene95 2.31e-24 108.0 COG1345@1|root,COG1345@2|Bacteria,1QZZ9@1224|Proteobacteria,2TZSX@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Prophage tail length tape measure protein - - - - - - - - - - - - TMP_2 k59_14968_1 323848.Nmul_A1519 2.84e-06 48.9 COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,2VUMS@28216|Betaproteobacteria,374BN@32003|Nitrosomonadales 28216|Betaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_14968_2 1081644.IMCC13023_05740 2.4e-25 101.0 arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria,4FKKX@85023|Microbacteriaceae 2|Bacteria - - - - - - - - - - - - - - - k59_352558_2 1120936.KB907208_gene1116 1.17e-24 104.0 2FA48@1|root,342D2@2|Bacteria,2H6VX@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_271158_1 1429767.W6AR86_9CAUD 1.31e-16 82.8 4QEQT@10239|Viruses,4QYJH@35237|dsDNA viruses no RNA stage,4QQ1B@28883|Caudovirales,4QNPW@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_190361_1 679201.HMPREF9334_00464 2.63e-69 232.0 COG1061@1|root,COG1061@2|Bacteria,1W6ZK@1239|Firmicutes,4H76D@909932|Negativicutes 909932|Negativicutes L helicase superfamily c-terminal domain - - - - - - - - - - - - Helicase_C,ResIII k59_1478_1 428125.CLOLEP_01399 3.19e-22 92.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,3WNNS@541000|Ruminococcaceae 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_1478_2 1476888.X4YH18_9CAUD 5.72e-25 97.1 4QG3V@10239|Viruses,4QW5T@35237|dsDNA viruses no RNA stage,4QSWE@28883|Caudovirales,4QM1Q@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_56015_1 411460.RUMTOR_01350 0.000679 44.3 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_56015_2 742740.HMPREF9474_02274 4.93e-28 108.0 2DHA9@1|root,32U8X@2|Bacteria,1VD44@1239|Firmicutes,24NC3@186801|Clostridia,222SC@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_56015_3 1118055.CAGU01000013_gene758 7.01e-06 50.1 COG0860@1|root,COG1388@1|root,COG3023@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,COG3023@2|Bacteria,1TRDG@1239|Firmicutes,24ABM@186801|Clostridia,22GI4@1570339|Peptoniphilaceae 186801|Clostridia MV Cpl-7 lysozyme C-terminal domain protein - - - - - - - - - - - - Amidase_2,CW_7,Glucosaminidase,SPOR k59_56015_5 742733.HMPREF9469_05036 9.45e-29 107.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_365735_2 931276.Cspa_c09590 6.22e-11 69.3 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,36FK8@31979|Clostridiaceae 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_15178_1 484018.BACPLE_02405 1.3e-10 59.7 2A8C7@1|root,30XDU@2|Bacteria,4PAU1@976|Bacteroidetes,2FXRV@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_28961_2 1379722.S5SY31_9CIRC 3.18e-113 334.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_109524_1 572546.Arcpr_1699 4.17e-25 112.0 COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,246MK@183980|Archaeoglobi 183980|Archaeoglobi L Mcm family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_OB k59_230693_2 1027273.GZ77_20585 1.67e-11 64.3 2C6KN@1|root,32Y69@2|Bacteria,1N8AV@1224|Proteobacteria,1SFCN@1236|Gammaproteobacteria,1XQ2E@135619|Oceanospirillales 135619|Oceanospirillales S VRR-NUC domain - - - - - - - - - - - - VRR_NUC k59_380292_1 691965.D4P7D6_9CAUD 6.83e-61 221.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_97605_1 1406840.Q763_17125 1.1e-37 140.0 COG0740@1|root,COG0740@2|Bacteria,4NNEB@976|Bacteroidetes,1IN9D@117743|Flavobacteriia,2NYMF@237|Flavobacterium 976|Bacteroidetes OU Clp protease - - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_30364_1 1340829.S5Y5B9_9CAUD 5.04e-29 126.0 4QAK6@10239|Viruses,4QUQA@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_341298_3 351348.Maqu_1515 5.84e-08 53.9 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1R97W@1224|Proteobacteria,1RTIA@1236|Gammaproteobacteria,469KR@72275|Alteromonadaceae 1236|Gammaproteobacteria D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_124308_2 1237500.ANBA01000003_gene4761 1.22e-11 74.3 COG5519@1|root,COG5519@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PriCT_1,Prim-Pol k59_16584_1 1165094.RINTHH_3920 6.07e-40 145.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_16584_2 1408428.JNJP01000009_gene1355 2.67e-17 78.6 COG3108@1|root,COG3108@2|Bacteria,1NCZX@1224|Proteobacteria,42VTQ@68525|delta/epsilon subdivisions,2WMR2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_3112_1 1168289.AJKI01000041_gene3285 1.41e-19 89.0 COG0860@1|root,COG0860@2|Bacteria,4NR00@976|Bacteroidetes,2FQBB@200643|Bacteroidia 976|Bacteroidetes M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_218412_1 1094558.ME5_00054 1.19e-08 57.8 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Phage prohead protease, HK97 family - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_354763_7 310539.Q5G7P7_9CAUD 2.26e-62 199.0 4QGB5@10239|Viruses,4QXR2@35237|dsDNA viruses no RNA stage,4QSQD@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_354763_14 1007105.PT7_P073 4.88e-26 99.8 2CH99@1|root,32S5M@2|Bacteria,1N2GH@1224|Proteobacteria,2W6BX@28216|Betaproteobacteria 28216|Betaproteobacteria S Recombination enhancement, RecA-dependent nuclease - - - - - - - - - - - - RecA_dep_nuc k59_30672_2 1087482.M1EAS5_9CAUD 1.17e-06 50.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_139143_2 1121447.JONL01000002_gene1764 0.000158 46.6 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MCH7@213115|Desulfovibrionales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_72152_1 1089551.KE386572_gene4363 3.15e-13 76.3 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2TQWC@28211|Alphaproteobacteria,4BRQS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K01144,ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_84881_1 1096546.WYO_0201 1.98e-55 197.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,2UQEG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_124454_3 1121943.KB900008_gene1991 1.21e-119 393.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1R97W@1224|Proteobacteria 1224|Proteobacteria D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_422292_6 1120963.KB894514_gene385 1.66e-39 136.0 2CPEB@1|root,32SIW@2|Bacteria,1MZE0@1224|Proteobacteria,1SARU@1236|Gammaproteobacteria,2Q4T5@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_301706_1 1692244.A0A0K1RLR5_9CIRC 7.14e-65 210.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_112509_2 281090.Lxx03850 6.92e-23 99.8 2AYW5@1|root,31R1R@2|Bacteria,2HT7A@201174|Actinobacteria,4FS92@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_395650_2 345201.VF030_IIV3 2.7e-133 394.0 4QCH6@10239|Viruses,4QW59@35237|dsDNA viruses no RNA stage 10239|Viruses S telomere maintenance - - - - - - - - - - - - - k59_274000_2 1094561.MEI_00509 1.55e-51 189.0 2CC8M@1|root,308VJ@2|Bacteria,1R789@1224|Proteobacteria,2U2NB@28211|Alphaproteobacteria,48TVI@772|Bartonellaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_193416_1 1692244.A0A0K1RLR5_9CIRC 1.27e-98 296.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_153432_1 191610.CATYP_06020 2.88e-91 280.0 COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,22KVK@1653|Corynebacteriaceae 201174|Actinobacteria C Malic enzyme mez_1 - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_125643_1 1465751.W8QN18_9VIRU 1.9e-40 151.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage 10239|Viruses S N-methyltransferase activity - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - - - - - - - - - - - k59_409976_2 1223410.KN050846_gene2173 7.37e-49 163.0 COG0863@1|root,COG0863@2|Bacteria,4PIRG@976|Bacteroidetes,1I6CI@117743|Flavobacteriia 976|Bacteroidetes L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_261659_1 877424.ATWC01000003_gene1758 4.68e-15 79.7 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,27IWA@186928|unclassified Lachnospiraceae 186801|Clostridia K ParB-like nuclease domain spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_422296_1 1538804.A0A088F6T3_9CAUD 3.45e-84 286.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_86855_2 870187.Thini_1243 2.41e-06 52.8 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1SB6M@1236|Gammaproteobacteria 1236|Gammaproteobacteria K PFAM Cyclic nucleotide-binding - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_153439_1 1445613.JALM01000017_gene5872 1.43e-05 54.7 COG3941@1|root,COG5412@1|root,COG3941@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria,4E86P@85010|Pseudonocardiales 201174|Actinobacteria M phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail,SLT k59_247852_1 272942.RCAP_rcc02338 4.47e-41 144.0 2BU68@1|root,32PFD@2|Bacteria,1N2SX@1224|Proteobacteria,2UQNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_125655_2 428125.CLOLEP_01412 1.24e-47 171.0 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia,3WMZ3@541000|Ruminococcaceae 186801|Clostridia S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_343914_2 1524880.A0A076G697_9VIRU 1.17e-05 54.7 4QD1M@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_77484_5 986075.CathTA2_0263 1.14e-50 197.0 COG0358@1|root,COG3378@1|root,COG0358@2|Bacteria,COG3378@2|Bacteria,1TQP9@1239|Firmicutes,4HBTB@91061|Bacilli 91061|Bacilli L Phage plasmid primase, P4 - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,RepB_primase,Toprim_4,zf-CHC2 k59_249882_1 742725.HMPREF9450_00879 1.71e-57 196.0 COG0305@1|root,COG0305@2|Bacteria,4P0VD@976|Bacteroidetes,2FMKK@200643|Bacteroidia 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2,Toprim_4 k59_77485_1 1502724.FF80_01051 1.8e-05 53.9 COG1475@1|root,COG1475@2|Bacteria,1QAFW@1224|Proteobacteria,2U1MZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc,RepB k59_47374_2 1232427.CAVS020000018_gene1695 9.81e-06 52.8 COG5340@1|root,COG5340@2|Bacteria,2HI6T@201174|Actinobacteria,22N50@1653|Corynebacteriaceae 201174|Actinobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - DUF559 k59_61092_1 1173762.S4TP25_9CAUD 6.57e-48 176.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_220476_1 645127.ckrop_1626 9.52e-14 73.9 2EC16@1|root,3360E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4373,HTH_36 k59_127488_1 909663.KI867149_gene3261 8.06e-77 239.0 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,42TUH@68525|delta/epsilon subdivisions,2WQCB@28221|Deltaproteobacteria 28221|Deltaproteobacteria OU Serine dehydrogenase proteinase - - - - - - - - - - - - CLP_protease k59_249891_2 926556.Echvi_4543 2.57e-12 74.7 COG2911@1|root,COG2911@2|Bacteria,4NHHA@976|Bacteroidetes,47XBI@768503|Cytophagia 976|Bacteroidetes M Calx-beta domain - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3 k59_424232_3 397290.C810_01484 1.22e-39 146.0 2CWXD@1|root,32T0J@2|Bacteria,1VCVP@1239|Firmicutes,24MPK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_182313_1 765910.MARPU_05580 1.83e-87 276.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,1RZZ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3723 Recombinational DNA repair protein (RecE pathway) recT GO:0000724,GO:0000725,GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0018130,GO:0019438,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043150,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_34910_1 1123508.JH636444_gene5632 2.31e-11 68.6 COG3864@1|root,COG3864@2|Bacteria 2|Bacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_346340_1 1226322.HMPREF1545_00128 4.21e-09 57.8 2EJIR@1|root,33D9N@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Caudo_TAP,Phage_tail_APC k59_145138_1 105154.Q9MBU3_9VIRU 2.97e-13 67.8 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_127689_1 1313172.YM304_14310 3.35e-14 78.6 2F0PN@1|root,33TS2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_47594_2 99598.Cal7507_1000 2.08e-10 66.6 COG0189@1|root,COG0189@2|Bacteria 2|Bacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - - - - - - - - - - ATPgrasp_ST,ATPgrasp_Ter,COOH-NH2_lig k59_114581_1 10689.H9C0A7_BPCPT 1.27e-34 139.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_276219_1 1054461.G0XNU3_9CAUD 1.19e-22 99.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_276219_2 1283071.R9R4H0_9CAUD 4.84e-38 135.0 4QEMD@10239|Viruses,4R0JN@35237|dsDNA viruses no RNA stage,4QUGF@28883|Caudovirales,4QNXF@10744|Podoviridae 10744|Podoviridae S AAA domain - - - - - - - - - - - - - k59_195723_1 472759.Nhal_0629 1.02e-88 271.0 COG0675@1|root,COG0675@2|Bacteria,1MUU0@1224|Proteobacteria,1RY56@1236|Gammaproteobacteria,1WYVN@135613|Chromatiales 135613|Chromatiales L TIGRFAM transposase, IS605 OrfB - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_362258_1 1046714.AMRX01000006_gene3194 7.44e-25 107.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_372709_1 476272.RUMHYD_01966 3.89e-07 48.5 2EK5K@1|root,33DW0@2|Bacteria,1UU54@1239|Firmicutes,255II@186801|Clostridia 186801|Clostridia S Putative phage holin Dp-1 - - - - - - - - - - - - Phage_holin_Dp1 k59_372709_2 411460.RUMTOR_01326 4.43e-31 113.0 2EN82@1|root,33FVV@2|Bacteria,1VKRH@1239|Firmicutes,24V2G@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_236660_1 1502724.FF80_03327 2.5e-14 70.5 COG3756@1|root,COG3756@2|Bacteria,1NHNH@1224|Proteobacteria,2VGAF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_306522_1 861208.AGROH133_06202 7.61e-43 159.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_49768_1 204773.HEAR2273 4.22e-20 92.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2WBUY@28216|Betaproteobacteria,477U0@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_170659_3 1054968.G0X4V0_9CAUD 0.00014 45.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QP39@10744|Podoviridae 10744|Podoviridae S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_23214_2 411460.RUMTOR_01350 2.58e-08 56.2 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_23214_3 691965.D4P7C5_9CAUD 7.35e-110 335.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_200172_1 411460.RUMTOR_02024 8.64e-37 135.0 2A0KC@1|root,30NQJ@2|Bacteria,1V3K4@1239|Firmicutes,24HYK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_428018_1 471854.Dfer_3901 1.7e-29 112.0 2DG4N@1|root,2ZUGX@2|Bacteria,4PAWS@976|Bacteroidetes,47UQD@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_51835_1 889378.Spiaf_2417 7.21e-17 89.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity rtpR - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC k59_160590_1 1128398.Curi_c01940 7.24e-22 91.7 COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,268SU@186813|unclassified Clostridiales 186801|Clostridia F MafB19-like deaminase comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_200182_2 1443665.JACA01000007_gene106 2.58e-36 135.0 COG1216@1|root,COG1216@2|Bacteria,4NPVT@976|Bacteroidetes,1IMAC@117743|Flavobacteriia,2YJ38@290174|Aquimarina 976|Bacteroidetes S Glycosyltransferase (GlcNAc) - - - - - - - - - - - - GlcNAc k59_64995_2 1123274.KB899417_gene2175 2.81e-09 57.0 2EJIR@1|root,33D9N@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Caudo_TAP,Phage_tail_APC k59_280051_1 1313421.JHBV01000029_gene1883 1.61e-05 52.4 COG0018@1|root,COG3210@1|root,COG0018@2|Bacteria,COG3210@2|Bacteria,4NHPN@976|Bacteroidetes,1ITWW@117747|Sphingobacteriia 976|Bacteroidetes J manually curated - - - - - - - - - - - - - k59_118286_6 198467.NP92_04285 2.12e-15 84.3 COG4373@1|root,COG4373@2|Bacteria,1TQNK@1239|Firmicutes,4HDES@91061|Bacilli,21WBU@150247|Anoxybacillus 91061|Bacilli S Terminase-like family gp17a - - - - - - - - - - - Terminase_6,Terminase_6C k59_39392_1 758.BBIX01000008_gene931 1.6e-11 66.6 2CI0W@1|root,2Z81W@2|Bacteria,1R9FZ@1224|Proteobacteria,1S0NA@1236|Gammaproteobacteria,1Y9SV@135625|Pasteurellales 1236|Gammaproteobacteria S Phage X family - - - - - - - - - - - - Phage_CRI,Phage_X k59_39392_2 575564.HMPREF0014_02630 0.000124 48.1 COG1974@1|root,COG1974@2|Bacteria,1R40A@1224|Proteobacteria,1SZC7@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_133224_1 1173762.S4TNV6_9CAUD 1.13e-31 120.0 4QGGR@10239|Viruses,4QZHR@35237|dsDNA viruses no RNA stage,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_161063_1 566461.SSFG_01026 6.13e-19 83.2 2EC8I@1|root,33670@2|Bacteria,2GXUA@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_161063_2 264730.PSPPH_0669 1.42e-49 168.0 COG0175@1|root,COG0175@2|Bacteria,1QF53@1224|Proteobacteria,1RN3J@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH PFAM phosphoadenosine - - - - - - - - - - - - PAPS_reduct k59_133244_1 797515.HMPREF9103_00418 2.35e-93 300.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,3F4TZ@33958|Lactobacillaceae 91061|Bacilli L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_388909_1 1552123.EP57_03680 2.61e-13 73.6 COG3541@1|root,COG3541@2|Bacteria,1UZ8D@1239|Firmicutes,4HNEM@91061|Bacilli 91061|Bacilli S Predicted nucleotidyltransferase - - - - - - - - - - - - Nuc-transf k59_430739_6 574376.BAMA_07620 0.000536 46.6 COG0741@1|root,COG0741@2|Bacteria,1VDKZ@1239|Firmicutes,4HN7X@91061|Bacilli 91061|Bacilli M Invasion protein - - - - - - - - - - - - SLT k59_240759_1 1465751.W8QF15_9VIRU 2.11e-08 52.8 4QGWI@10239|Viruses,4QZ0E@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_240759_2 345201.VF439_IIV3 5.75e-197 563.0 4QAKR@10239|Viruses,4QUUC@35237|dsDNA viruses no RNA stage 10239|Viruses S protein serine/threonine kinase activity - - - - - - - - - - - - - k59_390676_1 478749.BRYFOR_08560 7.41e-103 337.0 COG3378@1|root,COG3378@2|Bacteria 2|Bacteria KL Phage plasmid primase P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,DUF3854,P22_AR_N,Pox_D5 k59_390681_1 1476583.DEIPH_ctg052orf0028 6.46e-45 162.0 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_6 k59_390737_1 1484479.DI14_10615 1.48e-32 125.0 COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes,4HC1I@91061|Bacilli,3WEXD@539002|Bacillales incertae sedis 91061|Bacilli H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase,HTH_3 k59_390828_1 1295642.H839_15968 4.37e-09 64.3 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,4HCI7@91061|Bacilli,1WG7G@129337|Geobacillus 91061|Bacilli S Phage portal protein - - - - - - - - - - - - Phage_portal k59_390922_1 1465751.W8QF08_9VIRU 1.41e-53 188.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage 10239|Viruses S Ribonucleotide reductase, barrel domain - GO:0001959,GO:0001960,GO:0003674,GO:0003824,GO:0004748,GO:0005575,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0010646,GO:0010648,GO:0010803,GO:0010804,GO:0016491,GO:0016725,GO:0016728,GO:0018995,GO:0023051,GO:0023057,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0055114,GO:0060759,GO:0060761,GO:0061731,GO:0065007 - - - - - - - - - - - k59_283382_1 1121396.KB892966_gene957 3.39e-09 62.8 COG0305@1|root,COG3598@1|root,COG0305@2|Bacteria,COG3598@2|Bacteria,1R4EA@1224|Proteobacteria,42TKF@68525|delta/epsilon subdivisions,2WQ0D@28221|Deltaproteobacteria,2MNNZ@213118|Desulfobacterales 28221|Deltaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25 k59_188998_1 1618247.A0A0C5IMK7_9CIRC 7.57e-11 65.9 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_121463_7 1122921.KB898194_gene770 1.34e-12 73.6 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,26TPD@186822|Paenibacillaceae 91061|Bacilli M lytic transglycosylase yjbJ - - - - - - - - - - - SLT k59_121463_19 391589.RGAI101_4264 2.28e-44 149.0 COG0720@1|root,COG0720@2|Bacteria,1RD4G@1224|Proteobacteria,2U78V@28211|Alphaproteobacteria,2P34T@2433|Roseobacter 28211|Alphaproteobacteria H COG0720 6-pyruvoyl-tetrahydropterin synthase queD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_121463_21 1201293.AKXQ01000009_gene817 5.09e-54 180.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_121463_22 485913.Krac_2794 1.17e-80 245.0 COG0302@1|root,COG0302@2|Bacteria,2G6VZ@200795|Chloroflexi 200795|Chloroflexi H PFAM GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_121463_24 937777.Deipe_1542 6.67e-105 331.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria 2|Bacteria K chromosome segregation terL - - - - - - - - - - - Terminase_6,Terminase_6C k59_121463_30 1004785.AMBLS11_13160 7.82e-21 96.3 COG3551@1|root,COG3551@2|Bacteria 2|Bacteria J Protein conserved in bacteria - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_2,Sulfotransfer_3 k59_162039_1 1089548.KI783301_gene2630 6.6e-105 323.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4HTYH@91061|Bacilli 91061|Bacilli KL DEAD-like helicases superfamily - - - - - - - - - - - - - k59_296873_4 546264.NEIFLAOT_00958 6.71e-31 120.0 2FACE@1|root,342KV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_232_1 10685.B6V2M5_BPSP1 1.33e-14 82.4 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_13684_1 292414.TM1040_1281 1.1e-24 108.0 COG5280@1|root,COG5280@2|Bacteria,1RKKJ@1224|Proteobacteria 1224|Proteobacteria S phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail k59_54234_1 864069.MicloDRAFT_00064850 1.72e-73 226.0 2C2E9@1|root,32RAA@2|Bacteria,1RF5M@1224|Proteobacteria,2U5I5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_350877_2 1492737.FEM08_11850 3.32e-06 47.8 2E9WC@1|root,33422@2|Bacteria,4NWQ7@976|Bacteroidetes,1I6BW@117743|Flavobacteriia,2NY1P@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_377867_2 1304878.AUGD01000009_gene6414 2.65e-58 194.0 2C57E@1|root,2Z8WK@2|Bacteria,1PPA2@1224|Proteobacteria,2TS2W@28211|Alphaproteobacteria,3JZ8V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Phage major capsid protein E - - - - - - - - - - - - Phage_cap_E k59_313197_1 345201.RPB1_IIV3 1.28e-123 391.0 4QARB@10239|Viruses,4QV3H@35237|dsDNA viruses no RNA stage 10239|Viruses S RNA polymerase Rpb1, domain 3 - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_29257_1 742738.HMPREF9460_04053 9.8e-53 179.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,24B1A@186801|Clostridia,26A94@186813|unclassified Clostridiales 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_285357_2 1304880.JAGB01000002_gene2229 2.31e-23 94.4 2DVY7@1|root,32V0C@2|Bacteria,1VAXX@1239|Firmicutes,24P61@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_393216_1 1038869.AXAN01000226_gene1954 1.28e-72 223.0 COG3267@1|root,COG3267@2|Bacteria,1QZKD@1224|Proteobacteria,2VQYE@28216|Betaproteobacteria,1KBQ5@119060|Burkholderiaceae 28216|Betaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_191006_1 1462526.BN990_01831 6.23e-38 144.0 COG0270@1|root,COG0270@2|Bacteria,1TPNE@1239|Firmicutes,4HHQR@91061|Bacilli 91061|Bacilli H C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_29467_1 1618248.A0A0C5IB82_9CIRC 6.38e-14 77.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_123449_1 1313421.JHBV01000155_gene784 1.06e-16 78.2 28MC2@1|root,2ZAQD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_217553_1 2754.EH55_01340 0.000219 41.6 COG3108@1|root,COG3108@2|Bacteria,3TBKC@508458|Synergistetes 508458|Synergistetes S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_179091_1 1609634.A0A0C5AFV4_9VIRU 6.68e-60 202.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_246669_2 472759.Nhal_1137 5.66e-45 149.0 COG1403@1|root,COG1403@2|Bacteria,1N6FJ@1224|Proteobacteria 1224|Proteobacteria V HNH endonuclease - - - - - - - - - - - - - k59_3714_1 691965.D4P7L3_9CAUD 7.17e-147 435.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage,4QQ8R@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_3714_19 365528.KB891159_gene5422 1.31e-20 88.6 2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4ET3Z@85013|Frankiales 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whiB2 - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_3714_30 428125.CLOLEP_01377 1.2e-56 181.0 2E0G5@1|root,32W28@2|Bacteria,1VAS0@1239|Firmicutes,24NYA@186801|Clostridia,3WNKT@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_3714_34 1256908.HMPREF0373_03028 6.23e-22 92.4 2A2ID@1|root,30QVY@2|Bacteria,1V4BJ@1239|Firmicutes,25E0Y@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_3714_35 691965.D4P7I3_9CAUD 0.0 1457.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_421391_1 1464048.JNZS01000021_gene2772 7.19e-13 73.2 COG3397@1|root,COG3397@2|Bacteria,2GM54@201174|Actinobacteria,4D8MR@85008|Micromonosporales 201174|Actinobacteria S Chitin-binding protein - - - ko:K03933 - - - - ko00000 - AA10,CBM73 - LPMO_10 k59_274569_2 61647.LG71_06515 1.55e-70 228.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_274569_3 1517681.HW45_28655 2.45e-17 82.4 COG3969@1|root,COG3969@2|Bacteria,1NBDM@1224|Proteobacteria,1RYRP@1236|Gammaproteobacteria,1XT86@135623|Vibrionales 135623|Vibrionales S Domain of unknown function (DUF3440) - - - - - - - - - - - - DUF3440,PAPS_reduct k59_357908_1 1160137.KB907309_gene5118 6.83e-64 210.0 COG0438@1|root,COG0438@2|Bacteria,2HPJ5@201174|Actinobacteria,4G5MD@85025|Nocardiaceae 201174|Actinobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_369623_1 388051.AUFE01000035_gene4020 7.82e-67 215.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_142770_1 314262.MED193_12628 4.67e-06 55.5 COG4675@1|root,COG4675@2|Bacteria,1Q4Z0@1224|Proteobacteria,2VBDH@28211|Alphaproteobacteria,2P4M9@2433|Roseobacter 28211|Alphaproteobacteria S Phage tail repeat like - - - - - - - - - - - - PTR k59_248586_1 645127.ckrop_1257 0.000132 49.3 COG0847@1|root,COG0847@2|Bacteria,2I2KI@201174|Actinobacteria,22KE5@1653|Corynebacteriaceae 201174|Actinobacteria L DNA polymerase III dnaQ2 - 2.7.7.7 ko:K02337,ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_357921_3 105154.Q9MBU6_9VIRU 2.25e-45 160.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_87611_1 1116472.MGMO_205c00030 6.36e-33 127.0 28IN7@1|root,2Z8NM@2|Bacteria,1NRFQ@1224|Proteobacteria,1SKG7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Capsid protein (F protein) - - - - - - - - - - - - Phage_F k59_75405_3 983548.Krodi_1546 0.000659 40.4 2DNW5@1|root,32ZGI@2|Bacteria,4NT26@976|Bacteroidetes,1I423@117743|Flavobacteriia,37FT0@326319|Dokdonia 976|Bacteroidetes S Rho termination factor, N-terminal domain - - - - - - - - - - - - Rho_N k59_209633_1 1158165.KB898873_gene350 4.1e-13 71.2 2DSMC@1|root,33GP4@2|Bacteria,1NCDH@1224|Proteobacteria,1T10M@1236|Gammaproteobacteria,1X1TS@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4326) - - - - - - - - - - - - DUF4326 k59_318105_2 1449126.JQKL01000024_gene2354 1.24e-16 79.3 2C3WJ@1|root,2ZHAH@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_344491_1 1173762.S4TP25_9CAUD 2.09e-134 412.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_19368_2 478749.BRYFOR_08535 5.51e-38 134.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF2800 k59_154469_2 1232410.KI421421_gene3755 1.1e-33 143.0 COG0358@1|root,COG3378@1|root,COG0358@2|Bacteria,COG3378@2|Bacteria,1QUII@1224|Proteobacteria,43AF6@68525|delta/epsilon subdivisions,2X5UX@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Poxvirus D5 protein-like - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_235476_1 477641.MODMU_1705 3.79e-28 123.0 COG0286@1|root,COG1111@1|root,COG4889@1|root,COG0286@2|Bacteria,COG1111@2|Bacteria,COG4889@2|Bacteria,2GJEP@201174|Actinobacteria,4EWCJ@85013|Frankiales 201174|Actinobacteria L site-specific DNA-methyltransferase (adenine-specific) activity - - - - - - - - - - - - N6_Mtase k59_346796_1 1168478.I6S6M4_9CAUD 1.24e-14 72.4 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QN7D@10699|Siphoviridae 10699|Siphoviridae S ATPase activity - - - - - - - - - - - - - k59_331268_1 742733.HMPREF9469_05020 1.8e-155 521.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_235483_1 1038860.AXAP01000067_gene8427 6.41e-17 84.3 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_7512_1 1121957.ATVL01000006_gene2677 3.53e-49 189.0 COG5280@1|root,COG5283@1|root,COG5280@2|Bacteria,COG5283@2|Bacteria,4NKDN@976|Bacteroidetes 976|Bacteroidetes D Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_320739_2 398525.KB900701_gene5079 4.72e-09 58.5 COG0791@1|root,COG0791@2|Bacteria,1N732@1224|Proteobacteria,2UH6X@28211|Alphaproteobacteria,3K18Y@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M NlpC/P60 family - - - - - - - - - - - - NLPC_P60 k59_320739_4 314271.RB2654_05280 4.42e-13 77.0 COG5281@1|root,COG5281@2|Bacteria,1R47M@1224|Proteobacteria,2TUIV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG5281, Phage-related minor tail protein - - - - - - - - - - - - - k59_35361_1 11082.PRO_0000037750 5.85e-86 275.0 4QBXT@10239|Viruses,4R138@439488|ssRNA viruses,4R0R1@35278|ssRNA positive-strand viruses no DNA stage 10239|Viruses K ATP-dependent helicase activity - GO:0001510,GO:0001959,GO:0001960,GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0003824,GO:0004482,GO:0004483,GO:0005488,GO:0005575,GO:0006139,GO:0006370,GO:0006396,GO:0006397,GO:0006508,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008171,GO:0008173,GO:0008174,GO:0008233,GO:0008757,GO:0009451,GO:0009452,GO:0009605,GO:0009607,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010648,GO:0010941,GO:0016032,GO:0016070,GO:0016071,GO:0016192,GO:0016556,GO:0016740,GO:0016741,GO:0016787,GO:0018995,GO:0019012,GO:0019031,GO:0019048,GO:0019049,GO:0019050,GO:0019054,GO:0019058,GO:0019065,GO:0019068,GO:0019219,GO:0019222,GO:0019538,GO:0020012,GO:0023051,GO:0023057,GO:0030260,GO:0030430,GO:0030682,GO:0030683,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031347,GO:0031348,GO:0032259,GO:0032991,GO:0032993,GO:0033592,GO:0033643,GO:0033646,GO:0033655,GO:0033668,GO:0034641,GO:0035821,GO:0036260,GO:0036265,GO:0036338,GO:0039502,GO:0039503,GO:0039526,GO:0039713,GO:0039714,GO:0042981,GO:0043067,GO:0043069,GO:0043170,GO:0043207,GO:0043412,GO:0043414,GO:0043487,GO:0043489,GO:0043656,GO:0043657,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044068,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044409,GO:0044413,GO:0044414,GO:0044415,GO:0044419,GO:0044423,GO:0044501,GO:0044531,GO:0044532,GO:0044766,GO:0045069,GO:0045070,GO:0045088,GO:0045824,GO:0045934,GO:0046483,GO:0046718,GO:0046755,GO:0046762,GO:0046794,GO:0048518,GO:0048519,GO:0048523,GO:0048524,GO:0048583,GO:0048585,GO:0050690,GO:0050776,GO:0050777,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051806,GO:0051807,GO:0051817,GO:0051828,GO:0051832,GO:0051833,GO:0051834,GO:0052027,GO:0052029,GO:0052031,GO:0052037,GO:0052040,GO:0052041,GO:0052150,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052248,GO:0052250,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052433,GO:0052490,GO:0052493,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060147,GO:0060149,GO:0060255,GO:0060338,GO:0060339,GO:0060548,GO:0060759,GO:0060761,GO:0060966,GO:0060967,GO:0060968,GO:0060969,GO:0065007,GO:0065008,GO:0071704,GO:0072583,GO:0075109,GO:0075111,GO:0075112,GO:0075114,GO:0075136,GO:0075509,GO:0075512,GO:0075528,GO:0080009,GO:0080090,GO:0080134,GO:0090304,GO:0097159,GO:0097617,GO:0098657,GO:0106005,GO:0140096,GO:0140098,GO:1900368,GO:1900369,GO:1901360,GO:1901363,GO:1901564,GO:1902369,GO:1902579,GO:1903900,GO:1903902,GO:1990814,GO:1990904 - - - - - - - - - - - k59_115207_1 1123508.JH636454_gene5742 1.69e-23 96.3 COG3728@1|root,COG3728@2|Bacteria,2J4BI@203682|Planctomycetes 203682|Planctomycetes L Terminase small subunit - - - - - - - - - - - - Terminase_2 k59_7745_2 351746.Pput_3380 1.17e-36 137.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1RMTH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_146200_1 397288.C806_01134 0.000201 51.2 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia,27NGD@186928|unclassified Lachnospiraceae 186801|Clostridia M Transglycosylase SLT domain yjbJ - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT k59_304958_1 756272.Plabr_0950 6.89e-15 71.2 2E3RU@1|root,32YPG@2|Bacteria,2J4CJ@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_347063_1 1051676.G0YPX5_9CAUD 8.28e-12 63.9 4QHC8@10239|Viruses,4QV8S@35237|dsDNA viruses no RNA stage,4QSRC@28883|Caudovirales,4QKFD@10662|Myoviridae 10662|Myoviridae S D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - - k59_9499_1 1618248.A0A0C5IB82_9CIRC 1.53e-27 114.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_306996_1 1123311.KB904475_gene1422 0.00047 49.3 28KEB@1|root,2ZA0K@2|Bacteria,1V14E@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_363247_2 691965.D4P7I3_9CAUD 0.0 999.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_349112_2 768066.HELO_2643 9.57e-37 132.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria,1S6FI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_293018_14 313596.RB2501_01415 1.24e-74 240.0 COG1061@1|root,COG2093@1|root,COG1061@2|Bacteria,COG2093@2|Bacteria,4NECV@976|Bacteroidetes,1HXAD@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF3427) - - - - - - - - - - - - Helicase_C,ResIII k59_184628_2 1123508.JH636464_gene276 3.4e-25 112.0 COG1061@1|root,COG1061@2|Bacteria,2J0ES@203682|Planctomycetes 203682|Planctomycetes L COGs COG1061 DNA or RNA helicase of superfamily II - - - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII k59_37452_1 1519439.JPJG01000088_gene695 2.31e-51 169.0 2C5J1@1|root,3067M@2|Bacteria,1V52W@1239|Firmicutes,24J2G@186801|Clostridia,2N7M3@216572|Oscillospiraceae 186801|Clostridia S COG NOG12663 non supervised orthologous group - - - - - - - - - - - - - k59_92259_2 1340534.S4X394_9CAUD 3.91e-24 107.0 4QEIG@10239|Viruses,4R0E7@35237|dsDNA viruses no RNA stage,4QTGA@28883|Caudovirales 28883|Caudovirales S regulation of transcription, DNA-dependent - - - - - - - - - - - - - k59_293479_1 391735.Veis_3757 3.5e-12 67.4 COG0175@1|root,COG0175@2|Bacteria,1PVZZ@1224|Proteobacteria,2VZAU@28216|Betaproteobacteria,4AGUC@80864|Comamonadaceae 28216|Betaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_400273_2 1122929.KB908215_gene702 1.08e-14 72.4 COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2U81X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Staphylococcal nuclease homologues - - - - - - - - - - - - SNase k59_426888_1 556269.ACDQ01000003_gene1356 2.3e-31 130.0 COG4733@1|root,COG4733@2|Bacteria,1PG9M@1224|Proteobacteria,2W1MG@28216|Betaproteobacteria,4782D@75682|Oxalobacteraceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_349461_2 665942.HMPREF1022_01523 5.53e-27 107.0 2E16H@1|root,32WMB@2|Bacteria,1N6EU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_349461_3 42565.FP66_08535 1.29e-33 120.0 COG3108@1|root,COG3108@2|Bacteria,1N6F7@1224|Proteobacteria,1SBQ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_349461_4 1304275.C41B8_05368 4.87e-12 67.4 28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_26208_3 326298.Suden_1657 2.32e-05 45.8 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2YMCT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_66038_2 1417599.U6C6Z0_9CAUD 7.44e-33 122.0 4QB55@10239|Viruses,4QW4S@35237|dsDNA viruses no RNA stage,4QSJ0@28883|Caudovirales,4QNGX@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_26212_1 762982.HMPREF9442_01223 3.28e-21 94.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia 976|Bacteroidetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_238677_1 283699.D172_0076 4.73e-08 62.0 COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,1T1TU@1236|Gammaproteobacteria,2Q1U7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_119301_4 408672.NBCG_00520 2.99e-49 163.0 COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4DQ95@85009|Propionibacteriales 201174|Actinobacteria L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_238686_2 1283299.AUKG01000006_gene827 1.05e-24 102.0 COG4325@1|root,COG4325@2|Bacteria,2GM70@201174|Actinobacteria,4CQWM@84995|Rubrobacteria 84995|Rubrobacteria M Membrane - - - - - - - - - - - - - k59_309829_1 1223545.GS4_41_00630 4.27e-15 78.6 COG4422@1|root,COG4422@2|Bacteria,2GJHQ@201174|Actinobacteria,4GGA2@85026|Gordoniaceae 201174|Actinobacteria S Pfam:Gp37_Gp68 - - - - - - - - - - - - DUF5131 k59_13787_1 633147.Olsu_0027 4.94e-13 72.8 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CUUP@84998|Coriobacteriia 84998|Coriobacteriia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_202842_1 759938.F5BSB4_9CIRC 1.89e-27 115.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_189144_1 1538804.A0A088F6T3_9CAUD 3.08e-175 513.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_162071_2 742733.HMPREF9469_05020 1.11e-119 428.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_162071_3 428125.CLOLEP_01421 4.91e-40 137.0 2ARVA@1|root,31H70@2|Bacteria,1V7JT@1239|Firmicutes,24JPE@186801|Clostridia,3WP7W@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - HK97-gp10_like k59_162071_9 1537917.JU82_06570 1.74e-59 190.0 2CGG9@1|root,2ZVSJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_162071_10 691965.D4P7D9_9CAUD 5.95e-87 270.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_162071_11 691965.D4P7D8_9CAUD 2.09e-36 125.0 4QBBW@10239|Viruses,4QXCP@35237|dsDNA viruses no RNA stage,4QQ3N@28883|Caudovirales,4QN1X@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_162071_12 428125.CLOLEP_01413 8.59e-35 122.0 2E2Y0@1|root,32XYV@2|Bacteria,1VD9S@1239|Firmicutes,24PK0@186801|Clostridia,3WPDR@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_162071_13 691965.D4P7D6_9CAUD 5.16e-202 593.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_162071_15 691965.D4P7D3_9CAUD 9.55e-162 471.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_162071_18 411460.RUMTOR_01350 7.72e-05 47.4 2EAAT@1|root,334F2@2|Bacteria,1VJJI@1239|Firmicutes,24TQU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_162071_19 1396418.BATQ01000131_gene3974 3.13e-08 66.2 COG0657@1|root,COG0657@2|Bacteria 2|Bacteria I acetylesterase activity - - - - - - - - - - - - Abhydrolase_3,F5_F8_type_C,Peptidase_S9 k59_162071_21 1550091.JROE01000002_gene737 8.1e-34 145.0 COG5164@1|root,COG5164@2|Bacteria,4NT5R@976|Bacteroidetes,1ISIJ@117747|Sphingobacteriia 976|Bacteroidetes K regulation of DNA-templated transcription, elongation - - - - - - - - - - - - LRR_5 k59_162071_24 742733.HMPREF9469_05037 2.11e-26 101.0 2BD7A@1|root,326VE@2|Bacteria,1USRB@1239|Firmicutes,25ASG@186801|Clostridia,223BG@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_162071_26 44060.JODL01000031_gene1721 1.26e-31 121.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_310704_1 1348338.ADILRU_0805 6.65e-47 164.0 COG0701@1|root,COG0701@2|Bacteria,2GJQ0@201174|Actinobacteria,4FN3N@85023|Microbacteriaceae 201174|Actinobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_297051_2 933262.AXAM01000071_gene2218 6.67e-21 93.2 28XPA@1|root,2ZJK5@2|Bacteria,1P9T2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_67853_1 1385658.U5KQQ9_9VIRU 1.55e-09 63.2 4QUMI@29258|ssDNA viruses,4QP4E@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_364537_3 404589.Anae109_1147 2.68e-13 70.1 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,42SJS@68525|delta/epsilon subdivisions,2WP7N@28221|Deltaproteobacteria,2YV9H@29|Myxococcales 28221|Deltaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_94755_1 1192124.LIG30_2095 1.3e-25 111.0 COG0419@1|root,COG0419@2|Bacteria,1R4K4@1224|Proteobacteria,2VJVF@28216|Betaproteobacteria,1K5QE@119060|Burkholderiaceae 28216|Betaproteobacteria L AAA domain recF - - - - - - - - - - - AAA_23 k59_405012_1 138119.DSY0542 1.45e-05 56.6 COG2247@1|root,COG4932@1|root,COG2247@2|Bacteria,COG4932@2|Bacteria,1UIDD@1239|Firmicutes,25EIH@186801|Clostridia,264RK@186807|Peptococcaceae 186801|Clostridia M Fibronectin type 3 domain - - - - - - - - - - - - CW_binding_2,fn3 k59_297052_1 1237149.C900_05783 2.47e-45 174.0 COG0553@1|root,COG0553@2|Bacteria,4NKAA@976|Bacteroidetes,47MHC@768503|Cytophagia 976|Bacteroidetes KL COGs COG0553 Superfamily II DNA RNA helicase SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_378039_1 326424.FRAAL2683 1.74e-40 164.0 2C5HV@1|root,33SI2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_54747_1 388051.AUFE01000035_gene4020 7.86e-53 184.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_338924_4 1410620.SHLA_1c000130 1.97e-19 93.6 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,4B7XC@82115|Rhizobiaceae 28211|Alphaproteobacteria M Membrane proteins related to metalloendopeptidases MA20_30780 - - - - - - - - - - - Peptidase_M23 k59_338924_6 113395.AXAI01000002_gene5442 1.66e-14 70.9 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria,3K04T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_176582_2 1122214.AQWH01000013_gene4472 5.54e-15 75.9 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,2PJK3@255475|Aurantimonadaceae 28211|Alphaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 - R00653 RC00165,RC00323 ko00000,ko00001,ko01000 - - - Pep_deformylase k59_190157_1 563123.B5U5I0_9CAUD 5.62e-12 66.6 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_190157_2 1476876.JOJO01000002_gene6625 7.75e-76 240.0 COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria 2|Bacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_325280_1 1231190.NA8A_23519 2.45e-44 149.0 2AGM0@1|root,316U7@2|Bacteria,1RHXP@1224|Proteobacteria,2U9RD@28211|Alphaproteobacteria,43M86@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Bacteriophage HK97-gp10, putative tail-component - - - - - - - - - - - - HK97-gp10_like k59_203934_7 93059.P9211_11951 1.36e-25 102.0 2AMM7@1|root,31CH8@2|Bacteria,1GIN8@1117|Cyanobacteria,1MMG4@1212|Prochloraceae 1117|Cyanobacteria L Pyrimidine dimer DNA glycosylase - - 3.1.25.1 ko:K01161 - - - - ko00000,ko01000 - - - Pyr_excise k59_352527_2 1232429.CBLL010000115_gene1058 1.85e-12 71.2 COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,1W822@1268|Micrococcaceae 201174|Actinobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_136647_2 310539.Q5G7N2_9CAUD 1.75e-09 60.5 4QAVB@10239|Viruses,4QVA0@35237|dsDNA viruses no RNA stage,4QPIJ@28883|Caudovirales,4QM0Q@10699|Siphoviridae 10699|Siphoviridae S Phage lysozyme - GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0008933,GO:0016032,GO:0016740,GO:0016757,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783 - - - - - - - - - - - k59_190296_1 1337093.MBE-LCI_1558 5.22e-29 108.0 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_41977_7 56780.SYN_02283 1e-15 87.8 COG4675@1|root,COG4675@2|Bacteria,1N2XN@1224|Proteobacteria 1224|Proteobacteria S tail collar domain protein - - - - - - - - - - - - - k59_286103_1 1115632.JAFW01000001_gene3221 0.000241 53.1 COG4932@1|root,COG4932@2|Bacteria,2GXWA@201174|Actinobacteria,1W96H@1268|Micrococcaceae 201174|Actinobacteria M Belongs to the peptidase S8 family - - - - - - - - - - - - CarboxypepD_reg k59_407826_1 665950.HMPREF1025_02007 3.66e-07 51.6 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_43442_1 3067.XP_002955713.1 5.7e-167 497.0 COG1372@1|root,2QRRC@2759|Eukaryota 2759|Eukaryota L reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Ribonuc_red_lgC k59_354428_1 1234888.K0A2J2_9VIRU 5.42e-41 153.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_71685_1 272134.KB731324_gene3692 6.41e-15 78.2 COG3409@1|root,COG3409@2|Bacteria,1GDBE@1117|Cyanobacteria,1HFCB@1150|Oscillatoriales 1117|Cyanobacteria M Pfam:DUF3380 - - - - - - - - - - - - Muraidase,PG_binding_1 k59_30278_1 644966.Tmar_0036 3.29e-35 132.0 COG5323@1|root,COG5323@2|Bacteria 2|Bacteria M Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_178272_1 58123.JOFJ01000015_gene4594 4.07e-57 194.0 COG0467@1|root,COG0467@2|Bacteria,2I9WA@201174|Actinobacteria 201174|Actinobacteria T AAA domain - - - - - - - - - - - - AAA_25,Prim-Pol,Toprim_3 k59_57328_2 933262.AXAM01000071_gene2218 2e-18 87.0 28XPA@1|root,2ZJK5@2|Bacteria,1P9T2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_314520_3 1507.HMPREF0262_01169 2.79e-21 92.0 2CWXD@1|root,32T0J@2|Bacteria,1VCVP@1239|Firmicutes,24MPK@186801|Clostridia,36KI7@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_327687_2 1692256.A0A0K1RL85_9CIRC 4.88e-81 254.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_30281_1 1460635.JCM19038_3446 4.71e-09 60.8 28KIJ@1|root,2ZA3S@2|Bacteria,1TSCG@1239|Firmicutes,4HF27@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_84487_1 1120917.AQXM01000058_gene463 7.27e-10 57.4 COG3266@1|root,COG3266@2|Bacteria,2GQFT@201174|Actinobacteria,1WA33@1268|Micrococcaceae 201174|Actinobacteria S lycopene cyclase crtYe - - - - - - - - - - - - k59_84487_3 1177594.MIC448_1490003 1.44e-31 119.0 COG0382@1|root,COG0382@2|Bacteria,2GKJ2@201174|Actinobacteria,4FKV3@85023|Microbacteriaceae 201174|Actinobacteria H UbiA prenyltransferase family ubiA - - ko:K20616 - - - - ko00000 - - - UbiA k59_71708_1 745718.JADT01000013_gene1385 9.74e-60 188.0 COG0791@1|root,COG0791@2|Bacteria,4NPFE@976|Bacteroidetes,1I29F@117743|Flavobacteriia 976|Bacteroidetes M CHAP domain - - - - - - - - - - - - CHAP k59_272337_1 742740.HMPREF9474_02269 5.98e-37 144.0 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia,222M5@1506553|Lachnoclostridium 186801|Clostridia S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_272337_2 428125.CLOLEP_01411 2.54e-113 345.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,3WNJZ@541000|Ruminococcaceae 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_286122_1 1618247.A0A0C5IMK7_9CIRC 9.48e-12 70.5 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_327689_1 990285.RGCCGE502_05060 2.95e-53 190.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TTEX@28211|Alphaproteobacteria,4BD81@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage terminase-like protein, large subunit - - - - - - - - - - - - Terminase_1 k59_208528_1 942016.E9NID5_9CAUD 2.45e-18 91.3 4QBMV@10239|Viruses,4QUU6@35237|dsDNA viruses no RNA stage,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_18411_1 1547445.LO80_03300 1.46e-07 57.8 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1S8D6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_356800_1 1123052.AUDF01000006_gene1407 9.76e-39 144.0 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Beta_helix,CBM_6,F5_F8_type_C,Pectate_lyase_3 k59_32382_2 1273707.L7TIC4_9CAUD 5.37e-39 135.0 4QFPC@10239|Viruses,4QXCG@35237|dsDNA viruses no RNA stage,4QPQC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_141535_7 398578.Daci_3404 3.96e-23 94.7 2EIQ2@1|root,33CFI@2|Bacteria,1NHAI@1224|Proteobacteria,2W4AT@28216|Betaproteobacteria,4AICU@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_141535_8 107636.JQNK01000008_gene4386 7.42e-59 191.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_261559_1 1121004.ATVC01000016_gene1758 3.47e-08 55.5 COG0645@1|root,COG0645@2|Bacteria,1N1S8@1224|Proteobacteria,2VWX3@28216|Betaproteobacteria 28216|Betaproteobacteria S AAA domain - - - - - - - - - - - - AAA_33 k59_261559_5 1209989.TepiRe1_2623 2.2e-17 82.0 2CGYE@1|root,31NJV@2|Bacteria,1V7Z1@1239|Firmicutes,24GBB@186801|Clostridia,42H5E@68295|Thermoanaerobacterales 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4406 k59_74148_1 691965.D4P7I3_9CAUD 9.99e-71 239.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_99819_1 218284.CCDN010000008_gene4110 1.22e-14 74.3 COG3935@1|root,COG3935@2|Bacteria,1VCAM@1239|Firmicutes,4HKS4@91061|Bacilli,1ZHP7@1386|Bacillus 91061|Bacilli L Replication initiation and membrane attachment - - - - - - - - - - - - DnaB_2 k59_32653_2 7739.XP_002593577.1 7.53e-15 75.9 COG1594@1|root,KOG1105@2759|Eukaryota,38FB2@33154|Opisthokonta,3BCWK@33208|Metazoa,3CSWZ@33213|Bilateria,483ZR@7711|Chordata 33208|Metazoa K positive regulation of exoribonuclease activity TCEA1 GO:0000428,GO:0002262,GO:0002376,GO:0002520,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005669,GO:0005730,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007275,GO:0008023,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016591,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030097,GO:0030099,GO:0030154,GO:0030218,GO:0030880,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0032069,GO:0032075,GO:0032501,GO:0032502,GO:0032774,GO:0032784,GO:0032991,GO:0033554,GO:0034101,GO:0034641,GO:0034645,GO:0034654,GO:0042592,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044798,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0048513,GO:0048518,GO:0048522,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0048872,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051336,GO:0051345,GO:0051716,GO:0055029,GO:0060255,GO:0060700,GO:0061695,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:0090575,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1901917,GO:1901919,GO:1902494,GO:1902680,GO:1903506,GO:1903508,GO:1905777,GO:1905779,GO:1990234,GO:2000112,GO:2001141 - ko:K03145 - - - - ko00000,ko03021 - - - Med26,TFIIS_C,TFIIS_M k59_193525_1 1165094.RINTHH_3920 6.3e-36 134.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_233261_2 1500894.JQNN01000001_gene4022 2.07e-14 75.1 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,472I3@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_343779_5 1121286.AUMT01000013_gene2661 0.000995 44.3 2ES7X@1|root,33JSN@2|Bacteria,4NYDY@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_182235_4 1027292.HMPREF9372_3367 1.17e-10 63.9 2CWXD@1|root,32T0J@2|Bacteria,1VCVP@1239|Firmicutes,4IRUX@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_182235_9 1429916.X566_00730 4.23e-48 165.0 COG0175@1|root,COG0175@2|Bacteria,1QZJ1@1224|Proteobacteria,2U233@28211|Alphaproteobacteria,3K3K7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_20675_1 1353531.AZNX01000018_gene5994 5.88e-46 153.0 COG0720@1|root,COG0720@2|Bacteria,1RETG@1224|Proteobacteria,2UJ9N@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_20675_2 1453496.AT03_16310 1.01e-56 186.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_20675_3 1147140.H6WRY1_9CAUD 3.57e-64 207.0 4QAXI@10239|Viruses,4QWN4@35237|dsDNA viruses no RNA stage,4QSJ9@28883|Caudovirales,4QKTR@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_303794_1 1423807.BACO01000036_gene1075 1.07e-09 62.0 2DCYU@1|root,32U0J@2|Bacteria,1VC2I@1239|Firmicutes,4IRUY@91061|Bacilli,3FBQ8@33958|Lactobacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_47509_2 1123517.JOMR01000001_gene490 3.3e-10 65.5 COG4508@1|root,COG4508@2|Bacteria 2|Bacteria S dUTPase dut - - - - - - - - - - - dUTPase_2 k59_145019_1 1236542.BALM01000010_gene3787 0.000415 42.7 COG0265@1|root,COG0265@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Pkd domain containing protein - - - - - - - - - - - - - k59_34817_3 1123508.JH636439_gene1935 2.07e-78 261.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,2J3WY@203682|Planctomycetes 203682|Planctomycetes S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_34817_5 269482.Bcep1808_1155 2.6e-35 130.0 2DM17@1|root,319VU@2|Bacteria,1R6RI@1224|Proteobacteria,2WG8E@28216|Betaproteobacteria,1KIBI@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM GIY-YIG catalytic domain - - - - - - - - - - - - - k59_155889_1 1089455.MOPEL_007_00180 1.83e-58 196.0 COG0467@1|root,COG0467@2|Bacteria,2IHK8@201174|Actinobacteria 201174|Actinobacteria T AAA domain - - - - - - - - - - - - AAA_25,DnaB k59_145021_1 1379858.N508_01020 5.27e-39 144.0 COG4974@1|root,COG4974@2|Bacteria,2GEQP@200930|Deferribacteres 200930|Deferribacteres D Phage integrase, N-terminal SAM-like domain - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_424364_1 1618254.A0A0C5IBG4_9CIRC 3.28e-133 384.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_320046_1 1096546.WYO_0164 1.87e-35 138.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria 1224|Proteobacteria L COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_211381_1 658401.C7F4B8_9CAUD 1.8e-08 62.8 4QH5W@10239|Viruses,4QYFG@35237|dsDNA viruses no RNA stage,4QQD8@28883|Caudovirales,4QN2T@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_211381_5 1123508.JH636454_gene5778 2.25e-23 100.0 COG2503@1|root,COG4639@1|root,COG2503@2|Bacteria,COG4639@2|Bacteria 2|Bacteria Q AAA domain - - - - - - - - - - - - Acid_phosphat_B k59_211381_11 655097.C8ZKH2_9CAUD 1.51e-18 94.7 4QAXA@10239|Viruses,4QYJI@35237|dsDNA viruses no RNA stage,4QQ1A@28883|Caudovirales,4QNU7@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_383142_4 1121898.Q766_15960 7.56e-171 493.0 2DBFR@1|root,2Z8ZR@2|Bacteria,4NG43@976|Bacteroidetes,1HZHP@117743|Flavobacteriia 976|Bacteroidetes S Terminase-like family - - - - - - - - - - - - Terminase_3,Terminase_6 k59_383142_5 1327981.S0A2G1_9CAUD 1.98e-144 428.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_383142_7 1327981.R9ZYI1_9CAUD 2.98e-36 137.0 4QC5Z@10239|Viruses,4QUNP@35237|dsDNA viruses no RNA stage,4QPGX@28883|Caudovirales,4QKMB@10699|Siphoviridae 10699|Siphoviridae S Phage Mu protein F like protein - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_383142_8 1089547.KB913013_gene172 2.79e-32 124.0 COG3740@1|root,COG3740@2|Bacteria,4NW89@976|Bacteroidetes,47SZC@768503|Cytophagia 976|Bacteroidetes S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_383142_9 1327981.S0A2H8_9CAUD 2.88e-126 376.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_320047_1 1465751.W8QN22_9VIRU 3.4e-40 137.0 4QCQC@10239|Viruses,4QZGN@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_320047_2 1465751.W8R9N1_9VIRU 2.71e-202 585.0 4QC2M@10239|Viruses,4QX3M@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_8980_2 511.JT27_02170 0.000213 48.1 COG4723@1|root,COG4723@2|Bacteria,1RD21@1224|Proteobacteria,2VR73@28216|Betaproteobacteria,3T7B7@506|Alcaligenaceae 28216|Betaproteobacteria S Bacteriophage lambda tail assembly protein I - - - - - - - - - - - - Lambda_tail_I k59_129786_2 348824.LPU83_1717 2.78e-17 89.7 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria,4BGD7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_277930_1 469378.Ccur_02660 8.63e-33 140.0 COG1340@1|root,COG5283@1|root,COG1340@2|Bacteria,COG5283@2|Bacteria,2I8JB@201174|Actinobacteria,4CX1V@84998|Coriobacteriia 84998|Coriobacteriia S Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_426175_1 1536775.H70737_27160 2.05e-07 60.1 2F5GB@1|root,33Y1Y@2|Bacteria,1VWA9@1239|Firmicutes,4ISQ2@91061|Bacilli,2776D@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_116439_1 1121481.AUAS01000035_gene2877 2.08e-06 52.4 COG4067@1|root,COG4067@2|Bacteria,4NS86@976|Bacteroidetes,47RH0@768503|Cytophagia 976|Bacteroidetes O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_251864_1 702450.CUW_0526 6.27e-09 56.6 COG4570@1|root,COG4570@2|Bacteria,1VF2H@1239|Firmicutes,3VRYF@526524|Erysipelotrichia 526524|Erysipelotrichia L Endodeoxyribonuclease RusA rusA - - - - - - - - - - - RusA k59_50030_1 2880.D7G905 8.29e-08 56.6 COG0756@1|root,KOG3370@2759|Eukaryota 2759|Eukaryota F dUTP metabolic process DUT GO:0000166,GO:0000287,GO:0001889,GO:0003674,GO:0003824,GO:0004170,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006259,GO:0006260,GO:0006281,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010469,GO:0010646,GO:0010648,GO:0014070,GO:0015949,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0023051,GO:0023057,GO:0030545,GO:0030547,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032552,GO:0032556,GO:0033554,GO:0034404,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0036094,GO:0042221,GO:0042802,GO:0042975,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043497,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051259,GO:0051260,GO:0051716,GO:0055086,GO:0061008,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0098772,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:2000272 3.5.1.122,3.6.1.23 ko:K01520,ko:K21286 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11560,R11896 RC00002,RC00010 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_323128_2 1504822.CCNO01000013_gene307 6.27e-26 108.0 2CHRY@1|root,30Z9E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - RecT k59_348861_1 1235835.C814_01029 5.74e-11 67.4 2E1MQ@1|root,32WYT@2|Bacteria,1VB8R@1239|Firmicutes,24PR7@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_23448_2 1397528.Q671_04965 2.38e-11 75.1 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,1RSQN@1236|Gammaproteobacteria,1XJ09@135619|Oceanospirillales 135619|Oceanospirillales L Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C,ResIII k59_104279_2 1156919.QWC_12518 8.73e-19 82.8 COG4570@1|root,COG4570@2|Bacteria,1N92D@1224|Proteobacteria 1224|Proteobacteria L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC rusA - 3.1.22.4 ko:K01160 - - - - ko00000,ko01000,ko03400 - - - RusA k59_268886_1 390235.PputW619_1296 6e-07 51.6 COG1551@1|root,COG1551@2|Bacteria 2|Bacteria T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA2 - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_416547_1 573370.DMR_15020 8.52e-20 96.3 COG3378@1|root,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,42YMP@68525|delta/epsilon subdivisions,2WUNJ@28221|Deltaproteobacteria,2MGFT@213115|Desulfovibrionales 1224|Proteobacteria S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_200619_1 1123057.P872_16495 2.9e-77 248.0 COG0162@1|root,COG0162@2|Bacteria,4NF19@976|Bacteroidetes,47JXG@768503|Cytophagia 976|Bacteroidetes J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_173549_1 1157635.KB892046_gene5768 2.41e-07 53.9 COG0739@1|root,COG1842@1|root,COG3953@1|root,COG0739@2|Bacteria,COG1842@2|Bacteria,COG3953@2|Bacteria,2I5MH@201174|Actinobacteria 201174|Actinobacteria D Transglycosylase SLT domain - - - - - - - - - - - - Peptidase_M23,SLT k59_65668_1 665956.HMPREF1032_00647 8.32e-35 137.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,3WNBH@541000|Ruminococcaceae 186801|Clostridia S DNA polymerase type-B family - - - - - - - - - - - - - k59_386300_1 553217.ENHAE0001_2198 2.98e-35 145.0 COG4643@1|root,COG5519@1|root,COG4643@2|Bacteria,COG5519@2|Bacteria,1QU3K@1224|Proteobacteria 1224|Proteobacteria L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - DUF3987,Prim-Pol k59_106600_1 679192.HMPREF9013_1318 0.000643 43.9 28HHC@1|root,2Z7T2@2|Bacteria,1TR3B@1239|Firmicutes,3VQ9J@526524|Erysipelotrichia 526524|Erysipelotrichia S AAA domain - - - - - - - - - - - - AAA_24 k59_106600_2 1304880.JAGB01000002_gene2229 2e-22 92.0 2DVY7@1|root,32V0C@2|Bacteria,1VAXX@1239|Firmicutes,24P61@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_402087_1 1235661.K0IP52_9CAUD 5.26e-21 97.8 4QAUF@10239|Viruses,4QWIQ@35237|dsDNA viruses no RNA stage,4QUFS@28883|Caudovirales,4QNVK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_201093_2 471870.BACINT_02219 8.87e-61 203.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_186717_1 1692244.A0A0K1RLR5_9CIRC 8.28e-27 112.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_133560_1 311424.DhcVS_1286 8.99e-26 107.0 2DBHG@1|root,2Z99H@2|Bacteria 2|Bacteria - - mom - - ko:K21527 - - - - ko00000,ko01000 - - - - k59_309398_1 388051.AUFE01000035_gene4020 4.19e-15 84.7 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_133577_1 1555208.A0A097EVZ7_9CAUD 1.34e-36 142.0 4QAQ9@10239|Viruses,4QPTV@28883|Caudovirales,4QKRS@10699|Siphoviridae 10699|Siphoviridae S Putative phage tail protein - GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044406,GO:0044419,GO:0044650,GO:0051704 - - - - - - - - - - - k59_309402_2 1203611.KB894542_gene690 3.27e-27 103.0 COG2131@1|root,COG2131@2|Bacteria,4NM48@976|Bacteroidetes,2FRZ1@200643|Bacteroidia,22UEX@171550|Rikenellaceae 976|Bacteroidetes F Cytidine and deoxycytidylate deaminase zinc-binding region comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_296283_1 1504822.CCNO01000015_gene594 5.1e-57 198.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_296283_2 266779.Meso_1200 2.35e-09 58.2 COG0863@1|root,COG0863@2|Bacteria,1NQ2A@1224|Proteobacteria,2UJ12@28211|Alphaproteobacteria,43KMC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_161973_4 1415148.V5Q7F6_9CAUD 9.77e-38 132.0 4QDCQ@10239|Viruses,4QVJW@35237|dsDNA viruses no RNA stage,4QPZZ@28883|Caudovirales,4QM93@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF1768) - - - - - - - - - - - - - k59_202439_1 1205681.CALW02000066_gene568 4e-23 102.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_135012_6 1192868.CAIU01000008_gene960 1.52e-56 194.0 2C2XN@1|root,32GT6@2|Bacteria,1REZE@1224|Proteobacteria,2U8HW@28211|Alphaproteobacteria,43QAV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_310402_5 1286093.C266_04699 7.21e-38 144.0 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,2VKVD@28216|Betaproteobacteria,1K5XV@119060|Burkholderiaceae 28216|Betaproteobacteria S COG4386 Mu-like prophage tail sheath protein gpL - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k59_13634_1 1123058.KB894259_gene376 3.14e-06 48.5 COG3935@1|root,COG3935@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Phg_2220_C k59_364317_2 1692255.A0A0K1RL52_9CIRC 1.62e-106 320.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_67635_1 1121100.JCM6294_1077 4.03e-21 89.0 COG0847@1|root,COG0847@2|Bacteria,4NPNG@976|Bacteroidetes,2FS7S@200643|Bacteroidia,4ATCY@815|Bacteroidaceae 976|Bacteroidetes L Exonuclease - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_377822_1 76636.JOEC01000002_gene2584 2.66e-26 105.0 COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4FMKM@85023|Microbacteriaceae 201174|Actinobacteria O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_297010_1 1692255.A0A0K1RL52_9CIRC 4.64e-46 162.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_297010_3 1618248.A0A0C5IB82_9CIRC 1.16e-18 84.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_54421_2 1172188.KB911820_gene2876 4.83e-55 193.0 COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria 201174|Actinobacteria L helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_121608_1 1123299.AUKZ01000018_gene194 5.35e-07 51.6 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH,HNH_5 k59_121608_2 1219031.BBJR01000049_gene1546 9.81e-30 114.0 2CIEP@1|root,315ZW@2|Bacteria,1NVZS@1224|Proteobacteria,2W2U4@28216|Betaproteobacteria,4AHV4@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_176746_2 1038860.AXAP01000015_gene2006 8.11e-29 118.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_95947_2 1173028.ANKO01000204_gene4722 1.85e-60 194.0 COG2304@1|root,COG2304@2|Bacteria,1G11R@1117|Cyanobacteria,1H7TP@1150|Oscillatoriales 1117|Cyanobacteria S von Willebrand factor, type A - - - - - - - - - - - - VWA_2,vWA-TerF-like k59_95947_3 31033.ENSTRUP00000006276 1.69e-09 65.5 COG5640@1|root,KOG3627@2759|Eukaryota,39U11@33154|Opisthokonta,3BDTB@33208|Metazoa,3D0T5@33213|Bilateria,482CU@7711|Chordata,48ZVH@7742|Vertebrata,49QD9@7898|Actinopterygii 33208|Metazoa E Transmembrane protease serine 9-like - - - ko:K09628,ko:K09630,ko:K09640 - - - - ko00000,ko01000,ko01002 - - - Trypsin k59_419447_2 753084.F4YCM7_9CAUD 1.38e-46 151.0 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_150066_2 1123276.KB893246_gene850 1.96e-09 63.9 COG1403@1|root,COG1403@2|Bacteria,4NJ0T@976|Bacteroidetes,47MEF@768503|Cytophagia 976|Bacteroidetes L HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_82680_8 1463856.JOHY01000005_gene2033 3.35e-22 88.2 2C3CA@1|root,2ZUNU@2|Bacteria,2GZBJ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_216985_1 1210884.HG799467_gene13131 3.25e-29 121.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_56144_1 1692249.A0A0K1RLN8_9CIRC 8.93e-21 94.4 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_392769_3 118166.JH976537_gene1678 3.24e-136 405.0 COG0175@1|root,COG0175@2|Bacteria,1GCMX@1117|Cyanobacteria,1HF9G@1150|Oscillatoriales 1117|Cyanobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_392769_7 1121935.AQXX01000144_gene4541 1.82e-28 116.0 COG0847@1|root,COG0847@2|Bacteria,1N4WX@1224|Proteobacteria,1SC32@1236|Gammaproteobacteria,1XQ3Z@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III, epsilon subunit and related 3'-5' - - - - - - - - - - - - RNase_T k59_392769_19 420324.KI912045_gene4283 8.27e-45 157.0 COG4870@1|root,COG4870@2|Bacteria 2|Bacteria O transferase activity, transferring glycosyl groups - - - - - - - - - - - - PKD,Peptidase_C1 k59_1650_1 882.DVU_2153 2.08e-18 89.7 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,42QDD@68525|delta/epsilon subdivisions,2WIU9@28221|Deltaproteobacteria,2MEC5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage-related protein, tail - - - - - - - - - - - - Phage-tail_3 k59_163301_1 1121286.AUMT01000001_gene33 6.28e-115 340.0 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_28939_3 649639.Bcell_2721 6.2e-108 357.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HGW7@91061|Bacilli,1ZBWW@1386|Bacillus 91061|Bacilli D phage tail tape measure protein - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k59_109506_1 443143.GM18_2483 1.57e-30 122.0 COG1216@1|root,COG1216@2|Bacteria,1R60D@1224|Proteobacteria,42UZ2@68525|delta/epsilon subdivisions,2WR0Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1,Glycos_transf_2 k59_42202_1 1117315.AHCA01000019_gene4254 3.36e-10 62.4 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RR51@1236|Gammaproteobacteria,2Q40D@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P Protein of unknown function (DUF229) - - - - - - - - - - - - Sulfatase k59_82929_1 105154.Q9MBU3_9VIRU 0.000232 45.8 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_82929_2 1385658.U5KPZ6_9VIRU 1.08e-224 637.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_82929_4 1165094.RINTHH_3920 3.96e-83 259.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_259476_1 1540097.A0A0A0YPY2_9CAUD 3.35e-50 173.0 4QGGR@10239|Viruses,4QUGZ@28883|Caudovirales,4QNY3@10744|Podoviridae 10744|Podoviridae S viral capsid - - - - - - - - - - - - - k59_394060_2 444860.E3SJ76_9CAUD 3.39e-132 385.0 4QCFA@10239|Viruses,4QUPF@35237|dsDNA viruses no RNA stage,4QQD7@28883|Caudovirales,4QIYX@10662|Myoviridae 10662|Myoviridae S coenzyme binding - - - - - - - - - - - - - k59_408233_1 1523503.JPMY01000010_gene2747 1.37e-07 60.8 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins psmE - - - - - - - - - - - Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C k59_421027_2 1047013.AQSP01000109_gene2428 7.31e-18 91.7 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_421027_14 1125863.JAFN01000001_gene1263 2.33e-39 138.0 2E8ZK@1|root,33394@2|Bacteria,1NFCZ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_231926_1 1031288.AXAA01000003_gene1624 2.01e-08 57.8 COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,36JJM@31979|Clostridiaceae 186801|Clostridia M Sortase family - - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_286442_2 985867.AEWF01000012_gene1288 4.34e-66 213.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,47EWD@766|Rickettsiales 28211|Alphaproteobacteria D involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_272673_1 1173762.S4TP28_9CAUD 2.85e-58 202.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_300166_1 391613.RTM1035_02365 3.95e-52 185.0 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,2U3TE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_111115_6 297246.lpp2117 2.03e-29 131.0 COG0305@1|root,COG0305@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria,1JDPV@118969|Legionellales 118969|Legionellales L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,Toprim_2 k59_300169_1 1123024.AUII01000033_gene1376 2.01e-44 166.0 COG0717@1|root,COG1372@1|root,COG0717@2|Bacteria,COG1372@2|Bacteria,2H62G@201174|Actinobacteria 201174|Actinobacteria L TIGRFAM Phage - - - - - - - - - - - - - k59_286458_1 391613.RTM1035_11170 9.52e-43 154.0 COG0582@1|root,COG0582@2|Bacteria,1Q7U3@1224|Proteobacteria,2VAXI@28211|Alphaproteobacteria,46RCC@74030|Roseovarius 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_341774_1 1395516.PMO01_03075 9.17e-24 100.0 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,1SCZN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - AP2,HNH_3 k59_206562_2 1217714.F975_01637 3.58e-27 126.0 COG0454@1|root,COG1040@1|root,COG0456@2|Bacteria,COG1040@2|Bacteria,1QV41@1224|Proteobacteria,1RSAP@1236|Gammaproteobacteria,3NM26@468|Moraxellaceae 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_408256_1 398511.BpOF4_19015 2.69e-15 73.2 COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,4HB1Y@91061|Bacilli,1ZCJD@1386|Bacillus 91061|Bacilli F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_408256_2 445970.ALIPUT_02667 4.52e-70 226.0 2BKC5@1|root,32ESM@2|Bacteria,4PAIX@976|Bacteroidetes,2FX36@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_408256_3 762982.HMPREF9442_01170 1e-23 102.0 COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FRXC@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4417,ParBc k59_192051_1 768671.ThimaDRAFT_0726 1.49e-09 62.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,1WX24@135613|Chromatiales 135613|Chromatiales S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_18905_1 265072.Mfla_2685 2.2e-09 66.6 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2VJEP@28216|Betaproteobacteria 28216|Betaproteobacteria NT Phage-related protein, tail - - - - - - - - - - - - DUF1983,Phage-tail_3 k59_4998_3 1442598.JABW01000024_gene1562 3.31e-09 61.6 COG0640@1|root,COG0640@2|Bacteria,1RGKD@1224|Proteobacteria 1224|Proteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_36 k59_219382_1 1410634.JHVD01000028_gene2099 5.31e-15 71.6 COG4570@1|root,COG4570@2|Bacteria,2GV9V@201174|Actinobacteria 201174|Actinobacteria L Endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_219382_2 1219084.AP014508_gene1992 1.61e-12 66.2 COG2359@1|root,COG2359@2|Bacteria,2GDB6@200918|Thermotogae 200918|Thermotogae S PFAM Stage V sporulation protein S - - - ko:K06416 - - - - ko00000 - - - SpoVS k59_274249_1 1380391.JIAS01000017_gene662 1.65e-21 97.8 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2JPRR@204441|Rhodospirillales 204441|Rhodospirillales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_317600_2 203124.Tery_4575 1.72e-10 64.3 COG1086@1|root,COG1086@2|Bacteria,1GAM2@1117|Cyanobacteria,1HHRQ@1150|Oscillatoriales 1117|Cyanobacteria GM Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_317600_4 31234.CRE25384 1.85e-05 52.8 COG1428@1|root,KOG3877@2759|Eukaryota,38H1R@33154|Opisthokonta,3BEI2@33208|Metazoa,3D284@33213|Bilateria,40CGK@6231|Nematoda,1KTW0@119089|Chromadorea,40ZA2@6236|Rhabditida 33208|Metazoa C Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone NDUFA10 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010257,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 - ko:K03954 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00146 - - ko00000,ko00001,ko00002 3.D.1.6 - - dNK k59_288079_2 172088.AUGA01000017_gene2380 7.96e-62 201.0 COG3206@1|root,COG3206@2|Bacteria,1ND5H@1224|Proteobacteria,2UIQZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - k59_381851_2 1589297.A0A0B5H2N3_9CAUD 2.21e-101 301.0 4QEMD@10239|Viruses,4QUGF@28883|Caudovirales,4QNXF@10744|Podoviridae 10744|Podoviridae S AAA domain - - - - - - - - - - - - - k59_59478_1 1163617.SCD_n02931 7.08e-38 149.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_344268_1 1419583.V466_18010 1.75e-40 148.0 2C96H@1|root,2Z7Q6@2|Bacteria,1PQG4@1224|Proteobacteria,1S1DX@1236|Gammaproteobacteria,1YSVU@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Sulfotransferase domain - - - ko:K13472 ko04626,map04626 - - - ko00000,ko00001 - - - Sulfotransfer_3 k59_344274_2 1476888.X4Y7Y5_9CAUD 1.17e-36 140.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_219536_1 1243664.CAVL020000008_gene4164 1.79e-07 50.8 COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,4IS2P@91061|Bacilli,1ZS0T@1386|Bacillus 91061|Bacilli O Glutaredoxin - - - - - - - - - - - - Glutaredoxin k59_127679_1 644966.Tmar_2128 0.000221 46.2 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WCFZ@538999|Clostridiales incertae sedis 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_155940_2 1188256.BASI01000001_gene345 1.94e-36 128.0 2C58H@1|root,32YYI@2|Bacteria,1N7UA@1224|Proteobacteria,2UHCE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S NinB protein - - - - - - - - - - - - NinB k59_220673_2 1463858.JOHR01000024_gene4106 5.8e-24 103.0 COG0270@1|root,COG0270@2|Bacteria,2GJS2@201174|Actinobacteria 201174|Actinobacteria L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_7064_1 1423144.Gal_02288 1.83e-23 99.0 COG1403@1|root,COG1403@2|Bacteria,1N0FM@1224|Proteobacteria,2TWQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ERF superfamily - - - - - - - - - - - - ERF k59_331212_1 655815.ZPR_4103 3.5e-46 153.0 28MZE@1|root,2ZB64@2|Bacteria,4NK76@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_412649_1 948071.S4S2L2_9CAUD 2.39e-06 57.4 4QHQ5@10239|Viruses,4QR7K@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_145627_1 1692252.A0A0K1RL35_9CIRC 2.16e-84 261.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_156254_7 537874.B3GVZ0_9CAUD 1.38e-06 52.0 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales 28883|Caudovirales S protein disulfide oxidoreductase activity - - - - - - - - - - - - - k59_7425_1 192875.XP_004365048.1 3.63e-25 116.0 COG0553@1|root,KOG1001@2759|Eukaryota,38E02@33154|Opisthokonta 33154|Opisthokonta KL helicase activity - GO:0000003,GO:0000228,GO:0000278,GO:0000724,GO:0000725,GO:0000775,GO:0000776,GO:0000777,GO:0000778,GO:0000779,GO:0000780,GO:0000785,GO:0000790,GO:0000793,GO:0000794,GO:0003006,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006282,GO:0006302,GO:0006310,GO:0006325,GO:0006333,GO:0006338,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007154,GO:0007530,GO:0007531,GO:0007533,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009605,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0009991,GO:0010605,GO:0016043,GO:0016462,GO:0016567,GO:0016740,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0019787,GO:0022402,GO:0022413,GO:0022414,GO:0030154,GO:0030162,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031668,GO:0031974,GO:0031981,GO:0032182,GO:0032183,GO:0032268,GO:0032269,GO:0032392,GO:0032434,GO:0032435,GO:0032446,GO:0032502,GO:0032505,GO:0032508,GO:0032991,GO:0033260,GO:0033554,GO:0034641,GO:0034645,GO:0035861,GO:0036211,GO:0042176,GO:0042177,GO:0042262,GO:0042623,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045005,GO:0045165,GO:0045738,GO:0045861,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051276,GO:0051716,GO:0060255,GO:0061136,GO:0061630,GO:0061659,GO:0065007,GO:0070013,GO:0070035,GO:0070647,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0090734,GO:0098687,GO:0140083,GO:0140096,GO:0140097,GO:1901360,GO:1901564,GO:1901576,GO:1901799,GO:1902298,GO:1902969,GO:1903047,GO:1903050,GO:1903051,GO:1903362,GO:1903363,GO:1990505,GO:2000058,GO:2000059,GO:2000779,GO:2000780,GO:2001020,GO:2001021,GO:2001032,GO:2001033 2.3.2.27 ko:K15710 - - - - ko00000,ko01000,ko04121 - - - Helicase_C,SNF2_N,zf-C3HC4,zf-C3HC4_2,zf-C3HC4_3,zf-RING_UBOX k59_211855_1 441620.Mpop_2675 7.07e-14 78.6 COG3941@1|root,COG5281@1|root,COG3941@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2U3WK@28211|Alphaproteobacteria 28211|Alphaproteobacteria D tape measure protein - - - - - - - - - - - - Peptidase_M15_4,Tape_meas_lam_C k59_89877_1 1392490.JHZX01000001_gene233 2.56e-22 100.0 COG1484@1|root,COG1484@2|Bacteria,4NFYG@976|Bacteroidetes,1HYFC@117743|Flavobacteriia 976|Bacteroidetes L DNA-dependent DNA replication - - - - - - - - - - - - - k59_380276_15 1121382.JQKG01000015_gene1651 1.79e-32 137.0 COG0286@1|root,COG0286@2|Bacteria,1WMMI@1297|Deinococcus-Thermus 2|Bacteria V site-specific DNA-methyltransferase (adenine-specific) activity - - - - - - - - - - - - DUF4376,HsdM_N,MTS,N6_Mtase k59_380276_18 487316.BBNM01000011_gene45 3.65e-10 63.2 COG2852@1|root,COG2852@2|Bacteria,1N7EJ@1224|Proteobacteria,1SF5D@1236|Gammaproteobacteria,3NP22@468|Moraxellaceae 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF559 k59_380276_24 46234.ANA_C12030 2.27e-06 53.9 296W7@1|root,2ZU50@2|Bacteria,1G5U4@1117|Cyanobacteria,1HNI1@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_84542_1 10685.B6V2J2_BPSP1 8.92e-32 129.0 4QBA2@10239|Viruses,4QV98@35237|dsDNA viruses no RNA stage,4QPPI@28883|Caudovirales,4QIA3@10662|Myoviridae 10662|Myoviridae S Thymidylate synthase - - - - - - - - - - - - - k59_231592_1 1232449.BAHV02000008_gene620 5.11e-45 167.0 COG1061@1|root,COG1061@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia,26AMR@186813|unclassified Clostridiales 186801|Clostridia L helicase superfamily c-terminal domain - - - - - - - - - - - - HNH,Helicase_C,ResIII k59_84544_1 1168547.L7P648_9CIRC 4.9e-32 126.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_30335_1 1370120.AUWR01000013_gene3352 5.89e-33 138.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,232KV@1762|Mycobacteriaceae 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_71775_3 145579.C_BPPHM 1.51e-10 59.3 4QCC5@10239|Viruses,4QUKW@29258|ssDNA viruses,4QP4C@10841|Microviridae 10841|Microviridae S viral process - - - - - - - - - - - - - k59_71775_4 1385658.U5KPZ6_9VIRU 5.46e-222 631.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_341279_1 1172188.KB911820_gene2855 4.58e-54 197.0 COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4FITX@85021|Intrasporangiaceae 201174|Actinobacteria S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_57401_3 257310.BB1661 3.94e-32 122.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,2VRP1@28216|Betaproteobacteria,3T1G1@506|Alcaligenaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_286342_5 1120936.KB907208_gene1108 1.65e-73 238.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4EGN4@85012|Streptosporangiales 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - - - - - - - - - - RecA k59_99737_1 1120963.KB894509_gene2068 3.45e-11 69.3 2DPZ6@1|root,3341A@2|Bacteria,1R2F6@1224|Proteobacteria,1T5PJ@1236|Gammaproteobacteria 2|Bacteria - - - - - - - - - - - - - - - k59_410006_1 771875.Ferpe_1851 4.27e-08 63.2 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,2GCPE@200918|Thermotogae 200918|Thermotogae M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,TPR_2,TPR_8 k59_274024_6 1123320.KB889574_gene5516 2.88e-07 51.6 2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whiB3 - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_301765_1 1123508.JH636442_gene4024 4.08e-43 154.0 COG0582@1|root,COG0582@2|Bacteria,2IZWA@203682|Planctomycetes 203682|Planctomycetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase k59_141733_1 69328.PVLB_09435 3.05e-29 115.0 COG3935@1|root,COG3935@2|Bacteria,1N2SH@1224|Proteobacteria,1SBMX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DnaD domain protein - - - - - - - - - - - - - k59_141733_2 1157708.KB907450_gene5414 4.46e-51 169.0 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - HNH,HNH_5 k59_288017_2 1235793.C809_02225 7.9e-77 246.0 COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia 186801|Clostridia S Mu-like prophage protein gp29 - - - - - - - - - - - - - k59_99990_1 479431.Namu_4483 1.01e-05 53.9 COG3147@1|root,COG3147@2|Bacteria,2I8WA@201174|Actinobacteria,4EVET@85013|Frankiales 201174|Actinobacteria N Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix k59_4958_1 1144343.PMI41_01924 6.91e-34 121.0 2DWM7@1|root,340ZN@2|Bacteria,1NXQW@1224|Proteobacteria,2UT9X@28211|Alphaproteobacteria,43QIP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_18880_1 1286619.L7WUM1_9CIRC 4.29e-20 87.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_20861_1 1125779.HMPREF1219_00149 0.000178 45.1 2DP0V@1|root,3302I@2|Bacteria,2I84T@201174|Actinobacteria 201174|Actinobacteria S Endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_319962_3 227720.Q858M9_9CAUD 6.19e-08 54.3 4QAZF@10239|Viruses,4QUTY@35237|dsDNA viruses no RNA stage,4QPH6@28883|Caudovirales,4QNEM@10744|Podoviridae 10744|Podoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_114481_1 469008.B21_02376___1 4.74e-110 317.0 COG2963@1|root,COG2963@2|Bacteria,1N09R@1224|Proteobacteria,1SA5V@1236|Gammaproteobacteria,3XR6W@561|Escherichia 1236|Gammaproteobacteria L Brinker DNA-binding domain - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_168946_1 1121448.DGI_2056 1.81e-10 61.6 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,42QKN@68525|delta/epsilon subdivisions,2WK3R@28221|Deltaproteobacteria,2MA6M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_168946_3 1111454.HMPREF1250_0249 2.09e-09 62.0 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,4H3A0@909932|Negativicutes 909932|Negativicutes L Phage portal protein - - - - - - - - - - - - Phage_portal k59_7171_4 478749.BRYFOR_08522 1.53e-85 274.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_276329_1 111781.Lepto7376_2280 0.000573 45.8 COG0454@1|root,COG0456@2|Bacteria,1G1VS@1117|Cyanobacteria,1HE6T@1150|Oscillatoriales 1117|Cyanobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_304231_1 1379709.S5TMV0_9CIRC 3.57e-18 86.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_360209_1 1147157.K7PJW8_9CAUD 1.21e-16 82.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_360209_2 1144932.ATTF01000014_gene1158 3.19e-10 63.9 2EDRD@1|root,337KY@2|Bacteria,1NF3A@1224|Proteobacteria,2UKF1@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_264434_2 390874.Tpet_1644 3.01e-26 107.0 COG0125@1|root,COG0125@2|Bacteria,2GD5T@200918|Thermotogae 200918|Thermotogae F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1099 Thymidylate_kin k59_21138_3 1385658.U5KNR1_9VIRU 1.98e-31 120.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_35060_1 10704.B4UTP0_BP163 2.32e-38 145.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_371092_1 411460.RUMTOR_01335 2.77e-66 228.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_220765_2 1618238.A0A0C5IB41_9CIRC 4.37e-06 55.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_47731_1 388051.AUFE01000035_gene4020 1.38e-78 253.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_61431_1 1313301.AUGC01000010_gene881 8.06e-26 113.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_322680_10 1476902.A0A097P6S4_9CAUD 5.34e-49 193.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QHYN@10662|Myoviridae 10662|Myoviridae S amidase activity - - - - - - - - - - - - - k59_103955_1 1121101.HMPREF1532_02597 1.55e-62 207.0 COG1783@1|root,COG1783@2|Bacteria,4PMA2@976|Bacteroidetes,2G2CX@200643|Bacteroidia,4AVWS@815|Bacteroidaceae 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_129811_1 991.IW20_24885 9.77e-19 88.6 COG1562@1|root,COG1562@2|Bacteria,4NEIK@976|Bacteroidetes,1HXBH@117743|Flavobacteriia,2NUZW@237|Flavobacterium 976|Bacteroidetes I Phytoene synthase crtB - - - - - - - - - - - SQS_PSY k59_266380_1 1122997.AUDD01000007_gene810 1.5e-41 149.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K03497,ko:K07316 - - - - ko00000,ko01000,ko02048,ko03000,ko03036,ko04812 - - - N6_N4_Mtase,ParBc k59_222264_1 411467.BACCAP_01659 3.68e-37 144.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,268GS@186813|unclassified Clostridiales 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_184168_1 1323663.AROI01000027_gene1633 3.36e-14 71.6 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,1RZSJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_170602_1 113355.CM001775_gene1099 8.42e-07 52.4 COG0863@1|root,COG0863@2|Bacteria,1G911@1117|Cyanobacteria 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_170604_1 1265503.KB905168_gene1457 2.37e-11 65.9 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,2Q7PN@267889|Colwelliaceae 1236|Gammaproteobacteria L Arm DNA-binding domain intA GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0008979,GO:0009009,GO:0009987,GO:0015074,GO:0016032,GO:0019012,GO:0019015,GO:0019038,GO:0019042,GO:0019043,GO:0019045,GO:0019046,GO:0032359,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044423,GO:0046483,GO:0051704,GO:0071704,GO:0075713,GO:0090304,GO:0140097,GO:1901360 - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_266384_1 388051.AUFE01000035_gene4020 2.01e-35 135.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_266389_2 1173023.KE650771_gene5296 1.44e-06 51.6 COG3628@1|root,COG3628@2|Bacteria,1G6R3@1117|Cyanobacteria 1117|Cyanobacteria S GPW gp25 family protein - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_322708_3 402612.FP0810 1.41e-45 154.0 COG3023@1|root,COG3023@2|Bacteria,4NQ2J@976|Bacteroidetes,1I3X8@117743|Flavobacteriia,2NXVJ@237|Flavobacterium 976|Bacteroidetes V N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_170619_2 478749.BRYFOR_08524 7.25e-37 137.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Terminase_1 k59_306482_1 1121887.AUDK01000004_gene334 1.03e-72 228.0 COG0668@1|root,COG0668@2|Bacteria,4NH7C@976|Bacteroidetes,1ICX5@117743|Flavobacteriia,2NVTM@237|Flavobacterium 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_116472_1 1122201.AUAZ01000017_gene2960 2.41e-181 520.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_222291_1 1122998.AUHZ01000011_gene560 8.74e-30 127.0 COG0584@1|root,COG0584@2|Bacteria 2|Bacteria C glycerophosphodiester phosphodiesterase activity - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_332343_2 1692256.A0A0K1RL54_9CIRC 5.51e-30 121.0 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_49744_1 1465751.W8R9R3_9VIRU 1.47e-42 141.0 4QH3B@10239|Viruses,4QV07@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_323033_2 504832.OCAR_5597 8.58e-07 49.7 COG5004@1|root,COG5004@2|Bacteria 2|Bacteria U Tail protein X - - - - - - - - - - - Phage_tail_X k59_23380_2 1380391.JIAS01000005_gene2454 3.11e-13 78.6 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_372854_1 557598.LHK_01757 2.34e-16 86.7 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2VNJC@28216|Betaproteobacteria,2KPHE@206351|Neisseriales 206351|Neisseriales O Putative phage tail protein - - - - - - - - - - - - CBM_4_9,DUF1983,Phage-tail_3 k59_25210_2 1232430.CAVG010000078_gene724 3.08e-09 56.6 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - 3.6.4.12 ko:K02316,ko:K17680 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03029,ko03032 - - - DUF3991,DnaB_C,Toprim_2,Toprim_3,zf-CHC2 k59_132747_1 688245.CtCNB1_3555 9.89e-23 97.8 COG5301@1|root,COG5301@2|Bacteria,1PG83@1224|Proteobacteria,2WBY1@28216|Betaproteobacteria,4AIIK@80864|Comamonadaceae 28216|Betaproteobacteria UW Hep Hag repeat protein - - - - - - - - - - - - - k59_295358_1 691965.D4P7E6_9CAUD 8.97e-12 73.6 4QAK6@10239|Viruses,4R01K@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_25224_1 1986029.Q9MBM8_9VIRU 5.83e-25 103.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_132754_2 751945.Theos_1690 9.66e-47 162.0 2CHRY@1|root,30Z9E@2|Bacteria,1WN8T@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus - - - - - - - - - - - - - - - k59_186172_1 438753.AZC_0843 7.43e-71 226.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2U265@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_51970_1 322855.Q52PN4_9CAUD 5.27e-34 136.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_401524_2 1151122.AQYD01000006_gene1759 1.68e-10 64.7 COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4FKWD@85023|Microbacteriaceae 201174|Actinobacteria S Fibronectin type 3 domain - - - - - - - - - - - - - k59_401528_1 1026955.F5B3P3_9CAUD 2.16e-31 121.0 4QJCH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_39099_3 428125.CLOLEP_01422 1.64e-22 114.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,3WN92@541000|Ruminococcaceae 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_200325_1 665942.HMPREF1022_02921 3.77e-29 116.0 28W6R@1|root,2ZI7D@2|Bacteria,1N49N@1224|Proteobacteria,431A7@68525|delta/epsilon subdivisions,2WWPT@28221|Deltaproteobacteria,2M9A2@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_309056_1 753084.F4YCI4_9CAUD 7.15e-71 224.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QS4V@28883|Caudovirales,4QKNC@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_254130_1 484018.BACPLE_00805 8.16e-08 60.8 2EVUA@1|root,33P81@2|Bacteria,4P82D@976|Bacteroidetes,2FV68@200643|Bacteroidia,4AU6A@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_161113_2 1121101.HMPREF1532_02778 7.53e-08 57.8 COG0863@1|root,COG0863@2|Bacteria,4NK2X@976|Bacteroidetes,2FPTJ@200643|Bacteroidia,4AS8F@815|Bacteroidaceae 976|Bacteroidetes L DNA methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,SNase k59_200694_1 1226322.HMPREF1545_00787 1.7e-07 59.3 2F01Z@1|root,33T5S@2|Bacteria,1V42D@1239|Firmicutes,24HTR@186801|Clostridia,2N7YV@216572|Oscillospiraceae 186801|Clostridia - - - - - - - - - - - - - - - k59_11401_1 243231.GSU0630 0.000825 46.6 COG0500@1|root,COG2226@2|Bacteria,1N73D@1224|Proteobacteria,42XDU@68525|delta/epsilon subdivisions,2WRMM@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_106359_1 643648.Slip_1015 9.65e-17 79.3 COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,42K5I@68298|Syntrophomonadaceae 186801|Clostridia F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_374534_4 411459.RUMOBE_01753 1.71e-06 50.8 2C6KN@1|root,32Y69@2|Bacteria,1VANX@1239|Firmicutes,24MNG@186801|Clostridia 186801|Clostridia S VRR-NUC domain - - - - - - - - - - - - VRR_NUC k59_334181_1 1609634.A0A0C5AFV4_9VIRU 1.14e-34 135.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_283437_1 691965.D4P7I3_9CAUD 1.04e-89 296.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_323865_1 1038860.AXAP01000015_gene2003 5.23e-12 71.6 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_121574_1 634956.Geoth_0787 1.53e-07 58.2 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,4HCI7@91061|Bacilli,1WG7G@129337|Geobacillus 91061|Bacilli S Phage portal protein - - - - - - - - - - - - Phage_portal k59_377919_2 1537917.JU82_06570 8.52e-30 114.0 2CGG9@1|root,2ZVSJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_310784_1 242861.Q6UYH1_9CAUD 1.35e-13 71.6 4QB07@10239|Viruses,4QUZW@35237|dsDNA viruses no RNA stage,4QPGS@28883|Caudovirales,4QMBY@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF4326) - - - - - - - - - - - - - k59_202892_1 948071.S4S2D9_9CAUD 1.68e-70 238.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_202892_9 1465751.W8QMX2_9VIRU 2.98e-12 63.2 4QGEE@10239|Viruses,4QVDJ@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_13832_1 91464.S7335_1186 8.66e-52 176.0 2CC4J@1|root,2Z7W8@2|Bacteria,1G4C9@1117|Cyanobacteria 1117|Cyanobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_364570_3 675635.Psed_1230 3.6e-59 200.0 COG0175@1|root,COG0175@2|Bacteria,2IBEQ@201174|Actinobacteria,4E8RB@85010|Pseudonocardiales 201174|Actinobacteria EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_243167_2 68219.JNXI01000031_gene5502 1.46e-74 257.0 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_135237_1 1327981.S0A1R5_9CAUD 9.91e-17 89.4 4QGUS@10239|Viruses,4QX38@35237|dsDNA viruses no RNA stage,4QRVV@28883|Caudovirales,4QN8J@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_94812_1 10689.H9C0A7_BPCPT 2.03e-46 169.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_202905_1 1515615.HQ41_08855 3.17e-43 144.0 COG0720@1|root,COG0720@2|Bacteria,4PIUG@976|Bacteroidetes,2FSF1@200643|Bacteroidia,22Z05@171551|Porphyromonadaceae 976|Bacteroidetes H 6-pyruvoyl tetrahydrobiopterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_202905_2 536232.CLM_1798 1.27e-17 81.3 COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,36DMD@31979|Clostridiaceae 186801|Clostridia F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_270142_1 573061.Clocel_3562 8.01e-24 102.0 COG1032@1|root,COG1032@2|Bacteria,1TRY3@1239|Firmicutes,249Q1@186801|Clostridia,36HCS@31979|Clostridiaceae 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_256697_3 1249480.B649_05660 0.000196 45.4 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2YMMT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_163286_49 1121472.AQWN01000003_gene1596 1.79e-11 71.2 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,260PK@186807|Peptococcaceae 186801|Clostridia D Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_244637_1 262724.TT_C0657 7.69e-25 108.0 COG1846@1|root,COG1846@2|Bacteria,1WJ5A@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Transcriptional regulator - - - - - - - - - - - - - k59_325751_1 1220589.CD32_09085 8e-07 56.6 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,4HCJE@91061|Bacilli,3J09N@400634|Lysinibacillus 91061|Bacilli GM Male sterility protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GAF_3,GDP_Man_Dehyd k59_123023_1 326424.FRAAL6628 4.77e-09 65.5 COG1361@1|root,COG3468@1|root,COG4719@1|root,COG1361@2|Bacteria,COG3468@2|Bacteria,COG4719@2|Bacteria,2I8F1@201174|Actinobacteria 201174|Actinobacteria M cellulase activity - - - - - - - - - - - - DUF11,He_PIG,fn3 k59_271271_1 942016.E9NIH0_9CAUD 5.86e-56 195.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_419596_2 153721.MYP_1637 1.13e-23 96.7 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,47QZT@768503|Cytophagia 976|Bacteroidetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_325759_1 10228.TriadP52877 2.21e-12 72.0 2D04N@1|root,2SCSW@2759|Eukaryota,3AE35@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - - k59_217123_1 525146.Ddes_2235 9.38e-22 106.0 COG3378@1|root,COG3378@2|Bacteria,1PDTD@1224|Proteobacteria,42TSY@68525|delta/epsilon subdivisions,2WV92@28221|Deltaproteobacteria,2M9V8@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage plasmid primase P4 family - - - - - - - - - - - - - k59_392918_8 1392490.JHZX01000001_gene2437 1.89e-90 266.0 COG3409@1|root,COG3409@2|Bacteria,4NT07@976|Bacteroidetes,1I8V1@117743|Flavobacteriia 976|Bacteroidetes M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_285045_1 1128421.JAGA01000002_gene516 5.31e-47 161.0 COG1351@1|root,COG1351@2|Bacteria,2NPQ2@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - HNH,Thy1 k59_341406_1 10855.CAPSD_SPV4 1.49e-11 64.7 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_206248_2 536232.CLM_2670 2.05e-261 751.0 COG5545@1|root,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,2495S@186801|Clostridia,36EHX@31979|Clostridiaceae 186801|Clostridia S virulence-associated E family protein - - - - - - - - - - - - VirE k59_206248_3 394503.Ccel_3056 1.01e-18 80.1 2E38J@1|root,32Y88@2|Bacteria,1VAXK@1239|Firmicutes,24N7K@186801|Clostridia,36M6F@31979|Clostridiaceae 186801|Clostridia S VRR-NUC domain-containing protein - - - - - - - - - - - - VRR_NUC k59_206248_4 202752.JL53_00730 7.53e-167 484.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli,26MKQ@186820|Listeriaceae 91061|Bacilli L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_164831_1 1280692.AUJL01000044_gene2346 2.47e-66 217.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,24DVA@186801|Clostridia,36FNM@31979|Clostridiaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_178439_1 1089552.KI911559_gene3374 1.01e-97 294.0 28HS3@1|root,2Z7ZE@2|Bacteria,1QH9A@1224|Proteobacteria,2TVB0@28211|Alphaproteobacteria,2JPPD@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_259550_2 753085.F4YCR7_9CAUD 1.47e-31 125.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_206259_2 352165.HMPREF7215_2555 6.23e-28 106.0 COG3023@1|root,COG3023@2|Bacteria 2|Bacteria V N-Acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_354669_1 663278.Ethha_2000 3.97e-38 140.0 COG0463@1|root,COG0463@2|Bacteria,1V0Q2@1239|Firmicutes,258UI@186801|Clostridia,3WNR8@541000|Ruminococcaceae 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_3184_1 1007869.M9MUG1_9CAUD 4.37e-10 64.3 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_3184_2 1304865.JAGF01000001_gene2648 9.03e-08 59.3 COG2843@1|root,COG2843@2|Bacteria,2GP72@201174|Actinobacteria 201174|Actinobacteria M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_315052_1 1435051.BMOU_0768 5.35e-17 89.0 COG0840@1|root,COG3953@1|root,COG5412@1|root,COG0840@2|Bacteria,COG3953@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,4CZ1P@85004|Bifidobacteriales 201174|Actinobacteria NT phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail k59_259811_1 1041142.ATTP01000021_gene187 3.41e-33 138.0 COG2268@1|root,COG2268@2|Bacteria,1NT13@1224|Proteobacteria,2U335@28211|Alphaproteobacteria,4BCZZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Band 7 protein - - - - - - - - - - - - - k59_139229_3 264462.Bd2734 3.27e-07 58.2 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - Big_5,CHU_C,DUF642,Haemagg_act,SprB k59_74207_1 1279017.AQYJ01000026_gene6 2.39e-24 97.4 COG3108@1|root,COG3108@2|Bacteria,1NMU6@1224|Proteobacteria 1224|Proteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_32435_1 1038860.AXAP01000015_gene2003 3.84e-35 138.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_329216_2 1545701.LACWKB10_0717 2.6e-25 111.0 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity - - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_208587_1 1122201.AUAZ01000017_gene2950 7.04e-97 297.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria,46BED@72275|Alteromonadaceae 1236|Gammaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_153564_1 1172188.KB911820_gene2847 5.25e-183 532.0 COG3567@1|root,COG3567@2|Bacteria,2H48H@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_32712_1 1327974.R9ZXF5_9CAUD 5.42e-12 70.9 4QGWR@10239|Viruses,4QXTA@35237|dsDNA viruses no RNA stage,4QPSG@28883|Caudovirales,4QMZN@10699|Siphoviridae 10699|Siphoviridae S Phage terminase large subunit - - - - - - - - - - - - - k59_274131_4 1229909.NSED_03750 2.03e-08 64.7 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_32717_1 1038860.AXAP01000015_gene2003 2.51e-25 108.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_86973_1 1396418.BATQ01000104_gene5465 0.000409 49.7 COG0210@1|root,COG0210@2|Bacteria,46S8H@74201|Verrucomicrobia,2ITJF@203494|Verrucomicrobiae 203494|Verrucomicrobiae L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_357193_1 443143.GM18_1541 1.02e-12 72.0 COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions,2WT5K@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_C,PKD,Pur_ac_phosph_N k59_125817_1 573061.Clocel_0761 1.94e-18 95.5 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,36EDD@31979|Clostridiaceae 186801|Clostridia L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_45397_1 530564.Psta_0658 5.97e-43 160.0 COG5362@1|root,COG5362@2|Bacteria,2J0FK@203682|Planctomycetes 203682|Planctomycetes S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_99912_1 426355.Mrad2831_5695 7.4e-47 170.0 COG3170@1|root,COG3170@2|Bacteria,1R69E@1224|Proteobacteria,2U3B9@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - - k59_153589_1 1327981.S0A1R5_9CAUD 1.06e-46 175.0 4QGUS@10239|Viruses,4QX38@35237|dsDNA viruses no RNA stage,4QRVV@28883|Caudovirales,4QN8J@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_359808_1 641491.DND132_2087 4.03e-79 253.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions,2WQN3@28221|Deltaproteobacteria,2M90K@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_20806_1 1100720.ALKN01000018_gene1739 8.73e-46 162.0 28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,2VNFP@28216|Betaproteobacteria,4A9TU@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_370873_1 1609634.A0A0C5AFV4_9VIRU 7.03e-35 134.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_276042_1 388051.AUFE01000035_gene4020 9.7e-68 219.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_89381_1 349521.HCH_00067 6.92e-57 193.0 COG0330@1|root,COG0330@2|Bacteria,1R93I@1224|Proteobacteria,1RPTI@1236|Gammaproteobacteria,1XINU@135619|Oceanospirillales 135619|Oceanospirillales O SPFH domain / Band 7 family - - - - - - - - - - - - Band_7 k59_276045_1 1244869.H261_03393 1.44e-19 92.4 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2TVMB@28211|Alphaproteobacteria,2JS1E@204441|Rhodospirillales 204441|Rhodospirillales S COG4422 Bacteriophage protein gp37 - - - - - - - - - - - - DUF5131 k59_319902_1 1458697.W6EKG4_9CAUD 1.3e-06 57.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QM2K@10699|Siphoviridae 10699|Siphoviridae S Phage Tail Collar Domain - - - - - - - - - - - - - k59_127544_3 1122201.AUAZ01000017_gene2960 4.16e-81 257.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_264205_1 316058.RPB_3873 5.75e-39 134.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,2VG5E@28211|Alphaproteobacteria,3JZWG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H PFAM 6-pyruvoyl tetrahydropterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_359838_1 1217718.ALOU01000098_gene4255 2.14e-15 81.3 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,1K152@119060|Burkholderiaceae 28216|Betaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_114463_1 1120941.AUBL01000059_gene872 3.14e-89 272.0 2BVU5@1|root,2Z9FH@2|Bacteria,2HZF5@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_127552_1 857293.CAAU_0191 3.49e-21 91.3 28JU3@1|root,2Z9J6@2|Bacteria,1UZKS@1239|Firmicutes,24AFF@186801|Clostridia,36SC8@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_77931_1 1089544.KB912942_gene1126 4.63e-05 55.1 COG0507@1|root,COG0507@2|Bacteria,2ICMW@201174|Actinobacteria 201174|Actinobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_397816_1 641526.ADIWIN_3940 8.42e-21 100.0 COG0208@1|root,COG0208@2|Bacteria,4NGDD@976|Bacteroidetes,1HY1Y@117743|Flavobacteriia 976|Bacteroidetes F Ribonucleotide Reductase nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_sm k59_80183_3 1096546.WYO_0205 4.05e-24 97.4 COG0647@1|root,COG0647@2|Bacteria 2|Bacteria G UMP catabolic process nagD - 2.7.1.25,3.1.3.41 ko:K00860,ko:K01101 ko00230,ko00627,ko00920,ko01100,ko01120,map00230,map00627,map00920,map01100,map01120 M00176 R00509,R03024,R04928 RC00002,RC00078,RC00151 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_6,Hydrolase_like k59_332116_2 1089552.KI911559_gene1719 1.72e-16 87.8 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2JPRR@204441|Rhodospirillales 204441|Rhodospirillales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_332116_3 765910.MARPU_05650 0.000836 44.3 COG3756@1|root,COG3756@2|Bacteria,1N7G4@1224|Proteobacteria,1SEVU@1236|Gammaproteobacteria,1WZ8D@135613|Chromatiales 135613|Chromatiales S Protein conserved in bacteria - - - - - - - - - - - - - k59_332116_14 1235799.C818_02266 2.04e-17 89.4 28HEE@1|root,2Z7QU@2|Bacteria,1TVQR@1239|Firmicutes,248QB@186801|Clostridia,27KNX@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_116139_2 645099.MREP_BBTVA 7e-18 89.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_91407_7 483219.LILAB_17930 1.45e-18 90.9 COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YXZG@29|Myxococcales 28221|Deltaproteobacteria L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_91407_10 357809.Cphy_2803 6.73e-11 73.9 COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,21Y5F@1506553|Lachnoclostridium 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_8927_1 1123269.NX02_04480 5.55e-06 55.5 COG1280@1|root,COG1280@2|Bacteria,1R2AA@1224|Proteobacteria,2TZEP@28211|Alphaproteobacteria,2KESJ@204457|Sphingomonadales 204457|Sphingomonadales E phage tail tape measure protein - - - - - - - - - - - - - k59_170440_2 716928.AJQT01000109_gene1216 4.8e-27 115.0 2A70H@1|root,30VVP@2|Bacteria,1NFHJ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_294772_1 6326.BUX.s01653.128 5.83e-10 60.5 COG1813@1|root,KOG3398@2759|Eukaryota,3A1NN@33154|Opisthokonta,3BPD8@33208|Metazoa,3CWT3@33213|Bilateria,40DAP@6231|Nematoda,1KVQI@119089|Chromadorea 33208|Metazoa K Helix-turn-helix XRE-family like proteins EDF1 GO:0003158,GO:0003674,GO:0003712,GO:0003713,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007275,GO:0007399,GO:0007417,GO:0007424,GO:0008150,GO:0009888,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019216,GO:0019219,GO:0019222,GO:0030154,GO:0030674,GO:0030855,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043388,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045446,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048522,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060090,GO:0060255,GO:0060429,GO:0060541,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03627 - - - - ko00000 - - - HTH_3,MBF1 k59_268407_1 644968.DFW101_3522 3.21e-106 326.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,42QKN@68525|delta/epsilon subdivisions,2WK3R@28221|Deltaproteobacteria,2MA6M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_385877_1 1408428.JNJP01000030_gene963 1.03e-59 201.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions,2WQN3@28221|Deltaproteobacteria,2M90K@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_416140_1 1264700.L0MX86_9CAUD 4.58e-39 155.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QJW9@10662|Myoviridae 10662|Myoviridae S nucleic acid binding - - - - - - - - - - - - - k59_93508_1 1265502.KB905977_gene528 9.64e-32 118.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,4AIQ3@80864|Comamonadaceae 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_253664_1 691965.D4P7L7_9CAUD 6.77e-42 157.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_401366_1 1321782.HMPREF1986_02255 5.74e-21 95.9 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,2PRYV@265975|Oribacterium 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - SNF2_N k59_105890_2 272942.RCAP_rcc01080 2.64e-13 73.6 2CZBU@1|root,32T60@2|Bacteria,1N7TC@1224|Proteobacteria,2UIQ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_51784_1 310539.Q5G7M7_9CAUD 2.4e-20 99.8 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_25079_1 208439.AJAP_28090 2.14e-52 184.0 COG4626@1|root,COG4626@2|Bacteria,2GNSB@201174|Actinobacteria,4E2Y5@85010|Pseudonocardiales 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_385893_1 1250232.JQNJ01000001_gene2876 4.59e-22 99.0 COG4886@1|root,COG4886@2|Bacteria,4P4WY@976|Bacteroidetes,1IKTM@117743|Flavobacteriia 976|Bacteroidetes U Leucine rich repeats (6 copies) - - - - - - - - - - - - DUF4988,LRR_5 k59_268445_1 113370.Q0E515_SFAVA 7.12e-19 86.7 4QFN9@10239|Viruses,4QYW9@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_240882_2 105154.Q9MBU6_9VIRU 7.18e-15 74.3 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_240888_1 292414.TM1040_0821 3.65e-19 92.4 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K12287 - - - - ko00000,ko02044 - - - DUF11,VCBS k59_389043_1 765912.Thimo_0605 3.18e-07 62.4 COG0028@1|root,COG0028@2|Bacteria 2|Bacteria EH Belongs to the TPP enzyme family - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3 k59_240902_1 525373.HMPREF0766_12456 2.65e-73 228.0 COG0863@1|root,COG0863@2|Bacteria,4NQQ1@976|Bacteroidetes 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_389123_1 1204521.I6ZXZ4_9CAUD 4.89e-44 157.0 4QHBE@10239|Viruses,4QT2W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_240967_1 686340.Metal_3113 0.000448 52.4 COG3291@1|root,COG3291@2|Bacteria,1R7A1@1224|Proteobacteria,1S0A9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S IgGFc binding protein - - - - - - - - - - - - IgGFc_binding k59_228401_2 1618249.A0A0C5IBT4_9CIRC 4.45e-31 117.0 4QB6C@10239|Viruses,4QUKM@29258|ssDNA viruses 10239|Viruses J Geminivirus Rep catalytic domain - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051701,GO:0051704 - - - - - - - - - - - k59_430817_1 1618247.A0A0C5IMK7_9CIRC 1.45e-05 52.0 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_430822_1 1379715.S5TMW6_9CIRC 3.93e-52 179.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_389197_1 1692249.A0A0K1RL40_9CIRC 8.16e-47 160.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_189080_1 1618240.A0A0C5IMJ1_9CIRC 4.15e-107 315.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_364437_2 2754.EH55_11985 1e-21 90.9 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_175534_5 596154.Alide2_3062 4.44e-54 186.0 COG5377@1|root,COG5377@2|Bacteria,1MWP8@1224|Proteobacteria,2VJH5@28216|Betaproteobacteria,4ADEW@80864|Comamonadaceae 28216|Betaproteobacteria L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_419568_9 321846.PS417_10075 2.04e-87 280.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1RMTH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_163286_8 1151126.AQYI01000003_gene390 8.58e-28 124.0 COG0553@1|root,COG0553@2|Bacteria,2IG91@201174|Actinobacteria,4FR82@85023|Microbacteriaceae 201174|Actinobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_163286_14 862517.HMPREF9225_1738 1.34e-35 152.0 COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,22GDR@1570339|Peptoniphilaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1865_2 398578.Daci_1943 9.09e-36 142.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria 1224|Proteobacteria M Membrane - - - - - - - - - - - - - k59_83205_1 762982.HMPREF9442_01223 1.41e-86 270.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia 976|Bacteroidetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_109711_1 1611039.A0A0C5C3Z3_9CIRC 4.52e-49 167.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_123092_1 1331060.RLDS_16020 7.19e-45 166.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,2K42P@204457|Sphingomonadales 204457|Sphingomonadales S Terminase - - - - - - - - - - - - Terminase_1 k59_123092_2 1038860.AXAP01000015_gene2003 9.14e-95 318.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,3K0XM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_123092_4 1506583.JQJY01000003_gene3401 4.95e-13 79.0 COG4695@1|root,COG4695@2|Bacteria,4NT34@976|Bacteroidetes 976|Bacteroidetes S Phage portal protein - - - - - - - - - - - - Phage_portal k59_123092_10 234267.Acid_6164 2.46e-33 150.0 COG0823@1|root,COG2374@1|root,COG3170@1|root,COG3291@1|root,COG3391@1|root,COG3867@1|root,COG4257@1|root,COG4625@1|root,COG0823@2|Bacteria,COG2374@2|Bacteria,COG3170@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3867@2|Bacteria,COG4257@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria 2|Bacteria M PKD domain containing protein - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.2.1.4 ko:K01179,ko:K07004,ko:K13277,ko:K20276,ko:K21449 ko00500,ko01100,ko02024,map00500,map01100,map02024 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko02000,ko03110 1.B.40.2 GH5,GH9 - Big_3_2,Exo_endo_phos,He_PIG,LTD k59_123092_18 1121861.KB899916_gene1631 1.46e-21 109.0 COG3941@1|root,COG5281@1|root,COG3941@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2U3WK@28211|Alphaproteobacteria,2JTUX@204441|Rhodospirillales 204441|Rhodospirillales D tape measure protein - - - - - - - - - - - - - k59_123092_20 1125863.JAFN01000001_gene3560 1.39e-17 82.0 2E5ZV@1|root,330P8@2|Bacteria,1NFRE@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_123092_21 744980.TRICHSKD4_2426 1.61e-21 90.5 COG0791@1|root,COG0791@2|Bacteria 2|Bacteria M cysteine-type peptidase activity - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - LysM,NLPC_P60 k59_123092_22 114615.BRADO3646 4.06e-29 136.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,3JW1G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_56291_2 4113.PGSC0003DMT400072853 0.000145 47.8 KOG1584@1|root,KOG1584@2759|Eukaryota,37PH9@33090|Viridiplantae,3G7CA@35493|Streptophyta,44DSP@71274|asterids 35493|Streptophyta H Belongs to the sulfotransferase 1 family - - 2.8.2.39 ko:K01025,ko:K22312 - - - - ko00000,ko01000 - - - Sulfotransfer_1 k59_300026_1 665942.HMPREF1022_02940 2.18e-31 126.0 COG0553@1|root,COG0827@1|root,COG1040@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG1040@2|Bacteria,COG4646@2|Bacteria,1PGZG@1224|Proteobacteria,42NYW@68525|delta/epsilon subdivisions 1224|Proteobacteria L COG0827 Adenine-specific DNA methylase - - - - - - - - - - - - Eco57I,Helicase_C,N6_Mtase,ResIII,SNF2_N k59_300027_1 10754.VG16_BPP22 1.61e-19 96.3 4QEN7@10239|Viruses,4QW0U@35237|dsDNA viruses no RNA stage,4QSNP@28883|Caudovirales,4QNFM@10744|Podoviridae 10744|Podoviridae S viral entry into host cell - GO:0006810,GO:0008150,GO:0016032,GO:0019058,GO:0030260,GO:0039678,GO:0044403,GO:0044409,GO:0044419,GO:0044766,GO:0046718,GO:0046794,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0099002,GO:1902579 - - - - - - - - - - - k59_206633_3 29875.EHK19034 2.46e-06 55.5 2EEPU@1|root,2SK24@2759|Eukaryota,39XQC@33154|Opisthokonta,3NXM7@4751|Fungi,3QM42@4890|Ascomycota,2117A@147550|Sordariomycetes,3TKIC@5125|Hypocreales 4751|Fungi S Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_165221_2 1122614.JHZF01000011_gene1718 3.08e-10 59.7 2C7JB@1|root,2ZXVG@2|Bacteria,1P7GB@1224|Proteobacteria,2UYPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_380581_2 342610.Patl_3555 1.3e-41 143.0 COG0741@1|root,COG0741@2|Bacteria,1QZ7X@1224|Proteobacteria,1T417@1236|Gammaproteobacteria 1236|Gammaproteobacteria M lytic transglycosylase activity - - - - - - - - - - - - - k59_231989_1 1122614.JHZF01000011_gene1727 4.93e-18 79.3 2E30K@1|root,32Y13@2|Bacteria,1N8M1@1224|Proteobacteria,2UFCW@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_178863_1 1123257.AUFV01000013_gene2785 5.68e-38 139.0 COG0863@1|root,COG0863@2|Bacteria,1PCSE@1224|Proteobacteria,1SARI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_85116_1 391615.ABSJ01000015_gene1589 7.98e-11 61.6 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_192119_1 1517416.IDAT_01035 1.78e-38 147.0 2CEG2@1|root,2ZCEX@2|Bacteria,1RB74@1224|Proteobacteria,1S2JC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage replication protein CRI - - - - - - - - - - - - Phage_CRI,Phage_X k59_30890_1 1117943.SFHH103_01661 5.84e-25 112.0 COG4653@1|root,COG4653@2|Bacteria,1MYMH@1224|Proteobacteria,2TUSK@28211|Alphaproteobacteria,4BDCP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Major capsid protein - - - - - - - - - - - - Phage_capsid k59_355037_2 77856.REP_BFDV 8.74e-41 150.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_165232_5 1538804.A0A088F6N3_9CAUD 2e-17 80.1 4QFW7@10239|Viruses,4QU0S@28883|Caudovirales,4QM9S@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_151914_1 105154.Q9MBU6_9VIRU 1.37e-69 228.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_286519_1 1136535.I6NVP1_9CAUD 8.59e-16 83.2 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_206654_4 1236518.BAKP01000063_gene2538 3.76e-07 60.8 COG0507@1|root,COG0507@2|Bacteria,4NDYK@976|Bacteroidetes,2FNT1@200643|Bacteroidia 976|Bacteroidetes L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member - - - - - - - - - - - - AAA_30,UvrD_C_2 k59_30914_2 243090.RB3598 7.43e-15 79.0 COG1570@1|root,COG1570@2|Bacteria,2IXGG@203682|Planctomycetes 203682|Planctomycetes L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_98100_6 335543.Sfum_3184 5.68e-21 100.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_329750_8 580331.Thit_0474 8.45e-12 61.6 COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,24QPD@186801|Clostridia,42HH9@68295|Thermoanaerobacterales 186801|Clostridia T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_329750_11 1501230.ET33_26555 1.22e-15 74.3 COG1694@1|root,COG1694@2|Bacteria,1VG7F@1239|Firmicutes,4HWVH@91061|Bacilli,26ZEB@186822|Paenibacillaceae 91061|Bacilli S Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG k59_396328_1 1121946.AUAX01000040_gene5607 1.22e-07 54.3 COG0494@1|root,COG0494@2|Bacteria,2II0E@201174|Actinobacteria,4DENQ@85008|Micromonosporales 201174|Actinobacteria L nUDIX hydrolase - - - - - - - - - - - - - k59_194089_1 1166018.FAES_1804 1.68e-19 95.5 2DSC5@1|root,33FGD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_382095_1 1121430.JMLG01000007_gene2516 6.08e-17 88.2 COG3598@1|root,COG3598@2|Bacteria,1UJSF@1239|Firmicutes,25F8S@186801|Clostridia,263X1@186807|Peptococcaceae 186801|Clostridia L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - PriCT_1,Prim-Pol k59_382095_2 1314.HKU360_01502 5.36e-29 128.0 COG3378@1|root,COG5545@1|root,COG3378@2|Bacteria,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,4HCHZ@91061|Bacilli 91061|Bacilli T Virulence-associated protein E - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5,VirE k59_113123_1 994479.GL877878_gene3344 6.37e-12 74.7 COG3941@1|root,COG3953@1|root,COG5412@1|root,COG3941@2|Bacteria,COG3953@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria,4E86P@85010|Pseudonocardiales 201174|Actinobacteria M phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail,SLT k59_75311_1 1233488.S4T7A5_9CAUD 3.38e-17 81.3 4QD6D@10239|Viruses,4QZFH@35237|dsDNA viruses no RNA stage,4QUDK@28883|Caudovirales,4QP43@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_126200_1 926564.KI911577_gene476 1.43e-20 101.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria 201174|Actinobacteria KT Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail,SLT k59_344425_1 1122228.AQXR01000010_gene1084 1.09e-33 138.0 COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CZAZ@85004|Bifidobacteriales 201174|Actinobacteria M Transglycosylase pon1 - - - - - - - - - - - PASTA,Transgly,Transpeptidase k59_19287_2 260827.Q6R6B5_9CAUD 3.86e-34 142.0 4QESW@10239|Viruses,4QX93@35237|dsDNA viruses no RNA stage,4QQJM@28883|Caudovirales,4QP36@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_410746_1 399795.CtesDRAFT_PD2911 5.34e-27 117.0 COG2304@1|root,COG3209@1|root,COG4733@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,2VJS7@28216|Betaproteobacteria,4AHBA@80864|Comamonadaceae 28216|Betaproteobacteria M Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_344812_1 1618254.A0A0C5IBG4_9CIRC 3.36e-78 241.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_382292_1 411460.RUMTOR_01342 1.63e-48 161.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_382292_3 428125.CLOLEP_01413 1.93e-27 103.0 2E2Y0@1|root,32XYV@2|Bacteria,1VD9S@1239|Firmicutes,24PK0@186801|Clostridia,3WPDR@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_181387_1 349521.HCH_02905 0.000339 48.9 COG1511@1|root,COG1511@2|Bacteria,1QWV3@1224|Proteobacteria,1T42T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tail tape measure protein - - - - - - - - - - - - PhageMin_Tail k59_60040_1 1279009.ADICEAN_02328 9.7e-54 187.0 COG3941@1|root,COG3941@2|Bacteria,4NS30@976|Bacteroidetes 976|Bacteroidetes D tape measure - - - - - - - - - - - - - k59_143155_1 1325372.N0DQU3_9CAUD 2.05e-90 291.0 4QB9Y@10239|Viruses,4QWGZ@35237|dsDNA viruses no RNA stage,4QPTT@28883|Caudovirales,4QJD7@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_369915_1 1795983.A0A140CTJ3_9CIRC 9.81e-14 75.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_344819_1 1380390.JIAT01000014_gene6288 1.89e-18 98.2 COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD k59_75808_5 38033.XP_001223727.1 0.000148 46.2 2CYSS@1|root,2S670@2759|Eukaryota,3ASIZ@33154|Opisthokonta,3Q4MX@4751|Fungi,3RMWP@4890|Ascomycota,217CH@147550|Sordariomycetes,3U6Z2@5139|Sordariales,3HAJ6@35718|Chaetomiaceae 4751|Fungi S Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation - - - ko:K18732 - - - - ko00000,ko03019 - - - SAP k59_347007_2 445973.CLOBAR_01779 4.08e-05 46.2 29UR3@1|root,30G32@2|Bacteria,1UF3V@1239|Firmicutes,25K4N@186801|Clostridia,25UCU@186804|Peptostreptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_78715_2 1236902.ANAS01000022_gene19 1.88e-13 66.2 2CAFG@1|root,32ZDZ@2|Bacteria,2I800@201174|Actinobacteria,4EKB0@85012|Streptosporangiales 201174|Actinobacteria S Protein of unknown function (DUF3039) - - - - - - - - - - - - DUF3039 k59_62125_1 502025.Hoch_1300 6.06e-05 52.4 COG0535@1|root,COG0535@2|Bacteria,1PVRY@1224|Proteobacteria,4380G@68525|delta/epsilon subdivisions,2X9U8@28221|Deltaproteobacteria,2YZH0@29|Myxococcales 28221|Deltaproteobacteria S Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_347280_2 37659.JNLN01000001_gene918 4.74e-14 77.8 COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,36DQQ@31979|Clostridiaceae 186801|Clostridia L DNA replication protein dnaC - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 k59_90414_6 112098.XP_008607965.1 1.33e-49 179.0 COG1372@1|root,2QRRC@2759|Eukaryota 2759|Eukaryota L reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Ribonuc_red_lgC k59_265250_3 1346791.M529_02355 9.83e-65 212.0 COG0175@1|root,COG0175@2|Bacteria,1QZJ1@1224|Proteobacteria,2U233@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_90416_1 1173762.S4TP25_9CAUD 1.11e-50 182.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_79122_1 1692253.A0A0K1RLM4_9CIRC 2.39e-22 103.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_290949_2 945021.TEH_18310 9.76e-14 73.2 2DR9Y@1|root,33AUY@2|Bacteria,1VEP1@1239|Firmicutes,4HIWW@91061|Bacilli,4B4BW@81852|Enterococcaceae 91061|Bacilli L NUMOD4 motif - - - - - - - - - - - - HNH_3,NUMOD4 k59_413135_1 1609634.A0A0C5ANA6_9VIRU 1.7e-13 71.6 4QCA6@10239|Viruses,4QUMI@29258|ssDNA viruses,4QP4E@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_413135_2 1385658.U5KPZ6_9VIRU 6.78e-161 476.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_413135_4 1165094.RINTHH_3920 6.72e-66 216.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_347306_1 411473.RUMCAL_00286 1.3e-46 159.0 COG0270@1|root,COG0270@2|Bacteria,1VSZI@1239|Firmicutes,24YBG@186801|Clostridia 186801|Clostridia L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_297298_1 691965.D4P7I0_9CAUD 7.81e-32 122.0 4QDSZ@10239|Viruses,4QXJ8@35237|dsDNA viruses no RNA stage,4QPKE@28883|Caudovirales,4QM8R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_391717_1 582899.Hden_1166 4e-107 316.0 COG0175@1|root,COG0175@2|Bacteria,1R52W@1224|Proteobacteria,2U0Y4@28211|Alphaproteobacteria,3N7GH@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria EH COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes - - - - - - - - - - - - PAPS_reduct k59_189288_2 537007.BLAHAN_04313 1.6e-24 114.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3XYP7@572511|Blautia 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_337745_1 1379725.S5TMY9_9CIRC 8.9e-20 93.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_108407_1 1116472.MGMO_218c00030 5.18e-165 467.0 COG1609@1|root,COG1609@2|Bacteria,1MVZ4@1224|Proteobacteria,1RMGU@1236|Gammaproteobacteria 1236|Gammaproteobacteria K binds specific sites in lac operon resulting in DNA looping between the operators lacI GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - LacI,Peripla_BP_3 k59_94980_2 226186.BT_2026 7.09e-10 65.5 2DR9Y@1|root,33AUY@2|Bacteria,4NZ4B@976|Bacteroidetes,2FQRH@200643|Bacteroidia,4APD1@815|Bacteroidaceae 976|Bacteroidetes L HNH endonuclease domain protein - - - - - - - - - - - - HNH_3,NUMOD4 k59_337760_3 740709.A10D4_08077 0.000179 50.1 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,2QF6D@267893|Idiomarinaceae 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_203185_4 1172188.KB911820_gene2845 9.23e-25 98.2 2F5XY@1|root,33YGK@2|Bacteria,2H6A2@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_203185_5 1007869.M9MUF5_9CAUD 1.67e-31 125.0 4QE1G@10239|Viruses,4QWBT@35237|dsDNA viruses no RNA stage,4QS5W@28883|Caudovirales,4QI1P@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_162345_1 742767.HMPREF9456_03236 5.07e-25 109.0 COG1783@1|root,COG1783@2|Bacteria,4NHPB@976|Bacteroidetes,2FR95@200643|Bacteroidia,22WQM@171551|Porphyromonadaceae 976|Bacteroidetes S Terminase RNAseH like domain - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_121832_1 1124655.G9L6H2_9CAUD 8.25e-09 62.0 4QBHS@10239|Viruses,4QUVV@35237|dsDNA viruses no RNA stage,4QPT9@28883|Caudovirales,4QNIE@10744|Podoviridae 10744|Podoviridae S DNA metabolic process - - - - - - - - - - - - - k59_311071_5 742767.HMPREF9456_02357 1.58e-20 90.5 COG4734@1|root,COG4734@2|Bacteria,4NMZR@976|Bacteroidetes,2FNXP@200643|Bacteroidia,22XYU@171551|Porphyromonadaceae 976|Bacteroidetes S Antirestriction protein (ArdA) - - - - - - - - - - - - ArdA k59_311071_7 1460634.JCM19037_4377 2.99e-20 87.8 2DQBA@1|root,335SB@2|Bacteria,1VHD4@1239|Firmicutes,4HPCE@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_324241_1 1216362.B437_07993 1.27e-09 60.1 2E1PK@1|root,32X02@2|Bacteria,37C0R@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF1353) - - - - - - - - - - - - DUF1353 k59_243349_1 1692242.A0A0K1RL37_9CIRC 9.46e-17 85.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_391739_1 663278.Ethha_2190 2.4e-52 187.0 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WJQ5@541000|Ruminococcaceae 186801|Clostridia M Cysteine-rich secretory protein family - - - - - - - - - - - - CAP,LysM k59_137288_7 1185766.DL1_08645 1.13e-41 151.0 COG3756@1|root,COG3756@2|Bacteria,1NGB2@1224|Proteobacteria,2VGAH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_137288_10 343509.SG0727 1.29e-105 317.0 COG0270@1|root,COG0270@2|Bacteria,1NPQG@1224|Proteobacteria,1S07Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_137288_11 1122180.Lokhon_01860 4.31e-27 103.0 2C6KN@1|root,32Y69@2|Bacteria,1N8AV@1224|Proteobacteria,2UKJX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S VRR_NUC - - - - - - - - - - - - VRR_NUC k59_1918_1 1692244.A0A0K1RLR5_9CIRC 1.28e-40 149.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_56315_2 278957.ABEA03000120_gene1205 1.64e-68 226.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities - - 3.6.4.12 ko:K03551,ko:K03924,ko:K04748 ko03440,map03440 - R00294 RC02794 ko00000,ko00001,ko01000,ko03400 3.D.4.10 - - AAA_11,AAA_12,AAA_5,DUF3987,PIN_4 k59_353085_1 1123013.AUIC01000003_gene746 9.76e-80 253.0 COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4FMEX@85023|Microbacteriaceae 201174|Actinobacteria T Large family of predicted nucleotide-binding domains phoH2 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_163566_1 857293.CAAU_0795 4.14e-16 81.3 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,248DP@186801|Clostridia,36GN9@31979|Clostridiaceae 186801|Clostridia S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_339794_2 1033734.CAET01000073_gene2664 1.25e-26 120.0 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4HA1S@91061|Bacilli,1ZAYY@1386|Bacillus 91061|Bacilli D Belongs to the FtsK SpoIIIE SftA family sftA - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE,Ftsk_gamma k59_244887_1 1235559.K4HZG8_9CAUD 2.96e-11 68.2 4QC5D@10239|Viruses,4QVY9@35237|dsDNA viruses no RNA stage,4QPVU@28883|Caudovirales 28883|Caudovirales S Protein of unknown function (DUF2800) - - - - - - - - - - - - - k59_42454_1 742740.HMPREF9474_02279 1.84e-51 169.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,221XY@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_204723_1 1121937.AUHJ01000007_gene1938 1.46e-05 49.3 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria,467NH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_271640_1 529818.AMSG_09125T0 4.89e-23 104.0 COG1793@1|root,KOG0966@2759|Eukaryota 2759|Eukaryota L DNA ligase LIG4 GO:0000012,GO:0000166,GO:0000228,GO:0000723,GO:0000726,GO:0000781,GO:0000784,GO:0000785,GO:0000790,GO:0000793,GO:0001302,GO:0001701,GO:0001775,GO:0002200,GO:0002204,GO:0002208,GO:0002244,GO:0002250,GO:0002252,GO:0002263,GO:0002285,GO:0002312,GO:0002320,GO:0002328,GO:0002366,GO:0002376,GO:0002377,GO:0002381,GO:0002440,GO:0002443,GO:0002449,GO:0002460,GO:0002520,GO:0002521,GO:0002562,GO:0002568,GO:0002681,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005911,GO:0005958,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006289,GO:0006297,GO:0006302,GO:0006303,GO:0006310,GO:0006725,GO:0006807,GO:0006915,GO:0006950,GO:0006955,GO:0006974,GO:0006996,GO:0007275,GO:0007399,GO:0007417,GO:0007568,GO:0007569,GO:0008022,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0008283,GO:0008284,GO:0009314,GO:0009405,GO:0009506,GO:0009628,GO:0009790,GO:0009792,GO:0009987,GO:0010165,GO:0010212,GO:0010332,GO:0010638,GO:0010720,GO:0010941,GO:0012501,GO:0016032,GO:0016043,GO:0016064,GO:0016444,GO:0016445,GO:0016447,GO:0016874,GO:0016886,GO:0017076,GO:0019042,GO:0019043,GO:0019724,GO:0019827,GO:0022008,GO:0030054,GO:0030097,GO:0030098,GO:0030154,GO:0030217,GO:0030447,GO:0030554,GO:0031974,GO:0031981,GO:0032200,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032807,GO:0032991,GO:0033043,GO:0033044,GO:0033077,GO:0033151,GO:0033152,GO:0033153,GO:0033554,GO:0034641,GO:0035019,GO:0035639,GO:0035770,GO:0036094,GO:0036464,GO:0040007,GO:0042110,GO:0042113,GO:0042127,GO:0042592,GO:0042981,GO:0043009,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043523,GO:0043524,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0045190,GO:0045321,GO:0045595,GO:0045597,GO:0046483,GO:0046649,GO:0048046,GO:0048145,GO:0048146,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051102,GO:0051103,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051276,GO:0051402,GO:0051704,GO:0051716,GO:0051960,GO:0051962,GO:0055044,GO:0060249,GO:0060284,GO:0060548,GO:0065007,GO:0065008,GO:0070013,GO:0070419,GO:0070997,GO:0071704,GO:0071840,GO:0075713,GO:0090304,GO:0097159,GO:0097367,GO:0097680,GO:0098687,GO:0098727,GO:0140097,GO:1901214,GO:1901215,GO:1901265,GO:1901360,GO:1901363,GO:1990391,GO:1990904,GO:2000026,GO:2001252 6.2.1.3,6.5.1.1 ko:K01897,ko:K10777,ko:K15201 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko03450,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map03450,map04146,map04216,map04714,map04920 M00086 R00381,R01280 RC00004,RC00005,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko03021,ko03400,ko04147 4.C.1.1 - - BRCT,BRCT_2,DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,DNA_ligase_IV k59_285264_10 1211815.CBYP010000012_gene463 0.000135 48.5 COG2852@1|root,COG2852@2|Bacteria,2GN40@201174|Actinobacteria 201174|Actinobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF559 k59_285264_13 1302286.BAOT01000001_gene129 2.22e-09 58.2 COG1694@1|root,COG1694@2|Bacteria,1VIQA@1239|Firmicutes,4HM6C@91061|Bacilli,3F6WJ@33958|Lactobacillaceae 91061|Bacilli S mazG nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG k59_231052_2 1242969.ATCC51562_1608 8.53e-48 176.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,42UU6@68525|delta/epsilon subdivisions,2YQ2G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_192248_3 1380394.JADL01000008_gene3768 3.13e-89 293.0 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria,2U5NE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - - k59_139648_1 1437882.AZRU01000034_gene466 3.94e-07 50.1 COG1476@1|root,COG1476@2|Bacteria,1QFBF@1224|Proteobacteria,1TCHW@1236|Gammaproteobacteria,1YKCG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_192446_2 1101190.ARWB01000001_gene646 1.71e-13 70.9 2E3EW@1|root,32YDU@2|Bacteria,1NFHT@1224|Proteobacteria,2VGTE@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - Phage_tail_3 k59_17287_1 525257.HMPREF0204_14646 0.000532 52.4 COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,4P2RH@976|Bacteroidetes,1IJJ1@117743|Flavobacteriia,3ZQFH@59732|Chryseobacterium 976|Bacteroidetes S Fibronectin type 3 domain - - - - - - - - - - - - CHU_C,fn3 k59_355462_2 521097.Coch_0880 7.06e-44 160.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,1I7WE@117743|Flavobacteriia,1EQNF@1016|Capnocytophaga 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_31236_9 1385519.N801_02320 1.39e-40 167.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - He_PIG,Peptidase_S8,SLH,fn3 k59_98486_1 717785.HYPMC_2178 1.08e-09 70.9 COG3064@1|root,COG3266@1|root,COG3921@1|root,COG5281@1|root,COG3064@2|Bacteria,COG3266@2|Bacteria,COG3921@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2U3WK@28211|Alphaproteobacteria,3N8N1@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria M tape measure protein - - - - - - - - - - - - Peptidase_M15_4,Tape_meas_lam_C k59_300580_1 1476390.A0A060RFG9_9CAUD 9.34e-18 84.7 4QBA5@10239|Viruses,4QXFW@35237|dsDNA viruses no RNA stage,4QPTU@28883|Caudovirales,4QN4A@10699|Siphoviridae 10699|Siphoviridae S AAA domain - - - - - - - - - - - - - k59_300580_2 756272.Plabr_0198 1.24e-11 65.5 2CEI6@1|root,2ZED5@2|Bacteria,2J3S1@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_72796_2 1429916.X566_20585 6.9e-63 199.0 COG1738@1|root,COG1738@2|Bacteria,1RDSF@1224|Proteobacteria,2U7ZF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_72796_3 1469557.JSWF01000025_gene1296 4.08e-13 69.7 COG0603@1|root,COG0603@2|Bacteria,4PF0R@976|Bacteroidetes,1IADP@117743|Flavobacteriia 976|Bacteroidetes F Queuosine biosynthesis protein QueC - - - - - - - - - - - - QueC k59_152327_1 176652.VF184_IIV6 2.79e-31 129.0 4QAY9@10239|Viruses,4QV7W@35237|dsDNA viruses no RNA stage 10239|Viruses S D5 N terminal like - GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_369593_1 331869.BAL199_17183 6.58e-50 175.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,4BR8D@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_3,Terminase_6,Terminase_6C k59_142723_2 450851.PHZ_c2212 4.69e-48 178.0 COG5323@1|root,COG5323@2|Bacteria,1R0EP@1224|Proteobacteria,2TYQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - - k59_344440_1 1618258.A0A0C5I9K3_9CIRC 2.1e-17 90.1 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_33332_1 1379713.S5SYD9_9CIRC 1.42e-16 79.3 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_113140_1 942016.E9NIH0_9CAUD 5.58e-89 288.0 4QGA5@10239|Viruses,4QURD@35237|dsDNA viruses no RNA stage,4QT9N@28883|Caudovirales,4QP47@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_382110_1 265072.Mfla_0063 9.71e-09 63.5 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,2KM8B@206350|Nitrosomonadales 206350|Nitrosomonadales M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_274560_1 10855.REP_SPV4 1.29e-32 125.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_5383_1 595536.ADVE02000001_gene1129 7.43e-23 98.2 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_329768_1 1123368.AUIS01000006_gene544 3.3e-92 318.0 COG4733@1|root,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,1RRUV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_100583_1 768066.HELO_3154 4.72e-89 281.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XJ5H@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the heme-copper respiratory oxidase family cyoB - 1.10.3.10 ko:K02298 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX1 k59_288449_2 298654.FraEuI1c_0163 0.000624 50.8 2DBVG@1|root,2ZBB1@2|Bacteria,2IH9V@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_219621_1 1609634.A0A0C5AFV4_9VIRU 7.85e-24 100.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_396557_2 472175.EL18_01375 4.65e-42 157.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,43N07@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_167647_1 1122225.AULQ01000009_gene341 8.47e-49 177.0 2EAST@1|root,334US@2|Bacteria,4NRGD@976|Bacteroidetes,1I583@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_5601_2 1401065.HMPREF2130_10705 9.4e-12 73.2 2E8SI@1|root,3333B@2|Bacteria,1N7MG@1224|Proteobacteria,2W67P@28216|Betaproteobacteria,3T896@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_383559_2 948071.S4S2L2_9CAUD 5.51e-06 55.1 4QHQ5@10239|Viruses,4QR7K@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_290373_2 742733.HMPREF9469_05037 9.21e-26 99.8 2BD7A@1|root,326VE@2|Bacteria,1USRB@1239|Firmicutes,25ASG@186801|Clostridia,223BG@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_290373_3 665956.HMPREF1032_00668 7.87e-25 96.7 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia,3WNH7@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_398191_3 359.CN09_11160 1.25e-07 51.6 2DF0N@1|root,2ZQ08@2|Bacteria,1PA3K@1224|Proteobacteria,2UY78@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_7545_2 349161.Dred_1192 6.76e-19 87.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,24DVA@186801|Clostridia 186801|Clostridia L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_78496_1 1618248.A0A0C5IB82_9CIRC 1.21e-14 79.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_371586_2 428125.CLOLEP_01409 3.49e-35 132.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_102787_2 155148.Q9AYZ7_BPHK6 1.65e-30 122.0 4QBD3@10239|Viruses,4QXFU@35237|dsDNA viruses no RNA stage,4QQ7Z@28883|Caudovirales,4QNJ0@10744|Podoviridae 10744|Podoviridae S P22 coat protein - gene protein 5 - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0008150,GO:0009987,GO:0016032,GO:0016043,GO:0019012,GO:0019028,GO:0019030,GO:0019058,GO:0019068,GO:0019069,GO:0019075,GO:0022607,GO:0039620,GO:0042802,GO:0042803,GO:0044085,GO:0044403,GO:0044419,GO:0044423,GO:0046729,GO:0046797,GO:0046983,GO:0051704,GO:0071840 - - - - - - - - - - - k59_412936_1 65672.G4TR60 7.44e-13 73.9 COG3774@1|root,2S433@2759|Eukaryota,39ZV7@33154|Opisthokonta,3P23T@4751|Fungi,3V7MZ@5204|Basidiomycota,22AGX@155619|Agaricomycetes,3H85I@355688|Agaricomycetes incertae sedis 4751|Fungi M Glycosyltransferase sugar-binding region containing DXD motif - - - - - - - - - - - - Gly_transf_sug k59_383760_1 411468.CLOSCI_00540 7.09e-05 50.4 COG5280@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,21YY2@1506553|Lachnoclostridium 186801|Clostridia M Phage tail tape measure protein, TP901 family - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail k59_331461_1 1121459.AQXE01000007_gene744 5.99e-17 84.3 2AHEX@1|root,317S3@2|Bacteria,1PZ4X@1224|Proteobacteria,435QC@68525|delta/epsilon subdivisions,2X9BY@28221|Deltaproteobacteria,2MAH2@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_78851_1 1278073.MYSTI_02897 8.5e-47 171.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_250702_1 1465751.W8QF65_9VIRU 7.23e-141 407.0 4QDXH@10239|Viruses,4QW9Q@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_305009_3 313603.FB2170_07609 1.14e-30 113.0 COG0629@1|root,COG0629@2|Bacteria,4NT9M@976|Bacteroidetes,1I1XK@117743|Flavobacteriia,2PHF0@252356|Maribacter 976|Bacteroidetes L Domain of unknown function (DUF3127) - - - - - - - - - - - - DUF3127 k59_21763_1 1121271.AUCM01000017_gene474 3.48e-41 144.0 28HHC@1|root,2Z7T2@2|Bacteria,1PZ57@1224|Proteobacteria,2U3R2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S AAA domain - - - - - - - - - - - - AAA_24 k59_117216_2 1325372.N0DPG8_9CAUD 2.32e-22 97.1 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QJZQ@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_349697_1 1207075.PputUW4_02631 4.64e-06 55.8 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins psmE - - - - - - - - - - - Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C k59_349697_2 582899.Hden_1583 1.14e-09 64.7 28MJ5@1|root,2ZAVR@2|Bacteria,1R5CR@1224|Proteobacteria,2UAIJ@28211|Alphaproteobacteria,3N8IV@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Phage_stabilise k59_131130_2 232237.Q7Y5K0_9CAUD 4.57e-43 147.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_215272_3 1504822.CCNO01000015_gene594 8.32e-119 371.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_215272_4 1120971.AUCA01000053_gene371 5.94e-13 67.8 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_252783_1 1150474.JQJI01000006_gene829 1.64e-62 203.0 COG3723@1|root,COG3723@2|Bacteria,2GDKR@200918|Thermotogae 200918|Thermotogae L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_24019_1 1486472.A0A068F3J9_9CAUD 8.16e-87 265.0 4QBNM@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_9880_1 1385658.U5KNR1_9VIRU 1.35e-61 201.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_332976_1 1038860.AXAP01000067_gene8427 4.39e-23 102.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_400455_1 455632.SGR_3347 3.27e-46 159.0 COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria,41CRY@629295|Streptomyces griseus group 201174|Actinobacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_385322_2 367737.Abu_1347 5.87e-21 96.3 29X4D@1|root,30IT8@2|Bacteria,1Q30S@1224|Proteobacteria,42WJT@68525|delta/epsilon subdivisions,2YQ6Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4373) - - - - - - - - - - - - DUF4373 k59_385322_6 1408428.JNJP01000005_gene5 4.05e-16 83.2 2C9JF@1|root,32RPD@2|Bacteria,1N8CG@1224|Proteobacteria,42REW@68525|delta/epsilon subdivisions,2WNQ1@28221|Deltaproteobacteria,2MB30@213115|Desulfovibrionales 28221|Deltaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_237243_1 566461.SSFG_00313 4.28e-06 54.3 COG3409@1|root,COG3409@2|Bacteria,2HB3I@201174|Actinobacteria 201174|Actinobacteria M N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_37941_1 391038.Bphy_1871 4.07e-18 84.7 COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,2VX4R@28216|Betaproteobacteria,1K9WU@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage protein GP46 - - - - - - - - - - - - GP46 k59_37941_2 266265.Bxe_A3047 4.83e-47 166.0 COG3299@1|root,COG3299@2|Bacteria,1PYEJ@1224|Proteobacteria,2VRSP@28216|Betaproteobacteria,1K3BR@119060|Burkholderiaceae 28216|Betaproteobacteria S Baseplate J family protein - - - - - - - - - - - - Baseplate_J k59_134695_1 1096546.WYO_0164 1.28e-35 139.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria 1224|Proteobacteria L COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_335303_1 563192.HMPREF0179_02963 4.65e-09 63.9 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - ko:K03529 - - - - ko00000,ko03036 - - - PhageMin_Tail,Tape_meas_lam_C k59_255299_2 114615.BRADO0464 2.37e-19 83.6 2DS1T@1|root,33E5J@2|Bacteria,1NMAR@1224|Proteobacteria,2UJW9@28211|Alphaproteobacteria,3K5DA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_66653_2 1122614.JHZF01000011_gene1718 2.67e-13 68.9 2C7JB@1|root,2ZXVG@2|Bacteria,1P7GB@1224|Proteobacteria,2UYPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_12830_3 691965.D4P7B9_9CAUD 3.31e-31 114.0 4QFDH@10239|Viruses,4QWV5@35237|dsDNA viruses no RNA stage,4QPB8@28883|Caudovirales,4QKNN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_12830_4 691965.D4P7C0_9CAUD 3.81e-58 183.0 4QDUR@10239|Viruses,4QVMY@35237|dsDNA viruses no RNA stage,4QU8R@28883|Caudovirales,4QKNQ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_12830_5 691965.D4P7C3_9CAUD 1.58e-34 122.0 4QDCX@10239|Viruses,4R0GS@35237|dsDNA viruses no RNA stage,4QS3P@28883|Caudovirales,4QKU8@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_107782_2 877418.ATWV01000001_gene1469 1.87e-09 65.9 COG1861@1|root,COG2227@1|root,COG1861@2|Bacteria,COG2227@2|Bacteria,2J58C@203691|Spirochaetes 203691|Spirochaetes M spore coat polysaccharide biosynthesis protein spsF - - ko:K07257 - - - - ko00000 - - - CTP_transf_3,Methyltransf_23 k59_67134_1 1109445.AGSX01000199_gene2946 1.92e-21 98.6 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria,1Z45I@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_430012_5 266762.HQ36_02140 5.07e-28 122.0 COG3941@1|root,COG3941@2|Bacteria,4NPQ5@976|Bacteroidetes,2FRTG@200643|Bacteroidia 976|Bacteroidetes S tape measure - - - - - - - - - - - - - k59_188173_2 1408415.JHXL01000003_gene1140 2.26e-38 148.0 COG1061@1|root,COG1061@2|Bacteria,3WUEB@544448|Tenericutes 544448|Tenericutes L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,ResIII k59_376152_1 428125.CLOLEP_01417 4.93e-31 118.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,3WMXK@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_41283_4 1280954.HPO_01385 1.86e-07 58.2 COG0500@1|root,COG0500@2|Bacteria,1RIQB@1224|Proteobacteria,2U356@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_23 k59_41283_7 272943.RSP_1626 2.93e-31 123.0 COG3409@1|root,COG3409@2|Bacteria,1RAFU@1224|Proteobacteria,2U9U7@28211|Alphaproteobacteria 28211|Alphaproteobacteria M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - PG_binding_1,Peptidase_M15_4 k59_122076_1 1042156.CXIVA_17100 1.38e-11 62.4 COG0110@1|root,COG0110@2|Bacteria,1TPKX@1239|Firmicutes,249X2@186801|Clostridia,36DHA@31979|Clostridiaceae 186801|Clostridia S Acetyltransferase (Isoleucine patch superfamily) - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 k59_122076_2 279010.BL03050 0.000179 47.0 COG2227@1|root,COG2227@2|Bacteria,1VFEM@1239|Firmicutes,4HQXU@91061|Bacilli 91061|Bacilli H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_135550_1 1385658.U5KNR1_9VIRU 6.81e-74 236.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_135550_3 105154.Q9MBU6_9VIRU 4.45e-220 626.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_135550_4 105154.Q9MBU3_9VIRU 1.7e-15 79.7 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_135550_5 105154.Q9MBU2_9VIRU 6.24e-26 102.0 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_14099_1 78398.KS43_02210 4.45e-25 108.0 COG5297@1|root,COG5297@2|Bacteria,1R6PF@1224|Proteobacteria,1RZMP@1236|Gammaproteobacteria,1MRD8@122277|Pectobacterium 1236|Gammaproteobacteria G Pectate lyase hrpW - - - - - - - - - - - CBM_6,Pectate_lyase k59_283874_4 555779.Dthio_PD0010 3.89e-16 87.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,42NAN@68525|delta/epsilon subdivisions,2WKXF@28221|Deltaproteobacteria,2MAJC@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_338005_1 11082.PRO_0000037753 9.93e-130 394.0 4QBXT@10239|Viruses,4R138@439488|ssRNA viruses,4R0R1@35278|ssRNA positive-strand viruses no DNA stage 10239|Viruses K ATP-dependent helicase activity - GO:0000122,GO:0001172,GO:0001510,GO:0001558,GO:0001817,GO:0001818,GO:0001932,GO:0001933,GO:0001934,GO:0001959,GO:0001960,GO:0001961,GO:0002039,GO:0002673,GO:0002674,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002791,GO:0002792,GO:0002831,GO:0002832,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0003824,GO:0003968,GO:0004175,GO:0004252,GO:0004483,GO:0005102,GO:0005124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005793,GO:0006139,GO:0006355,GO:0006357,GO:0006396,GO:0006417,GO:0006508,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0007155,GO:0007159,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008174,GO:0008233,GO:0008236,GO:0008270,GO:0008284,GO:0008285,GO:0008757,GO:0009058,GO:0009059,GO:0009451,GO:0009452,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010692,GO:0010694,GO:0010803,GO:0010804,GO:0010821,GO:0010823,GO:0010921,GO:0010922,GO:0010941,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016070,GO:0016071,GO:0016192,GO:0016462,GO:0016556,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017016,GO:0017111,GO:0017137,GO:0017151,GO:0017171,GO:0018130,GO:0018995,GO:0019048,GO:0019049,GO:0019050,GO:0019054,GO:0019056,GO:0019058,GO:0019065,GO:0019068,GO:0019080,GO:0019082,GO:0019215,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019899,GO:0019900,GO:0019902,GO:0019903,GO:0020012,GO:0022610,GO:0023051,GO:0023056,GO:0023057,GO:0030162,GO:0030234,GO:0030260,GO:0030307,GO:0030430,GO:0030682,GO:0030683,GO:0030888,GO:0030889,GO:0031072,GO:0031090,GO:0031267,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031330,GO:0031347,GO:0031348,GO:0031369,GO:0031399,GO:0031400,GO:0031401,GO:0031952,GO:0031953,GO:0032069,GO:0032074,GO:0032101,GO:0032102,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032465,GO:0032467,GO:0032675,GO:0032715,GO:0032774,GO:0032780,GO:0032879,GO:0032880,GO:0032944,GO:0032945,GO:0032991,GO:0032993,GO:0033036,GO:0033043,GO:0033116,GO:0033592,GO:0033643,GO:0033644,GO:0033645,GO:0033646,GO:0033647,GO:0033648,GO:0033650,GO:0033655,GO:0033662,GO:0033663,GO:0033668,GO:0033673,GO:0034062,GO:0034121,GO:0034122,GO:0034135,GO:0034136,GO:0034143,GO:0034144,GO:0034155,GO:0034156,GO:0034163,GO:0034164,GO:0034248,GO:0034250,GO:0034641,GO:0034654,GO:0035303,GO:0035306,GO:0035325,GO:0035663,GO:0035821,GO:0036260,GO:0036265,GO:0039502,GO:0039503,GO:0039506,GO:0039507,GO:0039513,GO:0039516,GO:0039526,GO:0039527,GO:0039547,GO:0039560,GO:0039580,GO:0039584,GO:0039612,GO:0039613,GO:0039644,GO:0039653,GO:0039656,GO:0039657,GO:0039713,GO:0039714,GO:0040008,GO:0042000,GO:0042025,GO:0042127,GO:0042287,GO:0042288,GO:0042325,GO:0042326,GO:0042327,GO:0042509,GO:0042532,GO:0042802,GO:0042886,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043086,GO:0043122,GO:0043123,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043414,GO:0043462,GO:0043487,GO:0043489,GO:0043549,GO:0043656,GO:0043657,GO:0043900,GO:0043901,GO:0043902,GO:0043903,GO:0044003,GO:0044053,GO:0044068,GO:0044092,GO:0044093,GO:0044164,GO:0044165,GO:0044167,GO:0044177,GO:0044186,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044220,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044279,GO:0044359,GO:0044362,GO:0044403,GO:0044409,GO:0044413,GO:0044414,GO:0044415,GO:0044417,GO:0044419,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0044531,GO:0044532,GO:0044766,GO:0044833,GO:0044877,GO:0045069,GO:0045070,GO:0045088,GO:0045184,GO:0045727,GO:0045787,GO:0045824,GO:0045862,GO:0045892,GO:0045927,GO:0045934,GO:0045936,GO:0045937,GO:0046425,GO:0046426,GO:0046483,GO:0046718,GO:0046755,GO:0046762,GO:0046774,GO:0046794,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0048583,GO:0048584,GO:0048585,GO:0050670,GO:0050672,GO:0050687,GO:0050688,GO:0050689,GO:0050690,GO:0050691,GO:0050708,GO:0050709,GO:0050727,GO:0050728,GO:0050730,GO:0050732,GO:0050776,GO:0050777,GO:0050789,GO:0050790,GO:0050792,GO:0050794,GO:0050864,GO:0050865,GO:0050866,GO:0050869,GO:0050896,GO:0051020,GO:0051046,GO:0051047,GO:0051048,GO:0051049,GO:0051050,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051253,GO:0051302,GO:0051336,GO:0051338,GO:0051345,GO:0051346,GO:0051348,GO:0051701,GO:0051704,GO:0051707,GO:0051726,GO:0051781,GO:0051805,GO:0051806,GO:0051807,GO:0051808,GO:0051817,GO:0051828,GO:0051832,GO:0051833,GO:0051834,GO:0051836,GO:0052026,GO:0052027,GO:0052029,GO:0052031,GO:0052037,GO:0052038,GO:0052040,GO:0052041,GO:0052053,GO:0052055,GO:0052056,GO:0052148,GO:0052150,GO:0052167,GO:0052170,GO:0052173,GO:0052199,GO:0052200,GO:0052203,GO:0052204,GO:0052205,GO:0052230,GO:0052248,GO:0052250,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052312,GO:0052433,GO:0052490,GO:0052493,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060147,GO:0060149,GO:0060255,GO:0060338,GO:0060339,GO:0060341,GO:0060548,GO:0060589,GO:0060590,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0060759,GO:0060760,GO:0060761,GO:0060966,GO:0060967,GO:0060968,GO:0060969,GO:0065007,GO:0065008,GO:0065009,GO:0070011,GO:0070103,GO:0070104,GO:0070201,GO:0070486,GO:0070663,GO:0070664,GO:0071593,GO:0071702,GO:0071704,GO:0071705,GO:0072583,GO:0075109,GO:0075111,GO:0075112,GO:0075114,GO:0075136,GO:0075344,GO:0075509,GO:0075512,GO:0075528,GO:0080009,GO:0080090,GO:0080134,GO:0080135,GO:0090068,GO:0090087,GO:0090199,GO:0090201,GO:0090304,GO:0097159,GO:0097617,GO:0097659,GO:0097677,GO:0097747,GO:0098588,GO:0098609,GO:0098657,GO:0098772,GO:0106005,GO:0140096,GO:0140098,GO:1900101,GO:1900102,GO:1900117,GO:1900118,GO:1900368,GO:1900369,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1902369,GO:1902531,GO:1902532,GO:1902533,GO:1902579,GO:1902679,GO:1903265,GO:1903506,GO:1903507,GO:1903530,GO:1903531,GO:1903573,GO:1903719,GO:1903721,GO:1903900,GO:1903902,GO:1904892,GO:1904893,GO:1904950,GO:1905897,GO:1990214,GO:1990216,GO:1990219,GO:1990254,GO:1990814,GO:1990904,GO:2000112,GO:2000113,GO:2001141,GO:2001233,GO:2001234 - - - - - - - - - - - k59_351516_1 145579.H_BPPHM 9.74e-19 85.9 4QCA6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_351516_2 145579.CAPSD_BPPHM 7.33e-236 665.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_351516_3 145579.REP_BPPHM 2.87e-118 350.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_162552_2 742740.HMPREF9474_02263 5.18e-37 129.0 2ARVA@1|root,31H70@2|Bacteria,1V7JT@1239|Firmicutes,24JPE@186801|Clostridia,222RD@1506553|Lachnoclostridium 186801|Clostridia S Bacteriophage HK97-gp10, putative tail-component - - - - - - - - - - - - HK97-gp10_like k59_162552_3 1403948.Q618_VCMC00001G0116 9.78e-25 120.0 COG3941@1|root,COG5412@1|root,COG3941@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,4D5NS@85005|Actinomycetales 201174|Actinobacteria D tape measure - - - - - - - - - - - - PhageMin_Tail k59_243731_1 1123276.KB893251_gene3617 2.83e-06 55.1 COG1874@1|root,COG2755@1|root,COG3386@1|root,COG1874@2|Bacteria,COG2755@2|Bacteria,COG3386@2|Bacteria,4PPRK@976|Bacteroidetes,47TYG@768503|Cytophagia 976|Bacteroidetes G Dystroglycan-type cadherin-like domains. - - - - - - - - - - - - - k59_311503_1 595460.RRSWK_03363 4.04e-221 621.0 COG3306@1|root,COG3551@1|root,COG3306@2|Bacteria,COG3551@2|Bacteria,2J3XB@203682|Planctomycetes 203682|Planctomycetes M glycosyltransferase involved in LPS biosynthesis - - - - - - - - - - - - Glyco_transf_25 k59_311503_2 1026882.MAMP_03044 3.15e-11 68.2 COG1196@1|root,COG1196@2|Bacteria,1R4QE@1224|Proteobacteria,1S28W@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_311503_3 1236501.BAJU01000041_gene2731 3.24e-18 95.5 COG1216@1|root,COG5610@1|root,COG1216@2|Bacteria,COG5610@2|Bacteria,1MX5Z@1224|Proteobacteria,2U0IP@28211|Alphaproteobacteria,2JR4E@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_311503_4 1541065.JRFE01000024_gene786 5.84e-31 122.0 COG3774@1|root,COG3774@2|Bacteria,1GFKE@1117|Cyanobacteria 1117|Cyanobacteria M Capsular polysaccharide synthesis protein - - - - - - - - - - - - Caps_synth k59_177311_1 1692244.A0A0K1RLR5_9CIRC 1.77e-97 294.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_353275_1 880073.Calab_1754 1.83e-10 73.9 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.4,3.4.21.66 ko:K01179,ko:K08651 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko03110 - GH5,GH9 - Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3 k59_353275_4 7719.XP_002130552.1 2.5e-52 179.0 COG0692@1|root,KOG2994@2759|Eukaryota,38HPB@33154|Opisthokonta,3BGKX@33208|Metazoa,3CW1J@33213|Bilateria,485JP@7711|Chordata 33208|Metazoa L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine UNG GO:0000018,GO:0002200,GO:0002376,GO:0002377,GO:0002440,GO:0002520,GO:0002562,GO:0002566,GO:0002637,GO:0002639,GO:0002682,GO:0002684,GO:0002694,GO:0002696,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002703,GO:0002705,GO:0002706,GO:0002708,GO:0002712,GO:0002714,GO:0002819,GO:0002821,GO:0002822,GO:0002824,GO:0002889,GO:0002891,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0004844,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006139,GO:0006220,GO:0006244,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006310,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009893,GO:0009987,GO:0010604,GO:0010941,GO:0016444,GO:0016445,GO:0016446,GO:0016447,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019104,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042981,GO:0043021,GO:0043024,GO:0043066,GO:0043067,GO:0043069,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045008,GO:0045191,GO:0045830,GO:0045911,GO:0045935,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050864,GO:0050865,GO:0050867,GO:0050871,GO:0050896,GO:0051052,GO:0051054,GO:0051094,GO:0051171,GO:0051173,GO:0051239,GO:0051240,GO:0051249,GO:0051251,GO:0051716,GO:0055086,GO:0060255,GO:0060548,GO:0065007,GO:0070013,GO:0071704,GO:0072527,GO:0072529,GO:0080090,GO:0090304,GO:0097159,GO:0097506,GO:0097510,GO:0140097,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:2000026 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_353275_6 880073.Calab_1527 1.18e-22 94.7 COG3023@1|root,COG3023@2|Bacteria,2NRUX@2323|unclassified Bacteria 2|Bacteria V SPTR N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD - - - - - - - - - - - - Amidase_2,LysM,PG_binding_1 k59_29335_1 365046.Rta_12630 5.04e-21 100.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs-related protein - - - - - - - - - - - - RHS,RHS_repeat k59_420054_1 1074889.MADAR_456 2.7e-09 65.1 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,1HWS1@117743|Flavobacteriia,3IVBY@39782|Blattabacteriaceae 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_204859_1 56107.Cylst_5656 0.000885 52.8 COG0326@1|root,COG0326@2|Bacteria,1G0H8@1117|Cyanobacteria,1HJBG@1161|Nostocales 1117|Cyanobacteria O PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_177319_1 1692242.A0A0K1RL37_9CIRC 1.1e-46 161.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_298823_2 1297534.CAUJ01000005_gene180 0.000887 46.6 COG3740@1|root,COG3740@2|Bacteria 2|Bacteria OU Phage prohead protease, HK97 family - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_271607_3 1385658.U5KPZ6_9VIRU 6.85e-111 339.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_29524_1 359.CN09_09375 7.79e-28 111.0 COG0863@1|root,COG0863@2|Bacteria,1PCS4@1224|Proteobacteria,2VDM8@28211|Alphaproteobacteria,4BIRX@82115|Rhizobiaceae 28211|Alphaproteobacteria H DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_29524_2 1504822.CCNO01000015_gene594 9.48e-101 325.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_29524_5 1340827.S5YLC4_9CAUD 1.99e-21 92.4 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_353504_1 1121926.AXWO01000004_gene1187 3.75e-20 90.1 2B815@1|root,3218Y@2|Bacteria,2H57E@201174|Actinobacteria 201174|Actinobacteria S Rad52/22 family double-strand break repair protein - - - - - - - - - - - - Rad52_Rad22 k59_177505_1 1123288.SOV_2c10440 9.78e-113 341.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,4H2V4@909932|Negativicutes 909932|Negativicutes KL DEAD-like helicases superfamily - - - - - - - - - - - - N6_N4_Mtase k59_258666_2 760568.Desku_1126 1.34e-27 110.0 COG1475@1|root,COG4725@1|root,COG1475@2|Bacteria,COG4725@2|Bacteria,1TT7N@1239|Firmicutes,24D10@186801|Clostridia 186801|Clostridia L ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_394713_2 945712.CULC22_01188 1.42e-36 142.0 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria,22MKV@1653|Corynebacteriaceae 201174|Actinobacteria L DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_139936_1 948071.S4S2D9_9CAUD 1.6e-34 132.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_111461_1 44056.XP_009041542.1 3.33e-23 94.4 2E552@1|root,2SBZD@2759|Eukaryota 44056.XP_009041542.1|- S HNH endonuclease - - - - - - - - - - - - - k59_140184_6 1262449.CP6013_1798 0.000186 52.8 COG0542@1|root,COG0542@2|Bacteria,1UJ1Z@1239|Firmicutes,24AIQ@186801|Clostridia,36GMD@31979|Clostridiaceae 186801|Clostridia O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_179508_1 102125.Xen7305DRAFT_00043160 4.47e-06 56.6 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1G0R8@1117|Cyanobacteria,3VJAP@52604|Pleurocapsales 1117|Cyanobacteria L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_286841_1 937777.Deipe_0483 5.41e-73 232.0 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_179509_1 1408473.JHXO01000009_gene3473 2.67e-05 50.4 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,2FMUU@200643|Bacteroidia 976|Bacteroidetes M NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase,GDP_Man_Dehyd k59_179509_2 1304866.K413DRAFT_4653 7.84e-12 62.4 COG0742@1|root,COG0742@2|Bacteria,1UN8R@1239|Firmicutes,250IW@186801|Clostridia,36RQ5@31979|Clostridiaceae 186801|Clostridia L ribosomal rna small subunit methyltransferase - - - - - - - - - - - - - k59_342458_1 1122931.AUAE01000034_gene2778 1.66e-17 85.9 COG0467@1|root,COG0467@2|Bacteria,4P31Y@976|Bacteroidetes,2FSV1@200643|Bacteroidia 976|Bacteroidetes T AAA domain - - - - - - - - - - - - AAA_25 k59_44264_1 292459.STH659 4.92e-19 94.7 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia 186801|Clostridia L DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_260531_1 365044.Pnap_0613 2.94e-56 198.0 COG0675@1|root,COG0675@2|Bacteria,1MUU0@1224|Proteobacteria,2VJG9@28216|Betaproteobacteria,4AFBK@80864|Comamonadaceae 28216|Betaproteobacteria L transposase, IS891 IS1136 IS1341 family - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_17454_2 813.O172_04705 5.57e-05 48.5 COG0465@1|root,COG0465@2|Bacteria,2JFFV@204428|Chlamydiae 204428|Chlamydiae D Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 k59_3828_1 1121405.dsmv_3311 1.75e-10 61.6 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MHQJ@213118|Desulfobacterales 28221|Deltaproteobacteria OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_3828_2 215803.DB30_1752 7.28e-45 156.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2YUJA@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_124761_2 1123269.NX02_04425 8.54e-18 83.6 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria,2K2MZ@204457|Sphingomonadales 204457|Sphingomonadales S Phage portal protein - - - - - - - - - - - - Phage_portal k59_165700_1 977880.RALTA_B0417 9.46e-13 74.3 COG5164@1|root,COG5164@2|Bacteria,1N2ZN@1224|Proteobacteria,2W0KB@28216|Betaproteobacteria,1KCZE@119060|Burkholderiaceae 28216|Betaproteobacteria K regulation of DNA-templated transcription, elongation - - - - - - - - - - - - - k59_394874_1 1556290.A0A0A0RQH0_9CAUD 1.37e-39 171.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_315952_2 1556290.A0A0A0RSX5_9CAUD 2.53e-55 182.0 4QCAU@10239|Viruses,4QPJ6@28883|Caudovirales,4QKZJ@10699|Siphoviridae 10699|Siphoviridae S Pfam:GP88 - - - - - - - - - - - - - k59_355670_1 1465751.W8QRA8_9VIRU 1.34e-57 184.0 4QHPK@10239|Viruses,4QXKH@35237|dsDNA viruses no RNA stage 10239|Viruses S Fasciclin domain - - - - - - - - - - - - - k59_355670_2 1465751.W8R9M2_9VIRU 3.29e-281 776.0 4QGXM@10239|Viruses,4QY0N@35237|dsDNA viruses no RNA stage 10239|Viruses S Papain family cysteine protease - - - - - - - - - - - - - k59_344839_2 357276.EL88_11455 3.85e-33 128.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria,4NHHF@976|Bacteroidetes,2FRI5@200643|Bacteroidia,4ATW7@815|Bacteroidaceae 976|Bacteroidetes KL DNA methylase - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_344846_1 1144305.PMI02_03196 3.53e-08 59.7 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,2K2QM@204457|Sphingomonadales 204457|Sphingomonadales S Phage portal protein - - - - - - - - - - - - Phage_portal k59_33703_1 443152.MDG893_20559 7.11e-87 279.0 COG2911@1|root,COG2911@2|Bacteria,1QU6S@1224|Proteobacteria,1S7WY@1236|Gammaproteobacteria 1236|Gammaproteobacteria D tail tape measure protein - - - - - - - - - - - - SLT,Tape_meas_lam_C k59_288734_2 525904.Tter_0501 0.00013 50.4 COG1475@1|root,COG1475@2|Bacteria,2NP7S@2323|unclassified Bacteria 2|Bacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_288734_3 1161931.J7FAE2_9CAUD 5.6e-26 108.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_5730_5 105154.Q9MBU3_9VIRU 3.61e-14 75.9 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_100931_4 1509405.GV67_04245 1.77e-24 98.2 COG3023@1|root,COG3023@2|Bacteria,1N032@1224|Proteobacteria,2U6P9@28211|Alphaproteobacteria,4BHDN@82115|Rhizobiaceae 28211|Alphaproteobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_210020_1 931276.Cspa_c07890 0.000134 51.2 2DZCS@1|root,32V7E@2|Bacteria,1UNBM@1239|Firmicutes,25H06@186801|Clostridia,36V6K@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_75892_1 438753.AZC_0840 1.66e-38 147.0 COG3170@1|root,COG3170@2|Bacteria,1R69E@1224|Proteobacteria,2U3B9@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Phage P22-like portal protein - - - - - - - - - - - - - k59_33916_1 1283300.ATXB01000001_gene1779 8.61e-63 203.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1XDR5@135618|Methylococcales 135618|Methylococcales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_275103_1 1035308.AQYY01000002_gene709 3.3e-23 101.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,261AB@186807|Peptococcaceae 186801|Clostridia E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_358770_2 1304275.C41B8_05583 1.88e-12 68.2 COG1974@1|root,COG1974@2|Bacteria,1RHIM@1224|Proteobacteria,1SD51@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT repressor protein - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_90330_1 927677.ALVU02000006_gene443 4.46e-32 120.0 COG1196@1|root,COG1196@2|Bacteria,1GEKG@1117|Cyanobacteria 1117|Cyanobacteria D DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - Dam k59_21851_1 1611039.A0A0C5C3Z3_9CIRC 1.77e-70 225.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_250793_1 1123035.ARLA01000028_gene2124 6.48e-06 53.5 COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,1HXGK@117743|Flavobacteriia,4C3BS@83612|Psychroflexus 976|Bacteroidetes H Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_23 k59_62060_1 1465751.W8QE76_9VIRU 3.69e-15 73.2 4QAW0@10239|Viruses,4QXED@35237|dsDNA viruses no RNA stage 10239|Viruses S Deoxynucleoside kinase - - - - - - - - - - - - - k59_62060_2 1465751.W8QN10_9VIRU 3.77e-29 110.0 4QBCE@10239|Viruses,4QYNU@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_62060_4 1465751.W8QMW4_9VIRU 2.77e-36 136.0 4QFR9@10239|Viruses,4QY44@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_62060_5 1465751.W8QMW9_9VIRU 4.31e-86 259.0 4QFN9@10239|Viruses,4QYW9@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_62060_6 345201.VF205_IIV3 4.22e-51 187.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA ligase (NAD+) activity - - - - - - - - - - - - - k59_115633_1 1385658.U5KPZ6_9VIRU 2.03e-72 236.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_90659_1 1141106.CAIB01000133_gene1117 6.28e-20 87.4 2EVUX@1|root,33P8N@2|Bacteria,1VUVM@1239|Firmicutes 1239|Firmicutes L HNH endonuclease - - - - - - - - - - - - HNH_3 k59_413321_3 471223.GWCH70_3133 6.5e-09 61.2 COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,4ISYS@91061|Bacilli,1WF59@129337|Geobacillus 91061|Bacilli M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,PG_binding_1 k59_8151_1 545695.TREAZ_1034 5.07e-09 54.7 2A7RX@1|root,30WQU@2|Bacteria,2JAQ9@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_212800_2 1210884.HG799464_gene11320 4.75e-64 209.0 COG4725@1|root,COG4725@2|Bacteria,2J40U@203682|Planctomycetes 203682|Planctomycetes KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 k59_184897_1 1211115.ALIQ01000188_gene622 7.62e-27 119.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,2UNT9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_184897_2 1349822.NSB1T_14140 1.01e-10 65.1 COG1088@1|root,COG1088@2|Bacteria,4NE9V@976|Bacteroidetes,2FMUH@200643|Bacteroidia,22W2K@171551|Porphyromonadaceae 976|Bacteroidetes M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_307330_1 1589746.A0A0B5A4C2_9CAUD 5.65e-27 114.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_37807_2 2003327.CAPSD_BPCHP 1.35e-30 120.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_23924_7 1121912.AUHD01000006_gene1278 2.33e-06 58.9 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,4NECV@976|Bacteroidetes,1HXAD@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF3427) - - - - - - - - - - - - DUF3427,Helicase_C,PLDc_2,ResIII k59_293616_1 102129.Lepto7375DRAFT_5153 3.75e-35 134.0 COG3108@1|root,COG3772@1|root,COG3108@2|Bacteria,COG3772@2|Bacteria,1G8P3@1117|Cyanobacteria,1HG8C@1150|Oscillatoriales 1117|Cyanobacteria S Peptidase M15 - - - - - - - - - - - - Jacalin,Peptidase_M15_3,Phage_lysozyme k59_92330_9 1144275.COCOR_02360 4.11e-08 53.9 COG0742@1|root,COG0863@1|root,COG0742@2|Bacteria,COG0863@2|Bacteria,1NXST@1224|Proteobacteria,43BMK@68525|delta/epsilon subdivisions 1224|Proteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_278755_1 457398.HMPREF0326_02660 9.17e-33 130.0 COG4227@1|root,COG4643@1|root,COG4227@2|Bacteria,COG4643@2|Bacteria,1MU8I@1224|Proteobacteria,42N43@68525|delta/epsilon subdivisions,2WM7N@28221|Deltaproteobacteria,2M823@213115|Desulfovibrionales 28221|Deltaproteobacteria L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738,Toprim_3 k59_415008_2 936152.F5A3E4_9CAUD 2.83e-30 114.0 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QKM5@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding - - - - - - - - - - - - - k59_415008_3 749222.Nitsa_1194 5.28e-42 142.0 2AJ1X@1|root,319K5@2|Bacteria,1RK0X@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2829) - - - - - - - - - - - - DUF2829 k59_237170_2 56107.Cylst_1960 8.32e-34 135.0 COG5655@1|root,COG5655@2|Bacteria,1GE7K@1117|Cyanobacteria,1HT1G@1161|Nostocales 1117|Cyanobacteria L Replication protein - - - - - - - - - - - - Rep_1 k59_307662_2 1221522.B723_16595 2.69e-17 75.9 COG1328@1|root,COG1328@2|Bacteria,1QSB7@1224|Proteobacteria,1RVQF@1236|Gammaproteobacteria,1YU95@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Anaerobic ribonucleoside-triphosphate reductase - - - - - - - - - - - - NRDD k59_415381_2 911008.GLAD_01282 4.47e-14 75.5 28H9R@1|root,2Z7MD@2|Bacteria,1MVTR@1224|Proteobacteria,1RMPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Psort location Cytoplasmic, score 8.96 yfjQ - - - - - - - - - - - DUF932 k59_201566_1 1443122.Z958_05730 3.53e-74 233.0 COG3723@1|root,COG3723@2|Bacteria,1UNDF@1239|Firmicutes,24ECD@186801|Clostridia,36HN4@31979|Clostridiaceae 186801|Clostridia L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_40149_1 1244869.H261_10537 2.7e-65 213.0 COG0175@1|root,COG0175@2|Bacteria,1PZ96@1224|Proteobacteria 1224|Proteobacteria EH 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes - - - - - - - - - - - - PAPS_reduct k59_134001_1 298653.Franean1_2577 1.88e-47 167.0 28HEE@1|root,2Z7QU@2|Bacteria,2I1I5@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_26207_2 1123503.KB908060_gene135 1.02e-48 171.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2KFUP@204458|Caulobacterales 204458|Caulobacterales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_428941_1 278963.ATWD01000001_gene2981 0.00039 48.1 COG1032@1|root,COG1032@2|Bacteria,3Y2QU@57723|Acidobacteria,2JI2U@204432|Acidobacteriia 204432|Acidobacteriia C TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ - - - - - - - - - - - - B12-binding,Radical_SAM k59_296685_1 484770.UFO1_1697 8.83e-52 182.0 COG5511@1|root,COG5511@2|Bacteria,1TQ8B@1239|Firmicutes,4H6G2@909932|Negativicutes 909932|Negativicutes S Phage portal protein - - - - - - - - - - - - Phage_portal_2 k59_296685_2 1122201.AUAZ01000004_gene3425 1.14e-52 179.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,1RZZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU peptidase JD73_18850 - - ko:K21511 - - - - ko00000,ko01000 - - - Peptidase_S49 k59_402390_2 411461.DORFOR_02694 2.11e-08 55.8 COG1476@1|root,COG1476@2|Bacteria,1W0CP@1239|Firmicutes,253XZ@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_402390_3 548479.HMPREF0573_11262 2.55e-32 120.0 2E2AR@1|root,32XG5@2|Bacteria 2|Bacteria S PFAM Pathogenesis-related transcriptional factor and ERF - - - - - - - - - - - - AP2,HNH_3 k59_187050_1 665942.HMPREF1022_00109 1.29e-05 48.1 2CWYZ@1|root,32T0P@2|Bacteria,1MZEM@1224|Proteobacteria,4337C@68525|delta/epsilon subdivisions,2WXPD@28221|Deltaproteobacteria,2MCUC@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_26208_1 468059.AUHA01000002_gene1007 7.88e-60 219.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NIIR@976|Bacteroidetes,1IPF7@117747|Sphingobacteriia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_225393_4 691965.D4P7D3_9CAUD 7e-163 472.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_225393_5 428125.CLOLEP_01412 1.53e-62 215.0 28JK5@1|root,2Z9D1@2|Bacteria,1UJZJ@1239|Firmicutes,24D64@186801|Clostridia,3WMZ3@541000|Ruminococcaceae 186801|Clostridia S Caudovirus prohead serine protease - - - - - - - - - - - - Peptidase_S78 k59_386846_1 643562.Daes_0095 4.61e-07 54.7 COG4122@1|root,COG4122@2|Bacteria,1N2AR@1224|Proteobacteria,439ZI@68525|delta/epsilon subdivisions,2X2GU@28221|Deltaproteobacteria,2MDMY@213115|Desulfovibrionales 28221|Deltaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_375401_1 1114179.I2FLT8_9CAUD 3.72e-36 138.0 4QAUF@10239|Viruses,4QWIQ@35237|dsDNA viruses no RNA stage,4QUFS@28883|Caudovirales,4QNVK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_375401_2 697281.Mahau_0077 2.84e-39 148.0 COG0507@1|root,COG0507@2|Bacteria,1TQWH@1239|Firmicutes,24A8I@186801|Clostridia,42HVJ@68295|Thermoanaerobacterales 186801|Clostridia L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_187485_1 1120792.JAFV01000001_gene592 3.9e-16 83.6 COG3740@1|root,COG3740@2|Bacteria 2|Bacteria OU Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_310140_1 1320556.AVBP01000012_gene3527 4.08e-12 77.4 COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2U7WD@28211|Alphaproteobacteria,43HH0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria DZ Autotransporter beta-domain - - - - - - - - - - - - Autotransporter,He_PIG k59_175128_1 1692242.A0A0K1RL37_9CIRC 9.81e-13 72.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_417652_3 10685.B6V2J2_BPSP1 4.74e-35 137.0 4QBA2@10239|Viruses,4QV98@35237|dsDNA viruses no RNA stage,4QPPI@28883|Caudovirales,4QIA3@10662|Myoviridae 10662|Myoviridae S Thymidylate synthase - - - - - - - - - - - - - k59_281893_1 1234888.K0A2J2_9VIRU 1.86e-58 199.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_378747_1 1041159.AZUW01000001_gene3269 2.18e-10 61.2 COG4397@1|root,COG4397@2|Bacteria,1MWX8@1224|Proteobacteria,2U0B4@28211|Alphaproteobacteria,4BC6J@82115|Rhizobiaceae 28211|Alphaproteobacteria S Mu-like prophage major head subunit gpT - - - - - - - - - - - - Mu-like_gpT k59_378747_2 1041159.AZUW01000001_gene3268 9.55e-48 157.0 2AD4I@1|root,300N2@2|Bacteria,1PR6C@1224|Proteobacteria,2V3HE@28211|Alphaproteobacteria,4BKMT@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_95262_1 269800.Tfu_2135 1.15e-09 56.2 2E39Y@1|root,32Y9G@2|Bacteria,2GQJA@201174|Actinobacteria,4EKEQ@85012|Streptosporangiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_81853_2 755178.Cyan10605_3491 9.99e-21 103.0 COG0210@1|root,COG0210@2|Bacteria,1GQP4@1117|Cyanobacteria 1117|Cyanobacteria L PFAM UvrD REP helicase - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_81853_12 1227454.C446_15548 5.41e-19 87.0 arCOG06669@1|root,arCOG06669@2157|Archaea,2XV2H@28890|Euryarchaeota,23TAZ@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - k59_175968_1 1210884.HG799466_gene12740 9.12e-28 111.0 2C9JF@1|root,32RPD@2|Bacteria 2|Bacteria S Erf family - - - - - - - - - - - - ERF k59_270600_1 582899.Hden_1166 7.95e-72 223.0 COG0175@1|root,COG0175@2|Bacteria,1R52W@1224|Proteobacteria,2U0Y4@28211|Alphaproteobacteria,3N7GH@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria EH COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes - - - - - - - - - - - - PAPS_reduct k59_365130_1 596152.DesU5LDRAFT_1920 1.04e-05 52.4 2DNNG@1|root,32Y9C@2|Bacteria,1N8A7@1224|Proteobacteria,436N9@68525|delta/epsilon subdivisions,2X19Z@28221|Deltaproteobacteria,2MEK4@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_297554_2 767806.D7PQ37_9CAUD 4.03e-22 94.7 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_149287_1 691965.D4P7D6_9CAUD 9.49e-51 183.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_229975_1 888055.HMPREF9015_01046 1.53e-43 174.0 COG5525@1|root,COG5525@2|Bacteria,378SY@32066|Fusobacteria 32066|Fusobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_229975_3 448385.sce1864 7.93e-23 104.0 COG0615@1|root,COG0615@2|Bacteria,1N9T6@1224|Proteobacteria 1224|Proteobacteria IM Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_82078_1 1236514.BAKL01000024_gene2261 5.56e-57 187.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,2FN5D@200643|Bacteroidia,4AKG4@815|Bacteroidaceae 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_340123_1 1385658.U5KPZ6_9VIRU 5.84e-144 426.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_340123_5 1165094.RINTHH_3920 7.12e-63 207.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_110087_1 1088721.NSU_pLA2074 1.97e-07 51.2 2AKKP@1|root,31BD1@2|Bacteria,1NYYR@1224|Proteobacteria,2UT2T@28211|Alphaproteobacteria,2KAYI@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_353456_5 113395.AXAI01000002_gene5437 1.23e-71 231.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria,3JU4C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_340131_1 281090.Lxx24020 2.2e-14 81.6 COG4626@1|root,COG4626@2|Bacteria,2IB7D@201174|Actinobacteria,4FMQD@85023|Microbacteriaceae 201174|Actinobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_123463_1 699218.HMPREF0889_1600 5.43e-07 55.1 COG0270@1|root,COG0270@2|Bacteria,1UJ1G@1239|Firmicutes 1239|Firmicutes H Adenine-specific methyltransferase EcoRI dcm - - - - - - - - - - - DNA_methylase,EcoRI_methylase k59_164003_3 279238.Saro_2740 5e-15 82.8 29WB4@1|root,30HWN@2|Bacteria,1PDVG@1224|Proteobacteria,2VDTZ@28211|Alphaproteobacteria,2KBWY@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_123661_2 313606.M23134_00227 1.59e-16 82.8 COG0756@1|root,COG0756@2|Bacteria 2|Bacteria F dUTP diphosphatase activity dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_70923_1 172088.AUGA01000017_gene2380 6.68e-48 166.0 COG3206@1|root,COG3206@2|Bacteria,1ND5H@1224|Proteobacteria,2UIQZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - k59_150914_7 545693.BMQ_3141 6.91e-23 101.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1V3MD@1239|Firmicutes,4HHD1@91061|Bacilli,1ZGHS@1386|Bacillus 91061|Bacilli M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,LysM k59_150914_8 1235794.C811_01078 3.05e-14 73.6 COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CUM5@84998|Coriobacteriia 84998|Coriobacteriia L Uracil-DNA glycosylase, family 4 - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_18696_1 679926.Mpet_2297 1.11e-11 68.2 COG0863@1|root,arCOG00115@2157|Archaea,2Y00D@28890|Euryarchaeota 28890|Euryarchaeota L modification methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_32685_1 177437.HRM2_28810 1.79e-31 135.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MHXP@213118|Desulfobacterales 28221|Deltaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_32685_3 1321814.HMPREF9089_00383 1.83e-23 99.8 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,25VB3@186806|Eubacteriaceae 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_233294_1 392500.Swoo_3945 2.17e-11 62.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,1SFR6@1236|Gammaproteobacteria,2Q8IH@267890|Shewanellaceae 1236|Gammaproteobacteria F PFAM CMP dCMP deaminase zinc-binding - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_193563_1 1556290.A0A0A0RL61_9CAUD 4.98e-62 208.0 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_219260_1 61647.LG71_19615 1.27e-11 63.2 COG4570@1|root,COG4570@2|Bacteria,1N92D@1224|Proteobacteria,1S5SJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC rusA - 3.1.22.4 ko:K01160 - - - - ko00000,ko01000,ko03400 - - - RusA k59_317392_2 1121890.AUDO01000004_gene2057 5.48e-40 137.0 2AA3W@1|root,30ZCS@2|Bacteria,4PDJS@976|Bacteroidetes,1IE12@117743|Flavobacteriia,2NZMI@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_74561_1 1211777.BN77_4172 3.58e-53 183.0 2CC8M@1|root,308VJ@2|Bacteria,1R789@1224|Proteobacteria,2U2NB@28211|Alphaproteobacteria,4BHET@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_369151_3 1116375.VEJY3_09835 2.28e-19 85.9 COG2852@1|root,COG2852@2|Bacteria,1N2UX@1224|Proteobacteria,1TIHC@1236|Gammaproteobacteria,1XZ4M@135623|Vibrionales 135623|Vibrionales S Protein conserved in bacteria - - - - - - - - - - - - - k59_125922_7 1291050.JAGE01000001_gene475 1.42e-42 153.0 COG0338@1|root,COG0338@2|Bacteria,1UBIY@1239|Firmicutes,24D2Y@186801|Clostridia 186801|Clostridia L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_249699_1 1500301.JQMF01000006_gene1760 5.1e-50 178.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria,4BIH2@82115|Rhizobiaceae 28211|Alphaproteobacteria L DNA polymerase A domain - - - - - - - - - - - - DNA_pol_A k59_249699_4 1197951.I6R0Z0_9CAUD 2.09e-61 203.0 4QGZN@10239|Viruses,4R0FF@35237|dsDNA viruses no RNA stage,4QTUK@28883|Caudovirales 28883|Caudovirales S nuclease activity - - - - - - - - - - - - - k59_249699_7 1555208.A0A097EW28_9CAUD 1.81e-27 112.0 4QDM7@10239|Viruses,4QPZC@28883|Caudovirales,4QN8I@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_249699_10 3067.XP_002955713.1 5.01e-64 218.0 COG1372@1|root,2QRRC@2759|Eukaryota 2759|Eukaryota L reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Ribonuc_red_lgC k59_144451_2 1297570.MESS4_510150 2.98e-10 63.5 2DP75@1|root,330U8@2|Bacteria,1N8XA@1224|Proteobacteria,2UIHW@28211|Alphaproteobacteria,43QHP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - AP2,HNH_3 k59_182097_4 555079.Toce_1280 1.9e-26 109.0 28JC4@1|root,2Z96S@2|Bacteria,1TS1K@1239|Firmicutes,249Q6@186801|Clostridia 186801|Clostridia S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - P22_CoatProtein k59_382892_1 1618248.A0A0C5IB82_9CIRC 1.49e-24 106.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_382892_2 1788454.A0A190WHE4_9CIRC 2.65e-14 73.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_249705_2 1122138.AQUZ01000134_gene8841 1.93e-43 149.0 COG1475@1|root,COG1475@2|Bacteria,2H5ZI@201174|Actinobacteria 201174|Actinobacteria K ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_263827_1 649747.HMPREF0083_05304 1.21e-13 84.0 COG5280@1|root,COG5280@2|Bacteria,1UHTF@1239|Firmicutes,4IS94@91061|Bacilli,27752@186822|Paenibacillaceae 91061|Bacilli S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_20589_1 1327981.R9ZYI1_9CAUD 1.14e-37 135.0 4QC5Z@10239|Viruses,4QUNP@35237|dsDNA viruses no RNA stage,4QPGX@28883|Caudovirales,4QKMB@10699|Siphoviridae 10699|Siphoviridae S Phage Mu protein F like protein - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_155739_1 113395.AXAI01000008_gene735 2.26e-27 110.0 COG1403@1|root,COG1403@2|Bacteria,1N0FM@1224|Proteobacteria,2TWQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ERF superfamily - - - - - - - - - - - - ERF k59_34693_1 1070319.CAGGBEG34_640002 8.51e-40 142.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2VJ0N@28216|Betaproteobacteria,1K5G3@119060|Burkholderiaceae 28216|Betaproteobacteria OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_34693_2 637910.ROD_25991 2.06e-92 290.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RPUT@1236|Gammaproteobacteria,3WYG3@544|Citrobacter 1236|Gammaproteobacteria S Phage portal protein, lambda family JD73_18735 - - - - - - - - - - - Phage_portal_2 k59_397570_4 1131812.JQMS01000001_gene52 1.71e-12 65.1 2AA6Y@1|root,30ZG0@2|Bacteria,4PDQN@976|Bacteroidetes,1INJM@117743|Flavobacteriia,2NZVB@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_127501_1 1121271.AUCM01000008_gene3222 2.23e-41 145.0 COG0860@1|root,COG0860@2|Bacteria,1N0ME@1224|Proteobacteria,2UEG9@28211|Alphaproteobacteria 28211|Alphaproteobacteria M N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_3 k59_195468_1 63737.Npun_R0864 3.23e-17 87.0 COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1G04D@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - CARDB,Peptidase_S8 k59_319848_1 1589298.A0A0B5H2Y7_9CAUD 1.47e-10 62.8 4QDCQ@10239|Viruses,4QPZZ@28883|Caudovirales,4QM93@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF1768) - - - - - - - - - - - - - k59_7987_1 420324.KI911948_gene9093 1.11e-55 192.0 COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,1JX89@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM peptidase U35 phage prohead HK97 - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_146688_3 1029823.AFIE01000007_gene1892 1.87e-19 85.5 2DYV8@1|root,32V63@2|Bacteria,1QNWV@1224|Proteobacteria,1ST2X@1236|Gammaproteobacteria,3NNP1@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_35916_1 796620.VIBC2010_14674 5.39e-57 187.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XTZ0@135623|Vibrionales 135623|Vibrionales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_35916_2 742766.HMPREF9455_02805 1.33e-42 143.0 COG0720@1|root,COG0720@2|Bacteria,4NQYM@976|Bacteroidetes,2FSMG@200643|Bacteroidia,22YHS@171551|Porphyromonadaceae 976|Bacteroidetes H 6-pyruvoyl tetrahydropterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_35916_3 1116472.MGMO_52c00260 6.05e-14 73.2 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1XDUJ@135618|Methylococcales 135618|Methylococcales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_321418_1 1150626.PHAMO_490017 7.79e-07 56.2 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,2JTE5@204441|Rhodospirillales 204441|Rhodospirillales S Phage portal protein - - - - - - - - - - - - Phage_portal k59_79196_2 1173709.M3VMK9_9CIRC 7.47e-20 94.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_22011_2 1192034.CAP_6900 1.03e-15 77.4 COG2605@1|root,COG2605@2|Bacteria,1QW1A@1224|Proteobacteria,42N0X@68525|delta/epsilon subdivisions,2WJYP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM GHMP kinase - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_90842_2 67356.KL575597_gene7633 6.17e-35 134.0 COG1403@1|root,COG1403@2|Bacteria,2IAYP@201174|Actinobacteria 201174|Actinobacteria L HNH endonuclease - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_196832_1 1469607.KK073769_gene5883 2.95e-10 67.8 COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1GHDU@1117|Cyanobacteria 1117|Cyanobacteria Q PFAM 5'-nucleotidase, C-terminal domain - - - ko:K07004 - - - - ko00000 - - - Calx-beta,Exo_endo_phos,HemolysinCabind,LTD k59_372073_1 1173762.S4TT51_9CAUD 1.81e-43 155.0 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QNDS@10744|Podoviridae 10744|Podoviridae S ATPase activity - - - - - - - - - - - - - k59_90848_1 1205680.CAKO01000042_gene5487 1.72e-15 79.0 28MEU@1|root,2ZASF@2|Bacteria,1R7N3@1224|Proteobacteria 1224|Proteobacteria S TIGRFAM Phage recombination protein Bet - - - - - - - - - - - - RecT k59_215416_1 1636270.A0A0E3JPE0_9CAUD 3.61e-07 53.9 4QBI1@10239|Viruses,4QPC5@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_92500_1 658401.C7F4C0_9CAUD 5.79e-13 73.6 4QC3V@10239|Viruses,4QVEJ@35237|dsDNA viruses no RNA stage,4QT4B@28883|Caudovirales,4QMPJ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_293925_1 755732.Fluta_0539 9.25e-11 67.0 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - Big_3,CHU_C,DUF285,Gram_pos_anchor,SprB,Trypsin,VCBS k59_131341_1 1121098.HMPREF1534_01082 2.59e-31 125.0 COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,2FKYT@200643|Bacteroidia,4AQVC@815|Bacteroidaceae 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_333248_3 469383.Cwoe_4526 3.18e-54 199.0 COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4CPQY@84995|Rubrobacteria 84995|Rubrobacteria L type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_253133_1 478749.BRYFOR_07634 1.15e-09 66.2 COG4675@1|root,COG4675@2|Bacteria,1VDP2@1239|Firmicutes,24P8K@186801|Clostridia 186801|Clostridia S tail collar domain protein - - - - - - - - - - - - - k59_294339_1 585.DR95_513 5.16e-27 112.0 28JXH@1|root,2Z9MZ@2|Bacteria,1MXNC@1224|Proteobacteria,1RNI6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RecT family STY2074 - - - - - - - - - - - RecT k59_38295_1 429009.Adeg_0118 3.37e-06 49.3 COG1476@1|root,COG1476@2|Bacteria,1UV40@1239|Firmicutes,24RHZ@186801|Clostridia,42HK5@68295|Thermoanaerobacterales 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_400753_1 656519.Halsa_1443 2.46e-14 76.3 COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,3WAJP@53433|Halanaerobiales 186801|Clostridia NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_385498_2 1540092.A0A0A0RSY9_9CAUD 3.46e-34 127.0 4QC2T@10239|Viruses,4QPRB@28883|Caudovirales,4QNKM@10744|Podoviridae 10744|Podoviridae S transferase activity, transferring alkyl or aryl (other than methyl) groups - - - - - - - - - - - - - k59_199315_4 444859.E3SIB0_9CAUD 0.000693 49.3 4QCZH@10239|Viruses,4QPND@28883|Caudovirales,4QI11@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4 gp9/10-like protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_237511_1 345201.VF155_IIV3 2.73e-52 187.0 4QC2M@10239|Viruses,4QX3M@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_237511_3 345201.VF401_IIV3 2.28e-29 110.0 4QFI2@10239|Viruses,4QX08@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_267762_1 138119.DSY4361 6.82e-07 57.8 COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,260JQ@186807|Peptococcaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A,DNA_pol_A_exo1 k59_387539_1 1133293.H2EIC0_9CAUD 1.65e-21 99.4 4QAK6@10239|Viruses,4QXWJ@35237|dsDNA viruses no RNA stage,4QPID@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_188413_1 1123288.SOV_4c02780 1.28e-95 320.0 COG0503@1|root,COG0553@1|root,COG2263@1|root,COG3846@1|root,COG0503@2|Bacteria,COG0553@2|Bacteria,COG2263@2|Bacteria,COG3846@2|Bacteria,1TSYQ@1239|Firmicutes,4H5A6@909932|Negativicutes 909932|Negativicutes F protein secretion by the type IV secretion system - - - - - - - - - - - - SLT k59_335805_2 33035.JPJF01000122_gene2463 1.86e-11 67.8 COG0629@1|root,COG0629@2|Bacteria,1UI1P@1239|Firmicutes,24MGJ@186801|Clostridia,3Y1WA@572511|Blautia 186801|Clostridia L ERF superfamily - - - - - - - - - - - - ERF k59_255998_1 6326.BUX.s01376.13 3.94e-09 65.9 KOG1975@1|root,KOG1975@2759|Eukaryota,38B4C@33154|Opisthokonta,3BHH2@33208|Metazoa,3CXBF@33213|Bilateria,40BY7@6231|Nematoda,1KUFS@119089|Chromadorea 33208|Metazoa A Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family RNMT GO:0001510,GO:0001650,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004482,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005845,GO:0006139,GO:0006351,GO:0006366,GO:0006370,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008174,GO:0008757,GO:0009058,GO:0009059,GO:0009451,GO:0009452,GO:0009987,GO:0010033,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0031533,GO:0031974,GO:0031981,GO:0032259,GO:0032774,GO:0032991,GO:0034097,GO:0034518,GO:0034641,GO:0034645,GO:0034654,GO:0034708,GO:0036260,GO:0036265,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043235,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0070887,GO:0071310,GO:0071345,GO:0071704,GO:0080009,GO:0090304,GO:0097159,GO:0097659,GO:0106005,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:1990823,GO:1990830 2.1.1.56 ko:K00565 ko03015,map03015 - R03805 RC00003,RC00336 ko00000,ko00001,ko01000,ko03019 - - - Pox_MCEL k59_188427_2 40523.A8AT12_BPA51 5.84e-31 117.0 4QHN9@10239|Viruses,4QX1H@35237|dsDNA viruses no RNA stage,4QU3Z@28883|Caudovirales,4QJE6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_282606_1 316407.85676240 3.66e-110 320.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,3XNG2@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function, DUF484 yigA - - ko:K09921 - - - - ko00000 - - - DUF484 k59_430255_4 1548905.A0A0A1IUL8_9CAUD 2.5e-61 206.0 4QBA2@10239|Viruses,4QPPI@28883|Caudovirales,4QM0B@10699|Siphoviridae 10699|Siphoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_387569_1 691965.D4P7C5_9CAUD 5.64e-62 206.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_387574_1 290633.GOX2465 2.72e-29 115.0 COG3756@1|root,COG3935@1|root,COG3756@2|Bacteria,COG3935@2|Bacteria,1N481@1224|Proteobacteria 1224|Proteobacteria L Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_403496_1 1327990.S0A384_9CAUD 7.49e-53 186.0 4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses no RNA stage,4QR8A@28883|Caudovirales,4QNCV@10744|Podoviridae 10744|Podoviridae S nucleic acid binding - - - - - - - - - - - - - k59_256045_1 644283.Micau_6125 2.38e-07 58.2 COG4974@1|root,COG4974@2|Bacteria,2I4YF@201174|Actinobacteria,4DMUS@85008|Micromonosporales 201174|Actinobacteria L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase k59_188470_1 1123504.JQKD01000021_gene5682 2.59e-108 336.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_376472_1 269796.Rru_A1278 4.74e-20 91.3 28N1N@1|root,2ZB7Q@2|Bacteria,1R86T@1224|Proteobacteria,2U0A6@28211|Alphaproteobacteria,2JRMI@204441|Rhodospirillales 204441|Rhodospirillales H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_226432_1 1692244.A0A0K1RLR5_9CIRC 5.05e-69 221.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_256091_1 1589751.A0A0C5ABP5_9CAUD 1.51e-38 140.0 4QAIJ@10239|Viruses,4QPXI@28883|Caudovirales,4QM02@10699|Siphoviridae 10699|Siphoviridae S C-5 cytosine-specific DNA methylase - - - - - - - - - - - - - k59_404427_1 314230.DSM3645_28792 1.97e-11 72.0 COG1357@1|root,COG1357@2|Bacteria,2J2VS@203682|Planctomycetes 203682|Planctomycetes S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - - k59_336472_2 937777.Deipe_0444 5.5e-32 124.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_405452_2 745776.DGo_CA1901 9.67e-33 132.0 COG1566@1|root,COG5280@1|root,COG1566@2|Bacteria,COG5280@2|Bacteria 2|Bacteria NT Phage tail tape measure protein TP901 - - - ko:K02005,ko:K02022 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,PhageMin_Tail k59_311151_1 1234888.K0A2J2_9VIRU 1.64e-65 215.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_454_1 546273.VEIDISOL_01054 7.03e-27 112.0 COG5410@1|root,COG5410@2|Bacteria,1TSMG@1239|Firmicutes,4H6SR@909932|Negativicutes 909932|Negativicutes S TIGRFAM Phage - - - - - - - - - - - - - k59_243447_1 580332.Slit_2140 2.15e-30 112.0 COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,2VT1P@28216|Betaproteobacteria,44WFG@713636|Nitrosomonadales 28216|Betaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_162474_2 470.IX87_07880 8.58e-58 190.0 28IQ7@1|root,2Z8PY@2|Bacteria,1NA66@1224|Proteobacteria,1S212@1236|Gammaproteobacteria,3NMNM@468|Moraxellaceae 1236|Gammaproteobacteria S RecT family bet - - - - - - - - - - - RecT k59_270359_2 1123401.JHYQ01000005_gene265 8.62e-29 114.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,460NQ@72273|Thiotrichales 72273|Thiotrichales S PFAM 2OG-Fe(II) oxygenase superfamily - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_391833_2 411460.RUMTOR_01352 8.2e-37 129.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_189598_1 1589733.A0A0C5AMY2_9CAUD 3.56e-15 72.4 4QG13@10239|Viruses,4QSEQ@28883|Caudovirales,4QKCP@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_391985_1 1041826.FCOL_05440 3.44e-39 135.0 COG0270@1|root,COG0270@2|Bacteria,4P351@976|Bacteroidetes,1I9UJ@117743|Flavobacteriia,2NZ0G@237|Flavobacterium 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_365042_1 1403819.BATR01000122_gene4310 1.11e-06 58.5 COG3941@1|root,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - - k59_324547_2 742733.HMPREF9469_05062 3.28e-112 336.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia,222GT@1506553|Lachnoclostridium 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_271484_1 643648.Slip_0025 3.4e-16 80.9 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,1TSF5@1239|Firmicutes,25B5G@186801|Clostridia,42KKZ@68298|Syntrophomonadaceae 186801|Clostridia M TPR repeat - - - - - - - - - - - - ANAPC3,Glycos_transf_2,TPR_16,TPR_2,TPR_8 k59_271484_2 1230476.C207_01248 4.46e-93 285.0 COG0673@1|root,COG0673@2|Bacteria,1QTQ3@1224|Proteobacteria,2TVNA@28211|Alphaproteobacteria,3JX35@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain wbpB - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_271484_3 1051632.TPY_3673 1.03e-13 75.1 COG0110@1|root,COG1045@1|root,COG0110@2|Bacteria,COG1045@2|Bacteria,1TT21@1239|Firmicutes,24CCH@186801|Clostridia 186801|Clostridia M Bacterial transferase hexapeptide wbpD - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - Hexapep,Hexapep_2 k59_271484_4 42565.FP66_04570 7.61e-66 218.0 29UKS@1|root,30FY7@2|Bacteria,1RGKW@1224|Proteobacteria,1SKMS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_70198_2 1611039.A0A0C5C3Z3_9CIRC 9.17e-55 186.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_204737_2 1692242.A0A0K1RL37_9CIRC 1.23e-65 214.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_244908_1 469616.FMAG_02606 4.5e-40 144.0 COG0863@1|root,COG0863@2|Bacteria,37CTG@32066|Fusobacteria 32066|Fusobacteria L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_258326_1 1618238.A0A0C5IB41_9CIRC 3.49e-25 110.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_15505_1 1536774.H70357_05415 1.32e-12 78.2 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - DUF1080,Glyco_hydro_28,Pectate_lyase_3 k59_15505_2 1196323.ALKF01000193_gene3259 3.91e-50 180.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,26VXT@186822|Paenibacillaceae 91061|Bacilli O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 k59_123366_3 488538.SAR116_0383 5.34e-05 51.2 COG4675@1|root,COG4675@2|Bacteria,1Q0KH@1224|Proteobacteria,2UIYI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_204919_1 1121378.KB899742_gene3637 2.56e-12 72.8 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_204919_3 167555.NATL1_19741 3.58e-09 58.2 COG1403@1|root,COG1403@2|Bacteria,1G180@1117|Cyanobacteria,1MKDC@1212|Prochloraceae 1117|Cyanobacteria L HNH endonuclease family protein mcrA - - - - - - - - - - - HNH,HNH_5 k59_406958_1 324602.Caur_3769 2.6e-06 55.1 COG2152@1|root,COG3055@1|root,COG3266@1|root,COG5624@1|root,COG2152@2|Bacteria,COG3055@2|Bacteria,COG3266@2|Bacteria,COG5624@2|Bacteria,2G86G@200795|Chloroflexi,376E1@32061|Chloroflexia 32061|Chloroflexia G LamG domain protein jellyroll fold domain protein - - - - - - - - - - - - Laminin_G_3 k59_96651_1 1026970.XP_008830330.1 1.36e-13 81.3 28IWW@1|root,2QR8M@2759|Eukaryota,38G0N@33154|Opisthokonta,3BCJK@33208|Metazoa,3CUA0@33213|Bilateria,4879X@7711|Chordata,48XBD@7742|Vertebrata,3JEAF@40674|Mammalia,359TS@314146|Euarchontoglires,4Q0IE@9989|Rodentia 33208|Metazoa S Dyslexia-associated protein KIAA0319-like protein KIAA0319L GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0097708 - - - - - - - - - - REJ k59_96656_1 1556290.A0A0A0RLF5_9CAUD 4.18e-42 150.0 4QCWQ@10239|Viruses,4QQZU@28883|Caudovirales,4QMRV@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_70478_3 1355368.JART01000019_gene941 4.04e-17 80.1 COG3772@1|root,COG3772@2|Bacteria,1N0ZQ@1224|Proteobacteria,42XUI@68525|delta/epsilon subdivisions,2YQNY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_340074_1 1280954.HPO_06698 1.53e-06 50.8 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,43WY9@69657|Hyphomonadaceae 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family ccrM - 2.1.1.72 ko:K13581 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko02048 - - - N6_N4_Mtase k59_393156_1 247490.KSU1_C1049 1.31e-14 85.5 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_245086_2 1506994.JNLQ01000002_gene3180 4.89e-06 55.1 COG0438@1|root,COG2227@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria,1VBYX@1239|Firmicutes 1239|Firmicutes H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_217524_1 272568.GDI3669 2.84e-72 240.0 COG1783@1|root,COG1783@2|Bacteria,1RAGC@1224|Proteobacteria,2U6JF@28211|Alphaproteobacteria,2JSIA@204441|Rhodospirillales 204441|Rhodospirillales S phage Terminase large subunit - - - - - - - - - - - - - k59_70485_1 388051.AUFE01000035_gene4020 6.63e-34 131.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_177388_1 767817.Desgi_4495 0.000795 45.4 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,25E9Q@186801|Clostridia,262NR@186807|Peptococcaceae 186801|Clostridia D TIGRFAM phage tail tape measure protein, TP901 family, core region - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail k59_85695_1 1121105.ATXL01000006_gene1363 1.41e-09 60.5 2E3AH@1|root,32YA0@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1064) - - - - - - - - - - - - DUF1064 k59_44207_6 1562701.BBOF01000081_gene253 2.06e-79 253.0 28NGF@1|root,2Z9HT@2|Bacteria,1R9QF@1224|Proteobacteria,2VPSU@28216|Betaproteobacteria,1KD23@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_232363_2 272630.MexAM1_META1p4010 1.41e-22 97.8 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2UDUF@28211|Alphaproteobacteria,1JUC4@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PFAM glycoside hydrolase family 24 - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_246902_2 1589298.A0A0B5H8X5_9CAUD 5.2e-14 75.1 4QD6Y@10239|Viruses,4QPFN@28883|Caudovirales 28883|Caudovirales S DNA N-6-adenine-methyltransferase (Dam) - - - - - - - - - - - - - k59_380876_1 1618254.A0A0C5IBG4_9CIRC 3e-44 151.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_355565_1 1234888.K0A2J2_9VIRU 1.51e-45 162.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_85705_1 944479.JQLX01000013_gene1464 6.68e-10 63.9 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria,2M6VU@213113|Desulfurellales 28221|Deltaproteobacteria G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_408768_1 1433126.BN938_1267 1.29e-10 67.8 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,2FME3@200643|Bacteroidia,22U3U@171550|Rikenellaceae 976|Bacteroidetes M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_368174_3 1276227.SCHRY_v1c09020 3.41e-08 60.8 COG0358@1|root,COG0358@2|Bacteria,3WSZT@544448|Tenericutes 544448|Tenericutes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_111591_1 469383.Cwoe_1788 1.16e-28 124.0 COG4942@1|root,COG4942@2|Bacteria,2GP1Y@201174|Actinobacteria,4CPU0@84995|Rubrobacteria 84995|Rubrobacteria D Peptidase family M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_143019_2 571166.KI421509_gene3812 3.82e-34 124.0 28PMA@1|root,2ZCAD@2|Bacteria,1RARQ@1224|Proteobacteria,2U6X3@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_329917_2 1054968.G0X507_9CAUD 7.76e-42 148.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales,4QNNP@10744|Podoviridae 10744|Podoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_100796_1 682795.AciX8_1835 8.96e-30 124.0 COG4626@1|root,COG4626@2|Bacteria,3Y7XC@57723|Acidobacteria,2JMX4@204432|Acidobacteriia 204432|Acidobacteriia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_209850_1 28444.JODQ01000010_gene3201 6.14e-20 92.8 COG2453@1|root,COG2453@2|Bacteria,2IHXA@201174|Actinobacteria,4EJ4H@85012|Streptosporangiales 201174|Actinobacteria T Protein-tyrosine phosphatase - - - - - - - - - - - - Y_phosphatase k59_113353_2 327079.R9PFL1 3.42e-07 57.8 COG0631@1|root,COG1052@1|root,KOG0069@2759|Eukaryota,KOG0698@2759|Eukaryota 2759|Eukaryota T protein serine/threonine phosphatase activity MgPP2CL-1 GO:0000188,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0004724,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009628,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032872,GO:0032873,GO:0033549,GO:0033554,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043086,GO:0043170,GO:0043405,GO:0043407,GO:0043408,GO:0043409,GO:0043412,GO:0043549,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045859,GO:0045936,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070302,GO:0070303,GO:0071214,GO:0071470,GO:0071704,GO:0071900,GO:0071901,GO:0080090,GO:0080134,GO:0080135,GO:0104004,GO:0140096,GO:1900034,GO:1901564,GO:1902531,GO:1902532,GO:1990439 1.1.1.26,3.1.3.16 ko:K00015,ko:K01090,ko:K19704 ko00630,ko01100,ko01110,ko01120,ko04011,map00630,map01100,map01110,map01120,map04011 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000,ko01009 - - - 2-Hacid_dh,2-Hacid_dh_C,PP2C k59_194524_1 428125.CLOLEP_00555 2.01e-16 85.9 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WGNQ@541000|Ruminococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_411176_1 1444310.JANV01000205_gene652 1.17e-17 88.2 COG0741@1|root,COG1196@1|root,COG4942@1|root,COG0741@2|Bacteria,COG1196@2|Bacteria,COG4942@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1ZH33@1386|Bacillus 91061|Bacilli M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k59_5791_2 649747.HMPREF0083_01053 2.77e-20 95.5 COG5377@1|root,COG5377@2|Bacteria,1TS2Y@1239|Firmicutes,4HAFK@91061|Bacilli,26XTJ@186822|Paenibacillaceae 91061|Bacilli L YqaJ-like viral recombinase domain yqaJ - - - - - - - - - - - YqaJ k59_88105_1 675806.VII_003784 8.84e-12 66.6 COG1196@1|root,COG1196@2|Bacteria,1PPPK@1224|Proteobacteria,1TJ76@1236|Gammaproteobacteria,1Y0QY@135623|Vibrionales 135623|Vibrionales D nuclear chromosome segregation - - - - - - - - - - - - - k59_154643_1 1042163.BRLA_c031170 9.48e-22 100.0 COG4373@1|root,COG4373@2|Bacteria,1TQNK@1239|Firmicutes,4HDES@91061|Bacilli,26WPR@186822|Paenibacillaceae 91061|Bacilli S Mu-like prophage FluMu protein gp28 gp17a - - - - - - - - - - - Terminase_6,Terminase_6C k59_318559_3 742740.HMPREF9474_02274 1.21e-32 119.0 2DHA9@1|root,32U8X@2|Bacteria,1VD44@1239|Firmicutes,24NC3@186801|Clostridia,222SC@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_318559_5 665956.HMPREF1032_00668 5.12e-51 166.0 2AIHK@1|root,318ZG@2|Bacteria,1V7P0@1239|Firmicutes,24KNU@186801|Clostridia,3WNH7@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_318559_6 691965.D4P7B9_9CAUD 6.53e-33 118.0 4QFDH@10239|Viruses,4QWV5@35237|dsDNA viruses no RNA stage,4QPB8@28883|Caudovirales,4QKNN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_370005_1 613026.HRAG_00073 3.2e-20 93.6 2B2B4@1|root,31UV7@2|Bacteria,1R16D@1224|Proteobacteria 1224|Proteobacteria S Glycosyltransferase family 10 (fucosyltransferase) C-term - - - - - - - - - - - - Glyco_transf_10 k59_302822_1 1276257.SSABA_v1c08340 7.05e-09 61.2 COG0143@1|root,COG0143@2|Bacteria,3WSXZ@544448|Tenericutes 544448|Tenericutes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g k59_361291_3 1120792.JAFV01000001_gene1676 7.37e-45 156.0 COG3926@1|root,COG3926@2|Bacteria,1QV3R@1224|Proteobacteria,2UDA8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glycosyl hydrolase 108 - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_35972_1 1283340.Q6WHK5_BPKVM 2.11e-13 81.6 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_35972_3 526222.Desal_1848 3.02e-21 90.5 2DMPB@1|root,32SV8@2|Bacteria,1NHUE@1224|Proteobacteria,430VU@68525|delta/epsilon subdivisions,2WW0U@28221|Deltaproteobacteria,2MCJ3@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_413249_3 1121285.AUFK01000013_gene2368 7.93e-08 55.8 COG3409@1|root,COG3409@2|Bacteria,4PPJM@976|Bacteroidetes,1IKP5@117743|Flavobacteriia,3ZUK3@59732|Chryseobacterium 976|Bacteroidetes M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_79258_1 1089551.KE386572_gene902 8.02e-28 124.0 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity yvcI - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,TMP-TENI k59_413256_1 1337093.MBE-LCI_1558 2.64e-33 120.0 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_8082_2 1536772.R70723_03290 5.17e-27 107.0 COG0175@1|root,COG0175@2|Bacteria,1TQBQ@1239|Firmicutes,4HD3W@91061|Bacilli,270CN@186822|Paenibacillaceae 91061|Bacilli EH sulfate reduction - - - - - - - - - - - - - k59_361312_2 105154.Q9MBU3_9VIRU 3.12e-22 97.4 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_371884_2 68170.KL590469_gene1601 9.74e-05 47.0 COG1051@1|root,COG1051@2|Bacteria,2I8YY@201174|Actinobacteria,4E2M5@85010|Pseudonocardiales 201174|Actinobacteria F NUDIX domain - - - - - - - - - - - - NUDIX k59_413265_1 1357279.N018_05425 2.65e-24 106.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1SMCU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_425508_1 335283.Neut_1455 4.37e-54 195.0 COG2304@1|root,COG4733@1|root,COG2304@2|Bacteria,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,2VJS7@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_22359_1 1476888.X4YGV1_9CAUD 7.59e-18 79.0 4QBBW@10239|Viruses,4QXCP@35237|dsDNA viruses no RNA stage,4QQ3N@28883|Caudovirales,4QN1X@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_22359_2 742740.HMPREF9474_02267 5.17e-34 123.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia,221N8@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_50977_1 1248232.BANQ01000117_gene1794 0.000526 48.1 COG4974@1|root,COG4974@2|Bacteria,1R7M0@1224|Proteobacteria,1RYKU@1236|Gammaproteobacteria,1XVH0@135623|Vibrionales 135623|Vibrionales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_223303_1 1121934.AUDX01000030_gene1226 1.16e-64 210.0 COG0270@1|root,COG0270@2|Bacteria,2I8R8@201174|Actinobacteria 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_185194_1 1788452.A0A190WHG0_9CIRC 4.07e-06 53.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_105082_1 883126.HMPREF9710_00473 3.41e-09 62.4 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2VNZ1@28216|Betaproteobacteria,475PJ@75682|Oxalobacteraceae 28216|Betaproteobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux k59_415328_2 1410634.JHVD01000028_gene2102 7.18e-34 121.0 2CXZV@1|root,32T32@2|Bacteria,2H6AB@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_253001_1 316275.VSAL_I0780 1.3e-06 48.9 2CPEB@1|root,32SIW@2|Bacteria,1MZE0@1224|Proteobacteria,1SARU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_307623_1 272134.KB731324_gene2720 8.75e-30 122.0 COG1783@1|root,COG4373@1|root,COG1783@2|Bacteria,COG4373@2|Bacteria 2|Bacteria S DNA packaging xtmB - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C,Terminase_6,Terminase_6C k59_400628_1 1211813.CAPH01000018_gene1017 1.55e-21 102.0 COG0507@1|root,COG0507@2|Bacteria,4NF6J@976|Bacteroidetes,2FM19@200643|Bacteroidia 976|Bacteroidetes L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member uvrD2 - - - - - - - - - - - HRDC,HTH_40,Herpes_Helicase,PIF1,UvrD_C_2 k59_185209_1 440250.A5HL29_9CAUD 1.87e-18 82.4 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_185209_2 548479.HMPREF0573_11392 1.5e-19 89.0 COG4695@1|root,COG4695@2|Bacteria,2IE2H@201174|Actinobacteria,4D5XF@85005|Actinomycetales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_199415_1 55601.VANGNB10_cI1598c 8.8e-42 141.0 2DNA4@1|root,32WDI@2|Bacteria,1RH8K@1224|Proteobacteria,1S8YN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage tail tube, TTP, lambda-like - - - - - - - - - - - - Phage_TTP_11 k59_199415_2 1388763.O165_006580 7.88e-19 84.3 2CHRA@1|root,32S6D@2|Bacteria,1MZ8I@1224|Proteobacteria,1SHSQ@1236|Gammaproteobacteria,1YYT0@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Phage tail assembly chaperone, TAC - - - - - - - - - - - - Phage_TAC_13 k59_131721_2 1123269.NX02_21950 1.87e-27 123.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,2K42P@204457|Sphingomonadales 204457|Sphingomonadales S Terminase - - - - - - - - - - - - Terminase_1 k59_24532_2 292459.STH1808 6.85e-07 50.8 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia 186801|Clostridia V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_237519_4 1280390.CBQR020000085_gene1840 8.25e-35 130.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli,26S1K@186822|Paenibacillaceae 91061|Bacilli E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_373768_1 565575.UUR10_0459 0.000138 50.1 COG0258@1|root,COG0258@2|Bacteria,3WT2S@544448|Tenericutes 544448|Tenericutes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_294476_1 1353537.TP2_17750 1.2e-37 146.0 COG1961@1|root,COG1961@2|Bacteria,1MV0C@1224|Proteobacteria,2TTJT@28211|Alphaproteobacteria,2XKGI@285107|Thioclava 28211|Alphaproteobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_227820_1 1465751.W8QE57_9VIRU 5.12e-141 406.0 4QC2G@10239|Viruses,4QV3V@35237|dsDNA viruses no RNA stage 10239|Viruses S Ribonucleotide reductase, small chain - - - - - - - - - - - - - k59_336799_1 99158.XP_008883176.1 0.000127 50.1 COG0553@1|root,KOG0384@2759|Eukaryota,3Y9PD@5794|Apicomplexa,3YNP3@5796|Coccidia,3YRAB@5809|Sarcocystidae 5794|Apicomplexa K Chromodomain helicase DNA binding protein - GO:0001650,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006325,GO:0006355,GO:0006357,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016043,GO:0016462,GO:0016569,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032392,GO:0032508,GO:0035064,GO:0035821,GO:0042393,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043900,GO:0043902,GO:0043903,GO:0043921,GO:0043923,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046782,GO:0048518,GO:0048524,GO:0050434,GO:0050789,GO:0050792,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0051702,GO:0051704,GO:0051817,GO:0051851,GO:0052312,GO:0052472,GO:0060255,GO:0065007,GO:0070013,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0140030,GO:0140034,GO:0140097,GO:1903506,GO:2000112,GO:2001141 3.6.4.12 ko:K11367 - - - - ko00000,ko01000,ko03021,ko03036 - - - Chromo,DUF4208,Helicase_C,SNF2_N k59_240585_2 2003327.CAPSD_BPCHP 6.16e-26 116.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_336828_1 279303.Q6J7X1_9CAUD 5.78e-37 141.0 4QCM9@10239|Viruses,4QVZV@35237|dsDNA viruses no RNA stage,4QTYN@28883|Caudovirales,4QMZ7@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_336859_1 691965.D4P7I3_9CAUD 3.39e-64 220.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_68838_3 1381123.AYOD01000025_gene1521 5.81e-11 70.5 COG3409@1|root,COG3409@2|Bacteria,1RFU4@1224|Proteobacteria,2U8C1@28211|Alphaproteobacteria,43I6Q@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M N-acetylmuramidase - - - - - - - - - - - - Muraidase,PG_binding_1 k59_68838_4 398578.Daci_3412 1.26e-24 100.0 COG2131@1|root,COG2131@2|Bacteria,1PNTI@1224|Proteobacteria,2WC0G@28216|Betaproteobacteria,4AINC@80864|Comamonadaceae 28216|Betaproteobacteria F MafB19-like deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_68838_11 661087.HMPREF1008_00105 1.13e-19 104.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CUSF@84998|Coriobacteriia 84998|Coriobacteriia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_68838_18 263815.XP_007872928.1 6.78e-10 65.5 COG3774@1|root,2QS3D@2759|Eukaryota,395GM@33154|Opisthokonta,3NUR1@4751|Fungi,3QJH4@4890|Ascomycota,3MDP3@451866|Taphrinomycotina 4751|Fungi G Mannosyltransferase CSH1 GO:0000030,GO:0000139,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005783,GO:0005789,GO:0005794,GO:0005801,GO:0005802,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006665,GO:0006673,GO:0006675,GO:0006687,GO:0006688,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009247,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0030148,GO:0031090,GO:0031224,GO:0031501,GO:0031984,GO:0032588,GO:0032991,GO:0033106,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046467,GO:0051999,GO:0070085,GO:0071704,GO:0090407,GO:0097502,GO:0098588,GO:0098791,GO:0098805,GO:0098827,GO:0098852,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1903509,GO:1990234 - - - - - - - - - - Gly_transf_sug k59_68838_20 1392838.AWNM01000039_gene824 7.03e-19 98.2 COG0457@1|root,COG0463@1|root,COG2520@1|root,COG3914@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,COG2520@2|Bacteria,COG3914@2|Bacteria,1RBHD@1224|Proteobacteria,2VTUR@28216|Betaproteobacteria 28216|Betaproteobacteria M O-linked N-acetylglucosamine transferase SPINDLY family - - - - - - - - - - - - - k59_68838_23 1267211.KI669560_gene2038 1.56e-19 91.7 COG0847@1|root,COG0847@2|Bacteria,4NE82@976|Bacteroidetes,1IPA8@117747|Sphingobacteriia 976|Bacteroidetes L DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_68838_24 1047013.AQSP01000054_gene254 2.3e-25 101.0 COG0756@1|root,COG0756@2|Bacteria,2NPXR@2323|unclassified Bacteria 2|Bacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_68838_25 65393.PCC7424_0754 2.39e-05 47.4 COG2452@1|root,COG2452@2|Bacteria,1G1T5@1117|Cyanobacteria,3KIKB@43988|Cyanothece 1117|Cyanobacteria L regulatory protein, MerR - - - - - - - - - - - - MerR,MerR_1,Resolvase k59_82261_1 716544.wcw_0164 2.21e-25 103.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity ubiE8 - - - - - - - - - - - LicD,Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_82261_3 1175654.A0A0S0NAG1_9CAUD 3.67e-09 59.7 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales 28883|Caudovirales S protein disulfide oxidoreductase activity - - - - - - - - - - - - - k59_419178_1 626887.J057_01900 7.42e-08 55.8 2C2XN@1|root,32GT6@2|Bacteria,1REZE@1224|Proteobacteria,1SG9Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_419178_2 1265502.KB905977_gene528 5.35e-18 80.5 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,4AIQ3@80864|Comamonadaceae 28216|Betaproteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_41753_1 742733.HMPREF9469_05020 8.89e-126 423.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_41753_2 478749.BRYFOR_08514 1.28e-27 105.0 2ARVA@1|root,31H70@2|Bacteria,1V7JT@1239|Firmicutes,24JPE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - HK97-gp10_like k59_41753_3 742733.HMPREF9469_05023 2.23e-36 132.0 2CGG9@1|root,2ZVSJ@2|Bacteria,1V633@1239|Firmicutes,24HD0@186801|Clostridia,222RY@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_176402_9 1116232.AHBF01000043_gene2915 3.57e-05 53.5 COG0739@1|root,COG0739@2|Bacteria,2GMJB@201174|Actinobacteria 201174|Actinobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_203934_30 1382306.JNIM01000001_gene276 5.13e-11 72.0 COG0741@1|root,COG0741@2|Bacteria 2|Bacteria M lytic transglycosylase activity - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - Peptidase_M23,SLT,TMP_2 k59_203934_32 1232447.BAHW02000034_gene2521 4.37e-06 53.1 COG1925@1|root,COG1925@2|Bacteria,1VHJ4@1239|Firmicutes,24RNG@186801|Clostridia 186801|Clostridia G phosphoenolpyruvate-dependent sugar phosphotransferase system - - - - - - - - - - - - - k59_203934_33 1165094.RINTHH_19570 1.11e-06 53.9 COG2389@1|root,COG2389@2|Bacteria,1G6XV@1117|Cyanobacteria,1HKET@1161|Nostocales 1117|Cyanobacteria S metal-binding protein - - - - - - - - - - - - DUF2227 k59_203934_34 97138.C820_00589 9.11e-50 171.0 COG0863@1|root,COG0863@2|Bacteria,1V0ZF@1239|Firmicutes,24CQV@186801|Clostridia,36J76@31979|Clostridiaceae 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_203934_36 633149.Bresu_1372 3.26e-14 71.2 COG2411@1|root,COG2411@2|Bacteria,1R0A7@1224|Proteobacteria,2TYPE@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_203934_44 1123322.KB904676_gene3072 1.03e-48 161.0 COG0720@1|root,COG0720@2|Bacteria,2IJ3A@201174|Actinobacteria 201174|Actinobacteria H synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_203934_46 1453496.AT03_16310 1.08e-52 176.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_203934_47 106370.Francci3_1748 2.24e-58 188.0 COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4ERHB@85013|Frankiales 201174|Actinobacteria H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_203934_52 1144325.PMI22_04835 2.24e-15 82.8 COG0438@1|root,COG3551@1|root,COG3754@1|root,COG5610@1|root,COG0438@2|Bacteria,COG3551@2|Bacteria,COG3754@2|Bacteria,COG5610@2|Bacteria,1RB2G@1224|Proteobacteria 1224|Proteobacteria D Protein conserved in bacteria - - - - - - - - - - - - Sulfotransfer_3 k59_203934_60 1294143.H681_08485 7.68e-20 100.0 COG1216@1|root,COG1216@2|Bacteria,1N2VJ@1224|Proteobacteria 1224|Proteobacteria M Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1,Glycos_transf_2 k59_203934_69 990285.RGCCGE502_22705 7.07e-36 155.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2U1H4@28211|Alphaproteobacteria,4BCD7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage-related minor tail protein - - - - - - - - - - - - Peptidase_M15_3,PhageMin_Tail k59_379825_2 547045.NEISICOT_01693 4.76e-22 106.0 COG0714@1|root,COG0714@2|Bacteria,1PM35@1224|Proteobacteria,2VM64@28216|Betaproteobacteria,2KRK7@206351|Neisseriales 206351|Neisseriales S AAA domain (dynein-related subfamily) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5 k59_231141_1 879212.DespoDRAFT_01372 6.27e-06 55.1 COG5434@1|root,COG5434@2|Bacteria,1R4PA@1224|Proteobacteria,42NNP@68525|delta/epsilon subdivisions,2WMC2@28221|Deltaproteobacteria,2MIHE@213118|Desulfobacterales 28221|Deltaproteobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_340143_4 543632.JOJL01000011_gene7009 1.38e-56 212.0 COG3740@1|root,COG4695@1|root,COG3740@2|Bacteria,COG4695@2|Bacteria,2HEYI@201174|Actinobacteria,4DGUS@85008|Micromonosporales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_42947_5 1032480.MLP_13070 8.33e-07 61.6 COG0739@1|root,COG3021@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3021@2|Bacteria,COG3409@2|Bacteria,2IFNV@201174|Actinobacteria 201174|Actinobacteria M Peptidase family M23 - - - - - - - - - - - - PG_binding_1,Peptidase_M23 k59_313760_1 1692257.A0A0K1RL39_9CIRC 8.07e-38 139.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_420330_1 691965.D4P7L7_9CAUD 7.46e-98 318.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_96953_1 203124.Tery_2671 4.46e-88 283.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H7GW@1150|Oscillatoriales 1117|Cyanobacteria O Tetratricopeptide repeat - - - - - - - - - - - - CHAT,TPR_12,TPR_8 k59_29713_2 1232453.BAIF02000057_gene1135 1.08e-12 70.5 2CWXD@1|root,32T0J@2|Bacteria,1VCVP@1239|Firmicutes,24MPK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_56821_2 1121448.DGI_2053 1.5e-20 90.5 COG4653@1|root,COG4653@2|Bacteria,1MXMN@1224|Proteobacteria,42UKA@68525|delta/epsilon subdivisions,2WQZV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_191214_1 42565.FP66_10600 1.46e-24 101.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1XJ7F@135619|Oceanospirillales 135619|Oceanospirillales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_137977_2 237609.PSAKL28_17230 1.19e-41 142.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1S99W@1236|Gammaproteobacteria 1236|Gammaproteobacteria G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_83843_2 1198232.CYCME_0289 4.6e-13 77.0 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,1S2JP@1236|Gammaproteobacteria,460RX@72273|Thiotrichales 72273|Thiotrichales L ATP dependent DNA ligase domain - - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_164073_1 1506583.JQJY01000003_gene3401 0.000263 48.9 COG4695@1|root,COG4695@2|Bacteria,4NT34@976|Bacteroidetes 976|Bacteroidetes S Phage portal protein - - - - - - - - - - - - Phage_portal k59_343487_1 1041147.AUFB01000014_gene330 2.84e-14 74.3 2FIAW@1|root,34A38@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_317024_1 1453501.JELR01000001_gene2530 6.04e-53 181.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,1RPB0@1236|Gammaproteobacteria,467NH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Phage portal protein beeE - - - - - - - - - - - Phage_portal k59_317043_2 1122138.AQUZ01000012_gene5977 2.88e-06 50.8 COG3391@1|root,COG3391@2|Bacteria,2I2VV@201174|Actinobacteria,4DTEE@85009|Propionibacteriales 201174|Actinobacteria S amine dehydrogenase activity - - - - - - - - - - - - DUF5122,Laminin_G_3 k59_381480_1 72228.T5ALQ9 4.3e-38 150.0 28NC4@1|root,2QUXI@2759|Eukaryota,39UE4@33154|Opisthokonta,3NXTN@4751|Fungi,3QSJ8@4890|Ascomycota,218UM@147550|Sordariomycetes,3TFGR@5125|Hypocreales 4751|Fungi S phosphatase - - - - - - - - - - - - NTP_transferase k59_18372_1 1394178.AWOO02000006_gene3461 2.85e-10 62.8 2ADP2@1|root,313DZ@2|Bacteria,2GX82@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_45037_2 161528.ED21_30869 0.000163 45.8 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2U7X4@28211|Alphaproteobacteria 28211|Alphaproteobacteria G lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_125508_1 948870.I7I014_9CAUD 8.44e-17 87.0 4QAUT@10239|Viruses,4QVIM@35237|dsDNA viruses no RNA stage,4QQ7X@28883|Caudovirales,4QIGV@10662|Myoviridae 10662|Myoviridae S DNA ligase (ATP) activity - - - - - - - - - - - - - k59_125508_4 561231.Pecwa_1755 1.25e-15 73.9 28XPN@1|root,2ZJKF@2|Bacteria 2|Bacteria S Domain of unknown function (DUF1874) - - - - - - - - - - - - DUF1874 k59_86650_2 553218.CAMRE0001_2405 7.97e-44 157.0 COG0553@1|root,COG0553@2|Bacteria,1PM15@1224|Proteobacteria,42ZGS@68525|delta/epsilon subdivisions,2YS8B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DEAD-like helicases superfamily - - - - - - - - - - - - - k59_301559_1 1392838.AWNM01000004_gene1798 2.1e-90 285.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,3T3DM@506|Alcaligenaceae 28216|Betaproteobacteria S COG4626 Phage terminase-like protein, large subunit - - - - - - - - - - - - Terminase_1 k59_153493_1 351016.RAZWK3B_11957 0.000866 46.6 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2TS7K@28211|Alphaproteobacteria,2P3YC@2433|Roseobacter 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_127180_1 1537917.JU82_03700 3.31e-47 164.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII,SNF2_N k59_220366_1 291607.MREP_SCSVF 5.67e-16 82.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_423966_1 1121866.AUGK01000003_gene1402 9.4e-07 58.9 COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria 2|Bacteria L helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_359408_1 991.IW20_01125 2.49e-05 52.0 COG0739@1|root,COG0739@2|Bacteria,4NECF@976|Bacteroidetes,1HY2X@117743|Flavobacteriia,2NTB6@237|Flavobacterium 976|Bacteroidetes M peptidase - - - - - - - - - - - - Peptidase_M23 k59_88895_1 311402.Avi_2984 1.95e-08 65.1 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,4BIQV@82115|Rhizobiaceae 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_397259_16 1444306.JFZC01000026_gene2339 4.44e-28 119.0 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,26NY2@186821|Sporolactobacillaceae 91061|Bacilli M Transglycosylase SLT domain yjbJ - - - - - - - - - - - SLT k59_20502_2 2340.JV46_08150 1.81e-22 107.0 COG3291@1|root,COG3291@2|Bacteria,1PDUK@1224|Proteobacteria,1S8QS@1236|Gammaproteobacteria,1JBTK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PKD domain - - - - - - - - - - - - PKD,PPC,Peptidase_M43 k59_144373_2 1196083.SALWKB12_1250 1.52e-57 191.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,2KR09@206351|Neisseriales 206351|Neisseriales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_319732_1 349521.HCH_05649 2.97e-21 98.2 COG4733@1|root,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,1RRUV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_319732_3 762982.HMPREF9442_01222 2.8e-68 216.0 COG0863@1|root,COG0863@2|Bacteria,4NQQ1@976|Bacteroidetes 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_275963_1 237727.NAP1_12148 5.68e-05 50.4 2DSHN@1|root,33G5Q@2|Bacteria,1NGM3@1224|Proteobacteria,2UK0H@28211|Alphaproteobacteria,2K4KJ@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_168662_2 861450.HMPREF0080_02061 1.27e-14 72.8 COG0791@1|root,COG0791@2|Bacteria,1VFVZ@1239|Firmicutes,4H5Q7@909932|Negativicutes 909932|Negativicutes M NlpC/P60 family - - - - - - - - - - - - NLPC_P60 k59_345979_1 753085.F4YCR7_9CAUD 2.6e-16 87.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_91258_1 1090320.KB900605_gene2718 1.35e-07 62.8 COG5434@1|root,COG5434@2|Bacteria,1PH5I@1224|Proteobacteria,2V915@28211|Alphaproteobacteria,2KBX2@204457|Sphingomonadales 204457|Sphingomonadales M Pectate lyase superfamily protein - - - - - - - - - - - - Pectate_lyase_3 k59_91258_2 398578.Daci_1953 3.49e-71 243.0 28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_103675_1 439375.Oant_0230 1.12e-76 238.0 COG0270@1|root,COG0270@2|Bacteria,1R5MR@1224|Proteobacteria,2U53Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_399547_1 1465751.W8QF03_9VIRU 1.21e-94 313.0 4QB98@10239|Viruses,4QWE3@35237|dsDNA viruses no RNA stage 10239|Viruses S Glycosyl transferase family 90 - - - - - - - - - - - - - k59_251795_1 1429046.RR21198_0302 0.000901 44.3 2EC0B@1|root,335ZK@2|Bacteria,2I86C@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_8947_1 75379.Tint_2924 9.47e-81 254.0 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,2VISI@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM phage plasmid-related protein TIGR03299 - - - - - - - - - - - - DUF932 k59_49626_1 10726.Q6QGN6_BPT5 3.17e-36 130.0 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_63048_1 1123248.KB893317_gene4269 7.94e-08 61.2 COG4625@1|root,COG5295@1|root,COG4625@2|Bacteria,COG5295@2|Bacteria,4NF6Q@976|Bacteroidetes,1IQG8@117747|Sphingobacteriia 976|Bacteroidetes UW Right handed beta helix region - - - - - - - - - - - - Beta_helix,Big_3_3,M60-like_N,NosD,Peptidase_M60 k59_322616_1 546264.NEIFLAOT_01370 1.15e-12 75.5 COG5281@1|root,COG5283@1|root,COG5281@2|Bacteria,COG5283@2|Bacteria,1NWJI@1224|Proteobacteria,2VKT1@28216|Betaproteobacteria 28216|Betaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_277906_1 1618238.A0A0C5IB41_9CIRC 1.61e-20 95.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_80563_1 10116.ENSRNOP00000043623 1.9e-35 128.0 KOG0096@1|root,KOG0096@2759|Eukaryota,38BBN@33154|Opisthokonta,3BAB7@33208|Metazoa,3CTTW@33213|Bilateria,484N9@7711|Chordata,493VE@7742|Vertebrata,3J1US@40674|Mammalia,35FAV@314146|Euarchontoglires,4Q4A8@9989|Rodentia 33208|Metazoa U snRNA import into nucleus RAN GO:0000003,GO:0000054,GO:0000070,GO:0000132,GO:0000166,GO:0000212,GO:0000226,GO:0000278,GO:0000280,GO:0000287,GO:0000819,GO:0001654,GO:0001673,GO:0001882,GO:0001883,GO:0002177,GO:0003006,GO:0003407,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005049,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005819,GO:0005856,GO:0005874,GO:0005876,GO:0005929,GO:0005938,GO:0006139,GO:0006163,GO:0006403,GO:0006404,GO:0006405,GO:0006606,GO:0006611,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007059,GO:0007163,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007292,GO:0007346,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008104,GO:0008150,GO:0008152,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009892,GO:0009987,GO:0010033,GO:0010468,GO:0010605,GO:0010608,GO:0010629,GO:0012505,GO:0014070,GO:0015031,GO:0015630,GO:0015833,GO:0015931,GO:0016043,GO:0016441,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017038,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019637,GO:0019693,GO:0019904,GO:0019953,GO:0021537,GO:0021543,GO:0021761,GO:0021766,GO:0022402,GO:0022412,GO:0022414,GO:0022613,GO:0030010,GO:0030154,GO:0030900,GO:0031047,GO:0031503,GO:0031514,GO:0031960,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032386,GO:0032388,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032870,GO:0032879,GO:0032880,GO:0032991,GO:0033036,GO:0033157,GO:0033365,GO:0033750,GO:0033993,GO:0034504,GO:0034613,GO:0034641,GO:0035068,GO:0035194,GO:0035195,GO:0035281,GO:0035639,GO:0036094,GO:0036126,GO:0040001,GO:0040029,GO:0042221,GO:0042254,GO:0042272,GO:0042278,GO:0042886,GO:0042995,GO:0043010,GO:0043073,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043393,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0044877,GO:0045184,GO:0045505,GO:0046039,GO:0046128,GO:0046483,GO:0046822,GO:0046824,GO:0046825,GO:0046827,GO:0046872,GO:0046907,GO:0048232,GO:0048285,GO:0048468,GO:0048477,GO:0048513,GO:0048515,GO:0048518,GO:0048519,GO:0048545,GO:0048609,GO:0048731,GO:0048856,GO:0048869,GO:0050657,GO:0050658,GO:0050789,GO:0050794,GO:0050896,GO:0051030,GO:0051049,GO:0051050,GO:0051098,GO:0051168,GO:0051169,GO:0051170,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051236,GO:0051276,GO:0051293,GO:0051294,GO:0051321,GO:0051385,GO:0051640,GO:0051641,GO:0051649,GO:0051653,GO:0051656,GO:0051704,GO:0051716,GO:0051726,GO:0055086,GO:0060041,GO:0060255,GO:0060322,GO:0060341,GO:0061015,GO:0061676,GO:0065007,GO:0065009,GO:0070013,GO:0070201,GO:0070727,GO:0070883,GO:0070887,GO:0071166,GO:0071310,GO:0071383,GO:0071384,GO:0071389,GO:0071396,GO:0071407,GO:0071426,GO:0071428,GO:0071495,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072521,GO:0072594,GO:0072686,GO:0090087,GO:0090316,GO:0097159,GO:0097223,GO:0097367,GO:0097729,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099568,GO:0120025,GO:0140014,GO:0140104,GO:0140142,GO:1901068,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901657,GO:1902850,GO:1903046,GO:1903047,GO:1903827,GO:1903829,GO:1904951,GO:1990498,GO:1990904 - ko:K07936 ko03008,ko03013,ko05166,ko05169,map03008,map03013,map05166,map05169 - - - ko00000,ko00001,ko03009,ko03016,ko03019,ko03036,ko04031,ko04147 - - - Ras k59_103893_1 1133022.I6NPA3_9CAUD 1.26e-35 139.0 4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_236561_1 4577.GRMZM2G358236_P01 5.56e-21 99.4 28ZYQ@1|root,2R6TI@2759|Eukaryota,37R3C@33090|Viridiplantae,3GH9I@35493|Streptophyta 35493|Streptophyta L DNA-directed DNA polymerase activity - - - - - - - - - - - - DNA_pol_B_2 k59_384687_1 1237149.C900_05366 1.94e-15 80.5 COG3740@1|root,COG3740@2|Bacteria,4NDXV@976|Bacteroidetes,47V54@768503|Cytophagia 976|Bacteroidetes S Phage prohead protease, HK97 family - - - - - - - - - - - - Peptidase_S78 k59_251823_1 1121875.KB907546_gene2239 3.86e-20 82.8 arCOG05253@1|root,31CTK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - YmaF k59_251823_2 926559.JoomaDRAFT_0569 7.84e-06 50.4 COG2020@1|root,COG2020@2|Bacteria,4NTAC@976|Bacteroidetes,1I4A9@117743|Flavobacteriia 976|Bacteroidetes O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_222221_1 1114179.I2FLT5_9CAUD 7.99e-08 59.3 4QAK6@10239|Viruses,4QVYZ@35237|dsDNA viruses no RNA stage,4QUA0@28883|Caudovirales,4QNI0@10744|Podoviridae 10744|Podoviridae S viral capsid - GO:0005575,GO:0019012,GO:0019028,GO:0019030,GO:0039617,GO:0044423,GO:0046729 - - - - - - - - - - - k59_160460_2 1336245.JAGO01000015_gene2117 4.77e-45 180.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_401315_2 984262.SGRA_2470 4.54e-09 59.7 COG1595@1|root,COG1595@2|Bacteria,4NMC0@976|Bacteroidetes,1IQKN@117747|Sphingobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_38905_4 1172188.KB911820_gene2858 3.19e-10 73.6 COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2IGMV@201174|Actinobacteria 201174|Actinobacteria M Transglycosylase SLT domain - - - - - - - - - - - - PG_binding_1,SLT,T7SS_ESX_EspC k59_51719_1 330779.Saci_1734 1.79e-42 150.0 COG1562@1|root,arCOG02936@2157|Archaea,2XRY6@28889|Crenarchaeota 28889|Crenarchaeota I Squalene/phytoene synthase - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_308486_1 1121097.JCM15093_741 7.77e-55 193.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,4P0VD@976|Bacteroidetes,2FMKK@200643|Bacteroidia,4AMUT@815|Bacteroidaceae 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2,Toprim_4 k59_416113_1 1463885.KL578353_gene8479 0.000258 45.8 2CC1Y@1|root,2ZN9E@2|Bacteria,2GVUD@201174|Actinobacteria 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA - - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_10815_6 760568.Desku_0784 6.78e-41 142.0 2CDFK@1|root,2Z8BH@2|Bacteria,1V43D@1239|Firmicutes,24KG0@186801|Clostridia 186801|Clostridia H DNA N-6-adenine-methyltransferase - - - - - - - - - - - - Dam k59_118194_1 1166948.JPZL01000001_gene3142 3.31e-21 99.4 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,1XH5K@135619|Oceanospirillales 135619|Oceanospirillales L helicase superfamily c-terminal domain - - - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII k59_401328_1 1475143.W8SNN0_9CIRC 8.56e-32 122.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_268395_1 7029.ACYPI001281-PA 2.44e-21 101.0 COG4870@1|root,KOG1543@2759|Eukaryota,38F8F@33154|Opisthokonta,3BI1S@33208|Metazoa,3CS39@33213|Bilateria,41UQT@6656|Arthropoda,3SKPK@50557|Insecta,3EC7R@33342|Paraneoptera 33208|Metazoa O Papain family cysteine protease - - 3.4.22.1 ko:K01363 ko04140,ko04142,ko04210,ko04612,ko04621,ko04924,map04140,map04142,map04210,map04612,map04621,map04924 - - - ko00000,ko00001,ko00536,ko01000,ko01002,ko03110,ko04147 - - - Peptidase_C1,Propeptide_C1 k59_223939_1 1121459.AQXE01000001_gene2751 2.24e-34 130.0 28IR7@1|root,2Z8QR@2|Bacteria,1PBTP@1224|Proteobacteria,42Z7V@68525|delta/epsilon subdivisions,2WTZ3@28221|Deltaproteobacteria,2M8NA@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_237836_1 946235.CAER01000065_gene2447 1.14e-60 209.0 COG4626@1|root,COG4626@2|Bacteria,1TPU1@1239|Firmicutes,4HAXI@91061|Bacilli,23KI0@182709|Oceanobacillus 91061|Bacilli S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_105876_1 652103.Rpdx1_2969 1.15e-09 62.8 COG0237@1|root,COG0237@2|Bacteria,1NEFS@1224|Proteobacteria 1224|Proteobacteria H dephospho-CoA kinase activity - - - - - - - - - - - - - k59_428219_1 1304865.JAGF01000001_gene1953 0.000656 50.8 COG3291@1|root,COG4625@1|root,COG3291@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF1080,He_PIG,PATR,SprB k59_333985_9 563123.B5U5I0_9CAUD 2.1e-12 70.1 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QKM7@10699|Siphoviridae 10699|Siphoviridae S HNH endonuclease - - - - - - - - - - - - - k59_333985_10 1288083.AUKR01000024_gene3453 2.91e-19 91.7 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_132967_1 691965.D4P7I3_9CAUD 6.51e-49 176.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_388525_2 1232410.KI421417_gene2759 4.71e-39 135.0 2DQTN@1|root,338M2@2|Bacteria,1NBQ0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_388525_3 1217714.F975_01644 2.81e-14 75.5 2AFJZ@1|root,315KW@2|Bacteria,1PVSA@1224|Proteobacteria,1SRGK@1236|Gammaproteobacteria,3NN72@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_336750_1 999413.HMPREF1094_02026 7.32e-47 164.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes 1239|Firmicutes L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_336750_2 1280692.AUJL01000044_gene2346 2.62e-48 174.0 COG0553@1|root,COG0553@2|Bacteria,1TP2C@1239|Firmicutes,24DVA@186801|Clostridia,36FNM@31979|Clostridiaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_241955_1 1046714.AMRX01000006_gene3194 2.44e-38 148.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_390335_1 319003.Bra1253DRAFT_08459 1.77e-08 61.6 2F5DG@1|root,33XZC@2|Bacteria,1RKCR@1224|Proteobacteria,2UBMH@28211|Alphaproteobacteria,3K2MH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_390348_1 716928.AJQT01000109_gene1217 4.89e-36 128.0 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_242028_2 1038860.AXAP01000067_gene8427 1.23e-16 82.8 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_242034_1 546274.EIKCOROL_02492 5.4e-18 85.9 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,2KPCE@206351|Neisseriales 206351|Neisseriales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_242095_2 443152.MDG893_20574 3.02e-16 75.1 2CHRA@1|root,32S6D@2|Bacteria,1MZ8I@1224|Proteobacteria,1SHSQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage tail assembly chaperone, TAC - - - - - - - - - - - - Phage_TAC_13 k59_324766_1 672.VV93_v1c15410 1.81e-62 207.0 2CI0W@1|root,2Z81W@2|Bacteria,1R9FZ@1224|Proteobacteria,1S0NA@1236|Gammaproteobacteria,1XW6F@135623|Vibrionales 135623|Vibrionales S Phage replication protein CRI - - - - - - - - - - - - Phage_CRI,Phage_X k59_257146_1 862517.HMPREF9225_0468 4.71e-16 85.5 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,22GDX@1570339|Peptoniphilaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_135888_1 338963.Pcar_2805 1.06e-06 52.0 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - HNH,HNH_5,Helicase_C,ResIII k59_135888_2 173824.Q9HH54_9CAUD 1.72e-13 73.9 4QH67@10239|Viruses,4QXEE@35237|dsDNA viruses no RNA stage,4QTBT@28883|Caudovirales,4QMA5@10699|Siphoviridae 10699|Siphoviridae S Terminase-like family - - - - - - - - - - - - - k59_189715_1 1027273.GZ77_18495 6.57e-63 206.0 COG0675@1|root,COG0675@2|Bacteria,1MUU0@1224|Proteobacteria,1RY56@1236|Gammaproteobacteria,1XQZ0@135619|Oceanospirillales 135619|Oceanospirillales L Probable transposase - - - - - - - - - - - - OrfB_IS605,OrfB_Zn_ribbon k59_41693_1 1128073.G9LQV7_9CIRC 1.67e-55 182.0 4QBIP@10239|Viruses,4QUKB@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_68830_1 1537917.JU82_03700 5.86e-62 202.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII,SNF2_N k59_338534_1 944565.HMPREF9127_0706 1.32e-13 75.9 COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,22GDR@1570339|Peptoniphilaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_257380_1 1506583.JQJY01000003_gene3401 5.94e-15 81.3 COG4695@1|root,COG4695@2|Bacteria,4NT34@976|Bacteroidetes 976|Bacteroidetes S Phage portal protein - - - - - - - - - - - - Phage_portal k59_176305_2 626887.J057_01900 7.47e-08 59.3 2C2XN@1|root,32GT6@2|Bacteria,1REZE@1224|Proteobacteria,1SG9Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_28270_4 658612.MD26_15610 2.86e-05 48.1 COG3108@1|root,COG3108@2|Bacteria,1N1HE@1224|Proteobacteria,1SCII@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase M15A - - - - - - - - - - - - Peptidase_M15_3 k59_162996_2 1415148.V5Q7C9_9CAUD 0.000107 45.1 4QC1H@10239|Viruses,4QZJZ@35237|dsDNA viruses no RNA stage,4QU36@28883|Caudovirales,4QN15@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_244020_2 1388763.O165_022250 4.31e-15 75.1 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria 1224|Proteobacteria K Terminase - - - - - - - - - - - - Terminase_1 k59_338556_1 1379713.S5SYD9_9CIRC 5.65e-13 73.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_95576_1 1121353.H924_07255 7.53e-25 106.0 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,22MAR@1653|Corynebacteriaceae 201174|Actinobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_353675_1 1122201.AUAZ01000021_gene3149 3.03e-16 83.6 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_29643_5 1283340.Q6WHK7_BPKVM 1.06e-19 83.6 4QAVS@10239|Viruses,4QX2I@35237|dsDNA viruses no RNA stage,4QR41@28883|Caudovirales,4QIEF@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF2829) - - - - - - - - - - - - - k59_29643_6 1567013.A0A0A7S0A9_9CAUD 9.92e-20 88.6 4QSW4@28883|Caudovirales,4QN03@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_299137_1 460265.Mnod_4078 2.4e-82 261.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria,1JZ7Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_299137_2 460265.Mnod_4285 3.68e-15 83.2 COG4695@1|root,COG5295@1|root,COG4695@2|Bacteria,COG5295@2|Bacteria,1R0FP@1224|Proteobacteria,2TYQP@28211|Alphaproteobacteria,1JY1H@119045|Methylobacteriaceae 1224|Proteobacteria UW PFAM Collagen triple helix repeat - - - - - - - - - - - - Collagen k59_299137_3 1449126.JQKL01000051_gene3168 7.44e-28 110.0 2CK39@1|root,32SBG@2|Bacteria,1V8KG@1239|Firmicutes,249UQ@186801|Clostridia 186801|Clostridia S Phage gp6-like head-tail connector protein - - - - - - - - - - - - Phage_connect_1 k59_299137_5 33898.JRHJ01000069_gene7355 3.48e-07 57.0 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 k59_70880_2 1084719.G3MBS8_9CAUD 5.99e-07 54.7 4QAR8@10239|Viruses,4QQ7Q@28883|Caudovirales,4QHZE@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_C92 - - - - - - - - - - - - - k59_2498_6 1232447.BAHW02000034_gene2521 1.51e-05 50.8 COG1925@1|root,COG1925@2|Bacteria,1VHJ4@1239|Firmicutes,24RNG@186801|Clostridia 186801|Clostridia G phosphoenolpyruvate-dependent sugar phosphotransferase system - - - - - - - - - - - - - k59_366707_1 1094561.MEI_00925 1.15e-12 68.2 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2U7X4@28211|Alphaproteobacteria,48TF4@772|Bartonellaceae 28211|Alphaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_191146_1 925775.XVE_2853 2.81e-31 116.0 COG4974@1|root,COG4974@2|Bacteria,1R1YU@1224|Proteobacteria,1T5DC@1236|Gammaproteobacteria,1XDBX@135614|Xanthomonadales 2|Bacteria L PFAM Phage integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_313707_1 105154.Q9MBU6_9VIRU 1.75e-39 145.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_313707_3 1385658.U5KNR1_9VIRU 3.18e-72 233.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_313707_6 1986029.Q9MBM6_9VIRU 1.61e-21 91.3 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_313707_7 145579.H_BPPHM 1.17e-10 65.5 4QCA6@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_313707_8 105154.Q9MBU6_9VIRU 8.17e-170 494.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_420492_2 1385658.U5KQQ9_9VIRU 0.00016 49.7 4QUMI@29258|ssDNA viruses,4QP4E@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_231308_1 1046714.AMRX01000006_gene3194 2.27e-35 140.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria,46B6N@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_299356_1 197221.22294879 2.07e-38 138.0 COG1351@1|root,COG1351@2|Bacteria,1GDYD@1117|Cyanobacteria 1117|Cyanobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - - - - - - - - - - Thy1 k59_124693_23 269482.Bcep1808_3224 1.79e-26 105.0 2C095@1|root,32VKM@2|Bacteria,1N0Y9@1224|Proteobacteria,2VUZF@28216|Betaproteobacteria,1KEDA@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1833) - - - - - - - - - - - - DUF1833 k59_124693_24 1168059.KB899087_gene1190 5.41e-21 89.4 COG0791@1|root,COG0791@2|Bacteria,1PUZR@1224|Proteobacteria,2UHBS@28211|Alphaproteobacteria 28211|Alphaproteobacteria M NLP P60 protein - - - - - - - - - - - - - k59_124693_25 556269.ACDQ01000003_gene1356 2.8e-91 326.0 COG4733@1|root,COG4733@2|Bacteria,1PG9M@1224|Proteobacteria,2W1MG@28216|Betaproteobacteria,4782D@75682|Oxalobacteraceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_124693_30 1123399.AQVE01000013_gene296 6.66e-21 107.0 COG1028@1|root,COG3405@1|root,COG1028@2|Bacteria,COG3405@2|Bacteria,1MWC8@1224|Proteobacteria,1S1X8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - CBM9_1 k59_124693_35 767434.Fraau_1253 7.57e-42 143.0 COG2131@1|root,COG2131@2|Bacteria,1NC75@1224|Proteobacteria,1T01U@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Deoxycytidylate deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_124693_39 1235798.C817_04114 2.22e-93 298.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia 186801|Clostridia L snf2 family - - - - - - - - - - - - SNF2_N k59_124693_41 439235.Dalk_4583 6.14e-14 69.7 2EI48@1|root,33BVK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_124693_42 1415147.V5Q8Y6_9CAUD 6.12e-81 278.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_124693_44 1150469.RSPPHO_02396 4.59e-57 193.0 COG1793@1|root,COG1793@2|Bacteria 2|Bacteria L dna ligase lig GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_124693_47 749222.Nitsa_1810 6.49e-68 213.0 2C2E9@1|root,32RAA@2|Bacteria,1RF5M@1224|Proteobacteria,433I8@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_124693_49 1261131.lam_653 2.04e-07 61.6 COG2887@1|root,COG2887@2|Bacteria,1QEBA@1224|Proteobacteria,2UANR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_165609_2 1211640.K4K5Z9_9CAUD 5.24e-05 45.4 4QF35@10239|Viruses,4QPS1@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_165981_6 753085.F4YCR7_9CAUD 5.56e-32 127.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_31704_4 525903.Taci_0493 8.77e-05 49.3 COG0454@1|root,COG0456@2|Bacteria,3TBQ2@508458|Synergistetes 508458|Synergistetes K PFAM Acetyltransferase (GNAT) family - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 k59_260806_1 118173.KB235914_gene3829 1.91e-25 109.0 2DBP2@1|root,2ZA71@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_355993_2 714943.Mucpa_0360 2.19e-10 62.4 COG3935@1|root,COG3935@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4373,DnaB_2,Phg_2220_C k59_73199_2 1168547.L7P648_9CIRC 1.24e-05 53.5 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_88085_1 1033991.RLEG12_18560 3.81e-17 83.6 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_33735_1 388051.AUFE01000035_gene4020 7.15e-45 159.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_33735_3 1038860.AXAP01000015_gene2006 1.47e-59 207.0 COG4695@1|root,COG4695@2|Bacteria,1N4JK@1224|Proteobacteria,2U6BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_portal k59_274918_1 1283284.AZUK01000001_gene2659 2.13e-35 138.0 COG1783@1|root,COG4373@1|root,COG1783@2|Bacteria,COG4373@2|Bacteria,1R6J1@1224|Proteobacteria,1RS5V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phage Terminase large subunit - - - ko:K06909 - - - - ko00000 - - - - k59_210058_1 439235.Dalk_4582 8.35e-21 89.7 28ZAD@1|root,2ZM28@2|Bacteria,1P51R@1224|Proteobacteria,4335R@68525|delta/epsilon subdivisions,2WXAI@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_219861_1 489825.LYNGBM3L_53240 5.03e-40 138.0 2AQQ1@1|root,31FXK@2|Bacteria,1G7GC@1117|Cyanobacteria,1HBNM@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_219861_2 497965.Cyan7822_0952 4.15e-52 187.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G15Q@1117|Cyanobacteria 1117|Cyanobacteria T tpr repeat - - - - - - - - - - - - CHAT,TPR_10 k59_88091_1 545697.HMPREF0216_02824 2.16e-06 48.1 2C2JW@1|root,3316C@2|Bacteria,1VFRB@1239|Firmicutes,24R0E@186801|Clostridia,36PKF@31979|Clostridiaceae 186801|Clostridia S Domain of Unknown Function (DUF1599) - - - - - - - - - - - - DUF1599 k59_423322_1 937777.Deipe_0478 3.01e-44 155.0 28W6R@1|root,2ZI7D@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_382356_1 1618247.A0A0C5IMK7_9CIRC 5.96e-12 71.6 4QEEA@10239|Viruses,4QUMF@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_249179_1 1051675.G0YQF5_9CAUD 6.01e-37 143.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_20004_1 1165094.RINTHH_3920 2.7e-23 97.4 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_6049_1 349106.PsycPRwf_1339 6.22e-07 52.4 COG1974@1|root,COG1974@2|Bacteria,1RIY3@1224|Proteobacteria,1S2IC@1236|Gammaproteobacteria,3NN9Q@468|Moraxellaceae 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins prpA - - - - - - - - - - - HTH_3,Peptidase_S24 k59_6052_1 1379695.S5TNA9_9CIRC 5.11e-72 231.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_210394_1 667121.ET1_11_00530 3.74e-09 56.2 COG0607@1|root,COG0607@2|Bacteria,1RHVM@1224|Proteobacteria,1SD9C@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0607 Rhodanese-related sulfurtransferase pspE GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K03972 - - - - ko00000 - - iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779 Rhodanese k59_318843_2 153496.JNAB01000064_gene1756 7.97e-26 102.0 2DN9H@1|root,32W8X@2|Bacteria,1QU08@1224|Proteobacteria,2TWV2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DNA N-6-adenine-methyltransferase (Dam) - - - - - - - - - - - - Dam k59_101226_3 1165094.RINTHH_3920 8.04e-74 236.0 2EVUA@1|root,33P81@2|Bacteria 2|Bacteria - - CP_0543 - - - - - - - - - - - - k59_101226_7 1385658.U5KPZ6_9VIRU 1.92e-165 483.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_303099_1 991905.SL003B_1702 1.8e-06 55.8 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_88345_1 1692242.A0A0K1RL37_9CIRC 6.61e-16 83.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_181763_1 1504822.CCNO01000015_gene594 8.64e-114 357.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_384004_1 1795983.A0A140CTJ3_9CIRC 2.15e-13 76.6 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_169811_1 876269.ARWA01000001_gene993 1.02e-25 109.0 COG1216@1|root,COG1216@2|Bacteria,1R554@1224|Proteobacteria,2U3P6@28211|Alphaproteobacteria,3N9XF@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Glycosyl transferase, family 2 MA20_08330 - - - - - - - - - - - Glyco_tranf_2_3 k59_129217_1 1381123.AYOD01000035_gene3597 1.9e-06 53.1 COG3941@1|root,COG3941@2|Bacteria,1QVE0@1224|Proteobacteria,2TWCY@28211|Alphaproteobacteria,43RR6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S tape measure - - - - - - - - - - - - - k59_103396_1 444876.E3SQN9_9CAUD 1.74e-17 87.4 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0039638,GO:0044403,GO:0044406,GO:0044419,GO:0044423,GO:0044650,GO:0051704,GO:0098015,GO:0098024 - - - - - - - - - - - k59_115833_1 691965.D4P7E5_9CAUD 3.35e-25 99.4 4QEVD@10239|Viruses,4QW84@35237|dsDNA viruses no RNA stage,4QQSX@28883|Caudovirales,4QMU4@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_115833_2 691965.D4P7E6_9CAUD 9.07e-32 126.0 4QAK6@10239|Viruses,4R01K@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_277412_1 1537917.JU82_03700 1.79e-61 200.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII,SNF2_N k59_277412_2 428125.CLOLEP_01377 7.25e-32 118.0 2E0G5@1|root,32W28@2|Bacteria,1VAS0@1239|Firmicutes,24NYA@186801|Clostridia,3WNKT@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_196868_5 443254.Marpi_0310 1.66e-07 54.3 COG4570@1|root,COG4570@2|Bacteria 2|Bacteria L crossover junction endodeoxyribonuclease activity rusA - 3.1.22.4 ko:K01160 - - - - ko00000,ko01000,ko03400 - - - RusA k59_79671_1 749222.Nitsa_1810 6.61e-42 144.0 2C2E9@1|root,32RAA@2|Bacteria,1RF5M@1224|Proteobacteria,433I8@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_305710_3 926560.KE387023_gene1188 2.02e-15 78.6 COG4675@1|root,COG4675@2|Bacteria,1WMKD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_277417_1 691965.D4P7I3_9CAUD 3.65e-126 395.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_103412_1 1121286.AUMT01000001_gene29 4.22e-64 207.0 2C7AW@1|root,32WDQ@2|Bacteria,4NSS0@976|Bacteroidetes,1I4J8@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_361703_1 1458848.X2KS26_9CAUD 1.69e-09 64.3 4QBMV@10239|Viruses,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_10421_3 1444310.JANV01000162_gene1177 3.36e-18 81.3 2EC8I@1|root,33670@2|Bacteria,1VENI@1239|Firmicutes,4HR98@91061|Bacilli,1ZJCG@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_172493_1 596152.DesU5LDRAFT_0548 1.54e-34 134.0 COG1783@1|root,COG1783@2|Bacteria,1MVJB@1224|Proteobacteria,42YU8@68525|delta/epsilon subdivisions,2WUCP@28221|Deltaproteobacteria,2M8PF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_427580_1 742733.HMPREF9469_05033 8.94e-101 308.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,222GA@1506553|Lachnoclostridium 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_172494_1 1216932.CM240_0536 1.04e-43 163.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,36DG2@31979|Clostridiaceae 186801|Clostridia NU type II secretion system protein E xcpR - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_350479_1 1535422.ND16A_0167 3.27e-12 70.1 COG1403@1|root,COG1403@2|Bacteria,1NE62@1224|Proteobacteria,1S9QW@1236|Gammaproteobacteria 1236|Gammaproteobacteria V HNH nucleases - - - - - - - - - - - - HNH k59_308347_1 691965.D4P7I3_9CAUD 5.04e-115 369.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_401205_1 1465751.W8QF12_9VIRU 1.11e-259 748.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA polymerase family B - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004527,GO:0004540,GO:0005575,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0018995,GO:0019058,GO:0019079,GO:0019438,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0042025,GO:0042221,GO:0043170,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0050896,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902074 - - - - - - - - - - - k59_268238_1 1410653.JHVC01000013_gene3686 2.76e-79 266.0 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,248DP@186801|Clostridia,36GN9@31979|Clostridiaceae 186801|Clostridia S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_185838_2 764299.STRIC_2124 1.15e-20 91.3 2DR9Y@1|root,33AUY@2|Bacteria,1VEP1@1239|Firmicutes,4HP3X@91061|Bacilli 91061|Bacilli L NUMOD4 motif - - - - - - - - - - - - HNH_3,NUMOD4 k59_377363_1 1121871.AUAT01000022_gene1837 8.59e-12 69.7 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli 91061|Bacilli L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_388189_1 1224164.B843_01055 0.00028 53.5 COG0419@1|root,COG0791@1|root,COG3953@1|root,COG5412@1|root,COG0419@2|Bacteria,COG0791@2|Bacteria,COG3953@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,22N4W@1653|Corynebacteriaceae 201174|Actinobacteria M Tail protein - - - - - - - - - - - - - k59_228808_1 553217.ENHAE0001_2198 1.8e-21 98.2 COG4643@1|root,COG5519@1|root,COG4643@2|Bacteria,COG5519@2|Bacteria,1QU3K@1224|Proteobacteria 1224|Proteobacteria L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - DUF3987,Prim-Pol k59_389576_1 1385658.U5KNR1_9VIRU 1.36e-36 135.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_228846_1 691965.D4P7C5_9CAUD 5.72e-05 44.3 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_228846_3 742740.HMPREF9474_02271 4.9e-154 449.0 28J3N@1|root,2Z8ZU@2|Bacteria,1V15Z@1239|Firmicutes,249Z0@186801|Clostridia,221RR@1506553|Lachnoclostridium 186801|Clostridia S Phage portal protein - - - - - - - - - - - - Phage_portal k59_241453_1 428125.CLOLEP_01375 3.55e-68 238.0 2EWZQ@1|root,33QB0@2|Bacteria,1V0T1@1239|Firmicutes,249Z2@186801|Clostridia,3WNBH@541000|Ruminococcaceae 186801|Clostridia S DNA polymerase type-B family - - - - - - - - - - - - - k59_228888_1 1499967.BAYZ01000085_gene5186 1.08e-51 176.0 COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria 2|Bacteria GM NAD(P)H-binding wbmF - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_241484_1 1121430.JMLG01000008_gene1514 2.19e-07 55.5 COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,262WF@186807|Peptococcaceae 186801|Clostridia K Represses a number of genes involved in the response to DNA damage (SOS response) - - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - HTH_19,HTH_3,HTH_31,Peptidase_S24 k59_430929_1 1692255.A0A0K1RL52_9CIRC 5.22e-91 281.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_241492_2 645099.MREP_BBTVA 3.91e-08 57.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_14688_2 1692242.A0A0K1RKZ2_9CIRC 4.76e-43 155.0 4QFEW@10239|Viruses,4QUKZ@29258|ssDNA viruses 10239|Viruses - - - - - - - - - - - - - - - k59_216897_2 1380394.JADL01000006_gene5249 6.27e-72 245.0 28QU5@1|root,2ZD9H@2|Bacteria,1RAU8@1224|Proteobacteria,2VC6Q@28211|Alphaproteobacteria,2JY0A@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_216897_5 1504672.669782902 3.46e-16 81.6 29F88@1|root,3025X@2|Bacteria,1NBJS@1224|Proteobacteria,2VWHK@28216|Betaproteobacteria,4AIW2@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_216897_6 156889.Mmc1_1716 2.49e-51 177.0 28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,2U1P7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1200_2 525246.HMPREF0058_1676 7.94e-29 114.0 COG2887@1|root,COG2887@2|Bacteria,2IBBB@201174|Actinobacteria,4D5D6@85005|Actinomycetales 201174|Actinobacteria L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_244272_3 365046.Rta_33080 9.03e-16 80.5 COG3405@1|root,COG3405@2|Bacteria,1QZE5@1224|Proteobacteria,2W62R@28216|Betaproteobacteria,4AIQV@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - k59_271032_2 693986.MOC_5365 0.000927 42.7 COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria,2UGF3@28211|Alphaproteobacteria,1JWTP@119045|Methylobacteriaceae 28211|Alphaproteobacteria K Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - HTH_3 k59_392543_1 382464.ABSI01000016_gene633 8.66e-10 69.3 COG0749@1|root,COG0749@2|Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA_2 - 2.7.7.7 ko:K02334,ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A k59_1213_1 520709.F985_01890 1e-54 183.0 COG0270@1|root,COG0270@2|Bacteria,1N0XD@1224|Proteobacteria,1T05A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_55975_1 691965.D4P7L7_9CAUD 2.22e-76 257.0 4QB9J@10239|Viruses,4QXFE@35237|dsDNA viruses no RNA stage,4QS1Z@28883|Caudovirales,4QN8F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_55975_2 742733.HMPREF9469_05040 4.12e-67 210.0 29YRZ@1|root,30KMY@2|Bacteria,1V4Y4@1239|Firmicutes,24HPY@186801|Clostridia,221XY@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_55975_3 742740.HMPREF9474_02280 7.65e-30 109.0 2CGGB@1|root,32UNH@2|Bacteria,1VD9W@1239|Firmicutes,24MWC@186801|Clostridia,2235P@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - k59_164348_1 1504672.669787408 7.08e-73 248.0 COG0553@1|root,COG1040@1|root,COG2263@1|root,COG0553@2|Bacteria,COG1040@2|Bacteria,COG2263@2|Bacteria,1MXQH@1224|Proteobacteria,2WHJ7@28216|Betaproteobacteria 28216|Betaproteobacteria KL methylase - - - - - - - - - - - - - k59_314209_1 925775.XVE_4124 1.98e-26 102.0 COG4974@1|root,COG4974@2|Bacteria,1R1YU@1224|Proteobacteria,1T5DC@1236|Gammaproteobacteria,1XDBX@135614|Xanthomonadales 2|Bacteria L PFAM Phage integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_71325_2 1114179.I2FLP7_9CAUD 4.96e-08 55.8 4QFN8@10239|Viruses,4QYWE@35237|dsDNA viruses no RNA stage,4QS52@28883|Caudovirales,4QP1K@10744|Podoviridae 10744|Podoviridae S metal ion binding - - - - - - - - - - - - - k59_407565_1 1231057.AMGD01000018_gene3607 2.7e-09 62.0 2EYE8@1|root,33RNB@2|Bacteria,1VQZW@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_43204_2 484770.UFO1_2472 2.09e-21 88.2 28P3F@1|root,32U60@2|Bacteria,1VDW0@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_43204_5 445970.ALIPUT_00696 2.87e-24 119.0 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria,4NF3E@976|Bacteroidetes,2FNYJ@200643|Bacteroidia 976|Bacteroidetes D Psort location OuterMembrane, score - - - - - - - - - - - - - k59_191409_1 742740.HMPREF9474_02251 5e-20 84.0 2EK5K@1|root,33DW0@2|Bacteria,1UU54@1239|Firmicutes,255II@186801|Clostridia 186801|Clostridia S Putative phage holin Dp-1 - - - - - - - - - - - - Phage_holin_Dp1 k59_71326_1 29875.EHK22908 1.3e-05 58.2 2CNC5@1|root,2QV54@2759|Eukaryota,39S8X@33154|Opisthokonta,3NZKK@4751|Fungi,3QRQ4@4890|Ascomycota,214Z4@147550|Sordariomycetes,3TUCQ@5125|Hypocreales 4751|Fungi O Pectate lyase superfamily protein - - 3.2.1.58 ko:K01210 ko00500,map00500 - R00308,R03115 RC00467 ko00000,ko00001,ko01000 - - - Pectate_lyase_3 k59_205766_1 1408324.JNJK01000026_gene919 6.04e-17 89.4 COG2189@1|root,COG2189@2|Bacteria,1UHUQ@1239|Firmicutes,25E35@186801|Clostridia,27KYN@186928|unclassified Lachnospiraceae 186801|Clostridia L DNA methylase - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_30231_1 28229.ND2E_3441 1.9e-30 121.0 COG1196@1|root,COG1196@2|Bacteria,1NK8W@1224|Proteobacteria,1SGJD@1236|Gammaproteobacteria 1236|Gammaproteobacteria D DNA N-6-adenine-methyltransferase (Dam) - - - - - - - - - - - - Dam k59_31862_1 1121406.JAEX01000030_gene1992 1.02e-07 52.0 2BI7R@1|root,32CD0@2|Bacteria,1NJBE@1224|Proteobacteria,431S8@68525|delta/epsilon subdivisions,2WWFQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_247387_1 1123400.KB904746_gene1154 6.96e-130 399.0 COG0208@1|root,COG1372@1|root,COG0208@2|Bacteria,COG1372@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,45ZQV@72273|Thiotrichales 72273|Thiotrichales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526,ko:K03676 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03110,ko03400 - - - Glutaredoxin,Ribonuc_red_sm k59_381184_1 292459.STH692 2.62e-59 196.0 COG0812@1|root,COG0812@2|Bacteria,1UY20@1239|Firmicutes,251G3@186801|Clostridia 186801|Clostridia M UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain - - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_208183_1 697281.Mahau_2914 8.27e-44 161.0 COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,42FVH@68295|Thermoanaerobacterales 186801|Clostridia S TIGRFAM phage portal protein, HK97 family - - - - - - - - - - - - Phage_Mu_F,Phage_portal k59_273758_2 748224.HMPREF9436_00407 2.92e-17 79.7 COG3108@1|root,COG3108@2|Bacteria,1VFRJ@1239|Firmicutes,24R9N@186801|Clostridia 186801|Clostridia M Peptidase M15A - - 3.4.17.14 ko:K08640 - - - - ko00000,ko01000,ko01002,ko01011 - - - PG_binding_1,Peptidase_M15_3 k59_273758_7 1120963.KB894514_gene389 3.37e-57 206.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,1S4YH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_86499_1 1166948.JPZL01000002_gene1842 1.65e-18 91.3 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_261342_2 873517.HMPREF1977_1589 1.08e-05 49.7 COG3023@1|root,COG3023@2|Bacteria,4NRQX@976|Bacteroidetes,1IJ39@117743|Flavobacteriia,1ERVD@1016|Capnocytophaga 976|Bacteroidetes V N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_180152_2 1244856.K4PY83_9CAUD 2.55e-14 72.8 4QE7X@10239|Viruses,4QVF0@35237|dsDNA viruses no RNA stage,4QPUM@28883|Caudovirales,4QP17@10744|Podoviridae 10744|Podoviridae S Cytidine and deoxycytidylate deaminase zinc-binding region - - - - - - - - - - - - - k59_18215_1 1166018.FAES_3935 5.59e-10 68.9 COG1783@1|root,COG5410@1|root,COG1783@2|Bacteria,COG5410@2|Bacteria,4NN30@976|Bacteroidetes,47YRR@768503|Cytophagia 976|Bacteroidetes S Phage terminase large subunit - - - - - - - - - - - - Terminase_6 k59_343305_1 1111454.HMPREF1250_1802 1.58e-28 111.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,4H331@909932|Negativicutes 909932|Negativicutes D Sporulation initiation inhibitor protein Soj soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_6328_1 105154.Q9MBU6_9VIRU 3.31e-122 367.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_220240_3 1437610.BREU_1253 3.09e-29 119.0 COG3740@1|root,COG3740@2|Bacteria,2HBPZ@201174|Actinobacteria,4CZX1@85004|Bifidobacteriales 201174|Actinobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_275485_1 759914.BP951000_2300 3.3e-09 64.3 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes 203691|Spirochaetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_319196_1 1609634.A0A0C5AFV4_9VIRU 2.75e-56 192.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_289259_1 105154.Q9MBU6_9VIRU 2.31e-80 255.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_359181_1 1072685.IX83_07120 1.08e-47 170.0 COG0507@1|root,COG5362@1|root,COG0507@2|Bacteria,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2W8BI@28216|Betaproteobacteria,3T6FT@506|Alcaligenaceae 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_76816_1 196162.Noca_4057 2.06e-92 306.0 COG3391@1|root,COG3391@2|Bacteria,2I4QK@201174|Actinobacteria 201174|Actinobacteria L amine dehydrogenase activity - - - - - - - - - - - - - k59_345519_7 1122226.AUHX01000007_gene2631 1.36e-38 132.0 COG0629@1|root,COG0629@2|Bacteria,4NT9M@976|Bacteroidetes,1I1XK@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF3127) - - - - - - - - - - - - DUF3127 k59_60725_1 641524.ADICYQ_4183 0.000545 48.1 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - Beta_helix,CHU_C,IgGFc_binding,Laminin_G_3,Malectin,PKD k59_168524_1 1548151.LS70_04095 7.63e-06 54.3 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_183426_1 1123276.KB893279_gene2211 2.87e-16 82.0 2C9JF@1|root,32RPD@2|Bacteria 2|Bacteria S Erf family - - - - - - - - - - - - ERF k59_183426_2 1231190.NA8A_04270 9.46e-07 53.5 2CF2U@1|root,32YEW@2|Bacteria,1NA2K@1224|Proteobacteria,2UITY@28211|Alphaproteobacteria,43PQ2@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_361447_1 216596.RL3938 3.86e-43 157.0 COG4626@1|root,COG4626@2|Bacteria,1R2FH@1224|Proteobacteria,2UCW2@28211|Alphaproteobacteria,4BCYA@82115|Rhizobiaceae 28211|Alphaproteobacteria S Terminase - - - - - - - - - - - - - k59_79440_1 1173709.M3VMK9_9CIRC 2.65e-49 167.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_347551_1 1121866.AUGK01000014_gene2070 0.000449 45.1 28HHC@1|root,2Z7T2@2|Bacteria 2|Bacteria S AAA domain - - - - - - - - - - - - AAA_24 k59_413360_1 1121447.JONL01000012_gene3400 1.4e-11 66.6 2E0BM@1|root,32VYT@2|Bacteria,1N8GG@1224|Proteobacteria 1224|Proteobacteria S T5orf172 - - - - - - - - - - - - T5orf172 k59_221568_1 294631.Q5ZGE2_9CAUD 2.4e-27 106.0 4QB0R@10239|Viruses,4QZQF@35237|dsDNA viruses no RNA stage,4QR5Y@28883|Caudovirales,4QN4Q@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_221568_2 1327981.S0A0T8_9CAUD 9.51e-34 122.0 4QAVQ@10239|Viruses,4QXUP@35237|dsDNA viruses no RNA stage,4QPGB@28883|Caudovirales,4QKPR@10699|Siphoviridae 10699|Siphoviridae S Phage major tail protein 2 - - - - - - - - - - - - - k59_221568_6 294631.Q5ZGD4_9CAUD 1.3e-95 316.0 4QB2X@10239|Viruses,4QXYM@35237|dsDNA viruses no RNA stage,4QRYM@28883|Caudovirales,4QMB2@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_103229_1 994573.T472_0212665 1.79e-117 348.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_372131_1 1692252.A0A0K1RL35_9CIRC 9.02e-21 99.8 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_147367_2 743721.Psesu_1138 1.11e-06 51.6 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding MA20_07360 - - ko:K07075,ko:K15546 - - - - ko00000,ko03000 - - - HTH_3,HTH_31,NTP_transf_2,Peptidase_S24,SKI k59_169886_3 1120963.KB894509_gene2068 1.4e-11 71.6 2DPZ6@1|root,3341A@2|Bacteria,1R2F6@1224|Proteobacteria,1T5PJ@1236|Gammaproteobacteria 2|Bacteria - - - - - - - - - - - - - - - k59_24511_1 1121938.AUDY01000014_gene3437 2.61e-15 79.7 COG4974@1|root,COG4974@2|Bacteria,1UXH8@1239|Firmicutes,4HHM9@91061|Bacilli,3NG3V@45667|Halobacillus 91061|Bacilli L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_integrase k59_333293_2 742918.D4N3P2_9CIRC 3.83e-22 97.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_253336_1 1401067.HMPREF0872_06850 3.77e-32 127.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H2W4@909932|Negativicutes 909932|Negativicutes L SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_308107_1 153721.MYP_567 0.000111 55.5 COG3291@1|root,COG4099@1|root,COG5295@1|root,COG5297@1|root,COG3291@2|Bacteria,COG4099@2|Bacteria,COG5295@2|Bacteria,COG5297@2|Bacteria,4NF6Q@976|Bacteroidetes,47KN7@768503|Cytophagia 976|Bacteroidetes GUW candidate b-glycosidase, glycoside hydrolase family 8 protein - - - - - - - - - - - - Beta_helix,Big_3_3,M60-like_N,NosD,Peptidase_M60 k59_350596_1 883077.HMPREF9241_00154 8.01e-90 286.0 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,4D420@85005|Actinomycetales 201174|Actinobacteria KL SNF2 family N-terminal domain protein - - - - - - - - - - - - SNF2_N k59_199689_1 1122211.JMLW01000023_gene1088 1.26e-08 59.3 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1XK3A@135619|Oceanospirillales 135619|Oceanospirillales C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_10527_1 297246.lpp2117 9.3e-25 105.0 COG0305@1|root,COG0305@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria,1JDPV@118969|Legionellales 118969|Legionellales L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,Toprim_2 k59_10527_2 1123489.AUAN01000002_gene950 3.29e-15 76.3 COG3935@1|root,COG3935@2|Bacteria,1VHH7@1239|Firmicutes,4H5YT@909932|Negativicutes 909932|Negativicutes L DnaD domain protein - - - - - - - - - - - - - k59_268049_2 556268.OFAG_02256 3.59e-41 141.0 2A24E@1|root,30QER@2|Bacteria,1NZ1I@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_333456_1 1439940.BAY1663_02317 1.87e-22 95.9 28PTC@1|root,2ZCEM@2|Bacteria,1RBV9@1224|Proteobacteria,1S2ZQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type VI secretion system VasI, EvfG, VC_A0118 - - - ko:K11909 - - - - ko00000,ko02044 3.A.23.1 - - VasI k59_93148_1 28358.Q3V5F4_9CAUD 1.42e-06 52.8 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_237669_1 654929.REP_PCV1C 3.67e-27 109.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_51400_2 1416760.AYMS01000142_gene624 6.42e-222 629.0 COG1783@1|root,COG1783@2|Bacteria,4NSZ4@976|Bacteroidetes 976|Bacteroidetes S phage Terminase large subunit - - - - - - - - - - - - - k59_239393_1 768066.HELO_2645 2.6e-52 187.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_67259_2 444878.E3SQZ4_9CAUD 1.27e-06 56.6 4QASW@10239|Viruses,4QVP9@35237|dsDNA viruses no RNA stage,4QRA5@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_239402_3 1151292.QEW_4407 2.43e-05 47.4 COG1475@1|root,COG1475@2|Bacteria,1TR7E@1239|Firmicutes,24AXU@186801|Clostridia 186801|Clostridia K ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_430171_1 1406780.U5PWM1_9CAUD 3.37e-30 117.0 4QDXM@10239|Viruses,4QWIX@35237|dsDNA viruses no RNA stage,4QQF6@28883|Caudovirales,4QNXH@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_107895_4 1273103.NM10_06751 1.88e-09 64.3 COG0741@1|root,COG3064@1|root,COG3941@1|root,COG0741@2|Bacteria,COG3064@2|Bacteria,COG3941@2|Bacteria,1V33U@1239|Firmicutes,4H401@909932|Negativicutes 909932|Negativicutes L tape measure - - - - - - - - - - - - SLT k59_120425_1 1049564.TevJSym_au00620 0.00017 45.1 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1J4VY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0568 DNA-directed RNA polymerase, sigma subunit rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_13439_1 358220.C380_12140 5.18e-58 199.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2VNHP@28216|Betaproteobacteria,4AC68@80864|Comamonadaceae 28216|Betaproteobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_430195_1 1035193.HMPREF9073_00671 3.04e-21 90.1 COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1HZJ2@117743|Flavobacteriia 976|Bacteroidetes O prohibitin homologues - - - - - - - - - - - - Band_7 k59_387521_5 1316936.K678_00215 6.28e-14 84.7 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_282558_2 936136.ARRT01000003_gene6234 1.69e-12 72.8 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria,4BA1A@82115|Rhizobiaceae 28211|Alphaproteobacteria GM Polysaccharide biosynthesis protein lpsB2 GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192 - ko:K13013 - - - - ko00000,ko01005 - - - CoA_binding_3,Polysacc_synt_2 k59_239436_2 1282664.H354_06646 1.09e-20 85.5 2EC8I@1|root,33670@2|Bacteria,1VENI@1239|Firmicutes,4HR98@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_388035_4 279383.Q5DN86_9CAUD 6.48e-60 202.0 4QG7K@10239|Viruses,4QZQI@35237|dsDNA viruses no RNA stage,4QQZP@28883|Caudovirales,4QN68@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_388035_5 462590.A9J512_BPPYU 2.25e-24 101.0 4QG7K@10239|Viruses,4QZQI@35237|dsDNA viruses no RNA stage,4QQZP@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_404132_1 428127.EUBDOL_01214 9.37e-12 74.7 COG3883@1|root,COG5283@1|root,COG3883@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes 1239|Firmicutes D Phage tail tape measure protein, TP901 family - - - - - - - - - - - - LysM,PhageMin_Tail k59_121221_1 1235790.C805_00844 3.36e-35 127.0 2E2AR@1|root,32XG5@2|Bacteria,1VC42@1239|Firmicutes,25DRJ@186801|Clostridia 186801|Clostridia S AP2 domain - - - - - - - - - - - - AP2,HNH_3 k59_430563_1 1788452.A0A190WHG0_9CIRC 7.51e-23 99.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_430563_3 1379725.S5TMY9_9CIRC 9.09e-12 68.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_239973_1 406818.XBJ1_0423 1.12e-14 69.7 2EPJJ@1|root,33H66@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_162900_1 289376.THEYE_A1193 5.57e-12 63.9 COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae 40117|Nitrospirae O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_162900_3 1121406.JAEX01000001_gene340 3.29e-56 183.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2M9TD@213115|Desulfovibrionales 28221|Deltaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_203804_1 351016.RAZWK3B_17388 1.55e-40 138.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2P3SI@2433|Roseobacter 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_203804_2 411684.HPDFL43_00027750 1.25e-175 491.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,43IUV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_324858_2 691965.D4P7B9_9CAUD 2.47e-28 105.0 4QFDH@10239|Viruses,4QWV5@35237|dsDNA viruses no RNA stage,4QPB8@28883|Caudovirales,4QKNN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_257245_1 616991.JPOO01000003_gene1095 6.1e-06 47.0 28VED@1|root,2ZHGY@2|Bacteria,4P9CG@976|Bacteroidetes,1IFQM@117743|Flavobacteriia,23IGE@178469|Arenibacter 616991.JPOO01000003_gene1095|- - - - - - - - - - - - - - - - k59_216713_2 497964.CfE428DRAFT_0207 6.74e-40 144.0 COG0859@1|root,COG0859@2|Bacteria,46TJT@74201|Verrucomicrobia 74201|Verrucomicrobia M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9,Mannosyl_trans3 k59_149432_3 644968.DFW101_3487 1.41e-12 73.9 2AG31@1|root,3167H@2|Bacteria,1NGCE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_14373_2 1250005.PHEL85_1075 2.47e-15 90.1 COG1345@1|root,COG2706@1|root,COG1345@2|Bacteria,COG2706@2|Bacteria 2|Bacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - DUF3494,Lactonase,Laminin_G_3,Peptidase_S9 k59_82029_3 1385658.U5KPZ6_9VIRU 3.13e-192 556.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_176195_1 1122201.AUAZ01000017_gene2960 1.76e-145 426.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_338409_1 105154.Q9MBU2_9VIRU 2.58e-22 93.2 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_338409_3 1986029.Q9MBM3_9VIRU 1.1e-68 223.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_338409_5 105154.Q9MBU6_9VIRU 1.11e-191 554.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_338409_6 105154.Q9MBU3_9VIRU 2.25e-10 65.5 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_392413_5 1115632.JAFW01000001_gene395 1.04e-57 204.0 2B654@1|root,31Z21@2|Bacteria,2H1K4@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_392413_7 67356.KL575597_gene7661 1.9e-09 65.5 COG0726@1|root,COG4409@1|root,COG0726@2|Bacteria,COG4409@2|Bacteria,2IC87@201174|Actinobacteria 201174|Actinobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_95661_1 1121930.AQXG01000006_gene890 2.09e-07 60.8 COG3941@1|root,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_270903_1 1475143.W8SNN0_9CIRC 1.06e-23 102.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_297902_1 1081644.IMCC13023_05740 1.18e-63 201.0 arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria,4FKKX@85023|Microbacteriaceae 2|Bacteria - - - - - - - - - - - - - - - k59_344025_1 768066.HELO_2115 9.26e-32 119.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria 1224|Proteobacteria KT HNH endonuclease - - - - - - - - - - - - HNH_3 k59_59489_1 1486472.A0A068F1U8_9CAUD 3.72e-152 440.0 4QATB@10239|Viruses,4QVUZ@35237|dsDNA viruses no RNA stage,4QPGA@28883|Caudovirales 28883|Caudovirales S Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - - k59_5020_1 1618248.A0A0C5IB82_9CIRC 7.4e-56 186.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_45584_1 1166016.W5S_1521 1.56e-41 151.0 COG0175@1|root,COG0175@2|Bacteria,1PZ96@1224|Proteobacteria,1SBUC@1236|Gammaproteobacteria,1MRAZ@122277|Pectobacterium 1236|Gammaproteobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_396012_1 1526927.Plano_2364 7.17e-08 55.1 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,26EKU@186818|Planococcaceae 91061|Bacilli O Belongs to the peptidase S8 family - - - ko:K13277 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8,SLH k59_396012_2 570417.WP0279 4.49e-14 70.5 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,47FDC@766|Rickettsiales 766|Rickettsiales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_87171_2 1158150.KB906241_gene1082 1.61e-07 57.8 COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,1RSQC@1236|Gammaproteobacteria,1WWSI@135613|Chromatiales 135613|Chromatiales L Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_45585_2 349163.Acry_0517 2.2e-30 119.0 28N1N@1|root,2ZB7Q@2|Bacteria,1R86T@1224|Proteobacteria,2U0A6@28211|Alphaproteobacteria,2JRMI@204441|Rhodospirillales 204441|Rhodospirillales H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_5331_1 742733.HMPREF9469_05020 0.00025 50.1 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia,221IX@1506553|Lachnoclostridium 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_59762_6 1429916.X566_15365 2.69e-15 72.8 2BZTS@1|root,33131@2|Bacteria,1NBBP@1224|Proteobacteria,2UIZA@28211|Alphaproteobacteria,3K1K3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_59762_10 536233.CLO_0532 1.29e-21 104.0 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,248E9@186801|Clostridia,36EE3@31979|Clostridiaceae 186801|Clostridia L Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_396316_1 1401297.U3PFP4_9CAUD 1.32e-05 54.3 4QBMV@10239|Viruses,4QUU6@35237|dsDNA viruses no RNA stage,4QQ7Y@28883|Caudovirales,4QNK5@10744|Podoviridae 10744|Podoviridae S DNA-directed RNA polymerase activity - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_113110_1 545695.TREAZ_0592 2.18e-46 161.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - Dam,PhageMin_Tail k59_142694_2 357804.Ping_1595 4.06e-44 158.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_33282_1 546264.NEIFLAOT_01370 4.88e-17 88.2 COG5281@1|root,COG5283@1|root,COG5281@2|Bacteria,COG5283@2|Bacteria,1NWJI@1224|Proteobacteria,2VKT1@28216|Betaproteobacteria 28216|Betaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_302334_1 1123392.AQWL01000014_gene812 2.25e-64 212.0 COG1793@1|root,COG1793@2|Bacteria,1MYI2@1224|Proteobacteria,2VTVD@28216|Betaproteobacteria 28216|Betaproteobacteria L DNA polymerase - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_primase_S k59_329750_1 1499689.CCNN01000007_gene2224 8.82e-12 69.3 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae 186801|Clostridia L snf2 family - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_360012_1 1041142.ATTP01000043_gene5284 1.24e-38 146.0 29WT6@1|root,30IEJ@2|Bacteria,1PEK3@1224|Proteobacteria,2V9RG@28211|Alphaproteobacteria,4BH2H@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_182483_1 935948.KE386495_gene2287 2.47e-11 73.2 COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,42FDS@68295|Thermoanaerobacterales 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A,DNA_pol_A_exo1 k59_155924_2 1234888.K0A2J2_9VIRU 2.08e-111 343.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_145105_1 478749.BRYFOR_08554 4.02e-42 150.0 COG0553@1|root,COG0553@2|Bacteria,1TS9W@1239|Firmicutes,24CGX@186801|Clostridia 186801|Clostridia KL Helicase conserved C-terminal domain - - - - - - - - - - - - - k59_77842_1 1618248.A0A0C5IB82_9CIRC 3.14e-84 262.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_61555_1 574375.BAGA_15775 1.35e-21 102.0 COG0270@1|root,COG0270@2|Bacteria,1TSNX@1239|Firmicutes,4HFAI@91061|Bacilli,1ZBQM@1386|Bacillus 91061|Bacilli L DNA (cytosine-5-)-methyltransferase activity dcm GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008168,GO:0009307,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032776,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044728,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0099046,GO:1901360 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase,N6_N4_Mtase k59_127989_1 105154.Q9MBU0_9VIRU 1.11e-63 210.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_102367_1 756280.M4PSN3_9CAUD 1.45e-09 62.8 4QFED@10239|Viruses,4R072@35237|dsDNA viruses no RNA stage,4QPEH@28883|Caudovirales 28883|Caudovirales S tRNA modification - - - - - - - - - - - - - k59_346632_1 266940.Krad_4383 2.22e-06 49.3 COG1738@1|root,COG1738@2|Bacteria,2IGCP@201174|Actinobacteria 201174|Actinobacteria S Putative vitamin uptake transporter - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_346632_2 1157634.KB912959_gene1709 3.64e-27 108.0 2EB9A@1|root,3359T@2|Bacteria,2INFV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_78281_1 1282362.AEAC466_04585 4.87e-74 232.0 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_304443_1 1537917.JU82_03700 3.19e-65 212.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII,SNF2_N k59_128016_1 1541887.A0A097P464_9CAUD 3.08e-22 99.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_128016_2 1408311.JNJM01000031_gene2485 4.07e-06 50.4 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,2PQVX@265975|Oribacterium 186801|Clostridia L DNA polymerase A domain - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_257097_1 765910.MARPU_05580 4.34e-61 202.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,1RZZ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3723 Recombinational DNA repair protein (RecE pathway) recT GO:0000724,GO:0000725,GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0018130,GO:0019438,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043150,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_216555_2 1548903.A0A0A1IWQ8_9CAUD 7.6e-59 197.0 4QAIK@10239|Viruses,4QPEB@28883|Caudovirales 28883|Caudovirales S phosphoprotein phosphatase activity - - - - - - - - - - - - - k59_725_1 172045.KS04_14935 2.33e-23 100.0 2AF6W@1|root,3155U@2|Bacteria,4PJE5@976|Bacteroidetes,1IBGX@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_729_1 883080.HMPREF9697_02143 1.42e-25 104.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3JQKZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_162706_1 1229760.K4I381_9CAUD 2.3e-22 101.0 4QAPV@10239|Viruses,4QV7H@35237|dsDNA viruses no RNA stage,4QQ0U@28883|Caudovirales,4QHZK@10662|Myoviridae 10662|Myoviridae S regulation of transcription, DNA-dependent - - - - - - - - - - - - - k59_351683_2 1442599.JAAN01000010_gene314 1.54e-13 73.6 2DMBA@1|root,32GFI@2|Bacteria,1RM38@1224|Proteobacteria,1SNFE@1236|Gammaproteobacteria,1X66M@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_243702_2 1443122.Z958_08590 1.25e-06 51.6 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24UEE@186801|Clostridia 186801|Clostridia K helix-turn-helix - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_243702_3 717785.HYPMC_1215 1.27e-12 65.1 COG4197@1|root,COG4197@2|Bacteria,1PMBB@1224|Proteobacteria,2UKRA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DNA-binding transcriptional regulator Cro - - - - - - - - - - - - YdaS_antitoxin k59_338186_3 742767.HMPREF9456_03404 3.72e-37 131.0 COG0270@1|root,COG0270@2|Bacteria,4P351@976|Bacteroidetes 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_297546_1 279383.Q5DN75_9CAUD 2.57e-11 63.5 4QE7X@10239|Viruses,4QVF0@35237|dsDNA viruses no RNA stage,4QPUM@28883|Caudovirales,4QMAZ@10699|Siphoviridae 10699|Siphoviridae S Cytidine and deoxycytidylate deaminase zinc-binding region - - - - - - - - - - - - - k59_351916_4 388051.AUFE01000035_gene4020 1.1e-44 160.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_41626_2 1038867.AXAY01000025_gene2041 6.51e-12 66.6 COG3096@1|root,COG3941@1|root,COG5280@1|root,COG3096@2|Bacteria,COG3941@2|Bacteria,COG5280@2|Bacteria 2|Bacteria NT Phage tail tape measure protein TP901 yqbO5 GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin,PhageMin_Tail,Phage_HK97_TLTM,TMP_2,Tape_meas_lam_C k59_29584_2 1618237.A0A0C5IMG6_9CIRC 5.88e-17 84.3 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_56723_1 1033806.HTIA_0896 1.16e-10 63.5 arCOG08099@1|root,arCOG08099@2157|Archaea,2XTZD@28890|Euryarchaeota,23S2K@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - k59_326819_1 1173028.ANKO01000246_gene4057 1.32e-127 380.0 COG1222@1|root,COG1222@2|Bacteria,1G1TR@1117|Cyanobacteria,1H87N@1150|Oscillatoriales 1117|Cyanobacteria O PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA k59_15874_2 1123487.KB892865_gene1410 3.52e-13 75.5 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,2VI3P@28216|Betaproteobacteria,2KUKX@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase dnaL - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_96837_1 1548905.A0A0A1IUN7_9CAUD 1.26e-10 67.8 4QF9I@10239|Viruses,4QTTB@28883|Caudovirales,4QN6Q@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_299089_1 89187.ISM_12830 3.56e-06 51.6 2DS89@1|root,33EYT@2|Bacteria,1NGG2@1224|Proteobacteria,2UKCA@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_177546_1 645099.MREP_BBTVA 8.5e-06 53.9 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_56734_1 1121286.AUMT01000013_gene2569 2.34e-12 70.9 2CC6P@1|root,302D1@2|Bacteria,4PJE7@976|Bacteroidetes,1IM38@117743|Flavobacteriia,3ZU1K@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_420202_2 1465639.A0A060BS16_9CAUD 6.66e-15 73.6 4QDJJ@10239|Viruses,4QYWQ@35237|dsDNA viruses no RNA stage,4QTQX@28883|Caudovirales,4QP11@10744|Podoviridae 10744|Podoviridae S magnesium ion binding - - - - - - - - - - - - - k59_70780_2 943335.F4N9U9_9CAUD 0.000693 48.1 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0044403,GO:0044406,GO:0044409,GO:0044411,GO:0044419,GO:0044423,GO:0044650,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027,GO:0098015,GO:0098024 - - - - - - - - - - - k59_2555_8 1282995.R9W0A5_9CAUD 8.61e-125 368.0 4QFB4@10239|Viruses,4QZ8P@35237|dsDNA viruses no RNA stage,4QSGK@28883|Caudovirales,4QKUP@10699|Siphoviridae 10699|Siphoviridae S viral capsid - - - - - - - - - - - - - k59_2555_10 246200.SPO1039 5.93e-49 181.0 28IAN@1|root,2Z8D8@2|Bacteria,1NJD6@1224|Proteobacteria,2VCTG@28211|Alphaproteobacteria,4NDNJ@97050|Ruegeria 28211|Alphaproteobacteria S Domain of unknown function (DUF4055) - - - - - - - - - - - - DUF4055 k59_2555_11 1005995.GTPT_1622 5.81e-79 254.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1RMTH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_96998_1 1329250.WOSG25_420010 2.89e-21 91.7 2CS3D@1|root,32SQ7@2|Bacteria,1V7ZJ@1239|Firmicutes,4IIIQ@91061|Bacilli,4AYBC@81850|Leuconostocaceae 91061|Bacilli S ERF superfamily - - - - - - - - - - - - ERF k59_16040_1 399795.CtesDRAFT_PD0612 1.02e-11 72.4 COG3209@1|root,COG3210@1|root,COG4675@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4675@2|Bacteria,1RJRG@1224|Proteobacteria,2WEZQ@28216|Betaproteobacteria 28216|Betaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - - k59_217774_1 1234888.K0A2J2_9VIRU 2.4e-80 257.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses 10239|Viruses S Capsid protein (F protein) - - - - - - - - - - - - - k59_164114_2 366394.Smed_1822 6.54e-14 74.7 2E4HT@1|root,32ZCW@2|Bacteria,1NC3H@1224|Proteobacteria,2UHMD@28211|Alphaproteobacteria,4BNMP@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_300582_2 1434319.W5RV68_9CAUD 1.15e-23 95.5 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QN92@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_408708_1 691965.D4P7I3_9CAUD 8.51e-71 240.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QKSZ@10699|Siphoviridae 10699|Siphoviridae S nucleic acid binding - - - - - - - - - - - - - k59_85645_1 864069.MicloDRAFT_00037670 4.86e-36 143.0 COG1061@1|root,COG1061@2|Bacteria,1N52C@1224|Proteobacteria,2U3TE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_408889_2 1692250.A0A0K1RLR1_9CIRC 9.48e-124 362.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_17465_1 1385658.U5KPZ6_9VIRU 1.93e-148 432.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_286854_4 1158294.JOMI01000007_gene779 1.73e-64 218.0 COG1783@1|root,COG1783@2|Bacteria,4NHPB@976|Bacteroidetes,2FR95@200643|Bacteroidia 976|Bacteroidetes S Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_232417_1 691965.D4P7D6_9CAUD 4.61e-57 202.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - - - - - - - - - - - - - k59_44282_3 105154.Q9MBU3_9VIRU 2.17e-05 52.0 4QCV4@10239|Viruses,4QUKY@29258|ssDNA viruses,4QP4B@10841|Microviridae 10841|Microviridae - - - - - - - - - - - - - - - k59_44282_4 1385658.U5KPZ6_9VIRU 7.08e-171 496.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_315973_1 1235559.K4HZF4_9CAUD 5.69e-28 123.0 4QAQ9@10239|Viruses,4QUYQ@35237|dsDNA viruses no RNA stage,4QPTV@28883|Caudovirales 28883|Caudovirales - - - GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044406,GO:0044419,GO:0044650,GO:0051704 - - - - - - - - - - - k59_368235_4 1051673.G0YQ57_9CAUD 4.59e-27 107.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNX8@10744|Podoviridae 10744|Podoviridae S N-acetylmuramoyl-L-alanine amidase activity - GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0008150,GO:0008745,GO:0016032,GO:0016787,GO:0016810,GO:0016811,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0032897,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0043900,GO:0043901,GO:0043903,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0046782,GO:0048519,GO:0048525,GO:0050789,GO:0050792,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783,GO:0065007 - - - - - - - - - - - k59_300835_1 1415780.JPOG01000001_gene1744 1.99e-22 105.0 COG0454@1|root,COG0827@1|root,COG1040@1|root,COG3087@1|root,COG0456@2|Bacteria,COG0827@2|Bacteria,COG1040@2|Bacteria,COG3087@2|Bacteria,1PI1K@1224|Proteobacteria,1T6BU@1236|Gammaproteobacteria,1XB7I@135614|Xanthomonadales 135614|Xanthomonadales D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_423143_1 1122137.AQXF01000001_gene2540 1.53e-22 100.0 COG3756@1|root,COG3756@2|Bacteria,1NGB2@1224|Proteobacteria,2VGAH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_167657_2 291985.CCSI01000003_gene297 2.66e-05 48.9 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2UDI9@28211|Alphaproteobacteria,2K5Q6@204457|Sphingomonadales 204457|Sphingomonadales S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_87894_1 512565.AMIS_71720 1.54e-13 75.1 COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4D8PQ@85008|Micromonosporales 201174|Actinobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_262667_1 742740.HMPREF9474_02272 1.69e-28 114.0 COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,222GA@1506553|Lachnoclostridium 186801|Clostridia S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_209894_1 1089548.KI783301_gene2629 6.55e-39 143.0 COG0863@1|root,COG0863@2|Bacteria,1UZIN@1239|Firmicutes,4HU16@91061|Bacilli 91061|Bacilli L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_288666_3 1327981.S0A2I3_9CAUD 1.79e-08 57.8 4QB1F@10239|Viruses,4QUYH@35237|dsDNA viruses no RNA stage,4QPSW@28883|Caudovirales,4QKPW@10699|Siphoviridae 10699|Siphoviridae S exonuclease activity - - - - - - - - - - - - - k59_75727_1 742740.HMPREF9474_02263 8.58e-33 118.0 2ARVA@1|root,31H70@2|Bacteria,1V7JT@1239|Firmicutes,24JPE@186801|Clostridia,222RD@1506553|Lachnoclostridium 186801|Clostridia S Bacteriophage HK97-gp10, putative tail-component - - - - - - - - - - - - HK97-gp10_like k59_75727_2 411460.RUMTOR_01335 6.93e-95 315.0 COG5412@1|root,COG5412@2|Bacteria,1UVV6@1239|Firmicutes,24F0S@186801|Clostridia 186801|Clostridia S phage tail tape measure protein - - - - - - - - - - - - - k59_302627_1 1214065.BAGV01000099_gene2075 7.77e-63 204.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_262986_1 104355.XP_007865213.1 2.13e-06 58.5 COG1793@1|root,KOG0966@2759|Eukaryota,38C9E@33154|Opisthokonta,3NUX9@4751|Fungi,3UZ1H@5204|Basidiomycota,228V1@155619|Agaricomycetes,3H31J@355688|Agaricomycetes incertae sedis 4751|Fungi L DNA ligase LIG4 GO:0000166,GO:0000228,GO:0000726,GO:0000785,GO:0000790,GO:0001302,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006289,GO:0006297,GO:0006302,GO:0006303,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007568,GO:0007569,GO:0008144,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016874,GO:0016886,GO:0017076,GO:0030447,GO:0030554,GO:0031974,GO:0031981,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032807,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0046483,GO:0048869,GO:0050896,GO:0051103,GO:0051704,GO:0051716,GO:0070013,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 6.5.1.1 ko:K10777 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - BRCT_2,DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,DNA_ligase_IV k59_143452_1 1121353.H924_07255 6.17e-22 98.6 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,22MAR@1653|Corynebacteriaceae 201174|Actinobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - SNF2_N k59_88153_1 102129.Lepto7375DRAFT_1731 2.59e-09 57.8 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_411237_1 1122201.AUAZ01000004_gene3425 6.61e-16 80.1 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,1RZZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU peptidase JD73_18850 - - ko:K21511 - - - - ko00000,ko01000 - - - Peptidase_S49 k59_251016_1 290317.Cpha266_0884 6.41e-07 50.4 COG1225@1|root,COG1225@2|Bacteria,1FDZX@1090|Chlorobi 1090|Chlorobi O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_251016_3 1239962.C943_03971 2.97e-23 97.1 COG1814@1|root,COG1814@2|Bacteria,4NE6W@976|Bacteroidetes,47M4I@768503|Cytophagia 976|Bacteroidetes S VIT family - - - - - - - - - - - - VIT1 k59_90633_1 1185652.USDA257_c54430 7.35e-05 45.8 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2TR2K@28211|Alphaproteobacteria,4BCNQ@82115|Rhizobiaceae 28211|Alphaproteobacteria C Oxidoreductase NAD-binding domain benC - 1.14.13.25 ko:K05784,ko:K16161 ko00362,ko00364,ko00622,ko00680,ko01100,ko01120,ko01200,ko01220,map00362,map00364,map00622,map00680,map01100,map01120,map01200,map01220 M00174,M00551 R01142,R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110 RC00173,RC00270,RC01378,RC01450,RC01910 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_291185_1 1168065.DOK_11926 1.72e-07 56.2 COG5377@1|root,COG5377@2|Bacteria,1QXFN@1224|Proteobacteria,1RR25@1236|Gammaproteobacteria 1236|Gammaproteobacteria L phage-type endonuclease - - - - - - - - - - - - YqaJ k59_413418_1 1618248.A0A0C5IB82_9CIRC 5.37e-63 206.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_384198_1 742727.HMPREF9447_04874 2.22e-55 181.0 COG0863@1|root,COG0863@2|Bacteria,4NQQ1@976|Bacteroidetes,2G1PS@200643|Bacteroidia,4ARBB@815|Bacteroidaceae 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_372010_6 928724.SacglDRAFT_00132 2.39e-38 154.0 COG0438@1|root,COG0438@2|Bacteria,2GUEW@201174|Actinobacteria,4DXDM@85010|Pseudonocardiales 201174|Actinobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_2,Glycos_transf_1,Methyltransf_21 k59_372010_10 1417599.U6C6Z0_9CAUD 2.11e-16 80.5 4QB55@10239|Viruses,4QW4S@35237|dsDNA viruses no RNA stage,4QSJ0@28883|Caudovirales,4QNGX@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_321780_1 691883.XP_009494328.1 1.86e-08 56.6 COG0086@1|root,KOG0260@2759|Eukaryota,38CEW@33154|Opisthokonta 33154|Opisthokonta K DNA-directed 5'-3' RNA polymerase activity POLR2A GO:0000228,GO:0000375,GO:0000377,GO:0000398,GO:0000428,GO:0000731,GO:0000785,GO:0000790,GO:0000791,GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003824,GO:0003899,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005694,GO:0005700,GO:0005703,GO:0005719,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006301,GO:0006351,GO:0006352,GO:0006353,GO:0006354,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007369,GO:0008150,GO:0008152,GO:0008380,GO:0008543,GO:0009058,GO:0009059,GO:0009299,GO:0009301,GO:0009452,GO:0009653,GO:0009719,GO:0009790,GO:0009792,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010470,GO:0010494,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016071,GO:0016073,GO:0016591,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019985,GO:0022603,GO:0023052,GO:0030880,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031625,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032774,GO:0032991,GO:0033120,GO:0033554,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035327,GO:0035770,GO:0036260,GO:0036464,GO:0040019,GO:0042221,GO:0042789,GO:0042795,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043484,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044344,GO:0044389,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0045893,GO:0045935,GO:0045995,GO:0046483,GO:0048518,GO:0048522,GO:0048598,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051171,GO:0051173,GO:0051239,GO:0051240,GO:0051252,GO:0051254,GO:0051716,GO:0055029,GO:0060147,GO:0060255,GO:0060964,GO:0060966,GO:0060968,GO:0061695,GO:0065007,GO:0070013,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0071897,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097747,GO:0098687,GO:0098781,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1902680,GO:1903506,GO:1903508,GO:1990234,GO:1990841,GO:1990904,GO:2000026,GO:2000112,GO:2000543,GO:2001141 2.7.7.6 ko:K03006 ko00230,ko00240,ko01100,ko03020,ko05016,ko05168,ko05169,map00230,map00240,map01100,map03020,map05016,map05168,map05169 M00180 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb1_6,RNA_pol_Rpb1_7,RNA_pol_Rpb1_R k59_22348_1 471854.Dfer_3901 1.9e-32 120.0 2DG4N@1|root,2ZUGX@2|Bacteria,4PAWS@976|Bacteroidetes,47UQD@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_251195_1 1028806.GGE_1154 8.23e-32 116.0 COG4570@1|root,COG4570@2|Bacteria,1N92D@1224|Proteobacteria,1SDZ5@1236|Gammaproteobacteria,1Y8UC@135625|Pasteurellales 135625|Pasteurellales L Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC - - 3.1.22.4 ko:K01160 - - - - ko00000,ko01000,ko03400 - - - RusA k59_212936_3 1121100.JCM6294_548 7.57e-21 90.1 2DN1F@1|root,32UYC@2|Bacteria,4NUCU@976|Bacteroidetes,2FRI0@200643|Bacteroidia,4AREB@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_347628_1 76114.ebA7273 1.39e-97 291.0 28J67@1|root,2Z91Y@2|Bacteria,1R7RG@1224|Proteobacteria,2VRTM@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_92662_1 1034101.G1D1G4_9CAUD 5.97e-51 173.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_24287_1 391038.Bphy_1861 3.27e-23 100.0 2CWXD@1|root,32T0J@2|Bacteria,1N3Z7@1224|Proteobacteria,2VUEJ@28216|Betaproteobacteria,1K8Z8@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_24287_2 34506.g5960 1.76e-21 95.9 COG3040@1|root,KOG4824@2759|Eukaryota,3AQKQ@33154|Opisthokonta,3C2XJ@33208|Metazoa,3DI0Q@33213|Bilateria 33208|Metazoa M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_223316_1 1589297.A0A0B5H2N7_9CAUD 1.05e-40 166.0 4QAXA@10239|Viruses,4QQ1A@28883|Caudovirales,4QNU7@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - k59_215614_4 1230342.CTM_17217 5.96e-36 130.0 28J2E@1|root,2Z8YX@2|Bacteria,1TRF9@1239|Firmicutes,249U3@186801|Clostridia,36EHP@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_215614_6 592031.GCWU000322_00065 5.12e-71 250.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,25VF0@186806|Eubacteriaceae 186801|Clostridia L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_215614_8 626887.J057_01800 3.63e-23 90.9 2DN5T@1|root,32VQG@2|Bacteria,1N6A1@1224|Proteobacteria,1SB7Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_215614_11 673839.D2J050_9CAUD 2.52e-91 290.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_400635_1 102129.Lepto7375DRAFT_7190 5.11e-56 186.0 COG0338@1|root,COG0338@2|Bacteria,1G0BF@1117|Cyanobacteria,1H9B8@1150|Oscillatoriales 1117|Cyanobacteria L PFAM D12 class N6 adenine-specific DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_400635_2 1121267.JHZL01000005_gene1685 4.22e-124 364.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42NPS@68525|delta/epsilon subdivisions,2YNCM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Cytosine-specific methyltransferase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_350019_2 926556.Echvi_1547 9.1e-21 83.2 2CB74@1|root,33E9Q@2|Bacteria,4NXAI@976|Bacteroidetes,47WE8@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_237410_2 194966.Q7Y5M4_BPSP6 1.02e-30 112.0 4QB6G@10239|Viruses,4QVYX@35237|dsDNA viruses no RNA stage,4QQS8@28883|Caudovirales,4QNR7@10744|Podoviridae 10744|Podoviridae S Peptidase M15 - - - - - - - - - - - - - k59_10118_1 1123057.P872_06065 2.07e-35 137.0 COG4227@1|root,COG4227@2|Bacteria,4NH93@976|Bacteroidetes,47XS9@768503|Cytophagia 976|Bacteroidetes L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738 k59_172150_1 1410616.JHXE01000018_gene2018 6.83e-10 68.9 COG1674@1|root,COG1674@2|Bacteria,1V7UZ@1239|Firmicutes,24PWS@186801|Clostridia 186801|Clostridia D FtsK SpoIIIE family protein - - - - - - - - - - - - FtsK_SpoIIIE k59_172150_7 1504822.CCNO01000015_gene594 6.15e-24 103.0 COG0553@1|root,COG0863@1|root,COG0553@2|Bacteria,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - - - - - - - - - - - Helicase_C,N6_N4_Mtase,SNF2_N k59_427345_3 1088721.NSU_0757 3.48e-34 125.0 2AJ1X@1|root,319K5@2|Bacteria,1RK0X@1224|Proteobacteria,2UKUD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2829) - - - - - - - - - - - - DUF2829 k59_185235_1 1304275.C41B8_05408 1.52e-102 309.0 2DVPY@1|root,33WQ8@2|Bacteria,1N9VQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_105116_1 595460.RRSWK_00105 4.16e-55 196.0 COG5511@1|root,COG5511@2|Bacteria,2IZFA@203682|Planctomycetes 203682|Planctomycetes S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_199210_1 1521187.JPIM01000119_gene2808 7.94e-05 43.1 COG2026@1|root,COG2026@2|Bacteria,2G9D2@200795|Chloroflexi,377W0@32061|Chloroflexia 32061|Chloroflexia DJ ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_253041_1 411901.BACCAC_01181 7.46e-10 66.2 COG0175@1|root,COG0175@2|Bacteria,4PJ0N@976|Bacteroidetes,2FQI4@200643|Bacteroidia,4APTN@815|Bacteroidaceae 976|Bacteroidetes EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_387431_1 198467.NP92_08535 1.63e-07 57.0 COG0664@1|root,COG0664@2|Bacteria,1TVBM@1239|Firmicutes,4HEJG@91061|Bacilli 91061|Bacilli K cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp2 - - ko:K10914,ko:K21562 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_387446_1 1040987.AZUY01000006_gene1805 1.48e-27 115.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,43K5X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_282437_3 1408445.JHXP01000010_gene2213 3.57e-07 61.2 COG5519@1|root,COG5519@2|Bacteria,1MW5H@1224|Proteobacteria,1RQ7H@1236|Gammaproteobacteria,1JE3F@118969|Legionellales 118969|Legionellales L Domain of unknown function (DUF927) - - - - - - - - - - - - DUF927 k59_255837_1 882.DVU_1494 1.06e-62 211.0 2F9PM@1|root,341ZU@2|Bacteria,1NXRW@1224|Proteobacteria,430XU@68525|delta/epsilon subdivisions,2WVTB@28221|Deltaproteobacteria,2MCVE@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_121084_1 1196323.ALKF01000200_gene2705 2.58e-77 242.0 COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,4H9QS@91061|Bacilli,26T1B@186822|Paenibacillaceae 91061|Bacilli F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_121084_3 1538804.A0A088F6T3_9CAUD 8.14e-06 47.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_430548_2 1475143.W8SNN0_9CIRC 6.29e-53 181.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_239880_1 1437608.BBIA_1428 3.73e-07 57.4 COG3941@1|root,COG5412@1|root,COG3941@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,4CZ35@85004|Bifidobacteriales 201174|Actinobacteria S phage tail tape measure protein - - - - - - - - - - - - - k59_392093_1 1556290.A0A0A0RM05_9CAUD 4.9e-139 418.0 4QAYV@10239|Viruses,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_68461_1 460265.Mnod_6264 1.12e-60 196.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,1JXA2@119045|Methylobacteriaceae 28211|Alphaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_311515_1 992406.RIA_0183 1.33e-10 59.7 COG1694@1|root,COG1694@2|Bacteria,4NXGF@976|Bacteroidetes,1IB36@117743|Flavobacteriia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_149300_2 490913.C4NTE2_9CAUD 8.09e-33 118.0 4QG5J@10239|Viruses,4QZ68@35237|dsDNA viruses no RNA stage,4QUEU@28883|Caudovirales,4QNKE@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_311528_1 1986029.Q9MBM8_9VIRU 1.02e-70 229.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_338264_1 398720.MED217_15260 9.2e-14 78.2 COG5295@1|root,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia 976|Bacteroidetes UW surface antigen - - - - - - - - - - - - Peptidase_S74 k59_284026_2 945713.IALB_0711 2.4e-16 80.1 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria 2|Bacteria L intein-mediated protein splicing dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing k59_81891_1 398578.Daci_1652 4.76e-18 79.7 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2VRGU@28216|Betaproteobacteria,4AHQM@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_81891_3 1230476.C207_01171 6.33e-35 125.0 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria,3K04T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_392114_1 1415148.V5Q7J2_9CAUD 6.05e-09 60.1 4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_285413_1 1133022.I6NLI9_9CAUD 2.13e-07 54.7 4QAK6@10239|Viruses,4QZ1J@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_299025_1 84739.I2BFP2_9VIRU 2.04e-70 243.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA polymerase family B - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004527,GO:0004540,GO:0005575,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0018995,GO:0019058,GO:0019079,GO:0019438,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0042025,GO:0042221,GO:0043170,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0050896,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902074 - - - - - - - - - - - k59_313579_1 1282362.AEAC466_13420 1.61e-55 194.0 COG3566@1|root,COG3566@2|Bacteria,1REIQ@1224|Proteobacteria,2U9XH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2213) - - - ko:K09960 - - - - ko00000 - - - DUF2213 k59_340167_1 1158338.JNLJ01000001_gene1208 1.36e-15 84.7 COG0749@1|root,COG0749@2|Bacteria,2G4NU@200783|Aquificae 200783|Aquificae L DNA polymerase polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A,DNA_pol_A_exo1 k59_15813_2 1519439.JPJG01000088_gene695 4.63e-52 170.0 2C5J1@1|root,3067M@2|Bacteria,1V52W@1239|Firmicutes,24J2G@186801|Clostridia,2N7M3@216572|Oscillospiraceae 186801|Clostridia S COG NOG12663 non supervised orthologous group - - - - - - - - - - - - - k59_205093_2 1692249.A0A0K1RL40_9CIRC 1.24e-25 109.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_353526_1 575540.Isop_2441 1.97e-18 81.3 2CEI6@1|root,2ZED5@2|Bacteria,2J3S1@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_56671_1 1465751.W8QF52_9VIRU 5.63e-56 194.0 4QH6D@10239|Viruses,4QVWD@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_407120_1 1129146.H2BDG1_9CAUD 1.72e-21 95.9 4QBF0@10239|Viruses,4QVD8@35237|dsDNA viruses no RNA stage,4QRRZ@28883|Caudovirales,4QMKU@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_340175_2 873449.STRCR_0884 8.19e-05 48.5 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_4,Glycos_transf_2 k59_366613_2 1555201.A0A097EWB2_9CAUD 5.47e-27 103.0 4QGDB@10239|Viruses,4QSG0@28883|Caudovirales,4QM88@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_123508_2 1380387.JADM01000008_gene930 9.59e-30 135.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,1RP2D@1236|Gammaproteobacteria,1XKUI@135619|Oceanospirillales 135619|Oceanospirillales S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_326756_1 1385658.U5KPZ6_9VIRU 1.88e-39 149.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_313796_1 525909.Afer_1986 8.17e-10 67.8 COG2385@1|root,COG4733@1|root,COG2385@2|Bacteria,COG4733@2|Bacteria,2HGMX@201174|Actinobacteria,4CNMU@84992|Acidimicrobiia 84992|Acidimicrobiia D Peptidase A4 family - - - - - - - - - - - - Peptidase_A4 k59_217751_2 1379717.S5SY19_9CIRC 7.43e-71 228.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_379978_1 1343494.S0F3I3_9VIRU 0.000895 47.0 4QBCQ@10239|Viruses,4QUMB@29258|ssDNA viruses,4QP4S@10860|Inoviridae 10860|Inoviridae S DNA topoisomerase activity - - - - - - - - - - - - - k59_393523_2 466051.A7XXB7_9CAUD 9.42e-07 55.8 4QH61@10239|Viruses,4QVEZ@35237|dsDNA viruses no RNA stage,4QUBW@28883|Caudovirales,4QKQU@10699|Siphoviridae 10699|Siphoviridae S Terminase-like family - - - - - - - - - - - - - k59_42979_1 318996.AXAZ01000113_gene349 6.38e-63 234.0 COG1749@1|root,COG4932@1|root,COG1749@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Cadherin,Cadherin_3,Calx-beta,FecR,PKD,SdrD_B,TGFb_propeptide k59_231190_3 1454202.PPBDW_80232___1 4.42e-09 63.2 COG3306@1|root,COG3306@2|Bacteria,1R7HN@1224|Proteobacteria,1SAQK@1236|Gammaproteobacteria,1XX32@135623|Vibrionales 135623|Vibrionales M Glycosyltransferase family 25 (LPS biosynthesis protein) - - - ko:K07270 - - - - ko00000 - GT25 - Glyco_transf_25 k59_231190_4 72019.SARC_03505T0 3.05e-24 104.0 2CY1A@1|root,2S19M@2759|Eukaryota,3A5D1@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - - k59_231190_20 1357714.A0A067XQU5_9CAUD 3.62e-20 86.7 4QE3P@10239|Viruses,4QX79@35237|dsDNA viruses no RNA stage,4QSZ8@28883|Caudovirales,4QK0B@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_246976_1 1327990.S0A3B9_9CAUD 3.19e-18 81.3 4QC5A@10239|Viruses,4QX98@35237|dsDNA viruses no RNA stage,4QRV3@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_246976_2 984262.SGRA_2177 4.61e-31 115.0 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1ISJD@117747|Sphingobacteriia 976|Bacteroidetes L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_260555_1 1114922.CIFAM_19_00100 2.72e-16 84.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,1S17I@1236|Gammaproteobacteria,3WX6G@544|Citrobacter 1236|Gammaproteobacteria L DNA methylase yhdJ GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032775,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_260555_2 29540.C481_08216 0.000119 43.5 COG1573@1|root,arCOG00905@2157|Archaea,2XUC0@28890|Euryarchaeota,23TCN@183963|Halobacteria 183963|Halobacteria L Phage SPO1 DNA - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_260753_1 156889.Mmc1_1012 2.25e-35 137.0 COG2268@1|root,COG2268@2|Bacteria,1NT13@1224|Proteobacteria,2U335@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Band 7 protein - - - - - - - - - - - - - k59_152639_1 1123276.KB893279_gene2206 1.78e-23 103.0 COG1061@1|root,COG1061@2|Bacteria,4NECV@976|Bacteroidetes,47NKQ@768503|Cytophagia 976|Bacteroidetes L Type III restriction enzyme, res subunit res - - - - - - - - - - - Helicase_C,ResIII k59_247191_1 1410620.SHLA_4c001010 3.03e-05 47.4 2CEI6@1|root,2ZED5@2|Bacteria,1RCK0@1224|Proteobacteria,2U5ND@28211|Alphaproteobacteria,4BHCH@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_247191_2 571166.KI421509_gene1198 1.49e-71 226.0 28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,2TSHZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - PDDEXK_1 k59_409097_5 561175.KB894093_gene2988 1.99e-11 74.7 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ER4V@85012|Streptosporangiales 201174|Actinobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - DUF5122,Malectin,PKD k59_152643_1 765912.Thimo_1781 2.9e-41 143.0 COG1475@1|root,COG1475@2|Bacteria,1NAV4@1224|Proteobacteria,1SF4D@1236|Gammaproteobacteria 1236|Gammaproteobacteria K DNA binding - - - - - - - - - - - - - k59_342737_1 1121289.JHVL01000007_gene2770 1.77e-38 142.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae 186801|Clostridia L snf2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_342737_2 351746.Pput_4150 2.36e-50 173.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,1RY8S@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_1,Phage_int_SAM_4,Phage_integrase k59_328806_1 1692255.A0A0K1RL52_9CIRC 1.29e-171 485.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_288955_2 575540.Isop_2441 1.51e-41 142.0 2CEI6@1|root,2ZED5@2|Bacteria,2J3S1@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF669) - - - - - - - - - - - - DUF669 k59_288955_6 553217.ENHAE0001_2189 6.79e-53 176.0 COG1100@1|root,COG1100@2|Bacteria 2|Bacteria S GTP binding - - - - - - - - - - - - MMR_HSR1,Zeta_toxin k59_275115_1 77048.O80199_9CAUD 2.02e-23 102.0 4QH67@10239|Viruses,4QXEE@35237|dsDNA viruses no RNA stage,4QTBT@28883|Caudovirales,4QMA5@10699|Siphoviridae 10699|Siphoviridae S Terminase-like family - - - - - - - - - - - - - k59_88274_2 1123020.AUIE01000007_gene3229 1.31e-10 62.0 2CJWY@1|root,31CWF@2|Bacteria,1RKEF@1224|Proteobacteria,1S75P@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_358778_1 259536.Psyc_1765 1.76e-08 65.9 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,3NJXX@468|Moraxellaceae 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) slt GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 iETEC_1333.ETEC_4747,iPC815.YPO0452 SLT,SLT_L k59_396872_3 1347393.HG726021_gene517 3.65e-17 80.1 2BR89@1|root,32K6M@2|Bacteria,4NQWW@976|Bacteroidetes,2FT14@200643|Bacteroidia,4ASE9@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_154819_2 298386.PBPRB1277 2.03e-05 49.7 COG5281@1|root,COG5281@2|Bacteria,1QUCD@1224|Proteobacteria,1T1T2@1236|Gammaproteobacteria 1236|Gammaproteobacteria D tape measure protein - - - - - - - - - - - - Phage_HK97_TLTM,TMP_2,Tape_meas_lam_C k59_303050_1 179237.Q8W6L0_9CAUD 2.81e-35 144.0 4QHMY@10239|Viruses,4QW88@35237|dsDNA viruses no RNA stage,4QSGS@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_194696_2 1476876.JOJO01000002_gene6625 8.85e-95 290.0 COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria 2|Bacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_33953_1 222534.KB893683_gene1108 4.43e-05 52.4 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_289145_6 1120978.KB894081_gene102 1.15e-23 109.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1TPHP@1239|Firmicutes,4HC9M@91061|Bacilli 91061|Bacilli KL Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_143966_1 384676.PSEEN2521 6.51e-48 171.0 COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaC - 1.7.1.7 ko:K00364 ko00230,map00230 - R01134 RC00457 ko00000,ko00001,ko01000 - - - IMPDH k59_101347_1 1556290.A0A0A0RQI3_9CAUD 4.68e-120 379.0 4QCZC@10239|Viruses,4QRH3@28883|Caudovirales,4QM07@10699|Siphoviridae 10699|Siphoviridae S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_76659_2 1475143.W8SNN0_9CIRC 1.87e-18 87.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_113891_4 1327982.S0A2R8_9CAUD 2.52e-52 176.0 4QE8H@10239|Viruses,4R0CV@35237|dsDNA viruses no RNA stage,4QQA3@28883|Caudovirales 28883|Caudovirales S transferase activity - - - - - - - - - - - - - k59_76671_2 1280944.HY17_04460 7.66e-19 91.3 COG3723@1|root,COG3723@2|Bacteria,1QZ88@1224|Proteobacteria 1224|Proteobacteria L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_181883_1 926567.TheveDRAFT_1223 1.37e-09 57.4 COG2359@1|root,COG2359@2|Bacteria,3TBE1@508458|Synergistetes 508458|Synergistetes S PFAM Stage V sporulation protein S - - - ko:K06416 - - - - ko00000 - - - SpoVS k59_291231_4 1347368.HG964405_gene6101 1.59e-71 244.0 COG3391@1|root,COG4632@1|root,COG4733@1|root,COG3391@2|Bacteria,COG4632@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity tagL - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Flg_new,NAGPA,SLH k59_147008_1 445973.CLOBAR_01543 3.51e-18 89.4 COG3864@1|root,COG3864@2|Bacteria,1VBUS@1239|Firmicutes,24T0H@186801|Clostridia 186801|Clostridia S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_196665_1 314265.R2601_24025 1.26e-29 125.0 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_399012_1 1123237.Salmuc_03630 2.13e-83 259.0 COG1403@1|root,COG1403@2|Bacteria,1QE4E@1224|Proteobacteria 1224|Proteobacteria L HNH endonuclease - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_251311_1 1166018.FAES_3935 0.000311 44.7 COG1783@1|root,COG5410@1|root,COG1783@2|Bacteria,COG5410@2|Bacteria,4NN30@976|Bacteroidetes,47YRR@768503|Cytophagia 976|Bacteroidetes S Phage terminase large subunit - - - - - - - - - - - - Terminase_6 k59_361718_2 1337093.MBE-LCI_1558 2.94e-11 64.3 2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_321918_1 1192759.AKIB01000023_gene2894 1.79e-11 69.7 2EXSU@1|root,33R23@2|Bacteria,1NS77@1224|Proteobacteria,2UR4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_251328_1 490913.C4NTF6_9CAUD 2.57e-97 298.0 4QEFX@10239|Viruses,4QYYG@35237|dsDNA viruses no RNA stage,4QRRV@28883|Caudovirales,4QNTK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_157489_2 520999.PROVALCAL_00650 6.17e-34 121.0 COG1694@1|root,COG1694@2|Bacteria,1N3XF@1224|Proteobacteria,1SSUP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - - k59_157489_4 998086.F8SJ76_9CAUD 8.5e-36 144.0 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales 28883|Caudovirales S N-acetyltransferase activity - - - - - - - - - - - - - k59_129252_2 1385658.U5KNR1_9VIRU 1.02e-75 241.0 4QFB7@10239|Viruses,4QUN2@29258|ssDNA viruses,4QP4A@10841|Microviridae 10841|Microviridae L ATP binding - - - - - - - - - - - - - k59_129252_4 1986029.Q9MBM8_9VIRU 1.82e-231 655.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_347734_1 1122931.AUAE01000034_gene2775 4.68e-06 59.3 COG1196@1|root,COG1196@2|Bacteria,4NF3E@976|Bacteroidetes,2FNYJ@200643|Bacteroidia,22YP9@171551|Porphyromonadaceae 976|Bacteroidetes D Psort location OuterMembrane, score - - - - - - - - - - - - - k59_172168_2 990285.RGCCGE502_22705 2.57e-27 119.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,2U1H4@28211|Alphaproteobacteria,4BCD7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage-related minor tail protein - - - - - - - - - - - - Peptidase_M15_3,PhageMin_Tail k59_10144_1 1000565.METUNv1_01735 2.22e-16 85.1 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,2VRP1@28216|Betaproteobacteria,2KXNP@206389|Rhodocyclales 206389|Rhodocyclales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_199226_1 10719.THYX_BPPHC 8.5e-43 150.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales,4QKRA@10699|Siphoviridae 10699|Siphoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_253055_1 1121451.DESAM_22831 2.82e-05 52.0 2DNU8@1|root,32Z5M@2|Bacteria,1NARQ@1224|Proteobacteria,432SD@68525|delta/epsilon subdivisions,2WY7K@28221|Deltaproteobacteria,2MD12@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_223354_3 289376.THEYE_A0307 7.81e-13 64.7 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - - - - - - - - - - ParBc k59_307681_1 1220717.L7TP31_9VIRU 1.55e-25 108.0 4QC2G@10239|Viruses 10239|Viruses S Ribonucleotide reductase, small chain - - - - - - - - - - - - - k59_253060_1 1195073.I6XKW3_9CAUD 3.24e-15 77.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_267645_2 478749.BRYFOR_07474 1.33e-05 53.1 COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_172192_1 1379713.S5SYD9_9CIRC 4.91e-19 89.4 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_199261_1 411460.RUMTOR_01342 3.6e-54 178.0 28NM4@1|root,2ZBMQ@2|Bacteria,1V1QD@1239|Firmicutes,24G1B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_350111_1 1215092.PA6_009_00330 1.54e-12 72.8 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_350111_2 1444309.JAQG01000013_gene1951 3.05e-32 129.0 COG0507@1|root,COG0507@2|Bacteria,1TQWH@1239|Firmicutes,4HF2Y@91061|Bacilli,26WBJ@186822|Paenibacillaceae 91061|Bacilli L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,Terminase_3 k59_172415_1 1343739.PAP_06450 1.05e-27 105.0 COG0588@1|root,arCOG01993@2157|Archaea 2157|Archaea G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate - - - - - - - - - - - - His_Phos_1 k59_279404_3 1379712.S5TMV9_9CIRC 1.01e-18 89.7 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_333313_3 648885.KB316282_gene1384 6.32e-82 270.0 2CC8M@1|root,308VJ@2|Bacteria,1R789@1224|Proteobacteria,2U2NB@28211|Alphaproteobacteria,1JW8K@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_172419_1 997346.HMPREF9374_1135 2.69e-20 89.4 2E2AR@1|root,30K7X@2|Bacteria,1U53G@1239|Firmicutes,4I91A@91061|Bacilli,27D91@186824|Thermoactinomycetaceae 91061|Bacilli S HNH endonuclease - - - - - - - - - - - - HNH_3 k59_51292_1 329254.Q2NPH5_9CAUD 1.06e-94 301.0 4QEIG@10239|Viruses,4R0E7@35237|dsDNA viruses no RNA stage,4QTGA@28883|Caudovirales 28883|Caudovirales S regulation of transcription, DNA-dependent - - - - - - - - - - - - - k59_415609_1 888059.HMPREF9071_2133 1.76e-12 69.7 COG1783@1|root,COG1783@2|Bacteria,4NHPB@976|Bacteroidetes,1IH79@117743|Flavobacteriia,1ESIH@1016|Capnocytophaga 976|Bacteroidetes S Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_107223_1 105154.Q9MBU6_9VIRU 4.49e-73 236.0 4QFNI@10239|Viruses,4QUMX@29258|ssDNA viruses,4QP49@10841|Microviridae 10841|Microviridae S structural molecule activity - - - - - - - - - - - - - k59_26609_6 856793.MICA_588 1.1e-16 88.2 COG0468@1|root,COG0468@2|Bacteria,1PK58@1224|Proteobacteria,2UB77@28211|Alphaproteobacteria 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_24 k59_417669_4 1306947.ARQD01000003_gene224 2.83e-28 110.0 COG1351@1|root,COG1351@2|Bacteria,2NPQ2@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - HNH,Thy1 k59_387219_1 1618248.A0A0C5IB82_9CIRC 8.74e-15 73.2 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_387219_2 1788454.A0A190WHE4_9CIRC 3.07e-31 119.0 4QB1C@10239|Viruses,4QUKV@29258|ssDNA viruses 10239|Viruses S ATPase activity, uncoupled - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039682,GO:0039684,GO:0039687,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_255489_8 1126950.G9J1V7_9CAUD 6.39e-14 68.9 4QBE2@10239|Viruses,4R0FU@35237|dsDNA viruses no RNA stage,4QT8G@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_403066_1 1986029.Q9MBM6_9VIRU 2.06e-21 90.9 4QDBB@10239|Viruses,4QUM0@29258|ssDNA viruses,4QP4D@10841|Microviridae 10841|Microviridae S Chlamydia-phage Chp2 scaffold (Chlamy_scaf) - - - - - - - - - - - - - k59_187954_1 596152.DesU5LDRAFT_1450 3.83e-35 138.0 COG3170@1|root,COG3170@2|Bacteria,1N4R0@1224|Proteobacteria,42QKG@68525|delta/epsilon subdivisions,2WMF1@28221|Deltaproteobacteria,2MBE5@213115|Desulfovibrionales 28221|Deltaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_282251_2 445970.ALIPUT_02667 6.03e-79 248.0 2BKC5@1|root,32ESM@2|Bacteria,4PAIX@976|Bacteroidetes,2FX36@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_282251_3 445970.ALIPUT_02668 7.71e-25 102.0 COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FRXC@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4417,ParBc k59_120144_1 1038866.KB902768_gene5313 2.79e-06 54.3 COG0673@1|root,COG0673@2|Bacteria,1QW91@1224|Proteobacteria,2TU6E@28211|Alphaproteobacteria,3JVT4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_107674_1 1476391.X5KNB4_9CAUD 6.55e-22 101.0 4QAXA@10239|Viruses,4QYJI@35237|dsDNA viruses no RNA stage,4QQ1A@28883|Caudovirales,4QNU7@10744|Podoviridae 10744|Podoviridae S metallopeptidase activity - - - - - - - - - - - - - ## 5899 queries scanned ## Total time (seconds): 88.24255728721619 ## Rate: 66.85 q/s